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Cheap flights from Knoxville to Buffalo from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 8/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:22 pm - 9:55 pm
TYS
-
BUF
5h 33m
1 stop
American Airlines Logo
6:30 am - 1:33 pm
BUF
-
TYS
7h 03m
1 stop
$233American Airlines
Wed, Sep 2 - Wed, Sep 9
Southwest Logo
8:05 am - 2:20 pm
TYS
-
BUF
6h 15m
1 stop
Southwest Logo
8:55 am - 6:55 pm
BUF
-
TYS
10h 00m
2 stops
$240Southwest
Wed, Sep 2 - Wed, Sep 9
Southwest Logo
7:00 am - 2:20 pm
TYS
-
BUF
7h 20m
2 stops
Southwest Logo
8:55 am - 6:55 pm
BUF
-
TYS
10h 00m
2 stops
$245Southwest
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
7:04 am - 11:29 am
TYS
-
BUF
4h 25m
1 stop
American Airlines Logo
4:49 pm - 10:58 pm
BUF
-
TYS
6h 09m
1 stop
$256American Airlines
Wed, Aug 12 - Mon, Aug 17
American Airlines Logo
6:50 pm - 11:59 pm
TYS
-
BUF
5h 09m
1 stop
American Airlines Logo
7:35 pm - 11:51 pm
BUF
-
TYS
4h 16m
1 stop
$279American Airlines
Tue, Jul 7 - Tue, Jul 14
Multiple Airlines Logo
12:40 pm - 11:33 am
TYS
-
BUF
22h 53m
2 stops
Multiple Airlines Logo
7:57 pm - 3:30 pm
BUF
-
TYS
19h 33m
1 stop
$280Multiple Airlines
Fri, Jul 10 - Mon, Jul 13
Multiple Airlines Logo
6:29 pm - 7:07 pm
TYS
-
BUF
24h 38m
1 stop
Multiple Airlines Logo
11:35 am - 6:35 pm
BUF
-
TYS
31h 00m
2 stops
$282Multiple Airlines
Mon, Aug 17 - Sun, Aug 23
Southwest Logo
12:45 pm - 10:45 pm
TYS
-
BUF
10h 00m
2 stops
Southwest Logo
4:25 pm - 9:20 pm
BUF
-
TYS
4h 55m
1 stop
$284Southwest
Tue, Jul 7 - Tue, Jul 14
Southwest Logo
7:00 am - 2:10 pm
TYS
-
BUF
7h 10m
2 stops
Southwest Logo
1:10 pm - 7:40 pm
BUF
-
TYS
6h 30m
1 stop
$286Southwest
Sat, Oct 17 - Sat, Oct 24
Southwest Logo
12:45 pm - 10:45 pm
TYS
-
BUF
10h 00m
2 stops
Southwest Logo
10:25 am - 9:20 pm
BUF
-
TYS
10h 55m
2 stops
$289Southwest
Tue, Jul 7 - Tue, Jul 14

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American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets
American Airlines
Sep 2
TYS4:22 pmKnoxville McGhee Tyson
5h 33m
1 stop
BUF9:55 pmBuffalo
Sep 9
BUF6:30 amBuffalo
7h 03m
1 stop
TYS1:33 pmKnoxville McGhee Tyson
$233
American Airlines
Aug 12
TYS7:04 amKnoxville McGhee Tyson
4h 25m
1 stop
BUF11:29 amBuffalo
Aug 17
BUF4:49 pmBuffalo
6h 09m
1 stop
TYS10:58 pmKnoxville McGhee Tyson
$256
American Airlines
Jul 7
TYS6:50 pmKnoxville McGhee Tyson
5h 09m
1 stop
BUF11:59 pmBuffalo
Jul 14
BUF7:35 pmBuffalo
4h 16m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$279

Southwest flights from Knoxville to Buffalo

Our best Southwest deals on Knoxville to Buffalo flight tickets
Southwest
Sep 2
TYS8:05 amKnoxville McGhee Tyson
6h 15m
1 stop
BUF2:20 pmBuffalo
Sep 9
BUF8:55 amBuffalo
10h 00m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$240
Southwest
Sep 2
TYS7:00 amKnoxville McGhee Tyson
7h 20m
2 stops
BUF2:20 pmBuffalo
Sep 9
BUF8:55 amBuffalo
10h 00m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$245
Southwest
Jul 7
TYS12:45 pmKnoxville McGhee Tyson
10h 00m
2 stops
BUF10:45 pmBuffalo
Jul 14
BUF4:25 pmBuffalo
4h 55m
1 stop
TYS9:20 pmKnoxville McGhee Tyson
$284

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 9/2

4:22 pm-9:55 pm

1 stop5h 33m

Buffalo

Wed 9/9

6:30 am-1:33 pm

1 stop7h 03m

$233

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 9/2

8:05 am-2:20 pm

1 stop6h 15m

Buffalo

Wed 9/9

8:55 am-6:55 pm

2 stops10h 00m

$240

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 9/2

7:00 am-2:20 pm

2 stops7h 20m

Buffalo

Wed 9/9

8:55 am-6:55 pm

2 stops10h 00m

$245

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 8/12

7:04 am-11:29 am

1 stop4h 25m

Buffalo

Mon 8/17

4:49 pm-10:58 pm

1 stop6h 09m

$256
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 7/7

6:50 pm-11:59 pm

1 stop5h 09m

Buffalo

Tue 7/14

7:35 pm-11:51 pm

1 stop4h 16m

$279

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 7/10

12:40 pm-11:33 am

2 stops22h 53m

Buffalo

Mon 7/13

7:57 pm-3:30 pm

1 stop19h 33m

$280

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-7:07 pm

1 stop24h 38m

Buffalo

Sun 8/23

11:35 am-6:35 pm

2 stops31h 00m

$282

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 7/7

12:45 pm-10:45 pm

2 stops10h 00m

Buffalo

Tue 7/14

4:25 pm-9:20 pm

1 stop4h 55m

$284

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 10/17

7:00 am-2:10 pm

2 stops7h 10m

Buffalo

Sat 10/24

1:10 pm-7:40 pm

1 stop6h 30m

$286

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 7/7

12:45 pm-10:45 pm

2 stops10h 00m

Buffalo

Tue 7/14

10:25 am-9:20 pm

2 stops10h 55m

$289

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Buffalo?

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of August, then book flights to Buffalo from Knoxville during November instead. Flights to Buffalo in November, while not as cheap as those in August, still average around $283.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Knoxville to Buffalo takes 4h 06m
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
Search flight deals

Frequently asked questions about flying from Knoxville to Buffalo

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 4h 06m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $159Free CancellationRating
7.9
8,396 reviews
Search Delta flights
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Grand Island
Orchard Park
Bowmansville
West Seneca
Lockport
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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