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Cheap flights from Illinois to Florence from $225

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Illinois to Florence departing on 10/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Illinois to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:35 am - 2:12 pmSTL  Lambert-St Louis-FLO Florence
5h 37m1 stop Charlotte Douglas
American Airlines Logo
5:09 am - 8:30 amFLO  Florence-STL Lambert-St Louis
4h 21m1 stop Charlotte Douglas
$333American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
8:05 am - 3:09 pmORD  Chicago O'Hare Intl-FLO Florence
6h 04m1 stop Charlotte Douglas
American Airlines Logo
6:24 am - 11:00 amFLO  Florence-ORD Chicago O'Hare Intl
5h 36m1 stop Charlotte Douglas
$355American Airlines
Wed, Nov 4 - Tue, Nov 10
American Airlines Logo
6:49 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
6h 23m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$355American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
4:05 pm - 10:59 pmMLI  Moline Quad-City-FLO Florence
5h 54m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 12:05 amFLO  Florence-MLI Moline Quad-City
11h 22m2 stops Charlotte Douglas Chicago O'Hare Intl
$396American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
11:43 am - 10:59 pmMLI  Moline Quad-City-FLO Florence
10h 16m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
1:43 pm - 12:05 amFLO  Florence-MLI Moline Quad-City
11h 22m2 stops Charlotte Douglas Chicago O'Hare Intl
$401American Airlines
Tue, Sep 8 - Tue, Sep 15
American Airlines Logo
6:49 am - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
6h 23m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$435American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
1:22 pm - 9:20 pmORD  Chicago O'Hare Intl-FLO Florence
6h 58m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 7:38 pmFLO  Florence-ORD Chicago O'Hare Intl
6h 55m1 stop Charlotte Douglas
$498American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
10:44 pm - 2:12 pmORD  Chicago O'Hare Intl-FLO Florence
14h 28m2 stops Lambert-St Louis Charlotte Douglas
American Airlines Logo
1:43 pm - 5:38 pmFLO  Florence-ORD Chicago O'Hare Intl
4h 55m1 stop Charlotte Douglas
$513American Airlines
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
6:36 am - 9:20 pmSTL  Lambert-St Louis-FLO Florence
13h 44m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:09 am - 8:30 amFLO  Florence-STL Lambert-St Louis
4h 21m1 stop Charlotte Douglas
$526American Airlines
Sun, Sep 6 - Sun, Sep 13
American Airlines Logo
4:45 pm - 10:43 pmORD  Chicago O'Hare Intl-FLO Florence
4h 58m1 stop Charlotte Douglas
American Airlines Logo
6:20 pm - 12:02 amFLO  Florence-ORD Chicago O'Hare Intl
6h 42m1 stop Charlotte Douglas
$550American Airlines
Sun, Jan 17 - Sat, Mar 27

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American Airlines flights from Illinois to Florence, South Carolina

Our best American Airlines deals on Illinois to Florence, South Carolina flight tickets
American Airlines
Sep 6
STL7:35 amLambert-St Louis
5h 37m
1 stop
FLO2:12 pmFlorence
Sep 13
FLO5:09 amFlorence
4h 21m
1 stop
STL8:30 amLambert-St Louis
$333
American Airlines
Sep 5
ORD6:49 amChicago O'Hare Intl
6h 23m
1 stop
FLO2:12 pmFlorence
Sep 12
FLO1:43 pmFlorence
4h 55m
1 stop
ORD5:38 pmChicago O'Hare Intl
$355
American Airlines
Sep 8
MLI4:05 pmMoline Quad-City
5h 54m
1 stop
FLO10:59 pmFlorence
Sep 15
FLO1:43 pmFlorence
11h 22m
2 stops
MLI12:05 amMoline Quad-City
$396

momondo Fare Finder

 
Customize your flight search to find flights from Illinois to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Illinois to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Sun 9/6

7:35 am-2:12 pm

1 stop5h 37m

Florence

Sun 9/13

5:09 am-8:30 am

1 stop4h 21m

$333

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Wed 11/4

8:05 am-3:09 pm

1 stop6h 04m

Florence

Tue 11/10

6:24 am-11:00 am

1 stop5h 36m

$355

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:49 am-2:12 pm

1 stop6h 23m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$355

MolineFlorence

MLI Moline Quad-City - FLO Florence

MLIFLO

Moline Quad-City

Tue 9/8

4:05 pm-10:59 pm

1 stop5h 54m

Florence

Tue 9/15

1:43 pm-12:05 am

2 stops11h 22m

$396

MolineFlorence

MLI Moline Quad-City - FLO Florence

MLIFLO

Moline Quad-City

Tue 9/8

11:43 am-10:59 pm

2 stops10h 16m

Florence

Tue 9/15

1:43 pm-12:05 am

2 stops11h 22m

$401

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

6:49 am-2:12 pm

1 stop6h 23m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$435

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

1:22 pm-9:20 pm

1 stop6h 58m

Florence

Fri 9/11

1:43 pm-7:38 pm

1 stop6h 55m

$498

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sat 9/5

10:44 pm-2:12 pm

2 stops14h 28m

Florence

Sat 9/12

1:43 pm-5:38 pm

1 stop4h 55m

$513

St. LouisFlorence

STL Lambert-St Louis - FLO Florence

STLFLO

Lambert-St Louis

Sun 9/6

6:36 am-9:20 pm

2 stops13h 44m

Florence

Sun 9/13

5:09 am-8:30 am

1 stop4h 21m

$526

ChicagoFlorence

ORD Chicago O'Hare Intl - FLO Florence

ORDFLO

Chicago O'Hare Intl

Sun 1/17

4:45 pm-10:43 pm

1 stop4h 58m

Florence

Sat 3/27

6:20 pm-12:02 am

1 stop6h 42m

$550

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Illinois to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Illinois to Florence, South Carolina flights?

You could potentially save up to 57% on your flight if you consider stops on a Illinois to Florence, South Carolina flight.

Cheap Illinois to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Illinois to Florence, South Carolina

Fastest flight time

5h 35m

Direct flights

None
The fastest flight from Illinois to Florence, South Carolina takes 5h 35m
There are no direct flights from Illinois to Florence, South Carolina. There are no popular flight routes from Illinois to Florence, South Carolina.
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Frequently asked questions about flying from Illinois to Florence, South Carolina

  • When did momondo last update prices for flights from Illinois to Florence Airport?

    Prices for flights from Illinois to Florence Airport are updated daily.

  • How many operators does momondo search for flights from Illinois to Florence Airport?

  • How old do you have to be to fly from Illinois to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Illinois to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Illinois to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Illinois to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Illinois to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Illinois with this policy.

How can momondo help me find flights from Illinois to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Illinois to Florence.

I’m not ready to book a flight from Illinois to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Illinois to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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