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Cheap flights from Myrtle Beach to Louisville from $183

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:51 pm - 11:13 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:07 amSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$247Delta
Sat, Nov 21 - Mon, Nov 23
Delta Logo
6:51 pm - 11:13 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:55 pm - 9:43 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 48m1 stop Atlanta Hartsfield-Jackson
$247Delta
Sat, Nov 21 - Thu, Nov 26
Delta Logo
6:51 pm - 12:10 amMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:07 amSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$247Delta
Thu, Nov 19 - Mon, Nov 23
Delta Logo
6:51 pm - 10:53 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:55 pm - 9:43 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 48m1 stop Atlanta Hartsfield-Jackson
$247Delta
Thu, Nov 19 - Thu, Nov 26
Delta Logo
6:51 pm - 11:13 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:05 am - 2:56 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 51m1 stop Atlanta Hartsfield-Jackson
$267Delta
Sat, Nov 21 - Fri, Nov 27
Delta Logo
6:51 pm - 12:10 amMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:07 amSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$267Delta
Thu, Nov 19 - Fri, Nov 27
American Airlines Logo
12:02 pm - 5:12 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 10m1 stop Charlotte Douglas
American Airlines Logo
1:02 pm - 4:20 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 18m1 stop Charlotte Douglas
$271American Airlines
Wed, Nov 18 - Wed, Jan 6
Multiple Airlines Logo
6:25 pm - 3:00 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
20h 35m1 stop Tampa
Multiple Airlines Logo
6:49 pm - 8:03 amSDF  Louisville Intl-MYR Myrtle Beach Intl
13h 14m1 stop Fort Lauderdale
$284Multiple Airlines
Sun, Jan 31 - Sun, Feb 7
Delta Logo
6:51 pm - 11:13 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 10:07 amSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$291Delta
Sat, Nov 21 - Sun, Nov 22
American Airlines Logo
8:02 am - 12:18 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 16m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 9:44 amSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 44m1 stop Charlotte Douglas
$295American Airlines
Tue, Feb 2 - Fri, Feb 5

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United Airlines flights from Myrtle Beach to Louisville

Our best United Airlines deals on Myrtle Beach to Louisville flight tickets
United Airlines
Jan 31
MYR6:29 pmMyrtle Beach Intl
5h 11m
1 stop
SDF11:40 pmLouisville Intl
Feb 7
SDF7:00 amLouisville Intl
10h 48m
2 stops
MYR5:48 pmMyrtle Beach Intl
$442
United Airlines
Jan 31
MYR6:29 pmMyrtle Beach Intl
5h 15m
1 stop
SDF11:44 pmLouisville Intl
Feb 7
SDF7:00 amLouisville Intl
10h 48m
2 stops
MYR5:48 pmMyrtle Beach Intl
$452
United Airlines
Nov 10
MYR11:27 amMyrtle Beach Intl
6h 10m
1 stop
SDF5:37 pmLouisville Intl
Nov 14
SDF10:55 amLouisville Intl
6h 16m
1 stop
MYR5:11 pmMyrtle Beach Intl
$599

American Airlines flights from Myrtle Beach to Louisville

Our best American Airlines deals on Myrtle Beach to Louisville flight tickets
American Airlines
Nov 18
MYR12:02 pmMyrtle Beach Intl
5h 10m
1 stop
SDF5:12 pmLouisville Intl
Jan 6
SDF1:02 pmLouisville Intl
3h 18m
1 stop
MYR4:20 pmMyrtle Beach Intl
$271
American Airlines
Feb 2
MYR8:02 amMyrtle Beach Intl
4h 16m
1 stop
SDF12:18 pmLouisville Intl
Feb 5
SDF6:00 amLouisville Intl
3h 44m
1 stop
MYR9:44 amMyrtle Beach Intl
$295
American Airlines
Jan 31
MYR6:12 amMyrtle Beach Intl
6h 06m
1 stop
SDF12:18 pmLouisville Intl
Feb 7
SDF6:00 amLouisville Intl
3h 44m
1 stop
MYR9:44 amMyrtle Beach Intl
$347

