What is the cheapest airline that flies from Knoxville McGhee Tyson to Buffalo?

Delta, United Airlines, and Southwest are the most popular carriers operating from Knoxville McGhee Tyson to Buffalo

What airlines fly to Buffalo?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Buffalo from Knoxville according to our data. American Airlines is the first choice among our users, with 74% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 3 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

As of September 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$136 Cheap Flights from Knoxville to Buffalo in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Buffalo

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

5:40 am - 11:16 amTYS Knoxville McGhee Tyson-BUF Buffalo

5h 36m1 stop Atlanta Hartsfield-Jackson

3:53 pm - 9:37 pmBUF Buffalo-TYS Knoxville McGhee Tyson

5h 44m1 stop Detroit Metropolitan Wayne County

$239Delta

Sat, Oct 17 - Tue, Oct 20

5:40 am - 11:16 amTYS Knoxville McGhee Tyson-BUF Buffalo

5h 36m1 stop Atlanta Hartsfield-Jackson

6:15 am - 10:20 amBUF Buffalo-TYS Knoxville McGhee Tyson

4h 05m1 stop Detroit Metropolitan Wayne County

$239Delta

Sat, Oct 17 - Wed, Oct 21

6:00 am - 1:29 pmTYS Knoxville McGhee Tyson-BUF Buffalo

7h 29m1 stop New York LaGuardia

6:00 am - 11:02 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 02m1 stop New York LaGuardia

$271Delta

Fri, Oct 16 - Tue, Oct 20

9:41 pm - 12:59 pmTYS Knoxville McGhee Tyson-BUF Buffalo

15h 18m2 stops Tampa St. Petersburg Atlanta Hartsfield-Jackson

6:51 pm - 1:53 pmBUF Buffalo-TYS Knoxville McGhee Tyson

19h 02m1 stop Orlando

$278Multiple Airlines

Fri, Oct 16 - Tue, Oct 20

6:00 am - 12:46 pmTYS Knoxville McGhee Tyson-BUF Buffalo

6h 46m1 stop Philadelphia

7:53 pm - 11:55 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 02m1 stop Charlotte Douglas

$287American Airlines

Fri, Oct 16 - Mon, Oct 19

6:05 pm - 11:59 pmTYS Knoxville McGhee Tyson-BUF Buffalo

5h 54m1 stop Washington, D.C. Reagan-National

6:00 am - 10:25 amBUF Buffalo-TYS Knoxville McGhee Tyson

4h 25m1 stop Washington, D.C. Reagan-National

$287American Airlines

Fri, Oct 16 - Mon, Oct 19

10:42 am - 4:43 pmTYS Knoxville McGhee Tyson-BUF Buffalo

6h 01m1 stop Chicago O'Hare Intl

6:30 am - 2:42 pmBUF Buffalo-TYS Knoxville McGhee Tyson

8h 12m2 stops Newark Washington, D.C. Dulles Intl

$292United Airlines

Fri, Oct 16 - Wed, Oct 21

5:43 pm - 5:52 pmTYS Knoxville McGhee Tyson-BUF Buffalo

24h 09m1 stop Orlando Sanford Intl

1:44 pm - 11:29 amBUF Buffalo-TYS Knoxville McGhee Tyson

21h 45m2 stops Atlanta Hartsfield-Jackson Baltimore/Washington

$313Multiple Airlines

Sat, Oct 17 - Wed, Oct 21

7:25 pm - 8:15 amTYS Knoxville McGhee Tyson-BUF Buffalo

12h 50m2 stops Nashville Intl Baltimore/Washington

7:00 pm - 10:45 pmBUF Buffalo-TYS Knoxville McGhee Tyson

3h 45m1 stop Nashville Intl

$366Southwest

Fri, Oct 23 - Sun, Oct 25

7:25 pm - 8:15 amTYS Knoxville McGhee Tyson-BUF Buffalo

12h 50m2 stops Nashville Intl Baltimore/Washington

9:00 am - 7:05 pmBUF Buffalo-TYS Knoxville McGhee Tyson

10h 05m2 stops Baltimore/Washington Orlando

$421Southwest

Fri, Oct 23 - Sun, Oct 25

Cheap last minute flights

Enter your travel dates to find the best prices.

