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Cheap flights from Missouri to Panama City from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Panama City departing on 7/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Missouri to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:25 pm - 9:15 pm
STL
-
ECP
1h 50mnonstop
Southwest Logo
5:30 pm - 7:20 pm
ECP
-
STL
1h 50mnonstop
$297Southwest
Wed, Jul 22 - Wed, Jul 29
Southwest Logo
2:50 pm - 4:35 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
3:45 pm - 5:30 pm
ECP
-
STL
1h 45mnonstop
$303Southwest
Mon, Aug 17 - Wed, Aug 19
Delta Logo
7:05 am - 12:39 pm
STL
-
ECP
5h 34m
1 stop
Delta Logo
1:46 pm - 7:58 pm
ECP
-
STL
6h 12m
1 stop
$307Delta
Sat, Sep 26 - Wed, Sep 30
Southwest Logo
7:05 pm - 8:55 pm
STL
-
ECP
1h 50mnonstop
Southwest Logo
9:10 am - 5:55 pm
ECP
-
STL
8h 45m
2 stops
$312Southwest
Sat, Aug 1 - Tue, Aug 11
Southwest Logo
2:50 pm - 4:35 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
7:45 am - 1:55 pm
ECP
-
STL
6h 10m
1 stop
$313Southwest
Mon, Aug 17 - Wed, Aug 19
American Airlines Logo
3:01 pm - 10:40 pm
SGF
-
ECP
7h 39m
1 stop
American Airlines Logo
3:06 pm - 10:43 pm
ECP
-
SGF
7h 37m
1 stop
$318American Airlines
Tue, Aug 11 - Thu, Aug 20
Delta Logo
3:58 pm - 8:08 pm
MCI
-
ECP
4h 10m
1 stop
Delta Logo
7:35 am - 1:52 pm
ECP
-
MCI
6h 17m
1 stop
$319Delta
Thu, Aug 27 - Mon, Aug 31
Delta Logo
5:23 pm - 9:40 pm
STL
-
ECP
4h 17m
1 stop
Delta Logo
6:00 am - 9:54 am
ECP
-
STL
3h 54m
1 stop
$326Delta
Tue, Aug 4 - Mon, Aug 10
American Airlines Logo
9:31 am - 2:10 pm
SGF
-
ECP
4h 39m
1 stop
American Airlines Logo
7:10 am - 12:49 pm
ECP
-
SGF
5h 39m
1 stop
$345American Airlines
Wed, Aug 19 - Sun, Aug 30
American Airlines Logo
6:29 pm - 11:36 pm
SGF
-
ECP
5h 07m
1 stop
American Airlines Logo
1:32 pm - 8:42 pm
ECP
-
SGF
7h 10m
1 stop
$351American Airlines
Thu, Sep 17 - Tue, Sep 22

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Delta flights from Missouri to Panama City, Florida

Our best Delta deals on Missouri to Panama City, Florida flight tickets
Delta
Aug 27
MCI3:58 pmKansas City
4h 10m
1 stop
ECP8:08 pmPanama City NW Florida Beaches
Aug 31
ECP7:35 amPanama City NW Florida Beaches
6h 17m
1 stop
MCI1:52 pmKansas City
$319
Delta
Aug 4
STL5:23 pmLambert-St Louis
4h 17m
1 stop
ECP9:40 pmPanama City NW Florida Beaches
Aug 10
ECP6:00 amPanama City NW Florida Beaches
3h 54m
1 stop
STL9:54 amLambert-St Louis
$326
Delta
Jul 15
MCI1:18 pmKansas City
5h 32m
1 stop
ECP6:50 pmPanama City NW Florida Beaches
Jul 19
ECP6:48 pmPanama City NW Florida Beaches
5h 10m
1 stop
MCI11:58 pmKansas City
$334

Southwest flights from Missouri to Panama City, Florida

Our best Southwest deals on Missouri to Panama City, Florida flight tickets
Southwest
Jul 22
STL7:25 pmLambert-St Louis
1h 50m
ECP9:15 pmPanama City NW Florida Beaches
Jul 29
ECP5:30 pmPanama City NW Florida Beaches
1h 50m
STL7:20 pmLambert-St Louis
$297
Southwest
Aug 17
STL2:50 pmLambert-St Louis
1h 45m
ECP4:35 pmPanama City NW Florida Beaches
Aug 19
ECP3:45 pmPanama City NW Florida Beaches
1h 45m
STL5:30 pmLambert-St Louis
$303
Southwest
Jul 22
STL7:25 pmLambert-St Louis
1h 50m
ECP9:15 pmPanama City NW Florida Beaches
Jul 29
ECP7:00 amPanama City NW Florida Beaches
5h 05m
1 stop
STL12:05 pmLambert-St Louis
$307

