What airlines fly to Knoxville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Knoxville from Islip, New York according to our data. American Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 5 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.

How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$203 Cheap Flights from Islip to Knoxville in 2025/26

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Find the cheapest flights from Islip, New York to Knoxville

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

4:40 pm - 8:33 am

ISP

TYS

15h 53m1 stop

3:53 pm - 11:15 am

TYS

ISP

19h 22m2 stops

$247Multiple Airlines

Thu, Jan 1 - Wed, Jan 7

12:20 pm - 10:15 am

ISP

TYS

21h 55m1 stop

6:00 am - 7:39 pm

TYS

ISP

13h 39m1 stop

$310Multiple Airlines

Thu, Jan 1 - Mon, Jan 5

4:30 pm - 9:15 pm

ISP

TYS

4h 45m1 stop

8:15 am - 11:55 am

TYS

ISP

3h 40m1 stop

$337Southwest

Fri, Apr 17 - Wed, Apr 22

4:30 pm - 9:15 pm

ISP

TYS

4h 45m1 stop

12:15 pm - 8:25 pm

TYS

ISP

8h 10m2 stops

$342Southwest

Fri, May 1 - Mon, May 4

6:00 am - 6:10 pm

ISP

TYS

12h 10m2 stops

12:50 pm - 10:10 pm

TYS

ISP

9h 20m2 stops

$347Southwest

Fri, Apr 17 - Wed, Apr 22

12:15 pm - 6:45 pm

ISP

TYS

6h 30m1 stop

7:50 am - 11:40 am

TYS

ISP

3h 50m1 stop

$357Southwest

Fri, Mar 20 - Mon, Mar 23

4:40 pm - 8:18 am

ISP

TYS

15h 38m1 stop

6:00 am - 7:39 pm

TYS

ISP

13h 39m1 stop

$361Multiple Airlines

Fri, Jan 2 - Mon, Jan 5

12:15 pm - 6:45 pm

ISP

TYS

6h 30m1 stop

1:20 pm - 11:55 pm

TYS

ISP

10h 35m2 stops

$362Southwest

Fri, Mar 20 - Mon, Mar 23

12:20 pm - 10:15 am

ISP

TYS

21h 55m1 stop

7:15 am - 8:07 pm

TYS

ISP

12h 52m2 stops

$366Multiple Airlines

Thu, Jan 1 - Mon, Jan 5

6:00 am - 6:45 pm

ISP

TYS

12h 45m2 stops

3:45 pm - 11:55 pm

TYS

ISP

8h 10m2 stops

$373Southwest

Fri, Mar 20 - Mon, Mar 23

Southwest flights from Islip, New York to Knoxville

Our best Southwest deals on Islip, New York to Knoxville flight tickets

Southwest

Apr 17

ISP4:30 pmIslip Long Island

4h 45m

1 stop

TYS9:15 pmKnoxville McGhee Tyson

Apr 22

TYS8:15 amKnoxville McGhee Tyson

3h 40m

1 stop

ISP11:55 amIslip Long Island

$337

Find similar

Southwest

May 1

ISP4:30 pmIslip Long Island

4h 45m

1 stop

TYS9:15 pmKnoxville McGhee Tyson

May 4

TYS12:15 pmKnoxville McGhee Tyson

8h 10m

2 stops

ISP8:25 pmIslip Long Island

$342

Find similar

Southwest

Apr 17

ISP6:00 amIslip Long Island

12h 10m

2 stops

TYS6:10 pmKnoxville McGhee Tyson

Apr 22

TYS12:50 pmKnoxville McGhee Tyson

9h 20m

2 stops

ISP10:10 pmIslip Long Island

$347

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Islip, New York to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Thu 1/1

4:40 pm-8:33 am

1 stop15h 53m

Knoxville McGhee Tyson

Wed 1/7

3:53 pm-11:15 am

2 stops19h 22m

$247

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Thu 1/1

12:20 pm-10:15 am

1 stop21h 55m

Knoxville McGhee Tyson

Mon 1/5

6:00 am-7:39 pm

1 stop13h 39m

$310

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 4/17

4:30 pm-9:15 pm

1 stop4h 45m

Knoxville McGhee Tyson

Wed 4/22

8:15 am-11:55 am

1 stop3h 40m

$337

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 5/1

4:30 pm-9:15 pm

1 stop4h 45m

Knoxville McGhee Tyson

Mon 5/4

12:15 pm-8:25 pm

2 stops8h 10m

$342

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 4/17

6:00 am-6:10 pm

2 stops12h 10m

Knoxville McGhee Tyson

Wed 4/22

12:50 pm-10:10 pm

2 stops9h 20m

$347

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 3/20

12:15 pm-6:45 pm

1 stop6h 30m

Knoxville McGhee Tyson

Mon 3/23

7:50 am-11:40 am

1 stop3h 50m

$357

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 1/2

4:40 pm-8:18 am

1 stop15h 38m

Knoxville McGhee Tyson

Mon 1/5

6:00 am-7:39 pm

1 stop13h 39m

$361

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 3/20

12:15 pm-6:45 pm

1 stop6h 30m

Knoxville McGhee Tyson

Mon 3/23

1:20 pm-11:55 pm

2 stops10h 35m

$362

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Thu 1/1

12:20 pm-10:15 am

1 stop21h 55m

Knoxville McGhee Tyson

Mon 1/5

7:15 am-8:07 pm

2 stops12h 52m

$366

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Fri 3/20

6:00 am-6:45 pm

2 stops12h 45m

Knoxville McGhee Tyson

Mon 3/23

3:45 pm-11:55 pm

2 stops8h 10m

$373

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Islip, New York to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Islip, New York to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $262. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Islip, New York to Knoxville for around $429.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Islip, New York to Knoxville when you can find flight prices for as low as $284. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $357.

When to book flights from Islip, New York to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip, New York to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Islip, New York to Knoxville (ISP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip, New York to Knoxville

Fastest flight time	4h 45m
Direct flights	None

The fastest flight from Islip, New York to Knoxville takes 4h 45m

There are no direct flights from Islip, New York to Knoxville. There are no popular flight routes from Islip, New York to Knoxville.

Search flight deals

How far is Islip Long Island to Knoxville McGhee Tyson by plane?
A flight from Islip Long Island to Knoxville McGhee Tyson will travel around 666.2 mi. In terms of flight time, this usually takes a little over 4h 45m.
When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.
How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

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Morristown

Corbin

Maryville

Crossville

Murphy

Alcoa

Oak Ridge

Newport

Lenoir City

Kodak

Dandridge

Jefferson City

Clinton

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Islip to Knoxville?

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Can I find flights from Islip to Knoxville with flexible booking policies on momondo?

All flight searches from Islip to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Knoxville?

momondo helps you find the best flight between Islip and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

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Of course. momondo tracks the price of Islip to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.