What airlines fly to South Carolina?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Indianapolis according to our data. Allegiant Air is the first choice among our users, with 44% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Indianapolis to South Carolina?

Southwest, Delta, and Allegiant Air are the most popular carriers operating from Indianapolis to South Carolina

When did momondo last update prices for flights from Indianapolis Airport to South Carolina?

Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Indianapolis Airport to South Carolina?

The number of operators available for flights from Indianapolis Airport to South Carolina is 5 as of October 2026.

How old do you have to be to fly from Indianapolis Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$101 Cheap Flights from Indianapolis to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Indianapolis to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:09 am - 2:52 pmIND Indianapolis-CHS Charleston

3h 43m1 stop Charlotte Douglas

7:13 am - 12:08 pmCHS Charleston-IND Indianapolis

4h 55m1 stop Chicago O'Hare Intl

$221American Airlines

Tue, Oct 27 - Tue, Nov 10

7:41 am - 1:36 pmIND Indianapolis-CHS Charleston

5h 55m1 stop Washington, D.C. Reagan-National

12:17 pm - 7:18 pmCHS Charleston-IND Indianapolis

7h 01m1 stop Chicago O'Hare Intl

$221American Airlines

Wed, Nov 18 - Tue, Dec 1

11:35 am - 4:29 pmIND Indianapolis-CHS Charleston

4h 54m1 stop Atlanta Hartsfield-Jackson

5:10 am - 9:08 amCHS Charleston-IND Indianapolis

3h 58m1 stop Atlanta Hartsfield-Jackson

$239Delta

Thu, Nov 26 - Tue, Dec 1

11:48 am - 4:29 pmIND Indianapolis-CHS Charleston

4h 41m1 stop Atlanta Hartsfield-Jackson

5:20 am - 9:08 amCHS Charleston-IND Indianapolis

3h 48m1 stop Atlanta Hartsfield-Jackson

$239Delta

Tue, Nov 17 - Thu, Nov 19

5:10 am - 2:06 pmIND Indianapolis-CHS Charleston

8h 56m2 stops Chicago O'Hare Intl Newark

2:42 pm - 7:29 pmCHS Charleston-IND Indianapolis

4h 47m1 stop Washington, D.C. Dulles Intl

$244United Airlines

Mon, Jan 11 - Sat, Jan 16

7:05 am - 5:25 pmIND Indianapolis-CHS Charleston

10h 20m2 stops Dallas Love Field Nashville Intl

7:30 am - 12:05 pmCHS Charleston-IND Indianapolis

4h 35m1 stop Baltimore/Washington

$245Southwest

Tue, Nov 17 - Thu, Nov 19

7:19 pm - 9:32 amIND Indianapolis-GSP Greenville

38h 13m2 stops Atlanta Hartsfield-Jackson Tampa

2:42 pm - 12:25 pmGSP Greenville-IND Indianapolis

21h 43m1 stop Fort Lauderdale

$248Multiple Airlines

Tue, Dec 8 - Mon, Dec 14

5:50 am - 2:50 pmIND Indianapolis-CHS Charleston

9h 00m2 stops Baltimore/Washington Nashville Intl

3:35 pm - 10:55 pmCHS Charleston-IND Indianapolis

7h 20m2 stops Nashville Intl Baltimore/Washington

$250Southwest

Mon, Jan 11 - Sat, Jan 16

11:25 am - 8:48 amIND Indianapolis-CHS Charleston

21h 23m1 stop Orlando

3:00 pm - 6:57 pmCHS Charleston-IND Indianapolis

27h 57m2 stops Orlando Atlanta Hartsfield-Jackson

$269Multiple Airlines

Thu, Oct 29 - Tue, Nov 3

5:45 am - 10:06 amIND Indianapolis-CHS Charleston

4h 21m1 stop Washington, D.C. Dulles Intl

7:00 pm - 11:47 pmCHS Charleston-IND Indianapolis

4h 47m1 stop Chicago O'Hare Intl

$309United Airlines

Thu, Nov 12 - Thu, Nov 12

Cheap last minute flights

Enter your travel dates to find the best prices.

