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Cheap flights from Indianapolis to South Carolina from $68

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 1/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Indianapolis to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 7:46 pm
IND
-
CLT
13h 46m1 stop
Multiple Airlines Logo
6:01 pm - 9:43 am
CLT
-
IND
15h 42m1 stop
$137Multiple Airlines
Sat, Jan 10 - Wed, Jan 14
Multiple Airlines Logo
1:41 pm - 7:51 pm
IND
-
CLT
6h 10m1 stop
Multiple Airlines Logo
6:01 pm - 9:43 am
CLT
-
IND
15h 42m1 stop
$139Multiple Airlines
Fri, Jan 9 - Wed, Jan 14
Multiple Airlines Logo
5:05 pm - 4:42 pm
IND
-
CLT
23h 37m1 stop
Multiple Airlines Logo
6:01 pm - 9:43 am
CLT
-
IND
15h 42m1 stop
$142Multiple Airlines
Mon, Jan 5 - Wed, Jan 14
Allegiant Air Logo
10:11 am - 11:57 am
IND
-
SAV
1h 46mnonstop
Allegiant Air Logo
7:30 am - 9:21 am
SAV
-
IND
1h 51mnonstop
$150Allegiant Air
Mon, Mar 16 - Mon, Mar 23
Spirit Airlines Logo
6:00 am - 4:05 pm
IND
-
CHS
10h 05m1 stop
Spirit Airlines Logo
5:00 pm - 11:25 pm
CHS
-
IND
6h 25m1 stop
$153Spirit Airlines
Thu, Feb 26 - Sat, Feb 28
Spirit Airlines Logo
5:10 am - 5:36 pm
IND
-
CHS
12h 26m1 stop
Spirit Airlines Logo
5:05 pm - 12:18 am
CHS
-
IND
7h 13m1 stop
$156Spirit Airlines
Mon, Feb 2 - Fri, Feb 6
American Airlines Logo
2:15 pm - 8:46 pm
IND
-
CAE
6h 31m1 stop
American Airlines Logo
6:05 am - 1:45 pm
CAE
-
IND
7h 40m1 stop
$231American Airlines
Thu, Jan 8 - Thu, Jan 15
American Airlines Logo
5:04 pm - 11:51 pm
IND
-
GSP
6h 47m2 stops
American Airlines Logo
4:40 pm - 10:54 pm
GSP
-
IND
6h 14m1 stop
$234American Airlines
Sat, Jan 17 - Sun, Jan 18
Delta Logo
12:10 pm - 6:04 pm
IND
-
GSP
5h 54m1 stop
Delta Logo
7:20 am - 11:35 am
GSP
-
IND
4h 15m1 stop
$257Delta
Wed, Jan 21 - Sat, Jan 24
Delta Logo
11:11 am - 4:19 pm
IND
-
AGS
5h 08m1 stop
Delta Logo
5:45 am - 10:05 am
AGS
-
IND
4h 20m1 stop
$257Delta
Wed, Jan 7 - Wed, Jan 14

Southwest flights from Indianapolis to South Carolina

Our best Southwest deals on Indianapolis to South Carolina flight tickets
Southwest
Jan 20
IND5:35 amIndianapolis
5h 00m
1 stop
SAV10:35 amSavannah/Hilton Head
Jan 24
SAV1:25 pmSavannah/Hilton Head
8h 35m
2 stops
IND10:00 pmIndianapolis
$281
Find similar
Southwest
Jan 28
IND7:00 amIndianapolis
10h 35m
2 stops
GSP5:35 pmGreenville
Jan 29
GSP11:15 amGreenville
8h 55m
2 stops
IND8:10 pmIndianapolis
$283
Find similar
Southwest
Jan 12
IND7:00 amIndianapolis
10h 00m
2 stops
MYR5:00 pmMyrtle Beach Intl
Jan 18
MYR3:00 pmMyrtle Beach Intl
7h 05m
1 stop
IND10:05 pmIndianapolis
$284
Find similar

Spirit Airlines flights from Indianapolis to South Carolina

Our best Spirit Airlines deals on Indianapolis to South Carolina flight tickets
Spirit Airlines
Feb 26
IND6:00 amIndianapolis
10h 05m
1 stop
CHS4:05 pmCharleston
Feb 28
CHS5:00 pmCharleston
6h 25m
1 stop
IND11:25 pmIndianapolis
$153
Find similar
Spirit Airlines
Feb 2
IND5:10 amIndianapolis
12h 26m
1 stop
CHS5:36 pmCharleston
Feb 6
CHS5:05 pmCharleston
7h 13m
1 stop
IND12:18 amIndianapolis
$156
Find similar
Spirit Airlines
Jan 8
IND8:26 pmIndianapolis
21h 10m
1 stop
CHS5:36 pmCharleston
Jan 25
CHS6:35 pmCharleston
24h 56m
1 stop
IND7:31 pmIndianapolis
$157
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Sat 1/10

