What is the cheapest airline that flies from Chicago Midway to Greenville?

Delta and Southwest are the most popular carriers operating from Chicago Midway to Greenville

What airlines fly to Greenville?

Southwest, Delta and Allegiant Air are the top three most popular airlines that fly to Greenville from Chicago Midway Airport according to our data. Southwest is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Chicago Midway Airport to Greenville Airport?

Prices for flights from Chicago Midway Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Chicago Midway Airport to Greenville Airport?

As of December 2025, there is 1 operator available to choose from for flights from Chicago Midway Airport to Greenville Airport.

How old do you have to be to fly from Chicago Midway Airport to Greenville Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago Midway Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$108 Cheap Flights from Chicago Midway Airport to Greenville in 2025/26

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Find the cheapest flights from Chicago Midway Airport to Greenville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:14 pm - 11:50 pm

MDW

GSP

4h 36m1 stop

5:40 am - 9:53 am

GSP

MDW

5h 13m1 stop

$215Delta

Wed, Jan 21 - Wed, Jan 28

6:30 am - 2:05 pm

MDW

GSP

6h 35m1 stop

5:40 pm - 10:29 pm

GSP

MDW

5h 49m1 stop

$222Delta

Tue, Apr 14 - Sun, Apr 19

6:14 pm - 11:50 pm

MDW

GSP

4h 36m1 stop

5:12 pm - 10:22 pm

GSP

MDW

6h 10m1 stop

$229Delta

Fri, Jan 23 - Mon, Jan 26

5:31 pm - 11:55 pm

MDW

GSP

5h 24m1 stop

7:20 am - 12:51 pm

GSP

MDW

6h 31m1 stop

$237Delta

Wed, Jan 14 - Tue, Jan 20

6:45 am - 2:15 pm

MDW

GSP

6h 30m1 stop

7:20 am - 12:48 pm

GSP

MDW

6h 28m1 stop

$242Delta

Fri, Jan 9 - Tue, Jan 13

10:05 am - 5:35 pm

MDW

GSP

6h 30m1 stop

10:05 am - 6:35 pm

GSP

MDW

9h 30m2 stops

$248Southwest

Sun, Jan 18 - Wed, Jan 21

6:40 pm - 11:43 pm

MDW

GSP

4h 03m1 stop

6:49 am - 10:06 am

GSP

MDW

4h 17m1 stop

$254Delta

Fri, Feb 13 - Sun, Feb 15

6:30 am - 2:05 pm

MDW

GSP

6h 35m1 stop

5:40 am - 9:56 am

GSP

MDW

5h 16m1 stop

$258Delta

Tue, Apr 14 - Sun, Apr 19

10:05 am - 5:35 pm

MDW

GSP

6h 30m1 stop

10:45 am - 6:10 pm

GSP

MDW

8h 25m1 stop

$263Southwest

Sun, Jan 18 - Sun, Jan 25

10:05 am - 5:35 pm

MDW

GSP

6h 30m1 stop

10:05 am - 2:55 pm

GSP

MDW

5h 50m1 stop

$276Southwest

Wed, Jan 7 - Wed, Jan 14

Delta flights from Chicago Midway Airport to Greenville

Our best Delta deals on Chicago Midway Airport to Greenville flight tickets

Delta

Jan 21

MDW6:14 pmChicago Midway

4h 36m

1 stop

GSP11:50 pmGreenville

Jan 28

GSP5:40 amGreenville

5h 13m

1 stop

MDW9:53 amChicago Midway

$215

Find similar

Delta

Apr 14

MDW6:30 amChicago Midway

6h 35m

1 stop

GSP2:05 pmGreenville

Apr 19

GSP5:40 pmGreenville

5h 49m

1 stop

MDW10:29 pmChicago Midway

$222

Find similar

Delta

Jan 19

MDW6:14 pmChicago Midway

4h 36m

1 stop

GSP11:50 pmGreenville

Jan 26

GSP5:12 pmGreenville

6h 10m

1 stop

MDW10:22 pmChicago Midway

$229

Find similar

Southwest flights from Chicago Midway Airport to Greenville

Our best Southwest deals on Chicago Midway Airport to Greenville flight tickets

Southwest

Jan 18

MDW10:05 amChicago Midway

6h 30m

1 stop

GSP5:35 pmGreenville

Jan 21

GSP10:05 amGreenville

9h 30m

2 stops

MDW6:35 pmChicago Midway

$248

Find similar

Southwest

Jan 18

MDW10:05 amChicago Midway

6h 30m

1 stop

GSP5:35 pmGreenville

Jan 25

GSP10:45 amGreenville

8h 25m

1 stop

MDW6:10 pmChicago Midway

$263

Find similar

Southwest

Jan 7

MDW10:05 amChicago Midway

6h 30m

1 stop

GSP5:35 pmGreenville

Jan 14

GSP10:05 amGreenville

5h 50m

1 stop

MDW2:55 pmChicago Midway

$276

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Chicago Midway Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Wed 1/21

6:14 pm-11:50 pm

