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Cheap flights from Knoxville to Buffalo from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 2/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:38 am - 11:43 am
TYS
-
BUF
4h 05m
1 stop
Delta Logo
6:15 am - 12:08 pm
BUF
-
TYS
5h 53m
1 stop
$277Delta
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
7:12 am - 3:25 pm
TYS
-
BUF
8h 13m
2 stops
American Airlines Logo
11:23 am - 4:15 pm
BUF
-
TYS
4h 52m
1 stop
$282American Airlines
Wed, Feb 25 - Sat, Feb 28
American Airlines Logo
11:31 am - 5:14 pm
TYS
-
BUF
5h 43m
1 stop
American Airlines Logo
11:36 am - 5:48 pm
BUF
-
TYS
6h 12m
1 stop
$287American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
5:06 pm - 9:30 pm
TYS
-
BUF
4h 24m
1 stop
American Airlines Logo
5:26 pm - 11:55 pm
BUF
-
TYS
6h 29m
2 stops
$292American Airlines
Tue, Apr 7 - Sat, Apr 11
Southwest Logo
7:05 am - 2:35 pm
TYS
-
BUF
7h 30m
2 stops
Southwest Logo
8:00 am - 6:30 pm
BUF
-
TYS
10h 30m
2 stops
$323Southwest
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
7:12 am - 3:25 pm
TYS
-
BUF
8h 13m
2 stops
American Airlines Logo
7:00 am - 2:29 pm
BUF
-
TYS
7h 29m
2 stops
$329American Airlines
Wed, Feb 25 - Sat, Feb 28
Southwest Logo
7:50 am - 5:35 pm
TYS
-
BUF
9h 45m
1 stop
Southwest Logo
12:40 pm - 9:00 pm
BUF
-
TYS
8h 20m
1 stop
$358Southwest
Fri, Mar 20 - Sun, Mar 22
Southwest Logo
7:50 am - 3:15 pm
TYS
-
BUF
7h 25m
2 stops
Southwest Logo
12:40 pm - 9:00 pm
BUF
-
TYS
8h 20m
1 stop
$368Southwest
Fri, Mar 20 - Sun, Mar 22
United Airlines Logo
2:21 pm - 11:44 pm
TYS
-
BUF
9h 23m
1 stop
United Airlines Logo
6:07 am - 3:15 pm
BUF
-
TYS
9h 08m
1 stop
$374United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
7:25 pm - 6:46 pm
TYS
-
BUF
23h 21m
1 stop
United Airlines Logo
6:07 am - 10:49 am
BUF
-
TYS
4h 42m
1 stop
$382United Airlines
Sat, Feb 14 - Wed, Feb 18

Southwest flights from Knoxville to Buffalo

Our best Southwest deals on Knoxville to Buffalo flight tickets
Southwest
Apr 7
TYS7:05 amKnoxville McGhee Tyson
7h 30m
2 stops
BUF2:35 pmBuffalo
Apr 11
BUF8:00 amBuffalo
10h 30m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
$323
Southwest
Mar 20
TYS7:50 amKnoxville McGhee Tyson
9h 45m
1 stop
BUF5:35 pmBuffalo
Mar 22
BUF12:40 pmBuffalo
8h 20m
1 stop
TYS9:00 pmKnoxville McGhee Tyson
$358
Southwest
Mar 20
TYS7:50 amKnoxville McGhee Tyson
7h 25m
2 stops
BUF3:15 pmBuffalo
Mar 22
BUF12:40 pmBuffalo
8h 20m
1 stop
TYS9:00 pmKnoxville McGhee Tyson
$368

United Airlines flights from Knoxville to Buffalo

Our best United Airlines deals on Knoxville to Buffalo flight tickets
United Airlines
Feb 14
TYS2:21 pmKnoxville McGhee Tyson
9h 23m
1 stop
BUF11:44 pmBuffalo
Feb 18
BUF6:07 amBuffalo
9h 08m
1 stop
TYS3:15 pmKnoxville McGhee Tyson
$374
United Airlines
Feb 14
TYS7:25 pmKnoxville McGhee Tyson
23h 21m
1 stop
BUF6:46 pmBuffalo
Feb 18
BUF6:07 amBuffalo
4h 42m
1 stop
TYS10:49 amKnoxville McGhee Tyson
$382
United Airlines
Feb 14
TYS9:40 amKnoxville McGhee Tyson
9h 26m
1 stop
BUF7:06 pmBuffalo
Feb 18
BUF6:07 amBuffalo
7h 08m
2 stops
TYS1:15 pmKnoxville McGhee Tyson
$387

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

7:38 am-11:43 am

1 stop4h 05m

Buffalo

Sat 2/28

6:15 am-12:08 pm

1 stop5h 53m

$277

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

7:12 am-3:25 pm

2 stops8h 13m

Buffalo

Sat 2/28

11:23 am-4:15 pm

1 stop4h 52m

$282

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 4/7

11:31 am-5:14 pm

1 stop5h 43m

Buffalo

Sat 4/11

11:36 am-5:48 pm

1 stop6h 12m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 4/7

5:06 pm-9:30 pm

1 stop4h 24m

Buffalo

Sat 4/11

5:26 pm-11:55 pm

2 stops6h 29m

$292

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 4/7

7:05 am-2:35 pm

2 stops7h 30m

Buffalo

Sat 4/11

8:00 am-6:30 pm

2 stops10h 30m

$323

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 2/25

7:12 am-3:25 pm

2 stops8h 13m

Buffalo

Sat 2/28

7:00 am-2:29 pm

2 stops7h 29m

$329

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 3/20

7:50 am-5:35 pm

1 stop9h 45m

Buffalo

Sun 3/22

12:40 pm-9:00 pm

1 stop8h 20m

$358

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 3/20

7:50 am-3:15 pm

2 stops7h 25m

Buffalo

Sun 3/22

12:40 pm-9:00 pm

1 stop8h 20m

$368

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 2/14

2:21 pm-11:44 pm

1 stop9h 23m

Buffalo

Wed 2/18

6:07 am-3:15 pm

1 stop9h 08m

$374

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 2/14

7:25 pm-6:46 pm

1 stop23h 21m

Buffalo

Wed 2/18

6:07 am-10:49 am

1 stop4h 42m

$382

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of March, then book flights to Buffalo from Knoxville during June instead. Flights to Buffalo in June, while not as cheap as those in March, still average around $248.

How have Knoxville to Buffalo flight prices changed over time?

As of January 2026, prices for Knoxville to Buffalo flights are approximately 50% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Knoxville to Buffalo takes 4h 00m
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
Search flight deals

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 4h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $164Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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