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Cheap flights from Knoxville to Myrtle Beach from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Myrtle Beach departing on 3/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:30 am - 12:25 pm
TYS
-
MYR
5h 55m
1 stop
Multiple Airlines Logo
9:53 am - 11:02 am
MYR
-
TYS
25h 09m
1 stop
$223Multiple Airlines
Thu, Mar 5 - Sat, Mar 7
Multiple Airlines Logo
6:30 am - 12:25 pm
TYS
-
MYR
5h 55m
1 stop
Multiple Airlines Logo
9:09 am - 10:10 am
MYR
-
TYS
25h 01m
1 stop
$230Multiple Airlines
Thu, Mar 5 - Mon, Mar 9
Multiple Airlines Logo
2:05 pm - 11:44 am
TYS
-
MYR
21h 39m
1 stop
Multiple Airlines Logo
9:53 am - 11:02 am
MYR
-
TYS
25h 09m
1 stop
$240Multiple Airlines
Wed, Mar 4 - Sat, Mar 7
Multiple Airlines Logo
9:08 pm - 8:13 am
TYS
-
MYR
11h 05m
1 stop
Multiple Airlines Logo
1:20 pm - 12:02 pm
MYR
-
TYS
22h 42m
1 stop
$245Multiple Airlines
Sat, Feb 28 - Wed, Mar 4
Multiple Airlines Logo
2:05 pm - 11:44 am
TYS
-
MYR
21h 39m
1 stop
Multiple Airlines Logo
9:09 am - 10:10 am
MYR
-
TYS
25h 01m
1 stop
$247Multiple Airlines
Wed, Mar 4 - Mon, Mar 9
Multiple Airlines Logo
6:30 am - 12:25 pm
TYS
-
MYR
5h 55m
1 stop
Multiple Airlines Logo
12:39 pm - 11:01 am
MYR
-
TYS
22h 22m
2 stops
$250Multiple Airlines
Thu, Mar 5 - Sun, Mar 8
Multiple Airlines Logo
6:30 am - 12:25 pm
TYS
-
MYR
5h 55m
1 stop
Multiple Airlines Logo
9:54 pm - 10:26 pm
MYR
-
TYS
24h 32m
2 stops
$254Multiple Airlines
Thu, Mar 5 - Sat, Mar 7
Multiple Airlines Logo
9:36 pm - 8:13 am
TYS
-
MYR
10h 37m
1 stop
Multiple Airlines Logo
9:09 am - 10:10 am
MYR
-
TYS
25h 01m
1 stop
$256Multiple Airlines
Fri, Feb 27 - Tue, Mar 3
Multiple Airlines Logo
11:50 am - 2:40 pm
TYS
-
MYR
26h 50m
2 stops
Multiple Airlines Logo
9:09 am - 8:57 pm
MYR
-
TYS
11h 48m
1 stop
$261Multiple Airlines
Sun, Mar 1 - Thu, Mar 5
Multiple Airlines Logo
4:25 pm - 5:33 pm
TYS
-
MYR
25h 08m
1 stop
Multiple Airlines Logo
6:28 pm - 10:26 pm
MYR
-
TYS
27h 58m
1 stop
$264Multiple Airlines
Wed, Mar 11 - Wed, Mar 18

Delta flights from Knoxville to Myrtle Beach

Our best Delta deals on Knoxville to Myrtle Beach flight tickets
Delta
Mar 4
TYS5:35 amKnoxville McGhee Tyson
4h 10m
1 stop
MYR9:45 amMyrtle Beach Intl
Mar 11
MYR6:00 amMyrtle Beach Intl
3h 16m
1 stop
TYS9:16 amKnoxville McGhee Tyson
$279
Delta
Mar 9
TYS6:38 pmKnoxville McGhee Tyson
5h 26m
1 stop
MYR12:04 amMyrtle Beach Intl
Mar 11
MYR6:00 amMyrtle Beach Intl
5h 17m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$309
Delta
May 27
TYS7:35 amKnoxville McGhee Tyson
5h 13m
1 stop
MYR12:48 pmMyrtle Beach Intl
May 30
MYR6:00 amMyrtle Beach Intl
5h 12m
1 stop
TYS11:12 amKnoxville McGhee Tyson
$312

