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Cheap flights from Knoxville to Myrtle Beach from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Myrtle Beach departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:25 pm - 8:36 pm
TYS
-
MYR
28h 11m
1 stop
Multiple Airlines Logo
3:17 pm - 2:56 pm
MYR
-
TYS
23h 39m
1 stop
$245Multiple Airlines
Wed, May 13 - Wed, May 20
Multiple Airlines Logo
1:02 pm - 8:36 pm
TYS
-
MYR
7h 34m
1 stop
Multiple Airlines Logo
3:17 pm - 12:11 pm
MYR
-
TYS
20h 54m
1 stop
$250Multiple Airlines
Wed, Jun 3 - Wed, Jun 10
Multiple Airlines Logo
3:35 pm - 11:29 pm
TYS
-
MYR
7h 54m
1 stop
Multiple Airlines Logo
11:52 am - 8:42 pm
MYR
-
TYS
8h 50m
1 stop
$252Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
3:35 pm - 11:29 pm
TYS
-
MYR
7h 54m
1 stop
Multiple Airlines Logo
11:52 am - 8:42 pm
MYR
-
TYS
8h 50m
1 stop
$262Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
4:25 pm - 8:11 am
TYS
-
MYR
15h 46m
1 stop
Multiple Airlines Logo
6:55 pm - 1:09 pm
MYR
-
TYS
18h 14m
1 stop
$270Multiple Airlines
Wed, Apr 29 - Fri, May 1
Multiple Airlines Logo
7:30 am - 2:20 pm
TYS
-
MYR
6h 50m
1 stop
Multiple Airlines Logo
6:00 am - 12:25 pm
MYR
-
TYS
6h 25m
1 stop
$275Multiple Airlines
Mon, May 11 - Mon, May 18
Multiple Airlines Logo
3:35 pm - 11:29 pm
TYS
-
MYR
7h 54m
1 stop
Multiple Airlines Logo
5:01 pm - 9:48 pm
MYR
-
TYS
28h 47m
2 stops
$277Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:30 am - 11:29 pm
TYS
-
MYR
15h 59m
1 stop
Multiple Airlines Logo
6:18 pm - 10:36 am
MYR
-
TYS
40h 18m
2 stops
$282Multiple Airlines
Mon, Apr 27 - Mon, May 4
Multiple Airlines Logo
4:25 pm - 2:48 pm
TYS
-
MYR
22h 23m
2 stops
Multiple Airlines Logo
3:17 pm - 2:56 pm
MYR
-
TYS
23h 39m
1 stop
$286Multiple Airlines
Wed, May 13 - Wed, May 20
Multiple Airlines Logo
3:35 pm - 11:29 pm
TYS
-
MYR
7h 54m
1 stop
Multiple Airlines Logo
9:56 pm - 2:58 pm
MYR
-
TYS
41h 02m
2 stops
$290Multiple Airlines
Thu, Apr 23 - Sun, Apr 26

American Airlines flights from Knoxville to Myrtle Beach

Our best American Airlines deals on Knoxville to Myrtle Beach flight tickets
American Airlines
May 8
TYS5:00 amKnoxville McGhee Tyson
3h 24m
1 stop
MYR8:24 amMyrtle Beach Intl
May 17
MYR5:00 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:32 amKnoxville McGhee Tyson
$337
American Airlines
Apr 23
TYS5:00 amKnoxville McGhee Tyson
3h 24m
1 stop
MYR8:24 amMyrtle Beach Intl
Apr 26
MYR5:00 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:32 amKnoxville McGhee Tyson
$338
American Airlines
Apr 14
TYS5:00 amKnoxville McGhee Tyson
4h 45m
1 stop
MYR9:45 amMyrtle Beach Intl
Apr 30
MYR5:00 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:32 amKnoxville McGhee Tyson
$368

