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Fly to
Route
Depart
Return
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Thu 1/7
3:50 pm-7:45 pm
1 stop3h 55m
Knoxville McGhee Tyson
Tue 1/12
1:15 pm-8:10 pm
1 stop6h 55m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Thu 1/7
5:45 am-5:10 pm
2 stops11h 25m
Knoxville McGhee Tyson
Tue 1/12
1:15 pm-8:10 pm
1 stop6h 55m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Thu 1/7
5:45 am-5:10 pm
2 stops11h 25m
Knoxville McGhee Tyson
Tue 1/12
1:15 pm-9:30 pm
2 stops8h 15m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Wed 11/4
4:05 pm-8:50 pm
1 stop4h 45m
Knoxville McGhee Tyson
Wed 11/11
7:55 am-4:15 pm
1 stop8h 20m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Wed 11/11
4:05 pm-8:50 pm
1 stop4h 45m
Knoxville McGhee Tyson
Sat 11/14
8:15 am-2:55 pm
1 stop6h 40m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Wed 11/4
4:05 pm-8:50 pm
1 stop4h 45m
Knoxville McGhee Tyson
Wed 11/11
1:00 pm-9:45 pm
2 stops8h 45m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Wed 11/11
12:30 pm-7:50 pm
2 stops7h 20m
Knoxville McGhee Tyson
Sat 11/14
8:15 am-12:05 pm
1 stop3h 50m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Mon 11/9
5:40 pm-9:45 pm
1 stop4h 05m
Knoxville McGhee Tyson
Fri 11/13
12:50 pm-11:35 pm
2 stops10h 45m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Tue 10/20
1:38 pm-1:53 pm
2 stops24h 15m
Knoxville McGhee Tyson
Wed 10/28
2:43 pm-5:31 pm
1 stop26h 48m
IslipKnoxville
ISP Islip Long Island - TYS Knoxville McGhee Tyson
ISPTYS
Islip Long Island
Sun 10/25
6:25 pm-11:14 am
1 stop16h 49m
Knoxville McGhee Tyson
Thu 10/29
7:00 am-5:31 pm
1 stop10h 31m
See travel insights to Knoxville from
How to get the cheapest flight ticket from Islip, New York to Knoxville
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest day to depart on your flight to Knoxville?
The cheapest day to depart from Islip, New York to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $327. When flying out on a Tuesday, the most expensive travel day of the week, you can expect to see flight prices from Islip, New York to Knoxville for around $588.
What is the cheapest time of day to depart on your flight to Knoxville?
In the morning is the cheapest time of day to fly from Islip, New York to Knoxville when you can find flight prices for as low as $364. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $527.
When to book flights from Islip, New York to Knoxville
Cheap Islip, New York to Knoxville (ISP to TYS) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Knoxville
Frequently asked questions about flying from Islip, New York to Knoxville
How far is Islip Long Island to Knoxville McGhee Tyson by plane?
A flight from Islip Long Island to Knoxville McGhee Tyson will travel around 666.2 mi. In terms of flight time, this usually takes a little over 3h 55m.
When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
As of October 2026, there is 1 operator available to choose from for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Islip, New York to Knoxville?
Based on momondo bookings for flights between Islip, New York and Knoxville, the leading airline is Southwest, making up 100% of the total bookings.
Best airlines flying from Islip, New York to Knoxville
Compare and see reviews for airlines that fly from Islip, New York to Knoxville with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $256 | Free Cancellation | Rating 7.9 4,222 reviews |
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Islip to Knoxville?
momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Islip to Knoxville. Millions of users trust and use momondo every year so you are in good hands.
Can I find flights from Islip to Knoxville with flexible booking policies on momondo?
All flight searches from Islip to Knoxville on momondo can be filtered to show those which offer flexible booking policies.
How can momondo help me find flights from Islip to Knoxville?
momondo helps you find the best flight between Islip and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.
I’m not ready to book a flight from Islip to Knoxville right now. Can momondo alert me if prices change?
Of course. momondo tracks the price of Islip to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.