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Cheap flights from Myrtle Beach to Key West from $224

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Key West departing on 10/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Myrtle Beach to Key West

Cheap round-trip flights

American Airlines Logo
12:12 pm - 5:46 pmMYR-EYW
5h 34m1 stop
American Airlines Logo
3:45 pm - 11:10 pmEYW-MYR
7h 25m1 stop
$229American Airlines
Find Deal
Fri, Sep 5 - Tue, Sep 9
American Airlines Logo
12:12 pm - 5:46 pmMYR-EYW
5h 34m1 stop
American Airlines Logo
11:25 am - 9:09 pmEYW-MYR
9h 44m2 stops
$234American Airlines
Find Deal
Fri, Sep 5 - Tue, Sep 9
American Airlines Logo
12:06 pm - 5:51 pmMYR-EYW
5h 45m1 stop
American Airlines Logo
7:31 am - 2:46 pmEYW-MYR
7h 15m1 stop
$249American Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
Delta Logo
6:00 am - 11:27 amMYR-EYW
5h 27m1 stop
Delta Logo
6:00 pm - 11:36 pmEYW-MYR
5h 36m1 stop
$251Delta
Find Deal
Tue, Oct 14 - Wed, Nov 12
American Airlines Logo
6:23 am - 1:05 pmMYR-EYW
6h 42m1 stop
American Airlines Logo
1:45 pm - 10:36 pmEYW-MYR
8h 51m2 stops
$254American Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
American Airlines Logo
10:07 am - 7:29 pmMYR-EYW
9h 22m2 stops
American Airlines Logo
1:45 pm - 8:49 pmEYW-MYR
7h 04m2 stops
$259American Airlines
Find Deal
Tue, Nov 11 - Tue, Nov 18
Delta Logo
4:00 pm - 8:12 pmMYR-EYW
4h 12m1 stop
Delta Logo
6:20 pm - 11:49 pmEYW-MYR
5h 29m1 stop
$298Delta
Find Deal
Sat, Sep 6 - Sun, Sep 7
Logo
1:43 pm - 5:46 pmMYR-EYW
28h 03m1 stop
Logo
2:25 pm - 10:41 amEYW-MYR
20h 16m1 stop
$303
Find Deal
Sun, Oct 19 - Mon, Nov 10
Logo
1:43 pm - 5:46 pmMYR-EYW
28h 03m1 stop
Logo
2:25 pm - 10:41 amEYW-MYR
20h 16m1 stop
$304
Find Deal
Sun, Oct 19 - Thu, Nov 6
Allegiant Air Logo
8:31 pm - 9:16 amMYR-EYW
12h 45m1 stop
Allegiant Air Logo
3:30 pm - 10:34 amEYW-MYR
19h 04m2 stops
$451Allegiant Air
Find Deal
Thu, Oct 16 - Sun, Oct 19

American Airlines flights from Myrtle Beach to Key West

Our best American Airlines deals on Myrtle Beach to Key West flight tickets
American Airlines
Sep 5
MYR12:12 pmMyrtle Beach Intl
5h 34m
1 stop
EYW5:46 pmKey West
Sep 9
EYW3:45 pmKey West
7h 25m
1 stop
MYR11:10 pmMyrtle Beach Intl
$229
Find similar
American Airlines
Sep 5
MYR12:12 pmMyrtle Beach Intl
5h 34m
1 stop
EYW5:46 pmKey West
Sep 9
EYW11:25 amKey West
9h 44m
2 stops
MYR9:09 pmMyrtle Beach Intl
$234
Find similar
American Airlines
Nov 11
MYR12:06 pmMyrtle Beach Intl
5h 45m
1 stop
EYW5:51 pmKey West
Nov 18
EYW7:31 amKey West
7h 15m
1 stop
MYR2:46 pmMyrtle Beach Intl
$249
Find similar

