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Cheap flights from Knoxville to Buffalo from $110

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 6/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:24 pm - 1:54 pm
TYS
-
BUF
42h 30m
2 stops
Multiple Airlines Logo
7:52 pm - 4:10 pm
BUF
-
TYS
20h 18m
1 stop
$284Multiple Airlines
Mon, May 25 - Mon, Jun 1
American Airlines Logo
6:38 pm - 11:49 pm
TYS
-
BUF
5h 11m
1 stop
American Airlines Logo
7:28 pm - 11:55 pm
BUF
-
TYS
4h 27m
1 stop
$295American Airlines
Tue, May 19 - Wed, May 20
Southwest Logo
12:50 pm - 10:15 pm
TYS
-
BUF
9h 25m
2 stops
Southwest Logo
4:00 pm - 8:50 pm
BUF
-
TYS
4h 50m
1 stop
$300Southwest
Wed, May 27 - Tue, Jun 2
Delta Logo
5:40 am - 11:23 am
TYS
-
BUF
5h 43m
1 stop
Delta Logo
4:55 pm - 11:56 pm
BUF
-
TYS
7h 01m
1 stop
$303Delta
Sat, May 16 - Tue, May 19
Southwest Logo
12:50 pm - 10:15 pm
TYS
-
BUF
9h 25m
2 stops
Southwest Logo
6:05 am - 5:10 pm
BUF
-
TYS
11h 05m
2 stops
$305Southwest
Wed, May 27 - Tue, Jun 2
Multiple Airlines Logo
12:56 pm - 10:39 am
TYS
-
BUF
21h 43m
2 stops
Multiple Airlines Logo
8:57 pm - 7:05 pm
BUF
-
TYS
22h 08m
1 stop
$313Multiple Airlines
Wed, Aug 12 - Sun, Aug 23
American Airlines Logo
6:07 pm - 10:35 pm
TYS
-
BUF
4h 28m
1 stop
American Airlines Logo
12:49 pm - 5:48 pm
BUF
-
TYS
4h 59m
1 stop
$326American Airlines
Fri, Jun 12 - Wed, Jun 17
Southwest Logo
12:45 pm - 10:40 pm
TYS
-
BUF
9h 55m
2 stops
Southwest Logo
2:40 pm - 9:20 pm
BUF
-
TYS
6h 40m
1 stop
$331Southwest
Tue, Jun 16 - Sat, Jun 20
Southwest Logo
7:05 am - 4:35 pm
TYS
-
BUF
9h 30m
2 stops
Southwest Logo
11:55 am - 5:10 pm
BUF
-
TYS
5h 15m
1 stop
$332Southwest
Tue, May 19 - Wed, May 20
Southwest Logo
12:45 pm - 10:40 pm
TYS
-
BUF
9h 55m
2 stops
Southwest Logo
6:00 am - 2:05 pm
BUF
-
TYS
8h 05m
2 stops
$336Southwest
Tue, Jun 16 - Sat, Jun 20

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Delta flights from Knoxville to Buffalo

Our best Delta deals on Knoxville to Buffalo flight tickets
Delta
May 16
TYS5:40 amKnoxville McGhee Tyson
5h 43m
1 stop
BUF11:23 amBuffalo
May 19
BUF4:55 pmBuffalo
7h 01m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$303
Delta
Oct 16
TYS7:20 pmKnoxville McGhee Tyson
4h 35m
1 stop
BUF11:55 pmBuffalo
Oct 19
BUF4:30 pmBuffalo
5h 15m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
$357
Delta
Oct 1
TYS7:20 pmKnoxville McGhee Tyson
4h 38m
1 stop
BUF11:58 pmBuffalo
Oct 4
BUF7:40 pmBuffalo
4h 07m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$377

American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets
American Airlines
May 19
TYS6:38 pmKnoxville McGhee Tyson
5h 11m
1 stop
BUF11:49 pmBuffalo
May 20
BUF7:28 pmBuffalo
4h 27m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$295
American Airlines
Jun 12
TYS6:07 pmKnoxville McGhee Tyson
4h 28m
1 stop
BUF10:35 pmBuffalo
Jun 17
BUF12:49 pmBuffalo
4h 59m
1 stop
TYS5:48 pmKnoxville McGhee Tyson
$326
American Airlines
Jul 17
TYS6:07 pmKnoxville McGhee Tyson
4h 45m
1 stop
BUF10:52 pmBuffalo
Jul 19
BUF6:00 amBuffalo
4h 38m
1 stop
TYS10:38 amKnoxville McGhee Tyson
$397

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 5/25

7:24 pm-1:54 pm

2 stops42h 30m

Buffalo

Mon 6/1

7:52 pm-4:10 pm

1 stop20h 18m

$284

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 5/19

6:38 pm-11:49 pm

1 stop5h 11m

Buffalo

Wed 5/20

7:28 pm-11:55 pm

1 stop4h 27m

$295

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 5/27

12:50 pm-10:15 pm

2 stops9h 25m

Buffalo

Tue 6/2

4:00 pm-8:50 pm

1 stop4h 50m

$300

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 5/16

5:40 am-11:23 am

1 stop5h 43m

Buffalo

Tue 5/19

4:55 pm-11:56 pm

1 stop7h 01m

$303

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 5/27

12:50 pm-10:15 pm

2 stops9h 25m

Buffalo

Tue 6/2

6:05 am-5:10 pm

2 stops11h 05m

$305

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Wed 8/12

12:56 pm-10:39 am

2 stops21h 43m

Buffalo

Sun 8/23

8:57 pm-7:05 pm

1 stop22h 08m

$313
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Fri 6/12

6:07 pm-10:35 pm

1 stop4h 28m

Buffalo

Wed 6/17

12:49 pm-5:48 pm

1 stop4h 59m

$326

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 6/16

12:45 pm-10:40 pm

2 stops9h 55m

Buffalo

Sat 6/20

2:40 pm-9:20 pm

1 stop6h 40m

$331

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 5/19

7:05 am-4:35 pm

2 stops9h 30m

Buffalo

Wed 5/20

11:55 am-5:10 pm

1 stop5h 15m

$332

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 6/16

12:45 pm-10:40 pm

2 stops9h 55m

Buffalo

Sat 6/20

6:00 am-2:05 pm

2 stops8h 05m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Buffalo?

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of June, then book flights to Buffalo from Knoxville during August instead. Flights to Buffalo in August, while not as cheap as those in June, still average around $253.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Fastest flight time

4h 13m

Direct flights

None
The fastest flight from Knoxville to Buffalo takes 4h 13m
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
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Frequently asked questions about flying from Knoxville to Buffalo

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 4h 13m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $159Free CancellationRating
7.9
8,463 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,681 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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