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Cheap flights from Medford to Des Moines from $324

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Des Moines departing on 9/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Des Moines

Cheap round-trip flights

United Airlines Logo
6:35 pm - 10:39 amMFR-DSM
14h 04m2 stops
United Airlines Logo
5:15 pm - 9:04 pmDSM-MFR
5h 49m1 stop
$324United Airlines
Find Deal
Fri, Sep 19 - Tue, Sep 23
Delta Logo
5:23 pm - 9:40 amMFR-DSM
14h 17m2 stops
Delta Logo
2:54 pm - 11:31 pmDSM-MFR
10h 37m2 stops
$347Delta
Find Deal
Sat, Dec 6 - Wed, Dec 10
Alaska Airlines Logo
8:20 am - 10:59 pmMFR-DSM
12h 39m2 stops
Alaska Airlines Logo
11:29 am - 8:06 pmDSM-MFR
10h 37m2 stops
$359Alaska Airlines
Find Deal
Sat, Dec 6 - Wed, Dec 10
American Airlines Logo
1:45 pm - 11:54 pmMFR-DSM
8h 09m1 stop
American Airlines Logo
5:10 am - 1:07 pmDSM-MFR
9h 57m1 stop
$367American Airlines
Find Deal
Thu, Nov 20 - Tue, Nov 25
American Airlines Logo
3:00 pm - 11:59 pmMFR-DSM
6h 59m1 stop
American Airlines Logo
2:33 pm - 8:31 pmDSM-MFR
7h 58m1 stop
$409American Airlines
Find Deal
Sat, Dec 6 - Wed, Dec 10
United Airlines Logo
6:35 pm - 10:39 amMFR-DSM
14h 04m2 stops
United Airlines Logo
8:00 am - 10:19 pmDSM-MFR
16h 19m3 stops
$414United Airlines
Find Deal
Fri, Sep 19 - Tue, Sep 23
United Airlines Logo
5:00 am - 8:48 pmMFR-DSM
13h 48m1 stop
United Airlines Logo
8:00 am - 5:54 pmDSM-MFR
11h 54m2 stops
$437United Airlines
Find Deal
Sat, Dec 6 - Wed, Dec 10
United Airlines Logo
5:00 am - 12:36 pmMFR-DSM
5h 36m1 stop
United Airlines Logo
5:15 pm - 9:04 pmDSM-MFR
5h 49m1 stop
$444United Airlines
Find Deal
Fri, Sep 19 - Tue, Sep 23
United Airlines Logo
6:35 pm - 10:39 amMFR-DSM
14h 04m2 stops
United Airlines Logo
9:08 am - 5:51 pmDSM-MFR
10h 43m2 stops
$453United Airlines
Find Deal
Fri, Sep 19 - Tue, Sep 23
Alaska Airlines Logo
12:39 pm - 8:21 amMFR-DSM
17h 42m2 stops
Alaska Airlines Logo
1:07 pm - 12:15 amDSM-MFR
13h 08m2 stops
$683Alaska Airlines
Find Deal
Thu, Nov 20 - Tue, Nov 25

United Airlines flights from Medford to Des Moines

Our best United Airlines deals on Medford to Des Moines flight tickets
United Airlines
Sep 19
MFR6:35 pmMedford
14h 04m
2 stops
DSM10:39 amDes Moines
Sep 23
DSM5:15 pmDes Moines
5h 49m
1 stop
MFR9:04 pmMedford
$324
Find similar
United Airlines
Sep 6
MFR6:00 amMedford
12h 29m
2 stops
DSM8:29 pmDes Moines
Sep 14
DSM5:15 pmDes Moines
5h 49m
1 stop
MFR9:04 pmMedford
$389
Find similar
United Airlines
Sep 8
MFR5:00 amMedford
5h 36m
1 stop
DSM12:36 pmDes Moines
Sep 14
DSM5:15 pmDes Moines
5h 49m
1 stop
MFR9:04 pmMedford
$409
Find similar

