What is the cheapest airline that flies from Chicago Midway to Greenville?

Southwest, Delta, and Allegiant Air are the most popular carriers operating from Chicago Midway to Greenville

What airlines fly to Greenville?

Southwest, Delta and Allegiant Air are the top three most popular airlines that fly to Greenville from Chicago Midway Airport according to our data. Southwest is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Chicago Midway Airport to Greenville Airport?

Prices for flights from Chicago Midway Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Chicago Midway Airport to Greenville Airport?

As of September 2025, there are 2 operators available to choose from for flights from Chicago Midway Airport to Greenville Airport.

How old do you have to be to fly from Chicago Midway Airport to Greenville Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago Midway Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$75 Cheap Flights from Chicago Midway Airport to Greenville in 2025

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Find the cheapest flights from Chicago Midway Airport to Greenville

Round-trip

One-way

Last minute

Cheap round-trip flights

5:50 am - 1:00 pmMDW-GSP

6h 10m1 stop

3:05 pm - 10:10 pmGSP-MDW

8h 05m1 stop

$155Southwest

Find Deal

Sat, Nov 8 - Tue, Nov 11

5:50 am - 1:00 pmMDW-GSP

6h 10m1 stop

7:40 am - 1:00 pmGSP-MDW

6h 20m2 stops

$160Southwest

Find Deal

Sat, Nov 8 - Tue, Nov 11

5:34 pm - 11:55 pmMDW-GSP

5h 21m1 stop

7:27 am - 12:34 pmGSP-MDW

6h 07m1 stop

$197Delta

Find Deal

Thu, Nov 27 - Fri, Dec 5

5:34 pm - 11:55 pmMDW-GSP

5h 21m1 stop

7:27 am - 12:34 pmGSP-MDW

6h 07m1 stop

$213Delta

Find Deal

Mon, Nov 24 - Wed, Dec 3

6:00 am - 12:50 pmMDW-GSP

5h 50m1 stop

5:16 pm - 10:14 pmGSP-MDW

5h 58m1 stop

$215Delta

Find Deal

Wed, Oct 8 - Sat, Oct 11

5:04 pm - 11:55 pmMDW-GSP

5h 51m1 stop

5:16 pm - 10:14 pmGSP-MDW

5h 58m1 stop

$218Delta

Find Deal

Tue, Oct 21 - Fri, Oct 24

11:00 am - 4:16 pmMDW-GSP

4h 16m1 stop

5:16 pm - 10:14 pmGSP-MDW

5h 58m1 stop

$222Delta

Find Deal

Sat, Oct 4 - Sat, Oct 11

11:45 am - 6:05 pmMDW-GSP

5h 20m1 stop

3:25 pm - 8:25 pmGSP-MDW

6h 00m1 stop

$227Southwest

Find Deal

Wed, Sep 24 - Wed, Oct 1

4:25 pm - 11:34 pmMDW-GSP

6h 09m1 stop

7:30 am - 12:28 pmGSP-MDW

5h 58m1 stop

$229Delta

Find Deal

Sat, Oct 4 - Sun, Oct 12

8:19 am - 7:23 pmMDW-GSP

10h 04m1 stop

8:03 pm - 3:11 pmGSP-MDW

20h 08m1 stop

$242

Find Deal

Mon, Oct 6 - Fri, Oct 10

Southwest flights from Chicago Midway Airport to Greenville

Our best Southwest deals on Chicago Midway Airport to Greenville flight tickets

Southwest

Nov 8

MDW5:50 amChicago Midway

6h 10m

1 stop

GSP1:00 pmGreenville

Nov 11

GSP3:05 pmGreenville

8h 05m

1 stop

MDW10:10 pmChicago Midway

$155

Find similar

Southwest

Nov 8

MDW5:50 amChicago Midway

6h 10m

1 stop

GSP1:00 pmGreenville

Nov 11

GSP7:40 amGreenville

6h 20m

2 stops

MDW1:00 pmChicago Midway

$160

Find similar

Southwest

Sep 24

MDW11:45 amChicago Midway

5h 20m

1 stop

GSP6:05 pmGreenville

Oct 1

GSP3:25 pmGreenville

6h 00m

1 stop

MDW8:25 pmChicago Midway

$227

Find similar

Delta flights from Chicago Midway Airport to Greenville

Our best Delta deals on Chicago Midway Airport to Greenville flight tickets

Delta

Nov 27

MDW5:34 pmChicago Midway

5h 21m

1 stop

GSP11:55 pmGreenville

Dec 5

GSP7:27 amGreenville

6h 07m

1 stop

MDW12:34 pmChicago Midway

$197

Find similar

Delta

Nov 24

MDW5:34 pmChicago Midway

5h 21m

1 stop

GSP11:55 pmGreenville

Dec 3

GSP7:27 amGreenville

6h 07m

1 stop

MDW12:34 pmChicago Midway

$213

Find similar

Delta

Oct 8

MDW6:00 amChicago Midway

5h 50m

1 stop

GSP12:50 pmGreenville

Oct 11

GSP5:16 pmGreenville

5h 58m

1 stop

MDW10:14 pmChicago Midway

$215

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Chicago Midway Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sat 11/8

5:50 am-1:00 pm

1 stop6h 10m

Greenville

Tue 11/11

3:05 pm-10:10 pm

1 stop8h 05m

$155

