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Cheap flights from Chicago O'Hare Intl Airport to Florence from $198

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Florence departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago O'Hare Intl Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 pm - 11:57 pm
ORD
-
FLO
5h 57m
1 stop
American Airlines Logo
6:20 pm - 12:06 am
FLO
-
ORD
6h 46m
1 stop
$457American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
5:00 pm - 11:57 pm
ORD
-
FLO
5h 57m
1 stop
American Airlines Logo
5:16 am - 1:19 pm
FLO
-
ORD
9h 03m
2 stops
$462American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
3:16 pm - 11:08 pm
ORD
-
FLO
6h 52m
1 stop
American Airlines Logo
5:58 pm - 12:06 am
FLO
-
ORD
7h 08m
1 stop
$480American Airlines
ke, helmi 25 - ke, maalis 4
American Airlines Logo
9:40 am - 5:21 pm
ORD
-
FLO
6h 41m
2 stops
American Airlines Logo
6:15 am - 12:35 pm
FLO
-
ORD
7h 20m
1 stop
$485American Airlines
ke, helmi 25 - ke, maalis 4
American Airlines Logo
9:40 am - 5:21 pm
ORD
-
FLO
6h 41m
2 stops
American Airlines Logo
6:15 am - 1:19 pm
FLO
-
ORD
8h 04m
2 stops
$491American Airlines
ke, helmi 25 - ke, maalis 4
American Airlines Logo
6:22 pm - 11:57 pm
ORD
-
FLO
4h 35m
1 stop
American Airlines Logo
6:20 pm - 12:06 am
FLO
-
ORD
6h 46m
1 stop
$558American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
10:28 am - 5:50 pm
ORD
-
FLO
6h 22m
1 stop
American Airlines Logo
5:16 am - 12:05 pm
FLO
-
ORD
7h 49m
2 stops
$563American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
9:40 am - 5:50 pm
ORD
-
FLO
7h 10m
2 stops
American Airlines Logo
5:16 am - 12:05 pm
FLO
-
ORD
7h 49m
2 stops
$637American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
9:40 am - 5:50 pm
ORD
-
FLO
7h 10m
2 stops
American Airlines Logo
5:16 am - 12:05 pm
FLO
-
ORD
7h 49m
2 stops
$703American Airlines
to, helmi 26 - ma, maalis 2
American Airlines Logo
4:04 pm - 11:57 pm
ORD
-
FLO
6h 53m
2 stops
American Airlines Logo
5:16 am - 1:19 pm
FLO
-
ORD
9h 03m
2 stops
$844American Airlines
su, maalis 1 - to, maalis 5

American Airlines flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Our best American Airlines deals on Chicago O'Hare Intl Airport to Florence, South Carolina flight tickets
American Airlines
Feb 26
ORD5:00 pmChicago O'Hare Intl
5h 57m
1 stop
FLO11:57 pmFlorence
Mar 2
FLO6:20 pmFlorence
6h 46m
1 stop
ORD12:06 amChicago O'Hare Intl
$457
American Airlines
Feb 26
ORD5:00 pmChicago O'Hare Intl
5h 57m
1 stop
FLO11:57 pmFlorence
Mar 2
FLO5:16 amFlorence
9h 03m
2 stops
ORD1:19 pmChicago O'Hare Intl
$462
American Airlines
Feb 25
ORD3:16 pmChicago O'Hare Intl
6h 52m
1 stop
FLO11:08 pmFlorence
Mar 4
FLO5:58 pmFlorence
7h 08m
1 stop
ORD12:06 amChicago O'Hare Intl
$480

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated helmikuu 14, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

5:00 pm-11:57 pm

1 stop5h 57m

Florence

ma 3/2

6:20 pm-12:06 am

1 stop6h 46m

$457

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

5:00 pm-11:57 pm

1 stop5h 57m

Florence

ma 3/2

5:16 am-1:19 pm

2 stops9h 03m

$462

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

ke 2/25

3:16 pm-11:08 pm

1 stop6h 52m

Florence

ke 3/4

5:58 pm-12:06 am

1 stop7h 08m

$480

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

ke 2/25

9:40 am-5:21 pm

2 stops6h 41m

Florence

ke 3/4

6:15 am-12:35 pm

1 stop7h 20m

$485

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

ke 2/25

9:40 am-5:21 pm

2 stops6h 41m

Florence

ke 3/4

6:15 am-1:19 pm

2 stops8h 04m

$491

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

6:22 pm-11:57 pm

1 stop4h 35m

Florence

ma 3/2

6:20 pm-12:06 am

1 stop6h 46m

$558

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

10:28 am-5:50 pm

1 stop6h 22m

Florence

ma 3/2

5:16 am-12:05 pm

2 stops7h 49m

$563

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

9:40 am-5:50 pm

2 stops7h 10m

Florence

ma 3/2

5:16 am-12:05 pm

2 stops7h 49m

$637

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

to 2/26

9:40 am-5:50 pm

2 stops7h 10m

Florence

ma 3/2

5:16 am-12:05 pm

2 stops7h 49m

$703

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

su 3/1

4:04 pm-11:57 pm

2 stops6h 53m

Florence

to 3/5

5:16 am-1:19 pm

2 stops9h 03m

$844

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago O'Hare Intl to Florence?

American Airlines is the most popular carrier operating from Chicago O'Hare Intl to Florence

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Chicago O'Hare Intl Airport according to our data. American Airlines is the first choice among our users, with 48% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago O'Hare Intl Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Florence, South Carolina (ORD to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Florence, South Carolina

Fastest flight time

4h 35m

Direct flights

None
The fastest flight from Chicago O'Hare Intl Airport to Florence, South Carolina takes 4h 35m
There are no direct flights from Chicago O'Hare Intl Airport to Florence, South Carolina. There are no popular flight routes from Chicago O'Hare Intl Airport to Florence, South Carolina.
Search flight deals

  • How far is Chicago O'Hare Intl to Florence by plane?

    Chicago O'Hare Intl and Florence are 695.4 mi apart from one another. A reasonable flight in good conditions will take 4h 35m.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Florence Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Chicago.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

All flight searches from Chicago to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to Florence?

momondo helps you find the best flight between Chicago and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Chicago to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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