Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Myrtle Beach from $124

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Myrtle Beach departing on 8/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:25 pm - 10:38 pm
TYS
-
MYR
3h 13m
1 stop
American Airlines Logo
5:27 pm - 8:58 pm
MYR
-
TYS
3h 31m
1 stop
$211American Airlines
Sat, Aug 22 - Sat, Aug 29
Delta Logo
6:12 pm - 11:30 pm
TYS
-
MYR
5h 18m
1 stop
Delta Logo
6:00 am - 9:36 am
MYR
-
TYS
3h 36m
1 stop
$237Delta
Mon, Aug 10 - Mon, Aug 17
Delta Logo
5:00 pm - 9:49 pm
TYS
-
MYR
4h 49m
1 stop
Delta Logo
6:00 am - 9:33 am
MYR
-
TYS
3h 33m
1 stop
$255Delta
Sat, Aug 15 - Sat, Aug 22
Southwest Logo
2:55 pm - 6:10 pm
TYS
-
MYR
3h 15m
1 stop
Southwest Logo
8:40 am - 9:00 pm
MYR
-
TYS
12h 20m
2 stops
$266Southwest
Sat, Oct 10 - Tue, Oct 13
American Airlines Logo
4:22 pm - 8:59 pm
TYS
-
MYR
4h 37m
1 stop
American Airlines Logo
5:15 pm - 8:59 pm
MYR
-
TYS
3h 44m
1 stop
$268American Airlines
Wed, Aug 5 - Thu, Aug 6
American Airlines Logo
4:22 pm - 9:10 pm
TYS
-
MYR
4h 48m
1 stop
American Airlines Logo
12:14 pm - 5:34 pm
MYR
-
TYS
5h 20m
1 stop
$274American Airlines
Sat, Aug 8 - Fri, Aug 14
Multiple Airlines Logo
8:00 am - 7:37 pm
TYS
-
MYR
11h 37m
2 stops
Multiple Airlines Logo
9:07 pm - 12:51 pm
MYR
-
TYS
15h 44m
1 stop
$276Multiple Airlines
Wed, Aug 5 - Thu, Aug 6
Southwest Logo
7:10 am - 7:40 pm
TYS
-
MYR
12h 30m
2 stops
Southwest Logo
2:30 pm - 6:35 pm
MYR
-
TYS
4h 05m
1 stop
$279Southwest
Mon, Aug 10 - Thu, Aug 13
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
Southwest Logo
6:40 am - 6:35 pm
MYR
-
TYS
11h 55m
2 stops
$284Southwest
Wed, Aug 5 - Thu, Aug 6
Multiple Airlines Logo
12:56 pm - 7:37 pm
TYS
-
MYR
6h 41m
1 stop
Multiple Airlines Logo
9:07 pm - 11:31 pm
MYR
-
TYS
26h 24m
1 stop
$285Multiple Airlines
Wed, Aug 5 - Sun, Aug 9

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from Knoxville to Myrtle Beach

Our best Delta deals on Knoxville to Myrtle Beach flight tickets
Delta
Aug 10
TYS6:12 pmKnoxville McGhee Tyson
5h 18m
1 stop
MYR11:30 pmMyrtle Beach Intl
Aug 17
MYR6:00 amMyrtle Beach Intl
3h 36m
1 stop
TYS9:36 amKnoxville McGhee Tyson
$237
Delta
Aug 15
TYS5:00 pmKnoxville McGhee Tyson
4h 49m
1 stop
MYR9:49 pmMyrtle Beach Intl
Aug 22
MYR6:00 amMyrtle Beach Intl
3h 33m
1 stop
TYS9:33 amKnoxville McGhee Tyson
$255

Southwest flights from Knoxville to Myrtle Beach

Our best Southwest deals on Knoxville to Myrtle Beach flight tickets
Southwest
Oct 10
TYS2:55 pmKnoxville McGhee Tyson
3h 15m
1 stop
MYR6:10 pmMyrtle Beach Intl
Oct 13
MYR8:40 amMyrtle Beach Intl
12h 20m
2 stops
TYS9:00 pmKnoxville McGhee Tyson
$266
Southwest
Aug 10
TYS7:10 amKnoxville McGhee Tyson
12h 30m
2 stops
MYR7:40 pmMyrtle Beach Intl
Aug 13
MYR2:30 pmMyrtle Beach Intl
4h 05m
1 stop
TYS6:35 pmKnoxville McGhee Tyson
$279
Southwest
Aug 5
TYS7:00 amKnoxville McGhee Tyson
6h 50m
2 stops
MYR1:50 pmMyrtle Beach Intl
Aug 6
MYR6:40 amMyrtle Beach Intl
11h 55m
2 stops
TYS6:35 pmKnoxville McGhee Tyson
$284