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Missouri to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 7/22

7:25 pm-9:15 pm

Nonstop1h 50m

Panama City NW Florida Beaches

Wed 7/29

5:30 pm-7:20 pm

Nonstop1h 50m

$297
Quickest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/17

2:50 pm-4:35 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Wed 8/19

3:45 pm-5:30 pm

Nonstop1h 45m

$303

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 9/26

7:05 am-12:39 pm

1 stop5h 34m

Panama City NW Florida Beaches

Wed 9/30

1:46 pm-7:58 pm

1 stop6h 12m

$307

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 8/1

7:05 pm-8:55 pm

Nonstop1h 50m

Panama City NW Florida Beaches

Tue 8/11

9:10 am-5:55 pm

2 stops8h 45m

$312

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/17

2:50 pm-4:35 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Wed 8/19

7:45 am-1:55 pm

1 stop6h 10m

$313

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Tue 8/11

3:01 pm-10:40 pm

1 stop7h 39m

Panama City NW Florida Beaches

Thu 8/20

3:06 pm-10:43 pm

1 stop7h 37m

$318

Kansas CityPanama City

MCI - ECP

MCIECP

Kansas City

Thu 8/27

3:58 pm-8:08 pm

1 stop4h 10m

Panama City NW Florida Beaches

Mon 8/31

7:35 am-1:52 pm

1 stop6h 17m

$319

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/4

5:23 pm-9:40 pm

1 stop4h 17m

Panama City NW Florida Beaches

Mon 8/10

6:00 am-9:54 am

1 stop3h 54m

$326

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Wed 8/19

9:31 am-2:10 pm

1 stop4h 39m

Panama City NW Florida Beaches

Sun 8/30

7:10 am-12:49 pm

1 stop5h 39m

$345

SpringfieldPanama City

SGF - ECP

SGFECP

Springfield-Branson

Thu 9/17

6:29 pm-11:36 pm

1 stop5h 07m

Panama City NW Florida Beaches

Tue 9/22

1:32 pm-8:42 pm

1 stop7h 10m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Missouri to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Missouri is in February. Flight prices, which tend to average around $90, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from Missouri averaging around $102.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $364. On the other hand, Sunday is the most expensive day to depart from Missouri because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $525.

What is the cheapest Missouri to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Missouri - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight from Missouri to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $364 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Missouri for as low as $318 on momondo.

What cabin class options are available on Missouri to Panama City, Florida flights?

There is only 1 cabin class available to choose from on Missouri to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Panama City, Florida flights?

You could potentially save up to 8% on your flight if you consider stops on a Missouri to Panama City, Florida flight.

Cheap Missouri to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Panama City, Florida

Best Price Found

$233

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best one-way flight to Panama City, Florida from Missouri in the past 72 hours is $233. The best round-trip flight deal from Missouri to Panama City, Florida found on momondo in the last 72 hours is $373.
The fastest flight from Missouri to Panama City, Florida takes 1h 45m
Direct flights go from Missouri to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From Missouri there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from Missouri to Panama City, Florida

  • When did momondo last update prices for flights from Missouri to Panama City NW Florida Beaches Airport?

    Prices for flights from Missouri to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Missouri to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Panama City, Florida?

Best airlines flying from Missouri to Panama City, Florida

Compare and see reviews for airlines that fly from Missouri to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.8
8,451 reviews
Search Delta flights
American AirlinesPriceFrom $186Free CancellationRating
7.1
11,779 reviews
Search American Airlines flights
SouthwestPriceFrom $208Free CancellationRating
7.9
4,246 reviews
Search Southwest flights
United AirlinesPriceFrom $266Free CancellationRating
7.4
9,896 reviews
Search United Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Panama City?

It is quick and easy to find Missouri to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Missouri to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Missouri to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from Missouri to Panama City?

momondo provides multiple filters to help you find the best flight to Panama City from Missouri. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Missouri to Panama City right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Panama City from Missouri. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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