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Cheap flights from Knoxville to Buffalo from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Buffalo departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:55 pm - 10:29 am
TYS
-
BUF
21h 34m
2 stops
Multiple Airlines Logo
9:29 pm - 10:56 pm
BUF
-
TYS
25h 27m
1 stop
$260Multiple Airlines
Thu, Aug 27 - Thu, Sep 3
Delta Logo
7:33 am - 11:22 am
TYS
-
BUF
3h 49m
1 stop
Delta Logo
6:05 am - 11:18 am
BUF
-
TYS
5h 13m
1 stop
$287Delta
Sat, Sep 19 - Tue, Sep 22
American Airlines Logo
6:32 pm - 11:56 pm
TYS
-
BUF
5h 24m
1 stop
American Airlines Logo
4:49 pm - 10:58 pm
BUF
-
TYS
6h 09m
1 stop
$287American Airlines
Thu, Aug 27 - Thu, Sep 3
American Airlines Logo
7:31 pm - 11:36 pm
TYS
-
BUF
4h 05m
1 stop
American Airlines Logo
5:00 am - 10:45 am
BUF
-
TYS
5h 45m
1 stop
$287American Airlines
Mon, Aug 24 - Mon, Aug 31
Delta Logo
11:45 am - 3:13 pm
TYS
-
BUF
3h 28m
1 stop
Delta Logo
6:20 am - 10:18 am
BUF
-
TYS
3h 58m
1 stop
$287Delta
Sat, Sep 19 - Tue, Sep 22
Delta Logo
6:00 am - 11:23 am
TYS
-
BUF
5h 23m
1 stop
Delta Logo
7:05 pm - 11:57 pm
BUF
-
TYS
4h 52m
1 stop
$287Delta
Thu, Dec 3 - Mon, Dec 7
Multiple Airlines Logo
5:33 pm - 5:49 pm
TYS
-
BUF
24h 16m
1 stop
Multiple Airlines Logo
1:40 pm - 8:35 am
BUF
-
TYS
18h 55m
2 stops
$288Multiple Airlines
Mon, Sep 28 - Fri, Oct 2
Multiple Airlines Logo
12:55 pm - 10:29 am
TYS
-
BUF
21h 34m
2 stops
Multiple Airlines Logo
6:54 pm - 2:35 pm
BUF
-
TYS
19h 41m
1 stop
$288Multiple Airlines
Thu, Aug 20 - Mon, Aug 24
Southwest Logo
8:05 am - 2:20 pm
TYS
-
BUF
6h 15m
1 stop
Southwest Logo
8:55 am - 6:55 pm
BUF
-
TYS
10h 00m
2 stops
$292Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
1:00 pm - 9:55 pm
TYS
-
BUF
8h 55m
2 stops
Southwest Logo
6:00 am - 5:10 pm
BUF
-
TYS
11h 10m
1 stop
$298Southwest
Thu, Sep 10 - Mon, Sep 14

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Southwest flights from Knoxville to Buffalo

Our best Southwest deals on Knoxville to Buffalo flight tickets
Southwest
Aug 18
TYS8:05 amKnoxville McGhee Tyson
6h 15m
1 stop
BUF2:20 pmBuffalo
Aug 25
BUF8:55 amBuffalo
10h 00m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$292
Southwest
Sep 10
TYS1:00 pmKnoxville McGhee Tyson
8h 55m
2 stops
BUF9:55 pmBuffalo
Sep 14
BUF6:00 amBuffalo
11h 10m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
$298
Southwest
Sep 11
TYS1:00 pmKnoxville McGhee Tyson
8h 55m
2 stops
BUF9:55 pmBuffalo
Sep 14
BUF6:00 amBuffalo
11h 10m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
$299

American Airlines flights from Knoxville to Buffalo

Our best American Airlines deals on Knoxville to Buffalo flight tickets
American Airlines
Aug 19
TYS6:05 pmKnoxville McGhee Tyson
3h 50m
1 stop
BUF9:55 pmBuffalo
Aug 23
BUF7:54 pmBuffalo
4h 05m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$347
American Airlines
Aug 28
TYS6:05 pmKnoxville McGhee Tyson
3h 50m
1 stop
BUF9:55 pmBuffalo
Sep 4
BUF4:49 pmBuffalo
4h 10m
1 stop
TYS8:59 pmKnoxville McGhee Tyson
$349
American Airlines
Aug 11
TYS11:15 amKnoxville McGhee Tyson
5h 53m
1 stop
BUF5:08 pmBuffalo
Aug 15
BUF1:03 pmBuffalo
5h 11m
1 stop
TYS6:14 pmKnoxville McGhee Tyson
$447

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Knoxville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 8/27

12:55 pm-10:29 am

2 stops21h 34m

Buffalo

Thu 9/3

9:29 pm-10:56 pm

1 stop25h 27m

$260

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 9/19

7:33 am-11:22 am

1 stop3h 49m

Buffalo

Tue 9/22

6:05 am-11:18 am

1 stop5h 13m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 8/27

6:32 pm-11:56 pm

1 stop5h 24m

Buffalo

Thu 9/3

4:49 pm-10:58 pm

1 stop6h 09m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 8/24

7:31 pm-11:36 pm

1 stop4h 05m

Buffalo

Mon 8/31

5:00 am-10:45 am

1 stop5h 45m

$287
Quickest round-trip

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Sat 9/19

11:45 am-3:13 pm

1 stop3h 28m

Buffalo

Tue 9/22

6:20 am-10:18 am

1 stop3h 58m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 12/3

6:00 am-11:23 am

1 stop5h 23m

Buffalo

Mon 12/7

7:05 pm-11:57 pm

1 stop4h 52m

$287

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Mon 9/28

5:33 pm-5:49 pm

1 stop24h 16m

Buffalo

Fri 10/2

1:40 pm-8:35 am

2 stops18h 55m

$288

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 8/20

12:55 pm-10:29 am

2 stops21h 34m

Buffalo

Mon 8/24

6:54 pm-2:35 pm

1 stop19h 41m

$288

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Tue 8/18

8:05 am-2:20 pm

1 stop6h 15m

Buffalo

Tue 8/25

8:55 am-6:55 pm

2 stops10h 00m

$292

KnoxvilleBuffalo

TYS - BUF

TYSBUF

Knoxville McGhee Tyson

Thu 9/10

1:00 pm-9:55 pm

2 stops8h 55m

Buffalo

Mon 9/14

6:00 am-5:10 pm

1 stop11h 10m

$298

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Knoxville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Knoxville during August instead. Flights to Buffalo in August, while not as cheap as those in November, still average around $312.

When to book flights from Knoxville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Buffalo (TYS to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Buffalo

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Knoxville to Buffalo takes 3h 50m
There are no direct flights from Knoxville to Buffalo. There are no popular flight routes from Knoxville to Buffalo.
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Frequently asked questions about flying from Knoxville to Buffalo

  • How far is Knoxville McGhee Tyson to Buffalo by plane?

    There are 548.4 mi between Knoxville McGhee Tyson and Buffalo. 3h 50m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Buffalo Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Buffalo?

Best airlines flying from Knoxville to Buffalo

Compare and see reviews for airlines that fly from Knoxville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $159Free CancellationRating
7.8
8,487 reviews
Search Delta flights
American AirlinesPriceFrom $253Free CancellationRating
7.1
11,842 reviews
Search American Airlines flights
SouthwestPriceFrom $316Free CancellationRating
8.0
4,227 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Buffalo?

It is quick and easy to find Knoxville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Knoxville to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Knoxville.

I’m not ready to book a flight from Knoxville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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