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 8/22

7:25 pm-10:38 pm

1 stop3h 13m

Myrtle Beach Intl

Sat 8/29

5:27 pm-8:58 pm

1 stop3h 31m

$211

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 8/10

6:12 pm-11:30 pm

1 stop5h 18m

Myrtle Beach Intl

Mon 8/17

6:00 am-9:36 am

1 stop3h 36m

$237

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 8/15

5:00 pm-9:49 pm

1 stop4h 49m

Myrtle Beach Intl

Sat 8/22

6:00 am-9:33 am

1 stop3h 33m

$255

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 10/10

2:55 pm-6:10 pm

1 stop3h 15m

Myrtle Beach Intl

Tue 10/13

8:40 am-9:00 pm

2 stops12h 20m

$266

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 8/5

4:22 pm-8:59 pm

1 stop4h 37m

Myrtle Beach Intl

Thu 8/6

5:15 pm-8:59 pm

1 stop3h 44m

$268

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 8/8

4:22 pm-9:10 pm

1 stop4h 48m

Myrtle Beach Intl

Fri 8/14

12:14 pm-5:34 pm

1 stop5h 20m

$274

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 8/5

8:00 am-7:37 pm

2 stops11h 37m

Myrtle Beach Intl

Thu 8/6

9:07 pm-12:51 pm

1 stop15h 44m

$276

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 8/10

7:10 am-7:40 pm

2 stops12h 30m

Myrtle Beach Intl

Thu 8/13

2:30 pm-6:35 pm

1 stop4h 05m

$279

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 8/5

7:00 am-1:50 pm

2 stops6h 50m

Myrtle Beach Intl

Thu 8/6

6:40 am-6:35 pm

2 stops11h 55m

$284

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 8/5

12:56 pm-7:37 pm

1 stop6h 41m

Myrtle Beach Intl

Sun 8/9

9:07 pm-11:31 pm

1 stop26h 24m

$285

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Knoxville to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Myrtle Beach?

What is the cheapest month to fly to Myrtle Beach?

In general, January is the cheapest month to fly from Knoxville to Myrtle Beach. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you are unable to visit Myrtle Beach during the month of January, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $278.

When to book flights from Knoxville to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Myrtle Beach (TYS to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Myrtle Beach

Fastest flight time

4h 47m

Direct flights

None
The fastest flight from Knoxville to Myrtle Beach takes 4h 47m
There are no direct flights from Knoxville to Myrtle Beach. There are no popular flight routes from Knoxville to Myrtle Beach.
Search flight deals

Frequently asked questions about flying from Knoxville to Myrtle Beach

  • How far is Knoxville McGhee Tyson to Myrtle Beach Intl by plane?

    Knoxville McGhee Tyson and Myrtle Beach Intl are 325.5 mi apart from one another. By plane, this route typically takes 4h 47m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents required for your trip to Myrtle Beach Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Myrtle Beach Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Knoxville to Myrtle Beach?

Best airlines flying from Knoxville to Myrtle Beach

Compare and see reviews for airlines that fly from Knoxville to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $224Free CancellationRating
7.1
11,782 reviews
Search American Airlines flights
DeltaPriceFrom $238Free CancellationRating
7.8
8,452 reviews
Search Delta flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Ocean Isle Beach
Surfside Beach
Sunset Beach
Murrells Inlet
Conway
Garden City Beach
Georgetown
Little River

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Myrtle Beach?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Myrtle Beach. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Myrtle Beach with flexible booking policies on momondo?

Flights from Knoxville to Myrtle Beach with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Myrtle Beach?

Once you have performed a search for Knoxville to Myrtle Beach flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Myrtle Beach right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Myrtle Beach now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Myrtle Beach and let you know when they change.

An easier way to manage your Myrtle Beach trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 8/5
Wed 8/12
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States