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Cheap flights from Myrtle Beach to Florida Keys from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Florida Keys departing on 10/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Spirit Airlines Logo
12:11 pm - 6:07 pmMYR-MIA
5h 56m1 stop
Spirit Airlines Logo
9:49 am - 8:55 pmMIA-MYR
11h 06m1 stop
$153Spirit Airlines
Find Deal
Wed, Oct 22 - Wed, Oct 29
Spirit Airlines Logo
12:06 pm - 6:07 pmMYR-MIA
6h 01m1 stop
Spirit Airlines Logo
8:24 pm - 10:04 pmMIA-MYR
1h 40mnonstop
$163Spirit Airlines
Find Deal
Tue, Oct 21 - Mon, Oct 27
Multiple Airlines Logo
8:14 am - 11:10 pmMYR-MIA
14h 56m1 stop
Multiple Airlines Logo
6:00 am - 3:04 pmMIA-MYR
9h 04m1 stop
$221Multiple Airlines
Find Deal
Wed, Oct 15 - Sun, Oct 19
Multiple Airlines Logo
3:59 pm - 9:50 pmMYR-MIA
5h 51m1 stop
Multiple Airlines Logo
6:00 am - 10:41 amMIA-MYR
28h 41m2 stops
$226Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
Delta Logo
6:58 pm - 12:29 amMYR-MIA
5h 31m1 stop
Delta Logo
8:05 am - 1:56 pmMIA-MYR
5h 51m1 stop
$239Delta
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Wed, Nov 5 - Tue, Nov 18
American Airlines Logo
12:05 pm - 6:01 pmMYR-EYW
5h 56m1 stop
American Airlines Logo
7:08 am - 1:23 pmEYW-MYR
6h 15m1 stop
$249American Airlines
Find Deal
Tue, Jan 6 - Tue, Jan 13
American Airlines Logo
3:29 pm - 9:46 pmMYR-EYW
6h 17m1 stop
American Airlines Logo
1:57 pm - 11:54 pmEYW-MYR
9h 57m2 stops
$254American Airlines
Find Deal
Mon, Dec 8 - Sat, Dec 13
Southwest Logo
8:00 am - 4:10 pmMYR-MIA
8h 10m1 stop
Southwest Logo
6:55 am - 2:15 pmMIA-MYR
7h 20m2 stops
$274Southwest
Find Deal
Wed, Nov 5 - Tue, Nov 18
Southwest Logo
8:25 am - 8:35 pmMYR-MIA
12h 10m2 stops
Southwest Logo
7:55 am - 7:45 pmMIA-MYR
11h 50m2 stops
$297Southwest
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Wed, Oct 22 - Wed, Oct 29
Delta Logo
2:15 pm - 7:44 pmMYR-EYW
5h 29m1 stop
Delta Logo
6:00 pm - 11:35 pmEYW-MYR
5h 35m1 stop
$344Delta
Find Deal
Fri, Feb 20 - Tue, Feb 24

American Airlines flights from Myrtle Beach to Florida Keys

Our best American Airlines deals on Myrtle Beach to Florida Keys flight tickets
American Airlines
Jan 6
MYR12:05 pmMyrtle Beach Intl
5h 56m
1 stop
EYW6:01 pmKey West
Jan 13
EYW7:08 amKey West
6h 15m
1 stop
MYR1:23 pmMyrtle Beach Intl
$249
Find similar
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
6h 17m
1 stop
EYW9:46 pmKey West
Dec 13
EYW1:57 pmKey West
9h 57m
2 stops
MYR11:54 pmMyrtle Beach Intl
$254
Find similar
American Airlines
Nov 5
MYR3:32 pmMyrtle Beach Intl
6h 36m
1 stop
MIA10:08 pmMiami
Nov 10
MIA7:01 amMiami
6h 22m
1 stop
MYR1:23 pmMyrtle Beach Intl
$255
Find similar

