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Cheap flights from Indianapolis to South Carolina from $53

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 9/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Indianapolis to South Carolina

Cheap round-trip flights

Spirit Airlines Logo
7:13 pm - 8:57 pmIND-CLT
1h 44mnonstop
Spirit Airlines Logo
5:05 pm - 6:48 pmCLT-IND
1h 43mnonstop
$99Spirit Airlines
Find Deal
Thu, Sep 11 - Sun, Sep 14
Spirit Airlines Logo
5:00 am - 2:29 pmIND-CLT
9h 29m1 stop
Spirit Airlines Logo
5:05 pm - 6:48 pmCLT-IND
1h 43mnonstop
$112Spirit Airlines
Find Deal
Thu, Sep 4 - Thu, Sep 4
American Airlines Logo
6:56 pm - 8:40 pmIND-CLT
1h 44mnonstop
American Airlines Logo
1:52 pm - 3:29 pmCLT-IND
1h 37mnonstop
$139American Airlines
Find Deal
Sat, Oct 11 - Wed, Oct 15
American Airlines Logo
6:11 am - 7:51 amIND-CLT
1h 40mnonstop
American Airlines Logo
10:35 am - 12:23 pmCLT-IND
1h 48mnonstop
$169American Airlines
Find Deal
Thu, Sep 4 - Tue, Sep 9
Delta Logo
4:58 pm - 8:21 pmIND-CLT
3h 23m1 stop
Delta Logo
6:45 am - 10:33 amCLT-IND
3h 48m1 stop
$177Delta
Find Deal
Sat, Oct 11 - Wed, Oct 15
Southwest Logo
12:55 pm - 9:30 pmIND-CLT
8h 35m2 stops
Southwest Logo
6:00 am - 12:05 pmCLT-IND
6h 05m1 stop
$179Southwest
Find Deal
Wed, Oct 22 - Tue, Oct 28
Southwest Logo
1:50 pm - 9:40 pmIND-CLT
7h 50m2 stops
Southwest Logo
6:35 pm - 10:25 pmCLT-IND
3h 50m1 stop
$194Southwest
Find Deal
Thu, Sep 4 - Tue, Sep 9
United Airlines Logo
6:00 am - 2:15 pmIND-CAE
8h 15m2 stops
United Airlines Logo
11:04 am - 4:32 pmCAE-IND
5h 28m1 stop
$196United Airlines
Find Deal
Sun, Aug 31 - Sat, Sep 6
Delta Logo
1:55 pm - 8:29 pmIND-GSP
6h 34m1 stop
Delta Logo
2:15 pm - 7:03 pmGSP-IND
4h 48m1 stop
$197Delta
Find Deal
Fri, Aug 22 - Tue, Aug 26
United Airlines Logo
5:45 am - 9:49 amIND-GSP
4h 04m1 stop
United Airlines Logo
10:24 am - 5:55 pmGSP-IND
7h 31m2 stops
$215United Airlines
Find Deal
Fri, Aug 22 - Tue, Aug 26

Spirit Airlines flights from Indianapolis to South Carolina

Our best Spirit Airlines deals on Indianapolis to South Carolina flight tickets
Spirit Airlines
Sep 11
IND7:13 pmIndianapolis
1h 44m
CLT8:57 pmCharlotte Douglas
Sep 14
CLT5:05 pmCharlotte Douglas
1h 43m
IND6:48 pmIndianapolis
$99
Find similar
Spirit Airlines
Sep 4
IND5:00 amIndianapolis
9h 29m
1 stop
CLT2:29 pmCharlotte Douglas
Sep 4
CLT5:05 pmCharlotte Douglas
1h 43m
IND6:48 pmIndianapolis
$112
Find similar
Spirit Airlines
Sep 4
IND7:13 pmIndianapolis
1h 44m
CLT8:57 pmCharlotte Douglas
Sep 9
CLT10:46 amCharlotte Douglas
9h 01m
1 stop
IND7:47 pmIndianapolis
$113
Find similar