Delta flights from Medford to Des Moines

Our best Delta deals on Medford to Des Moines flight tickets
Delta
Dec 6
MFR5:23 pmMedford
14h 17m
2 stops
DSM9:40 amDes Moines
Dec 10
DSM2:54 pmDes Moines
10h 37m
2 stops
MFR11:31 pmMedford
$347
Find similar
Delta
Sep 5
MFR5:15 amMedford
9h 57m
2 stops
DSM5:12 pmDes Moines
Sep 15
DSM2:49 pmDes Moines
10h 01m
2 stops
MFR10:50 pmMedford
$496
Find similar
Delta
Sep 9
MFR6:00 amMedford
9h 12m
2 stops
DSM5:12 pmDes Moines
Sep 15
DSM2:49 pmDes Moines
10h 01m
2 stops
MFR10:50 pmMedford
$521
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 4, 2025.
Use the filters below to find and compare flights from Medford to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 9/19

6:35 pm-10:39 am

2 stops14h 04m

Des Moines

Tue 9/23

5:15 pm-9:04 pm

1 stop5h 49m

$324

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 12/6

5:23 pm-9:40 am

2 stops14h 17m

Des Moines

Wed 12/10

2:54 pm-11:31 pm

2 stops10h 37m

$347

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 12/6

8:20 am-10:59 pm

2 stops12h 39m

Des Moines

Wed 12/10

11:29 am-8:06 pm

2 stops10h 37m

$359

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 11/20

1:45 pm-11:54 pm

1 stop8h 09m

Des Moines

Tue 11/25

5:10 am-1:07 pm

1 stop9h 57m

$367

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 12/6

3:00 pm-11:59 pm

1 stop6h 59m

Des Moines

Wed 12/10

2:33 pm-8:31 pm

1 stop7h 58m

$409

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 9/19

6:35 pm-10:39 am

2 stops14h 04m

Des Moines

Tue 9/23

8:00 am-10:19 pm

3 stops16h 19m

$414

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Sat 12/6

5:00 am-8:48 pm

1 stop13h 48m

Des Moines

Wed 12/10

8:00 am-5:54 pm

2 stops11h 54m

$437

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 9/19

5:00 am-12:36 pm

1 stop5h 36m

Des Moines

Tue 9/23

5:15 pm-9:04 pm

1 stop5h 49m

$444

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Fri 9/19

6:35 pm-10:39 am

2 stops14h 04m

Des Moines

Tue 9/23

9:08 am-5:51 pm

2 stops10h 43m

$453

MedfordDes Moines

MFR - DSM

MFRDSM

Medford

Thu 11/20

12:39 pm-8:21 am

2 stops17h 42m

Des Moines

Tue 11/25

1:07 pm-12:15 am

2 stops13h 08m

$683

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Medford to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Medford and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in January, then December is your next best option. Flight prices from Medford to Des Moines during December average around $378.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Medford to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $434. Flights from Medford to Des Moines on a Sunday will generally be more expensive and average around $781. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Medford to Des Moines in the morning for as low as $466. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $512. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Medford to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Des Moines (MFR to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Des Moines

Direct flights

None
There are no direct flights from Medford to Des Moines. There are no popular flight routes from Medford to Des Moines.
Search flight deals

  • How far is Medford to Des Moines by plane?

    A flight from Medford to Des Moines will travel around 1495.2 mi. A reasonable flight in good conditions will take 5h 36m.

  • When did momondo last update prices for flights from Medford Airport to Des Moines Airport?

    Prices for flights from Medford Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Medford Airport to Des Moines Airport?

  • How old do you have to be to fly from Medford Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Medford Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Medford to Des Moines?

Best airlines flying from Medford to Des Moines

Compare and see reviews for airlines that fly from Medford to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $266Free CancellationRating
7.4
8,937 reviews
Search United Airlines flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Des Moines?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Medford to Des Moines for you.

Can I find flights from Medford to Des Moines with flexible booking policies on momondo?

All flight searches from Medford to Des Moines on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Medford to Des Moines?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Medford to Des Moines.

I’m not ready to book a flight from Medford to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Medford and alert you when they change.

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