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Cheap flights from Myrtle Beach to Louisville from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Louisville departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Breeze Airways Logo
8:41 pm - 8:06 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
23h 25m2 stops Tampa Raleigh-Durham
Breeze Airways Logo
10:35 am - 8:48 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
10h 13m1 stop Hartford Bradley Intl
$281Breeze Airways
Fri, Sep 4 - Mon, Sep 7
Delta Logo
10:55 am - 4:51 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 56m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:53 pm - 5:55 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 02m1 stop Atlanta Hartsfield-Jackson
$289Delta
Fri, Dec 25 - Tue, Jan 5
Delta Logo
2:15 pm - 7:01 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
4h 46m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:53 pm - 5:55 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 02m1 stop Atlanta Hartsfield-Jackson
$289Delta
Fri, Dec 25 - Thu, Jan 7
Delta Logo
6:45 pm - 12:02 amMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:45 pm - 11:35 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 50m1 stop Atlanta Hartsfield-Jackson
$289Delta
Fri, Dec 25 - Wed, Jan 6
American Airlines Logo
7:25 pm - 11:22 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
3h 57m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 11:37 amSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 37m1 stop Washington, D.C. Reagan-National
$299American Airlines
Thu, Sep 24 - Tue, Sep 29
American Airlines Logo
12:08 pm - 3:49 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
3h 41m1 stop Charlotte Douglas
American Airlines Logo
6:00 am - 11:24 amSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 24m1 stop Washington, D.C. Reagan-National
$299American Airlines
Tue, Oct 6 - Wed, Oct 14
United Airlines Logo
6:21 pm - 11:59 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 38m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 9:44 amSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 44m1 stop Washington, D.C. Dulles Intl
$299United Airlines
Tue, Sep 1 - Mon, Sep 7
Delta Logo
2:15 pm - 8:51 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
6h 36m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:30 pm - 11:35 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
4h 05m1 stop Atlanta Hartsfield-Jackson
$299Delta
Thu, Dec 24 - Wed, Jan 6
Delta Logo
6:45 pm - 12:02 amMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:45 pm - 11:35 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
5h 50m1 stop Atlanta Hartsfield-Jackson
$299Delta
Wed, Dec 30 - Thu, Jan 7
Delta Logo
6:56 pm - 11:59 pmMYR  Myrtle Beach Intl-SDF Louisville Intl
5h 03m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:55 pm - 11:28 pmSDF  Louisville Intl-MYR Myrtle Beach Intl
3h 33m1 stop Atlanta Hartsfield-Jackson
$299Delta
Mon, Sep 28 - Thu, Oct 1

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Southwest flights from Myrtle Beach to Louisville

Our best Southwest deals on Myrtle Beach to Louisville flight tickets
Southwest
Sep 28
MYR1:55 pmMyrtle Beach Intl
6h 40m
2 stops
SDF8:35 pmLouisville Intl
Oct 1
SDF6:15 pmLouisville Intl
3h 25m
1 stop
MYR9:40 pmMyrtle Beach Intl
$319
Southwest
Sep 26
MYR11:45 amMyrtle Beach Intl
9h 25m
2 stops
SDF9:10 pmLouisville Intl
Sep 27
SDF4:10 pmLouisville Intl
5h 20m
1 stop
MYR9:30 pmMyrtle Beach Intl
$333
Southwest
Sep 9
MYR8:15 amMyrtle Beach Intl
7h 00m
2 stops
SDF3:15 pmLouisville Intl
Sep 13
SDF4:05 pmLouisville Intl
5h 25m
1 stop
MYR9:30 pmMyrtle Beach Intl
$358

American Airlines flights from Myrtle Beach to Louisville

Our best American Airlines deals on Myrtle Beach to Louisville flight tickets
American Airlines
Aug 26
MYR7:33 pmMyrtle Beach Intl
3h 38m
1 stop
SDF11:11 pmLouisville Intl
Sep 2
SDF7:12 pmLouisville Intl
3h 26m
1 stop
MYR10:38 pmMyrtle Beach Intl
$314
American Airlines
Aug 25
MYR5:15 pmMyrtle Beach Intl
5h 56m
1 stop
SDF11:11 pmLouisville Intl
Sep 25
SDF6:00 amLouisville Intl
5h 37m
1 stop
MYR11:37 amMyrtle Beach Intl
$329
American Airlines
Sep 18
MYR7:25 pmMyrtle Beach Intl
3h 57m
1 stop
SDF11:22 pmLouisville Intl
Sep 20
SDF6:00 amLouisville Intl
5h 37m
1 stop
MYR11:37 amMyrtle Beach Intl
$343