Southwest flights from Knoxville to Myrtle Beach

Our best Southwest deals on Knoxville to Myrtle Beach flight tickets
Southwest
May 13
TYS7:05 amKnoxville McGhee Tyson
8h 20m
2 stops
MYR3:25 pmMyrtle Beach Intl
May 20
MYR7:35 amMyrtle Beach Intl
12h 05m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$315
Southwest
Jun 3
TYS7:05 amKnoxville McGhee Tyson
8h 20m
2 stops
MYR3:25 pmMyrtle Beach Intl
Jun 10
MYR8:30 amMyrtle Beach Intl
11h 50m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
$334
Southwest
Jul 23
TYS6:40 amKnoxville McGhee Tyson
6h 45m
1 stop
MYR1:25 pmMyrtle Beach Intl
Jul 26
MYR5:50 pmMyrtle Beach Intl
3h 25m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
$342

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 5/13

4:25 pm-8:36 pm

1 stop28h 11m

Myrtle Beach Intl

Wed 5/20

3:17 pm-2:56 pm

1 stop23h 39m

$245

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 6/3

1:02 pm-8:36 pm

1 stop7h 34m

Myrtle Beach Intl

Wed 6/10

3:17 pm-12:11 pm

1 stop20h 54m

$250

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-11:29 pm

1 stop7h 54m

Myrtle Beach Intl

Sun 4/26

11:52 am-8:42 pm

1 stop8h 50m

$252

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-11:29 pm

1 stop7h 54m

Myrtle Beach Intl

Sun 4/26

11:52 am-8:42 pm

1 stop8h 50m

$262

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 4/29

4:25 pm-8:11 am

1 stop15h 46m

Myrtle Beach Intl

Fri 5/1

6:55 pm-1:09 pm

1 stop18h 14m

$270
Quickest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 5/11

7:30 am-2:20 pm

1 stop6h 50m

Myrtle Beach Intl

Mon 5/18

6:00 am-12:25 pm

1 stop6h 25m

$275

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-11:29 pm

1 stop7h 54m

Myrtle Beach Intl

Sun 4/26

5:01 pm-9:48 pm

2 stops28h 47m

$277

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 4/27

7:30 am-11:29 pm

1 stop15h 59m

Myrtle Beach Intl

Mon 5/4

6:18 pm-10:36 am

2 stops40h 18m

$282

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 5/13

4:25 pm-2:48 pm

2 stops22h 23m

Myrtle Beach Intl

Wed 5/20

3:17 pm-2:56 pm

1 stop23h 39m

$286

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 4/23

3:35 pm-11:29 pm

1 stop7h 54m

Myrtle Beach Intl

Sun 4/26

9:56 pm-2:58 pm

2 stops41h 02m

$290

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Myrtle Beach?

When to book flights from Knoxville to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Myrtle Beach (TYS to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Myrtle Beach

Fastest flight time

3h 34m

Direct flights

None
The fastest flight from Knoxville to Myrtle Beach takes 3h 34m
There are no direct flights from Knoxville to Myrtle Beach. There are no popular flight routes from Knoxville to Myrtle Beach.
Search flight deals

  • How far is Knoxville McGhee Tyson to Myrtle Beach Intl by plane?

    Knoxville McGhee Tyson and Myrtle Beach Intl are 325.5 mi apart from one another. By plane, this route typically takes 3h 34m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents required for your trip to Myrtle Beach Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Myrtle Beach Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Myrtle Beach?

Best airlines flying from Knoxville to Myrtle Beach

Compare and see reviews for airlines that fly from Knoxville to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $125Free CancellationRating
7.9
8,364 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,543 reviews
Search American Airlines flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Sunset Beach
Ocean Isle Beach
Murrells Inlet
Garden City Beach
Surfside Beach
Conway
Little River
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Myrtle Beach?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Myrtle Beach. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Myrtle Beach with flexible booking policies on momondo?

Flights from Knoxville to Myrtle Beach with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Myrtle Beach?

Once you have performed a search for Knoxville to Myrtle Beach flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Myrtle Beach right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Myrtle Beach now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Myrtle Beach and let you know when they change.

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