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Cheap flights from Manchester, New Hampshire to South America from $475

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to South America departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Manchester, New Hampshire to South America

Cheap round-trip flights

United Airlines Logo
9:30 am - 9:05 pmMHT-MDE
12h 35m2 stops
United Airlines Logo
9:45 am - 11:44 pmMDE-MHT
12h 59m2 stops
$475United Airlines
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Tue, Oct 28 - Sat, Nov 1
United Airlines Logo
9:30 am - 9:05 pmMHT-MDE
36h 35m2 stops
United Airlines Logo
9:45 am - 11:44 pmMDE-MHT
12h 59m2 stops
$491United Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1
United Airlines Logo
1:30 pm - 9:10 pmMHT-MDE
32h 40m2 stops
United Airlines Logo
9:45 am - 3:02 pmMDE-MHT
28h 17m2 stops
$498United Airlines
Find Deal
Fri, Sep 19 - Fri, Sep 26
American Airlines Logo
8:00 am - 7:48 pmMHT-GYE
36h 48m2 stops
American Airlines Logo
8:15 am - 9:36 amGYE-MHT
24h 21m2 stops
$530American Airlines
Find Deal
Sat, Oct 4 - Tue, Oct 7
American Airlines Logo
5:48 pm - 12:25 pmMHT-CTG
19h 37m2 stops
American Airlines Logo
1:25 pm - 11:38 amCTG-MHT
21h 13m2 stops
$589American Airlines
Find Deal
Thu, Sep 18 - Thu, Sep 25
American Airlines Logo
11:25 am - 7:48 pmMHT-GYE
33h 23m2 stops
American Airlines Logo
8:15 am - 9:36 amGYE-MHT
24h 21m2 stops
$597American Airlines
Find Deal
Sat, Oct 4 - Tue, Oct 7
American Airlines Logo
6:00 am - 8:15 pmMHT-MDE
15h 15m2 stops
American Airlines Logo
12:40 am - 9:13 pmMDE-MHT
19h 33m2 stops
$703American Airlines
Find Deal
Fri, Aug 15 - Fri, Aug 22
American Airlines Logo
5:27 pm - 12:25 pmMHT-CTG
19h 58m2 stops
American Airlines Logo
1:25 pm - 2:52 pmCTG-MHT
24h 27m2 stops
$813American Airlines
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Fri, Aug 29 - Tue, Sep 2
Logo
7:45 pm - 5:55 pmMHT-SCL
44h 10m2 stops
Logo
6:30 pm - 9:58 amSCL-MHT
41h 28m2 stops
$845
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Mon, Dec 1 - Thu, Dec 4
United Airlines Logo
2:32 pm - 8:50 amMHT-SCL
40h 18m2 stops
United Airlines Logo
10:45 pm - 6:49 pmSCL-MHT
22h 04m2 stops
$846United Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9

United Airlines flights from Manchester, New Hampshire to South America

Our best United Airlines deals on Manchester, New Hampshire to South America flight tickets
United Airlines
Oct 28
MHT9:30 amManchester
12h 35m
2 stops
MDE9:05 pmMedellín Jose Maria Cordova Intl
Nov 1
MDE9:45 amMedellín Jose Maria Cordova Intl
12h 59m
2 stops
MHT11:44 pmManchester
$475
Find similar
United Airlines
Oct 28
MHT9:30 amManchester
36h 35m
2 stops
MDE9:05 pmMedellín Jose Maria Cordova Intl
Nov 1
MDE9:45 amMedellín Jose Maria Cordova Intl
12h 59m
2 stops
MHT11:44 pmManchester
$491
Find similar
United Airlines
Sep 19
MHT1:30 pmManchester
32h 40m
2 stops
MDE9:10 pmMedellín Jose Maria Cordova Intl
Sep 26
MDE9:45 amMedellín Jose Maria Cordova Intl
28h 17m
2 stops
MHT3:02 pmManchester
$498
Find similar

American Airlines flights from Manchester, New Hampshire to South America

Our best American Airlines deals on Manchester, New Hampshire to South America flight tickets
American Airlines
Oct 4
MHT8:00 amManchester
36h 48m
2 stops
GYE7:48 pmGuayaquil Jose Joaquin de Olmedo
Oct 7
GYE8:15 amGuayaquil Jose Joaquin de Olmedo
24h 21m
2 stops
MHT9:36 amManchester
$530
Find similar
American Airlines
Sep 18
MHT5:48 pmManchester
19h 37m
2 stops
CTG12:25 pmCartagena Rafael Nunez
Sep 25
CTG1:25 pmCartagena Rafael Nunez
21h 13m
2 stops
MHT11:38 amManchester
$589
Find similar
American Airlines
Oct 4
MHT11:25 amManchester
33h 23m
2 stops
GYE7:48 pmGuayaquil Jose Joaquin de Olmedo
Oct 7
GYE8:15 amGuayaquil Jose Joaquin de Olmedo
24h 21m
2 stops
MHT9:36 amManchester
$597
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2025.
Use the filters below to find and compare flights from Manchester, New Hampshire to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterMedellín

