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Cheap flights from Myrtle Beach to Louisville from $264

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Louisville departing on 1/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 9:28 am
MYR
-
SDF
3h 28m1 stop
Delta Logo
6:00 am - 11:42 am
SDF
-
MYR
5h 42m1 stop
$264Delta
Tue, Jan 13 - Thu, Jan 15
American Airlines Logo
1:53 pm - 11:19 pm
MYR
-
SDF
9h 26m2 stops
American Airlines Logo
7:20 pm - 11:15 pm
SDF
-
MYR
3h 55m1 stop
$269American Airlines
Tue, Jan 13 - Thu, Jan 15
American Airlines Logo
1:53 pm - 9:16 pm
MYR
-
SDF
7h 23m2 stops
American Airlines Logo
1:32 pm - 8:54 pm
SDF
-
MYR
7h 22m2 stops
$288American Airlines
Tue, Jan 13 - Thu, Jan 15
United Airlines Logo
5:30 pm - 11:59 pm
MYR
-
SDF
6h 29m1 stop
United Airlines Logo
6:15 am - 11:45 am
SDF
-
MYR
5h 30m1 stop
$303United Airlines
Wed, Feb 18 - Sat, Feb 21
United Airlines Logo
5:30 pm - 11:59 pm
MYR
-
SDF
6h 29m1 stop
United Airlines Logo
5:35 am - 4:32 pm
SDF
-
MYR
10h 57m2 stops
$320United Airlines
Wed, Feb 18 - Sat, Feb 21
United Airlines Logo
5:30 pm - 11:59 pm
MYR
-
SDF
6h 29m1 stop
United Airlines Logo
5:35 am - 4:32 pm
SDF
-
MYR
10h 57m2 stops
$325United Airlines
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
5:11 am - 8:50 am
MYR
-
SDF
3h 39m1 stop
American Airlines Logo
5:00 am - 9:20 am
SDF
-
MYR
4h 20m1 stop
$334American Airlines
Wed, Dec 31 - Fri, Jan 2
American Airlines Logo
5:11 am - 8:50 am
MYR
-
SDF
3h 39m1 stop
American Airlines Logo
6:27 am - 2:04 pm
SDF
-
MYR
7h 37m2 stops
$339American Airlines
Wed, Dec 31 - Fri, Jan 2
American Airlines Logo
12:48 pm - 9:54 pm
MYR
-
SDF
9h 06m2 stops
American Airlines Logo
6:03 am - 12:18 pm
SDF
-
MYR
6h 15m2 stops
$366American Airlines
Wed, Dec 31 - Fri, Jan 2
American Airlines Logo
2:34 pm - 6:21 pm
MYR
-
SDF
3h 47m1 stop
American Airlines Logo
5:00 am - 9:20 am
SDF
-
MYR
4h 20m1 stop
$413American Airlines
Wed, Dec 24 - Sun, Dec 28

United Airlines flights from Myrtle Beach to Louisville

Our best United Airlines deals on Myrtle Beach to Louisville flight tickets
United Airlines
Feb 18
MYR5:30 pmMyrtle Beach Intl
6h 29m
1 stop
SDF11:59 pmLouisville Intl
Feb 21
SDF6:15 amLouisville Intl
5h 30m
1 stop
MYR11:45 amMyrtle Beach Intl
$303
Find similar
United Airlines
Feb 18
MYR5:30 pmMyrtle Beach Intl
6h 29m
1 stop
SDF11:59 pmLouisville Intl
Feb 21
SDF5:35 amLouisville Intl
10h 57m
2 stops
MYR4:32 pmMyrtle Beach Intl
$320
Find similar
United Airlines
Feb 18
MYR5:30 pmMyrtle Beach Intl
6h 29m
1 stop
SDF11:59 pmLouisville Intl
Feb 21
SDF5:35 amLouisville Intl
10h 57m
2 stops
MYR4:32 pmMyrtle Beach Intl
$325
Find similar

Southwest flights from Myrtle Beach to Louisville

Our best Southwest deals on Myrtle Beach to Louisville flight tickets
Southwest
Dec 26
MYR8:20 pmMyrtle Beach Intl
4h 10m
1 stop
SDF12:30 amLouisville Intl
Dec 28
SDF6:20 amLouisville Intl
13h 20m
2 stops
MYR7:40 pmMyrtle Beach Intl
$608
Find similar
Southwest
Dec 26
MYR7:00 amMyrtle Beach Intl
11h 25m
2 stops
SDF6:25 pmLouisville Intl
Dec 28
SDF6:20 amLouisville Intl
13h 20m
2 stops
MYR7:40 pmMyrtle Beach Intl
$671
Find similar
Southwest
Dec 26
MYR7:00 amMyrtle Beach Intl
11h 25m
2 stops
SDF6:25 pmLouisville Intl
Dec 28
SDF6:20 amLouisville Intl
11h 15m
2 stops
MYR5:35 pmMyrtle Beach Intl
$679
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 1/13

