What airlines fly to South Carolina?

Allegiant Air, American Airlines and Delta are the top three most popular airlines that fly to South Carolina from Indianapolis according to our data. Allegiant Air is the first choice among our users, with 45% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Indianapolis to South Carolina?

United Airlines, Southwest, and Delta are the most popular carriers operating from Indianapolis to South Carolina

How many flights depart from Indianapolis to South Carolina on average per week?

The number of flights available between Indianapolis and South Carolina is 23 per week as of August 2026. The most frequent departure day is Fri, with 22% of weekly flights leaving on this day.

When did momondo last update prices for flights from Indianapolis Airport to South Carolina?

Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Indianapolis Airport to South Carolina?

The number of operators available for flights from Indianapolis Airport to South Carolina is 7 as of August 2026.

How old do you have to be to fly from Indianapolis Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$88 Cheap Flights from Indianapolis to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Indianapolis to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:33 pm - 11:37 amIND Indianapolis-CLT Charlotte Douglas

16h 04m1 stop Orlando

9:40 pm - 9:41 amCLT Charlotte Douglas-IND Indianapolis

12h 01m1 stop Orlando

$172Frontier

mar., sep. 8 - mié., sep. 9

7:33 pm - 3:16 pmIND Indianapolis-CLT Charlotte Douglas

19h 43m1 stop Orlando

9:32 am - 10:25 amCLT Charlotte Douglas-IND Indianapolis

24h 53m1 stop Orlando

$175Frontier

mar., sep. 8 - mar., sep. 15

7:48 pm - 8:38 amIND Indianapolis-CHS Charleston

36h 50m2 stops Atlanta Hartsfield-Jackson Orlando

3:00 pm - 3:14 pmCHS Charleston-IND Indianapolis

24h 14m1 stop Orlando

$184Multiple Airlines

lun., sep. 21 - mar., sep. 29

10:44 am - 8:38 amIND Indianapolis-CHS Charleston

21h 54m1 stop Orlando

3:00 pm - 9:49 amCHS Charleston-IND Indianapolis

18h 49m1 stop Orlando

$185Multiple Airlines

mar., oct. 27 - mar., nov. 10

2:50 pm - 6:40 pmIND Indianapolis-CHS Charleston

3h 50m1 stop Nashville Intl

7:45 am - 11:30 amCHS Charleston-IND Indianapolis

3h 45m1 stop Baltimore/Washington

$216Southwest

sáb., oct. 24 - sáb., oct. 31

5:00 pm - 9:51 pmIND Indianapolis-CHS Charleston

4h 51m1 stop Atlanta Hartsfield-Jackson

5:25 am - 9:36 amCHS Charleston-IND Indianapolis

4h 11m1 stop Atlanta Hartsfield-Jackson

$221Delta

sáb., sep. 5 - mié., sep. 16

5:00 pm - 9:51 pmIND Indianapolis-CHS Charleston

4h 51m1 stop Atlanta Hartsfield-Jackson

7:50 am - 1:30 pmCHS Charleston-IND Indianapolis

5h 40m1 stop Atlanta Hartsfield-Jackson

$221Delta

sáb., sep. 5 - mar., sep. 15

5:30 pm - 10:15 pmIND Indianapolis-CHS Charleston

4h 45m1 stop Baltimore/Washington

5:30 am - 1:00 pmCHS Charleston-IND Indianapolis

7h 30m1 stop Houston Hobby

$221Southwest

lun., nov. 2 - lun., nov. 9

5:49 am - 9:55 amIND Indianapolis-CHS Charleston

4h 06m1 stop Washington, D.C. Dulles Intl

6:00 am - 12:59 pmCHS Charleston-IND Indianapolis

6h 59m1 stop Chicago O'Hare Intl

$221United Airlines

mié., dic. 16 - mié., dic. 30

5:02 pm - 9:41 pmIND Indianapolis-CHS Charleston

4h 39m1 stop Chicago O'Hare Intl

11:27 am - 4:34 pmCHS Charleston-IND Indianapolis

5h 07m1 stop Chicago O'Hare Intl

$221United Airlines

sáb., oct. 17 - sáb., oct. 24

Cheap last minute flights

Enter your travel dates to find the best prices.

