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Cheap flights from Illinois to Florence from $354

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Illinois to Florence departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Illinois to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:52 pm - 11:08 pm
STL
-
FLO
4h 16m
1 stop
American Airlines Logo
5:16 am - 12:33 pm
FLO
-
STL
8h 17m
2 stops
$354American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
9:37 am - 5:21 pm
STL
-
FLO
6h 44m
2 stops
American Airlines Logo
5:16 am - 12:33 pm
FLO
-
STL
8h 17m
2 stops
$359American Airlines
Wed, Feb 18 - Sun, Feb 22
American Airlines Logo
5:00 pm - 11:57 pm
ORD
-
FLO
5h 57m
1 stop
American Airlines Logo
5:16 am - 9:08 am
FLO
-
ORD
4h 52m
1 stop
$401American Airlines
Mon, Mar 30 - Thu, Apr 2
American Airlines Logo
5:00 pm - 11:57 pm
ORD
-
FLO
5h 57m
1 stop
American Airlines Logo
5:16 am - 12:16 pm
FLO
-
ORD
8h 00m
2 stops
$406American Airlines
Mon, Mar 30 - Thu, Apr 2
American Airlines Logo
10:28 am - 5:21 pm
ORD
-
FLO
5h 53m
1 stop
American Airlines Logo
5:16 am - 9:05 am
FLO
-
ORD
4h 49m
1 stop
$457American Airlines
Wed, Feb 18 - Fri, Feb 20
American Airlines Logo
6:22 pm - 11:08 pm
ORD
-
FLO
3h 46m
1 stop
American Airlines Logo
5:16 am - 12:05 pm
FLO
-
ORD
7h 49m
2 stops
$462American Airlines
Wed, Feb 18 - Fri, Feb 20
American Airlines Logo
9:40 am - 5:21 pm
ORD
-
FLO
6h 41m
2 stops
American Airlines Logo
5:16 am - 12:22 pm
FLO
-
ORD
8h 06m
2 stops
$468American Airlines
Wed, Feb 18 - Fri, Feb 20
American Airlines Logo
6:48 pm - 11:57 pm
ORD
-
FLO
4h 09m
1 stop
American Airlines Logo
6:15 am - 12:16 pm
FLO
-
ORD
7h 01m
2 stops
$482American Airlines
Sat, Mar 28 - Tue, Mar 31
American Airlines Logo
6:00 am - 5:21 pm
MLI
-
FLO
10h 21m
2 stops
American Airlines Logo
6:25 pm - 9:58 pm
FLO
-
MLI
4h 33m
1 stop
$498American Airlines
Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
6:00 am - 5:21 pm
MLI
-
FLO
10h 21m
2 stops
American Airlines Logo
5:16 am - 1:21 pm
FLO
-
MLI
9h 05m
2 stops
$503American Airlines
Tue, Feb 17 - Sat, Feb 21

American Airlines flights from Illinois to Florence, South Carolina

Our best American Airlines deals on Illinois to Florence, South Carolina flight tickets
American Airlines
Feb 18
STL5:52 pmLambert-St Louis
4h 16m
1 stop
FLO11:08 pmFlorence
Feb 22
FLO5:16 amFlorence
8h 17m
2 stops
STL12:33 pmLambert-St Louis
$354
American Airlines
Feb 18
STL9:37 amLambert-St Louis
6h 44m
2 stops
FLO5:21 pmFlorence
Feb 22
FLO5:16 amFlorence
8h 17m
2 stops
STL12:33 pmLambert-St Louis
$359
American Airlines
Mar 30
ORD5:00 pmChicago O'Hare Intl
5h 57m
1 stop
FLO11:57 pmFlorence
Apr 2
FLO5:16 amFlorence
4h 52m
1 stop
ORD9:08 amChicago O'Hare Intl
$401

momondo Fare Finder

 
Customize your flight search to find flights from Illinois to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Illinois to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/18

5:52 pm-11:08 pm

1 stop4h 16m

Florence

Sun 2/22

5:16 am-12:33 pm

2 stops8h 17m

$354

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/18

9:37 am-5:21 pm

2 stops6h 44m

Florence

Sun 2/22

5:16 am-12:33 pm

2 stops8h 17m

$359

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 3/30

5:00 pm-11:57 pm

1 stop5h 57m

Florence

Thu 4/2

5:16 am-9:08 am

1 stop4h 52m

$401

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Mon 3/30

5:00 pm-11:57 pm

1 stop5h 57m

Florence

Thu 4/2

5:16 am-12:16 pm

2 stops8h 00m

$406

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 2/18

10:28 am-5:21 pm

1 stop5h 53m

Florence

Fri 2/20

5:16 am-9:05 am

1 stop4h 49m

$457

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 2/18

6:22 pm-11:08 pm

1 stop3h 46m

Florence

Fri 2/20

5:16 am-12:05 pm

2 stops7h 49m

$462

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 2/18

9:40 am-5:21 pm

2 stops6h 41m

Florence

Fri 2/20

5:16 am-12:22 pm

2 stops8h 06m

$468

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 3/28

6:48 pm-11:57 pm

1 stop4h 09m

Florence

Tue 3/31

6:15 am-12:16 pm

2 stops7h 01m

$482

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Tue 2/17

6:00 am-5:21 pm

2 stops10h 21m

Florence

Sat 2/21

6:25 pm-9:58 pm

1 stop4h 33m

$498

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Tue 2/17

6:00 am-5:21 pm

2 stops10h 21m

Florence

Sat 2/21

5:16 am-1:21 pm

2 stops9h 05m

$503

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Illinois to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Illinois according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Illinois to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Illinois to Florence, South Carolina

Fastest flight time

4h 09m

Direct flights

None
The fastest flight from Illinois to Florence, South Carolina takes 4h 09m
There are no direct flights from Illinois to Florence, South Carolina. There are no popular flight routes from Illinois to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Illinois to Florence Airport?

    Prices for flights from Illinois to Florence Airport are updated daily.

  • How old do you have to be to fly from Illinois to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Illinois to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Illinois to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Illinois to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Illinois to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Illinois with this policy.

How can momondo help me find flights from Illinois to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Illinois to Florence.

I’m not ready to book a flight from Illinois to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Illinois to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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