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Cheap flights from Myrtle Beach to Santo Domingo from $192

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Santo Domingo departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to Santo Domingo (MYR-SDQ)

Cheap round-trip flights

Logo
7:36 pm - 4:30 pmMYR-SDQ
20h 54m1 stop
Logo
3:59 pm - 5:44 pmSDQ-MYR
25h 45m2 stops
$424
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Sat, Oct 4 - Sat, Oct 11
Logo
7:36 pm - 4:30 pmMYR-SDQ
20h 54m1 stop
Logo
3:59 pm - 8:04 pmSDQ-MYR
28h 05m1 stop
$426
Find Deal
Sat, Oct 4 - Sat, Oct 11
Spirit Airlines Logo
9:05 pm - 2:54 pmMYR-SDQ
17h 49m1 stop
Spirit Airlines Logo
6:55 pm - 12:24 pmSDQ-MYR
18h 29m2 stops
$431Spirit Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Spirit Airlines Logo
9:05 pm - 2:54 pmMYR-SDQ
17h 49m1 stop
Spirit Airlines Logo
6:55 pm - 10:41 amSDQ-MYR
16h 46m1 stop
$433Spirit Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
Spirit Airlines Logo
6:43 pm - 2:54 pmMYR-SDQ
20h 11m2 stops
Spirit Airlines Logo
6:55 pm - 12:24 pmSDQ-MYR
18h 29m2 stops
$468Spirit Airlines
Find Deal
Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
7:36 pm - 1:35 pmMYR-SDQ
17h 59m2 stops
American Airlines Logo
7:00 am - 9:26 pmSDQ-MYR
14h 26m2 stops
$479American Airlines
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Sat, Oct 4 - Sat, Oct 11
Logo
4:23 pm - 9:45 pmMYR-SDQ
29h 22m3 stops
Logo
3:59 pm - 12:17 pmSDQ-MYR
20h 18m2 stops
$522
Find Deal
Sat, Oct 4 - Sat, Oct 11
Logo
4:23 pm - 9:45 pmMYR-SDQ
29h 22m3 stops
Logo
3:59 pm - 12:48 pmSDQ-MYR
20h 49m3 stops
$528
Find Deal
Sat, Oct 4 - Sat, Oct 11
Logo
4:23 pm - 9:45 pmMYR-SDQ
29h 22m3 stops
Logo
2:05 am - 8:04 pmSDQ-MYR
17h 59m3 stops
$677
Find Deal
Sat, Oct 4 - Fri, Oct 10
Logo
7:36 pm - 2:48 pmMYR-SDQ
19h 12m2 stops
Logo
2:05 am - 8:04 pmSDQ-MYR
17h 59m3 stops
$726
Find Deal
Sat, Oct 4 - Fri, Oct 10

Spirit Airlines flights from Myrtle Beach to Santo Domingo

Our best Spirit Airlines deals on Myrtle Beach to Santo Domingo flight tickets
Spirit Airlines
Oct 31
MYR9:05 pmMyrtle Beach Intl
17h 49m
1 stop
SDQ2:54 pmSanto Domingo Las Americas
Nov 7
SDQ6:55 pmSanto Domingo Las Americas
18h 29m
2 stops
MYR12:24 pmMyrtle Beach Intl
$431
Find similar
Spirit Airlines
Oct 31
MYR9:05 pmMyrtle Beach Intl
17h 49m
1 stop
SDQ2:54 pmSanto Domingo Las Americas
Nov 7
SDQ6:55 pmSanto Domingo Las Americas
16h 46m
1 stop
MYR10:41 amMyrtle Beach Intl
$433
Find similar
Spirit Airlines
Aug 25
MYR7:26 pmMyrtle Beach Intl
20h 34m
1 stop
SDQ4:00 pmSanto Domingo Las Americas
Sep 25
SDQ5:05 pmSanto Domingo Las Americas
27h 01m
1 stop
MYR8:06 pmMyrtle Beach Intl
$456
Find similar

