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Cheap flights from Myrtle Beach to Louisville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Louisville departing on 5/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
9:09 am - 2:38 pm
MYR
-
SDF
29h 29m
1 stop
Spirit Airlines Logo
3:33 pm - 8:13 am
SDF
-
MYR
16h 40m
1 stop
$253Spirit Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
6:15 am - 1:26 pm
MYR
-
SDF
31h 11m
2 stops
Multiple Airlines Logo
3:33 pm - 8:13 am
SDF
-
MYR
16h 40m
1 stop
$301Multiple Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
6:28 pm - 11:47 am
MYR
-
SDF
17h 19m
1 stop
Multiple Airlines Logo
7:48 pm - 10:05 am
SDF
-
MYR
38h 17m
2 stops
$319Multiple Airlines
Mon, Apr 6 - Fri, Apr 10
Delta Logo
2:21 pm - 7:02 pm
MYR
-
SDF
4h 41m
1 stop
Delta Logo
5:35 pm - 12:04 am
SDF
-
MYR
6h 29m
1 stop
$327Delta
Fri, Mar 6 - Mon, Mar 9
American Airlines Logo
3:18 pm - 7:07 pm
MYR
-
SDF
3h 49m
1 stop
American Airlines Logo
7:57 pm - 11:55 pm
SDF
-
MYR
3h 58m
1 stop
$331American Airlines
Wed, Mar 25 - Thu, Mar 26
American Airlines Logo
6:23 pm - 10:43 pm
MYR
-
SDF
4h 20m
1 stop
American Airlines Logo
6:33 am - 2:27 pm
SDF
-
MYR
7h 54m
2 stops
$332American Airlines
Fri, Mar 6 - Mon, Mar 9
American Airlines Logo
9:14 am - 5:18 pm
MYR
-
SDF
8h 04m
2 stops
American Airlines Logo
7:57 pm - 11:55 pm
SDF
-
MYR
3h 58m
1 stop
$336American Airlines
Wed, Mar 25 - Thu, Mar 26
American Airlines Logo
3:17 pm - 11:16 pm
MYR
-
SDF
7h 59m
2 stops
American Airlines Logo
4:50 pm - 11:55 pm
SDF
-
MYR
7h 05m
2 stops
$337American Airlines
Fri, Mar 6 - Mon, Mar 9
American Airlines Logo
5:19 pm - 11:58 pm
MYR
-
SDF
6h 39m
1 stop
American Airlines Logo
6:00 am - 12:04 pm
SDF
-
MYR
6h 04m
1 stop
$347American Airlines
Mon, Apr 6 - Fri, Apr 10
American Airlines Logo
10:36 am - 4:20 pm
MYR
-
SDF
5h 44m
1 stop
American Airlines Logo
4:50 pm - 11:55 pm
SDF
-
MYR
7h 05m
2 stops
$352American Airlines
Fri, Mar 6 - Mon, Mar 9

United Airlines flights from Myrtle Beach to Louisville

Our best United Airlines deals on Myrtle Beach to Louisville flight tickets
United Airlines
Apr 10
MYR5:55 pmMyrtle Beach Intl
5h 17m
1 stop
SDF11:12 pmLouisville Intl
Apr 12
SDF7:20 amLouisville Intl
6h 57m
1 stop
MYR2:17 pmMyrtle Beach Intl
$376
United Airlines
Feb 19
MYR1:00 pmMyrtle Beach Intl
6h 25m
1 stop
SDF7:25 pmLouisville Intl
Feb 22
SDF6:15 amLouisville Intl
6h 04m
1 stop
MYR12:19 pmMyrtle Beach Intl
$463
United Airlines
Feb 19
MYR1:00 pmMyrtle Beach Intl
9h 13m
2 stops
SDF10:13 pmLouisville Intl
Feb 22
SDF6:15 amLouisville Intl
6h 04m
1 stop
MYR12:19 pmMyrtle Beach Intl
$497

