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Cheap flights from Louisville to South Carolina from $55

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to South Carolina departing on 12/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Breeze Airways Logo
8:28 pm - 10:06 pm
SDF
-
CHS
1h 38mnonstop
Breeze Airways Logo
7:00 am - 8:46 am
CHS
-
SDF
1h 46mnonstop
$124Breeze Airways
Fri, Jun 5 - Mon, Jun 8
Multiple Airlines Logo
8:52 pm - 10:28 pm
SDF
-
CHS
1h 36mnonstop
Multiple Airlines Logo
6:35 pm - 2:41 pm
CHS
-
SDF
20h 06m1 stop
$131Multiple Airlines
Mon, Jan 5 - Mon, Jan 12
American Airlines Logo
8:00 am - 2:25 pm
SDF
-
SAV
6h 25m1 stop
American Airlines Logo
4:27 pm - 10:14 pm
SAV
-
SDF
5h 47m1 stop
$236American Airlines
Wed, Dec 24 - Thu, Jan 1
Delta Logo
6:00 am - 9:45 am
SDF
-
CAE
3h 45m1 stop
Delta Logo
5:35 am - 9:28 am
CAE
-
SDF
3h 53m1 stop
$239Delta
Thu, Jan 1 - Tue, Jan 13
Spirit Airlines Logo
7:00 am - 7:20 pm
SDF
-
MYR
12h 20m1 stop
Spirit Airlines Logo
1:07 pm - 1:00 pm
MYR
-
SDF
23h 53m1 stop
$256Spirit Airlines
Thu, Jan 8 - Thu, Jan 15
Delta Logo
5:35 am - 9:46 am
SDF
-
MYR
4h 11m1 stop
Delta Logo
6:00 am - 9:26 am
MYR
-
SDF
3h 26m1 stop
$257Delta
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
6:03 am - 11:50 am
SDF
-
MYR
5h 47m1 stop
American Airlines Logo
1:53 pm - 10:05 pm
MYR
-
SDF
8h 12m2 stops
$262American Airlines
Sat, Jan 31 - Wed, Feb 4
Spirit Airlines Logo
7:00 am - 7:20 pm
SDF
-
MYR
12h 20m1 stop
Spirit Airlines Logo
8:15 pm - 1:00 pm
MYR
-
SDF
16h 45m2 stops
$264Spirit Airlines
Thu, Jan 8 - Thu, Jan 15
Southwest Logo
5:30 am - 9:55 am
SDF
-
MYR
4h 25m1 stop
Southwest Logo
11:05 am - 4:50 pm
MYR
-
SDF
5h 45m1 stop
$278Southwest
Thu, Feb 12 - Wed, Feb 18
Southwest Logo
5:30 am - 9:55 am
SDF
-
MYR
4h 25m1 stop
Southwest Logo
3:00 pm - 10:45 pm
MYR
-
SDF
7h 45m2 stops
$283Southwest
Thu, Feb 12 - Wed, Feb 18

American Airlines flights from Louisville to South Carolina

Our best American Airlines deals on Louisville to South Carolina flight tickets
American Airlines
Dec 24
SDF8:00 amLouisville Intl
6h 25m
1 stop
SAV2:25 pmSavannah/Hilton Head
Jan 1
SAV4:27 pmSavannah/Hilton Head
5h 47m
1 stop
SDF10:14 pmLouisville Intl
$236
Find similar
American Airlines
Jan 10
SDF5:26 pmLouisville Intl
14h 05m
1 stop
CLT7:31 amCharlotte Douglas
Jan 11
CLT10:50 amCharlotte Douglas
1h 35m
SDF12:25 pmLouisville Intl
$242
Find similar
American Airlines
Jan 9
SDF4:32 pmLouisville Intl
6h 35m
2 stops
CHS11:07 pmCharleston
Jan 12
CHS6:10 amCharleston
6h 22m
2 stops
SDF12:32 pmLouisville Intl
$247
Find similar

Delta flights from Louisville to South Carolina

Our best Delta deals on Louisville to South Carolina flight tickets
Delta
Jan 9
SDF3:37 pmLouisville Intl
5h 18m
1 stop
CHS8:55 pmCharleston
Jan 12
CHS2:44 pmCharleston
6h 12m
1 stop
SDF8:56 pmLouisville Intl
$237
Find similar
Delta
Jan 1
SDF6:00 amLouisville Intl
3h 45m
1 stop
CAE9:45 amColumbia Metropolitan
Jan 13
CAE5:35 amColumbia Metropolitan
3h 53m
1 stop
SDF9:28 amLouisville Intl
$239
Find similar
Delta
Feb 3
SDF5:35 amLouisville Intl
3h 51m
1 stop
CHS9:26 amCharleston
Feb 10
CHS3:02 pmCharleston
6h 03m
1 stop
SDF9:05 pmLouisville Intl
$257
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 13, 2025.
Use the filters below to find and compare flights from Louisville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Fri 6/5

