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Cheap flights from Myrtle Beach to Louisville from $140

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
9:22 am - 2:51 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 29m1 stop Charlotte Douglas
American Airlines Logo
4:35 pm - 10:29 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 54m1 stop Charlotte Douglas
$279American Airlines
Thu, Oct 29 - Mon, Nov 2
United Airlines Logo
12:30 pm - 8:13 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
7h 43m1 stop Newark
United Airlines Logo
10:25 am - 3:16 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 51m1 stop Chicago O'Hare Intl
$279United Airlines
Sat, Sep 26 - Tue, Sep 29
Delta Logo
6:56 pm - 11:59 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 03m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:55 pm - 11:28 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 33m1 stop Atlanta Hartsfield-Jackson
$279Delta
Mon, Sep 28 - Thu, Oct 1
Southwest Logo
3:55 pm - 12:10 amMYR  Myrtle Beach Intl-SDF Louisville Intl
8h 15m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
12:05 pm - 6:55 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
6h 50m1 stop Baltimore/Washington
$284Southwest
Thu, Oct 29 - Mon, Nov 2
Delta Logo
4:30 pm - 10:47 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
6h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:07 amSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$289Delta
Wed, Nov 4 - Fri, Nov 6
Delta Logo
6:00 am - 10:19 amMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 pm - 9:41 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 41m1 stop Atlanta Hartsfield-Jackson
$289Delta
Fri, Oct 2 - Sat, Oct 3
United Airlines Logo
10:23 am - 8:31 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
10h 08m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
6:15 am - 11:38 amSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 23m1 stop Newark
$294United Airlines
Fri, Oct 2 - Sat, Oct 3
United Airlines Logo
10:23 am - 8:31 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
10h 08m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 9:44 amSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 44m1 stop Washington, D.C. Dulles Intl
$296United Airlines
Sat, Sep 26 - Tue, Sep 29
United Airlines Logo
10:23 am - 8:31 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
10h 08m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 9:44 amSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 44m1 stop Washington, D.C. Dulles Intl
$297United Airlines
Sat, Sep 26 - Tue, Sep 29
American Airlines Logo
7:25 pm - 11:22 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
3h 57m1 stop Charlotte Douglas
American Airlines Logo
7:27 pm - 10:53 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 26m1 stop Charlotte Douglas
$304American Airlines
Thu, Sep 24 - Mon, Sep 28

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United Airlines flights from Myrtle Beach to Louisville

Our best United Airlines deals on Myrtle Beach to Louisville flight tickets
United Airlines
Sep 26
MYR12:30 pmMyrtle Beach Intl
7h 43m
1 stop
SDF8:13 pmLouisville Intl
Sep 29
SDF10:25 amLouisville Intl
4h 51m
1 stop
MYR3:16 pmMyrtle Beach Intl
$279
United Airlines
Oct 2
MYR10:23 amMyrtle Beach Intl
10h 08m
2 stops
SDF8:31 pmLouisville Intl
Oct 3
SDF6:15 amLouisville Intl
5h 23m
1 stop
MYR11:38 amMyrtle Beach Intl
$294
United Airlines
Sep 26
MYR10:23 amMyrtle Beach Intl
10h 08m
2 stops
SDF8:31 pmLouisville Intl
Sep 29
SDF6:00 amLouisville Intl
3h 44m
1 stop
MYR9:44 amMyrtle Beach Intl
$296

American Airlines flights from Myrtle Beach to Louisville

Our best American Airlines deals on Myrtle Beach to Louisville flight tickets
American Airlines
Sep 24
MYR7:25 pmMyrtle Beach Intl
3h 57m
1 stop
SDF11:22 pmLouisville Intl
Sep 28
SDF7:27 pmLouisville Intl
3h 26m
1 stop
MYR10:53 pmMyrtle Beach Intl
$304
American Airlines
Sep 24
MYR7:25 pmMyrtle Beach Intl
3h 57m
1 stop
SDF11:22 pmLouisville Intl
Sep 28
SDF7:27 pmLouisville Intl
3h 26m
1 stop
MYR10:53 pmMyrtle Beach Intl
$314
American Airlines
Sep 23
MYR7:25 pmMyrtle Beach Intl
3h 57m
1 stop
SDF11:22 pmLouisville Intl
Sep 28
SDF7:27 pmLouisville Intl
3h 26m
1 stop
MYR10:53 pmMyrtle Beach Intl
$329

