What is the cheapest airline that flies from Knoxville McGhee Tyson to Buffalo?

Frontier, American Airlines, and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Buffalo

What airlines fly to Buffalo?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Buffalo from Knoxville according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 3 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

As of August 2025, there are 2 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$117 Cheap Flights from Knoxville to Buffalo in 2025

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Find the cheapest flights from Knoxville to Buffalo

Round-trip

One-way

Last minute

Cheap round-trip flights

8:40 pm - 4:02 pmTYS-BUF

19h 22m1 stop

4:57 pm - 7:45 pmBUF-TYS

26h 48m1 stop

$225Frontier

Find Deal

Thu, Sep 18 - Sun, Sep 21

5:20 pm - 11:55 pmTYS-BUF

6h 35m1 stop

7:29 pm - 12:07 amBUF-TYS

4h 38m1 stop

$249American Airlines

Find Deal

Fri, Sep 12 - Sun, Sep 14

3:04 pm - 9:52 pmTYS-BUF

6h 48m1 stop

6:29 am - 12:26 pmBUF-TYS

5h 57m1 stop

$254American Airlines

Find Deal

Fri, Aug 22 - Sun, Aug 24

2:52 pm - 6:48 pmTYS-BUF

3h 56m1 stop

6:24 am - 12:43 pmBUF-TYS

6h 19m1 stop

$279American Airlines

Find Deal

Sat, Nov 1 - Mon, Nov 3

10:36 am - 5:21 pmTYS-BUF

6h 45m1 stop

11:56 am - 4:57 pmBUF-TYS

5h 01m1 stop

$284American Airlines

Find Deal

Thu, Aug 14 - Mon, Aug 18

8:31 pm - 12:12 amTYS-BUF

3h 41m1 stop

7:40 am - 11:50 amBUF-TYS

4h 10m1 stop

$304American Airlines

Find Deal

Sun, Sep 21 - Sat, Sep 27

5:45 am - 3:25 pmTYS-BUF

9h 40m2 stops

5:55 pm - 10:50 pmBUF-TYS

4h 55m1 stop

$336United Airlines

Find Deal

Tue, Sep 23 - Thu, Oct 2

7:00 am - 11:59 pmTYS-BUF

16h 59m2 stops

6:00 am - 10:28 amBUF-TYS

4h 28m1 stop

$402United Airlines

Find Deal

Thu, Sep 18 - Sun, Sep 21

7:00 am - 11:59 pmTYS-BUF

16h 59m2 stops

8:00 pm - 11:57 pmBUF-TYS

3h 57m1 stop

$403United Airlines

Find Deal

Fri, Sep 12 - Mon, Sep 15

2:41 pm - 10:52 pmTYS-BUF

8h 11m2 stops

6:20 am - 2:51 pmBUF-TYS

8h 31m2 stops

$1,746Delta

Find Deal

Sat, Nov 1 - Mon, Nov 3

American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets

American Airlines

Sep 12

TYS5:20 pmKnoxville McGhee Tyson

6h 35m

1 stop

BUF11:55 pmBuffalo

Sep 14

BUF7:29 pmBuffalo

4h 38m

1 stop

TYS12:07 amKnoxville McGhee Tyson

$249

Find similar

American Airlines

Aug 22

TYS3:04 pmKnoxville McGhee Tyson

6h 48m

1 stop

BUF9:52 pmBuffalo

Aug 24

BUF6:29 amBuffalo

5h 57m

1 stop

TYS12:26 pmKnoxville McGhee Tyson

$254

Find similar

American Airlines

Nov 1

TYS2:52 pmKnoxville McGhee Tyson

3h 56m

1 stop

BUF6:48 pmBuffalo

Nov 3

BUF6:24 amBuffalo

6h 19m

1 stop

TYS12:43 pmKnoxville McGhee Tyson

$279

Find similar

United Airlines flights from Knoxville to Buffalo

Our best United Airlines deals on Knoxville to Buffalo flight tickets

United Airlines

Sep 23

TYS5:45 amKnoxville McGhee Tyson

9h 40m

2 stops

BUF3:25 pmBuffalo

Oct 2

BUF5:55 pmBuffalo

4h 55m

1 stop

TYS10:50 pmKnoxville McGhee Tyson

$336

Find similar

United Airlines

Sep 18

TYS7:00 amKnoxville McGhee Tyson

16h 59m

2 stops

BUF11:59 pmBuffalo

Sep 21

BUF6:00 amBuffalo

4h 28m

1 stop

TYS10:28 amKnoxville McGhee Tyson

$402

Find similar

United Airlines

Sep 12

TYS7:00 amKnoxville McGhee Tyson

16h 59m

2 stops

BUF11:59 pmBuffalo

Sep 15

BUF8:00 pmBuffalo

3h 57m

1 stop

TYS11:57 pmKnoxville McGhee Tyson

$403

Find similar

