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Cheap flights from Myrtle Beach to Key West from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Key West departing on 12/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
3:29 pm - 9:46 pmMYR-EYW
6h 17m1 stop
American Airlines Logo
8:00 am - 1:59 pmEYW-MYR
5h 59m1 stop
$249American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
American Airlines Logo
3:29 pm - 11:07 pmMYR-EYW
7h 38m2 stops
American Airlines Logo
4:53 pm - 11:54 pmEYW-MYR
7h 01m1 stop
$254American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
American Airlines Logo
3:29 pm - 11:07 pmMYR-EYW
7h 38m2 stops
American Airlines Logo
4:20 pm - 11:54 pmEYW-MYR
7h 34m2 stops
$259American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
Multiple Airlines Logo
2:53 pm - 7:55 pmMYR-EYW
29h 02m1 stop
Multiple Airlines Logo
8:55 am - 7:28 pmEYW-MYR
10h 33m1 stop
$263Multiple Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
Delta Logo
2:35 pm - 8:06 pmMYR-EYW
5h 31m1 stop
Delta Logo
7:40 am - 1:50 pmEYW-MYR
6h 10m1 stop
$284Delta
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Wed, Oct 29 - Sun, Nov 2
Multiple Airlines Logo
2:14 pm - 9:02 amMYR-EYW
18h 48m1 stop
Multiple Airlines Logo
8:33 pm - 8:44 amEYW-MYR
12h 11m1 stop
$287Multiple Airlines
Find Deal
Fri, Oct 31 - Sun, Nov 2
American Airlines Logo
7:00 am - 5:16 pmMYR-EYW
10h 16m2 stops
American Airlines Logo
1:23 pm - 8:49 pmEYW-MYR
7h 26m1 stop
$289American Airlines
Find Deal
Thu, Oct 30 - Mon, Nov 3
Delta Logo
10:32 am - 5:15 pmMYR-EYW
6h 43m1 stop
Delta Logo
7:25 am - 12:31 pmEYW-MYR
5h 06m1 stop
$314Delta
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Sun, Dec 14 - Mon, Dec 22
Spirit Airlines Logo
9:59 am - 1:30 pmMYR-EYW
27h 31m3 stops
Spirit Airlines Logo
2:25 pm - 11:51 amEYW-MYR
21h 26m2 stops
$387Spirit Airlines
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Fri, Jan 23 - Wed, Jan 28
Spirit Airlines Logo
9:59 am - 1:30 pmMYR-EYW
27h 31m3 stops
Spirit Airlines Logo
2:25 pm - 11:51 amEYW-MYR
21h 26m3 stops
$434Spirit Airlines
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Fri, Jan 23 - Wed, Jan 28

American Airlines flights from Myrtle Beach to Key West

Our best American Airlines deals on Myrtle Beach to Key West flight tickets
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
6h 17m
1 stop
EYW9:46 pmKey West
Dec 13
EYW8:00 amKey West
5h 59m
1 stop
MYR1:59 pmMyrtle Beach Intl
$249
Find similar
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
7h 38m
2 stops
EYW11:07 pmKey West
Dec 13
EYW4:53 pmKey West
7h 01m
1 stop
MYR11:54 pmMyrtle Beach Intl
$254
Find similar
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
7h 38m
2 stops
EYW11:07 pmKey West
Dec 13
EYW4:20 pmKey West
7h 34m
2 stops
MYR11:54 pmMyrtle Beach Intl
$259
Find similar

Delta flights from Myrtle Beach to Key West

Our best Delta deals on Myrtle Beach to Key West flight tickets
Delta
Oct 29
MYR2:35 pmMyrtle Beach Intl
5h 31m
1 stop
EYW8:06 pmKey West
Nov 2
EYW7:40 amKey West
6h 10m
1 stop
MYR1:50 pmMyrtle Beach Intl
$284
Find similar
Delta
Dec 14
MYR10:32 amMyrtle Beach Intl
6h 43m
1 stop
EYW5:15 pmKey West
Dec 22
EYW7:25 amKey West
5h 06m
1 stop
MYR12:31 pmMyrtle Beach Intl
$314
Find similar
Delta
Dec 14
MYR2:40 pmMyrtle Beach Intl
5h 26m
1 stop
EYW8:06 pmKey West
Dec 21
EYW7:25 amKey West
5h 06m
1 stop
MYR12:31 pmMyrtle Beach Intl
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

8:00 am-1:59 pm

1 stop5h 59m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-11:07 pm

2 stops7h 38m

Key West

Sat 12/13

4:53 pm-11:54 pm

1 stop7h 01m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-11:07 pm

2 stops7h 38m

Key West

Sat 12/13

4:20 pm-11:54 pm

2 stops7h 34m

$259

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Thu 10/30

2:53 pm-7:55 pm

1 stop29h 02m

Key West

Mon 11/3

8:55 am-7:28 pm

1 stop10h 33m

$263

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 10/29

2:35 pm-8:06 pm

1 stop5h 31m

Key West

Sun 11/2

7:40 am-1:50 pm

1 stop6h 10m

$284

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 10/31

2:14 pm-9:02 am

1 stop18h 48m

Key West

Sun 11/2

8:33 pm-8:44 am

1 stop12h 11m

$287

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Thu 10/30

7:00 am-5:16 pm

2 stops10h 16m

Key West

Mon 11/3

1:23 pm-8:49 pm

1 stop7h 26m

$289

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 12/14

10:32 am-5:15 pm

1 stop6h 43m

Key West

Mon 12/22

7:25 am-12:31 pm

1 stop5h 06m

$314

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 1/23

9:59 am-1:30 pm

3 stops27h 31m

Key West

Wed 1/28

2:25 pm-11:51 am

2 stops21h 26m

$387

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 1/23

9:59 am-1:30 pm

3 stops27h 31m

Key West

Wed 1/28

2:25 pm-11:51 am

3 stops21h 26m

$434

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Myrtle Beach to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, November is the cheapest month to fly from Myrtle Beach to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $362. If you are unable to visit Key West during the month of November, then departing from Myrtle Beach during the month September is also very affordable. Most momondo users find prices during this month for around $366.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Myrtle Beach is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $398. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Key West for around $603.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from Myrtle Beach to Key West in the afternoon for as low as $445. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $488. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Myrtle Beach when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $442 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Myrtle Beach for as low as $291 on momondo.

Can stopping save me money on Myrtle Beach to Key West flights?

You could potentially save up to 23% on your flight if you consider stops on a Myrtle Beach to Key West flight.

When to book flights from Myrtle Beach to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Key West (MYR to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Key West

Direct flights

None
There are no direct flights from Myrtle Beach to Key West. There are no popular flight routes from Myrtle Beach to Key West.
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  • How far is Myrtle Beach Intl to Key West by plane?

    A flight from Myrtle Beach Intl to Key West will travel around 654.6 mi. Typically, this will take 4h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Key West Airport?

    Prices for flights from Myrtle Beach Intl Airport to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Key West Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Key West Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Key West?

Best airlines flying from Myrtle Beach to Key West

Compare and see reviews for airlines that fly from Myrtle Beach to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
7,984 reviews
Search Delta flights
American AirlinesPriceFrom $279Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Key West?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to Key West for you.

Can I find flights from Myrtle Beach to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Key West?

Once all potential Myrtle Beach to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Key West right now. Can momondo alert me if prices change?

Price alerts on flights to Key West from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Key West trip

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