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Cheap flights from Louisville to South Carolina from $44

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to South Carolina departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Louisville to South Carolina

Cheap round-trip flights

Breeze Airways Logo
8:52 pm - 10:28 pmSDF-CHS
1h 36mnonstop
Breeze Airways Logo
7:05 am - 8:58 amCHS-SDF
1h 53mnonstop
$114Breeze Airways
Find Deal
Fri, Oct 17 - Mon, Oct 20
Breeze Airways Logo
8:52 pm - 10:28 pmSDF-CHS
1h 36mnonstop
Breeze Airways Logo
7:05 am - 8:58 amCHS-SDF
1h 53mnonstop
$118Breeze Airways
Find Deal
Fri, Oct 24 - Mon, Oct 27
Spirit Airlines Logo
10:55 am - 10:45 amSDF-CHS
23h 50m1 stop
Spirit Airlines Logo
5:40 pm - 9:59 amCHS-SDF
16h 19m1 stop
$190Spirit Airlines
Find Deal
Sun, Nov 9 - Mon, Nov 17
Spirit Airlines Logo
10:55 am - 10:45 amSDF-CHS
23h 50m1 stop
Spirit Airlines Logo
5:40 pm - 9:59 amCHS-SDF
16h 19m1 stop
$204Spirit Airlines
Find Deal
Sat, Nov 8 - Mon, Nov 17
Southwest Logo
5:30 am - 10:00 amSDF-SAV
4h 30m1 stop
Southwest Logo
8:45 am - 1:00 pmSAV-SDF
4h 15m1 stop
$217Southwest
Find Deal
Wed, Oct 22 - Wed, Oct 29
Southwest Logo
3:50 pm - 8:20 pmSDF-SAV
4h 30m1 stop
Southwest Logo
1:50 pm - 10:45 pmSAV-SDF
8h 55m2 stops
$222Southwest
Find Deal
Wed, Oct 22 - Wed, Oct 29
American Airlines Logo
8:22 am - 2:32 pmSDF-HHH
6h 10m1 stop
American Airlines Logo
6:48 pm - 12:22 amHHH-SDF
5h 34m1 stop
$229American Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 15
American Airlines Logo
7:26 am - 5:27 pmSDF-HHH
10h 01m2 stops
American Airlines Logo
6:48 pm - 12:22 amHHH-SDF
5h 34m1 stop
$234American Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 15
Delta Logo
6:00 am - 9:28 amSDF-CAE
3h 28m1 stop
Delta Logo
10:10 am - 1:50 pmCAE-SDF
3h 40m1 stop
$264Delta
Find Deal
Sat, Mar 7 - Tue, Mar 10
Delta Logo
5:58 pm - 11:58 pmSDF-SAV
6h 00m1 stop
Delta Logo
5:40 am - 8:54 amSAV-SDF
3h 14m1 stop
$265Delta
Find Deal
Mon, Oct 20 - Mon, Oct 27

Spirit Airlines flights from Louisville to South Carolina

Our best Spirit Airlines deals on Louisville to South Carolina flight tickets
Spirit Airlines
Nov 9
SDF10:55 amLouisville Intl
23h 50m
1 stop
CHS10:45 amCharleston
Nov 17
CHS5:40 pmCharleston
16h 19m
1 stop
SDF9:59 amLouisville Intl
$190
Find similar
Spirit Airlines
Nov 8
SDF10:55 amLouisville Intl
23h 50m
1 stop
CHS10:45 amCharleston
Nov 17
CHS5:40 pmCharleston
16h 19m
1 stop
SDF9:59 amLouisville Intl
$204
Find similar
Spirit Airlines
Oct 18
SDF6:58 pmLouisville Intl
14h 08m
1 stop
CHS9:06 amCharleston
Oct 23
CHS10:11 amCharleston
7h 52m
1 stop
SDF6:03 pmLouisville Intl
$215
Find similar

American Airlines flights from Louisville to South Carolina

Our best American Airlines deals on Louisville to South Carolina flight tickets
American Airlines
Nov 1
SDF8:22 amLouisville Intl
6h 10m
1 stop
HHH2:32 pmHilton Head Island
Nov 15
HHH6:48 pmHilton Head Island
5h 34m
1 stop
SDF12:22 amLouisville Intl
$229
Find similar
American Airlines
Nov 1
SDF7:26 amLouisville Intl
10h 01m
2 stops
HHH5:27 pmHilton Head Island
Nov 15
HHH6:48 pmHilton Head Island
5h 34m
1 stop
SDF12:22 amLouisville Intl
$234
Find similar
American Airlines
Nov 1
SDF7:26 amLouisville Intl
10h 01m
2 stops
HHH5:27 pmHilton Head Island
Nov 15
HHH2:51 pmHilton Head Island
8h 04m
2 stops
SDF10:55 pmLouisville Intl
$239
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 24, 2025.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 10/17

