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Cheap flights from Missouri to Roanoke from $255

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Roanoke departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:20 pm - 12:27 amSTL  Lambert-St Louis-ROA Roanoke
4h 07m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 9:09 amROA  Roanoke-STL Lambert-St Louis
4h 09m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Oct 8 - Sun, Oct 11
American Airlines Logo
10:21 am - 4:41 pmSTL  Lambert-St Louis-ROA Roanoke
5h 20m1 stop Charlotte Douglas
American Airlines Logo
5:07 pm - 10:42 pmROA  Roanoke-STL Lambert-St Louis
6h 35m1 stop Charlotte Douglas
$319American Airlines
Wed, Sep 16 - Tue, Sep 22
Delta Logo
2:26 pm - 9:51 pmMCI  Kansas City-ROA Roanoke
6h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 9:22 amROA  Roanoke-MCI Kansas City
4h 22m1 stop Atlanta Hartsfield-Jackson
$319Delta
Tue, Sep 8 - Tue, Sep 15
Delta Logo
4:23 pm - 12:27 amMCI  Kansas City-ROA Roanoke
7h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 9:29 amROA  Roanoke-MCI Kansas City
4h 29m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Oct 8 - Sun, Oct 11
American Airlines Logo
7:44 am - 1:26 pmMCI  Kansas City-ROA Roanoke
4h 42m1 stop Charlotte Douglas
American Airlines Logo
6:20 am - 10:04 amROA  Roanoke-MCI Kansas City
4h 44m1 stop Charlotte Douglas
$319American Airlines
Thu, Sep 10 - Thu, Sep 17
American Airlines Logo
7:22 am - 1:48 pmMCI  Kansas City-ROA Roanoke
5h 26m1 stop Philadelphia
American Airlines Logo
4:49 pm - 11:17 pmROA  Roanoke-MCI Kansas City
7h 28m1 stop Chicago O'Hare Intl
$319American Airlines
Thu, Oct 8 - Sun, Oct 11
Delta Logo
6:44 pm - 12:27 amMCI  Kansas City-ROA Roanoke
4h 43m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 9:29 amROA  Roanoke-MCI Kansas City
4h 29m1 stop Atlanta Hartsfield-Jackson
$319Delta
Thu, Oct 8 - Sun, Oct 11
United Airlines Logo
10:55 am - 5:09 pmCOU  Columbia Regional-ROA Roanoke
5h 14m1 stop Chicago O'Hare Intl
United Airlines Logo
10:38 am - 2:30 pmROA  Roanoke-COU Columbia Regional
4h 52m1 stop Chicago O'Hare Intl
$338United Airlines
Sat, Aug 29 - Wed, Sep 2
United Airlines Logo
10:55 am - 5:09 pmCOU  Columbia Regional-ROA Roanoke
5h 14m1 stop Chicago O'Hare Intl
United Airlines Logo
6:40 am - 10:16 amROA  Roanoke-COU Columbia Regional
4h 36m1 stop Chicago O'Hare Intl
$388United Airlines
Sat, Sep 5 - Sun, Sep 6
United Airlines Logo
3:00 pm - 9:01 pmCOU  Columbia Regional-ROA Roanoke
5h 01m1 stop Chicago O'Hare Intl
United Airlines Logo
10:30 am - 2:18 pmROA  Roanoke-COU Columbia Regional
4h 48m1 stop Chicago O'Hare Intl
$388United Airlines
Sat, Nov 14 - Tue, Nov 17

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American Airlines flights from Missouri to Roanoke

Our best American Airlines deals on Missouri to Roanoke flight tickets
American Airlines
Sep 16
STL10:21 amLambert-St Louis
5h 20m
1 stop
ROA4:41 pmRoanoke
Sep 22
ROA5:07 pmRoanoke
6h 35m
1 stop
STL10:42 pmLambert-St Louis
$319
American Airlines
Aug 29
COU8:09 amColumbia Regional
4h 44m
1 stop
ROA1:53 pmRoanoke
Sep 2
ROA12:33 pmRoanoke
6h 30m
2 stops
COU6:03 pmColumbia Regional
$344
American Airlines
Aug 29
COU12:58 pmColumbia Regional
8h 51m
2 stops
ROA10:49 pmRoanoke
Sep 2
ROA10:35 amRoanoke
8h 28m
2 stops
COU6:03 pmColumbia Regional
$349

Delta flights from Missouri to Roanoke

Our best Delta deals on Missouri to Roanoke flight tickets
Delta
Oct 8
MCI4:23 pmKansas City
7h 04m
1 stop
ROA12:27 amRoanoke
Oct 11
ROA6:00 amRoanoke
4h 29m
1 stop
MCI9:29 amKansas City
$319
Delta
Sep 6
STL3:44 pmLambert-St Louis
4h 59m
1 stop
ROA9:43 pmRoanoke
Sep 7
ROA6:00 amRoanoke
4h 20m
1 stop
STL9:20 amLambert-St Louis
$334
Delta
Sep 6
STL6:00 amLambert-St Louis
11h 30m
2 stops
ROA6:30 pmRoanoke
Sep 7
ROA6:00 amRoanoke
4h 20m
1 stop
STL9:20 amLambert-St Louis
$547

