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Cheap flights from Knoxville to Myrtle Beach from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Myrtle Beach departing on 7/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:02 pm - 7:37 pm
TYS
-
MYR
26h 35m
1 stop
Multiple Airlines Logo
2:28 pm - 11:34 pm
MYR
-
TYS
9h 06m
1 stop
$283Multiple Airlines
Tue, Jun 9 - Fri, Jun 12
Multiple Airlines Logo
10:54 am - 5:45 pm
TYS
-
MYR
6h 51m
1 stop
Multiple Airlines Logo
6:28 pm - 3:32 pm
MYR
-
TYS
21h 04m
1 stop
$286Multiple Airlines
Thu, Aug 20 - Thu, Sep 3
Multiple Airlines Logo
5:02 pm - 7:37 pm
TYS
-
MYR
26h 35m
1 stop
Multiple Airlines Logo
2:28 pm - 11:34 pm
MYR
-
TYS
9h 06m
1 stop
$288Multiple Airlines
Tue, Jun 9 - Fri, Jun 12
Delta Logo
8:35 am - 1:04 pm
TYS
-
MYR
4h 29m
1 stop
Delta Logo
6:00 am - 9:53 am
MYR
-
TYS
3h 53m
1 stop
$295Delta
Wed, Jun 17 - Wed, Jun 24
Multiple Airlines Logo
3:42 pm - 9:05 am
TYS
-
MYR
17h 23m
1 stop
Multiple Airlines Logo
9:07 pm - 11:12 pm
MYR
-
TYS
26h 05m
1 stop
$299Multiple Airlines
Thu, Jun 25 - Sun, Jun 28
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
Southwest Logo
2:25 pm - 7:50 pm
MYR
-
TYS
5h 25m
1 stop
$300Southwest
Tue, Aug 11 - Tue, Aug 18
Multiple Airlines Logo
12:55 pm - 1:51 pm
TYS
-
MYR
24h 56m
2 stops
Multiple Airlines Logo
6:28 pm - 3:32 pm
MYR
-
TYS
21h 04m
1 stop
$301Multiple Airlines
Thu, Aug 20 - Thu, Sep 3
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
Southwest Logo
8:15 am - 6:55 pm
MYR
-
TYS
10h 40m
2 stops
$305Southwest
Tue, Aug 11 - Tue, Aug 18
Delta Logo
5:45 am - 10:47 am
TYS
-
MYR
5h 02m
1 stop
Delta Logo
6:00 am - 11:11 am
MYR
-
TYS
5h 11m
1 stop
$308Delta
Tue, Aug 4 - Thu, Aug 6
Southwest Logo
8:25 am - 1:50 pm
TYS
-
MYR
5h 25m
1 stop
Southwest Logo
8:15 am - 6:55 pm
MYR
-
TYS
10h 40m
2 stops
$313Southwest
Thu, Sep 10 - Tue, Sep 15

Delta flights from Knoxville to Myrtle Beach

Our best Delta deals on Knoxville to Myrtle Beach flight tickets
Delta
Jun 17
TYS8:35 amKnoxville McGhee Tyson
4h 29m
1 stop
MYR1:04 pmMyrtle Beach Intl
Jun 24
MYR6:00 amMyrtle Beach Intl
3h 53m
1 stop
TYS9:53 amKnoxville McGhee Tyson
$295
Delta
Aug 4
TYS5:45 amKnoxville McGhee Tyson
5h 02m
1 stop
MYR10:47 amMyrtle Beach Intl
Aug 6
MYR6:00 amMyrtle Beach Intl
5h 11m
1 stop
TYS11:11 amKnoxville McGhee Tyson
$308
Delta
Aug 5
TYS5:45 amKnoxville McGhee Tyson
5h 02m
1 stop
MYR10:47 amMyrtle Beach Intl
Aug 7
MYR6:00 amMyrtle Beach Intl
5h 11m
1 stop
TYS11:11 amKnoxville McGhee Tyson
$316