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sat 11/8

5:50 am-1:00 pm

1 stop6h 10m

Greenville

Tue 11/11

7:40 am-1:00 pm

2 stops6h 20m

$160

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Thu 11/27

5:34 pm-11:55 pm

1 stop5h 21m

Greenville

Fri 12/5

7:27 am-12:34 pm

1 stop6h 07m

$197

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Mon 11/24

5:34 pm-11:55 pm

1 stop5h 21m

Greenville

Wed 12/3

7:27 am-12:34 pm

1 stop6h 07m

$213

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Wed 10/8

6:00 am-12:50 pm

1 stop5h 50m

Greenville

Sat 10/11

5:16 pm-10:14 pm

1 stop5h 58m

$215

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Tue 10/21

5:04 pm-11:55 pm

1 stop5h 51m

Greenville

Fri 10/24

5:16 pm-10:14 pm

1 stop5h 58m

$218

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sat 10/4

11:00 am-4:16 pm

1 stop4h 16m

Greenville

Sat 10/11

5:16 pm-10:14 pm

1 stop5h 58m

$222

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Wed 9/24

11:45 am-6:05 pm

1 stop5h 20m

Greenville

Wed 10/1

3:25 pm-8:25 pm

1 stop6h 00m

$227

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Sat 10/4

4:25 pm-11:34 pm

1 stop6h 09m

Greenville

Sun 10/12

7:30 am-12:28 pm

1 stop5h 58m

$229

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Mon 10/6

8:19 am-7:23 pm

1 stop10h 04m

Greenville

Fri 10/10

8:03 pm-3:11 pm

1 stop20h 08m

$242

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago Midway Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago Midway Airport. The lowest ticket price found for a Saturday departure recently was $290. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $407. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Chicago Midway Airport to Greenville during this time can be as low as $299. Flights to Greenville are more costly in the morning, with an average ticket price of $321. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Chicago Midway Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago Midway Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Chicago Midway Airport to Greenville (MDW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to Greenville

Direct flights	None

There are no direct flights from Chicago Midway Airport to Greenville. There are no popular flight routes from Chicago Midway Airport to Greenville.

Search flight deals

How far is Chicago Midway to Greenville by plane?
The straight-line distance from Chicago Midway to Greenville is 559.4 mi. A reasonable flight in good conditions will take 3h 33m.
When did momondo last update prices for flights from Chicago Midway Airport to Greenville Airport?
Prices for flights from Chicago Midway Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Chicago Midway Airport to Greenville Airport?
As of September 2025, there are 2 operators available to choose from for flights from Chicago Midway Airport to Greenville Airport.
How old do you have to be to fly from Chicago Midway Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago Midway Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Chicago Midway Airport to Greenville?
Based on momondo bookings for flights between Chicago Midway Airport and Greenville, the leading airline is Delta, making up 61% of the total bookings. Other popular airlines include Southwest with 39%.

Best airlines flying from Chicago Midway Airport to Greenville

Compare and see reviews for airlines that fly from Chicago Midway Airport to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $214	Free Cancellation	Rating 7.9 7,960 reviews		Search Delta flights
Southwest	PriceFrom $278	Free Cancellation	Rating 8.0 4,248 reviews		Search Southwest flights

Anderson

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Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to Greenville for you.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Chicago to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Chicago to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from Chicago.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.