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Cheap flights from Islip, New York to Knoxville from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Islip, New York to Knoxville departing on 9/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Islip, New York to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:15 pm - 7:25 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
4h 10m1 stop Baltimore/Washington
Southwest Logo
1:00 pm - 9:35 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
8h 35m1 stop Orlando
$224Southwest
Sat, Sep 5 - Fri, Sep 11
Southwest Logo
3:15 pm - 7:25 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
4h 10m1 stop Baltimore/Washington
Southwest Logo
1:00 pm - 10:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
9h 10m2 stops Orlando Baltimore/Washington
$229Southwest
Sat, Sep 5 - Fri, Sep 11
Southwest Logo
6:15 am - 4:45 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
10h 30m2 stops Baltimore/Washington Orlando
Southwest Logo
8:20 am - 12:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
3h 50m1 stop Baltimore/Washington
$246Southwest
Sat, Oct 3 - Tue, Oct 6
Southwest Logo
12:20 pm - 7:35 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
7h 15m1 stop Baltimore/Washington
Southwest Logo
8:20 am - 12:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
3h 50m1 stop Baltimore/Washington
$246Southwest
Sat, Oct 3 - Tue, Oct 6
Southwest Logo
6:15 am - 4:45 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
10h 30m2 stops Baltimore/Washington Orlando
Southwest Logo
1:00 pm - 10:35 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
9h 35m2 stops Orlando Baltimore/Washington
$251Southwest
Sat, Oct 3 - Tue, Oct 6
Southwest Logo
3:20 pm - 7:55 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
4h 35m1 stop Baltimore/Washington
Southwest Logo
8:05 am - 12:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
4h 05m1 stop Baltimore/Washington
$252Southwest
Wed, Sep 9 - Tue, Sep 15
Southwest Logo
3:20 pm - 7:55 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
4h 35m1 stop Baltimore/Washington
Southwest Logo
12:45 pm - 9:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
8h 25m2 stops Orlando Baltimore/Washington
$258Southwest
Wed, Sep 9 - Tue, Sep 15
Multiple Airlines Logo
10:57 am - 10:56 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
11h 59m1 stop Orlando
Multiple Airlines Logo
8:30 am - 9:53 amTYS  Knoxville McGhee Tyson-ISP Islip Long Island
25h 23m1 stop Orlando Sanford Intl
$309Multiple Airlines
Fri, Sep 4 - Mon, Sep 7
Multiple Airlines Logo
7:09 pm - 7:05 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
23h 56m1 stop Orlando
Multiple Airlines Logo
2:49 pm - 9:53 amTYS  Knoxville McGhee Tyson-ISP Islip Long Island
19h 04m1 stop Orlando
$315Multiple Airlines
Thu, Aug 27 - Mon, Aug 31
Southwest Logo
5:30 am - 2:40 pmISP  Islip Long Island-TYS Knoxville McGhee Tyson
9h 10m2 stops Baltimore/Washington Orlando
Southwest Logo
1:00 pm - 10:10 pmTYS  Knoxville McGhee Tyson-ISP Islip Long Island
9h 10m2 stops Orlando Baltimore/Washington
$326Southwest
Sat, Sep 5 - Fri, Sep 11

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Southwest flights from Islip, New York to Knoxville

Our best Southwest deals on Islip, New York to Knoxville flight tickets
Southwest
Sep 5
ISP3:15 pmIslip Long Island
4h 10m
1 stop
TYS7:25 pmKnoxville McGhee Tyson
Sep 11
TYS1:00 pmKnoxville McGhee Tyson
8h 35m
1 stop
ISP9:35 pmIslip Long Island
$224
Southwest
Sep 5
ISP3:15 pmIslip Long Island
4h 10m
1 stop
TYS7:25 pmKnoxville McGhee Tyson
Sep 11
TYS1:00 pmKnoxville McGhee Tyson
9h 10m
2 stops
ISP10:10 pmIslip Long Island
$229
Southwest
Oct 3
ISP12:20 pmIslip Long Island
7h 15m
1 stop
TYS7:35 pmKnoxville McGhee Tyson
Oct 6
TYS8:20 amKnoxville McGhee Tyson
3h 50m
1 stop
ISP12:10 pmIslip Long Island
$246

momondo Fare Finder

 
Customize your flight search to find flights from Islip, New York to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Islip, New York to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 9/5

3:15 pm-7:25 pm

1 stop4h 10m

Knoxville McGhee Tyson

Fri 9/11

1:00 pm-9:35 pm

1 stop8h 35m

$224

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 9/5

3:15 pm-7:25 pm

1 stop4h 10m

Knoxville McGhee Tyson

Fri 9/11

1:00 pm-10:10 pm

2 stops9h 10m

$229

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 10/3

6:15 am-4:45 pm

2 stops10h 30m

Knoxville McGhee Tyson

Tue 10/6

8:20 am-12:10 pm

1 stop3h 50m

$246

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 10/3

12:20 pm-7:35 pm

1 stop7h 15m

Knoxville McGhee Tyson

Tue 10/6

8:20 am-12:10 pm

1 stop3h 50m

$246

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 10/3

6:15 am-4:45 pm

2 stops10h 30m

Knoxville McGhee Tyson

Tue 10/6

1:00 pm-10:35 pm

2 stops9h 35m

$251
Quickest round-trip

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Wed 9/9

3:20 pm-7:55 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 9/15

8:05 am-12:10 pm

1 stop4h 05m

$252

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Wed 9/9

3:20 pm-7:55 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 9/15

12:45 pm-9:10 pm

2 stops8h 25m

$258

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Fri 9/4

10:57 am-10:56 pm

1 stop11h 59m

Knoxville McGhee Tyson

Mon 9/7

8:30 am-9:53 am

1 stop25h 23m

$309

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Thu 8/27

7:09 pm-7:05 pm

1 stop23h 56m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-9:53 am

1 stop19h 04m

$315

IslipKnoxville

ISP Islip Long Island - TYS Knoxville McGhee Tyson

ISPTYS

Islip Long Island

Sat 9/5

5:30 am-2:40 pm

2 stops9h 10m

Knoxville McGhee Tyson

Fri 9/11

1:00 pm-10:10 pm

2 stops9h 10m

$326

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Islip, New York to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Islip, New York to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $299. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Islip, New York to Knoxville for around $596.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Islip, New York to Knoxville when you can find flight prices for as low as $344. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $512.

When to book flights from Islip, New York to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip, New York to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Islip, New York to Knoxville (ISP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Knoxville

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Islip, New York to Knoxville takes 3h 50m
There are no direct flights from Islip, New York to Knoxville. There are no popular flight routes from Islip, New York to Knoxville.
Search flight deals

Frequently asked questions about flying from Islip, New York to Knoxville

  • How far is Islip Long Island to Knoxville McGhee Tyson by plane?

    A flight from Islip Long Island to Knoxville McGhee Tyson will travel around 666.2 mi. In terms of flight time, this usually takes a little over 3h 50m.

  • When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Islip, New York to Knoxville?

Best airlines flying from Islip, New York to Knoxville

Compare and see reviews for airlines that fly from Islip, New York to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $256Free CancellationRating
8.0
4,220 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Islip to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Islip to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Islip to Knoxville with flexible booking policies on momondo?

All flight searches from Islip to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Knoxville?

momondo helps you find the best flight between Islip and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Islip to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Islip to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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