4:48 pm - 10:10 pmTYS Knoxville McGhee Tyson-BUF Buffalo

5h 22m1 stop Chicago O'Hare Intl

5:30 am - 11:26 amBUF Buffalo-TYS Knoxville McGhee Tyson

5h 56m1 stop Washington, D.C. Reagan-National

$609American Airlines

Tue, Sep 22 - Sat, Sep 26

9:45 am - 2:18 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 33m1 stop Washington, D.C. Dulles Intl

6:30 am - 5:08 pmBUF Buffalo-TYS Knoxville McGhee Tyson

10h 38m2 stops Newark Chicago O'Hare Intl

$614United Airlines

Tue, Sep 22 - Sat, Sep 26

12:45 pm - 9:10 pmTYS Knoxville McGhee Tyson-BUF Buffalo

8h 25m2 stops Orlando Baltimore/Washington

10:40 am - 5:45 pmBUF Buffalo-TYS Knoxville McGhee Tyson

7h 05m2 stops Orlando Nashville Intl

$619Southwest

Tue, Sep 22 - Sat, Sep 26

1:59 pm - 11:12 pmTYS Knoxville McGhee Tyson-BUF Buffalo

9h 13m2 stops Chicago O'Hare Intl Newark

6:30 am - 2:42 pmBUF Buffalo-TYS Knoxville McGhee Tyson

8h 12m2 stops Newark Washington, D.C. Dulles Intl

$619United Airlines

Tue, Sep 22 - Sat, Sep 26

1:10 pm - 7:02 pmTYS Knoxville McGhee Tyson-BUF Buffalo

5h 52m1 stop Washington, D.C. Dulles Intl

7:00 am - 1:14 pmBUF Buffalo-TYS Knoxville McGhee Tyson

6h 14m1 stop Chicago O'Hare Intl

$655United Airlines

Tue, Sep 22 - Thu, Sep 24

1:10 pm - 7:02 pmTYS Knoxville McGhee Tyson-BUF Buffalo

5h 52m1 stop Washington, D.C. Dulles Intl

10:10 am - 2:42 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 32m1 stop Washington, D.C. Dulles Intl

$655United Airlines

Tue, Sep 22 - Thu, Sep 24

8:05 am - 2:20 pmTYS Knoxville McGhee Tyson-BUF Buffalo

6h 15m1 stop Baltimore/Washington

9:40 am - 5:10 pmBUF Buffalo-TYS Knoxville McGhee Tyson

7h 30m2 stops Baltimore/Washington Orlando

$660Southwest

Tue, Sep 22 - Thu, Sep 24

6:00 am - 7:02 pmTYS Knoxville McGhee Tyson-BUF Buffalo

13h 02m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

10:10 am - 2:42 pmBUF Buffalo-TYS Knoxville McGhee Tyson

4h 32m1 stop Washington, D.C. Dulles Intl

$660United Airlines

Tue, Sep 22 - Thu, Sep 24

7:00 am - 3:15 pmTYS Knoxville McGhee Tyson-BUF Buffalo

8h 15m2 stops Nashville Intl Chicago Midway

9:40 am - 5:10 pmBUF Buffalo-TYS Knoxville McGhee Tyson

7h 30m2 stops Baltimore/Washington Orlando

$665Southwest

Tue, Sep 22 - Thu, Sep 24

8:05 am - 12:30 pmTYS Knoxville McGhee Tyson-BUF Buffalo

4h 25m1 stop Baltimore/Washington

12:30 pm - 7:10 pmBUF Buffalo-TYS Knoxville McGhee Tyson

6h 40m1 stop Nashville Intl

$678Southwest

Wed, Sep 23 - Fri, Sep 25

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American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets

