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Cheap flights from Knoxville to Boston from $157

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Boston departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Boston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
8:20 am - 12:00 pmTYS  Knoxville McGhee Tyson-MHT Manchester
3h 40m1 stop Baltimore/Washington
Southwest Logo
6:20 am - 1:10 pmMHT  Manchester-TYS Knoxville McGhee Tyson
6h 50m1 stop Orlando
$333Southwest
Fri, Oct 23 - Fri, Oct 30
American Airlines Logo
6:32 pm - 11:36 pmTYS  Knoxville McGhee Tyson-MHT Manchester
5h 04m1 stop Philadelphia
American Airlines Logo
6:00 am - 10:45 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 45m1 stop Washington, D.C. Reagan-National
$339American Airlines
Thu, Sep 3 - Tue, Sep 8
American Airlines Logo
3:41 pm - 10:52 pmTYS  Knoxville McGhee Tyson-MHT Manchester
7h 11m1 stop Charlotte Douglas
American Airlines Logo
11:14 am - 3:22 pmMHT  Manchester-TYS Knoxville McGhee Tyson
4h 08m1 stop Charlotte Douglas
$345American Airlines
Sat, Sep 5 - Sat, Sep 12
United Airlines Logo
7:00 am - 7:00 pmTYS  Knoxville McGhee Tyson-MHT Manchester
12h 00m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
9:25 am - 2:37 pmMHT  Manchester-TYS Knoxville McGhee Tyson
5h 12m1 stop Washington, D.C. Dulles Intl
$350United Airlines
Sat, Sep 5 - Sat, Sep 12
United Airlines Logo
7:00 am - 7:00 pmTYS  Knoxville McGhee Tyson-MHT Manchester
12h 00m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
9:25 am - 10:49 pmMHT  Manchester-TYS Knoxville McGhee Tyson
13h 24m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl
$355United Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:32 pm - 11:36 pmTYS  Knoxville McGhee Tyson-MHT Manchester
5h 04m1 stop Philadelphia
American Airlines Logo
6:00 am - 10:45 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 45m1 stop Washington, D.C. Reagan-National
$363American Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
4:52 pm - 10:56 pmTYS  Knoxville McGhee Tyson-MHT Manchester
6h 04m1 stop Charlotte Douglas
American Airlines Logo
11:10 am - 3:27 pmMHT  Manchester-TYS Knoxville McGhee Tyson
4h 17m1 stop Philadelphia
$363American Airlines
Thu, Oct 29 - Sun, Nov 1
American Airlines Logo
7:31 pm - 11:52 pmTYS  Knoxville McGhee Tyson-MHT Manchester
4h 21m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:00 am - 10:45 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 45m1 stop Washington, D.C. Reagan-National
$363American Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
12:42 pm - 6:14 pmTYS  Knoxville McGhee Tyson-MHT Manchester
5h 32m1 stop Philadelphia
American Airlines Logo
7:12 pm - 11:58 pmMHT  Manchester-TYS Knoxville McGhee Tyson
4h 46m1 stop Charlotte Douglas
$363American Airlines
Sat, Nov 14 - Sun, Nov 15
American Airlines Logo
4:46 pm - 11:31 pmTYS  Knoxville McGhee Tyson-MHT Manchester
6h 45m1 stop Philadelphia
American Airlines Logo
6:00 am - 10:33 amMHT  Manchester-TYS Knoxville McGhee Tyson
4h 33m1 stop Philadelphia
$387American Airlines
Wed, Sep 30 - Wed, Oct 7

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Southwest flights from Knoxville to Manchester, New Hampshire

Our best Southwest deals on Knoxville to Manchester, New Hampshire flight tickets
Southwest
Oct 23
TYS8:20 amKnoxville McGhee Tyson
3h 40m
1 stop
MHT12:00 pmManchester
Oct 30
MHT6:20 amManchester
6h 50m
1 stop
TYS1:10 pmKnoxville McGhee Tyson
$333
Southwest
Oct 23
TYS1:50 pmKnoxville McGhee Tyson
10h 05m
2 stops
MHT11:55 pmManchester
Oct 30
MHT6:20 amManchester
6h 50m
1 stop
TYS1:10 pmKnoxville McGhee Tyson
$400
Southwest
Nov 14
TYS8:15 amKnoxville McGhee Tyson
4h 05m
1 stop
MHT12:20 pmManchester
Nov 15
MHT5:30 amManchester
11h 20m
2 stops
TYS4:50 pmKnoxville McGhee Tyson
$404

