Cheap flights from Jacksonville to St. Louis from $42

In general, October is the cheapest month to fly from Jacksonville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $317. The month of April is another great option to travel to St. Louis, with average flight prices from Jacksonville averaging around $350.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $397. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $447. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Jacksonville at noon is the least expensive time of day to depart. momondo users have found prices as low as $370 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $440 per ticket.

Fly from Jacksonville to Lambert-St Louis for the best Jacksonville - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Jacksonville when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $373 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Jacksonville for as low as $296 on momondo.

There is only 1 cabin class available to choose from on Jacksonville to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 72% on your flight if you consider stops on a Jacksonville to St. Louis flight.

As of September 2026, prices for Jacksonville to St. Louis flights are approximately 34% more expensive when compared to flights at the same time last year.

Southwest, United Airlines, and Delta are the most popular carriers operating from Jacksonville to Lambert-St Louis

Southwest, Delta and American Airlines are the top three most popular airlines that fly to St. Louis from Jacksonville according to our data. Southwest is the first choice among our users, with 52% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.