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Cheap flights from Madison to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Madison to Knoxville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Madison to Knoxville

Cheap round-trip flights

Delta Logo
5:40 am - 1:07 pmMSN-TYS
6h 27m1 stop
Delta Logo
6:40 am - 11:25 amTYS-MSN
5h 45m1 stop
$249Delta
Find Deal
Fri, Oct 3 - Tue, Oct 7
American Airlines Logo
2:48 pm - 9:41 pmMSN-TYS
5h 53m1 stop
American Airlines Logo
8:36 pm - 12:19 amTYS-MSN
4h 43m1 stop
$259American Airlines
Find Deal
Wed, Sep 3 - Sun, Sep 7
American Airlines Logo
8:00 am - 5:13 pmMSN-TYS
8h 13m2 stops
American Airlines Logo
8:36 pm - 12:19 amTYS-MSN
4h 43m1 stop
$264American Airlines
Find Deal
Wed, Sep 3 - Sun, Sep 7
American Airlines Logo
12:46 pm - 7:46 pmMSN-TYS
6h 00m1 stop
American Airlines Logo
8:37 pm - 11:51 pmTYS-MSN
4h 14m1 stop
$279American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
American Airlines Logo
5:46 pm - 12:23 amMSN-TYS
5h 37m1 stop
American Airlines Logo
7:20 pm - 11:30 pmTYS-MSN
5h 10m1 stop
$329American Airlines
Find Deal
Wed, Oct 29 - Mon, Nov 3
American Airlines Logo
8:00 am - 4:49 pmMSN-TYS
7h 49m2 stops
American Airlines Logo
7:00 am - 12:04 pmTYS-MSN
6h 04m1 stop
$334American Airlines
Find Deal
Sat, Oct 4 - Sat, Oct 18
Delta Logo
5:40 am - 1:07 pmMSN-TYS
6h 27m1 stop
Delta Logo
6:08 pm - 10:58 pmTYS-MSN
5h 50m1 stop
$377Delta
Find Deal
Sun, Sep 21 - Fri, Sep 26
United Airlines Logo
10:50 am - 5:00 pmMSN-TYS
5h 10m1 stop
United Airlines Logo
7:00 am - 9:45 amTYS-MSN
3h 45m1 stop
$403United Airlines
Find Deal
Wed, Sep 3 - Sun, Sep 7
United Airlines Logo
10:50 am - 7:53 pmMSN-TYS
8h 03m2 stops
United Airlines Logo
7:00 am - 9:45 amTYS-MSN
3h 45m1 stop
$408United Airlines
Find Deal
Wed, Sep 3 - Sun, Sep 7
Frontier Logo
6:47 pm - 7:32 pmMSN-TYS
23h 45m1 stop
Frontier Logo
7:17 pm - 7:15 pmTYS-MSN
24h 58m1 stop
$427Frontier
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Sun, Oct 26 - Sun, Nov 2

Delta flights from Madison to Knoxville

Our best Delta deals on Madison to Knoxville flight tickets
Delta
Oct 3
MSN5:40 amMadison Truax Field
6h 27m
1 stop
TYS1:07 pmKnoxville McGhee Tyson
Oct 7
TYS6:40 amKnoxville McGhee Tyson
5h 45m
1 stop
MSN11:25 amMadison Truax Field
$249
Find similar
Delta
Sep 21
MSN5:40 amMadison Truax Field
6h 27m
1 stop
TYS1:07 pmKnoxville McGhee Tyson
Sep 26
TYS6:08 pmKnoxville McGhee Tyson
5h 50m
1 stop
MSN10:58 pmMadison Truax Field
$377
Find similar
Delta
Aug 25
MSN5:40 amMadison Truax Field
4h 02m
1 stop
TYS10:42 amKnoxville McGhee Tyson
Aug 29
TYS6:14 pmKnoxville McGhee Tyson
5h 48m
1 stop
MSN11:02 pmMadison Truax Field
$677
Find similar

