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Cheap flights from Iowa to Florence from $543

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Florence departing on 8/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Iowa to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:09 am - 2:56 pm
MLI
-
FLO
5h 47m
1 stop
American Airlines Logo
3:22 pm - 9:13 pm
FLO
-
MLI
6h 51m
1 stop
$543American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
4:05 pm - 10:59 pm
MLI
-
FLO
5h 54m
1 stop
American Airlines Logo
3:22 pm - 12:08 am
FLO
-
MLI
9h 46m
2 stops
$548American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
11:43 am - 10:59 pm
MLI
-
FLO
10h 16m
2 stops
American Airlines Logo
3:22 pm - 12:08 am
FLO
-
MLI
9h 46m
2 stops
$553American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
4:21 pm - 11:58 pm
MLI
-
FLO
6h 37m
1 stop
American Airlines Logo
3:22 pm - 9:13 pm
FLO
-
MLI
6h 51m
1 stop
$598American Airlines
Sun, Aug 9 - Sat, Aug 15
American Airlines Logo
8:09 am - 2:56 pm
MLI
-
FLO
5h 47m
1 stop
American Airlines Logo
5:05 am - 11:13 am
FLO
-
MLI
7h 08m
2 stops
$603American Airlines
Sat, Aug 8 - Sun, Aug 16
American Airlines Logo
11:43 am - 10:59 pm
MLI
-
FLO
10h 16m
2 stops
American Airlines Logo
5:05 am - 11:13 am
FLO
-
MLI
7h 08m
2 stops
$608American Airlines
Sat, Aug 8 - Sun, Aug 16
American Airlines Logo
7:00 am - 2:12 pm
MLI
-
FLO
6h 12m
1 stop
American Airlines Logo
5:05 am - 11:13 am
FLO
-
MLI
7h 08m
2 stops
$610American Airlines
Sun, Aug 9 - Sun, Aug 16
American Airlines Logo
6:44 am - 2:12 pm
CID
-
FLO
6h 28m
1 stop
American Airlines Logo
3:22 pm - 9:42 pm
FLO
-
CID
7h 20m
1 stop
$629American Airlines
Sun, Aug 9 - Sat, Aug 15
American Airlines Logo
1:31 pm - 10:59 pm
CID
-
FLO
8h 28m
2 stops
American Airlines Logo
3:22 pm - 9:42 pm
FLO
-
CID
7h 20m
1 stop
$657American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
6:44 am - 2:12 pm
CID
-
FLO
6h 28m
1 stop
American Airlines Logo
6:22 am - 1:13 pm
FLO
-
CID
7h 51m
2 stops
$677American Airlines
Sun, Aug 9 - Sat, Aug 15

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American Airlines flights from Iowa to Florence, South Carolina

Our best American Airlines deals on Iowa to Florence, South Carolina flight tickets
American Airlines
Aug 8
MLI8:09 amMoline Quad-City
5h 47m
1 stop
FLO2:56 pmFlorence
Aug 15
FLO3:22 pmFlorence
6h 51m
1 stop
MLI9:13 pmMoline Quad-City
$543
American Airlines
Aug 8
MLI4:05 pmMoline Quad-City
5h 54m
1 stop
FLO10:59 pmFlorence
Aug 15
FLO3:22 pmFlorence
9h 46m
2 stops
MLI12:08 amMoline Quad-City
$548
American Airlines
Aug 8
MLI11:43 amMoline Quad-City
10h 16m
2 stops
FLO10:59 pmFlorence
Aug 15
FLO3:22 pmFlorence
9h 46m
2 stops
MLI12:08 amMoline Quad-City
$553

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 26, 2026.
Use the filters below to find and compare flights from Iowa to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

8:09 am-2:56 pm

1 stop5h 47m

Florence

Sat 8/15

3:22 pm-9:13 pm

1 stop6h 51m

$543

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

4:05 pm-10:59 pm

1 stop5h 54m

Florence

Sat 8/15

3:22 pm-12:08 am

2 stops9h 46m

$548

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

11:43 am-10:59 pm

2 stops10h 16m

Florence

Sat 8/15

3:22 pm-12:08 am

2 stops9h 46m

$553

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sun 8/9

4:21 pm-11:58 pm

1 stop6h 37m

Florence

Sat 8/15

3:22 pm-9:13 pm

1 stop6h 51m

$598

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

8:09 am-2:56 pm

1 stop5h 47m

Florence

Sun 8/16

5:05 am-11:13 am

2 stops7h 08m

$603

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sat 8/8

11:43 am-10:59 pm

2 stops10h 16m

Florence

Sun 8/16

5:05 am-11:13 am

2 stops7h 08m

$608

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Sun 8/9

7:00 am-2:12 pm

1 stop6h 12m

Florence

Sun 8/16

5:05 am-11:13 am

2 stops7h 08m

$610

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sun 8/9

6:44 am-2:12 pm

1 stop6h 28m

Florence

Sat 8/15

3:22 pm-9:42 pm

1 stop7h 20m

$629

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sat 8/8

1:31 pm-10:59 pm

2 stops8h 28m

Florence

Sat 8/15

3:22 pm-9:42 pm

1 stop7h 20m

$657

Cedar RapidsFlorence

CID - FLO

CIDFLO

Cedar Rapids

Sun 8/9

6:44 am-2:12 pm

1 stop6h 28m

Florence

Sat 8/15

6:22 am-1:13 pm

2 stops7h 51m

$677

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Iowa to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Florence, South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 72% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 4 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Iowa to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Florence, South Carolina

Fastest flight time

5h 47m

Direct flights

None
The fastest flight from Iowa to Florence, South Carolina takes 5h 47m
There are no direct flights from Iowa to Florence, South Carolina. There are no popular flight routes from Iowa to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Iowa to Florence, South Carolina

  • When did momondo last update prices for flights from Iowa to Florence Airport?

    Prices for flights from Iowa to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Iowa to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Iowa to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Iowa to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Iowa to Florence with flexible booking policies on momondo?

All flight searches from Iowa to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Florence?

Once all potential Iowa to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Iowa to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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