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 9/4

8:41 pm-8:06 pm

2 stops23h 25m

Louisville Intl

Mon 9/7

10:35 am-8:48 pm

1 stop10h 13m

$281

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 12/25

10:55 am-4:51 pm

1 stop5h 56m

Louisville Intl

Tue 1/5

12:53 pm-5:55 pm

1 stop5h 02m

$289

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 12/25

2:15 pm-7:01 pm

1 stop4h 46m

Louisville Intl

Thu 1/7

12:53 pm-5:55 pm

1 stop5h 02m

$289

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Fri 12/25

6:45 pm-12:02 am

1 stop5h 17m

Louisville Intl

Wed 1/6

5:45 pm-11:35 pm

1 stop5h 50m

$289

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 9/24

7:25 pm-11:22 pm

1 stop3h 57m

Louisville Intl

Tue 9/29

6:00 am-11:37 am

1 stop5h 37m

$299

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Tue 10/6

12:08 pm-3:49 pm

1 stop3h 41m

Louisville Intl

Wed 10/14

6:00 am-11:24 am

1 stop5h 24m

$299

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Tue 9/1

6:21 pm-11:59 pm

1 stop5h 38m

Louisville Intl

Mon 9/7

6:00 am-9:44 am

1 stop3h 44m

$299

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Thu 12/24

2:15 pm-8:51 pm

1 stop6h 36m

Louisville Intl

Wed 1/6

7:30 pm-11:35 pm

1 stop4h 05m

$299

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Wed 12/30

6:45 pm-12:02 am

1 stop5h 17m

Louisville Intl

Thu 1/7

5:45 pm-11:35 pm

1 stop5h 50m

$299
Quickest round-trip

Myrtle BeachLouisville

MYR Myrtle Beach Intl - SDF Louisville Intl

MYRSDF

Myrtle Beach Intl

Mon 9/28

6:56 pm-11:59 pm

1 stop5h 03m

Louisville Intl

Thu 10/1

7:55 pm-11:28 pm

1 stop3h 33m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Myrtle Beach to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of May, then departing from Myrtle Beach during the month March is also very affordable. Most momondo users find prices during this month for around $0.

What is the cheapest Myrtle Beach Intl to Louisville Intl flight route?

Fly from Myrtle Beach Intl to Louisville Intl for the best Myrtle Beach Intl - Louisville Intl flight prices

What cabin class options are available on Myrtle Beach to Louisville flights?

There is only 1 cabin class available to choose from on Myrtle Beach to Louisville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Louisville flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Louisville.

How have Myrtle Beach to Louisville flight prices changed over time?

As of August 2026, prices for Myrtle Beach to Louisville flights are approximately 47% cheaper when compared to flights at the same time last year.

When to book flights from Myrtle Beach to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Louisville (MYR to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Louisville

Fastest flight time

3h 38m

Direct flights

None
The fastest flight from Myrtle Beach to Louisville takes 3h 38m
There are no direct flights from Myrtle Beach to Louisville. There are no popular flight routes from Myrtle Beach to Louisville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Louisville

  • How far is Myrtle Beach Intl to Louisville Intl by plane?

    The straight-line distance from Myrtle Beach Intl to Louisville Intl is 496.1 mi. Flights usually cover this in 3h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

    Prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Louisville Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The required travel and health documents for your Louisville Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Louisville Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Louisville?

  • What is the most popular airline from Myrtle Beach to Louisville?

Best airlines flying from Myrtle Beach to Louisville

Compare and see reviews for airlines that fly from Myrtle Beach to Louisville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,877 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
New Albany
Shepherdsville
Elizabeth
Charlestown
Corydon
Brandenburg
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Louisville?

Finding the right flight to Louisville from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Myrtle Beach on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Myrtle Beach to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Louisville.

I’m not ready to book a flight from Myrtle Beach to Louisville right now. Can momondo alert me if prices change?

Price alerts on flights to Louisville from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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