American Airlines flights from Madison to Knoxville

Our best American Airlines deals on Madison to Knoxville flight tickets
American Airlines
Sep 3
MSN2:48 pmMadison Truax Field
5h 53m
1 stop
TYS9:41 pmKnoxville McGhee Tyson
Sep 7
TYS8:36 pmKnoxville McGhee Tyson
4h 43m
1 stop
MSN12:19 amMadison Truax Field
$259
Find similar
American Airlines
Sep 3
MSN8:00 amMadison Truax Field
8h 13m
2 stops
TYS5:13 pmKnoxville McGhee Tyson
Sep 7
TYS8:36 pmKnoxville McGhee Tyson
4h 43m
1 stop
MSN12:19 amMadison Truax Field
$264
Find similar
American Airlines
Oct 2
MSN12:46 pmMadison Truax Field
6h 00m
1 stop
TYS7:46 pmKnoxville McGhee Tyson
Oct 6
TYS8:37 pmKnoxville McGhee Tyson
4h 14m
1 stop
MSN11:51 pmMadison Truax Field
$279
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Madison to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Madison to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Fri 10/3

5:40 am-1:07 pm

1 stop6h 27m

Knoxville McGhee Tyson

Tue 10/7

6:40 am-11:25 am

1 stop5h 45m

$249

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Wed 9/3

2:48 pm-9:41 pm

1 stop5h 53m

Knoxville McGhee Tyson

Sun 9/7

8:36 pm-12:19 am

1 stop4h 43m

$259

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Wed 9/3

8:00 am-5:13 pm

2 stops8h 13m

Knoxville McGhee Tyson

Sun 9/7

8:36 pm-12:19 am

1 stop4h 43m

$264

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Thu 10/2

12:46 pm-7:46 pm

1 stop6h 00m

Knoxville McGhee Tyson

Mon 10/6

8:37 pm-11:51 pm

1 stop4h 14m

$279

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Wed 10/29

5:46 pm-12:23 am

1 stop5h 37m

Knoxville McGhee Tyson

Mon 11/3

7:20 pm-11:30 pm

1 stop5h 10m

$329

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Sat 10/4

8:00 am-4:49 pm

2 stops7h 49m

Knoxville McGhee Tyson

Sat 10/18

7:00 am-12:04 pm

1 stop6h 04m

$334

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Sun 9/21

5:40 am-1:07 pm

1 stop6h 27m

Knoxville McGhee Tyson

Fri 9/26

6:08 pm-10:58 pm

1 stop5h 50m

$377

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Wed 9/3

10:50 am-5:00 pm

1 stop5h 10m

Knoxville McGhee Tyson

Sun 9/7

7:00 am-9:45 am

1 stop3h 45m

$403

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Wed 9/3

10:50 am-7:53 pm

2 stops8h 03m

Knoxville McGhee Tyson

Sun 9/7

7:00 am-9:45 am

1 stop3h 45m

$408

MadisonKnoxville

MSN - TYS

MSNTYS

Madison Truax Field

Sun 10/26

6:47 pm-7:32 pm

1 stop23h 45m

Knoxville McGhee Tyson

Sun 11/2

7:17 pm-7:15 pm

1 stop24h 58m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Madison to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Madison, with most prices found around $313. If you aren’t able to travel during the month of October, then book flights to Knoxville from Madison during August instead. Flights to Knoxville in August, while not as cheap as those in October, still average around $338.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Madison to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $343. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Madison to Knoxville for around $468.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Madison to Knoxville when you can find flight prices for as low as $363. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $410.

When to book flights from Madison to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Madison to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Madison to Knoxville (MSN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Madison to Knoxville

Direct flights

None
There are no direct flights from Madison to Knoxville. There are no popular flight routes from Madison to Knoxville.
Search flight deals

  • How far is Madison Truax Field to Knoxville McGhee Tyson by plane?

    There are 571.0 mi between Madison Truax Field and Knoxville McGhee Tyson. A reasonable flight in good conditions will take 3h 35m.

  • When did momondo last update prices for flights from Madison Truax Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Madison Truax Field Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Madison Truax Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Madison Truax Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Madison Truax Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Madison to Knoxville?

Best airlines flying from Madison to Knoxville

Compare and see reviews for airlines that fly from Madison to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $172Free CancellationRating
7.9
7,982 reviews
Search Delta flights
American AirlinesPriceFrom $208Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Madison to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Madison to Knoxville for you.

Can I find flights from Madison to Knoxville with flexible booking policies on momondo?

Flights from Madison to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Madison to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Madison to Knoxville.

I’m not ready to book a flight from Madison to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Madison to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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