How many flights depart from Knoxville to Chicago on average per day?

As of May 2026, 11 flights take off from Knoxville and land in Chicago each day. The most common flight departure time for this route is 7:00AM, with 54% of daily flights taking off at noon.

What airlines fly to Chicago?

United Airlines, American Airlines and Delta are the top three most popular airlines that fly to Chicago from Knoxville according to our data. United Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 4 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

How many flights depart from Knoxville to Chicago on average per week?

As of May 2026, 78 flights take off from Knoxville and land in Chicago each week. The most common flight departure day for this route is Wed, with 42% of weekly flights taking off on this day.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Chicago?

Southwest, United Airlines, and Delta are the most popular carriers operating from Knoxville McGhee Tyson to Chicago

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago?

Prices for flights from Knoxville McGhee Tyson Airport to Chicago are updated daily.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago?

As of May 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Chicago.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago.

What documentation or ID do you need to fly to Chicago?

The travel and health documents you'll need for your trip to Chicago may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$48 Cheap Flights from Knoxville to Chicago in 2026

Q: What is the typical price of a round-trip flight between Knoxville and Chicago?

Prices are currently low for flights on this route. Typical prices usually range from $324 to $164. The lowest price recently found on this route was $171.

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1:22 pm - 1:56 pm

TYS

MDW

1h 34mnonstop

2:46 pm - 5:14 pm

MDW

TYS

1h 28mnonstop

$171Allegiant Air

Thu, Jun 11 - Sun, Jun 14

1:22 pm - 1:58 pm

TYS

MDW

1h 36mnonstop

2:48 pm - 5:18 pm

MDW

TYS

1h 30mnonstop

$172Allegiant Air

Thu, Jul 23 - Sun, Jul 26

1:22 pm - 1:56 pm

TYS

MDW

1h 34mnonstop

2:46 pm - 5:14 pm

MDW

TYS

1h 28mnonstop

$174Allegiant Air

Thu, Jun 11 - Sun, Jun 14

1:22 pm - 1:57 pm

TYS

MDW

1h 35mnonstop

9:23 pm - 9:38 pm

MDW

TYS

23h 15m

1 stop

$180Allegiant Air

Thu, May 28 - Fri, Jun 5

8:00 am - 10:08 pm

TYS

MDW

15h 08m

2 stops

2:49 pm - 5:19 pm

MDW

TYS

1h 30mnonstop

$193Multiple Airlines

Wed, Jul 29 - Thu, Aug 6

1:22 pm - 1:56 pm

TYS

MDW

1h 34mnonstop

6:00 am - 9:50 pm

MDW

TYS

14h 50m

2 stops

$201Multiple Airlines

Thu, Jun 25 - Mon, Jun 29

6:32 pm - 7:50 pm

TYS

ORD

2h 18mnonstop

7:09 pm - 9:58 pm

ORD

TYS

1h 49mnonstop

$246American Airlines

Thu, Jul 2 - Thu, Jul 9

6:00 am - 6:59 am

TYS

ORD

1h 59mnonstop

6:07 pm - 8:56 pm

ORD

TYS

1h 49mnonstop

$249United Airlines

Fri, Jun 12 - Sat, Jun 13

7:46 am - 8:54 am

TYS

ORD

2h 08mnonstop

8:05 am - 10:58 am

ORD

TYS

1h 53mnonstop

$250American Airlines

Sat, Jun 20 - Tue, Jun 23

6:00 am - 6:59 am

TYS

ORD

1h 59mnonstop

7:45 pm - 10:34 pm

ORD

TYS

1h 49mnonstop

$260United Airlines

Sun, Jun 7 - Thu, Jun 25

American Airlines flights from Knoxville to Chicago

Our best American Airlines deals on Knoxville to Chicago flight tickets

American Airlines

Jul 2

TYS6:32 pmKnoxville McGhee Tyson

2h 18m

ORD7:50 pmChicago O'Hare Intl

Jul 9

ORD7:09 pmChicago O'Hare Intl

1h 49m

TYS9:58 pmKnoxville McGhee Tyson

$246

American Airlines

Jun 20

TYS7:46 amKnoxville McGhee Tyson

2h 08m

ORD8:54 amChicago O'Hare Intl

Jun 23

ORD8:05 amChicago O'Hare Intl

1h 53m

TYS10:58 amKnoxville McGhee Tyson

$250

American Airlines

Jul 2

TYS8:05 pmKnoxville McGhee Tyson

4h 56m

1 stop

ORD12:01 amChicago O'Hare Intl

Jul 9

ORD7:09 pmChicago O'Hare Intl

1h 49m

TYS9:58 pmKnoxville McGhee Tyson

$255

United Airlines flights from Knoxville to Chicago

Our best United Airlines deals on Knoxville to Chicago flight tickets

United Airlines

Jun 12

TYS6:00 amKnoxville McGhee Tyson

1h 59m

ORD6:59 amChicago O'Hare Intl

Jun 13

ORD6:07 pmChicago O'Hare Intl

1h 49m

TYS8:56 pmKnoxville McGhee Tyson

$249

United Airlines

Jun 7

TYS6:00 amKnoxville McGhee Tyson

1h 59m

ORD6:59 amChicago O'Hare Intl

Jun 25

ORD7:45 pmChicago O'Hare Intl

1h 49m

TYS10:34 pmKnoxville McGhee Tyson

$260

United Airlines