8:52 pm-10:28 pm

Nonstop1h 36m

Charleston

Mon 10/20

7:05 am-8:58 am

Nonstop1h 53m

$114

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 10/24

8:52 pm-10:28 pm

Nonstop1h 36m

Charleston

Mon 10/27

7:05 am-8:58 am

Nonstop1h 53m

$118

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Sun 11/9

10:55 am-10:45 am

1 stop23h 50m

Charleston

Mon 11/17

5:40 pm-9:59 am

1 stop16h 19m

$190

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Sat 11/8

10:55 am-10:45 am

1 stop23h 50m

Charleston

Mon 11/17

5:40 pm-9:59 am

1 stop16h 19m

$204

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Wed 10/22

5:30 am-10:00 am

1 stop4h 30m

Savannah/Hilton Head

Wed 10/29

8:45 am-1:00 pm

1 stop4h 15m

$217

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Wed 10/22

3:50 pm-8:20 pm

1 stop4h 30m

Savannah/Hilton Head

Wed 10/29

1:50 pm-10:45 pm

2 stops8h 55m

$222

LouisvilleHilton Head Island

SDF - HHH

SDFHHH

Louisville Intl

Sat 11/1

8:22 am-2:32 pm

1 stop6h 10m

Hilton Head Island

Sat 11/15

6:48 pm-12:22 am

1 stop5h 34m

$229

LouisvilleHilton Head Island

SDF - HHH

SDFHHH

Louisville Intl

Sat 11/1

7:26 am-5:27 pm

2 stops10h 01m

Hilton Head Island

Sat 11/15

6:48 pm-12:22 am

1 stop5h 34m

$234

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Sat 3/7

6:00 am-9:28 am

1 stop3h 28m

Columbia Metropolitan

Tue 3/10

10:10 am-1:50 pm

1 stop3h 40m

$264

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Mon 10/20

5:58 pm-11:58 pm

1 stop6h 00m

Savannah/Hilton Head

Mon 10/27

5:40 am-8:54 am

1 stop3h 14m

$265

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Louisville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Louisville is in August. Flight prices, which tend to average around $176, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Louisville during September instead. Flights to South Carolina in September, while not as cheap as those in August, still average around $179.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $130. The most expensive day to fly to South Carolina is Wednesday, with ticket prices averaging around $204.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Louisville to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $131. Try not to purchase tickets in the afternoon because they tend to be around $322. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Louisville Intl to South Carolina flight route?

Fly from Louisville Intl to Myrtle Beach Intl for the best Louisville Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Louisville when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $278 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Louisville for as low as $219 on momondo.

What cabin class options are available on Louisville Intl to South Carolina flights?

There is only 1 cabin class available to choose from on Louisville Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Louisville to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Louisville to South Carolina.

Cheap Louisville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to South Carolina

Best Price Found

$66

Fastest flight time

1h 31m

Direct flights

Every day

Airports in South Carolina

2 airports
The best one-way flight to South Carolina from Louisville in the past 72 hours is $66. The best round-trip flight deal from Louisville to South Carolina found on momondo in the last 72 hours is $106.
The fastest flight from Louisville to South Carolina takes 1h 31m
Direct flights go from Louisville to South Carolina every day.
There are 2 airports near South Carolina: Charlotte Douglas (CLT), Charleston (CHS)
Search flight deals

  • When did momondo last update prices for flights from Louisville Intl Airport to South Carolina?

    Prices for flights from Louisville Intl Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Louisville Intl Airport to South Carolina?

  • How old do you have to be to fly from Louisville Intl Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Louisville to South Carolina?

Best airlines flying from Louisville to South Carolina

Compare and see reviews for airlines that fly from Louisville to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $77Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
Spirit AirlinesPriceFrom $87Free CancellationRating
6.3
8,042 reviews
Search Spirit Airlines flights
Breeze AirwaysPriceFrom $88Free CancellationRating
8.0
208 reviews
Search Breeze Airways flights
United AirlinesPriceFrom $148Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
DeltaPriceFrom $149Free CancellationRating
7.9
7,973 reviews
Search Delta flights
American AirlinesPriceFrom $190Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $219Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Louisville to South Carolina for you.

Can I find flights from Louisville to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Louisville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Louisville to South Carolina?

Once you have performed a search for Louisville to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Louisville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Louisville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Fri 10/24
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