Cheap flights from Houston to St. Louis from $65

In general, September is the cheapest month to fly from Houston to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $249. The month of October is another great option to travel to St. Louis, with average flight prices from Houston averaging around $262.

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $290. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $410. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Houston in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $336 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $377 per ticket.

Fly from Houston Hobby to Lambert-St Louis for the best Houston - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Houston when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $349 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Houston for as low as $197 on momondo.

There are 3 cabin classes available to choose from on Houston to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, United Airlines, and Frontier are the most popular carriers operating from Houston to Lambert-St Louis

Southwest, United Airlines and Frontier are the top three most popular airlines that fly to St. Louis from Houston according to our data. Southwest is the first choice among our users, with 41% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 4 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

The number of flights available between Houston and St. Louis is 16 per day as of March 2026. The most frequent departure time is 1:00PM, with 40% of daily flights leaving in the afternoon.

The number of flights available between Houston and St. Louis is 118 per week as of March 2026. The most frequent departure day is Mon, with 17% of weekly flights leaving on this day.