11:37 am - 4:57 pmIND Indianapolis-CAE Columbia Metropolitan

5h 20m1 stop Chicago O'Hare Intl

6:15 am - 10:56 amCAE Columbia Metropolitan-IND Indianapolis

4h 41m1 stop Chicago O'Hare Intl

$389United Airlines

Thu, Oct 8 - Sun, Oct 11

6:00 am - 12:19 pmIND Indianapolis-CAE Columbia Metropolitan

6h 19m1 stop Charlotte Douglas

8:30 pm - 12:37 amCAE Columbia Metropolitan-IND Indianapolis

4h 07m1 stop Charlotte Douglas

$399American Airlines

Thu, Oct 8 - Sun, Oct 11

6:00 am - 9:30 amIND Indianapolis-CAE Columbia Metropolitan

3h 30m1 stop Atlanta Hartsfield-Jackson

7:19 pm - 12:25 amCAE Columbia Metropolitan-IND Indianapolis

5h 06m1 stop Atlanta Hartsfield-Jackson

$399Delta

Thu, Oct 8 - Sun, Oct 11

6:00 am - 12:19 pmIND Indianapolis-CAE Columbia Metropolitan

6h 19m1 stop Charlotte Douglas

8:30 pm - 12:37 amCAE Columbia Metropolitan-IND Indianapolis

4h 07m1 stop Charlotte Douglas

$409American Airlines

Thu, Oct 8 - Sun, Oct 11

10:00 am - 8:09 amIND Indianapolis-GSP Greenville

22h 09m1 stop Orlando Sanford Intl

3:04 pm - 8:18 amGSP Greenville-IND Indianapolis

17h 14m1 stop Sarasota Bradenton Intl

$454Allegiant Air

Wed, Oct 7 - Thu, Oct 8

6:41 am - 3:30 pmIND Indianapolis-HHH Hilton Head Island

8h 49m2 stops Detroit Metropolitan Wayne County Atlanta Hartsfield-Jackson

4:13 pm - 10:12 pmHHH Hilton Head Island-IND Indianapolis

5h 59m1 stop New York LaGuardia

$460Delta

Wed, Oct 7 - Wed, Oct 14

7:05 am - 2:26 pmIND Indianapolis-CAE Columbia Metropolitan

7h 21m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

6:15 am - 12:42 pmCAE Columbia Metropolitan-IND Indianapolis

6h 27m1 stop Chicago O'Hare Intl

$504United Airlines

Thu, Oct 8 - Sun, Oct 11

10:33 am - 1:40 pmIND Indianapolis-GSP Greenville

27h 07m2 stops Atlanta Hartsfield-Jackson Orlando

3:34 pm - 10:20 amGSP Greenville-IND Indianapolis

18h 46m1 stop Sarasota Bradenton Intl

$506Multiple Airlines

Fri, Oct 9 - Sun, Oct 11

9:06 pm - 8:38 amIND Indianapolis-CHS Charleston

11h 32m1 stop Orlando

3:00 pm - 10:26 amCHS Charleston-IND Indianapolis

19h 26m1 stop Orlando

$527Multiple Airlines

Sat, Oct 10 - Tue, Oct 13

7:05 am - 5:55 pmIND Indianapolis-CHS Charleston

10h 50m1 stop Dallas Love Field

6:15 am - 1:35 pmCHS Charleston-IND Indianapolis

7h 20m1 stop Nashville Intl

$532Southwest

Sat, Oct 10 - Sat, Oct 17

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Delta flights from Indianapolis to South Carolina