6:00 am-7:46 pm

1 stop13h 46m

Charlotte Douglas

Wed 1/14

6:01 pm-9:43 am

1 stop15h 42m

$137

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Fri 1/9

1:41 pm-7:51 pm

1 stop6h 10m

Charlotte Douglas

Wed 1/14

6:01 pm-9:43 am

1 stop15h 42m

$139

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 1/5

5:05 pm-4:42 pm

1 stop23h 37m

Charlotte Douglas

Wed 1/14

6:01 pm-9:43 am

1 stop15h 42m

$142

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Mon 3/16

10:11 am-11:57 am

Nonstop1h 46m

Savannah/Hilton Head

Mon 3/23

7:30 am-9:21 am

Nonstop1h 51m

$150

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Thu 2/26

6:00 am-4:05 pm

1 stop10h 05m

Charleston

Sat 2/28

5:00 pm-11:25 pm

1 stop6h 25m

$153

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Mon 2/2

5:10 am-5:36 pm

1 stop12h 26m

Charleston

Fri 2/6

5:05 pm-12:18 am

1 stop7h 13m

$156

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

Thu 1/8

2:15 pm-8:46 pm

1 stop6h 31m

Columbia Metropolitan

Thu 1/15

6:05 am-1:45 pm

1 stop7h 40m

$231

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Sat 1/17

5:04 pm-11:51 pm

2 stops6h 47m

Greenville

Sun 1/18

4:40 pm-10:54 pm

1 stop6h 14m

$234

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Wed 1/21

12:10 pm-6:04 pm

1 stop5h 54m

Greenville

Sat 1/24

7:20 am-11:35 am

1 stop4h 15m

$257

IndianapolisAugusta

IND - AGS

INDAGS

Indianapolis

Wed 1/7

11:11 am-4:19 pm

1 stop5h 08m

Augusta Bush Field

Wed 1/14

5:45 am-10:05 am

1 stop4h 20m

$257

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Indianapolis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Indianapolis is in June. Flight prices, which tend to average around $163, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of June, then book flights to South Carolina from Indianapolis during July instead. Flights to South Carolina in July, while not as cheap as those in June, still average around $224.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $45. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $372.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Indianapolis to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $141. Try not to purchase tickets in the evening because they tend to be around $326. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Indianapolis to South Carolina flight route?

Fly from Indianapolis to Charleston for the best Indianapolis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Indianapolis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $318 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Indianapolis for as low as $152 on momondo.

What cabin class options are available on Indianapolis to South Carolina flights?

There is only 1 cabin class available to choose from on Indianapolis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Indianapolis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Indianapolis to South Carolina.

Cheap Indianapolis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Indianapolis to South Carolina

Fastest flight time

1h 43m

Direct flights

Every day

Airports in South Carolina

57 airports
The fastest flight from Indianapolis to South Carolina takes 1h 43m
Direct flights go from Indianapolis to South Carolina every day.
There are 57 airports in South Carolina. From Indianapolis there are direct flights to Savannah/Hilton Head (SAV), Charlotte Douglas (CLT).
Search flight deals

  • When did momondo last update prices for flights from Indianapolis Airport to South Carolina?

    Prices for flights from Indianapolis Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Indianapolis Airport to South Carolina?

  • How old do you have to be to fly from Indianapolis Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Indianapolis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Indianapolis to South Carolina?

Best airlines flying from Indianapolis to South Carolina

Compare and see reviews for airlines that fly from Indianapolis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
Spirit AirlinesPriceFrom $128Free CancellationRating
6.3
8,175 reviews
Search Spirit Airlines flights
DeltaPriceFrom $196Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $209Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
SouthwestPriceFrom $247Free CancellationRating
7.9
4,252 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Indianapolis to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Indianapolis to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Indianapolis to South Carolina with flexible booking policies on momondo?

Yes. All flights to South Carolina from Indianapolis on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Indianapolis to South Carolina?

momondo helps you find the best flight between Indianapolis and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Indianapolis to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Indianapolis to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

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