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Cheap flights from Myrtle Beach to Santo Domingo from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Santo Domingo departing on 3/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:43 pm - 5:29 am
MYR
-
SDQ
8h 46m
1 stop
Multiple Airlines Logo
2:35 pm - 8:58 pm
SDQ
-
MYR
6h 23m
1 stop
$385Multiple Airlines
Sun, May 3 - Sun, May 10
Multiple Airlines Logo
8:43 pm - 5:29 am
MYR
-
SDQ
8h 46m
1 stop
Multiple Airlines Logo
2:35 pm - 8:58 pm
SDQ
-
MYR
6h 23m
1 stop
$421Multiple Airlines
Sun, May 3 - Sat, May 9
Spirit Airlines Logo
3:32 pm - 1:29 pm
MYR
-
SDQ
21h 57m
2 stops
Spirit Airlines Logo
2:35 pm - 8:58 pm
SDQ
-
MYR
6h 23m
1 stop
$441Spirit Airlines
Sun, May 3 - Sat, May 9
Multiple Airlines Logo
8:43 pm - 5:29 am
MYR
-
SDQ
8h 46m
1 stop
Multiple Airlines Logo
2:35 pm - 11:39 am
SDQ
-
MYR
21h 04m
2 stops
$466Multiple Airlines
Sun, May 3 - Sun, May 10
Spirit Airlines Logo
10:20 am - 1:29 pm
MYR
-
SDQ
27h 09m
3 stops
Spirit Airlines Logo
2:35 pm - 8:58 pm
SDQ
-
MYR
6h 23m
1 stop
$497Spirit Airlines
Sun, May 3 - Sat, May 9
Multiple Airlines Logo
4:15 pm - 5:29 am
MYR
-
SDQ
13h 14m
1 stop
Multiple Airlines Logo
3:30 pm - 2:20 pm
SDQ
-
MYR
22h 50m
2 stops
$531Multiple Airlines
Tue, May 26 - Sun, May 31
Multiple Airlines Logo
4:15 pm - 5:29 am
MYR
-
SDQ
13h 14m
1 stop
Multiple Airlines Logo
2:35 pm - 2:20 pm
SDQ
-
MYR
23h 45m
1 stop
$537Multiple Airlines
Tue, May 26 - Sun, May 31
Spirit Airlines Logo
10:20 am - 1:29 pm
MYR
-
SDQ
27h 09m
3 stops
Spirit Airlines Logo
2:35 pm - 8:30 am
SDQ
-
MYR
17h 55m
2 stops
$543Spirit Airlines
Sun, May 3 - Sat, May 9
American Airlines Logo
8:46 pm - 10:55 am
MYR
-
SDQ
14h 09m
2 stops
American Airlines Logo
5:25 pm - 10:10 am
SDQ
-
MYR
16h 45m
2 stops
$593American Airlines
Mon, Sep 14 - Mon, Sep 21
Multiple Airlines Logo
10:20 am - 1:29 pm
MYR
-
SDQ
27h 09m
3 stops
Multiple Airlines Logo
3:30 pm - 8:58 pm
SDQ
-
MYR
29h 28m
3 stops
$594Multiple Airlines
Sun, May 3 - Sat, May 9

American Airlines flights from Myrtle Beach to Santo Domingo

Our best American Airlines deals on Myrtle Beach to Santo Domingo flight tickets
American Airlines
Sep 14
MYR8:46 pmMyrtle Beach Intl
14h 09m
2 stops
SDQ10:55 amSanto Domingo Las Americas
Sep 21
SDQ5:25 pmSanto Domingo Las Americas
16h 45m
2 stops
MYR10:10 amMyrtle Beach Intl
$593
American Airlines
May 3
MYR5:00 amMyrtle Beach Intl
17h 52m
2 stops
SDQ10:52 pmSanto Domingo Las Americas
May 10
SDQ6:00 amSanto Domingo Las Americas
17h 57m
2 stops
MYR11:57 pmMyrtle Beach Intl
$598
American Airlines
May 25
MYR8:41 pmMyrtle Beach Intl
12h 43m
2 stops
SDQ9:24 amSanto Domingo Las Americas
May 30
SDQ7:00 amSanto Domingo Las Americas
16h 50m
2 stops
MYR11:50 pmMyrtle Beach Intl
$613

