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Cheap flights from Knoxville to Boston from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 5/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
8:15 am - 12:10 pm
TYS
-
MHT
3h 55m
1 stop
Southwest Logo
3:55 pm - 9:15 pm
MHT
-
TYS
5h 20m
1 stop
$311Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
12:50 pm - 10:30 pm
TYS
-
MHT
9h 40m
2 stops
Southwest Logo
3:55 pm - 9:15 pm
MHT
-
TYS
5h 20m
1 stop
$316Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
12:50 pm - 10:30 pm
TYS
-
MHT
9h 40m
2 stops
Southwest Logo
6:55 am - 5:00 pm
MHT
-
TYS
10h 05m
2 stops
$321Southwest
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
6:10 pm - 10:51 pm
TYS
-
MHT
4h 41m
1 stop
American Airlines Logo
5:16 pm - 9:33 pm
MHT
-
TYS
4h 17m
1 stop
$331American Airlines
Tue, Jul 14 - Tue, Jul 21
Southwest Logo
8:10 am - 12:25 pm
TYS
-
MHT
4h 15m
1 stop
Southwest Logo
5:45 am - 5:10 pm
MHT
-
TYS
11h 25m
2 stops
$359Southwest
Tue, Jun 16 - Sun, Jun 21
Southwest Logo
12:45 pm - 10:45 pm
TYS
-
MHT
10h 00m
2 stops
Southwest Logo
5:45 am - 5:10 pm
MHT
-
TYS
11h 25m
2 stops
$364Southwest
Tue, Jun 16 - Sun, Jun 21
American Airlines Logo
6:53 pm - 11:51 pm
TYS
-
MHT
4h 58m
1 stop
American Airlines Logo
5:41 am - 10:48 am
MHT
-
TYS
5h 07m
1 stop
$377American Airlines
Fri, Jun 19 - Sun, Jun 28
Southwest Logo
12:45 pm - 10:45 pm
TYS
-
MHT
10h 00m
2 stops
Southwest Logo
5:10 pm - 10:30 pm
MHT
-
TYS
5h 20m
1 stop
$382Southwest
Tue, Jul 7 - Fri, Jul 10
American Airlines Logo
6:20 pm - 11:46 pm
TYS
-
MHT
5h 26m
1 stop
American Airlines Logo
5:41 am - 10:48 am
MHT
-
TYS
5h 07m
1 stop
$384American Airlines
Mon, Jun 1 - Sun, Jun 7
Southwest Logo
8:00 am - 3:05 pm
TYS
-
MHT
7h 05m
1 stop
Southwest Logo
9:20 am - 9:10 pm
MHT
-
TYS
11h 50m
2 stops
$388Southwest
Sat, Jul 4 - Thu, Jul 9

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Jul 14
TYS6:10 pmKnoxville McGhee Tyson
4h 41m
1 stop
MHT10:51 pmManchester
Jul 21
MHT5:16 pmManchester
4h 17m
1 stop
TYS9:33 pmKnoxville McGhee Tyson
$331
American Airlines
Jun 19
TYS6:53 pmKnoxville McGhee Tyson
4h 58m
1 stop
MHT11:51 pmManchester
Jun 28
MHT5:41 amManchester
5h 07m
1 stop
TYS10:48 amKnoxville McGhee Tyson
$377
American Airlines
Jun 1
TYS6:20 pmKnoxville McGhee Tyson
5h 26m
1 stop
MHT11:46 pmManchester
Jun 7
MHT5:41 amManchester
5h 07m
1 stop
TYS10:48 amKnoxville McGhee Tyson
$384

United Airlines flights from Knoxville to Manchester, New Hampshire

Our best United Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
United Airlines
Sep 1
TYS7:19 pmKnoxville McGhee Tyson
4h 37m
1 stop
MHT11:56 pmManchester
Sep 2
MHT7:38 pmManchester
4h 19m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
$391
United Airlines
Sep 1
TYS7:19 pmKnoxville McGhee Tyson
4h 37m
1 stop
MHT11:56 pmManchester
Sep 2
MHT9:25 amManchester
11h 23m
2 stops
TYS8:48 pmKnoxville McGhee Tyson
$396
United Airlines
Sep 1
TYS6:30 amKnoxville McGhee Tyson
12h 33m
2 stops
MHT7:03 pmManchester
Sep 2
MHT9:25 amManchester
11h 23m
2 stops
TYS8:48 pmKnoxville McGhee Tyson
$401

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 6/2

8:15 am-12:10 pm

1 stop3h 55m

Manchester

Tue 6/9

3:55 pm-9:15 pm

1 stop5h 20m

$311

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 6/2

12:50 pm-10:30 pm

2 stops9h 40m

Manchester

Tue 6/9

3:55 pm-9:15 pm

1 stop5h 20m

$316

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 6/2

12:50 pm-10:30 pm

2 stops9h 40m

Manchester

Tue 6/9

6:55 am-5:00 pm

2 stops10h 05m

$321
Quickest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 7/14

6:10 pm-10:51 pm

1 stop4h 41m

Manchester

Tue 7/21

5:16 pm-9:33 pm

1 stop4h 17m

$331

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 6/16

8:10 am-12:25 pm

1 stop4h 15m

Manchester

Sun 6/21

5:45 am-5:10 pm

2 stops11h 25m

$359

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 6/16

12:45 pm-10:45 pm

2 stops10h 00m

Manchester

Sun 6/21

5:45 am-5:10 pm

2 stops11h 25m

$364

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 6/19

6:53 pm-11:51 pm

1 stop4h 58m

Manchester

Sun 6/28

5:41 am-10:48 am

1 stop5h 07m

$377

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 7/7

12:45 pm-10:45 pm

2 stops10h 00m

Manchester

Fri 7/10

5:10 pm-10:30 pm

1 stop5h 20m

$382

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Mon 6/1

6:20 pm-11:46 pm

1 stop5h 26m

Manchester

Sun 6/7

5:41 am-10:48 am

1 stop5h 07m

$384

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 7/4

8:00 am-3:05 pm

1 stop7h 05m

Manchester

Thu 7/9

9:20 am-9:10 pm

2 stops11h 50m

$388

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Manchester, New Hampshire?

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of September, then book flights to Manchester, New Hampshire from Knoxville during February instead. Flights to Manchester, New Hampshire in February, while not as cheap as those in September, still average around $329.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Fastest flight time

4h 11m

Direct flights

None
The fastest flight from Knoxville to Manchester, New Hampshire takes 4h 11m
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

Frequently asked questions about flying from Knoxville to Manchester, New Hampshire

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 4h 11m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,669 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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