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Cheap flights from Knoxville to Buffalo from $156

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:25 pm - 11:40 am
TYS
-
BUF
19h 15m
2 stops
Multiple Airlines Logo
3:58 pm - 5:30 pm
BUF
-
TYS
25h 32m
1 stop
$275Multiple Airlines
Wed, Apr 22 - Sun, Apr 26
Multiple Airlines Logo
5:10 pm - 9:57 am
TYS
-
BUF
16h 47m
1 stop
Multiple Airlines Logo
12:32 pm - 9:40 am
BUF
-
TYS
21h 08m
2 stops
$289Multiple Airlines
Thu, Apr 16 - Mon, Apr 20
Delta Logo
5:26 pm - 10:39 pm
TYS
-
BUF
5h 13m
1 stop
Delta Logo
6:05 am - 10:21 am
BUF
-
TYS
4h 16m
1 stop
$311Delta
Thu, Apr 30 - Mon, May 4
Southwest Logo
6:40 am - 2:15 pm
TYS
-
BUF
7h 35m
1 stop
Southwest Logo
6:05 am - 5:10 pm
BUF
-
TYS
11h 05m
2 stops
$314Southwest
Sat, May 9 - Wed, May 13
Southwest Logo
8:05 am - 12:00 pm
TYS
-
BUF
3h 55m
1 stop
Southwest Logo
5:20 pm - 9:15 pm
BUF
-
TYS
3h 55m
1 stop
$321Southwest
Thu, Apr 16 - Mon, Apr 20
Southwest Logo
5:40 pm - 11:25 pm
TYS
-
BUF
5h 45m
2 stops
Southwest Logo
6:05 am - 5:10 pm
BUF
-
TYS
11h 05m
2 stops
$323Southwest
Sat, May 9 - Wed, May 13
Delta Logo
7:50 am - 11:39 am
TYS
-
BUF
3h 49m
1 stop
Delta Logo
6:05 am - 10:21 am
BUF
-
TYS
4h 16m
1 stop
$326Delta
Wed, Apr 22 - Sun, Apr 26
Southwest Logo
6:35 am - 3:25 pm
TYS
-
BUF
8h 50m
2 stops
Southwest Logo
12:40 pm - 8:20 pm
BUF
-
TYS
7h 40m
2 stops
$331Southwest
Thu, Apr 16 - Mon, Apr 20
Delta Logo
5:24 pm - 10:39 pm
TYS
-
BUF
5h 15m
1 stop
Delta Logo
6:05 am - 10:21 am
BUF
-
TYS
4h 16m
1 stop
$334Delta
Fri, May 1 - Mon, May 4
Multiple Airlines Logo
8:00 am - 6:46 pm
TYS
-
BUF
10h 46m
2 stops
Multiple Airlines Logo
8:49 pm - 5:30 pm
BUF
-
TYS
20h 41m
1 stop
$346Multiple Airlines
Fri, May 15 - Sun, May 17

American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets
American Airlines
Apr 14
TYS6:38 pmKnoxville McGhee Tyson
5h 11m
1 stop
BUF11:49 pmBuffalo
Apr 18
BUF5:42 pmBuffalo
6h 13m
2 stops
TYS11:55 pmKnoxville McGhee Tyson
$308
American Airlines
May 10
TYS6:00 amKnoxville McGhee Tyson
6h 13m
1 stop
BUF12:13 pmBuffalo
May 13
BUF5:30 amBuffalo
5h 31m
1 stop
TYS11:01 amKnoxville McGhee Tyson
$364
American Airlines
Apr 15
TYS6:00 amKnoxville McGhee Tyson
5h 58m
1 stop
BUF11:58 amBuffalo
Apr 15
BUF7:28 pmBuffalo
4h 27m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$383

Southwest flights from Knoxville to Buffalo

Our best Southwest deals on Knoxville to Buffalo flight tickets
Southwest
May 9
TYS6:40 amKnoxville McGhee Tyson
7h 35m
1 stop
BUF2:15 pmBuffalo
May 13
BUF6:05 amBuffalo
11h 05m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$314
Southwest
Apr 16
TYS8:05 amKnoxville McGhee Tyson
3h 55m
1 stop
BUF12:00 pmBuffalo
Apr 20
BUF5:20 pmBuffalo
3h 55m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
$321
Southwest
May 9
TYS5:40 pmKnoxville McGhee Tyson
5h 45m
2 stops
BUF11:25 pmBuffalo
May 13
BUF6:05 amBuffalo
11h 05m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$323

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 4/22

4:25 pm-11:40 am

2 stops19h 15m

Buffalo

Sun 4/26

3:58 pm-5:30 pm

1 stop25h 32m

$275

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 4/16

5:10 pm-9:57 am

1 stop16h 47m

Buffalo

Mon 4/20

12:32 pm-9:40 am

2 stops21h 08m

$289

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 4/30

5:26 pm-10:39 pm

1 stop5h 13m

Buffalo

Mon 5/4

6:05 am-10:21 am

1 stop4h 16m

$311

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 5/9

6:40 am-2:15 pm

1 stop7h 35m

Buffalo

Wed 5/13

6:05 am-5:10 pm

2 stops11h 05m

$314
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 4/16

8:05 am-12:00 pm

1 stop3h 55m

Buffalo

Mon 4/20

5:20 pm-9:15 pm

1 stop3h 55m

$321

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 5/9

5:40 pm-11:25 pm

2 stops5h 45m

Buffalo

Wed 5/13

6:05 am-5:10 pm

2 stops11h 05m

$323

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 4/22

7:50 am-11:39 am

1 stop3h 49m

Buffalo

Sun 4/26

6:05 am-10:21 am

1 stop4h 16m

$326

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 4/16

6:35 am-3:25 pm

2 stops8h 50m

Buffalo

Mon 4/20

12:40 pm-8:20 pm

2 stops7h 40m

$331

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 5/1

5:24 pm-10:39 pm

1 stop5h 15m

Buffalo

Mon 5/4

6:05 am-10:21 am

1 stop4h 16m

$334

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 5/15

8:00 am-6:46 pm

2 stops10h 46m

Buffalo

Sun 5/17

8:49 pm-5:30 pm

1 stop20h 41m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of June, then book flights to Buffalo from Knoxville during August instead. Flights to Buffalo in August, while not as cheap as those in June, still average around $253.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Fastest flight time

3h 41m

Direct flights

None
The fastest flight from Knoxville to Buffalo takes 3h 41m
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
Search flight deals

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 3h 41m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $232Free CancellationRating
7.9
8,303 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,480 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Orchard Park
Williamsville
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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