Delta flights from Myrtle Beach to Santo Domingo

Our best Delta deals on Myrtle Beach to Santo Domingo flight tickets
Delta
May 7
MYR6:00 amMyrtle Beach Intl
7h 24m
1 stop
SDQ1:24 pmSanto Domingo Las Americas
May 11
SDQ2:49 pmSanto Domingo Las Americas
9h 09m
1 stop
MYR11:58 pmMyrtle Beach Intl
$599
Delta
May 7
MYR11:32 amMyrtle Beach Intl
13h 06m
2 stops
SDQ12:38 amSanto Domingo Las Americas
May 11
SDQ2:49 pmSanto Domingo Las Americas
9h 09m
1 stop
MYR11:58 pmMyrtle Beach Intl
$603
Delta
May 25
MYR6:00 amMyrtle Beach Intl
7h 23m
1 stop
SDQ1:23 pmSanto Domingo Las Americas
May 30
SDQ2:48 pmSanto Domingo Las Americas
9h 10m
1 stop
MYR11:58 pmMyrtle Beach Intl
$936

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

8:43 pm-5:29 am

1 stop8h 46m

Santo Domingo Las Americas

Sun 5/10

2:35 pm-8:58 pm

1 stop6h 23m

$385

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

8:43 pm-5:29 am

1 stop8h 46m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:58 pm

1 stop6h 23m

$421

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

3:32 pm-1:29 pm

2 stops21h 57m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:58 pm

1 stop6h 23m

$441

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

8:43 pm-5:29 am

1 stop8h 46m

Santo Domingo Las Americas

Sun 5/10

2:35 pm-11:39 am

2 stops21h 04m

$466

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

10:20 am-1:29 pm

3 stops27h 09m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:58 pm

1 stop6h 23m

$497

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/26

4:15 pm-5:29 am

1 stop13h 14m

Santo Domingo Las Americas

Sun 5/31

3:30 pm-2:20 pm

2 stops22h 50m

$531

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/26

4:15 pm-5:29 am

1 stop13h 14m

Santo Domingo Las Americas

Sun 5/31

2:35 pm-2:20 pm

1 stop23h 45m

$537

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

10:20 am-1:29 pm

3 stops27h 09m

Santo Domingo Las Americas

Sat 5/9

2:35 pm-8:30 am

2 stops17h 55m

$543

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Mon 9/14

8:46 pm-10:55 am

2 stops14h 09m

Santo Domingo Las Americas

Mon 9/21

5:25 pm-10:10 am

2 stops16h 45m

$593

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sun 5/3

10:20 am-1:29 pm

3 stops27h 09m

Santo Domingo Las Americas

Sat 5/9

3:30 pm-8:58 pm

3 stops29h 28m

$594

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Myrtle Beach to Santo Domingo flights?

You could potentially save up to 56% on your flight if you consider stops on a Myrtle Beach to Santo Domingo flight.

When to book flights from Myrtle Beach to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santo Domingo (MYR to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santo Domingo

Fastest flight time

8h 46m

Direct flights

None
The fastest flight from Myrtle Beach to Santo Domingo takes 8h 46m
There are no direct flights from Myrtle Beach to Santo Domingo. There are no popular flight routes from Myrtle Beach to Santo Domingo.
Search flight deals

  • How far is Myrtle Beach Intl to Santo Domingo Las Americas by plane?

    A flight from Myrtle Beach Intl to Santo Domingo Las Americas will travel around 1186.3 mi. 8h 46m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santo Domingo?

Best airlines flying from Myrtle Beach to Santo Domingo

Compare and see reviews for airlines that fly from Myrtle Beach to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.9
8,314 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Santo Domingo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santo Domingo from Myrtle Beach.

Can I find flights from Myrtle Beach to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Santo Domingo?

Once you have performed a search for Myrtle Beach to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Myrtle Beach to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Myrtle Beach to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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