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Cheap flights from Indianapolis to South Carolina from $66

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Indianapolis to South Carolina

Cheap round-trip flights

Spirit Airlines Logo
5:15 am - 1:35 pmIND-CLT
8h 20m1 stop
Spirit Airlines Logo
5:38 pm - 7:21 pmCLT-IND
1h 43mnonstop
$142Spirit Airlines
Find Deal
mar., oct. 21 - jue., oct. 23
Frontier Logo
10:14 pm - 8:00 amIND-CLT
9h 46m1 stop
Frontier Logo
11:54 am - 9:32 pmCLT-IND
9h 38m1 stop
$143Frontier
Find Deal
sáb., oct. 11 - lun., oct. 13
American Airlines Logo
4:21 pm - 6:03 pmIND-CLT
1h 42mnonstop
American Airlines Logo
8:05 pm - 9:45 pmCLT-IND
1h 40mnonstop
$161American Airlines
Find Deal
mar., oct. 21 - mar., oct. 28
American Airlines Logo
3:43 pm - 5:26 pmIND-CLT
1h 43mnonstop
American Airlines Logo
8:55 pm - 10:39 pmCLT-IND
1h 44mnonstop
$181American Airlines
Find Deal
sáb., oct. 25 - lun., oct. 27
Delta Logo
7:00 am - 10:16 amIND-CAE
3h 16m1 stop
Delta Logo
4:03 pm - 9:45 pmCAE-IND
5h 42m1 stop
$229Delta
Find Deal
mié., oct. 15 - mar., oct. 21
Delta Logo
6:30 am - 10:32 amIND-SAV
4h 02m1 stop
Delta Logo
7:00 am - 12:16 pmSAV-IND
5h 16m1 stop
$237Delta
Find Deal
mié., nov. 5 - mié., nov. 12
Southwest Logo
5:35 am - 10:00 amIND-GSP
4h 25m1 stop
Southwest Logo
3:05 pm - 10:20 pmGSP-IND
7h 15m1 stop
$257Southwest
Find Deal
mar., nov. 18 - jue., nov. 20
Southwest Logo
5:35 am - 4:05 pmIND-GSP
10h 30m2 stops
Southwest Logo
3:05 pm - 10:20 pmGSP-IND
7h 15m1 stop
$262Southwest
Find Deal
mar., nov. 18 - jue., nov. 20
Allegiant Air Logo
1:36 pm - 11:06 pmIND-SAV
9h 30m1 stop
Allegiant Air Logo
7:14 am - 10:28 pmSAV-IND
15h 14m1 stop
$301Allegiant Air
Find Deal
jue., nov. 20 - mar., nov. 25
Allegiant Air Logo
12:07 pm - 2:48 pmIND-GSP
26h 41m1 stop
Allegiant Air Logo
4:18 pm - 8:22 pmGSP-IND
28h 04m1 stop
$467Allegiant Air
Find Deal
vie., oct. 10 - mar., oct. 14

Frontier flights from Indianapolis to South Carolina

Our best Frontier deals on Indianapolis to South Carolina flight tickets
Frontier
Oct 11
IND10:14 pmIndianapolis
9h 46m
1 stop
CLT8:00 amCharlotte Douglas
Oct 13
CLT11:54 amCharlotte Douglas
9h 38m
1 stop
IND9:32 pmIndianapolis
$143
Find similar
Frontier
Oct 3
IND10:47 amIndianapolis
8h 18m
1 stop
CLT7:05 pmCharlotte Douglas
Oct 11
CLT4:00 pmCharlotte Douglas
5h 19m
1 stop
IND9:19 pmIndianapolis
$144
Find similar
Frontier
Oct 18
IND10:14 pmIndianapolis
9h 46m
1 stop
CLT8:00 amCharlotte Douglas
Oct 20
CLT2:14 pmCharlotte Douglas
6h 57m
1 stop
IND9:11 pmIndianapolis
$149
Find similar

