Cheap flights from Los Angeles to South America from $145

In general, September is the cheapest month to fly from Los Angeles to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $724. If you aren’t able to travel during the month of September, then book flights to South America from Los Angeles during March instead. Flights to South America in March, while not as cheap as those in September, still average around $743.

The cheapest day to depart from Los Angeles to South America is on a Wednesday when prices can be found for as low as $890. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Los Angeles to South America for around $990.

Our data shows that the cheapest Los Angeles to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $903. If you have a flexible travel schedule, then try to avoid flying in the evening when prices are $970 on average. Flights to South America from Los Angeles in the evening are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Los Angeles to Santiago Arturo Merino Benitez for the best Los Angeles - South America flight prices

You are more likely to see cheaper flights to South America from Los Angeles when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $792 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Los Angeles for as low as $743 on momondo.

There are 4 cabin classes available to choose from on Los Angeles to South America flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

United Airlines, Delta, and Copa Airlines are the most popular carriers operating from Los Angeles to South America

LATAM Airlines, Copa Airlines and Avianca are the top three most popular airlines that fly to South America from Los Angeles according to our data. LATAM Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 11 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

8 flights are operational daily from Los Angeles to South America as of April 2026. The most popular departure time for this route is 11:00AM, with 47% of flights per day taking off at noon.

As of April 2026, 61 flights take off from Los Angeles and land in South America each week. The most common flight departure day for this route is Mon, with 21% of weekly flights taking off on this day.