Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Boston from $179

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:22 pm - 11:34 pmTYS-MHT
7h 12m1 stop
American Airlines Logo
8:15 am - 12:57 pmMHT-TYS
4h 42m1 stop
$355American Airlines
Find Deal
Mon, Dec 22 - Wed, Dec 31
American Airlines Logo
5:42 am - 11:11 amTYS-MHT
5h 29m1 stop
American Airlines Logo
6:00 am - 4:07 pmMHT-TYS
10h 07m2 stops
$360American Airlines
Find Deal
Mon, Dec 22 - Wed, Dec 31
United Airlines Logo
10:16 am - 3:03 pmTYS-MHT
4h 47m1 stop
United Airlines Logo
6:45 pm - 11:59 pmMHT-TYS
5h 14m1 stop
$423United Airlines
Find Deal
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
6:25 pm - 10:56 pmTYS-MHT
4h 31m1 stop
American Airlines Logo
4:15 pm - 8:43 pmMHT-TYS
4h 28m1 stop
$425American Airlines
Find Deal
Sat, Dec 20 - Mon, Dec 29
American Airlines Logo
5:42 am - 11:11 amTYS-MHT
5h 29m1 stop
American Airlines Logo
4:15 pm - 8:43 pmMHT-TYS
4h 28m1 stop
$427American Airlines
Find Deal
Sun, Dec 21 - Mon, Dec 29
United Airlines Logo
7:00 am - 3:03 pmTYS-MHT
8h 03m2 stops
United Airlines Logo
6:45 pm - 11:59 pmMHT-TYS
5h 14m1 stop
$428United Airlines
Find Deal
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
5:42 am - 11:11 amTYS-MHT
5h 29m1 stop
American Airlines Logo
6:03 am - 2:21 pmMHT-TYS
8h 18m2 stops
$430American Airlines
Find Deal
Sat, Dec 20 - Thu, Jan 1
American Airlines Logo
5:40 pm - 12:45 amTYS-MHT
7h 05m1 stop
American Airlines Logo
6:03 am - 2:21 pmMHT-TYS
8h 18m2 stops
$432American Airlines
Find Deal
Sun, Dec 21 - Thu, Jan 1
Multiple Airlines Logo
5:38 pm - 6:56 pmTYS-MHT
25h 18m1 stop
Multiple Airlines Logo
7:36 pm - 6:59 pmMHT-TYS
23h 23m2 stops
$442Multiple Airlines
Find Deal
Fri, Dec 19 - Wed, Dec 31
United Airlines Logo
7:20 pm - 11:44 pmTYS-MHT
4h 24m1 stop
United Airlines Logo
9:30 am - 2:43 pmMHT-TYS
5h 13m1 stop
$452United Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 16

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Dec 22
TYS4:22 pmKnoxville McGhee Tyson
7h 12m
1 stop
MHT11:34 pmManchester
Dec 31
MHT8:15 amManchester
4h 42m
1 stop
TYS12:57 pmKnoxville McGhee Tyson
$355
Find similar
American Airlines
Dec 22
TYS5:42 amKnoxville McGhee Tyson
5h 29m
1 stop
MHT11:11 amManchester
Dec 31
MHT6:00 amManchester
10h 07m
2 stops
TYS4:07 pmKnoxville McGhee Tyson
$360
Find similar
American Airlines
Dec 20
TYS6:25 pmKnoxville McGhee Tyson
4h 31m
1 stop
MHT10:56 pmManchester
Dec 29
MHT4:15 pmManchester
4h 28m
1 stop
TYS8:43 pmKnoxville McGhee Tyson
$425
Find similar

United Airlines flights from Knoxville to Manchester, New Hampshire

Our best United Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
United Airlines
Apr 11
TYS10:16 amKnoxville McGhee Tyson
4h 47m
1 stop
MHT3:03 pmManchester
Apr 15
MHT6:45 pmManchester
5h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$423
Find similar
United Airlines
Nov 1
TYS7:20 pmKnoxville McGhee Tyson
4h 24m
1 stop
MHT11:44 pmManchester
Nov 5
MHT2:27 pmManchester
5h 53m
1 stop
TYS8:20 pmKnoxville McGhee Tyson
$427
Find similar
United Airlines
Apr 11
TYS7:00 amKnoxville McGhee Tyson
8h 03m
2 stops
MHT3:03 pmManchester
Apr 15
MHT6:45 pmManchester
5h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$428
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 12/22

4:22 pm-11:34 pm

1 stop7h 12m

Manchester

Wed 12/31

8:15 am-12:57 pm

1 stop4h 42m

$355

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 12/22

5:42 am-11:11 am

1 stop5h 29m

Manchester

Wed 12/31

6:00 am-4:07 pm

2 stops10h 07m

$360

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 4/11

10:16 am-3:03 pm

1 stop4h 47m

Manchester

Wed 4/15

6:45 pm-11:59 pm

1 stop5h 14m

$423

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 12/20

6:25 pm-10:56 pm

1 stop4h 31m

Manchester

Mon 12/29

4:15 pm-8:43 pm

1 stop4h 28m

$425

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sun 12/21

5:42 am-11:11 am

1 stop5h 29m

Manchester

Mon 12/29

4:15 pm-8:43 pm

1 stop4h 28m

$427

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 4/11

7:00 am-3:03 pm

2 stops8h 03m

Manchester

Wed 4/15

6:45 pm-11:59 pm

1 stop5h 14m

$428

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 12/20

5:42 am-11:11 am

1 stop5h 29m

Manchester

Thu 1/1

6:03 am-2:21 pm

2 stops8h 18m

$430

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sun 12/21

5:40 pm-12:45 am

1 stop7h 05m

Manchester

Thu 1/1

6:03 am-2:21 pm

2 stops8h 18m

$432

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 12/19

5:38 pm-6:56 pm

1 stop25h 18m

Manchester

Wed 12/31

7:36 pm-6:59 pm

2 stops23h 23m

$442

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 11/12

7:20 pm-11:44 pm

1 stop4h 24m

Manchester

Sun 11/16

9:30 am-2:43 pm

1 stop5h 13m

$452

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Boston from

How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Tuesday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $483. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Wednesday is $648.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is in the evening. Flights from Knoxville to Manchester, New Hampshire during this time can be as low as $448. Flights in the morning are often more expensive with an average ticket price of $609.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Direct flights

None
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 3h 57m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $250Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
American AirlinesPriceFrom $253Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Manchester, New Hampshire trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 11/29
Sat 12/6
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States