Delta flights from Myrtle Beach to Key West

Our best Delta deals on Myrtle Beach to Key West flight tickets
Delta
Oct 14
MYR6:00 amMyrtle Beach Intl
5h 27m
1 stop
EYW11:27 amKey West
Nov 12
EYW6:00 pmKey West
5h 36m
1 stop
MYR11:36 pmMyrtle Beach Intl
$251
Find similar
Delta
Aug 27
MYR2:20 pmMyrtle Beach Intl
5h 52m
1 stop
EYW8:12 pmKey West
Sep 3
EYW6:20 pmKey West
5h 29m
1 stop
MYR11:49 pmMyrtle Beach Intl
$284
Find similar
Delta
Sep 6
MYR4:00 pmMyrtle Beach Intl
4h 12m
1 stop
EYW8:12 pmKey West
Sep 7
EYW6:20 pmKey West
5h 29m
1 stop
MYR11:49 pmMyrtle Beach Intl
$298
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 9/5

12:12 pm-5:46 pm

1 stop5h 34m

Key West

Tue 9/9

3:45 pm-11:10 pm

1 stop7h 25m

$229

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 9/5

12:12 pm-5:46 pm

1 stop5h 34m

Key West

Tue 9/9

11:25 am-9:09 pm

2 stops9h 44m

$234

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 11/11

12:06 pm-5:51 pm

1 stop5h 45m

Key West

Tue 11/18

7:31 am-2:46 pm

1 stop7h 15m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 10/14

6:00 am-11:27 am

1 stop5h 27m

Key West

Wed 11/12

6:00 pm-11:36 pm

1 stop5h 36m

$251

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 11/11

6:23 am-1:05 pm

1 stop6h 42m

Key West

Tue 11/18

1:45 pm-10:36 pm

2 stops8h 51m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 11/11

10:07 am-7:29 pm

2 stops9h 22m

Key West

Tue 11/18

1:45 pm-8:49 pm

2 stops7h 04m

$259

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 9/6

4:00 pm-8:12 pm

1 stop4h 12m

Key West

Sun 9/7

6:20 pm-11:49 pm

1 stop5h 29m

$298

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 10/19

1:43 pm-5:46 pm

1 stop28h 03m

Key West

Mon 11/10

2:25 pm-10:41 am

1 stop20h 16m

$303

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 10/19

1:43 pm-5:46 pm

1 stop28h 03m

Key West

Thu 11/6

2:25 pm-10:41 am

1 stop20h 16m

$304

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Thu 10/16

8:31 pm-9:16 am

1 stop12h 45m

Key West

Sun 10/19

3:30 pm-10:34 am

2 stops19h 04m

$451

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Myrtle Beach to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Key West?

What is the cheapest month to fly to Key West?

In general, August is the cheapest month to fly from Myrtle Beach to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $316. If you are unable to visit Key West during the month of August, then departing from Myrtle Beach during the month November is also very affordable. Most momondo users find prices during this month for around $365.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Myrtle Beach is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $398. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Key West for around $603.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from Myrtle Beach to Key West in the afternoon for as low as $445. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $488. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from Myrtle Beach when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $441 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from Myrtle Beach for as low as $333 on momondo.

When to book flights from Myrtle Beach to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Key West (MYR to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Key West

Direct flights

None
There are no direct flights from Myrtle Beach to Key West. There are no popular flight routes from Myrtle Beach to Key West.
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  • How far is Myrtle Beach Intl to Key West by plane?

    A flight from Myrtle Beach Intl to Key West will travel around 654.6 mi. Typically, this will take 4h 12m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Key West Airport?

    Prices for flights from Myrtle Beach Intl Airport to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Key West Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Key West Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Key West?

Best airlines flying from Myrtle Beach to Key West

Compare and see reviews for airlines that fly from Myrtle Beach to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $284Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Key West?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to Key West for you.

Can I find flights from Myrtle Beach to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Key West?

Once all potential Myrtle Beach to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Key West right now. Can momondo alert me if prices change?

Price alerts on flights to Key West from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Key West trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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