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Cheap flights from Knoxville to Buffalo from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 11/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:30 am - 11:45 amTYS-BUF
4h 15m1 stop
Delta Logo
6:03 am - 12:10 pmBUF-TYS
6h 07m1 stop
$277Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
4:04 pm - 11:35 pmTYS-BUF
7h 31m2 stops
American Airlines Logo
5:21 am - 11:03 amBUF-TYS
5h 42m1 stop
$282American Airlines
Find Deal
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
4:04 pm - 11:35 pmTYS-BUF
7h 31m2 stops
American Airlines Logo
11:24 am - 8:27 pmBUF-TYS
9h 03m2 stops
$287American Airlines
Find Deal
Wed, Feb 25 - Sat, Feb 28
Delta Logo
7:30 am - 11:45 amTYS-BUF
4h 15m1 stop
Delta Logo
6:25 am - 11:47 amBUF-TYS
5h 22m1 stop
$307Delta
Find Deal
Sat, Feb 28 - Sun, Mar 8
Delta Logo
7:30 am - 11:45 amTYS-BUF
4h 15m1 stop
Delta Logo
2:30 pm - 8:36 pmBUF-TYS
6h 06m1 stop
$337Delta
Find Deal
Sun, Mar 1 - Mon, Mar 9
United Airlines Logo
6:45 am - 5:50 pmTYS-BUF
11h 05m2 stops
United Airlines Logo
2:58 pm - 7:04 pmBUF-TYS
4h 06m1 stop
$342United Airlines
Find Deal
Mon, Mar 2 - Tue, Mar 10
American Airlines Logo
11:45 am - 4:54 pmTYS-BUF
5h 09m1 stop
American Airlines Logo
5:21 am - 11:03 amBUF-TYS
5h 42m1 stop
$347American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
United Airlines Logo
6:45 am - 2:13 pmTYS-BUF
7h 28m2 stops
United Airlines Logo
6:00 am - 1:20 pmBUF-TYS
7h 20m2 stops
$357United Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
Southwest Logo
7:50 am - 11:40 amTYS-BUF
3h 50m1 stop
Southwest Logo
12:25 pm - 10:00 pmBUF-TYS
9h 35m1 stop
$392Southwest
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Fri, Mar 6 - Sun, Mar 8
Southwest Logo
7:50 am - 3:15 pmTYS-BUF
7h 25m2 stops
Southwest Logo
12:25 pm - 10:00 pmBUF-TYS
9h 35m1 stop
$398Southwest
Find Deal
Fri, Mar 6 - Sun, Mar 8

Delta flights from Knoxville to Buffalo

Our best Delta deals on Knoxville to Buffalo flight tickets
Delta
Feb 18
TYS7:30 amKnoxville McGhee Tyson
4h 15m
1 stop
BUF11:45 amBuffalo
Feb 21
BUF6:03 amBuffalo
6h 07m
1 stop
TYS12:10 pmKnoxville McGhee Tyson
$277
Find similar
Delta
Feb 28
TYS7:30 amKnoxville McGhee Tyson
4h 15m
1 stop
BUF11:45 amBuffalo
Mar 8
BUF6:25 amBuffalo
5h 22m
1 stop
TYS11:47 amKnoxville McGhee Tyson
$307
Find similar
Delta
Mar 1
TYS7:30 amKnoxville McGhee Tyson
4h 15m
1 stop
BUF11:45 amBuffalo
Mar 9
BUF2:30 pmBuffalo
6h 06m
1 stop
TYS8:36 pmKnoxville McGhee Tyson
$337
Find similar

Southwest flights from Knoxville to Buffalo

Our best Southwest deals on Knoxville to Buffalo flight tickets
Southwest
Mar 6
TYS7:50 amKnoxville McGhee Tyson
3h 50m
1 stop
BUF11:40 amBuffalo
Mar 8
BUF12:25 pmBuffalo
9h 35m
1 stop
TYS10:00 pmKnoxville McGhee Tyson
$392
Find similar
Southwest
Mar 6
TYS7:50 amKnoxville McGhee Tyson
7h 25m
2 stops
BUF3:15 pmBuffalo
Mar 8
BUF12:25 pmBuffalo
9h 35m
1 stop
TYS10:00 pmKnoxville McGhee Tyson
$398
Find similar
Southwest
Mar 6
TYS7:50 amKnoxville McGhee Tyson
7h 25m
2 stops
BUF3:15 pmBuffalo
Mar 8
BUF6:00 amBuffalo
6h 55m
2 stops
TYS12:55 pmKnoxville McGhee Tyson
$407
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/18

7:30 am-11:45 am

1 stop4h 15m

Buffalo

Sat 2/21

6:03 am-12:10 pm

1 stop6h 07m

$277

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

4:04 pm-11:35 pm

2 stops7h 31m

Buffalo

Sat 2/28

5:21 am-11:03 am

1 stop5h 42m

$282

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

4:04 pm-11:35 pm

2 stops7h 31m

Buffalo

Sat 2/28

11:24 am-8:27 pm

2 stops9h 03m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 2/28

7:30 am-11:45 am

1 stop4h 15m

Buffalo

Sun 3/8

6:25 am-11:47 am

1 stop5h 22m

$307

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sun 3/1

7:30 am-11:45 am

1 stop4h 15m

Buffalo

Mon 3/9

2:30 pm-8:36 pm

1 stop6h 06m

$337

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 3/2

6:45 am-5:50 pm

2 stops11h 05m

Buffalo

Tue 3/10

2:58 pm-7:04 pm

1 stop4h 06m

$342

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/18

11:45 am-4:54 pm

1 stop5h 09m

Buffalo

Sat 2/21

5:21 am-11:03 am

1 stop5h 42m

$347

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/18

6:45 am-2:13 pm

2 stops7h 28m

Buffalo

Sat 2/21

6:00 am-1:20 pm

2 stops7h 20m

$357

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 3/6

7:50 am-11:40 am

1 stop3h 50m

Buffalo

Sun 3/8

12:25 pm-10:00 pm

1 stop9h 35m

$392

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 3/6

7:50 am-3:15 pm

2 stops7h 25m

Buffalo

Sun 3/8

12:25 pm-10:00 pm

1 stop9h 35m

$398

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of March, then book flights to Buffalo from Knoxville during June instead. Flights to Buffalo in June, while not as cheap as those in March, still average around $248.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Wednesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $248. Flights from Knoxville to Buffalo on a Monday will generally be more expensive and average around $513. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from Knoxville to Buffalo when you can find flight prices for as low as $283. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $407 per ticket.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Direct flights

None
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
Search flight deals

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 3h 50m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $232Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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