momondo Fare Finder

 
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

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Route

Depart

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Price

Cheapest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 11/21

6:51 pm-11:13 pm

1 stop4h 22m

Louisville Intl

Mon 11/23

6:00 am-10:07 am

1 stop4h 07m

$247

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 11/21

6:51 pm-11:13 pm

1 stop4h 22m

Louisville Intl

Thu 11/26

4:55 pm-9:43 pm

1 stop4h 48m

$247

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 11/19

6:51 pm-12:10 am

1 stop5h 19m

Louisville Intl

Mon 11/23

6:00 am-10:07 am

1 stop4h 07m

$247

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 11/19

6:51 pm-10:53 pm

1 stop4h 02m

Louisville Intl

Thu 11/26

4:55 pm-9:43 pm

1 stop4h 48m

$247

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 11/21

6:51 pm-11:13 pm

1 stop4h 22m

Louisville Intl

Fri 11/27

9:05 am-2:56 pm

1 stop5h 51m

$267

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 11/19

6:51 pm-12:10 am

1 stop5h 19m

Louisville Intl

Fri 11/27

6:00 am-10:07 am

1 stop4h 07m

$267

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Wed 11/18

12:02 pm-5:12 pm

1 stop5h 10m

Louisville Intl

Wed 1/6

1:02 pm-4:20 pm

1 stop3h 18m

$271

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sun 1/31

6:25 pm-3:00 pm

1 stop20h 35m

Louisville Intl

Sun 2/7

6:49 pm-8:03 am

1 stop13h 14m

$284

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Sat 11/21

6:51 pm-11:13 pm

1 stop4h 22m

Louisville Intl

Sun 11/22

6:00 am-10:07 am

1 stop4h 07m

$291
Quickest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Tue 2/2

8:02 am-12:18 pm

1 stop4h 16m

Louisville Intl

Fri 2/5

6:00 am-9:44 am

1 stop3h 44m

$295

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest Myrtle Beach Intl to Louisville Intl flight route?

Fly from Myrtle Beach Intl to Louisville Intl for the best Myrtle Beach Intl - Louisville Intl flight prices

What cabin class options are available on Myrtle Beach to Louisville flights?

There is only 1 cabin class available to choose from on Myrtle Beach to Louisville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Louisville flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Louisville.

How have Myrtle Beach to Louisville flight prices changed over time?

As of October 2026, prices for Myrtle Beach to Louisville flights are approximately 365% more expensive when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Louisville (MYR to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Louisville

Best Price Found

$183

Fastest flight time

4h 16m

Direct flights

None
The best one-way flight to Louisville from Myrtle Beach in the past 72 hours is $183. The best round-trip flight deal from Myrtle Beach to Louisville found on momondo in the last 72 hours is $247.
The fastest flight from Myrtle Beach to Louisville takes 4h 16m
There are no direct flights from Myrtle Beach to Louisville. There are no popular flight routes from Myrtle Beach to Louisville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Louisville

  • How far is Myrtle Beach Intl to Louisville Intl by plane?

    The straight-line distance from Myrtle Beach Intl to Louisville Intl is 496.1 mi. Flights usually cover this in 4h 16m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

    Prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Louisville Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The required travel and health documents for your Louisville Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Louisville Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Louisville?

  • What is the most popular airline from Myrtle Beach to Louisville?

Best airlines flying from Myrtle Beach to Louisville

Compare and see reviews for airlines that fly from Myrtle Beach to Louisville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $256Free CancellationRating
7.0
12,209 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
New Albany
Bardstown
Shepherdsville
Elizabeth
Charlestown
Corydon
Brandenburg
Springfield
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Louisville?

Finding the right flight to Louisville from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Myrtle Beach on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Myrtle Beach to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Louisville.

I’m not ready to book a flight from Myrtle Beach to Louisville right now. Can momondo alert me if prices change?

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