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Cheap flights from Myrtle Beach to St. Louis from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to St. Louis departing on 6/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
4:05 pm - 10:00 pm
MYR
-
STL
6h 55m
1 stop
Southwest Logo
4:00 pm - 9:05 pm
STL
-
MYR
4h 05m
1 stop
$291Southwest
Tue, Jun 2 - Sat, Jun 6
Southwest Logo
4:05 pm - 10:10 pm
MYR
-
STL
7h 05m
2 stops
Southwest Logo
9:30 am - 4:10 pm
STL
-
MYR
5h 40m
1 stop
$296Southwest
Tue, Jun 2 - Sat, Jun 6
Multiple Airlines Logo
2:42 pm - 11:57 pm
MYR
-
STL
10h 15m
1 stop
Multiple Airlines Logo
6:33 pm - 3:40 pm
STL
-
MYR
20h 07m
2 stops
$309Multiple Airlines
Wed, Jun 3 - Sun, Jun 7
Southwest Logo
4:05 pm - 10:00 pm
MYR
-
STL
6h 55m
1 stop
Southwest Logo
4:45 pm - 7:40 pm
STL
-
MYR
1h 55mnonstop
$328Southwest
Tue, Jun 2 - Sat, Jun 6
Multiple Airlines Logo
9:58 pm - 5:37 pm
MYR
-
STL
20h 39m
2 stops
Multiple Airlines Logo
4:09 pm - 9:05 am
STL
-
MYR
15h 56m
1 stop
$332Multiple Airlines
Sat, Jul 25 - Thu, Jul 30
Delta Logo
4:17 pm - 10:18 pm
MYR
-
STL
7h 01m
1 stop
Delta Logo
9:22 am - 5:06 pm
STL
-
MYR
6h 44m
1 stop
$335Delta
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
6:06 pm - 12:16 am
MYR
-
STL
7h 10m
2 stops
American Airlines Logo
11:18 am - 8:27 pm
STL
-
MYR
8h 09m
1 stop
$340American Airlines
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
6:06 pm - 12:16 am
MYR
-
STL
7h 10m
2 stops
American Airlines Logo
9:09 am - 5:26 pm
STL
-
MYR
7h 17m
2 stops
$345American Airlines
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
4:36 pm - 11:59 pm
MYR
-
STL
8h 23m
1 stop
American Airlines Logo
6:15 am - 12:28 pm
STL
-
MYR
5h 13m
1 stop
$349American Airlines
Wed, May 27 - Fri, May 29
American Airlines Logo
6:06 pm - 11:54 pm
MYR
-
STL
6h 48m
2 stops
American Airlines Logo
6:15 am - 12:28 pm
STL
-
MYR
5h 13m
1 stop
$354American Airlines
Wed, May 27 - Fri, May 29

American Airlines flights from Myrtle Beach to St. Louis

Our best American Airlines deals on Myrtle Beach to St. Louis flight tickets
American Airlines
Jun 24
MYR6:06 pmMyrtle Beach Intl
7h 10m
2 stops
STL12:16 amLambert-St Louis
Jun 30
STL11:18 amLambert-St Louis
8h 09m
1 stop
MYR8:27 pmMyrtle Beach Intl
$340
American Airlines
Jun 24
MYR12:22 pmMyrtle Beach Intl
12h 54m
1 stop
STL12:16 amLambert-St Louis
Jun 30
STL11:18 amLambert-St Louis
6h 02m
1 stop
MYR6:20 pmMyrtle Beach Intl
$349
American Airlines
Jul 14
MYR12:56 pmMyrtle Beach Intl
12h 20m
1 stop
STL12:16 amLambert-St Louis
Jul 19
STL6:00 amLambert-St Louis
4h 35m
1 stop
MYR11:35 amMyrtle Beach Intl
$356