American Airlines flights from Knoxville to Myrtle Beach

Our best American Airlines deals on Knoxville to Myrtle Beach flight tickets
American Airlines
May 9
TYS5:00 amKnoxville McGhee Tyson
3h 21m
1 stop
MYR8:21 amMyrtle Beach Intl
May 16
MYR5:00 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:32 amKnoxville McGhee Tyson
$298
American Airlines
Mar 9
TYS5:47 pmKnoxville McGhee Tyson
6h 08m
1 stop
MYR11:55 pmMyrtle Beach Intl
Mar 12
MYR5:10 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:42 amKnoxville McGhee Tyson
$339
American Airlines
Feb 22
TYS8:24 amKnoxville McGhee Tyson
6h 03m
1 stop
MYR2:27 pmMyrtle Beach Intl
Mar 1
MYR5:10 amMyrtle Beach Intl
3h 32m
1 stop
TYS8:42 amKnoxville McGhee Tyson
$487

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 3/5

6:30 am-12:25 pm

1 stop5h 55m

Myrtle Beach Intl

Sat 3/7

9:53 am-11:02 am

1 stop25h 09m

$223

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 3/5

6:30 am-12:25 pm

1 stop5h 55m

Myrtle Beach Intl

Mon 3/9

9:09 am-10:10 am

1 stop25h 01m

$230

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-11:44 am

1 stop21h 39m

Myrtle Beach Intl

Sat 3/7

9:53 am-11:02 am

1 stop25h 09m

$240

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 2/28

9:08 pm-8:13 am

1 stop11h 05m

Myrtle Beach Intl

Wed 3/4

1:20 pm-12:02 pm

1 stop22h 42m

$245

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-11:44 am

1 stop21h 39m

Myrtle Beach Intl

Mon 3/9

9:09 am-10:10 am

1 stop25h 01m

$247

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 3/5

6:30 am-12:25 pm

1 stop5h 55m

Myrtle Beach Intl

Sun 3/8

12:39 pm-11:01 am

2 stops22h 22m

$250

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 3/5

6:30 am-12:25 pm

1 stop5h 55m

Myrtle Beach Intl

Sat 3/7

9:54 pm-10:26 pm

2 stops24h 32m

$254

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 2/27

9:36 pm-8:13 am

1 stop10h 37m

Myrtle Beach Intl

Tue 3/3

9:09 am-10:10 am

1 stop25h 01m

$256

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sun 3/1

11:50 am-2:40 pm

2 stops26h 50m

Myrtle Beach Intl

Thu 3/5

9:09 am-8:57 pm

1 stop11h 48m

$261

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 3/11

4:25 pm-5:33 pm

1 stop25h 08m

Myrtle Beach Intl

Wed 3/18

6:28 pm-10:26 pm

1 stop27h 58m

$264

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Knoxville to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Myrtle Beach Intl?

Delta is the most popular carrier operating from Knoxville McGhee Tyson to Myrtle Beach Intl

When to book flights from Knoxville to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Myrtle Beach (TYS to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Myrtle Beach

Fastest flight time

4h 39m

Direct flights

None
The fastest flight from Knoxville to Myrtle Beach takes 4h 39m
There are no direct flights from Knoxville to Myrtle Beach. There are no popular flight routes from Knoxville to Myrtle Beach.
Search flight deals

  • How far is Knoxville McGhee Tyson to Myrtle Beach Intl by plane?

    Knoxville McGhee Tyson and Myrtle Beach Intl are 325.5 mi apart from one another. By plane, this route typically takes 4h 39m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents required for your trip to Myrtle Beach Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Myrtle Beach Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Myrtle Beach?

Best airlines flying from Knoxville to Myrtle Beach

Compare and see reviews for airlines that fly from Knoxville to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $125Free CancellationRating
7.9
8,203 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,288 reviews
Search American Airlines flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Sunset Beach
Ocean Isle Beach
Murrells Inlet
Garden City Beach
Surfside Beach
Conway
Little River
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Myrtle Beach?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Myrtle Beach. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Myrtle Beach with flexible booking policies on momondo?

Flights from Knoxville to Myrtle Beach with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Myrtle Beach?

Once you have performed a search for Knoxville to Myrtle Beach flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Myrtle Beach right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Myrtle Beach now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Myrtle Beach and let you know when they change.

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