What is the cheapest airline that flies from Knoxville McGhee Tyson to Buffalo?

Delta and United Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Buffalo

What airlines fly to Buffalo?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Buffalo from Knoxville according to our data. American Airlines is the first choice among our users, with 67% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 4 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

As of November 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$155 Cheap Flights from Knoxville to Buffalo in 2026/27

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5:40 am - 11:05 amTYS Knoxville McGhee Tyson-BUF Buffalo

5h 25m1 stop Atlanta Hartsfield-Jackson

12:06 pm - 6:22 pmBUF Buffalo-TYS Knoxville McGhee Tyson

6h 16m1 stop Detroit Metropolitan Wayne County

$287Delta

Sat, Dec 12 - Tue, Dec 15

10:41 am - 5:36 pmTYS Knoxville McGhee Tyson-BUF Buffalo

6h 55m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:27 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 27m1 stop Atlanta Hartsfield-Jackson

$319Delta

Thu, Dec 3 - Sun, Dec 13

7:18 am - 11:54 amTYS Knoxville McGhee Tyson-BUF Buffalo

4h 36m1 stop Detroit Metropolitan Wayne County

6:59 pm - 11:58 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 59m1 stop Atlanta Hartsfield-Jackson

$324Delta

Sat, Jan 9 - Mon, Jan 11

7:45 am - 12:15 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 30m1 stop Baltimore/Washington

3:45 pm - 7:45 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 00m1 stop Baltimore/Washington

$334Southwest

Wed, Jan 6 - Wed, Jan 6

9:45 am - 2:20 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 35m1 stop Washington, D.C. Dulles Intl

11:23 am - 7:47 pmBUF Buffalo-TYS Knoxville McGhee Tyson

8h 24m2 stops Newark Washington, D.C. Dulles Intl

$338United Airlines

Sat, Dec 12 - Tue, Dec 15

7:45 am - 12:00 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 15m1 stop Baltimore/Washington

5:45 am - 12:15 pmBUF Buffalo-TYS Knoxville McGhee Tyson

6h 30m2 stops Baltimore/Washington Nashville Intl

$344Southwest

Sat, Jan 9 - Mon, Jan 11

6:00 am - 2:20 pmTYS Knoxville McGhee Tyson-BUF Buffalo

8h 20m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:00 am - 11:39 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 39m1 stop Newark

$345United Airlines

Thu, Dec 3 - Sun, Dec 13

2:25 pm - 10:45 pmTYS Knoxville McGhee Tyson-BUF Buffalo

8h 20m2 stops Nashville Intl Baltimore/Washington

5:45 am - 12:15 pmBUF Buffalo-TYS Knoxville McGhee Tyson

6h 30m2 stops Baltimore/Washington Nashville Intl

$359Southwest

Sat, Jan 9 - Mon, Jan 11

6:13 pm - 12:05 amTYS Knoxville McGhee Tyson-BUF Buffalo

5h 52m1 stop Washington, D.C. Reagan-National

5:28 am - 11:04 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 36m1 stop Washington, D.C. Reagan-National

$621American Airlines

Sun, Nov 22 - Wed, Nov 25

8:14 am - 3:43 pmTYS Knoxville McGhee Tyson-BUF Buffalo

7h 29m2 stops Charlotte Douglas Boston Logan Intl

6:30 pm - 12:28 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 58m1 stop Chicago O'Hare Intl

$685American Airlines

Fri, Jan 8 - Fri, Jan 8

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United Airlines flights from Knoxville to Buffalo

