Cheap flights from Michigan to St. Louis from $64

In general, June is the cheapest month to fly from Michigan to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $26. The month of September is another great option to travel to St. Louis, with average flight prices from Michigan averaging around $27.

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $315. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $412. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Michigan at noon is the least expensive time of day to depart. momondo users have found prices as low as $270 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $366 per ticket.

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Michigan - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Michigan when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $302 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Michigan for as low as $69 on momondo.

Southwest, Delta, and Frontier are the most popular carriers operating from Michigan to Lambert-St Louis

Delta, American Airlines and Southwest are the top three most popular airlines that fly to St. Louis from Michigan according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 6 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Michigan and St. Louis is 85 per day as of May 2026. The most frequent departure time is 4:00PM, with 50% of daily flights leaving in the afternoon.

595 flights are operational weekly from Michigan to St. Louis as of May 2026. The most popular departure day for this route is Fri, with 17% of flights per week taking off on this day.