Jun 25

TYS6:00 amKnoxville McGhee Tyson

1h 59m

ORD6:59 amChicago O'Hare Intl

Jun 28

ORD7:45 pmChicago O'Hare Intl

1h 49m

TYS10:34 pmKnoxville McGhee Tyson

$262

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/11

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Sun 6/14

2:46 pm-5:14 pm

Nonstop1h 28m

$171

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 7/23

1:22 pm-1:58 pm

Nonstop1h 36m

Chicago Midway

Sun 7/26

2:48 pm-5:18 pm

Nonstop1h 30m

$172

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/11

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Sun 6/14

2:46 pm-5:14 pm

Nonstop1h 28m

$174

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 5/28

1:22 pm-1:57 pm

Nonstop1h 35m

Chicago Midway

Fri 6/5

9:23 pm-9:38 pm

1 stop23h 15m

$180

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Wed 7/29

8:00 am-10:08 pm

2 stops15h 08m

Chicago Midway

Thu 8/6

2:49 pm-5:19 pm

Nonstop1h 30m

$193

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 6/25

1:22 pm-1:56 pm

Nonstop1h 34m

Chicago Midway

Mon 6/29

6:00 am-9:50 pm

2 stops14h 50m

$201

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Thu 7/2

6:32 pm-7:50 pm

Nonstop2h 18m

Chicago O'Hare Intl

Thu 7/9

7:09 pm-9:58 pm

Nonstop1h 49m

$246

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 6/12

6:00 am-6:59 am

Nonstop1h 59m

Chicago O'Hare Intl

Sat 6/13

6:07 pm-8:56 pm

Nonstop1h 49m

$249

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sat 6/20

7:46 am-8:54 am

Nonstop2h 08m

Chicago O'Hare Intl

Tue 6/23

8:05 am-10:58 am

Nonstop1h 53m

$250

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sun 6/7

6:00 am-6:59 am

Nonstop1h 59m

Chicago O'Hare Intl

Thu 6/25

7:45 pm-10:34 pm

Nonstop1h 49m

$260

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Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Chicago

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the typical price of a round-trip flight between Knoxville and Chicago?

What is the cheapest month to fly to Chicago?

The month of November is, on average, the cheapest month to fly to Chicago from Knoxville, with most prices found around $48. If you’re not able to fly to Chicago in November, then September is your next best option. Flight prices from Knoxville to Chicago during September average around $49.

What is the cheapest day to depart on your flight to Chicago?

The cheapest day to depart on your flight to Chicago is on a Friday when prices can be found for as low as $371. This is often the case because there is less demand to fly during this day of the week. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Chicago for around $708.

What is the cheapest time of day to depart on your flight to Chicago?

Our most recent data shows that the best time of day to fly to Chicago is in the morning. Flights from Knoxville to Chicago during this time can be as low as $487. In contrast, the most expensive time of day to depart to Chicago is at noon when prices are around $578.

What is the cheapest Knoxville McGhee Tyson to Chicago flight route?

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago flight prices

How far in advance should I book a flight from Knoxville to Chicago?

You are more likely to see cheaper flights to Chicago from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $293 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Knoxville for as low as $193 on momondo.

What cabin class options are available on Knoxville to Chicago flights?

There are 4 cabin classes available to choose from on Knoxville to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Chicago flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Chicago.

How have Knoxville to Chicago flight prices changed over time?

As of May 2026, prices for Knoxville to Chicago flights are approximately 42% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Chicago

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Chicago according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Chicago (TYS to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago

Best Price Found	$80
Fastest flight time	1h 34m
Direct flights	Mon, Tue, Wed, Fri, Sat and Sun
Airports in Chicago	3 airports

The best one-way flight to Chicago from Knoxville in the past 72 hours is $80. The best round-trip flight deal from Knoxville to Chicago found on momondo in the last 72 hours is $109.

