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Cheap flights from Missouri to Panama City from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 8/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:59 pm - 11:04 pm
STL
-
ECP
4h 05m
1 stop
Delta Logo
4:31 pm - 9:19 pm
ECP
-
STL
4h 48m
1 stop
$197Delta
Fri, Apr 10 - Fri, Apr 17
Delta Logo
5:40 am - 12:38 pm
MCI
-
ECP
6h 58m
1 stop
Delta Logo
7:45 am - 12:21 pm
ECP
-
MCI
4h 36m
1 stop
$197Delta
Wed, Jul 15 - Thu, Jul 30
Delta Logo
5:06 pm - 10:39 pm
MCI
-
ECP
5h 33m
1 stop
Delta Logo
1:30 pm - 5:34 pm
ECP
-
MCI
4h 04m
1 stop
$201Delta
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
3:28 pm - 11:46 pm
MCI
-
ECP
8h 18m
2 stops
American Airlines Logo
1:24 pm - 10:49 pm
ECP
-
MCI
9h 25m
1 stop
$202American Airlines
Sat, Apr 25 - Wed, Apr 29
United Airlines Logo
4:28 pm - 9:56 pm
STL
-
ECP
5h 28m
1 stop
United Airlines Logo
5:00 pm - 10:14 pm
ECP
-
STL
5h 14m
1 stop
$205United Airlines
Mon, Feb 23 - Fri, Feb 27
Delta Logo
6:16 pm - 10:39 pm
MCI
-
ECP
4h 23m
1 stop
Delta Logo
4:04 pm - 9:58 pm
ECP
-
MCI
5h 54m
1 stop
$205Delta
Mon, Mar 2 - Fri, Mar 6
American Airlines Logo
2:19 pm - 11:49 pm
STL
-
ECP
9h 30m
2 stops
American Airlines Logo
1:18 pm - 9:37 pm
ECP
-
STL
8h 19m
1 stop
$210American Airlines
Mon, Feb 23 - Fri, Feb 27
American Airlines Logo
3:28 pm - 11:46 pm
MCI
-
ECP
8h 18m
2 stops
American Airlines Logo
1:24 pm - 10:49 pm
ECP
-
MCI
9h 25m
1 stop
$211American Airlines
Sat, Apr 25 - Wed, Apr 29
United Airlines Logo
6:00 am - 12:04 pm
SGF
-
ECP
6h 04m
1 stop
United Airlines Logo
2:10 pm - 9:59 pm
ECP
-
SGF
7h 49m
1 stop
$269United Airlines
Sun, Mar 1 - Sat, Mar 7
United Airlines Logo
2:53 pm - 9:56 pm
SGF
-
ECP
7h 03m
1 stop
United Airlines Logo
5:00 pm - 10:05 pm
ECP
-
SGF
5h 05m
1 stop
$279United Airlines
Sat, Feb 21 - Wed, Feb 25

United Airlines flights from Missouri to Panama City, Florida

Our best United Airlines deals on Missouri to Panama City, Florida flight tickets
United Airlines
Feb 23
STL4:28 pmLambert-St Louis
5h 28m
1 stop
ECP9:56 pmPanama City NW Florida Beaches
Feb 27
ECP5:00 pmPanama City NW Florida Beaches
5h 14m
1 stop
STL10:14 pmLambert-St Louis
$205
United Airlines
Mar 21
MCI6:05 amKansas City
5h 59m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
Mar 25
ECP5:03 pmPanama City NW Florida Beaches
5h 27m
1 stop
MCI10:30 pmKansas City
$237
United Airlines
Jun 30
MCI7:45 amKansas City
5h 44m
1 stop
ECP1:29 pmPanama City NW Florida Beaches
Jul 4
ECP6:30 amPanama City NW Florida Beaches
9h 37m
2 stops
MCI4:07 pmKansas City
$242