American Airlines flights from Myrtle Beach to Santo Domingo

Our best American Airlines deals on Myrtle Beach to Santo Domingo flight tickets
American Airlines
Oct 4
MYR7:36 pmMyrtle Beach Intl
17h 59m
2 stops
SDQ1:35 pmSanto Domingo Las Americas
Oct 11
SDQ7:00 amSanto Domingo Las Americas
14h 26m
2 stops
MYR9:26 pmMyrtle Beach Intl
$479
Find similar
American Airlines
Aug 25
MYR8:08 amMyrtle Beach Intl
12h 22m
2 stops
SDQ8:30 pmSanto Domingo Las Americas
Sep 25
SDQ12:15 pmSanto Domingo Las Americas
11h 39m
2 stops
MYR11:54 pmMyrtle Beach Intl
$494
Find similar
American Airlines
Aug 25
MYR6:10 amMyrtle Beach Intl
12h 10m
2 stops
SDQ6:20 pmSanto Domingo Las Americas
Aug 29
SDQ7:05 amSanto Domingo Las Americas
10h 53m
2 stops
MYR5:58 pmMyrtle Beach Intl
$519
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momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

7:36 pm-4:30 pm

1 stop20h 54m

Santo Domingo Las Americas

Sat 10/11

3:59 pm-5:44 pm

2 stops25h 45m

$424

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

7:36 pm-4:30 pm

1 stop20h 54m

Santo Domingo Las Americas

Sat 10/11

3:59 pm-8:04 pm

1 stop28h 05m

$426

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 10/31

9:05 pm-2:54 pm

1 stop17h 49m

Santo Domingo Las Americas

Fri 11/7

6:55 pm-12:24 pm

2 stops18h 29m

$431

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 10/31

9:05 pm-2:54 pm

1 stop17h 49m

Santo Domingo Las Americas

Fri 11/7

6:55 pm-10:41 am

1 stop16h 46m

$433

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 10/31

6:43 pm-2:54 pm

2 stops20h 11m

Santo Domingo Las Americas

Fri 11/7

6:55 pm-12:24 pm

2 stops18h 29m

$468

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

7:36 pm-1:35 pm

2 stops17h 59m

Santo Domingo Las Americas

Sat 10/11

7:00 am-9:26 pm

2 stops14h 26m

$479

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

4:23 pm-9:45 pm

3 stops29h 22m

Santo Domingo Las Americas

Sat 10/11

3:59 pm-12:17 pm

2 stops20h 18m

$522

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

4:23 pm-9:45 pm

3 stops29h 22m

Santo Domingo Las Americas

Sat 10/11

3:59 pm-12:48 pm

3 stops20h 49m

$528

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

4:23 pm-9:45 pm

3 stops29h 22m

Santo Domingo Las Americas

Fri 10/10

2:05 am-8:04 pm

3 stops17h 59m

$677

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 10/4

7:36 pm-2:48 pm

2 stops19h 12m

Santo Domingo Las Americas

Fri 10/10

2:05 am-8:04 pm

3 stops17h 59m

$726

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Santo Domingo?

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Wednesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $390. The most expensive day to fly to Santo Domingo is Saturday, with ticket prices averaging around $880.

When to book flights from Myrtle Beach to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santo Domingo (MYR to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santo Domingo

Direct flights

None
There are no direct flights from Myrtle Beach to Santo Domingo. There are no popular flight routes from Myrtle Beach to Santo Domingo.
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  • How far is Myrtle Beach Intl to Santo Domingo Las Americas by plane?

    A flight from Myrtle Beach Intl to Santo Domingo Las Americas will travel around 1186.3 mi. 17h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santo Domingo?

Best airlines flying from Myrtle Beach to Santo Domingo

Compare and see reviews for airlines that fly from Myrtle Beach to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $327Free CancellationRating
6.3
8,035 reviews
Search Spirit Airlines flights
DeltaPriceFrom $549Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Santo Domingo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santo Domingo from Myrtle Beach.

Can I find flights from Myrtle Beach to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Santo Domingo?

Once you have performed a search for Myrtle Beach to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Myrtle Beach to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Myrtle Beach to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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