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Cheap flights from Myrtle Beach to Key West from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Key West departing on 12/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Multiple Airlines Logo
6:09 pm - 10:09 amMYR-EYW
16h 00m1 stop
Multiple Airlines Logo
2:25 pm - 7:20 pmEYW-MYR
4h 55m1 stop
$246Multiple Airlines
Find Deal
Fri, Jan 9 - Mon, Jan 12
American Airlines Logo
6:23 am - 1:03 pmMYR-EYW
6h 40m1 stop
American Airlines Logo
8:00 am - 1:59 pmEYW-MYR
5h 59m1 stop
$249American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
Multiple Airlines Logo
6:15 am - 8:15 amMYR-EYW
26h 00m1 stop
Multiple Airlines Logo
10:47 am - 8:49 amEYW-MYR
22h 02m1 stop
$250Multiple Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
6:23 am - 1:03 pmMYR-EYW
6h 40m1 stop
American Airlines Logo
7:00 am - 1:59 pmEYW-MYR
6h 59m2 stops
$254American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
Multiple Airlines Logo
6:09 pm - 10:09 amMYR-EYW
16h 00m1 stop
Multiple Airlines Logo
2:25 pm - 7:20 pmEYW-MYR
4h 55m1 stop
$256Multiple Airlines
Find Deal
Fri, Jan 16 - Fri, Jan 23
American Airlines Logo
3:29 pm - 11:07 pmMYR-EYW
7h 38m2 stops
American Airlines Logo
7:00 am - 1:59 pmEYW-MYR
6h 59m2 stops
$259American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
Multiple Airlines Logo
8:59 pm - 3:04 pmMYR-EYW
42h 05m2 stops
Multiple Airlines Logo
4:31 pm - 8:49 amEYW-MYR
16h 18m1 stop
$261Multiple Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
5:29 pm - 9:47 pmMYR-EYW
4h 18m1 stop
American Airlines Logo
6:53 pm - 11:38 pmEYW-MYR
4h 45m1 stop
$264American Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
6:00 am - 4:44 pmMYR-EYW
10h 44m2 stops
American Airlines Logo
6:53 pm - 11:38 pmEYW-MYR
4h 45m1 stop
$269American Airlines
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Mon, Jan 5 - Sat, Jan 10
Spirit Airlines Logo
7:57 pm - 1:30 pmMYR-EYW
17h 33m1 stop
Spirit Airlines Logo
2:25 pm - 2:34 pmEYW-MYR
24h 09m2 stops
$278Spirit Airlines
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Sun, Feb 1 - Fri, Feb 6

American Airlines flights from Myrtle Beach to Key West

Our best American Airlines deals on Myrtle Beach to Key West flight tickets
American Airlines
Dec 8
MYR6:23 amMyrtle Beach Intl
6h 40m
1 stop
EYW1:03 pmKey West
Dec 13
EYW8:00 amKey West
5h 59m
1 stop
MYR1:59 pmMyrtle Beach Intl
$249
Find similar
American Airlines
Dec 8
MYR6:23 amMyrtle Beach Intl
6h 40m
1 stop
EYW1:03 pmKey West
Dec 13
EYW7:00 amKey West
6h 59m
2 stops
MYR1:59 pmMyrtle Beach Intl
$254
Find similar
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
7h 38m
2 stops
EYW11:07 pmKey West
Dec 13
EYW7:00 amKey West
6h 59m
2 stops
MYR1:59 pmMyrtle Beach Intl
$259
Find similar

Delta flights from Myrtle Beach to Key West

Our best Delta deals on Myrtle Beach to Key West flight tickets
Delta
Feb 16
MYR6:00 amMyrtle Beach Intl
5h 01m
1 stop
EYW11:01 amKey West
Feb 17
EYW6:07 pmKey West
5h 51m
1 stop
MYR11:58 pmMyrtle Beach Intl
$398
Find similar
Delta
Feb 11
MYR10:33 amMyrtle Beach Intl
6h 40m
1 stop
EYW5:13 pmKey West
Feb 17
EYW6:07 pmKey West
5h 51m
1 stop
MYR11:58 pmMyrtle Beach Intl
$408
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momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 1/9

6:09 pm-10:09 am

1 stop16h 00m

Key West

Mon 1/12

2:25 pm-7:20 pm

1 stop4h 55m

$246

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

6:23 am-1:03 pm

1 stop6h 40m

Key West

Sat 12/13

8:00 am-1:59 pm

1 stop5h 59m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 12/3

6:15 am-8:15 am

1 stop26h 00m

Key West

Wed 12/10

10:47 am-8:49 am

1 stop22h 02m

$250

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

6:23 am-1:03 pm

1 stop6h 40m

Key West

Sat 12/13

7:00 am-1:59 pm

2 stops6h 59m

$254

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 1/16

6:09 pm-10:09 am

1 stop16h 00m

Key West

Fri 1/23

2:25 pm-7:20 pm

1 stop4h 55m

$256

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-11:07 pm

2 stops7h 38m

Key West

Sat 12/13

7:00 am-1:59 pm

2 stops6h 59m

$259

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 12/3

8:59 pm-3:04 pm

2 stops42h 05m

Key West

Wed 12/10

4:31 pm-8:49 am

1 stop16h 18m

$261

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sat 1/17

5:29 pm-9:47 pm

1 stop4h 18m

Key West

Sat 1/24

6:53 pm-11:38 pm

1 stop4h 45m

$264

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 1/5

6:00 am-4:44 pm

2 stops10h 44m

Key West

Sat 1/10

6:53 pm-11:38 pm

1 stop4h 45m

$269

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Sun 2/1

7:57 pm-1:30 pm

1 stop17h 33m

Key West

Fri 2/6

2:25 pm-2:34 pm

2 stops24h 09m

$278

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Myrtle Beach to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from Myrtle Beach to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $366. If you are unable to visit Key West during the month of September, then departing from Myrtle Beach during the month August is also very affordable. Most momondo users find prices during this month for around $367.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from Myrtle Beach is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $398. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Key West for around $603.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from Myrtle Beach to Key West in the afternoon for as low as $445. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly in the morning, with an average ticket price of $488. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Myrtle Beach to Key West flights?

You could potentially save up to 23% on your flight if you consider stops on a Myrtle Beach to Key West flight.

When to book flights from Myrtle Beach to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Key West (MYR to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Key West

Direct flights

None
There are no direct flights from Myrtle Beach to Key West. There are no popular flight routes from Myrtle Beach to Key West.
Search flight deals

  • How far is Myrtle Beach Intl to Key West by plane?

    A flight from Myrtle Beach Intl to Key West will travel around 654.6 mi. Typically, this will take 4h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Key West Airport?

    Prices for flights from Myrtle Beach Intl Airport to Key West Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Key West Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Key West Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Myrtle Beach Intl Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The travel and health documents you'll need for your trip to Key West Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Key West Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Myrtle Beach to Key West?

Best airlines flying from Myrtle Beach to Key West

Compare and see reviews for airlines that fly from Myrtle Beach to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $279Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Key West?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Myrtle Beach to Key West for you.

Can I find flights from Myrtle Beach to Key West with flexible booking policies on momondo?

momondo does allow users to show only those flights to Key West from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Key West?

Once all potential Myrtle Beach to Key West flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Key West right now. Can momondo alert me if prices change?

Price alerts on flights to Key West from Myrtle Beach are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Key West trip

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