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Cheap flights from Myrtle Beach to Santo Domingo from $121

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Santo Domingo departing on 4/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Myrtle Beach to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
6:28 pm - 1:38 am
MYR
-
SDQ
7h 10m
1 stop
Spirit Airlines Logo
2:52 am - 5:33 pm
SDQ
-
MYR
14h 41m
1 stop
$259Spirit Airlines
Wed, Mar 18 - Tue, Mar 24
Spirit Airlines Logo
6:28 pm - 1:38 am
MYR
-
SDQ
7h 10m
1 stop
Spirit Airlines Logo
2:52 am - 5:33 pm
SDQ
-
MYR
14h 41m
1 stop
$270Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
1:20 pm - 4:00 am
MYR
-
SDQ
13h 40m
1 stop
Spirit Airlines Logo
4:55 am - 3:04 pm
SDQ
-
MYR
11h 09m
1 stop
$298Spirit Airlines
Thu, Feb 26 - Fri, Feb 27
Spirit Airlines Logo
6:28 pm - 1:38 am
MYR
-
SDQ
7h 10m
1 stop
Spirit Airlines Logo
3:55 am - 8:48 pm
SDQ
-
MYR
16h 53m
1 stop
$305Spirit Airlines
Thu, Apr 9 - Sun, Apr 12
Spirit Airlines Logo
3:29 pm - 2:40 am
MYR
-
SDQ
11h 11m
1 stop
Spirit Airlines Logo
3:55 am - 8:48 pm
SDQ
-
MYR
16h 53m
1 stop
$324Spirit Airlines
Thu, Mar 12 - Sat, Mar 21
Spirit Airlines Logo
10:01 am - 1:15 pm
MYR
-
SDQ
27h 14m
2 stops
Spirit Airlines Logo
2:52 am - 5:33 pm
SDQ
-
MYR
14h 41m
1 stop
$328Spirit Airlines
Wed, Mar 18 - Tue, Mar 24
Spirit Airlines Logo
9:49 pm - 1:15 pm
MYR
-
SDQ
15h 26m
2 stops
Spirit Airlines Logo
2:52 am - 5:33 pm
SDQ
-
MYR
14h 41m
1 stop
$335Spirit Airlines
Sat, Mar 21 - Fri, Mar 27
Spirit Airlines Logo
1:20 pm - 4:00 am
MYR
-
SDQ
13h 40m
1 stop
Spirit Airlines Logo
2:32 pm - 8:13 am
SDQ
-
MYR
17h 41m
1 stop
$354Spirit Airlines
Fri, Mar 6 - Sun, Mar 8
Spirit Airlines Logo
6:28 pm - 1:38 am
MYR
-
SDQ
7h 10m
1 stop
Spirit Airlines Logo
2:20 pm - 11:05 am
SDQ
-
MYR
20h 45m
2 stops
$355Spirit Airlines
Thu, Apr 9 - Mon, Apr 13
Spirit Airlines Logo
10:01 am - 1:38 am
MYR
-
SDQ
15h 37m
3 stops
Spirit Airlines Logo
2:52 am - 5:33 pm
SDQ
-
MYR
14h 41m
1 stop
$361Spirit Airlines
Wed, Mar 18 - Tue, Mar 24

Spirit Airlines flights from Myrtle Beach to Santo Domingo

Our best Spirit Airlines deals on Myrtle Beach to Santo Domingo flight tickets
Spirit Airlines
Mar 18
MYR6:28 pmMyrtle Beach Intl
7h 10m
1 stop
SDQ1:38 amSanto Domingo Las Americas
Mar 24
SDQ2:52 amSanto Domingo Las Americas
14h 41m
1 stop
MYR5:33 pmMyrtle Beach Intl
$259
Spirit Airlines
Mar 21
MYR6:28 pmMyrtle Beach Intl
7h 10m
1 stop
SDQ1:38 amSanto Domingo Las Americas
Mar 27
SDQ2:52 amSanto Domingo Las Americas
14h 41m
1 stop
MYR5:33 pmMyrtle Beach Intl
$270
Spirit Airlines
Feb 26
MYR1:20 pmMyrtle Beach Intl
13h 40m
1 stop
SDQ4:00 amSanto Domingo Las Americas
Feb 27
SDQ4:55 amSanto Domingo Las Americas
11h 09m
1 stop
MYR3:04 pmMyrtle Beach Intl
$298

