What airlines fly to Knoxville?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Knoxville from Islip according to our data. American Airlines is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 5 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.

How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$203 Cheap Flights from Islip to Knoxville in 2025/26

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7:30 am - 1:01 pmISP-TYS

5h 31m1 stop

2:55 pm - 9:38 amTYS-ISP

18h 43m2 stops

$582Multiple Airlines

Find Deal

Tue, Nov 11 - Thu, Nov 13

9:59 am - 2:34 pmISP-TYS

28h 35m1 stop

12:53 pm - 8:14 pmTYS-ISP

31h 21m2 stops

$652Multiple Airlines

Find Deal

Wed, Nov 26 - Wed, Dec 3

9:59 am - 1:31 pmISP-TYS

27h 32m1 stop

8:15 am - 10:37 amTYS-ISP

26h 22m1 stop

$683Multiple Airlines

Find Deal

Mon, Oct 27 - Fri, Oct 31

12:40 pm - 10:33 amISP-TYS

21h 53m2 stops

8:15 am - 10:37 amTYS-ISP

26h 22m1 stop

$695Multiple Airlines

Find Deal

Mon, Oct 27 - Fri, Oct 31

7:30 am - 1:01 pmISP-TYS

5h 31m1 stop

8:30 am - 4:15 pmTYS-ISP

7h 45m1 stop

$867Multiple Airlines

Find Deal

Tue, Nov 11 - Thu, Nov 13

12:40 pm - 5:08 pmISP-TYS

28h 28m2 stops

7:25 pm - 7:45 pmTYS-ISP

24h 20m2 stops

$946Multiple Airlines

Find Deal

Wed, Nov 26 - Wed, Dec 3

12:40 pm - 2:43 pmISP-TYS

26h 03m2 stops

10:50 am - 11:04 amTYS-ISP

24h 14m2 stops

$983Multiple Airlines

Find Deal

Tue, Nov 11 - Thu, Nov 13

7:30 am - 10:55 pmISP-TYS

15h 25m3 stops

6:45 am - 4:15 pmTYS-ISP

9h 30m2 stops

$1,069Multiple Airlines

Find Deal

Tue, Nov 11 - Thu, Nov 13

Fly from

Fly to

Route

Depart

Return

Price

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Tue 11/11

7:30 am-1:01 pm

1 stop5h 31m

Knoxville McGhee Tyson

Thu 11/13

2:55 pm-9:38 am

2 stops18h 43m

$582

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Wed 11/26

9:59 am-2:34 pm

1 stop28h 35m

Knoxville McGhee Tyson

Wed 12/3

12:53 pm-8:14 pm

2 stops31h 21m

$652

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Mon 10/27

9:59 am-1:31 pm

1 stop27h 32m

Knoxville McGhee Tyson

Fri 10/31

8:15 am-10:37 am

1 stop26h 22m

$683

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Mon 10/27

12:40 pm-10:33 am

2 stops21h 53m

Knoxville McGhee Tyson

Fri 10/31

8:15 am-10:37 am

1 stop26h 22m

$695

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Tue 11/11

7:30 am-1:01 pm

1 stop5h 31m

Knoxville McGhee Tyson

Thu 11/13

8:30 am-4:15 pm

1 stop7h 45m

$867

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Wed 11/26

12:40 pm-5:08 pm

2 stops28h 28m

Knoxville McGhee Tyson

Wed 12/3

7:25 pm-7:45 pm

2 stops24h 20m

$946

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Tue 11/11

12:40 pm-2:43 pm

2 stops26h 03m

Knoxville McGhee Tyson

Thu 11/13

10:50 am-11:04 am

2 stops24h 14m

$983

IslipKnoxville

ISP - TYS

ISPTYS

Islip Long Island

Tue 11/11

7:30 am-10:55 pm

3 stops15h 25m

Knoxville McGhee Tyson

Thu 11/13

6:45 am-4:15 pm

2 stops9h 30m

$1,069

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

How to get the cheapest flight ticket from Islip to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Islip to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $256. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Islip to Knoxville for around $421.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Islip to Knoxville when you can find flight prices for as low as $276. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $359.

When to book flights from Islip to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Islip to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Islip to Knoxville (ISP to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Islip to Knoxville

Direct flights	None

There are no direct flights from Islip to Knoxville. There are no popular flight routes from Islip to Knoxville.

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How far is Islip Long Island to Knoxville McGhee Tyson by plane?
A flight from Islip Long Island to Knoxville McGhee Tyson will travel around 666.2 mi. In terms of flight time, this usually takes a little over 5h 31m.
When did momondo last update prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Islip Long Island Airport to Knoxville McGhee Tyson Airport were last updated today.
How old do you have to be to fly from Islip Long Island Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Islip Long Island Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

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Why use momondo?

Why should I use momondo to find a flight deal from Islip to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Islip to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Islip to Knoxville with flexible booking policies on momondo?

All flight searches from Islip to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Islip to Knoxville?

momondo helps you find the best flight between Islip and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Islip to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Islip to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.