6:00 am-9:28 am

1 stop3h 28m

Louisville Intl

Thu 1/15

6:00 am-11:42 am

1 stop5h 42m

$264

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 1/13

1:53 pm-11:19 pm

2 stops9h 26m

Louisville Intl

Thu 1/15

7:20 pm-11:15 pm

1 stop3h 55m

$269

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 1/13

1:53 pm-9:16 pm

2 stops7h 23m

Louisville Intl

Thu 1/15

1:32 pm-8:54 pm

2 stops7h 22m

$288

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 2/18

5:30 pm-11:59 pm

1 stop6h 29m

Louisville Intl

Sat 2/21

6:15 am-11:45 am

1 stop5h 30m

$303

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 2/18

5:30 pm-11:59 pm

1 stop6h 29m

Louisville Intl

Sat 2/21

5:35 am-4:32 pm

2 stops10h 57m

$320

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 2/18

5:30 pm-11:59 pm

1 stop6h 29m

Louisville Intl

Sat 2/21

5:35 am-4:32 pm

2 stops10h 57m

$325

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 12/31

5:11 am-8:50 am

1 stop3h 39m

Louisville Intl

Fri 1/2

5:00 am-9:20 am

1 stop4h 20m

$334

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 12/31

5:11 am-8:50 am

1 stop3h 39m

Louisville Intl

Fri 1/2

6:27 am-2:04 pm

2 stops7h 37m

$339

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 12/31

12:48 pm-9:54 pm

2 stops9h 06m

Louisville Intl

Fri 1/2

6:03 am-12:18 pm

2 stops6h 15m

$366

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Wed 12/24

2:34 pm-6:21 pm

1 stop3h 47m

Louisville Intl

Sun 12/28

5:00 am-9:20 am

1 stop4h 20m

$413

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Louisville from

How to get the cheapest flight ticket from Myrtle Beach to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of May, then departing from Myrtle Beach during the month June is also very affordable. Most momondo users find prices during this month for around $280.

What is the cheapest day to depart on your flight to Louisville?

On average, the least expensive day to fly to Louisville from Myrtle Beach is on a Saturday. momondo users have found tickets for Saturday departures for as low as $143. However, this price may fluctuate depending on the airline, the season, and holidays. Flights from Myrtle Beach to Louisville on a Sunday will generally be more expensive and average around $390. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Louisville?

Our data shows that the cheapest Myrtle Beach to Louisville flights are usually those with departure times in the afternoon. Our users have found flights to Louisville in the afternoon for as low as $133. In the evening is when there is more demand to fly to Louisville, so prices are often more expensive at around $308 per ticket.

What is the cheapest Myrtle Beach Intl to Louisville Intl flight route?

Fly from Myrtle Beach Intl to Louisville Intl for the best Myrtle Beach Intl - Louisville Intl flight prices

What cabin class options are available on Myrtle Beach Intl to Louisville Intl flights?

There is only 1 cabin class available to choose from on Myrtle Beach Intl to Louisville Intl flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Myrtle Beach to Louisville flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Louisville.

When to book flights from Myrtle Beach to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Louisville (MYR to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Louisville

Fastest flight time

3h 28m

Direct flights

None
The fastest flight from Myrtle Beach to Louisville takes 3h 28m
There are no direct flights from Myrtle Beach to Louisville. There are no popular flight routes from Myrtle Beach to Louisville.
Search flight deals

  • How far is Myrtle Beach Intl to Louisville Intl by plane?

    The straight-line distance from Myrtle Beach Intl to Louisville Intl is 496.1 mi. Flights usually cover this in 3h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

    Prices for flights from Myrtle Beach Intl Airport to Louisville Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Louisville Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The required travel and health documents for your Louisville Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Louisville Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Myrtle Beach to Louisville?

  • What is the most popular airline from Myrtle Beach to Louisville?

Best airlines flying from Myrtle Beach to Louisville

Compare and see reviews for airlines that fly from Myrtle Beach to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
8,010 reviews
Search Delta flights
American AirlinesPriceFrom $256Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Elizabeth
Corydon
Charlestown
Springfield
Brandenburg
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Louisville?

Finding the right flight to Louisville from Myrtle Beach is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from Myrtle Beach to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Myrtle Beach on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Myrtle Beach to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Louisville.

I’m not ready to book a flight from Myrtle Beach to Louisville right now. Can momondo alert me if prices change?

Price alerts on flights to Louisville from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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