American Airlines flights from Knoxville to Manchester, New Hampshire

Our best American Airlines deals on Knoxville to Manchester, New Hampshire flight tickets
American Airlines
Sep 3
TYS6:32 pmKnoxville McGhee Tyson
5h 04m
1 stop
MHT11:36 pmManchester
Sep 8
MHT6:00 amManchester
4h 45m
1 stop
TYS10:45 amKnoxville McGhee Tyson
$339
American Airlines
Sep 5
TYS3:41 pmKnoxville McGhee Tyson
7h 11m
1 stop
MHT10:52 pmManchester
Sep 12
MHT11:14 amManchester
4h 08m
1 stop
TYS3:22 pmKnoxville McGhee Tyson
$345
American Airlines
Sep 4
TYS6:32 pmKnoxville McGhee Tyson
5h 04m
1 stop
MHT11:36 pmManchester
Sep 7
MHT6:00 amManchester
4h 45m
1 stop
TYS10:45 amKnoxville McGhee Tyson
$363

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Manchester, New Hampshire that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 9, 2026.
Use the filters below to find and compare flights from Knoxville to Manchester, New Hampshire that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Fri 10/23

8:20 am-12:00 pm

1 stop3h 40m

Manchester

Fri 10/30

6:20 am-1:10 pm

1 stop6h 50m

$333

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Thu 9/3

6:32 pm-11:36 pm

1 stop5h 04m

Manchester

Tue 9/8

6:00 am-10:45 am

1 stop4h 45m

$339

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Sat 9/5

3:41 pm-10:52 pm

1 stop7h 11m

Manchester

Sat 9/12

11:14 am-3:22 pm

1 stop4h 08m

$345

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Sat 9/5

7:00 am-7:00 pm

2 stops12h 00m

Manchester

Sat 9/12

9:25 am-2:37 pm

1 stop5h 12m

$350

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Sat 9/5

7:00 am-7:00 pm

2 stops12h 00m

Manchester

Sat 9/12

9:25 am-10:49 pm

2 stops13h 24m

$355

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Fri 9/4

6:32 pm-11:36 pm

1 stop5h 04m

Manchester

Mon 9/7

6:00 am-10:45 am

1 stop4h 45m

$363

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Thu 10/29

4:52 pm-10:56 pm

1 stop6h 04m

Manchester

Sun 11/1

11:10 am-3:27 pm

1 stop4h 17m

$363
Quickest round-trip

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Fri 9/4

7:31 pm-11:52 pm

1 stop4h 21m

Manchester

Mon 9/7

6:00 am-10:45 am

1 stop4h 45m

$363

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Sat 11/14

12:42 pm-6:14 pm

1 stop5h 32m

Manchester

Sun 11/15

7:12 pm-11:58 pm

1 stop4h 46m

$363

KnoxvilleManchester

TYS Knoxville McGhee Tyson - MHT Manchester

TYSMHT

Knoxville McGhee Tyson

Wed 9/30

4:46 pm-11:31 pm

1 stop6h 45m

Manchester

Wed 10/7

6:00 am-10:33 am

1 stop4h 33m

$387

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Manchester, New Hampshire

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Manchester, New Hampshire?

Prices are currently typical for flights on this route.

Typical prices usually range from $323 to $586.
The lowest price recently found on this route was $333.

What is the cheapest month to fly to Manchester, New Hampshire?

If you aren’t able to travel during the month of February, then book flights to Manchester, New Hampshire from Knoxville during June instead. Flights to Manchester, New Hampshire in June, while not as cheap as those in February, still average around $343.

When to book flights from Knoxville to Manchester, New Hampshire

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Manchester, New Hampshire according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Manchester, New Hampshire (TYS to MHT) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Manchester, New Hampshire

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Knoxville to Manchester, New Hampshire takes 4h 05m
There are no direct flights from Knoxville to Manchester, New Hampshire. There are no popular flight routes from Knoxville to Manchester, New Hampshire.
Search flight deals

Frequently asked questions about flying from Knoxville to Manchester, New Hampshire

  • How far is Knoxville McGhee Tyson to Manchester by plane?

    Knoxville McGhee Tyson and Manchester are 821.5 mi apart from one another. By plane, this route typically takes 4h 05m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Manchester Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Manchester Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Manchester Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Manchester Airport.

  • What documentation or ID do you need to fly to Manchester Airport?

    The required travel and health documents for your Manchester Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Manchester Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Manchester, New Hampshire?

Best airlines flying from Knoxville to Manchester, New Hampshire

Compare and see reviews for airlines that fly from Knoxville to Manchester, New Hampshire with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,893 reviews
Search American Airlines flights

Traveling to a place near Boston?

Book flights to Boston if you plan to visit one of these locations
Keene

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Manchester?

Finding the right flight to Manchester from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Manchester quick and easy, saving you time and money.

Can I find flights from Knoxville to Manchester with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Manchester from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Manchester?

momondo helps you find the best flight between Knoxville and Manchester by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Manchester right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Knoxville to Manchester flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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