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Cheap flights from Medford to Des Moines from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Des Moines departing on 6/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:10 am - 12:34 pm
MFR
-
DSM
5h 24m
1 stop
United Airlines Logo
5:03 pm - 9:10 pm
DSM
-
MFR
6h 07m
1 stop
$419United Airlines
Sat, Nov 14 - Tue, Nov 17
United Airlines Logo
12:45 pm - 8:32 pm
MFR
-
DSM
5h 47m
1 stop
United Airlines Logo
1:45 pm - 11:09 pm
DSM
-
MFR
11h 24m
2 stops
$424United Airlines
Sat, Nov 14 - Tue, Nov 17
United Airlines Logo
5:00 am - 12:32 pm
MFR
-
DSM
5h 32m
1 stop
United Airlines Logo
5:21 pm - 9:08 pm
DSM
-
MFR
5h 47m
1 stop
$425United Airlines
Tue, Aug 25 - Thu, Sep 3
Alaska Airlines Logo
6:46 pm - 8:34 am
MFR
-
DSM
11h 48m
2 stops
Alaska Airlines Logo
5:00 am - 2:36 pm
DSM
-
MFR
11h 36m
2 stops
$429Alaska Airlines
Sat, Nov 14 - Tue, Nov 17
Alaska Airlines Logo
7:00 am - 11:15 pm
MFR
-
DSM
14h 15m
2 stops
Alaska Airlines Logo
4:13 pm - 9:51 am
DSM
-
MFR
19h 38m
2 stops
$484Alaska Airlines
Tue, Aug 25 - Thu, Sep 3
United Airlines Logo
6:00 am - 8:26 pm
MFR
-
DSM
12h 26m
2 stops
United Airlines Logo
5:21 pm - 9:08 pm
DSM
-
MFR
5h 47m
1 stop
$503United Airlines
Tue, Aug 25 - Thu, Sep 3
United Airlines Logo
5:00 am - 12:32 pm
MFR
-
DSM
5h 32m
1 stop
United Airlines Logo
5:21 pm - 9:08 pm
DSM
-
MFR
5h 47m
1 stop
$518United Airlines
Tue, Aug 25 - Thu, Sep 3
Alaska Airlines Logo
7:00 am - 11:15 pm
MFR
-
DSM
14h 15m
2 stops
Alaska Airlines Logo
10:26 am - 6:47 pm
DSM
-
MFR
10h 21m
2 stops
$529Alaska Airlines
Tue, Aug 25 - Thu, Sep 3
United Airlines Logo
6:00 am - 8:26 pm
MFR
-
DSM
12h 26m
2 stops
United Airlines Logo
5:21 pm - 9:08 pm
DSM
-
MFR
5h 47m
1 stop
$573United Airlines
Tue, Aug 25 - Thu, Sep 3
United Airlines Logo
5:00 am - 12:32 pm
MFR
-
DSM
5h 32m
1 stop
United Airlines Logo
5:45 am - 12:02 pm
DSM
-
MFR
8h 17m
2 stops
$578United Airlines
Tue, Aug 25 - Thu, Sep 3

United Airlines flights from Medford to Des Moines

Our best United Airlines deals on Medford to Des Moines flight tickets
United Airlines
May 21
MFR5:00 amMedford
5h 36m
1 stop
DSM12:36 pmDes Moines
May 29
DSM11:23 amDes Moines
13h 36m
2 stops
MFR10:59 pmMedford
$559
United Airlines
May 21
MFR1:10 pmMedford
5h 20m
1 stop
DSM8:30 pmDes Moines
May 29
DSM11:23 amDes Moines
13h 36m
2 stops
MFR10:59 pmMedford
$594
United Airlines
May 21
MFR5:00 amMedford
5h 36m
1 stop
DSM12:36 pmDes Moines
May 29
DSM5:17 pmDes Moines
5h 59m
1 stop
MFR9:16 pmMedford
$619

American Airlines flights from Medford to Des Moines

Our best American Airlines deals on Medford to Des Moines flight tickets
American Airlines
Jun 20
MFR1:24 pmMedford
8h 23m
1 stop
DSM11:47 pmDes Moines
Aug 22
DSM2:39 pmDes Moines
6h 41m
1 stop
MFR7:20 pmMedford
$623
American Airlines
Jun 17
MFR1:24 pmMedford
8h 23m
1 stop
DSM11:47 pmDes Moines
Jun 24
DSM5:45 amDes Moines
9h 05m
1 stop
MFR12:50 pmMedford
$731
American Airlines
May 24
MFR1:24 pmMedford
8h 23m
1 stop
DSM11:47 pmDes Moines
May 26
DSM5:45 amDes Moines
9h 05m
1 stop
MFR12:50 pmMedford
$975

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 11/14

5:10 am-12:34 pm

1 stop5h 24m

Des Moines

Tue 11/17

5:03 pm-9:10 pm

1 stop6h 07m

$419

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 11/14

12:45 pm-8:32 pm

1 stop5h 47m

Des Moines

Tue 11/17

1:45 pm-11:09 pm

2 stops11h 24m

$424
Quickest round-trip

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

5:00 am-12:32 pm

1 stop5h 32m

Des Moines

Thu 9/3

5:21 pm-9:08 pm

1 stop5h 47m

$425

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 11/14

6:46 pm-8:34 am

2 stops11h 48m

Des Moines

Tue 11/17

5:00 am-2:36 pm

2 stops11h 36m

$429

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

7:00 am-11:15 pm

2 stops14h 15m

Des Moines

Thu 9/3

4:13 pm-9:51 am

2 stops19h 38m

$484

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

6:00 am-8:26 pm

2 stops12h 26m

Des Moines

Thu 9/3

5:21 pm-9:08 pm

1 stop5h 47m

$503

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

5:00 am-12:32 pm

1 stop5h 32m

Des Moines

Thu 9/3

5:21 pm-9:08 pm

1 stop5h 47m

$518

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

7:00 am-11:15 pm

2 stops14h 15m

Des Moines

Thu 9/3

10:26 am-6:47 pm

2 stops10h 21m

$529

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

6:00 am-8:26 pm

2 stops12h 26m

Des Moines

Thu 9/3

5:21 pm-9:08 pm

1 stop5h 47m

$573

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Tue 8/25

5:00 am-12:32 pm

1 stop5h 32m

Des Moines

Thu 9/3

5:45 am-12:02 pm

2 stops8h 17m

$578

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Medford to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Medford to Des Moines?

Allegiant Air and United Airlines are the most popular carriers operating from Medford to Des Moines

When to book flights from Medford to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Des Moines (MFR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Des Moines

Fastest flight time

5h 18m

Direct flights

None
The fastest flight from Medford to Des Moines takes 5h 18m
There are no direct flights from Medford to Des Moines. There are no popular flight routes from Medford to Des Moines.
Search flight deals

Frequently asked questions about flying from Medford to Des Moines

  • How far is Medford to Des Moines by plane?

    A flight from Medford to Des Moines will travel around 1495.2 mi. A reasonable flight in good conditions will take 5h 18m.

  • When did momondo last update prices for flights from Medford Airport to Des Moines Airport?

    Prices for flights from Medford Airport to Des Moines Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Medford Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Medford Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Medford to Des Moines for you.

Can I find flights from Medford to Des Moines with flexible booking policies on momondo?

All flight searches from Medford to Des Moines on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Medford to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Medford to Des Moines.

I’m not ready to book a flight from Medford to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Medford and alert you when they change.

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