Delta flights from Missouri to Panama City, Florida

Our best Delta deals on Missouri to Panama City, Florida flight tickets
Delta
Jul 15
MCI5:40 amKansas City
6h 58m
1 stop
ECP12:38 pmPanama City NW Florida Beaches
Jul 28
ECP6:00 amPanama City NW Florida Beaches
6h 21m
1 stop
MCI12:21 pmKansas City
$197
Delta
Mar 7
MCI5:06 pmKansas City
5h 33m
1 stop
ECP10:39 pmPanama City NW Florida Beaches
Mar 11
ECP1:30 pmPanama City NW Florida Beaches
4h 04m
1 stop
MCI5:34 pmKansas City
$201
Delta
Feb 22
MCI5:06 pmKansas City
5h 33m
1 stop
ECP10:39 pmPanama City NW Florida Beaches
Feb 27
ECP8:03 amPanama City NW Florida Beaches
4h 13m
1 stop
MCI12:16 pmKansas City
$205

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Missouri to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 4/10

6:59 pm-11:04 pm

1 stop4h 05m

Panama City NW Florida Beaches

Fri 4/17

4:31 pm-9:19 pm

1 stop4h 48m

$197

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Wed 7/15

5:40 am-12:38 pm

1 stop6h 58m

Panama City NW Florida Beaches

Thu 7/30

7:45 am-12:21 pm

1 stop4h 36m

$197

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 3/7

5:06 pm-10:39 pm

1 stop5h 33m

Panama City NW Florida Beaches

Wed 3/11

1:30 pm-5:34 pm

1 stop4h 04m

$201

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/25

3:28 pm-11:46 pm

2 stops8h 18m

Panama City NW Florida Beaches

Wed 4/29

1:24 pm-10:49 pm

1 stop9h 25m

$202

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 2/23

4:28 pm-9:56 pm

1 stop5h 28m

Panama City NW Florida Beaches

Fri 2/27

5:00 pm-10:14 pm

1 stop5h 14m

$205

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Mon 3/2

6:16 pm-10:39 pm

1 stop4h 23m

Panama City NW Florida Beaches

Fri 3/6

4:04 pm-9:58 pm

1 stop5h 54m

$205

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 2/23

2:19 pm-11:49 pm

2 stops9h 30m

Panama City NW Florida Beaches

Fri 2/27

1:18 pm-9:37 pm

1 stop8h 19m

$210

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Sat 4/25

3:28 pm-11:46 pm

2 stops8h 18m

Panama City NW Florida Beaches

Wed 4/29

1:24 pm-10:49 pm

1 stop9h 25m

$211

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Sun 3/1

6:00 am-12:04 pm

1 stop6h 04m

Panama City NW Florida Beaches

Sat 3/7

2:10 pm-9:59 pm

1 stop7h 49m

$269

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Sat 2/21

2:53 pm-9:56 pm

1 stop7h 03m

Panama City NW Florida Beaches

Wed 2/25

5:00 pm-10:05 pm

1 stop5h 05m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Missouri to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Missouri is in October. Flight prices, which tend to average around $279, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Panama City, Florida, with average flight prices from Missouri averaging around $288.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $313. On the other hand, Friday is the most expensive day to depart from Missouri because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $524.

What is the cheapest Missouri to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Missouri - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $358 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Missouri for as low as $313 on momondo.

What cabin class options are available on Missouri to Panama City NW Florida Beaches flights?

There is only 1 cabin class available to choose from on Missouri to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Panama City, Florida flights?

You could potentially save up to 50% on your flight if you consider stops on a Missouri to Panama City, Florida flight.

Cheap Missouri to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City, Florida

Best Price Found

$377

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best flight deal from Missouri to Panama City, Florida found on momondo in the last 72 hours is $377
The fastest flight from Missouri to Panama City, Florida takes 1h 45m
Direct flights go from Missouri to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From Missouri there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

  • When did momondo last update prices for flights from Missouri to Panama City NW Florida Beaches Airport?

    Prices for flights from Missouri to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Missouri to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Panama City, Florida?

Best airlines flying from Missouri to Panama City, Florida

Compare and see reviews for airlines that fly from Missouri to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.9
8,173 reviews
Search Delta flights
American AirlinesPriceFrom $186Free CancellationRating
7.2
11,254 reviews
Search American Airlines flights
United AirlinesPriceFrom $226Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights
SouthwestPriceFrom $228Free CancellationRating
8.0
4,282 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

It is quick and easy to find Missouri to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Missouri to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Missouri to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Missouri. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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