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Cheap flights from Illinois to Florence from $279

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Illinois to Florence departing on 5/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Illinois to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:45 pm - 10:00 pm
ORD
-
FLO
4h 15m
1 stop
American Airlines Logo
2:35 pm - 7:48 pm
FLO
-
ORD
6h 13m
1 stop
$279American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
6:00 am - 2:09 pm
ORD
-
FLO
7h 09m
2 stops
American Airlines Logo
11:20 am - 3:38 pm
FLO
-
ORD
5h 18m
1 stop
$284American Airlines
Tue, Sep 1 - Tue, Sep 15
American Airlines Logo
3:32 pm - 12:02 am
ORD
-
FLO
7h 30m
2 stops
American Airlines Logo
5:31 am - 12:02 pm
FLO
-
ORD
7h 31m
2 stops
$289American Airlines
Tue, Sep 1 - Tue, Sep 15
American Airlines Logo
4:21 pm - 9:47 pm
ORD
-
FLO
4h 26m
1 stop
American Airlines Logo
5:20 am - 8:30 am
FLO
-
ORD
4h 10m
1 stop
$309American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
12:42 pm - 9:47 pm
ORD
-
FLO
8h 05m
2 stops
American Airlines Logo
5:20 am - 10:44 am
FLO
-
ORD
6h 24m
1 stop
$314American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
1:25 pm - 9:47 pm
ORD
-
FLO
7h 22m
2 stops
American Airlines Logo
5:20 am - 11:08 am
FLO
-
ORD
6h 48m
2 stops
$319American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
10:28 am - 5:50 pm
ORD
-
FLO
6h 22m
1 stop
American Airlines Logo
4:16 pm - 7:22 pm
FLO
-
ORD
4h 06m
1 stop
$339American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
4:04 pm - 11:57 pm
ORD
-
FLO
6h 53m
2 stops
American Airlines Logo
4:16 pm - 7:22 pm
FLO
-
ORD
4h 06m
1 stop
$344American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
6:53 pm - 11:57 pm
STL
-
FLO
4h 04m
1 stop
American Airlines Logo
4:16 pm - 7:30 pm
FLO
-
STL
4h 14m
1 stop
$385American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
6:53 pm - 11:57 pm
STL
-
FLO
4h 04m
1 stop
American Airlines Logo
5:20 am - 12:48 pm
FLO
-
STL
8h 28m
2 stops
$390American Airlines
Sat, Apr 4 - Wed, Apr 8

American Airlines flights from Illinois to Florence, South Carolina

Our best American Airlines deals on Illinois to Florence, South Carolina flight tickets
American Airlines
May 23
ORD4:45 pmChicago O'Hare Intl
4h 15m
1 stop
FLO10:00 pmFlorence
May 30
FLO2:35 pmFlorence
6h 13m
1 stop
ORD7:48 pmChicago O'Hare Intl
$279
American Airlines
Sep 1
ORD6:00 amChicago O'Hare Intl
7h 09m
2 stops
FLO2:09 pmFlorence
Sep 15
FLO11:20 amFlorence
5h 18m
1 stop
ORD3:38 pmChicago O'Hare Intl
$284
American Airlines
Sep 1
ORD3:32 pmChicago O'Hare Intl
7h 30m
2 stops
FLO12:02 amFlorence
Sep 15
FLO5:31 amFlorence
7h 31m
2 stops
ORD12:02 pmChicago O'Hare Intl
$289

momondo Fare Finder

 
Customize your flight search to find flights from Illinois to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Illinois to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/23

4:45 pm-10:00 pm

1 stop4h 15m

Florence

Sat 5/30

2:35 pm-7:48 pm

1 stop6h 13m

$279

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/1

6:00 am-2:09 pm

2 stops7h 09m

Florence

Tue 9/15

11:20 am-3:38 pm

1 stop5h 18m

$284

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/1

3:32 pm-12:02 am

2 stops7h 30m

Florence

Tue 9/15

5:31 am-12:02 pm

2 stops7h 31m

$289

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/18

4:21 pm-9:47 pm

1 stop4h 26m

Florence

Sat 4/25

5:20 am-8:30 am

1 stop4h 10m

$309

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/18

12:42 pm-9:47 pm

2 stops8h 05m

Florence

Sat 4/25

5:20 am-10:44 am

1 stop6h 24m

$314

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/18

1:25 pm-9:47 pm

2 stops7h 22m

Florence

Sat 4/25

5:20 am-11:08 am

2 stops6h 48m

$319

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/4

10:28 am-5:50 pm

1 stop6h 22m

Florence

Wed 4/8

4:16 pm-7:22 pm

1 stop4h 06m

$339

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 4/4

4:04 pm-11:57 pm

2 stops6h 53m

Florence

Wed 4/8

4:16 pm-7:22 pm

1 stop4h 06m

$344
Quickest round-trip

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 4/4

6:53 pm-11:57 pm

1 stop4h 04m

Florence

Wed 4/8

4:16 pm-7:30 pm

1 stop4h 14m

$385

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Sat 4/4

6:53 pm-11:57 pm

1 stop4h 04m

Florence

Wed 4/8

5:20 am-12:48 pm

2 stops8h 28m

$390

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Illinois to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Illinois according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

Cheap Illinois to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Illinois to Florence, South Carolina

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Illinois to Florence, South Carolina takes 4h 00m
There are no direct flights from Illinois to Florence, South Carolina. There are no popular flight routes from Illinois to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Illinois to Florence Airport?

    Prices for flights from Illinois to Florence Airport are updated daily.

  • How old do you have to be to fly from Illinois to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Illinois to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Illinois to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Illinois to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Illinois to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Illinois with this policy.

How can momondo help me find flights from Illinois to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Illinois to Florence.

I’m not ready to book a flight from Illinois to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Illinois to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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