1 stop4h 36m

Greenville

Wed 1/28

5:40 am-9:53 am

1 stop5h 13m

$215

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Tue 4/14

6:30 am-2:05 pm

1 stop6h 35m

Greenville

Sun 4/19

5:40 pm-10:29 pm

1 stop5h 49m

$222

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Fri 1/23

6:14 pm-11:50 pm

1 stop4h 36m

Greenville

Mon 1/26

5:12 pm-10:22 pm

1 stop6h 10m

$229

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Wed 1/14

5:31 pm-11:55 pm

1 stop5h 24m

Greenville

Tue 1/20

7:20 am-12:51 pm

1 stop6h 31m

$237

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Fri 1/9

6:45 am-2:15 pm

1 stop6h 30m

Greenville

Tue 1/13

7:20 am-12:48 pm

1 stop6h 28m

$242

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sun 1/18

10:05 am-5:35 pm

1 stop6h 30m

Greenville

Wed 1/21

10:05 am-6:35 pm

2 stops9h 30m

$248

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Fri 2/13

6:40 pm-11:43 pm

1 stop4h 03m

Greenville

Sun 2/15

6:49 am-10:06 am

1 stop4h 17m

$254

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Tue 4/14

6:30 am-2:05 pm

1 stop6h 35m

Greenville

Sun 4/19

5:40 am-9:56 am

1 stop5h 16m

$258

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sun 1/18

10:05 am-5:35 pm

1 stop6h 30m

Greenville

Sun 1/25

10:45 am-6:10 pm

1 stop8h 25m

$263

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Wed 1/7

10:05 am-5:35 pm

1 stop6h 30m

Greenville

Wed 1/14

10:05 am-2:55 pm

1 stop5h 50m

$276

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago Midway Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago Midway Airport. The lowest ticket price found for a Saturday departure recently was $273. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $418. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Chicago Midway Airport to Greenville during this time can be as low as $292. Flights to Greenville are more costly in the evening, with an average ticket price of $315. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Chicago Midway Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Chicago Midway Airport to Greenville (MDW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Greenville

Fastest flight time	3h 19m
Direct flights	None

The fastest flight from Chicago Midway Airport to Greenville takes 3h 19m

There are no direct flights from Chicago Midway Airport to Greenville. There are no popular flight routes from Chicago Midway Airport to Greenville.

Search flight deals

How far is Chicago Midway to Greenville by plane?
The straight-line distance from Chicago Midway to Greenville is 559.4 mi. A reasonable flight in good conditions will take 3h 19m.
When did momondo last update prices for flights from Chicago Midway Airport to Greenville Airport?
Prices for flights from Chicago Midway Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Chicago Midway Airport to Greenville Airport?
As of December 2025, there is 1 operator available to choose from for flights from Chicago Midway Airport to Greenville Airport.
How old do you have to be to fly from Chicago Midway Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago Midway Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Chicago Midway Airport to Greenville?
Based on momondo bookings for flights between Chicago Midway Airport and Greenville, the leading airline is Delta, making up 100% of the total bookings.

Best airlines flying from Chicago Midway Airport to Greenville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $214	Free Cancellation	Rating 7.9 8,014 reviews		Search Delta flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to Greenville for you.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Chicago to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Chicago to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from Chicago.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.