momondo Fare Finder

 
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 10/29

9:22 am-2:51 pm

1 stop5h 29m

Louisville Intl

Mon 11/2

4:35 pm-10:29 pm

1 stop5h 54m

$279

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 9/26

12:30 pm-8:13 pm

1 stop7h 43m

Louisville Intl

Tue 9/29

10:25 am-3:16 pm

1 stop4h 51m

$279

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Mon 9/28

6:56 pm-11:59 pm

1 stop5h 03m

Louisville Intl

Thu 10/1

7:55 pm-11:28 pm

1 stop3h 33m

$279

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 10/29

3:55 pm-12:10 am

2 stops8h 15m

Louisville Intl

Mon 11/2

12:05 pm-6:55 pm

1 stop6h 50m

$284

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Wed 11/4

4:30 pm-10:47 pm

1 stop6h 17m

Louisville Intl

Fri 11/6

6:00 am-10:07 am

1 stop4h 07m

$289

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 10/2

6:00 am-10:19 am

1 stop4h 19m

Louisville Intl

Sat 10/3

6:00 pm-9:41 pm

1 stop3h 41m

$289

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 10/2

10:23 am-8:31 pm

2 stops10h 08m

Louisville Intl

Sat 10/3

6:15 am-11:38 am

1 stop5h 23m

$294

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 9/26

10:23 am-8:31 pm

2 stops10h 08m

Louisville Intl

Tue 9/29

6:00 am-9:44 am

1 stop3h 44m

$296

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 9/26

10:23 am-8:31 pm

2 stops10h 08m

Louisville Intl

Tue 9/29

6:00 am-9:44 am

1 stop3h 44m

$297
Quickest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 9/24

7:25 pm-11:22 pm

1 stop3h 57m

Louisville Intl

Mon 9/28

7:27 pm-10:53 pm

1 stop3h 26m

$304

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Myrtle Beach to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Louisville?

Prices are currently low for flights on this route.

Typical prices usually range from $316 to $421.
The lowest price recently found on this route was $279.

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of May, then departing from Myrtle Beach during the month March is also very affordable. Most momondo users find prices during this month for around $0.

What is the cheapest Myrtle Beach Intl to Louisville Intl flight route?

Fly from Myrtle Beach Intl to Louisville Intl for the best Myrtle Beach Intl - Louisville Intl flight prices

What cabin class options are available on Myrtle Beach to Louisville flights?

There is only 1 cabin class available to choose from on Myrtle Beach to Louisville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Louisville flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Louisville.

How have Myrtle Beach to Louisville flight prices changed over time?

As of August 2026, prices for Myrtle Beach to Louisville flights are approximately 47% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Louisville (MYR to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Louisville

Best Price Found

$140

Fastest flight time

5h 01m

Direct flights

None
The best one-way flight to Louisville from Myrtle Beach in the past 72 hours is $140. The best round-trip flight deal from Myrtle Beach to Louisville found on momondo in the last 72 hours is $279.
The fastest flight from Myrtle Beach to Louisville takes 5h 01m
There are no direct flights from Myrtle Beach to Louisville. There are no popular flight routes from Myrtle Beach to Louisville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Louisville

  • How far is Myrtle Beach Intl to Louisville Intl by plane?

    The straight-line distance from Myrtle Beach Intl to Louisville Intl is 496.1 mi. Flights usually cover this in 5h 01m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

    Prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Louisville Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The required travel and health documents for your Louisville Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Louisville Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Louisville?

  • What is the most popular airline from Myrtle Beach to Louisville?

Best airlines flying from Myrtle Beach to Louisville

Compare and see reviews for airlines that fly from Myrtle Beach to Louisville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,983 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
New Albany
Shepherdsville
Elizabeth
Charlestown
Corydon
Brandenburg
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Louisville?

Finding the right flight to Louisville from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Myrtle Beach on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Myrtle Beach to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Louisville.

I’m not ready to book a flight from Myrtle Beach to Louisville right now. Can momondo alert me if prices change?

Price alerts on flights to Louisville from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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