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Cheap flights from Minneapolis to Florence from $281

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Minneapolis to Florence departing on 3/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Minneapolis to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:02 pm - 11:08 pm
MSP
-
FLO
7h 06m
1 stop
American Airlines Logo
5:16 am - 9:26 am
FLO
-
MSP
5h 10m
1 stop
$385American Airlines
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
6:35 am - 5:21 pm
MSP
-
FLO
9h 46m
2 stops
American Airlines Logo
5:16 am - 9:26 am
FLO
-
MSP
5h 10m
1 stop
$390American Airlines
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
6:35 am - 5:21 pm
MSP
-
FLO
9h 46m
2 stops
American Airlines Logo
5:16 am - 3:46 pm
FLO
-
MSP
11h 30m
2 stops
$396American Airlines
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
3:02 pm - 11:08 pm
MSP
-
FLO
7h 06m
1 stop
American Airlines Logo
5:16 am - 9:26 am
FLO
-
MSP
5h 10m
1 stop
$405American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
6:35 am - 5:21 pm
MSP
-
FLO
9h 46m
2 stops
American Airlines Logo
5:16 am - 9:26 am
FLO
-
MSP
5h 10m
1 stop
$410American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
3:51 pm - 11:53 pm
MSP
-
FLO
7h 02m
1 stop
American Airlines Logo
4:16 pm - 11:59 pm
FLO
-
MSP
8h 43m
2 stops
$524American Airlines
Fri, May 8 - Mon, May 11
American Airlines Logo
6:35 am - 5:21 pm
MSP
-
FLO
9h 46m
2 stops
American Airlines Logo
5:16 am - 12:32 pm
FLO
-
MSP
8h 16m
2 stops
$546American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
6:00 am - 3:50 pm
MSP
-
FLO
8h 50m
2 stops
American Airlines Logo
4:16 pm - 11:59 pm
FLO
-
MSP
8h 43m
2 stops
$580American Airlines
Fri, May 8 - Mon, May 11
American Airlines Logo
3:51 pm - 11:53 pm
MSP
-
FLO
7h 02m
1 stop
American Airlines Logo
5:24 am - 9:48 am
FLO
-
MSP
5h 24m
1 stop
$647American Airlines
Fri, May 8 - Mon, May 11
American Airlines Logo
6:00 am - 10:43 pm
MSP
-
FLO
15h 43m
2 stops
American Airlines Logo
5:36 pm - 9:45 am
FLO
-
MSP
17h 09m
2 stops
$805American Airlines
Sun, Feb 1 - Thu, Feb 5

American Airlines flights from Minneapolis to Florence, South Carolina

Our best American Airlines deals on Minneapolis to Florence, South Carolina flight tickets
American Airlines
Jan 20
MSP4:47 pmMinneapolis St Paul
4h 56m
1 stop
FLO10:43 pmFlorence
Jan 27
FLO5:36 pmFlorence
4h 50m
1 stop
MSP9:26 pmMinneapolis St Paul
$383
American Airlines
Feb 25
MSP3:02 pmMinneapolis St Paul
7h 06m
1 stop
FLO11:08 pmFlorence
Feb 28
FLO5:16 amFlorence
5h 10m
1 stop
MSP9:26 amMinneapolis St Paul
$385
American Airlines
Jan 20
MSP10:54 amMinneapolis St Paul
5h 15m
1 stop
FLO5:09 pmFlorence
Jan 27
FLO6:15 amFlorence
11h 45m
2 stops
MSP5:00 pmMinneapolis St Paul
$388

momondo Fare Finder

 
Customize your flight search to find flights from Minneapolis to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 17, 2026.
Use the filters below to find and compare flights from Minneapolis to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

3:02 pm-11:08 pm

1 stop7h 06m

Florence

Sat 2/28

5:16 am-9:26 am

1 stop5h 10m

$385

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

6:35 am-5:21 pm

2 stops9h 46m

Florence

Sat 2/28

5:16 am-9:26 am

1 stop5h 10m

$390

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

6:35 am-5:21 pm

2 stops9h 46m

Florence

Sat 2/28

5:16 am-3:46 pm

2 stops11h 30m

$396

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

3:02 pm-11:08 pm

1 stop7h 06m

Florence

Sun 3/1

5:16 am-9:26 am

1 stop5h 10m

$405

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

6:35 am-5:21 pm

2 stops9h 46m

Florence

Sun 3/1

5:16 am-9:26 am

1 stop5h 10m

$410

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Fri 5/8

3:51 pm-11:53 pm

1 stop7h 02m

Florence

Mon 5/11

4:16 pm-11:59 pm

2 stops8h 43m

$524

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 2/25

6:35 am-5:21 pm

2 stops9h 46m

Florence

Sun 3/1

5:16 am-12:32 pm

2 stops8h 16m

$546

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Fri 5/8

6:00 am-3:50 pm

2 stops8h 50m

Florence

Mon 5/11

4:16 pm-11:59 pm

2 stops8h 43m

$580

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Fri 5/8

3:51 pm-11:53 pm

1 stop7h 02m

Florence

Mon 5/11

5:24 am-9:48 am

1 stop5h 24m

$647

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Sun 2/1

6:00 am-10:43 pm

2 stops15h 43m

Florence

Thu 2/5

5:36 pm-9:45 am

2 stops17h 09m

$805

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Minneapolis to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Minneapolis St Paul to Florence?

American Airlines is the most popular carrier operating from Minneapolis St Paul to Florence

What airlines fly to Florence, South Carolina?

Delta, American Airlines and Sun Country Air are the top three most popular airlines that fly to Florence, South Carolina from Minneapolis according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Minneapolis to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Minneapolis to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Minneapolis to Florence, South Carolina (MSP to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Minneapolis to Florence, South Carolina

Fastest flight time

4h 56m

Direct flights

None
The fastest flight from Minneapolis to Florence, South Carolina takes 4h 56m
There are no direct flights from Minneapolis to Florence, South Carolina. There are no popular flight routes from Minneapolis to Florence, South Carolina.
Search flight deals

  • How far is Minneapolis St Paul to Florence by plane?

    Minneapolis St Paul and Florence are 1032.0 mi apart from one another. Flights usually cover this in 4h 56m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Minneapolis St Paul Airport to Florence Airport?

    Prices for flights from Minneapolis St Paul Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Minneapolis St Paul Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Minneapolis St Paul Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Minneapolis to Florence?

It is quick and easy to find Minneapolis to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Minneapolis to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Minneapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Minneapolis to Florence?

Once all potential Minneapolis to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Minneapolis to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Minneapolis. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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