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Cheap flights from Knoxville to Boston from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 10/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:16 pm - 11:58 pm
TYS
-
MHT
5h 42m
1 stop
American Airlines Logo
6:00 am - 12:14 pm
MHT
-
TYS
6h 14m
1 stop
$295American Airlines
Wed, Sep 23 - Wed, Sep 30
American Airlines Logo
6:00 am - 10:07 am
TYS
-
MHT
4h 07m
1 stop
American Airlines Logo
12:09 pm - 7:01 pm
MHT
-
TYS
6h 52m
1 stop
$336American Airlines
Sat, Aug 1 - Wed, Aug 12
Southwest Logo
8:00 am - 2:20 pm
TYS
-
MHT
6h 20m
1 stop
Southwest Logo
12:30 pm - 6:55 pm
MHT
-
TYS
6h 25m
2 stops
$340Southwest
Wed, Sep 23 - Wed, Sep 30
Southwest Logo
8:00 am - 8:15 pm
TYS
-
MHT
12h 15m
2 stops
Southwest Logo
7:45 am - 7:50 pm
MHT
-
TYS
12h 05m
2 stops
$351Southwest
Wed, Sep 23 - Wed, Sep 30
American Airlines Logo
7:17 pm - 11:48 pm
TYS
-
MHT
4h 31m
1 stop
American Airlines Logo
5:10 pm - 10:23 pm
MHT
-
TYS
5h 13m
1 stop
$356American Airlines
Wed, Jul 8 - Sat, Jul 11
Southwest Logo
12:45 pm - 8:15 pm
TYS
-
MHT
7h 30m
1 stop
Southwest Logo
6:30 am - 5:10 pm
MHT
-
TYS
10h 40m
1 stop
$361Southwest
Tue, Aug 4 - Fri, Aug 7
American Airlines Logo
7:16 pm - 11:48 pm
TYS
-
MHT
4h 32m
1 stop
American Airlines Logo
5:38 am - 10:38 am
MHT
-
TYS
5h 00m
1 stop
$376American Airlines
Fri, Jul 24 - Tue, Jul 28
American Airlines Logo
11:16 am - 4:39 pm
TYS
-
MHT
5h 23m
1 stop
American Airlines Logo
6:00 am - 10:46 am
MHT
-
TYS
4h 46m
1 stop
$377American Airlines
Sat, Jul 18 - Sat, Aug 1
Southwest Logo
12:35 pm - 10:00 pm
TYS
-
MHT
9h 25m
2 stops
Southwest Logo
11:25 am - 8:25 pm
MHT
-
TYS
9h 00m
2 stops
$382Southwest
Fri, Jul 24 - Tue, Jul 28
Southwest Logo
12:45 pm - 8:15 pm
TYS
-
MHT
7h 30m
1 stop
Southwest Logo
5:40 am - 5:10 pm
MHT
-
TYS
11h 30m
2 stops
$383Southwest
Tue, Aug 4 - Fri, Aug 7

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American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Sep 23
TYS6:16 pmKnoxville McGhee Tyson
5h 42m
1 stop
MHT11:58 pmManchester
Sep 30
MHT6:00 amManchester
6h 14m
1 stop
TYS12:14 pmKnoxville McGhee Tyson
$295
American Airlines
Aug 1
TYS6:00 amKnoxville McGhee Tyson
4h 07m
1 stop
MHT10:07 amManchester
Aug 12
MHT12:09 pmManchester
6h 52m
1 stop
TYS7:01 pmKnoxville McGhee Tyson
$336
American Airlines
Jul 8
TYS7:17 pmKnoxville McGhee Tyson
4h 31m
1 stop
MHT11:48 pmManchester
Jul 11
MHT5:10 pmManchester
5h 13m
1 stop
TYS10:23 pmKnoxville McGhee Tyson
$356

United Airlines flights from Knoxville to Manchester, New Hampshire

Our best United Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
United Airlines
Jul 17
TYS7:19 pmKnoxville McGhee Tyson
4h 40m
1 stop
MHT11:59 pmManchester
Jul 23
MHT7:37 pmManchester
4h 17m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$465
United Airlines
Jul 8
TYS1:35 pmKnoxville McGhee Tyson
5h 27m
1 stop
MHT7:02 pmManchester
Jul 11
MHT9:25 amManchester
11h 19m
2 stops
TYS8:44 pmKnoxville McGhee Tyson
$481
United Airlines
Aug 13
TYS7:20 pmKnoxville McGhee Tyson
4h 39m
1 stop
MHT11:59 pmManchester
Aug 18
MHT2:46 pmManchester
5h 38m
1 stop
TYS8:24 pmKnoxville McGhee Tyson
$483

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 9/23

6:16 pm-11:58 pm

1 stop5h 42m

Manchester

Wed 9/30

6:00 am-12:14 pm

1 stop6h 14m

$295

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 8/1

6:00 am-10:07 am

1 stop4h 07m

Manchester

Wed 8/12

12:09 pm-7:01 pm

1 stop6h 52m

$336

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 9/23

8:00 am-2:20 pm

1 stop6h 20m

Manchester

Wed 9/30

12:30 pm-6:55 pm

2 stops6h 25m

$340

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 9/23

8:00 am-8:15 pm

2 stops12h 15m

Manchester

Wed 9/30

7:45 am-7:50 pm

2 stops12h 05m

$351

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Wed 7/8

7:17 pm-11:48 pm

1 stop4h 31m

Manchester

Sat 7/11

5:10 pm-10:23 pm

1 stop5h 13m

$356

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 8/4

12:45 pm-8:15 pm

1 stop7h 30m

Manchester

Fri 8/7

6:30 am-5:10 pm

1 stop10h 40m

$361
Quickest round-trip

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 7/24

7:16 pm-11:48 pm

1 stop4h 32m

Manchester

Tue 7/28

5:38 am-10:38 am

1 stop5h 00m

$376

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Sat 7/18

11:16 am-4:39 pm

1 stop5h 23m

Manchester

Sat 8/1

6:00 am-10:46 am

1 stop4h 46m

$377

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Fri 7/24

12:35 pm-10:00 pm

2 stops9h 25m

Manchester

Tue 7/28

11:25 am-8:25 pm

2 stops9h 00m

$382

KnoxvilleManchester

TYS - MHT

TYSMHT

Knoxville McGhee Tyson

Tue 8/4

12:45 pm-8:15 pm

1 stop7h 30m

Manchester

Fri 8/7

5:40 am-5:10 pm

2 stops11h 30m

$383

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Manchester, New Hampshire?

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of June, then book flights to Manchester, New Hampshire from Knoxville during February instead. Flights to Manchester, New Hampshire in February, while not as cheap as those in June, still average around $329.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Knoxville to Manchester, New Hampshire takes 3h 55m
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

Frequently asked questions about flying from Knoxville to Manchester, New Hampshire

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 3h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,705 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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