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Cheap flights from Myrtle Beach to St. Louis from $106

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to St. Louis departing on 9/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to St. Louis

Cheap round-trip flights

Logo
4:23 pm - 9:40 amMYR-STL
18h 17m1 stop
Logo
4:00 pm - 7:46 pmSTL-MYR
26h 46m2 stops
$249
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Sat, Sep 13 - Mon, Sep 15
Logo
5:20 pm - 1:02 pmMYR-STL
20h 42m1 stop
Logo
1:57 pm - 12:29 pmSTL-MYR
21h 32m1 stop
$253
Find Deal
Thu, Sep 25 - Mon, Sep 29
Delta Logo
10:36 am - 3:55 pmMYR-STL
6h 19m1 stop
Delta Logo
7:05 am - 1:50 pmSTL-MYR
5h 45m1 stop
$295Delta
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Thu, Oct 16 - Tue, Oct 21
Southwest Logo
11:55 am - 1:00 pmMYR-STL
2h 05mnonstop
Southwest Logo
1:50 pm - 7:50 pmSTL-MYR
5h 00m1 stop
$298Southwest
Find Deal
Sat, Sep 13 - Mon, Sep 15
Southwest Logo
3:35 pm - 9:10 pmMYR-STL
6h 35m1 stop
Southwest Logo
6:25 am - 1:30 pmSTL-MYR
6h 05m1 stop
$300Southwest
Find Deal
Sun, Sep 28 - Wed, Oct 1
American Airlines Logo
8:18 pm - 11:53 pmMYR-STL
4h 35m1 stop
American Airlines Logo
7:23 am - 4:48 pmSTL-MYR
8h 25m2 stops
$305American Airlines
Find Deal
Sun, Sep 28 - Wed, Oct 1
American Airlines Logo
6:05 pm - 11:53 pmMYR-STL
6h 48m1 stop
American Airlines Logo
12:52 pm - 7:30 pmSTL-MYR
5h 38m1 stop
$308American Airlines
Find Deal
Sun, Oct 5 - Mon, Oct 6
Spirit Airlines Logo
9:04 pm - 9:40 amMYR-STL
37h 36m2 stops
Spirit Airlines Logo
2:30 pm - 7:53 pmSTL-MYR
4h 23m1 stop
$349Spirit Airlines
Find Deal
Fri, Aug 29 - Mon, Sep 1
Delta Logo
12:35 pm - 8:05 pmMYR-STL
8h 30m1 stop
Delta Logo
5:11 pm - 11:49 pmSTL-MYR
5h 38m1 stop
$360Delta
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Fri, Sep 12 - Sat, Sep 13
Spirit Airlines Logo
8:48 pm - 1:32 pmMYR-STL
17h 44m1 stop
Spirit Airlines Logo
10:35 am - 8:06 pmSTL-MYR
8h 31m1 stop
$361Spirit Airlines
Find Deal
Sun, Aug 31 - Thu, Sep 4

Southwest flights from Myrtle Beach to St. Louis

Our best Southwest deals on Myrtle Beach to St. Louis flight tickets
Southwest
Sep 13
MYR11:55 amMyrtle Beach Intl
2h 05m
STL1:00 pmLambert-St Louis
Sep 15
STL1:50 pmLambert-St Louis
5h 00m
1 stop
MYR7:50 pmMyrtle Beach Intl
$298
Find similar
Southwest
Sep 28
MYR3:35 pmMyrtle Beach Intl
6h 35m
1 stop
STL9:10 pmLambert-St Louis
Oct 1
STL6:25 amLambert-St Louis
6h 05m
1 stop
MYR1:30 pmMyrtle Beach Intl
$300
Find similar
Southwest
Nov 13
MYR5:50 pmMyrtle Beach Intl
6h 05m
1 stop
STL10:55 pmLambert-St Louis
Nov 17
STL8:25 amLambert-St Louis
4h 50m
1 stop
MYR2:15 pmMyrtle Beach Intl
$303
Find similar

American Airlines flights from Myrtle Beach to St. Louis

Our best American Airlines deals on Myrtle Beach to St. Louis flight tickets
American Airlines
Sep 28
MYR8:18 pmMyrtle Beach Intl
4h 35m
1 stop
STL11:53 pmLambert-St Louis
Oct 1
STL7:23 amLambert-St Louis
8h 25m
2 stops
MYR4:48 pmMyrtle Beach Intl
$305
Find similar
American Airlines
Oct 5
MYR6:05 pmMyrtle Beach Intl
6h 48m
1 stop
STL11:53 pmLambert-St Louis
Oct 6
STL12:52 pmLambert-St Louis
5h 38m
1 stop
MYR7:30 pmMyrtle Beach Intl
$308
Find similar
American Airlines
Oct 16
MYR5:59 pmMyrtle Beach Intl
6h 55m
2 stops
STL11:54 pmLambert-St Louis
Oct 21
STL10:22 amLambert-St Louis
5h 38m
1 stop
MYR5:00 pmMyrtle Beach Intl
$352
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Myrtle Beach to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 9/13