American Airlines flights from Myrtle Beach to Santo Domingo

Our best American Airlines deals on Myrtle Beach to Santo Domingo flight tickets
American Airlines
Mar 12
MYR3:18 pmMyrtle Beach Intl
17h 42m
2 stops
SDQ9:00 amSanto Domingo Las Americas
Mar 22
SDQ4:03 pmSanto Domingo Las Americas
18h 36m
2 stops
MYR10:39 amMyrtle Beach Intl
$533
American Airlines
Feb 21
MYR3:17 pmMyrtle Beach Intl
17h 43m
2 stops
SDQ10:00 amSanto Domingo Las Americas
Mar 7
SDQ5:07 pmSanto Domingo Las Americas
15h 25m
2 stops
MYR7:32 amMyrtle Beach Intl
$543
American Airlines
Feb 26
MYR6:23 pmMyrtle Beach Intl
14h 37m
2 stops
SDQ10:00 amSanto Domingo Las Americas
Feb 28
SDQ3:19 pmSanto Domingo Las Americas
18h 21m
2 stops
MYR8:40 amMyrtle Beach Intl
$563

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 3/18

6:28 pm-1:38 am

1 stop7h 10m

Santo Domingo Las Americas

Tue 3/24

2:52 am-5:33 pm

1 stop14h 41m

$259

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 3/21

6:28 pm-1:38 am

1 stop7h 10m

Santo Domingo Las Americas

Fri 3/27

2:52 am-5:33 pm

1 stop14h 41m

$270

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 2/26

1:20 pm-4:00 am

1 stop13h 40m

Santo Domingo Las Americas

Fri 2/27

4:55 am-3:04 pm

1 stop11h 09m

$298

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 4/9

6:28 pm-1:38 am

1 stop7h 10m

Santo Domingo Las Americas

Sun 4/12

3:55 am-8:48 pm

1 stop16h 53m

$305

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 3/12

3:29 pm-2:40 am

1 stop11h 11m

Santo Domingo Las Americas

Sat 3/21

3:55 am-8:48 pm

1 stop16h 53m

$324

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 3/18

10:01 am-1:15 pm

2 stops27h 14m

Santo Domingo Las Americas

Tue 3/24

2:52 am-5:33 pm

1 stop14h 41m

$328

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Sat 3/21

9:49 pm-1:15 pm

2 stops15h 26m

Santo Domingo Las Americas

Fri 3/27

2:52 am-5:33 pm

1 stop14h 41m

$335

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Fri 3/6

1:20 pm-4:00 am

1 stop13h 40m

Santo Domingo Las Americas

Sun 3/8

2:32 pm-8:13 am

1 stop17h 41m

$354

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Thu 4/9

6:28 pm-1:38 am

1 stop7h 10m

Santo Domingo Las Americas

Mon 4/13

2:20 pm-11:05 am

2 stops20h 45m

$355

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Wed 3/18

10:01 am-1:38 am

3 stops15h 37m

Santo Domingo Las Americas

Tue 3/24

2:52 am-5:33 pm

1 stop14h 41m

$361

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Myrtle Beach to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Myrtle Beach to Santo Domingo flights?

You could potentially save up to 26% on your flight if you consider stops on a Myrtle Beach to Santo Domingo flight.

When to book flights from Myrtle Beach to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Santo Domingo (MYR to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Santo Domingo

Fastest flight time

7h 17m

Direct flights

None
The fastest flight from Myrtle Beach to Santo Domingo takes 7h 17m
There are no direct flights from Myrtle Beach to Santo Domingo. There are no popular flight routes from Myrtle Beach to Santo Domingo.
Search flight deals

  • How far is Myrtle Beach Intl to Santo Domingo Las Americas by plane?

    A flight from Myrtle Beach Intl to Santo Domingo Las Americas will travel around 1186.3 mi. 7h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Myrtle Beach Intl Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The required travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santo Domingo Las Americas Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Myrtle Beach to Santo Domingo?

Best airlines flying from Myrtle Beach to Santo Domingo

Compare and see reviews for airlines that fly from Myrtle Beach to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $297Free CancellationRating
7.9
8,146 reviews
Search Delta flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Santo Domingo?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Santo Domingo from Myrtle Beach.

Can I find flights from Myrtle Beach to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Santo Domingo?

Once you have performed a search for Myrtle Beach to Santo Domingo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Myrtle Beach to Santo Domingo right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Myrtle Beach to Santo Domingo flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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