Delta flights from Myrtle Beach to St. Louis

Our best Delta deals on Myrtle Beach to St. Louis flight tickets
Delta
Jun 24
MYR4:17 pmMyrtle Beach Intl
7h 01m
1 stop
STL10:18 pmLambert-St Louis
Jun 30
STL9:22 amLambert-St Louis
6h 44m
1 stop
MYR5:06 pmMyrtle Beach Intl
$335
Delta
Jul 21
MYR11:00 amMyrtle Beach Intl
5h 30m
1 stop
STL3:30 pmLambert-St Louis
Jul 22
STL6:00 amLambert-St Louis
6h 00m
1 stop
MYR1:00 pmMyrtle Beach Intl
$355
Delta
Jun 24
MYR6:00 amMyrtle Beach Intl
4h 46m
1 stop
STL9:46 amLambert-St Louis
Jun 30
STL10:51 amLambert-St Louis
3h 38m
1 stop
MYR3:29 pmMyrtle Beach Intl
$379

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 6/2

4:05 pm-10:00 pm

1 stop6h 55m

Lambert-St Louis

Sat 6/6

4:00 pm-9:05 pm

1 stop4h 05m

$291

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 6/2

4:05 pm-10:10 pm

2 stops7h 05m

Lambert-St Louis

Sat 6/6

9:30 am-4:10 pm

1 stop5h 40m

$296

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 6/3

2:42 pm-11:57 pm

1 stop10h 15m

Lambert-St Louis

Sun 6/7

6:33 pm-3:40 pm

2 stops20h 07m

$309
Quickest round-trip

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 6/2

4:05 pm-10:00 pm

1 stop6h 55m

Lambert-St Louis

Sat 6/6

4:45 pm-7:40 pm

Nonstop1h 55m

$328

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 7/25

9:58 pm-5:37 pm

2 stops20h 39m

Lambert-St Louis

Thu 7/30

4:09 pm-9:05 am

1 stop15h 56m

$332

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 6/24

4:17 pm-10:18 pm

1 stop7h 01m

Lambert-St Louis

Tue 6/30

9:22 am-5:06 pm

1 stop6h 44m

$335

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 6/24

6:06 pm-12:16 am

2 stops7h 10m

Lambert-St Louis

Tue 6/30

11:18 am-8:27 pm

1 stop8h 09m

$340

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 6/24

6:06 pm-12:16 am

2 stops7h 10m

Lambert-St Louis

Tue 6/30

9:09 am-5:26 pm

2 stops7h 17m

$345

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 5/27

4:36 pm-11:59 pm

1 stop8h 23m

Lambert-St Louis

Fri 5/29

6:15 am-12:28 pm

1 stop5h 13m

$349

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Wed 5/27

6:06 pm-11:54 pm

2 stops6h 48m

Lambert-St Louis

Fri 5/29

6:15 am-12:28 pm

1 stop5h 13m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Myrtle Beach to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Myrtle Beach to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $225. The month of June is another great option to travel to St. Louis, with average flight prices from Myrtle Beach averaging around $278.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $401. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $487. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Myrtle Beach in the morning is the least expensive time of day to depart. momondo users have found prices as low as $446 when looking at flights departing in the morning. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $549 per ticket.

What is the cheapest Myrtle Beach Intl to Lambert-St Louis flight route?

Fly from Myrtle Beach Intl to Lambert-St Louis for the best Myrtle Beach Intl - Lambert-St Louis flight prices

How have Myrtle Beach to St. Louis flight prices changed over time?

When to book flights from Myrtle Beach to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to St. Louis (MYR to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to St. Louis

Fastest flight time

2h 00m

Direct flights

Tue, Sat and Sun

Airports in St. Louis

1 airport
The fastest flight from Myrtle Beach to St. Louis takes 2h 00m
Direct flights go from Myrtle Beach to St. Louis on Tuesday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Myrtle Beach there are direct flights to Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from Myrtle Beach to St. Louis

  • How far is Myrtle Beach Intl to Lambert-St Louis by plane?

    There are 716.1 mi between Myrtle Beach Intl and Lambert-St Louis. Typically, this will take 2h 00m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Myrtle Beach to St. Louis?

  • What is the most popular airline from Myrtle Beach to St. Louis?

Best airlines flying from Myrtle Beach to St. Louis

Compare and see reviews for airlines that fly from Myrtle Beach to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $128Free CancellationRating
7.9
8,456 reviews
Search Delta flights
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights
SouthwestPriceFrom $307Free CancellationRating
7.9
4,302 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Wentzville
Alton
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to St. Louis for you.

Can I find flights from Myrtle Beach to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to St. Louis?

Once all potential Myrtle Beach to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

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