Cheap flights from Orlando Airport to Knoxville from $39

The month of August is, on average, the cheapest month to fly to Knoxville from Orlando Airport, with most prices found around $109. If you aren’t able to travel during the month of August, then book flights to Knoxville from Orlando Airport during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $119.

The cheapest day to depart from Orlando Airport to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $139. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Orlando Airport to Knoxville for around $184.

In the evening is the cheapest time of day to fly from Orlando Airport to Knoxville when you can find flight prices for as low as $140. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $168.

Fly from Orlando to Knoxville McGhee Tyson for the best Orlando - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Orlando Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $194 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Orlando Airport for as low as $116 on momondo.

There is only 1 cabin class available to choose from on Orlando to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest and Delta are the most popular carriers operating from Orlando to Knoxville McGhee Tyson

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to Knoxville from Orlando Airport according to our data. Allegiant Air is the first choice among our users, with 57% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 6 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

As of April 2026, 1 flights take off from Orlando Airport and land in Knoxville each day. The most common flight departure time for this route is 4:00PM, with 100% of daily flights taking off in the afternoon.

The number of flights available between Orlando Airport and Knoxville is 7 per week as of April 2026. The most frequent departure day is Mon, with 29% of weekly flights leaving on this day.