Cheap flights from Missouri to Panama City from $104

The cheapest month to fly to Panama City, Florida from Missouri is in February. Flight prices, which tend to average around $332, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Panama City, Florida, with average flight prices from Missouri averaging around $350.

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $362. On the other hand, Sunday is the most expensive day to depart from Missouri because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $549.

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Missouri - Panama City NW Florida Beaches flight prices

You are more likely to see cheaper flights to Panama City, Florida from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $368 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Missouri for as low as $338 on momondo.

There is only 1 cabin class available to choose from on Missouri to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 35% on your flight if you consider stops on a Missouri to Panama City, Florida flight.

Delta, Southwest, and United Airlines are the most popular carriers operating from Missouri to Panama City NW Florida Beaches

Allegiant Air, Southwest and Delta are the top three most popular airlines that fly to Panama City, Florida from Missouri according to our data. Allegiant Air is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 5 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

As of August 2026, 3 flights take off from Missouri and land in Panama City, Florida each week. The most common flight departure day for this route is Mon, with 33% of weekly flights taking off on this day.

Flight times vary depending on what airport in Missouri you fly out of and what airport in Panama City, Florida you fly into. For example, flying from St. Louis to Pensacola takes 1h 40m on average. On the other hand, flying from Kansas City to Pensacola takes 2h on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.