Cheap flights from Michigan to St. Louis from $58

In general, September is the cheapest month to fly from Michigan to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $328. The month of December is another great option to travel to St. Louis, with average flight prices from Michigan averaging around $333.

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $382. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $482. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Michigan at noon is the least expensive time of day to depart. momondo users have found prices as low as $352 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $446 per ticket.

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Michigan - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Michigan when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Michigan for as low as $279 on momondo.

There are 4 cabin classes available to choose from on Michigan to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Delta, and Southwest are the most popular carriers operating from Michigan to Lambert-St Louis

Delta, Southwest and United Airlines are the top three most popular airlines that fly to St. Louis from Michigan according to our data. Delta is the first choice among our users, with 43% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Michigan and St. Louis is 9 per day as of October 2026. The most frequent departure time is 7:00PM, with 51% of daily flights leaving in the afternoon.

69 flights are operational weekly from Michigan to St. Louis as of October 2026. The most popular departure day for this route is Wed, with 23% of flights per week taking off on this day.