Delta flights from Myrtle Beach to Louisville

Our best Delta deals on Myrtle Beach to Louisville flight tickets
Delta
Mar 6
MYR2:21 pmMyrtle Beach Intl
4h 41m
1 stop
SDF7:02 pmLouisville Intl
Mar 9
SDF5:35 pmLouisville Intl
6h 29m
1 stop
MYR12:04 amMyrtle Beach Intl
$327
Delta
Feb 16
MYR6:55 pmMyrtle Beach Intl
3h 52m
1 stop
SDF10:47 pmLouisville Intl
Feb 20
SDF5:33 amLouisville Intl
4h 12m
1 stop
MYR9:45 amMyrtle Beach Intl
$439

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 2/18

9:09 am-2:38 pm

1 stop29h 29m

Louisville Intl

Sun 2/22

3:33 pm-8:13 am

1 stop16h 40m

$253

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 2/18

6:15 am-1:26 pm

2 stops31h 11m

Louisville Intl

Sun 2/22

3:33 pm-8:13 am

1 stop16h 40m

$301

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Mon 4/6

6:28 pm-11:47 am

1 stop17h 19m

Louisville Intl

Fri 4/10

7:48 pm-10:05 am

2 stops38h 17m

$319

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

2:21 pm-7:02 pm

1 stop4h 41m

Louisville Intl

Mon 3/9

5:35 pm-12:04 am

1 stop6h 29m

$327

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 3/25

3:18 pm-7:07 pm

1 stop3h 49m

Louisville Intl

Thu 3/26

7:57 pm-11:55 pm

1 stop3h 58m

$331

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

6:23 pm-10:43 pm

1 stop4h 20m

Louisville Intl

Mon 3/9

6:33 am-2:27 pm

2 stops7h 54m

$332

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 3/25

9:14 am-5:18 pm

2 stops8h 04m

Louisville Intl

Thu 3/26

7:57 pm-11:55 pm

1 stop3h 58m

$336

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

3:17 pm-11:16 pm

2 stops7h 59m

Louisville Intl

Mon 3/9

4:50 pm-11:55 pm

2 stops7h 05m

$337

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Mon 4/6

5:19 pm-11:58 pm

1 stop6h 39m

Louisville Intl

Fri 4/10

6:00 am-12:04 pm

1 stop6h 04m

$347

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Fri 3/6

10:36 am-4:20 pm

1 stop5h 44m

Louisville Intl

Mon 3/9

4:50 pm-11:55 pm

2 stops7h 05m

$352

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Myrtle Beach to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of May, then departing from Myrtle Beach during the month February is also very affordable. Most momondo users find prices during this month for around $256.

What is the cheapest Myrtle Beach Intl to Louisville Intl flight route?

Fly from Myrtle Beach Intl to Louisville Intl for the best Myrtle Beach Intl - Louisville Intl flight prices

What cabin class options are available on Myrtle Beach Intl to Louisville Intl flights?

There is only 1 cabin class available to choose from on Myrtle Beach Intl to Louisville Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Louisville flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Louisville.

How have Myrtle Beach to Louisville flight prices changed over time?

When to book flights from Myrtle Beach to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Louisville (MYR to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Louisville

Fastest flight time

3h 28m

Direct flights

None
The fastest flight from Myrtle Beach to Louisville takes 3h 28m
There are no direct flights from Myrtle Beach to Louisville. There are no popular flight routes from Myrtle Beach to Louisville.
Search flight deals

  • How far is Myrtle Beach Intl to Louisville Intl by plane?

    The straight-line distance from Myrtle Beach Intl to Louisville Intl is 496.1 mi. Flights usually cover this in 3h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

    Prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Louisville Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The required travel and health documents for your Louisville Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Louisville Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Louisville?

  • What is the most popular airline from Myrtle Beach to Louisville?

Best airlines flying from Myrtle Beach to Louisville

Compare and see reviews for airlines that fly from Myrtle Beach to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $127Free CancellationRating
7.9
8,144 reviews
Search Delta flights
American AirlinesPriceFrom $256Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Corydon
Elizabeth
Charlestown
Brandenburg
Springfield
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Louisville?

Finding the right flight to Louisville from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Myrtle Beach on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Myrtle Beach to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Louisville.

I’m not ready to book a flight from Myrtle Beach to Louisville right now. Can momondo alert me if prices change?

Price alerts on flights to Louisville from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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