9:59 pm - 10:59 amIND Indianapolis-CLT Charlotte Douglas

13h 00m1 stop Dallas/Fort Worth

8:56 am - 9:14 pmCLT Charlotte Douglas-IND Indianapolis

12h 18m1 stop Orlando

$289Frontier

mié., ago. 19 - dom., ago. 23

9:59 pm - 8:01 amIND Indianapolis-CLT Charlotte Douglas

10h 02m1 stop Orlando

8:56 am - 6:38 pmCLT Charlotte Douglas-IND Indianapolis

9h 42m1 stop Orlando

$290Frontier

jue., ago. 20 - mar., ago. 25

12:14 pm - 4:35 pmIND Indianapolis-CAE Columbia Metropolitan

4h 21m1 stop Chicago O'Hare Intl

12:46 pm - 5:58 pmCAE Columbia Metropolitan-IND Indianapolis

5h 12m1 stop Charlotte Douglas

$369American Airlines

mar., ago. 18 - sáb., ago. 22

6:10 am - 2:21 pmIND Indianapolis-CAE Columbia Metropolitan

8h 11m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

10:23 am - 4:33 pmCAE Columbia Metropolitan-IND Indianapolis

6h 10m1 stop Chicago O'Hare Intl

$374United Airlines

mar., ago. 18 - sáb., ago. 22

7:00 am - 2:21 pmIND Indianapolis-CAE Columbia Metropolitan

7h 21m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

2:56 pm - 10:00 pmCAE Columbia Metropolitan-IND Indianapolis

7h 04m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$379United Airlines

mar., ago. 18 - sáb., ago. 22

11:50 am - 3:32 pmIND Indianapolis-HHH Hilton Head Island

3h 42m1 stop Atlanta Hartsfield-Jackson

12:15 pm - 5:45 pmHHH Hilton Head Island-IND Indianapolis

5h 30m1 stop Atlanta Hartsfield-Jackson

$403Delta

jue., ago. 20 - lun., ago. 31

11:50 am - 3:32 pmIND Indianapolis-HHH Hilton Head Island

3h 42m1 stop Atlanta Hartsfield-Jackson

12:15 pm - 7:01 pmHHH Hilton Head Island-IND Indianapolis

6h 46m1 stop Atlanta Hartsfield-Jackson

$403Delta

jue., ago. 20 - jue., ago. 27

11:35 am - 7:45 pmIND Indianapolis-CHS Charleston

8h 10m2 stops Orlando Nashville Intl

1:25 pm - 10:45 pmCHS Charleston-IND Indianapolis

9h 20m2 stops Baltimore/Washington Chicago Midway

$411Southwest

mar., ago. 18 - mar., ago. 25

6:00 am - 11:09 amIND Indianapolis-HHH Hilton Head Island

5h 09m1 stop Charlotte Douglas

12:50 pm - 7:06 pmHHH Hilton Head Island-IND Indianapolis

6h 16m1 stop Chicago O'Hare Intl

$493American Airlines

jue., ago. 20 - sáb., ago. 29

5:00 pm - 9:10 pmIND Indianapolis-CHS Charleston

4h 10m1 stop Chicago Midway

1:25 pm - 10:45 pmCHS Charleston-IND Indianapolis

9h 20m2 stops Baltimore/Washington Chicago Midway

$522Southwest

mié., ago. 19 - mié., ago. 26

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Frontier flights from Indianapolis to South Carolina

Our best Frontier deals on Indianapolis to South Carolina flight tickets

Frontier

Sep 8

IND7:33 pmIndianapolis

16h 04m

1 stop

CLT11:37 amCharlotte Douglas

Sep 9

CLT9:40 pmCharlotte Douglas

12h 01m

1 stop

IND9:41 amIndianapolis

$172

Frontier

Sep 8

IND7:33 pmIndianapolis

19h 43m

1 stop

CLT3:16 pmCharlotte Douglas

Sep 15

CLT9:32 amCharlotte Douglas

24h 53m

1 stop

IND10:25 amIndianapolis

$175

Frontier

Sep 24

IND10:26 amIndianapolis

7h 55m

1 stop

CLT6:21 pmCharlotte Douglas

Sep 26

CLT9:40 pmCharlotte Douglas

11h 51m

1 stop

IND9:31 amIndianapolis

$178

American Airlines flights from Indianapolis to South Carolina

Our best American Airlines deals on Indianapolis to South Carolina flight tickets