Our best United Airlines deals on Knoxville to Buffalo flight tickets

United Airlines

Dec 12

TYS9:45 amKnoxville McGhee Tyson

4h 35m

1 stop

BUF2:20 pmBuffalo

Dec 15

BUF11:23 amBuffalo

8h 24m

2 stops

TYS7:47 pmKnoxville McGhee Tyson

$338

United Airlines

Dec 3

TYS6:00 amKnoxville McGhee Tyson

8h 20m

2 stops

BUF2:20 pmBuffalo

Dec 13

BUF6:00 amBuffalo

5h 39m

1 stop

TYS11:39 amKnoxville McGhee Tyson

$345

United Airlines

Dec 3

TYS6:20 amKnoxville McGhee Tyson

4h 29m

1 stop

BUF10:49 amBuffalo

Dec 7

BUF6:00 amBuffalo

5h 39m

1 stop

TYS11:39 amKnoxville McGhee Tyson

$387

Delta flights from Knoxville to Buffalo

Our best Delta deals on Knoxville to Buffalo flight tickets

Delta

Dec 12

TYS5:40 amKnoxville McGhee Tyson

5h 25m

1 stop

BUF11:05 amBuffalo

Dec 15

BUF12:06 pmBuffalo

6h 16m

1 stop

TYS6:22 pmKnoxville McGhee Tyson

$287

Delta

Dec 3

TYS10:41 amKnoxville McGhee Tyson

6h 55m

1 stop

BUF5:36 pmBuffalo

Dec 13

BUF6:00 amBuffalo

5h 27m

1 stop

TYS11:27 amKnoxville McGhee Tyson

$319

Delta

Jan 9

TYS7:18 amKnoxville McGhee Tyson

4h 36m

1 stop

BUF11:54 amBuffalo

Jan 11

BUF6:59 pmBuffalo

4h 59m

1 stop

TYS11:58 pmKnoxville McGhee Tyson

$324

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 12/12

5:40 am-11:05 am

1 stop5h 25m

Buffalo

Tue 12/15

12:06 pm-6:22 pm

1 stop6h 16m

$287

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Thu 12/3

10:41 am-5:36 pm

1 stop6h 55m

Buffalo

Sun 12/13

6:00 am-11:27 am

1 stop5h 27m

$319

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 1/9

7:18 am-11:54 am

1 stop4h 36m

Buffalo

Mon 1/11

6:59 pm-11:58 pm

1 stop4h 59m

$324

Quickest round-trip

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Wed 1/6

7:45 am-12:15 pm

1 stop4h 30m

Buffalo

Wed 1/6

3:45 pm-7:45 pm

1 stop4h 00m

$334

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 12/12

9:45 am-2:20 pm

1 stop4h 35m

Buffalo

Tue 12/15

11:23 am-7:47 pm

2 stops8h 24m

$338

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 1/9

7:45 am-12:00 pm

1 stop4h 15m

Buffalo

Mon 1/11

5:45 am-12:15 pm

2 stops6h 30m

$344

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Thu 12/3

6:00 am-2:20 pm

2 stops8h 20m

Buffalo

Sun 12/13

6:00 am-11:39 am

1 stop5h 39m

$345

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 1/9

2:25 pm-10:45 pm

2 stops8h 20m

Buffalo

Mon 1/11

5:45 am-12:15 pm

2 stops6h 30m

$359

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sun 11/22

6:13 pm-12:05 am

1 stop5h 52m

Buffalo

Wed 11/25

5:28 am-11:04 am

1 stop5h 36m

$621

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 1/8

8:14 am-3:43 pm

2 stops7h 29m

Buffalo

Fri 1/8

6:30 pm-12:28 am

1 stop5h 58m

$685

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of October, then book flights to Buffalo from Knoxville during May instead. Flights to Buffalo in May, while not as cheap as those in October, still average around $318.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Best Price Found	$155
Fastest flight time	4h 12m
Direct flights	None

The best one-way flight to Buffalo from Knoxville in the past 72 hours is $155. The best round-trip flight deal from Knoxville to Buffalo found on momondo in the last 72 hours is $287.

The fastest flight from Knoxville to Buffalo takes 4h 12m

There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.

Search flight deals

Frequently asked questions about flying from Knoxville to Buffalo

How far is Knoxville McGhee Tyson to Buffalo by plane?
There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 4h 12m is a normal flight duration for this route.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
As of November 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Knoxville to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Knoxville to Buffalo is American Airlines, representing 58% of all bookings. The subsequent popular airlines are Southwest at 24% and Delta at 18%.

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $232	Free Cancellation	Rating 7.8 8,700 reviews	Search Delta flights
Southwest	PriceFrom $252	Free Cancellation	Rating 8.0 4,219 reviews	Search Southwest flights
American Airlines	PriceFrom $286	Free Cancellation	Rating 7.0 12,228 reviews	Search American Airlines flights

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West Seneca

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Angola

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Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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Cheap flights from Knoxville to Buffalo from $155

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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How to get the cheapest flight ticket from Knoxville to Buffalo

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What airlines fly to Buffalo?

When to book flights from Knoxville to Buffalo

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

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An easier way to manage your Buffalo trip

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