Our best Delta deals on Indianapolis to South Carolina flight tickets

Delta

Nov 17

IND11:48 amIndianapolis

4h 41m

1 stop

CHS4:29 pmCharleston

Nov 19

CHS5:20 amCharleston

3h 48m

1 stop

IND9:08 amIndianapolis

$239

Delta

Nov 11

IND6:00 amIndianapolis

4h 07m

1 stop

MYR10:07 amMyrtle Beach Intl

Nov 14

MYR6:00 amMyrtle Beach Intl

6h 56m

1 stop

IND12:56 pmIndianapolis

$257

Delta

Oct 26

IND2:19 pmIndianapolis

6h 39m

1 stop

CHS8:58 pmCharleston

Oct 31

CHS6:00 amCharleston

4h 25m

1 stop

IND10:25 amIndianapolis

$269

United Airlines flights from Indianapolis to South Carolina

Our best United Airlines deals on Indianapolis to South Carolina flight tickets

United Airlines

Jan 11

IND5:10 amIndianapolis

8h 56m

2 stops

CHS2:06 pmCharleston

Jan 16

CHS2:42 pmCharleston

4h 47m

1 stop

IND7:29 pmIndianapolis

$244

United Airlines

Nov 12

IND5:45 amIndianapolis

4h 21m

1 stop

CHS10:06 amCharleston

Nov 12

CHS7:00 pmCharleston

4h 47m

1 stop

IND11:47 pmIndianapolis

$309

United Airlines

Oct 29

IND5:45 amIndianapolis

4h 21m

1 stop

CHS10:06 amCharleston

Nov 2

CHS10:23 amCharleston

7h 18m

2 stops

IND5:41 pmIndianapolis

$314

momondo Fare Finder

Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Tue 10/27

11:09 am-2:52 pm

1 stop3h 43m

Charleston

Tue 11/10

7:13 am-12:08 pm

1 stop4h 55m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Wed 11/18

7:41 am-1:36 pm

1 stop5h 55m

Charleston

Tue 12/1

12:17 pm-7:18 pm

1 stop7h 01m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Thu 11/26

11:35 am-4:29 pm

1 stop4h 54m

Charleston

Tue 12/1

5:10 am-9:08 am

1 stop3h 58m

$239

Quickest round-trip

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Tue 11/17

11:48 am-4:29 pm

1 stop4h 41m

Charleston

Thu 11/19

5:20 am-9:08 am

1 stop3h 48m

$239

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 1/11

5:10 am-2:06 pm

2 stops8h 56m

Charleston

Sat 1/16

2:42 pm-7:29 pm

1 stop4h 47m

$244

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Tue 11/17

7:05 am-5:25 pm

2 stops10h 20m

Charleston

Thu 11/19

7:30 am-12:05 pm

1 stop4h 35m

$245

IndianapolisGreenville

IND Indianapolis - GSP Greenville

INDGSP

Indianapolis

Tue 12/8

7:19 pm-9:32 am

2 stops38h 13m

Greenville

Mon 12/14

2:42 pm-12:25 pm

1 stop21h 43m

$248

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Mon 1/11

5:50 am-2:50 pm

2 stops9h 00m

Charleston

Sat 1/16

3:35 pm-10:55 pm

2 stops7h 20m

$250

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Thu 10/29

11:25 am-8:48 am

1 stop21h 23m

Charleston

Tue 11/3

3:00 pm-6:57 pm

2 stops27h 57m

$269

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

Thu 11/12

5:45 am-10:06 am

1 stop4h 21m

Charleston

Thu 11/12

7:00 pm-11:47 pm

1 stop4h 47m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Indianapolis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indianapolis is in July. Flight prices, which tend to average around $184, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to South Carolina from Indianapolis during June instead. Flights to South Carolina in June, while not as cheap as those in July, still average around $288.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $92. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $138.

What is the cheapest Indianapolis to South Carolina flight route?

Fly from Indianapolis to Myrtle Beach Intl for the best Indianapolis - South Carolina flight prices

How far in advance should I book a flight from Indianapolis to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $340 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indianapolis for as low as $231 on momondo.

What cabin class options are available on Indianapolis to South Carolina flights?

There is only 1 cabin class available to choose from on Indianapolis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indianapolis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indianapolis to South Carolina.

Cheap Indianapolis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to South Carolina

Best Price Found	$101
Fastest flight time	1h 45m
Direct flights	None

The best one-way flight to South Carolina from Indianapolis in the past 72 hours is $101. The best round-trip flight deal from Indianapolis to South Carolina found on momondo in the last 72 hours is $221.

The fastest flight from Indianapolis to South Carolina takes 1h 45m

There are no direct flights from Indianapolis to South Carolina. There are no popular flight routes from Indianapolis to South Carolina.

Search flight deals

Frequently asked questions about flying from Indianapolis to South Carolina

When did momondo last update prices for flights from Indianapolis Airport to South Carolina?
Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Indianapolis Airport to South Carolina?
The number of operators available for flights from Indianapolis Airport to South Carolina is 5 as of October 2026.
How old do you have to be to fly from Indianapolis Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Indianapolis to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Indianapolis to South Carolina is Airbus A320-100/200, representing 81.82% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 4.55%, Embraer 175 (Enhanced Winglets) at 4.55%, and Embraer 175 at 4.55%.

Best airlines flying from Indianapolis to South Carolina

Compare and see reviews for airlines that fly from Indianapolis to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $74	Free Cancellation	Rating 7.3 678 reviews	Search Allegiant Air flights
Delta	PriceFrom $183	Free Cancellation	Rating 7.8 8,634 reviews	Search Delta flights
American Airlines	PriceFrom $230	Free Cancellation	Rating 7.0 12,127 reviews	Search American Airlines flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 10,288 reviews	Search United Airlines flights
Southwest	PriceFrom $278	Free Cancellation	Rating 7.9 4,214 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Indianapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Indianapolis to South Carolina?

momondo helps you find the best flight between Indianapolis and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Indianapolis to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.