American Airlines

Sep 11

IND6:00 amIndianapolis

4h 23m

1 stop

GSP10:23 amGreenville

Sep 17

GSP7:24 amGreenville

6h 37m

1 stop

IND2:01 pmIndianapolis

$256

American Airlines

Sep 12

IND6:57 pmIndianapolis

3h 56m

1 stop

MYR10:53 pmMyrtle Beach Intl

Sep 15

MYR5:45 pmMyrtle Beach Intl

5h 56m

1 stop

IND11:41 pmIndianapolis

$257

American Airlines

Sep 10

IND10:51 amIndianapolis

5h 51m

1 stop

SAV4:42 pmSavannah/Hilton Head

Sep 15

SAV2:19 pmSavannah/Hilton Head

6h 45m

1 stop

IND9:04 pmIndianapolis

$258

momondo Fare Finder

Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisCharlotte

IND Indianapolis - CLT Charlotte Douglas

INDCLT

Indianapolis

mar. 9/8

7:33 pm-11:37 am

1 stop16h 04m

Charlotte Douglas

mié. 9/9

9:40 pm-9:41 am

1 stop12h 01m

$172

IndianapolisCharlotte

IND Indianapolis - CLT Charlotte Douglas

INDCLT

Indianapolis

mar. 9/8

7:33 pm-3:16 pm

1 stop19h 43m

Charlotte Douglas

mar. 9/15

9:32 am-10:25 am

1 stop24h 53m

$175

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

lun. 9/21

7:48 pm-8:38 am

2 stops36h 50m

Charleston

mar. 9/29

3:00 pm-3:14 pm

1 stop24h 14m

$184

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

mar. 10/27

10:44 am-8:38 am

1 stop21h 54m

Charleston

mar. 11/10

3:00 pm-9:49 am

1 stop18h 49m

$185

Quickest round-trip

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

sáb. 10/24

2:50 pm-6:40 pm

1 stop3h 50m

Charleston

sáb. 10/31

7:45 am-11:30 am

1 stop3h 45m

$216

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

sáb. 9/5

5:00 pm-9:51 pm

1 stop4h 51m

Charleston

mié. 9/16

5:25 am-9:36 am

1 stop4h 11m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

sáb. 9/5

5:00 pm-9:51 pm

1 stop4h 51m

Charleston

mar. 9/15

7:50 am-1:30 pm

1 stop5h 40m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

lun. 11/2

5:30 pm-10:15 pm

1 stop4h 45m

Charleston

lun. 11/9

5:30 am-1:00 pm

1 stop7h 30m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

mié. 12/16

5:49 am-9:55 am

1 stop4h 06m

Charleston

mié. 12/30

6:00 am-12:59 pm

1 stop6h 59m

$221

IndianapolisCharleston

IND Indianapolis - CHS Charleston

INDCHS

Indianapolis

sáb. 10/17

5:02 pm-9:41 pm

1 stop4h 39m

Charleston

sáb. 10/24

11:27 am-4:34 pm

1 stop5h 07m

$221

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Indianapolis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indianapolis is in July. Flight prices, which tend to average around $184, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to South Carolina from Indianapolis during June instead. Flights to South Carolina in June, while not as cheap as those in July, still average around $285.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Thursday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $92. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $138.

What is the cheapest Indianapolis to South Carolina flight route?

Fly from Indianapolis to Myrtle Beach Intl for the best Indianapolis - South Carolina flight prices

How far in advance should I book a flight from Indianapolis to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $334 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indianapolis for as low as $245 on momondo.

What cabin class options are available on Indianapolis to South Carolina flights?

There is only 1 cabin class available to choose from on Indianapolis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indianapolis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indianapolis to South Carolina.

Cheap Indianapolis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to South Carolina

Best Price Found	$91
Fastest flight time	1h 41m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Indianapolis in the past 72 hours is $91. The best round-trip flight deal from Indianapolis to South Carolina found on momondo in the last 72 hours is $78.

The fastest flight from Indianapolis to South Carolina takes 1h 41m

Direct flights go from Indianapolis to South Carolina every day.

There are 57 airports in South Carolina. From Indianapolis there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Indianapolis to South Carolina

When did momondo last update prices for flights from Indianapolis Airport to South Carolina?
Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Indianapolis Airport to South Carolina?
The number of operators available for flights from Indianapolis Airport to South Carolina is 7 as of August 2026.
How old do you have to be to fly from Indianapolis Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Indianapolis to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Indianapolis to South Carolina is Airbus A320-100/200, representing 96.55% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 0.86%, Embraer 175 (Enhanced Winglets) at 0.86%, and Embraer 175 at 0.86%.

Best airlines flying from Indianapolis to South Carolina

Compare and see reviews for airlines that fly from Indianapolis to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $74	Free Cancellation	Rating 7.3 676 reviews	Search Allegiant Air flights
Delta	PriceFrom $176	Free Cancellation	Rating 7.8 8,505 reviews	Search Delta flights
American Airlines	PriceFrom $230	Free Cancellation	Rating 7.1 11,947 reviews	Search American Airlines flights
United Airlines	PriceFrom $266	Free Cancellation	Rating 7.4 10,105 reviews	Search United Airlines flights
Southwest	PriceFrom $279	Free Cancellation	Rating 8.0 4,218 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Indianapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Indianapolis to South Carolina?

momondo helps you find the best flight between Indianapolis and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Indianapolis to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.