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Cheap flights from Knoxville to Boston from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 4/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:30 am - 5:29 pm
TYS
-
MHT
8h 59m
1 stop
Multiple Airlines Logo
11:23 am - 6:21 pm
MHT
-
TYS
30h 58m
2 stops
$387Multiple Airlines
Wed, Apr 1 - Sun, Apr 5
Southwest Logo
7:30 am - 4:20 pm
TYS
-
MHT
8h 50m
1 stop
Southwest Logo
12:30 pm - 10:30 pm
MHT
-
TYS
10h 00m
2 stops
$388Southwest
Thu, Jul 9 - Mon, Jul 13
Southwest Logo
12:15 pm - 11:30 pm
TYS
-
MHT
11h 15m
2 stops
Southwest Logo
3:55 pm - 8:45 pm
MHT
-
TYS
4h 50m
1 stop
$392Southwest
Thu, May 21 - Sun, May 24
Southwest Logo
12:15 pm - 11:30 pm
TYS
-
MHT
11h 15m
2 stops
Southwest Logo
6:00 am - 5:25 pm
MHT
-
TYS
11h 25m
2 stops
$397Southwest
Thu, May 21 - Sun, May 24
Southwest Logo
7:30 am - 4:20 pm
TYS
-
MHT
8h 50m
1 stop
Southwest Logo
1:30 pm - 10:30 pm
MHT
-
TYS
9h 00m
1 stop
$398Southwest
Thu, Jul 9 - Mon, Jul 13
United Airlines Logo
9:40 am - 1:55 pm
TYS
-
MHT
4h 15m
1 stop
United Airlines Logo
2:30 pm - 7:42 pm
MHT
-
TYS
5h 12m
1 stop
$401United Airlines
Wed, Apr 8 - Sat, Apr 11
Southwest Logo
12:35 pm - 12:05 am
TYS
-
MHT
11h 30m
2 stops
Southwest Logo
12:30 pm - 10:30 pm
MHT
-
TYS
10h 00m
2 stops
$407Southwest
Thu, Jul 9 - Mon, Jul 13
United Airlines Logo
9:40 am - 1:55 pm
TYS
-
MHT
4h 15m
1 stop
United Airlines Logo
2:30 pm - 7:42 pm
MHT
-
TYS
5h 12m
1 stop
$411United Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
5:57 pm - 12:21 am
TYS
-
MHT
6h 24m
1 stop
American Airlines Logo
5:44 am - 11:01 am
MHT
-
TYS
5h 17m
1 stop
$417American Airlines
Fri, Apr 10 - Sun, Apr 12
Southwest Logo
7:30 am - 4:20 pm
TYS
-
MHT
8h 50m
1 stop
Southwest Logo
5:35 am - 3:45 pm
MHT
-
TYS
10h 10m
2 stops
$418Southwest
Mon, Jul 20 - Fri, Jul 24

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Apr 10
TYS5:57 pmKnoxville McGhee Tyson
6h 24m
1 stop
MHT12:21 amManchester
Apr 12
MHT5:44 amManchester
5h 17m
1 stop
TYS11:01 amKnoxville McGhee Tyson
$417
American Airlines
Apr 1
TYS6:05 amKnoxville McGhee Tyson
5h 30m
1 stop
MHT11:35 amManchester
Apr 5
MHT5:30 amManchester
5h 28m
1 stop
TYS10:58 amKnoxville McGhee Tyson
$477
American Airlines
Mar 21
TYS6:38 pmKnoxville McGhee Tyson
4h 20m
1 stop
MHT10:58 pmManchester
Mar 24
MHT6:13 amManchester
5h 44m
1 stop
TYS11:57 amKnoxville McGhee Tyson
$557

Southwest flights from Knoxville to Manchester, New Hampshire

Our best Southwest deals on Knoxville to Manchester, New Hampshire flight tickets
Southwest
Jul 9
TYS7:30 amKnoxville McGhee Tyson
8h 50m
1 stop
MHT4:20 pmManchester
Jul 13
MHT12:30 pmManchester
10h 00m
2 stops
TYS10:30 pmKnoxville McGhee Tyson
$388
Southwest
May 21
TYS12:15 pmKnoxville McGhee Tyson
11h 15m
2 stops
MHT11:30 pmManchester
May 24
MHT3:55 pmManchester
4h 50m
1 stop
TYS8:45 pmKnoxville McGhee Tyson
$392
Southwest
May 21
TYS12:15 pmKnoxville McGhee Tyson
11h 15m
2 stops
MHT11:30 pmManchester
May 24
MHT6:00 amManchester
11h 25m
2 stops
TYS5:25 pmKnoxville McGhee Tyson
$397

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 4/1

8:30 am-5:29 pm

1 stop8h 59m

Manchester

Sun 4/5

11:23 am-6:21 pm

2 stops30h 58m

$387

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 7/9

7:30 am-4:20 pm

1 stop8h 50m

Manchester

Mon 7/13

12:30 pm-10:30 pm

2 stops10h 00m

$388

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 5/21

12:15 pm-11:30 pm

2 stops11h 15m

Manchester

Sun 5/24

3:55 pm-8:45 pm

1 stop4h 50m

$392

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 5/21

12:15 pm-11:30 pm

2 stops11h 15m

Manchester

Sun 5/24

6:00 am-5:25 pm

2 stops11h 25m

$397

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 7/9

7:30 am-4:20 pm

1 stop8h 50m

Manchester

Mon 7/13

1:30 pm-10:30 pm

1 stop9h 00m

$398
Quickest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 4/8

9:40 am-1:55 pm

1 stop4h 15m

Manchester

Sat 4/11

2:30 pm-7:42 pm

1 stop5h 12m

$401

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 7/9

12:35 pm-12:05 am

2 stops11h 30m

Manchester

Mon 7/13

12:30 pm-10:30 pm

2 stops10h 00m

$407

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 4/8

9:40 am-1:55 pm

1 stop4h 15m

Manchester

Sat 4/11

2:30 pm-7:42 pm

1 stop5h 12m

$411

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 4/10

5:57 pm-12:21 am

1 stop6h 24m

Manchester

Sun 4/12

5:44 am-11:01 am

1 stop5h 17m

$417

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 7/20

7:30 am-4:20 pm

1 stop8h 50m

Manchester

Fri 7/24

5:35 am-3:45 pm

2 stops10h 10m

$418

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Boston from

How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of February, then book flights to Manchester, New Hampshire from Knoxville during January instead. Flights to Manchester, New Hampshire in January, while not as cheap as those in February, still average around $340.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Fastest flight time

4h 11m

Direct flights

None
The fastest flight from Knoxville to Manchester, New Hampshire takes 4h 11m
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 4h 11m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,480 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,450 reviews
Search United Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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