Spirit Airlines flights from Indianapolis to South Carolina

Our best Spirit Airlines deals on Indianapolis to South Carolina flight tickets
Spirit Airlines
Oct 21
IND5:15 amIndianapolis
8h 20m
1 stop
CLT1:35 pmCharlotte Douglas
Oct 23
CLT5:38 pmCharlotte Douglas
1h 43m
IND7:21 pmIndianapolis
$142
Find similar
Spirit Airlines
Oct 26
IND7:06 pmIndianapolis
1h 45m
CLT8:51 pmCharlotte Douglas
Oct 28
CLT8:52 amCharlotte Douglas
8h 15m
1 stop
IND5:07 pmIndianapolis
$148
Find similar
Spirit Airlines
Nov 2
IND7:06 pmIndianapolis
1h 45m
CLT8:51 pmCharlotte Douglas
Nov 5
CLT7:31 pmCharlotte Douglas
5h 01m
1 stop
IND12:32 amIndianapolis
$150
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 24, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

mar. 10/21

5:15 am-1:35 pm

1 stop8h 20m

Charlotte Douglas

jue. 10/23

5:38 pm-7:21 pm

Nonstop1h 43m

$142

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

sáb. 10/11

10:14 pm-8:00 am

1 stop9h 46m

Charlotte Douglas

lun. 10/13

11:54 am-9:32 pm

1 stop9h 38m

$143

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

mar. 10/21

4:21 pm-6:03 pm

Nonstop1h 42m

Charlotte Douglas

mar. 10/28

8:05 pm-9:45 pm

Nonstop1h 40m

$161

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

sáb. 10/25

3:43 pm-5:26 pm

Nonstop1h 43m

Charlotte Douglas

lun. 10/27

8:55 pm-10:39 pm

Nonstop1h 44m

$181

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

mié. 10/15

7:00 am-10:16 am

1 stop3h 16m

Columbia Metropolitan

mar. 10/21

4:03 pm-9:45 pm

1 stop5h 42m

$229

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

mié. 11/5

6:30 am-10:32 am

1 stop4h 02m

Savannah/Hilton Head

mié. 11/12

7:00 am-12:16 pm

1 stop5h 16m

$237

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

mar. 11/18

5:35 am-10:00 am

1 stop4h 25m

Greenville

jue. 11/20

3:05 pm-10:20 pm

1 stop7h 15m

$257

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

mar. 11/18

5:35 am-4:05 pm

2 stops10h 30m

Greenville

jue. 11/20

3:05 pm-10:20 pm

1 stop7h 15m

$262

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

jue. 11/20

1:36 pm-11:06 pm

1 stop9h 30m

Savannah/Hilton Head

mar. 11/25

7:14 am-10:28 pm

1 stop15h 14m

$301

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

vie. 10/10

12:07 pm-2:48 pm

1 stop26h 41m

Greenville

mar. 10/14

4:18 pm-8:22 pm

1 stop28h 04m

$467

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Indianapolis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indianapolis is in June. Flight prices, which tend to average around $164, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of June, then book flights to South Carolina from Indianapolis during July instead. Flights to South Carolina in July, while not as cheap as those in June, still average around $224.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $45. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $372.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Indianapolis to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $141. Try not to purchase tickets in the evening because they tend to be around $326. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Indianapolis to South Carolina flight route?

Fly from Indianapolis to Charleston for the best Indianapolis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $316 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indianapolis for as low as $152 on momondo.

What cabin class options are available on Indianapolis to South Carolina flights?

There is only 1 cabin class available to choose from on Indianapolis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indianapolis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indianapolis to South Carolina.

Cheap Indianapolis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to South Carolina

Fastest flight time

1h 40m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Indianapolis to South Carolina takes 1h 40m
Direct flights go from Indianapolis to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Indianapolis Airport to South Carolina?

    Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Indianapolis Airport to South Carolina?

  • How old do you have to be to fly from Indianapolis Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Indianapolis to South Carolina?

Best airlines flying from Indianapolis to South Carolina

Compare and see reviews for airlines that fly from Indianapolis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
Spirit AirlinesPriceFrom $134Free CancellationRating
6.3
8,042 reviews
Search Spirit Airlines flights
DeltaPriceFrom $196Free CancellationRating
7.9
7,973 reviews
Search Delta flights
American AirlinesPriceFrom $211Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $225Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
SouthwestPriceFrom $247Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Indianapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Indianapolis to South Carolina?

momondo helps you find the best flight between Indianapolis and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Indianapolis to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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vie. 10/24
vie. 10/31
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