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Cheap flights from Medford to Des Moines from $268

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Des Moines departing on 11/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:10 am - 12:34 pmMFR-DSM
5h 24m1 stop
United Airlines Logo
9:09 am - 1:09 pmDSM-MFR
6h 00m1 stop
$374United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
United Airlines Logo
6:35 pm - 10:20 amMFR-DSM
13h 45m2 stops
United Airlines Logo
5:03 pm - 9:10 pmDSM-MFR
6h 07m1 stop
$379United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
United Airlines Logo
6:35 pm - 10:20 amMFR-DSM
13h 45m2 stops
United Airlines Logo
11:30 am - 8:30 pmDSM-MFR
11h 00m2 stops
$445United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
United Airlines Logo
6:35 pm - 10:20 amMFR-DSM
13h 45m2 stops
United Airlines Logo
8:00 am - 8:30 pmDSM-MFR
14h 30m3 stops
$467United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
Allegiant Air Logo
4:40 pm - 10:40 pmMFR-DSM
28h 00m1 stop
Allegiant Air Logo
9:00 am - 3:50 pmDSM-MFR
8h 50m1 stop
$556Allegiant Air
Find Deal
Sun, Nov 9 - Thu, Nov 13
Multiple Airlines Logo
4:40 pm - 1:47 pmMFR-DSM
19h 07m2 stops
Multiple Airlines Logo
9:00 am - 3:50 pmDSM-MFR
8h 50m1 stop
$584Multiple Airlines
Find Deal
Sun, Nov 9 - Thu, Nov 13
United Airlines Logo
2:05 pm - 11:39 pmMFR-DSM
7h 34m2 stops
United Airlines Logo
8:00 am - 8:30 pmDSM-MFR
14h 30m3 stops
$600United Airlines
Find Deal
Wed, Apr 15 - Sat, Apr 18
Delta Logo
5:00 am - 5:12 pmMFR-DSM
10h 12m2 stops
Delta Logo
2:45 pm - 11:32 pmDSM-MFR
10h 47m2 stops
$655Delta
Find Deal
Sun, Nov 9 - Thu, Nov 13
Alaska Airlines Logo
8:48 am - 11:59 pmMFR-DSM
13h 11m3 stops
Alaska Airlines Logo
11:30 am - 8:07 pmDSM-MFR
10h 37m2 stops
$935Alaska Airlines
Find Deal
Sun, Nov 9 - Thu, Nov 13

United Airlines flights from Medford to Des Moines

Our best United Airlines deals on Medford to Des Moines flight tickets
United Airlines
Apr 15
MFR5:10 amMedford
5h 24m
1 stop
DSM12:34 pmDes Moines
Apr 18
DSM9:09 amDes Moines
6h 00m
1 stop
MFR1:09 pmMedford
$374
Find similar
United Airlines
Apr 15
MFR6:35 pmMedford
13h 45m
2 stops
DSM10:20 amDes Moines
Apr 18
DSM5:03 pmDes Moines
6h 07m
1 stop
MFR9:10 pmMedford
$379
Find similar
United Airlines
Apr 15
MFR6:35 pmMedford
13h 45m
2 stops
DSM10:20 amDes Moines
Apr 18
DSM11:30 amDes Moines
11h 00m
2 stops
MFR8:30 pmMedford
$445
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

5:10 am-12:34 pm

1 stop5h 24m

Des Moines

Sat 4/18

9:09 am-1:09 pm

1 stop6h 00m

$374

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

6:35 pm-10:20 am

2 stops13h 45m

Des Moines

Sat 4/18

5:03 pm-9:10 pm

1 stop6h 07m

$379

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

6:35 pm-10:20 am

2 stops13h 45m

Des Moines

Sat 4/18

11:30 am-8:30 pm

2 stops11h 00m

$445

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

6:35 pm-10:20 am

2 stops13h 45m

Des Moines

Sat 4/18

8:00 am-8:30 pm

3 stops14h 30m

$467

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sun 11/9

4:40 pm-10:40 pm

1 stop28h 00m

Des Moines

Thu 11/13

9:00 am-3:50 pm

1 stop8h 50m

$556

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sun 11/9

4:40 pm-1:47 pm

2 stops19h 07m

Des Moines

Thu 11/13

9:00 am-3:50 pm

1 stop8h 50m

$584

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Wed 4/15

2:05 pm-11:39 pm

2 stops7h 34m

Des Moines

Sat 4/18

8:00 am-8:30 pm

3 stops14h 30m

$600

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sun 11/9

5:00 am-5:12 pm

2 stops10h 12m

Des Moines

Thu 11/13

2:45 pm-11:32 pm

2 stops10h 47m

$655

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sun 11/9

8:48 am-11:59 pm

3 stops13h 11m

Des Moines

Thu 11/13

11:30 am-8:07 pm

2 stops10h 37m

$935

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 11/27

5:00 am-12:31 pm

1 stop5h 31m

$268

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Medford to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then January is your next best option. Flight prices from Medford to Des Moines during January average around $378.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Medford to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $434. Flights from Medford to Des Moines on a Sunday will generally be more expensive and average around $781. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Medford to Des Moines in the morning for as low as $466. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $512. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Medford to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Des Moines (MFR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Des Moines

Direct flights

None
There are no direct flights from Medford to Des Moines. There are no popular flight routes from Medford to Des Moines.
Search flight deals

  • How far is Medford to Des Moines by plane?

    A flight from Medford to Des Moines will travel around 1495.2 mi. A reasonable flight in good conditions will take 5h 24m.

  • When did momondo last update prices for flights from Medford Airport to Des Moines Airport?

    Prices for flights from Medford Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Medford Airport to Des Moines Airport?

  • How old do you have to be to fly from Medford Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Medford Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Medford to Des Moines?

Best airlines flying from Medford to Des Moines

Compare and see reviews for airlines that fly from Medford to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $266Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Medford to Des Moines for you.

Can I find flights from Medford to Des Moines with flexible booking policies on momondo?

All flight searches from Medford to Des Moines on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Medford to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Medford to Des Moines.

I’m not ready to book a flight from Medford to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Medford and alert you when they change.

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