Spirit Airlines flights from Myrtle Beach to Florida Keys

Our best Spirit Airlines deals on Myrtle Beach to Florida Keys flight tickets
Spirit Airlines
Oct 22
MYR12:11 pmMyrtle Beach Intl
5h 56m
1 stop
MIA6:07 pmMiami
Oct 29
MIA9:49 amMiami
11h 06m
1 stop
MYR8:55 pmMyrtle Beach Intl
$153
Find similar
Spirit Airlines
Oct 8
MYR12:11 pmMyrtle Beach Intl
5h 56m
1 stop
MIA6:07 pmMiami
Oct 27
MIA8:24 pmMiami
1h 40m
MYR10:04 pmMyrtle Beach Intl
$156
Find similar
Spirit Airlines
Oct 21
MYR12:06 pmMyrtle Beach Intl
6h 01m
1 stop
MIA6:07 pmMiami
Oct 27
MIA8:24 pmMiami
1h 40m
MYR10:04 pmMyrtle Beach Intl
$163
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 2, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 10/22

12:11 pm-6:07 pm

1 stop5h 56m

Miami

Wed 10/29

9:49 am-8:55 pm

1 stop11h 06m

$153

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Tue 10/21

12:06 pm-6:07 pm

1 stop6h 01m

Miami

Mon 10/27

8:24 pm-10:04 pm

Nonstop1h 40m

$163

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 10/15

8:14 am-11:10 pm

1 stop14h 56m

Miami

Sun 10/19

6:00 am-3:04 pm

1 stop9h 04m

$221

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Thu 12/4

3:59 pm-9:50 pm

1 stop5h 51m

Miami

Mon 12/8

6:00 am-10:41 am

2 stops28h 41m

$226

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 11/5

6:58 pm-12:29 am

1 stop5h 31m

Miami

Tue 11/18

8:05 am-1:56 pm

1 stop5h 51m

$239

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Tue 1/6

12:05 pm-6:01 pm

1 stop5h 56m

Key West

Tue 1/13

7:08 am-1:23 pm

1 stop6h 15m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

1:57 pm-11:54 pm

2 stops9h 57m

$254

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 11/5

8:00 am-4:10 pm

1 stop8h 10m

Miami

Tue 11/18

6:55 am-2:15 pm

2 stops7h 20m

$274

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

Wed 10/22

8:25 am-8:35 pm

2 stops12h 10m

Miami

Wed 10/29

7:55 am-7:45 pm

2 stops11h 50m

$297

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Fri 2/20

2:15 pm-7:44 pm

1 stop5h 29m

Key West

Tue 2/24

6:00 pm-11:35 pm

1 stop5h 35m

$344

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from Myrtle Beach to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of August is another great option to travel to Florida Keys, with average flight prices from Myrtle Beach averaging around $312.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Myrtle Beach to Florida Keys is on a Monday when prices can be found for as low as $162. The most expensive day to fly to Florida Keys is Friday, with ticket prices averaging around $293.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is at noon. momondo users have found flights departing from Myrtle Beach to Florida Keys at noon for as low as $194. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the afternoon are often more expensive with an average ticket price of $357.

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Myrtle Beach when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $361 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Myrtle Beach for as low as $191 on momondo.

Can stopping save me money on Myrtle Beach to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Myrtle Beach to Florida Keys.

Cheap Myrtle Beach to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Florida Keys

Direct flights

None
There are no direct flights from Myrtle Beach to Florida Keys. There are no popular flight routes from Myrtle Beach to Florida Keys.
Search flight deals

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Florida Keys?

    Prices for flights from Myrtle Beach Intl Airport to Florida Keys are updated daily.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Florida Keys?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Florida Keys?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The travel and health documents you'll need for your trip to Florida Keys may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florida Keys. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Myrtle Beach to Florida Keys?

Best airlines flying from Myrtle Beach to Florida Keys

Compare and see reviews for airlines that fly from Myrtle Beach to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
7,962 reviews
Search Delta flights
American AirlinesPriceFrom $283Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Florida Keys?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florida Keys from Myrtle Beach.

Can I find flights from Myrtle Beach to Florida Keys with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florida Keys from Myrtle Beach with this policy.

How can momondo help me find flights from Myrtle Beach to Florida Keys?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Myrtle Beach to Florida Keys.

I’m not ready to book a flight from Myrtle Beach to Florida Keys right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Myrtle Beach to Florida Keys flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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