The fastest flight from Knoxville to Chicago takes 1h 34m

Direct flights go from Knoxville to Chicago on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. Airlines offering direct flights are: United Airlines and Allegiant Air.

There are 3 airports in Chicago. From Knoxville there are direct flights to Chicago O'Hare Intl (ORD), Chicago Midway (MDW).

Search flight deals

Frequently asked questions about flying from Knoxville to Chicago

How far is Knoxville McGhee Tyson to Chicago by plane?
Chicago is 454.2 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 1h 34m.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Chicago?
Prices for flights from Knoxville McGhee Tyson Airport to Chicago are updated daily.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Chicago?
As of May 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Chicago.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Chicago?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Chicago.
What documentation or ID do you need to fly to Chicago?
The travel and health documents you'll need for your trip to Chicago may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Chicago. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Knoxville to Chicago?
Based on momondo bookings for flights between Knoxville and Chicago, the leading plane model is Canadair (Bombardier) Regional Jet 700, making up 21.59% of the total bookings. Other popular models include Canadair (Bombardier) Regional Jet CRJ-550 with 21.08%, Airbus A319 with 12.95%, and Embraer 175 (Enhanced Winglets) with 11.24%.
What is the most popular airline from Knoxville to Chicago?
Based on momondo bookings for flights between Knoxville and Chicago, the leading airline is American Airlines, making up 41% of the total bookings. Other popular airlines include United Airlines with 40% and Allegiant Air with 19%.

Best airlines flying from Knoxville to Chicago

Compare and see reviews for airlines that fly from Knoxville to Chicago with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $60	Free Cancellation	Rating 7.3 709 reviews	Search Allegiant Air flights
United Airlines	PriceFrom $189	Free Cancellation	Rating 7.4 9,739 reviews	Search United Airlines flights
American Airlines	PriceFrom $189	Free Cancellation	Rating 7.1 11,644 reviews	Search American Airlines flights

United Airlines Flights From Knoxville to Chicago
United Airlines operates around 5 flights from Knoxville to Chicago every week. The average price of these flights found in the last 72 hours has been $316, but momondo users have found United Airlines deals from Knoxville to Chicago from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 9,739 reviews.
American Airlines Flights From Knoxville to Chicago
American Airlines (7.1/10 from 11,644 reviews) operates around 12 flights from Knoxville to Chicago in any given week. The average American Airlines airfare for this route is around $290, with deals from around $189 rare but found on momondo. Referenced prices are for round-trip Knoxville to Chicago flight searches in the last 72 hours.

Merrillville

New Buffalo

Hammond

Saint Joseph

Benton Harbor

Portage

Lansing

Valparaiso

Munster

Schererville

Crown Point

Chesterton

Monticello

Porter

Griffith

Saint John

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Chicago?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to Chicago. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to Chicago with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Chicago flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Chicago?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Chicago.

I’m not ready to book a flight from Knoxville to Chicago right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Chicago flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Cheap flights from Knoxville to Chicago from $48

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Chicago departing on 6/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Knoxville to Chicago

What is the typical price of a round-trip flight between Knoxville and Chicago?

What is the cheapest month to fly to Chicago?

What is the cheapest day to depart on your flight to Chicago?

What is the cheapest time of day to depart on your flight to Chicago?

What is the cheapest Knoxville McGhee Tyson to Chicago flight route?

How far in advance should I book a flight from Knoxville to Chicago?

What cabin class options are available on Knoxville to Chicago flights?

Can stopping save me money on Knoxville to Chicago flights?

How have Knoxville to Chicago flight prices changed over time?

What is the cheapest airline that flies from Knoxville McGhee Tyson to Chicago?

What airlines fly to Chicago?

How many flights depart from Knoxville to Chicago on average per day?

How many flights depart from Knoxville to Chicago on average per week?

When to book flights from Knoxville to Chicago

Cheap Knoxville to Chicago (TYS to CHI) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Chicago

Best Price Found

Fastest flight time

Direct flights

Airports in Chicago

Frequently asked questions about flying from Knoxville to Chicago

Best airlines flying from Knoxville to Chicago

Compare and see reviews for airlines that fly from Knoxville to Chicago with momondo

United Airlines Flights From Knoxville to Chicago

American Airlines Flights From Knoxville to Chicago

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Why use momondo?

An easier way to manage your Chicago trip

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Airports listed have a maximum distance of 78.5 mi from Chicago

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