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Cheap flights from Chicago O'Hare Intl Airport to Florence from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Florence departing on 10/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Chicago O'Hare Intl Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:05 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 04m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 11:00 amFLO  Florence-ORD Chicago O'Hare Intl
5h 36m1 stop Charlotte Douglas
$355American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
6:49 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
6h 23m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$355American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:49 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
6h 23m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$435American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
1:22 pm - 9:20 pmORD  Chicago O'Hare Intl-FLO Florence
6h 58m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 7:38 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 55m1 stop Charlotte Douglas
$498American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
10:44 pm - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
14h 28m2 stops Lambert-St Louis Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$513American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
4:45 pm - 10:43 pmORD  Chicago O'Hare Intl-FLO Florence
4h 58m1 stop Charlotte Douglas
American Airlines Logo
6:20 pm - 12:02 amFLO  Florence-ORD Chicago O'Hare Intl
6h 42m1 stop Charlotte Douglas
$550American Airlines
Sun, Jan 17 - Sat, Mar 27
American Airlines Logo
6:49 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
6h 23m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 12:16 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 52m2 stops Charlotte Douglas Philadelphia
$584American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
7:50 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 19m2 stops Washington, D.C. Reagan-National Charlotte Douglas
American Airlines Logo
3:44 pm - 7:35 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 51m1 stop Charlotte Douglas
$584American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
6:29 am - 1:18 pmORD  Chicago O'Hare Intl-FLO Florence
5h 49m1 stop Charlotte Douglas
American Airlines Logo
2:34 pm - 7:51 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 17m1 stop Charlotte Douglas
$612American Airlines
Fri, Oct 2 - Mon, Oct 5
American Airlines Logo
6:00 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
7h 12m2 stops New York LaGuardia Charlotte Douglas
American Airlines Logo
6:24 am - 12:14 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 50m1 stop Charlotte Douglas
$656American Airlines
Sat, Sep 5 - Fri, Sep 11

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American Airlines flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Our best American Airlines deals on Chicago O'Hare Intl Airport to Florence, South Carolina flight tickets
American Airlines
Sep 5
ORD6:49 amChicago O'Hare Intl
6h 23m
1 stop
FLO2:12 pmFlorence
Sep 12
FLO1:43 pmFlorence
4h 55m
1 stop
ORD5:38 pmChicago O'Hare Intl
$355
American Airlines
Sep 5
ORD6:49 amChicago O'Hare Intl
6h 23m
1 stop
FLO2:12 pmFlorence
Sep 12
FLO1:43 pmFlorence
4h 55m
1 stop
ORD5:38 pmChicago O'Hare Intl
$435
American Airlines
Sep 5
ORD1:22 pmChicago O'Hare Intl
6h 58m
1 stop
FLO9:20 pmFlorence
Sep 11
FLO1:43 pmFlorence
6h 55m
1 stop
ORD7:38 pmChicago O'Hare Intl
$498

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

8:05 am-3:09 pm

1 stop6h 04m

Florence

Tue 11/10

6:24 am-11:00 am

1 stop5h 36m

$355

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:49 am-2:12 pm

1 stop6h 23m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$355

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:49 am-2:12 pm

1 stop6h 23m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$435

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

1:22 pm-9:20 pm

1 stop6h 58m

Florence

Fri 9/11

1:43 pm-7:38 pm

1 stop6h 55m

$498

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

10:44 pm-2:12 pm

2 stops14h 28m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$513

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sun 1/17

4:45 pm-10:43 pm

1 stop4h 58m

Florence

Sat 3/27

6:20 pm-12:02 am

1 stop6h 42m

$550

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:49 am-2:12 pm

1 stop6h 23m

Florence

Sat 9/12

6:24 am-12:16 pm

2 stops6h 52m

$584
Quickest round-trip

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

7:50 am-3:09 pm

2 stops6h 19m

Florence

Tue 11/10

3:44 pm-7:35 pm

1 stop4h 51m

$584

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Fri 10/2

6:29 am-1:18 pm

1 stop5h 49m

Florence

Mon 10/5

2:34 pm-7:51 pm

1 stop6h 17m

$612

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:00 am-2:12 pm

2 stops7h 12m

Florence

Fri 9/11

6:24 am-12:14 pm

1 stop6h 50m

$656

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago O'Hare Intl to Florence?

American Airlines is the most popular carrier operating from Chicago O'Hare Intl to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago O'Hare Intl Airport according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Florence, South Carolina (ORD to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Florence, South Carolina

Fastest flight time

6h 04m

Direct flights

None
The fastest flight from Chicago O'Hare Intl Airport to Florence, South Carolina takes 6h 04m
There are no direct flights from Chicago O'Hare Intl Airport to Florence, South Carolina. There are no popular flight routes from Chicago O'Hare Intl Airport to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to Florence, South Carolina

  • How far is Chicago O'Hare Intl to Florence by plane?

    Chicago O'Hare Intl and Florence are 695.4 mi apart from one another. A reasonable flight in good conditions will take 6h 04m.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Florence Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Chicago.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo helps you find the best flight between Chicago and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Chicago to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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