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Cheap flights from Knoxville to Boston from $179

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 3/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
2:21 pm - 1:58 pm
TYS
-
MHT
23h 37m
1 stop
United Airlines Logo
7:28 pm - 3:15 pm
MHT
-
TYS
19h 47m
1 stop
$394United Airlines
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
2:17 pm - 11:50 pm
TYS
-
MHT
9h 33m
1 stop
American Airlines Logo
5:33 am - 9:38 pm
MHT
-
TYS
16h 05m
1 stop
$427American Airlines
Wed, Feb 11 - Sun, Feb 15
American Airlines Logo
6:05 am - 3:38 pm
TYS
-
MHT
9h 33m
2 stops
American Airlines Logo
4:00 pm - 9:38 pm
MHT
-
TYS
5h 38m
1 stop
$457American Airlines
Wed, Feb 11 - Sun, Feb 15
United Airlines Logo
10:55 am - 1:58 pm
TYS
-
MHT
27h 03m
2 stops
United Airlines Logo
7:28 pm - 3:15 pm
MHT
-
TYS
19h 47m
1 stop
$484United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
1:50 pm - 1:58 pm
TYS
-
MHT
24h 08m
2 stops
United Airlines Logo
7:28 pm - 10:49 am
MHT
-
TYS
15h 21m
1 stop
$485United Airlines
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
7:54 am - 3:38 pm
TYS
-
MHT
7h 44m
2 stops
American Airlines Logo
12:05 pm - 8:40 pm
MHT
-
TYS
8h 35m
2 stops
$549American Airlines
Wed, Feb 11 - Sun, Feb 15
American Airlines Logo
7:11 pm - 11:46 pm
TYS
-
MHT
4h 35m
1 stop
American Airlines Logo
4:06 pm - 8:56 pm
MHT
-
TYS
4h 50m
1 stop
$567American Airlines
Mon, Feb 9 - Tue, Feb 10
American Airlines Logo
6:00 am - 11:35 am
TYS
-
MHT
5h 35m
1 stop
American Airlines Logo
6:00 am - 3:20 pm
MHT
-
TYS
9h 20m
2 stops
$572American Airlines
Mon, Feb 9 - Tue, Feb 10
American Airlines Logo
4:00 pm - 11:50 pm
TYS
-
MHT
7h 50m
2 stops
American Airlines Logo
5:30 am - 1:54 pm
MHT
-
TYS
8h 24m
2 stops
$577American Airlines
Mon, Feb 9 - Tue, Feb 10
United Airlines Logo
9:40 am - 1:58 pm
TYS
-
MHT
4h 18m
1 stop
United Airlines Logo
2:33 pm - 7:29 pm
MHT
-
TYS
4h 56m
1 stop
$658United Airlines
Thu, Feb 12 - Mon, Feb 16

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Feb 11
TYS2:17 pmKnoxville McGhee Tyson
9h 33m
1 stop
MHT11:50 pmManchester
Feb 15
MHT5:33 amManchester
16h 05m
1 stop
TYS9:38 pmKnoxville McGhee Tyson
$427
American Airlines
Feb 11
TYS6:05 amKnoxville McGhee Tyson
9h 33m
2 stops
MHT3:38 pmManchester
Feb 15
MHT4:00 pmManchester
5h 38m
1 stop
TYS9:38 pmKnoxville McGhee Tyson
$457
American Airlines
Feb 11
TYS7:54 amKnoxville McGhee Tyson
7h 44m
2 stops
MHT3:38 pmManchester
Feb 15
MHT12:05 pmManchester
8h 35m
2 stops
TYS8:40 pmKnoxville McGhee Tyson
$549

United Airlines flights from Knoxville to Manchester, New Hampshire

Our best United Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
United Airlines
Feb 14
TYS2:21 pmKnoxville McGhee Tyson
23h 37m
1 stop
MHT1:58 pmManchester
Feb 18
MHT7:28 pmManchester
19h 47m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
$394
United Airlines
Feb 14
TYS10:55 amKnoxville McGhee Tyson
27h 03m
2 stops
MHT1:58 pmManchester
Feb 18
MHT7:28 pmManchester
19h 47m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
$484
United Airlines
Feb 14
TYS1:50 pmKnoxville McGhee Tyson
24h 08m
2 stops
MHT1:58 pmManchester
Feb 18
MHT7:28 pmManchester
15h 21m
1 stop
TYS10:49 amKnoxville McGhee Tyson
$485

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 2/14

2:21 pm-1:58 pm

1 stop23h 37m

Manchester

Wed 2/18

7:28 pm-3:15 pm

1 stop19h 47m

$394

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 2/11

2:17 pm-11:50 pm

1 stop9h 33m

Manchester

Sun 2/15

5:33 am-9:38 pm

1 stop16h 05m

$427

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 2/11

6:05 am-3:38 pm

2 stops9h 33m

Manchester

Sun 2/15

4:00 pm-9:38 pm

1 stop5h 38m

$457

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 2/14

10:55 am-1:58 pm

2 stops27h 03m

Manchester

Wed 2/18

7:28 pm-3:15 pm

1 stop19h 47m

$484

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 2/14

1:50 pm-1:58 pm

2 stops24h 08m

Manchester

Wed 2/18

7:28 pm-10:49 am

1 stop15h 21m

$485

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 2/11

7:54 am-3:38 pm

2 stops7h 44m

Manchester

Sun 2/15

12:05 pm-8:40 pm

2 stops8h 35m

$549

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 2/9

7:11 pm-11:46 pm

1 stop4h 35m

Manchester

Tue 2/10

4:06 pm-8:56 pm

1 stop4h 50m

$567

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 2/9

6:00 am-11:35 am

1 stop5h 35m

Manchester

Tue 2/10

6:00 am-3:20 pm

2 stops9h 20m

$572

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 2/9

4:00 pm-11:50 pm

2 stops7h 50m

Manchester

Tue 2/10

5:30 am-1:54 pm

2 stops8h 24m

$577

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 2/12

9:40 am-1:58 pm

1 stop4h 18m

Manchester

Mon 2/16

2:33 pm-7:29 pm

1 stop4h 56m

$658

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of September, then book flights to Manchester, New Hampshire from Knoxville during February instead. Flights to Manchester, New Hampshire in February, while not as cheap as those in September, still average around $329.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Knoxville to Manchester, New Hampshire takes 4h 15m
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 4h 15m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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