American Airlines

Oct 16

TYS6:00 amKnoxville McGhee Tyson

6h 46m

1 stop

BUF12:46 pmBuffalo

Oct 19

BUF7:53 pmBuffalo

4h 02m

1 stop

TYS11:55 pmKnoxville McGhee Tyson

$287

American Airlines

Oct 16

TYS6:00 amKnoxville McGhee Tyson

6h 46m

1 stop

BUF12:46 pmBuffalo

Oct 19

BUF7:53 pmBuffalo

4h 02m

1 stop

TYS11:55 pmKnoxville McGhee Tyson

$301

American Airlines

Oct 23

TYS6:05 pmKnoxville McGhee Tyson

5h 54m

1 stop

BUF11:59 pmBuffalo

Oct 25

BUF7:53 pmBuffalo

4h 02m

1 stop

TYS11:55 pmKnoxville McGhee Tyson

$334

Delta flights from Knoxville to Buffalo

Our best Delta deals on Knoxville to Buffalo flight tickets

Delta

Oct 17

TYS5:40 amKnoxville McGhee Tyson

5h 36m

1 stop

BUF11:16 amBuffalo

Oct 20

BUF3:53 pmBuffalo

5h 44m

1 stop

TYS9:37 pmKnoxville McGhee Tyson

$239

Delta

Oct 16

TYS6:00 amKnoxville McGhee Tyson

7h 29m

1 stop

BUF1:29 pmBuffalo

Oct 20

BUF6:00 amBuffalo

5h 02m

1 stop

TYS11:02 amKnoxville McGhee Tyson

$271

Delta

Oct 16

TYS6:00 amKnoxville McGhee Tyson

7h 29m

1 stop

BUF1:29 pmBuffalo

Oct 19

BUF2:10 pmBuffalo

6h 59m

1 stop

TYS9:09 pmKnoxville McGhee Tyson

$297

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 10/17

5:40 am-11:16 am

1 stop5h 36m

Buffalo

Tue 10/20

3:53 pm-9:37 pm

1 stop5h 44m

$239

Quickest round-trip

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 10/17

5:40 am-11:16 am

1 stop5h 36m

Buffalo

Wed 10/21

6:15 am-10:20 am

1 stop4h 05m

$239

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/16

6:00 am-1:29 pm

1 stop7h 29m

Buffalo

Tue 10/20

6:00 am-11:02 am

1 stop5h 02m

$271

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/16

9:41 pm-12:59 pm

2 stops15h 18m

Buffalo

Tue 10/20

6:51 pm-1:53 pm

1 stop19h 02m

$278

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/16

6:00 am-12:46 pm

1 stop6h 46m

Buffalo

Mon 10/19

7:53 pm-11:55 pm

1 stop4h 02m

$287

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/16

6:05 pm-11:59 pm

1 stop5h 54m

Buffalo

Mon 10/19

6:00 am-10:25 am

1 stop4h 25m

$287

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/16

10:42 am-4:43 pm

1 stop6h 01m

Buffalo

Wed 10/21

6:30 am-2:42 pm

2 stops8h 12m

$292

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Sat 10/17

5:43 pm-5:52 pm

1 stop24h 09m

Buffalo

Wed 10/21

1:44 pm-11:29 am

2 stops21h 45m

$313

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/23

7:25 pm-8:15 am

2 stops12h 50m

Buffalo

Sun 10/25

7:00 pm-10:45 pm

1 stop3h 45m

$366

KnoxvilleBuffalo

TYS Knoxville McGhee Tyson - BUF Buffalo

TYSBUF

Knoxville McGhee Tyson

Fri 10/23

7:25 pm-8:15 am

2 stops12h 50m

Buffalo

Sun 10/25

9:00 am-7:05 pm

2 stops10h 05m

$421

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Knoxville and Buffalo?

Prices are currently low for flights on this route.

Typical prices usually range from $276 to $416.
The lowest price recently found on this route was $239.

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Knoxville during October instead. Flights to Buffalo in October, while not as cheap as those in November, still average around $317.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Best Price Found	$136
Fastest flight time	4h 24m
Direct flights	None

The best one-way flight to Buffalo from Knoxville in the past 72 hours is $136. The best round-trip flight deal from Knoxville to Buffalo found on momondo in the last 72 hours is $239.

The fastest flight from Knoxville to Buffalo takes 4h 24m

There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.

Search flight deals

Frequently asked questions about flying from Knoxville to Buffalo

How far is Knoxville McGhee Tyson to Buffalo by plane?
There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 4h 24m is a normal flight duration for this route.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?
As of September 2026, there are 3 operators available to choose from for flights from Knoxville McGhee Tyson Airport to Buffalo Airport.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Knoxville to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Knoxville to Buffalo is American Airlines, representing 64% of all bookings. The subsequent popular airlines are Southwest at 20% and Delta at 16%.

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $232	Free Cancellation	Rating 7.8 8,591 reviews	Search Delta flights
American Airlines	PriceFrom $268	Free Cancellation	Rating 7.0 12,086 reviews	Search American Airlines flights
Southwest	PriceFrom $316	Free Cancellation	Rating 8.0 4,196 reviews	Search Southwest flights

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West Seneca

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Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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Cheap flights from Knoxville to Buffalo from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 11/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Knoxville to Buffalo

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How to get the cheapest flight ticket from Knoxville to Buffalo

What is the typical price of a round-trip flight between Knoxville and Buffalo?

What is the cheapest month to fly to Buffalo?

What is the cheapest airline that flies from Knoxville McGhee Tyson to Buffalo?

What airlines fly to Buffalo?

When to book flights from Knoxville to Buffalo

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

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Frequently asked questions about flying from Knoxville to Buffalo

Best airlines flying from Knoxville to Buffalo

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An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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