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Cheap flights from Chicago O'Hare Intl Airport to Florence from $208

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Florence departing on 9/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago O'Hare Intl Airport to Florence

Cheap round-trip flights

American Airlines Logo
5:00 am - 10:45 amORD-FLO
4h 45m1 stop
American Airlines Logo
10:28 am - 4:02 pmFLO-ORD
6h 34m1 stop
$393American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 8
American Airlines Logo
5:00 am - 10:45 amORD-FLO
4h 45m1 stop
American Airlines Logo
10:28 am - 4:51 pmFLO-ORD
7h 23m2 stops
$398American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 8
American Airlines Logo
5:00 am - 12:02 pmORD-FLO
6h 02m1 stop
American Airlines Logo
5:14 am - 9:25 amFLO-ORD
5h 11m1 stop
$415American Airlines
Find Deal
Mon, Sep 22 - Sun, Sep 28
American Airlines Logo
3:33 pm - 11:16 pmORD-FLO
6h 43m2 stops
American Airlines Logo
4:57 pm - 9:21 pmFLO-ORD
5h 24m1 stop
$420American Airlines
Find Deal
Mon, Sep 22 - Sun, Sep 28
American Airlines Logo
3:33 pm - 11:16 pmORD-FLO
6h 43m2 stops
American Airlines Logo
5:14 am - 11:06 amFLO-ORD
6h 52m2 stops
$425American Airlines
Find Deal
Mon, Sep 22 - Sun, Sep 28
American Airlines Logo
5:00 am - 12:02 pmORD-FLO
6h 02m1 stop
American Airlines Logo
5:14 am - 9:25 amFLO-ORD
5h 11m1 stop
$426American Airlines
Find Deal
Mon, Sep 22 - Sun, Sep 28
American Airlines Logo
3:33 pm - 11:16 pmORD-FLO
6h 43m2 stops
American Airlines Logo
5:14 am - 10:47 amFLO-ORD
6h 33m1 stop
$431American Airlines
Find Deal
Mon, Sep 22 - Sun, Sep 28
American Airlines Logo
5:08 pm - 11:16 pmORD-FLO
5h 08m1 stop
American Airlines Logo
5:37 pm - 11:12 pmFLO-ORD
6h 35m1 stop
$440American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
American Airlines Logo
5:08 pm - 11:16 pmORD-FLO
5h 08m1 stop
American Airlines Logo
6:14 am - 1:42 pmFLO-ORD
8h 28m2 stops
$445American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16
American Airlines Logo
3:33 pm - 11:16 pmORD-FLO
6h 43m2 stops
American Airlines Logo
6:14 am - 11:06 amFLO-ORD
5h 52m2 stops
$450American Airlines
Find Deal
Sat, Sep 13 - Tue, Sep 16

American Airlines flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Our best American Airlines deals on Chicago O'Hare Intl Airport to Florence, South Carolina flight tickets
American Airlines
Nov 27
ORD5:00 amChicago O'Hare Intl
4h 45m
1 stop
FLO10:45 amFlorence
Dec 8
FLO10:28 amFlorence
6h 34m
1 stop
ORD4:02 pmChicago O'Hare Intl
$393
Find similar
American Airlines
Nov 27
ORD5:00 amChicago O'Hare Intl
4h 45m
1 stop
FLO10:45 amFlorence
Dec 8
FLO10:28 amFlorence
7h 23m
2 stops
ORD4:51 pmChicago O'Hare Intl
$398
Find similar
American Airlines
Sep 22
ORD5:00 amChicago O'Hare Intl
6h 02m
1 stop
FLO12:02 pmFlorence
Sep 28
FLO5:14 amFlorence
5h 11m
1 stop
ORD9:25 amChicago O'Hare Intl
$415
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 2, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

10:28 am-4:02 pm

1 stop6h 34m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

10:28 am-4:51 pm

2 stops7h 23m

$398

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 9/22

5:00 am-12:02 pm

1 stop6h 02m

Florence

Sun 9/28

5:14 am-9:25 am

1 stop5h 11m

$415

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 9/22

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sun 9/28

4:57 pm-9:21 pm

1 stop5h 24m

$420

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 9/22

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sun 9/28

5:14 am-11:06 am

2 stops6h 52m

$425

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 9/22

5:00 am-12:02 pm

1 stop6h 02m

Florence

Sun 9/28

5:14 am-9:25 am

1 stop5h 11m

$426

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 9/22

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sun 9/28

5:14 am-10:47 am

1 stop6h 33m

$431

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 9/13

5:08 pm-11:16 pm

1 stop5h 08m

Florence

Tue 9/16

5:37 pm-11:12 pm

1 stop6h 35m

$440

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 9/13

5:08 pm-11:16 pm

1 stop5h 08m

Florence

Tue 9/16

6:14 am-1:42 pm

2 stops8h 28m

$445

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 9/13

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Tue 9/16

6:14 am-11:06 am

2 stops5h 52m

$450

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Chicago O'Hare Intl Airport is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $437. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Monday is the most expensive day to depart from Chicago O'Hare Intl Airport because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $449.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the afternoon. momondo users have found flights departing from Chicago O'Hare Intl Airport to Florence, South Carolina in the afternoon for as low as $437. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $477 per ticket.

When to book flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Florence, South Carolina (ORD to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Florence, South Carolina

Direct flights

None
There are no direct flights from Chicago O'Hare Intl Airport to Florence, South Carolina. There are no popular flight routes from Chicago O'Hare Intl Airport to Florence, South Carolina.
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  • How far is Chicago O'Hare Intl to Florence by plane?

    Chicago O'Hare Intl and Florence are 695.4 mi apart from one another. A reasonable flight in good conditions will take 4h 45m.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Florence Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Florence Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Chicago O'Hare Intl Airport to Florence, South Carolina?

Best airlines flying from Chicago O'Hare Intl Airport to Florence, South Carolina

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $290Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Chicago.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo helps you find the best flight between Chicago and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Chicago to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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