Southwest flights from Knoxville to Myrtle Beach

Our best Southwest deals on Knoxville to Myrtle Beach flight tickets
Southwest
Aug 11
TYS7:00 amKnoxville McGhee Tyson
6h 50m
2 stops
MYR1:50 pmMyrtle Beach Intl
Aug 18
MYR2:25 pmMyrtle Beach Intl
5h 25m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
$300
Southwest
Aug 11
TYS7:00 amKnoxville McGhee Tyson
6h 50m
2 stops
MYR1:50 pmMyrtle Beach Intl
Aug 18
MYR8:15 amMyrtle Beach Intl
10h 40m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$305
Southwest
Jul 7
TYS8:10 amKnoxville McGhee Tyson
10h 15m
1 stop
MYR6:25 pmMyrtle Beach Intl
Jul 10
MYR12:00 pmMyrtle Beach Intl
10h 30m
1 stop
TYS10:30 pmKnoxville McGhee Tyson
$327

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 6/9

5:02 pm-7:37 pm

1 stop26h 35m

Myrtle Beach Intl

Fri 6/12

2:28 pm-11:34 pm

1 stop9h 06m

$283

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 8/20

10:54 am-5:45 pm

1 stop6h 51m

Myrtle Beach Intl

Thu 9/3

6:28 pm-3:32 pm

1 stop21h 04m

$286

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 6/9

5:02 pm-7:37 pm

1 stop26h 35m

Myrtle Beach Intl

Fri 6/12

2:28 pm-11:34 pm

1 stop9h 06m

$288
Quickest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 6/17

8:35 am-1:04 pm

1 stop4h 29m

Myrtle Beach Intl

Wed 6/24

6:00 am-9:53 am

1 stop3h 53m

$295

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 6/25

3:42 pm-9:05 am

1 stop17h 23m

Myrtle Beach Intl

Sun 6/28

9:07 pm-11:12 pm

1 stop26h 05m

$299

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 8/11

7:00 am-1:50 pm

2 stops6h 50m

Myrtle Beach Intl

Tue 8/18

2:25 pm-7:50 pm

1 stop5h 25m

$300

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 8/20

12:55 pm-1:51 pm

2 stops24h 56m

Myrtle Beach Intl

Thu 9/3

6:28 pm-3:32 pm

1 stop21h 04m

$301

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 8/11

7:00 am-1:50 pm

2 stops6h 50m

Myrtle Beach Intl

Tue 8/18

8:15 am-6:55 pm

2 stops10h 40m

$305

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 8/4

5:45 am-10:47 am

1 stop5h 02m

Myrtle Beach Intl

Thu 8/6

6:00 am-11:11 am

1 stop5h 11m

$308

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 9/10

8:25 am-1:50 pm

1 stop5h 25m

Myrtle Beach Intl

Tue 9/15

8:15 am-6:55 pm

2 stops10h 40m

$313

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Knoxville to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Myrtle Beach?

What is the cheapest month to fly to Myrtle Beach?

In general, January is the cheapest month to fly from Knoxville to Myrtle Beach. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you are unable to visit Myrtle Beach during the month of January, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $256.

When to book flights from Knoxville to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Myrtle Beach (TYS to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Myrtle Beach

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Knoxville to Myrtle Beach takes 4h 25m
There are no direct flights from Knoxville to Myrtle Beach. There are no popular flight routes from Knoxville to Myrtle Beach.
Search flight deals

Frequently asked questions about flying from Knoxville to Myrtle Beach

  • How far is Knoxville McGhee Tyson to Myrtle Beach Intl by plane?

    Knoxville McGhee Tyson and Myrtle Beach Intl are 325.5 mi apart from one another. By plane, this route typically takes 4h 25m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents required for your trip to Myrtle Beach Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Myrtle Beach Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Myrtle Beach?

Best airlines flying from Knoxville to Myrtle Beach

Compare and see reviews for airlines that fly from Knoxville to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,642 reviews
Search American Airlines flights
DeltaPriceFrom $238Free CancellationRating
7.9
8,454 reviews
Search Delta flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Ocean Isle Beach
Sunset Beach
Murrells Inlet
Surfside Beach
Garden City Beach
Conway
Little River
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Myrtle Beach?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Myrtle Beach. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Myrtle Beach with flexible booking policies on momondo?

Flights from Knoxville to Myrtle Beach with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Myrtle Beach?

Once you have performed a search for Knoxville to Myrtle Beach flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Myrtle Beach right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Myrtle Beach now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Myrtle Beach and let you know when they change.

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