4:23 pm-9:40 am

1 stop18h 17m

Lambert-St Louis

Mon 9/15

4:00 pm-7:46 pm

2 stops26h 46m

$249

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 9/25

5:20 pm-1:02 pm

1 stop20h 42m

Lambert-St Louis

Mon 9/29

1:57 pm-12:29 pm

1 stop21h 32m

$253

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 10/16

10:36 am-3:55 pm

1 stop6h 19m

Lambert-St Louis

Tue 10/21

7:05 am-1:50 pm

1 stop5h 45m

$295

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 9/13

11:55 am-1:00 pm

Nonstop2h 05m

Lambert-St Louis

Mon 9/15

1:50 pm-7:50 pm

1 stop5h 00m

$298

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sun 9/28

3:35 pm-9:10 pm

1 stop6h 35m

Lambert-St Louis

Wed 10/1

6:25 am-1:30 pm

1 stop6h 05m

$300

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sun 9/28

8:18 pm-11:53 pm

1 stop4h 35m

Lambert-St Louis

Wed 10/1

7:23 am-4:48 pm

2 stops8h 25m

$305

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sun 10/5

6:05 pm-11:53 pm

1 stop6h 48m

Lambert-St Louis

Mon 10/6

12:52 pm-7:30 pm

1 stop5h 38m

$308

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 8/29

9:04 pm-9:40 am

2 stops37h 36m

Lambert-St Louis

Mon 9/1

2:30 pm-7:53 pm

1 stop4h 23m

$349

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 9/12

12:35 pm-8:05 pm

1 stop8h 30m

Lambert-St Louis

Sat 9/13

5:11 pm-11:49 pm

1 stop5h 38m

$360

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sun 8/31

8:48 pm-1:32 pm

1 stop17h 44m

Lambert-St Louis

Thu 9/4

10:35 am-8:06 pm

1 stop8h 31m

$361

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Myrtle Beach to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Myrtle Beach to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $271. The month of July is another great option to travel to St. Louis, with average flight prices from Myrtle Beach averaging around $322.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $319. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $502. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Myrtle Beach in the evening is the least expensive time of day to depart. momondo users have found prices as low as $341 when looking at flights departing in the evening. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $488 per ticket.

What is the cheapest Myrtle Beach Intl to Lambert-St Louis flight route?

Fly from Myrtle Beach Intl to Lambert-St Louis for the best Myrtle Beach Intl - Lambert-St Louis flight prices

What cabin class options are available on Myrtle Beach Intl to Lambert-St Louis flights?

There are 1 cabin classes available to choose from on Myrtle Beach Intl to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Myrtle Beach to St. Louis flight prices changed over time?

As of August 2025, prices for Myrtle Beach to St. Louis flights are approximately 33% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to St. Louis (MYR to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to St. Louis

Best Price Found

$106

Fastest flight time

2h 05m

Direct flights

Mon and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Myrtle Beach in the past 72 hours is $106. The best round-trip flight deal from Myrtle Beach to St. Louis found on momondo in the last 72 hours is $249.
The fastest flight from Myrtle Beach to St. Louis takes 2h 05m
Direct flights go from Myrtle Beach to St. Louis on Monday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Myrtle Beach Intl to Lambert-St Louis by plane?

    There are 716.1 mi between Myrtle Beach Intl and Lambert-St Louis. Typically, this will take 2h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Myrtle Beach to St. Louis?

  • What is the most popular airline from Myrtle Beach to St. Louis?

Best airlines flying from Myrtle Beach to St. Louis

Compare and see reviews for airlines that fly from Myrtle Beach to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $260Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $292Free CancellationRating
8.0
4,246 reviews
Search Southwest flights

  • Southwest Flights From Myrtle Beach to St. Louis

    The lowest priced Southwest flight from Myrtle Beach to St. Louis from the last 72 hours was $292. Generally, Southwest has 2 flights on this route every week with an average price of $382. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
Maryland Heights
Florissant
O'Fallon
Fenton
Wentzville
Collinsville
Alton
St. Peters
Farmington
Festus
Glencoe
Eureka
Clayton
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to St. Louis for you.

Can I find flights from Myrtle Beach to St. Louis with flexible booking policies on momondo?

momondo does allow users to show only those flights to St. Louis from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to St. Louis?

Once all potential Myrtle Beach to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

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