Cheap flights from Knoxville to Chicago from $45

The month of January is, on average, the cheapest month to fly to Chicago from Knoxville, with most prices found around $245. If you’re not able to fly to Chicago in January, then April is your next best option. Flight prices from Knoxville to Chicago during April average around $263.

The cheapest day to depart on your flight to Chicago is on a Friday when prices can be found for as low as $416. This is often the case because there is less demand to fly during this day of the week. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Knoxville to Chicago for around $789.

Our most recent data shows that the best time of day to fly to Chicago is in the evening. Flights from Knoxville to Chicago during this time can be as low as $397. In contrast, the most expensive time of day to depart to Chicago is at noon when prices are around $717.

Fly from Knoxville McGhee Tyson to Chicago Midway for the best Knoxville McGhee Tyson - Chicago flight prices

You are more likely to see cheaper flights to Chicago from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Chicago for around $328 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Chicago from Knoxville for as low as $236 on momondo.

There are 4 cabin classes available to choose from on Knoxville to Chicago flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Knoxville to Chicago.

As of October 2026, prices for Knoxville to Chicago flights are approximately 64% more expensive when compared to flights at the same time last year.

Allegiant Air, Southwest, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Chicago

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Chicago from Knoxville according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Chicago. Keep in mind that there are 4 different airlines that fly to Chicago on a routine basis, so you have a few additional options to choose from.

As of October 2026, 31 flights take off from Knoxville and land in Chicago each day. The most common flight departure time for this route is 6:00PM, with 50% of daily flights taking off at noon.

As of October 2026, 217 flights take off from Knoxville and land in Chicago each week. The most common flight departure day for this route is Fri, with 17% of weekly flights taking off on this day.