8:28 pm-10:06 pm

Nonstop1h 38m

Charleston

Mon 6/8

7:00 am-8:46 am

Nonstop1h 46m

$124

LouisvilleCharleston

SDF - CHS

SDFCHS

Louisville Intl

Mon 1/5

8:52 pm-10:28 pm

Nonstop1h 36m

Charleston

Mon 1/12

6:35 pm-2:41 pm

1 stop20h 06m

$131

LouisvilleSavannah

SDF - SAV

SDFSAV

Louisville Intl

Wed 12/24

8:00 am-2:25 pm

1 stop6h 25m

Savannah/Hilton Head

Thu 1/1

4:27 pm-10:14 pm

1 stop5h 47m

$236

LouisvilleColumbia

SDF - CAE

SDFCAE

Louisville Intl

Thu 1/1

6:00 am-9:45 am

1 stop3h 45m

Columbia Metropolitan

Tue 1/13

5:35 am-9:28 am

1 stop3h 53m

$239

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Thu 1/8

7:00 am-7:20 pm

1 stop12h 20m

Myrtle Beach Intl

Thu 1/15

1:07 pm-1:00 pm

1 stop23h 53m

$256

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Sat 1/31

5:35 am-9:46 am

1 stop4h 11m

Myrtle Beach Intl

Wed 2/4

6:00 am-9:26 am

1 stop3h 26m

$257

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Sat 1/31

6:03 am-11:50 am

1 stop5h 47m

Myrtle Beach Intl

Wed 2/4

1:53 pm-10:05 pm

2 stops8h 12m

$262

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Thu 1/8

7:00 am-7:20 pm

1 stop12h 20m

Myrtle Beach Intl

Thu 1/15

8:15 pm-1:00 pm

2 stops16h 45m

$264

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Thu 2/12

5:30 am-9:55 am

1 stop4h 25m

Myrtle Beach Intl

Wed 2/18

11:05 am-4:50 pm

1 stop5h 45m

$278

LouisvilleMyrtle Beach

SDF - MYR

SDFMYR

Louisville Intl

Thu 2/12

5:30 am-9:55 am

1 stop4h 25m

Myrtle Beach Intl

Wed 2/18

3:00 pm-10:45 pm

2 stops7h 45m

$283

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Louisville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Louisville is in September. Flight prices, which tend to average around $150, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Louisville during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $176.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $122. The most expensive day to fly to South Carolina is Wednesday, with ticket prices averaging around $204.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Louisville to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $127. Try not to purchase tickets in the afternoon because they tend to be around $322. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Louisville Intl to South Carolina flight route?

Fly from Louisville Intl to Myrtle Beach Intl for the best Louisville Intl - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Louisville when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $258 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Louisville for as low as $206 on momondo.

What cabin class options are available on Louisville Intl to South Carolina flights?

There is only 1 cabin class available to choose from on Louisville Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Louisville to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Louisville to South Carolina.

Cheap Louisville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to South Carolina

Best Price Found

$128

Fastest flight time

1h 35m

Direct flights

Mon, Tue, Wed, Thu, Sat and Sun

Airports in South Carolina

57 airports
The best flight deal from Louisville to South Carolina found on momondo in the last 72 hours is $128
The fastest flight from Louisville to South Carolina takes 1h 35m
Direct flights go from Louisville to South Carolina on Monday, Tuesday, Wednesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Louisville there are direct flights to Charlotte Douglas (CLT), Charleston (CHS).
Search flight deals

  • When did momondo last update prices for flights from Louisville Intl Airport to South Carolina?

    Prices for flights from Louisville Intl Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Louisville Intl Airport to South Carolina?

  • How old do you have to be to fly from Louisville Intl Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The necessary travel and health documents for your South Carolina trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Louisville to South Carolina?

Best airlines flying from Louisville to South Carolina

Compare and see reviews for airlines that fly from Louisville to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $77Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
Spirit AirlinesPriceFrom $86Free CancellationRating
6.3
8,181 reviews
Search Spirit Airlines flights
Breeze AirwaysPriceFrom $88Free CancellationRating
8.2
247 reviews
Search Breeze Airways flights
DeltaPriceFrom $137Free CancellationRating
7.9
8,009 reviews
Search Delta flights
United AirlinesPriceFrom $148Free CancellationRating
7.4
9,096 reviews
Search United Airlines flights
American AirlinesPriceFrom $190Free CancellationRating
7.2
11,052 reviews
Search American Airlines flights
SouthwestPriceFrom $219Free CancellationRating
8.0
4,254 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Louisville to South Carolina for you.

Can I find flights from Louisville to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Louisville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Louisville to South Carolina?

Once you have performed a search for Louisville to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Louisville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Louisville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

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