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Missouri to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisRoanoke

STL Lambert-St Louis - ROA Roanoke

STLROA

Lambert-St Louis

Thu 10/8

7:20 pm-12:27 am

1 stop4h 07m

Roanoke

Sun 10/11

6:00 am-9:09 am

1 stop4h 09m

$319

St. LouisRoanoke

STL Lambert-St Louis - ROA Roanoke

STLROA

Lambert-St Louis

Wed 9/16

10:21 am-4:41 pm

1 stop5h 20m

Roanoke

Tue 9/22

5:07 pm-10:42 pm

1 stop6h 35m

$319

Kansas CityRoanoke

MCI Kansas City - ROA Roanoke

MCIROA

Kansas City

Tue 9/8

2:26 pm-9:51 pm

1 stop6h 25m

Roanoke

Tue 9/15

6:00 am-9:22 am

1 stop4h 22m

$319

Kansas CityRoanoke

MCI Kansas City - ROA Roanoke

MCIROA

Kansas City

Thu 10/8

4:23 pm-12:27 am

1 stop7h 04m

Roanoke

Sun 10/11

6:00 am-9:29 am

1 stop4h 29m

$319

Kansas CityRoanoke

MCI Kansas City - ROA Roanoke

MCIROA

Kansas City

Thu 9/10

7:44 am-1:26 pm

1 stop4h 42m

Roanoke

Thu 9/17

6:20 am-10:04 am

1 stop4h 44m

$319

Kansas CityRoanoke

MCI Kansas City - ROA Roanoke

MCIROA

Kansas City

Thu 10/8

7:22 am-1:48 pm

1 stop5h 26m

Roanoke

Sun 10/11

4:49 pm-11:17 pm

1 stop7h 28m

$319

Kansas CityRoanoke

MCI Kansas City - ROA Roanoke

MCIROA

Kansas City

Thu 10/8

6:44 pm-12:27 am

1 stop4h 43m

Roanoke

Sun 10/11

6:00 am-9:29 am

1 stop4h 29m

$319

ColumbiaRoanoke

COU Columbia Regional - ROA Roanoke

COUROA

Columbia Regional

Sat 8/29

10:55 am-5:09 pm

1 stop5h 14m

Roanoke

Wed 9/2

10:38 am-2:30 pm

1 stop4h 52m

$338

ColumbiaRoanoke

COU Columbia Regional - ROA Roanoke

COUROA

Columbia Regional

Sat 9/5

10:55 am-5:09 pm

1 stop5h 14m

Roanoke

Sun 9/6

6:40 am-10:16 am

1 stop4h 36m

$388

ColumbiaRoanoke

COU Columbia Regional - ROA Roanoke

COUROA

Columbia Regional

Sat 11/14

3:00 pm-9:01 pm

1 stop5h 01m

Roanoke

Tue 11/17

10:30 am-2:18 pm

1 stop4h 48m

$388

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from Missouri to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Roanoke?

The month of February is, on average, the cheapest month to fly to Roanoke from Missouri, with most prices found around $279. If you aren’t able to travel to Roanoke during the month of February, then flying in January is also cheap. Prices for this month can be found on momondo for an average of $279.

Cheap Missouri to Roanoke flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Roanoke

Fastest flight time

4h 07m

Direct flights

None
The fastest flight from Missouri to Roanoke takes 4h 07m
There are no direct flights from Missouri to Roanoke. There are no popular flight routes from Missouri to Roanoke.
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Frequently asked questions about flying from Missouri to Roanoke

  • When did momondo last update prices for flights from Missouri to Roanoke Airport?

    Prices for flights from Missouri to Roanoke Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Roanoke Airport?

  • How old do you have to be to fly from Missouri to Roanoke Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The required travel and health documents for your Roanoke Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Roanoke Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Missouri to Roanoke

Compare and see reviews for airlines that fly from Missouri to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,950 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.8
8,502 reviews
Search Delta flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
10,104 reviews
Search United Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Christiansburg
Salem
Radford
Rocky Mount
Lafayette

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Roanoke?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Missouri to Roanoke. momondo saves you time and could save you money on your trip.

Can I find flights from Missouri to Roanoke with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Roanoke from Missouri with this policy.

How can momondo help me find flights from Missouri to Roanoke?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Roanoke from Missouri.

I’m not ready to book a flight from Missouri to Roanoke right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Missouri to Roanoke now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Roanoke and let you know when they change.

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