American Airlines flights from Indianapolis to South Carolina

Our best American Airlines deals on Indianapolis to South Carolina flight tickets
American Airlines
Oct 11
IND6:56 pmIndianapolis
1h 44m
CLT8:40 pmCharlotte Douglas
Oct 15
CLT1:52 pmCharlotte Douglas
1h 37m
IND3:29 pmIndianapolis
$139
Find similar
American Airlines
Sep 4
IND6:11 amIndianapolis
1h 40m
CLT7:51 amCharlotte Douglas
Sep 9
CLT10:35 amCharlotte Douglas
1h 48m
IND12:23 pmIndianapolis
$169
Find similar
American Airlines
Aug 31
IND11:00 amIndianapolis
6h 35m
1 stop
CAE5:35 pmColumbia Metropolitan
Sep 6
CAE3:40 pmColumbia Metropolitan
8h 34m
1 stop
IND12:14 amIndianapolis
$191
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 9/11

7:13 pm-8:57 pm

Nonstop1h 44m

Charlotte Douglas

Sun 9/14

5:05 pm-6:48 pm

Nonstop1h 43m

$99

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 9/4

5:00 am-2:29 pm

1 stop9h 29m

Charlotte Douglas

Thu 9/4

5:05 pm-6:48 pm

Nonstop1h 43m

$112

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sat 10/11

6:56 pm-8:40 pm

Nonstop1h 44m

Charlotte Douglas

Wed 10/15

1:52 pm-3:29 pm

Nonstop1h 37m

$139

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 9/4

6:11 am-7:51 am

Nonstop1h 40m

Charlotte Douglas

Tue 9/9

10:35 am-12:23 pm

Nonstop1h 48m

$169

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sat 10/11

4:58 pm-8:21 pm

1 stop3h 23m

Charlotte Douglas

Wed 10/15

6:45 am-10:33 am

1 stop3h 48m

$177

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Wed 10/22

12:55 pm-9:30 pm

2 stops8h 35m

Charlotte Douglas

Tue 10/28

6:00 am-12:05 pm

1 stop6h 05m

$179

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Thu 9/4

1:50 pm-9:40 pm

2 stops7h 50m

Charlotte Douglas

Tue 9/9

6:35 pm-10:25 pm

1 stop3h 50m

$194

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

Sun 8/31

6:00 am-2:15 pm

2 stops8h 15m

Columbia Metropolitan

Sat 9/6

11:04 am-4:32 pm

1 stop5h 28m

$196

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Fri 8/22

1:55 pm-8:29 pm

1 stop6h 34m

Greenville

Tue 8/26

2:15 pm-7:03 pm

1 stop4h 48m

$197

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Fri 8/22

5:45 am-9:49 am

1 stop4h 04m

Greenville

Tue 8/26

10:24 am-5:55 pm

2 stops7h 31m

$215

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Indianapolis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indianapolis is in June. Flight prices, which tend to average around $165, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of June, then book flights to South Carolina from Indianapolis during July instead. Flights to South Carolina in July, while not as cheap as those in June, still average around $199.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $45. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $372.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Indianapolis to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $138. Try not to purchase tickets in the evening because they tend to be around $326. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Indianapolis to South Carolina flight route?

Fly from Indianapolis to Myrtle Beach Intl for the best Indianapolis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $317 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indianapolis for as low as $201 on momondo.

What cabin class options are available on Indianapolis to South Carolina flights?

There are 1 cabin classes available to choose from on Indianapolis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indianapolis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indianapolis to South Carolina.

Cheap Indianapolis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to South Carolina

Best Price Found

$53

Fastest flight time

1h 40m

Direct flights

Every day

Airports in South Carolina

8 airports
The best one-way flight to South Carolina from Indianapolis in the past 72 hours is $53. The best round-trip flight deal from Indianapolis to South Carolina found on momondo in the last 72 hours is $99.
The fastest flight from Indianapolis to South Carolina takes 1h 40m
Direct flights go from Indianapolis to South Carolina every day.
There are 8 airports near South Carolina: Greenville (GSP), Columbia Metropolitan (CAE), Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Hilton Head Island (HHH), Charlotte Douglas (CLT), Augusta Bush Field (AGS), Charleston (CHS)
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  • When did momondo last update prices for flights from Indianapolis Airport to South Carolina?

    Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Indianapolis Airport to South Carolina?

  • How old do you have to be to fly from Indianapolis Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Indianapolis to South Carolina?

Best airlines flying from Indianapolis to South Carolina

Compare and see reviews for airlines that fly from Indianapolis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
Spirit AirlinesPriceFrom $134Free CancellationRating
6.3
8,049 reviews
Search Spirit Airlines flights
DeltaPriceFrom $197Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $209Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
SouthwestPriceFrom $247Free CancellationRating
8.0
4,246 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Indianapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Indianapolis to South Carolina?

momondo helps you find the best flight between Indianapolis and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Indianapolis to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

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