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Cheap flights from Medford to Des Moines from $333

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Des Moines departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
12:55 pm - 8:34 pm
MFR
-
DSM
5h 39m1 stop
United Airlines Logo
9:03 am - 1:19 pm
DSM
-
MFR
6h 16m1 stop
$369United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
12:55 pm - 8:34 pm
MFR
-
DSM
5h 39m1 stop
United Airlines Logo
1:35 pm - 10:59 pm
DSM
-
MFR
11h 24m2 stops
$374United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
12:55 pm - 8:34 pm
MFR
-
DSM
5h 39m1 stop
United Airlines Logo
8:00 am - 10:59 pm
DSM
-
MFR
16h 59m3 stops
$379United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
6:49 am - 8:32 pm
MFR
-
DSM
11h 43m2 stops
United Airlines Logo
5:03 pm - 9:10 pm
DSM
-
MFR
6h 07m1 stop
$408United Airlines
Wed, May 13 - Wed, May 20
United Airlines Logo
12:45 pm - 8:32 pm
MFR
-
DSM
5h 47m1 stop
United Airlines Logo
5:03 pm - 9:10 pm
DSM
-
MFR
6h 07m1 stop
$409United Airlines
Wed, May 13 - Wed, May 20
United Airlines Logo
6:00 am - 8:34 pm
MFR
-
DSM
12h 34m2 stops
United Airlines Logo
8:00 am - 10:59 pm
DSM
-
MFR
16h 59m3 stops
$444United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
5:02 am - 12:49 pm
MFR
-
DSM
5h 47m1 stop
United Airlines Logo
5:03 pm - 9:18 pm
DSM
-
MFR
6h 15m1 stop
$472United Airlines
Sat, Feb 14 - Mon, Feb 16
United Airlines Logo
2:00 pm - 11:43 pm
MFR
-
DSM
7h 43m2 stops
United Airlines Logo
5:03 pm - 9:18 pm
DSM
-
MFR
6h 15m1 stop
$483United Airlines
Sat, Feb 14 - Mon, Feb 16
United Airlines Logo
6:00 am - 8:34 pm
MFR
-
DSM
12h 34m2 stops
United Airlines Logo
8:00 am - 10:59 pm
DSM
-
MFR
16h 59m3 stops
$489United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
6:49 am - 8:32 pm
MFR
-
DSM
11h 43m2 stops
United Airlines Logo
5:03 pm - 9:10 pm
DSM
-
MFR
6h 07m1 stop
$494United Airlines
Wed, May 13 - Wed, May 20

United Airlines flights from Medford to Des Moines

Our best United Airlines deals on Medford to Des Moines flight tickets
United Airlines
Jan 17
MFR12:55 pmMedford
5h 39m
1 stop
DSM8:34 pmDes Moines
Jan 21
DSM5:09 pmDes Moines
5h 53m
1 stop
MFR9:02 pmMedford
$369
Find similar
United Airlines
Jan 17
MFR12:55 pmMedford
5h 39m
1 stop
DSM8:34 pmDes Moines
Jan 21
DSM9:03 amDes Moines
10h 39m
2 stops
MFR5:42 pmMedford
$374
Find similar
United Airlines
Jan 17
MFR12:55 pmMedford
5h 39m
1 stop
DSM8:34 pmDes Moines
Jan 21
DSM8:00 amDes Moines
16h 59m
3 stops
MFR10:59 pmMedford
$379
Find similar

Alaska Airlines flights from Medford to Des Moines

Our best Alaska Airlines deals on Medford to Des Moines flight tickets
Alaska Airlines
May 13
MFR5:14 amMedford
15h 26m
2 stops
DSM10:40 pmDes Moines
May 20
DSM5:46 amDes Moines
13h 22m
2 stops
MFR5:08 pmMedford
$509
Find similar
Alaska Airlines
Feb 14
MFR3:38 pmMedford
24h 19m
2 stops
DSM5:57 pmDes Moines
Feb 16
DSM10:09 amDes Moines
15h 50m
2 stops
MFR11:59 pmMedford
$564
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 17, 2025.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 1/17

12:55 pm-8:34 pm

1 stop5h 39m

Des Moines

Wed 1/21

9:03 am-1:19 pm

1 stop6h 16m

$369

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 1/17

12:55 pm-8:34 pm

1 stop5h 39m

Des Moines

Wed 1/21

1:35 pm-10:59 pm

2 stops11h 24m

$374

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 1/17

12:55 pm-8:34 pm

1 stop5h 39m

Des Moines

Wed 1/21

8:00 am-10:59 pm

3 stops16h 59m

$379

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 5/13

6:49 am-8:32 pm

2 stops11h 43m

Des Moines

Wed 5/20

5:03 pm-9:10 pm

1 stop6h 07m

$408

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 5/13

12:45 pm-8:32 pm

1 stop5h 47m

Des Moines

Wed 5/20

5:03 pm-9:10 pm

1 stop6h 07m

$409

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 1/17

6:00 am-8:34 pm

2 stops12h 34m

Des Moines

Wed 1/21

8:00 am-10:59 pm

3 stops16h 59m

$444

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 2/14

5:02 am-12:49 pm

1 stop5h 47m

Des Moines

Mon 2/16

5:03 pm-9:18 pm

1 stop6h 15m

$472

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 2/14

2:00 pm-11:43 pm

2 stops7h 43m

Des Moines

Mon 2/16

5:03 pm-9:18 pm

1 stop6h 15m

$483

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 1/17

6:00 am-8:34 pm

2 stops12h 34m

Des Moines

Wed 1/21

8:00 am-10:59 pm

3 stops16h 59m

$489

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 5/13

6:49 am-8:32 pm

2 stops11h 43m

Des Moines

Wed 5/20

5:03 pm-9:10 pm

1 stop6h 07m

$494

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Medford to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Medford and Des Moines?

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Medford to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $434. Flights from Medford to Des Moines on a Sunday will generally be more expensive and average around $781. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Medford to Des Moines in the morning for as low as $466. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $512. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Medford to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Des Moines (MFR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Des Moines

Fastest flight time

5h 39m

Direct flights

None
The fastest flight from Medford to Des Moines takes 5h 39m
There are no direct flights from Medford to Des Moines. There are no popular flight routes from Medford to Des Moines.
Search flight deals

  • How far is Medford to Des Moines by plane?

    A flight from Medford to Des Moines will travel around 1495.2 mi. A reasonable flight in good conditions will take 5h 39m.

  • When did momondo last update prices for flights from Medford Airport to Des Moines Airport?

    Prices for flights from Medford Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Medford Airport to Des Moines Airport?

  • How old do you have to be to fly from Medford Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Medford Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Medford to Des Moines?

Best airlines flying from Medford to Des Moines

Compare and see reviews for airlines that fly from Medford to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $266Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Medford to Des Moines for you.

Can I find flights from Medford to Des Moines with flexible booking policies on momondo?

All flight searches from Medford to Des Moines on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Medford to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Medford to Des Moines.

I’m not ready to book a flight from Medford to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Medford and alert you when they change.

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