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Cheap flights from Knoxville to Boston from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to Boston (TYS-MHT)

Cheap round-trip flights

United Airlines Logo
5:50 am - 11:28 amTYS-MHT
5h 38m1 stop
United Airlines Logo
9:40 am - 2:42 pmMHT-TYS
5h 02m1 stop
$249United Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
5:50 am - 11:28 amTYS-MHT
5h 38m1 stop
United Airlines Logo
1:15 pm - 10:33 pmMHT-TYS
9h 18m2 stops
$254United Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
United Airlines Logo
2:00 pm - 11:59 pmTYS-MHT
9h 59m2 stops
United Airlines Logo
1:15 pm - 10:33 pmMHT-TYS
9h 18m2 stops
$259United Airlines
Find Deal
Sat, Jan 17 - Sat, Jan 24
American Airlines Logo
5:08 pm - 11:51 pmTYS-MHT
6h 43m1 stop
American Airlines Logo
4:09 pm - 10:51 pmMHT-TYS
6h 42m2 stops
$306American Airlines
Find Deal
Fri, Oct 31 - Wed, Nov 5
American Airlines Logo
6:10 pm - 11:02 pmTYS-MHT
4h 52m1 stop
American Airlines Logo
11:57 am - 5:43 pmMHT-TYS
5h 46m1 stop
$314American Airlines
Find Deal
Thu, Sep 18 - Thu, Sep 25
United Airlines Logo
9:55 am - 2:57 pmTYS-MHT
5h 02m1 stop
United Airlines Logo
9:40 am - 2:40 pmMHT-TYS
5h 00m1 stop
$329United Airlines
Find Deal
Tue, Sep 2 - Sat, Sep 6
American Airlines Logo
12:03 pm - 9:13 pmTYS-MHT
9h 10m2 stops
American Airlines Logo
12:08 pm - 9:00 pmMHT-TYS
8h 52m2 stops
$330American Airlines
Find Deal
Tue, Sep 2 - Sat, Sep 6
United Airlines Logo
9:55 am - 2:57 pmTYS-MHT
5h 02m1 stop
United Airlines Logo
1:30 pm - 10:45 pmMHT-TYS
9h 15m2 stops
$334United Airlines
Find Deal
Tue, Sep 2 - Sat, Sep 6
American Airlines Logo
2:02 pm - 11:51 pmTYS-MHT
9h 49m2 stops
American Airlines Logo
4:09 pm - 10:51 pmMHT-TYS
6h 42m2 stops
$377American Airlines
Find Deal
Fri, Oct 31 - Wed, Nov 5
American Airlines Logo
7:00 am - 11:36 amTYS-MHT
4h 36m1 stop
American Airlines Logo
5:25 pm - 9:33 pmMHT-TYS
4h 08m1 stop
$384American Airlines
Find Deal
Sat, Oct 25 - Mon, Dec 29

United Airlines flights from Knoxville to Manchester, New Hampshire

Our best United Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
United Airlines
Jan 17
TYS5:50 amKnoxville McGhee Tyson
5h 38m
1 stop
MHT11:28 amManchester
Jan 24
MHT9:40 amManchester
5h 02m
1 stop
TYS2:42 pmKnoxville McGhee Tyson
$249
Find similar
United Airlines
Jan 17
TYS5:50 amKnoxville McGhee Tyson
5h 38m
1 stop
MHT11:28 amManchester
Jan 24
MHT1:15 pmManchester
9h 18m
2 stops
TYS10:33 pmKnoxville McGhee Tyson
$254
Find similar
United Airlines
Jan 17
TYS2:00 pmKnoxville McGhee Tyson
9h 59m
2 stops
MHT11:59 pmManchester
Jan 24
MHT1:15 pmManchester
9h 18m
2 stops
TYS10:33 pmKnoxville McGhee Tyson
$259
Find similar

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Aug 27
TYS5:27 pmKnoxville McGhee Tyson
6h 32m
1 stop
MHT11:59 pmManchester
Sep 4
MHT6:00 amManchester
4h 37m
1 stop
TYS10:37 amKnoxville McGhee Tyson
$284
Find similar
American Airlines
Oct 31
TYS5:08 pmKnoxville McGhee Tyson
6h 43m
1 stop
MHT11:51 pmManchester
Nov 5
MHT4:09 pmManchester
6h 42m
2 stops
TYS10:51 pmKnoxville McGhee Tyson
$306
Find similar
American Airlines
Sep 18
TYS6:10 pmKnoxville McGhee Tyson
4h 52m
1 stop
MHT11:02 pmManchester
Sep 25
MHT11:57 amManchester
5h 46m
1 stop
TYS5:43 pmKnoxville McGhee Tyson
$314
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 1/17

5:50 am-11:28 am

1 stop5h 38m

Manchester

Sat 1/24

9:40 am-2:42 pm

1 stop5h 02m

$249

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 1/17

5:50 am-11:28 am

1 stop5h 38m

Manchester

Sat 1/24

1:15 pm-10:33 pm

2 stops9h 18m

$254

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 1/17

2:00 pm-11:59 pm

2 stops9h 59m

Manchester

Sat 1/24

1:15 pm-10:33 pm

2 stops9h 18m

$259

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 10/31

5:08 pm-11:51 pm

1 stop6h 43m

Manchester

Wed 11/5

4:09 pm-10:51 pm

2 stops6h 42m

$306

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Thu 9/18

6:10 pm-11:02 pm

1 stop4h 52m

Manchester

Thu 9/25

11:57 am-5:43 pm

1 stop5h 46m

$314

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 9/2

9:55 am-2:57 pm

1 stop5h 02m

Manchester

Sat 9/6

9:40 am-2:40 pm

1 stop5h 00m

$329

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 9/2

12:03 pm-9:13 pm

2 stops9h 10m

Manchester

Sat 9/6

12:08 pm-9:00 pm

2 stops8h 52m

$330

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 9/2

9:55 am-2:57 pm

1 stop5h 02m

Manchester

Sat 9/6

1:30 pm-10:45 pm

2 stops9h 15m

$334

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 10/31

2:02 pm-11:51 pm

2 stops9h 49m

Manchester

Wed 11/5

4:09 pm-10:51 pm

2 stops6h 42m

$377

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:36 am

1 stop4h 36m

Manchester

Mon 12/29

5:25 pm-9:33 pm

1 stop4h 08m

$384

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Manchester, New Hampshire?

Our data shows that Tuesday is the least expensive day to fly to Manchester, New Hampshire. Tickets to fly out on this day can be as low as $483. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Manchester, New Hampshire on Wednesday is $648.

What is the cheapest time of day to depart on your flight to Manchester, New Hampshire?

Our most recent data shows that the best time of day to fly to Manchester, New Hampshire is in the evening. Flights from Knoxville to Manchester, New Hampshire during this time can be as low as $448. Flights in the morning are often more expensive with an average ticket price of $609.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Direct flights

None
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 4h 24m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $250Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
American AirlinesPriceFrom $253Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Manchester, New Hampshire trip

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