MHT - MDE

MHTMDE

Manchester

Tue 10/28

9:30 am-9:05 pm

2 stops12h 35m

Medellín Jose Maria Cordova Intl

Sat 11/1

9:45 am-11:44 pm

2 stops12h 59m

$475

ManchesterMedellín

MHT - MDE

MHTMDE

Manchester

Tue 10/28

9:30 am-9:05 pm

2 stops36h 35m

Medellín Jose Maria Cordova Intl

Sat 11/1

9:45 am-11:44 pm

2 stops12h 59m

$491

ManchesterMedellín

MHT - MDE

MHTMDE

Manchester

Fri 9/19

1:30 pm-9:10 pm

2 stops32h 40m

Medellín Jose Maria Cordova Intl

Fri 9/26

9:45 am-3:02 pm

2 stops28h 17m

$498

ManchesterGuayaquil

MHT - GYE

MHTGYE

Manchester

Sat 10/4

8:00 am-7:48 pm

2 stops36h 48m

Guayaquil Jose Joaquin de Olmedo

Tue 10/7

8:15 am-9:36 am

2 stops24h 21m

$530

ManchesterCartagena

MHT - CTG

MHTCTG

Manchester

Thu 9/18

5:48 pm-12:25 pm

2 stops19h 37m

Cartagena Rafael Nunez

Thu 9/25

1:25 pm-11:38 am

2 stops21h 13m

$589

ManchesterGuayaquil

MHT - GYE

MHTGYE

Manchester

Sat 10/4

11:25 am-7:48 pm

2 stops33h 23m

Guayaquil Jose Joaquin de Olmedo

Tue 10/7

8:15 am-9:36 am

2 stops24h 21m

$597

ManchesterMedellín

MHT - MDE

MHTMDE

Manchester

Fri 8/15

6:00 am-8:15 pm

2 stops15h 15m

Medellín Jose Maria Cordova Intl

Fri 8/22

12:40 am-9:13 pm

2 stops19h 33m

$703

ManchesterCartagena

MHT - CTG

MHTCTG

Manchester

Fri 8/29

5:27 pm-12:25 pm

2 stops19h 58m

Cartagena Rafael Nunez

Tue 9/2

1:25 pm-2:52 pm

2 stops24h 27m

$813

ManchesterSantiago

MHT - SCL

MHTSCL

Manchester

Mon 12/1

7:45 pm-5:55 pm

2 stops44h 10m

Santiago Arturo Merino Benitez

Thu 12/4

6:30 pm-9:58 am

2 stops41h 28m

$845

ManchesterSantiago

MHT - SCL

MHTSCL

Manchester

Sat 12/6

2:32 pm-8:50 am

2 stops40h 18m

Santiago Arturo Merino Benitez

Tue 12/9

10:45 pm-6:49 pm

2 stops22h 04m

$846

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Manchester, New Hampshire to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Manchester, New Hampshire to South America is on a Tuesday when prices can be found for as low as $802. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Manchester, New Hampshire to South America for around $1,041.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Manchester, New Hampshire to South America flights are usually those with departure times in the afternoon. Our users have found flights to South America in the afternoon for as low as $796. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $895 on average. Flights to South America from Manchester, New Hampshire in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Manchester, New Hampshire to South America flights?

You could potentially save up to 7% on your flight if you consider stops on a Manchester, New Hampshire to South America flight.

Cheap Manchester, New Hampshire to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to South America

Best Price Found

$664

Fastest flight time

12h 25m

Direct flights

None

Airports in South America

9 airports
The best one-way flight to South America from Manchester, New Hampshire in the past 72 hours is $664. The best round-trip flight deal from Manchester, New Hampshire to South America found on momondo in the last 72 hours is $475.
The fastest flight from Manchester, New Hampshire to South America takes 12h 25m
There are no direct flights from Manchester, New Hampshire to South America. Popular non-direct routes for this connection are Manchester Airport - Rio de Janeiro–Galeão Intl Airport, Manchester Airport - Porto Alegre Salgado Filho Airport and Manchester Airport - Pereira Matecana Airport.
There are 9 airports near South America: Guayaquil Jose Joaquin de Olmedo (GYE), Porto Alegre Salgado Filho (POA), Rio de Janeiro–Galeão Intl (GIG), Pereira Matecana (PEI), Cartagena Rafael Nunez (CTG), Montevideo Carrasco (MVD), Sao Paulo Guarulhos Intl (GRU), Santiago Arturo Merino Benitez (SCL), Medellín Jose Maria Cordova Intl (MDE)
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  • When did momondo last update prices for flights from Manchester Airport to South America?

    Prices for flights from Manchester Airport to South America were last updated today.

  • How old do you have to be to fly from Manchester Airport to South America?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Manchester Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to South America?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Manchester to South America. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Manchester to South America with flexible booking policies on momondo?

All flight searches from Manchester to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Manchester to South America?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Manchester to South America.

I’m not ready to book a flight from Manchester to South America right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Manchester to South America flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Find better results for your trip to South America

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