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 9/18

8:40 pm-4:02 pm

1 stop19h 22m

Buffalo

Sun 9/21

4:57 pm-7:45 pm

1 stop26h 48m

$225

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 9/12

5:20 pm-11:55 pm

1 stop6h 35m

Buffalo

Sun 9/14

7:29 pm-12:07 am

1 stop4h 38m

$249

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 8/22

3:04 pm-9:52 pm

1 stop6h 48m

Buffalo

Sun 8/24

6:29 am-12:26 pm

1 stop5h 57m

$254

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 11/1

2:52 pm-6:48 pm

1 stop3h 56m

Buffalo

Mon 11/3

6:24 am-12:43 pm

1 stop6h 19m

$279

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 8/14

10:36 am-5:21 pm

1 stop6h 45m

Buffalo

Mon 8/18

11:56 am-4:57 pm

1 stop5h 01m

$284

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sun 9/21

8:31 pm-12:12 am

1 stop3h 41m

Buffalo

Sat 9/27

7:40 am-11:50 am

1 stop4h 10m

$304

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 9/23

5:45 am-3:25 pm

2 stops9h 40m

Buffalo

Thu 10/2

5:55 pm-10:50 pm

1 stop4h 55m

$336

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 9/18

7:00 am-11:59 pm

2 stops16h 59m

Buffalo

Sun 9/21

6:00 am-10:28 am

1 stop4h 28m

$402

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 9/12

7:00 am-11:59 pm

2 stops16h 59m

Buffalo

Mon 9/15

8:00 pm-11:57 pm

1 stop3h 57m

$403

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 11/1

2:41 pm-10:52 pm

2 stops8h 11m

Buffalo

Mon 11/3

6:20 am-2:51 pm

2 stops8h 31m

$1,746

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of October, then book flights to Buffalo from Knoxville during March instead. Flights to Buffalo in March, while not as cheap as those in October, still average around $237.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Wednesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $248. Flights from Knoxville to Buffalo on a Monday will generally be more expensive and average around $513. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from Knoxville to Buffalo when you can find flight prices for as low as $283. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $407 per ticket.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Best Price Found	$117
Fastest flight time	3h 41m
Direct flights	None
Airports in Buffalo	1 airport

The best one-way flight to Buffalo from Knoxville in the past 72 hours is $117. The best round-trip flight deal from Knoxville to Buffalo found on momondo in the last 72 hours is $225.

The fastest flight from Knoxville to Buffalo takes 3h 41m

There are no direct flights from Knoxville to Buffalo. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - Buffalo Airport.

There is 1 airport near Buffalo: Buffalo (BUF)

Search flight deals

How far is Knoxville McGhee Tyson to Buffalo by plane?
There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 3h 41m is a normal flight duration for this route.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
As of August 2025, there are 2 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Knoxville to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Knoxville to Buffalo is American Airlines, representing 79% of all bookings. The subsequent popular airline is Delta at 21%.

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights
Delta	PriceFrom $198	Free Cancellation	Rating 8.0 7,987 reviews		Search Delta flights

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Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.