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Cheap flights from Harrisburg to St. Louis from $159

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to St. Louis departing on 10/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Harrisburg to St. Louis

Cheap round-trip flights

Frontier Logo
11:07 am - 8:37 pmMDT-STL
10h 30m1 stop
Frontier Logo
1:57 pm - 10:02 amSTL-MDT
19h 05m1 stop
$159Frontier
Find Deal
Fri, Oct 3 - Sun, Oct 5
American Airlines Logo
4:36 pm - 9:06 pmMDT-STL
5h 30m1 stop
American Airlines Logo
5:27 am - 12:03 pmSTL-MDT
5h 36m1 stop
$249American Airlines
Find Deal
Fri, Sep 19 - Sun, Sep 21
American Airlines Logo
6:30 am - 12:23 pmMDT-STL
6h 53m1 stop
American Airlines Logo
6:05 am - 11:01 amSTL-MDT
3h 56m1 stop
$259American Airlines
Find Deal
Wed, Sep 10 - Sun, Sep 14
American Airlines Logo
5:40 am - 9:35 amMDT-STL
4h 55m1 stop
American Airlines Logo
6:45 pm - 12:19 amSTL-MDT
4h 34m1 stop
$274American Airlines
Find Deal
Wed, Nov 5 - Sun, Nov 9
Delta Logo
6:00 am - 10:26 amMDT-STL
5h 26m1 stop
Delta Logo
5:15 pm - 11:08 pmSTL-MDT
4h 53m1 stop
$279Delta
Find Deal
Thu, Oct 9 - Mon, Oct 13
United Airlines Logo
10:55 am - 3:44 pmMDT-STL
5h 49m1 stop
United Airlines Logo
8:15 am - 1:48 pmSTL-MDT
4h 33m1 stop
$316United Airlines
Find Deal
Thu, Sep 18 - Sun, Sep 21
Delta Logo
6:00 am - 10:26 amMDT-STL
5h 26m1 stop
Delta Logo
6:40 am - 11:53 amSTL-MDT
4h 13m1 stop
$318Delta
Find Deal
Thu, Oct 9 - Sun, Oct 12
Logo
5:25 pm - 10:12 amMDT-STL
17h 47m2 stops
Logo
2:12 pm - 10:48 amSTL-MDT
19h 36m1 stop
$402
Find Deal
Wed, Nov 5 - Sun, Nov 9
United Airlines Logo
6:45 am - 10:40 amMDT-STL
4h 55m1 stop
United Airlines Logo
3:20 pm - 9:15 pmSTL-MDT
4h 55m1 stop
$435United Airlines
Find Deal
Wed, Sep 10 - Sun, Sep 14
Logo
4:57 pm - 1:02 pmMDT-STL
21h 05m1 stop
Logo
9:35 pm - 11:27 amSTL-MDT
36h 52m2 stops
$517
Find Deal
Sun, Sep 7 - Fri, Sep 12

American Airlines flights from Harrisburg to St. Louis

Our best American Airlines deals on Harrisburg to St. Louis flight tickets
American Airlines
Sep 19
MDT4:36 pmHarrisburg
5h 30m
1 stop
STL9:06 pmLambert-St Louis
Sep 21
STL5:27 amLambert-St Louis
5h 36m
1 stop
MDT12:03 pmHarrisburg
$249
Find similar
American Airlines
Sep 4
MDT6:40 amHarrisburg
7h 32m
1 stop
STL1:12 pmLambert-St Louis
Sep 12
STL2:11 pmLambert-St Louis
7h 31m
1 stop
MDT10:42 pmHarrisburg
$255
Find similar
American Airlines
Sep 10
MDT6:30 amHarrisburg
6h 53m
1 stop
STL12:23 pmLambert-St Louis
Sep 14
STL6:05 amLambert-St Louis
3h 56m
1 stop
MDT11:01 amHarrisburg
$259
Find similar

Delta flights from Harrisburg to St. Louis

Our best Delta deals on Harrisburg to St. Louis flight tickets
Delta
Oct 9
MDT6:00 amHarrisburg
5h 26m
1 stop
STL10:26 amLambert-St Louis
Oct 13
STL5:15 pmLambert-St Louis
4h 53m
1 stop
MDT11:08 pmHarrisburg
$279
Find similar
Delta
Sep 4
MDT12:33 pmHarrisburg
7h 34m
2 stops
STL7:07 pmLambert-St Louis
Sep 12
STL9:19 amLambert-St Louis
7h 09m
1 stop
MDT5:28 pmHarrisburg
$303
Find similar
Delta
Oct 9
MDT6:00 amHarrisburg
5h 26m
1 stop
STL10:26 amLambert-St Louis
Oct 12
STL6:40 amLambert-St Louis
4h 13m
1 stop
MDT11:53 amHarrisburg
$318
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Harrisburg to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 10/3

11:07 am-8:37 pm

1 stop10h 30m

Lambert-St Louis

Sun 10/5

1:57 pm-10:02 am

1 stop19h 05m

$159

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Fri 9/19

4:36 pm-9:06 pm

1 stop5h 30m

Lambert-St Louis

Sun 9/21

5:27 am-12:03 pm

1 stop5h 36m

$249

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 9/10

6:30 am-12:23 pm

1 stop6h 53m

Lambert-St Louis

Sun 9/14

6:05 am-11:01 am

1 stop3h 56m

$259

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 11/5

5:40 am-9:35 am

1 stop4h 55m

Lambert-St Louis

Sun 11/9

6:45 pm-12:19 am

1 stop4h 34m

$274

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 10/9

6:00 am-10:26 am

1 stop5h 26m

Lambert-St Louis

Mon 10/13

5:15 pm-11:08 pm

1 stop4h 53m

$279

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 9/18

10:55 am-3:44 pm

1 stop5h 49m

Lambert-St Louis

Sun 9/21

8:15 am-1:48 pm

1 stop4h 33m

$316

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Thu 10/9

6:00 am-10:26 am

1 stop5h 26m

Lambert-St Louis

Sun 10/12

6:40 am-11:53 am

1 stop4h 13m

$318

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 11/5

5:25 pm-10:12 am

2 stops17h 47m

Lambert-St Louis

Sun 11/9

2:12 pm-10:48 am

1 stop19h 36m

$402

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Wed 9/10

6:45 am-10:40 am

1 stop4h 55m

Lambert-St Louis

Sun 9/14

3:20 pm-9:15 pm

1 stop4h 55m

$435

HarrisburgSt. Louis

MDT - STL

MDTSTL

Harrisburg

Sun 9/7

4:57 pm-1:02 pm

1 stop21h 05m

Lambert-St Louis

Fri 9/12

9:35 pm-11:27 am

2 stops36h 52m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Harrisburg to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Harrisburg to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $288. The month of April is another great option to travel to St. Louis, with average flight prices from Harrisburg averaging around $291.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $318. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $762. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Harrisburg at noon is the least expensive time of day to depart. momondo users have found prices as low as $325 when looking at flights departing at noon. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $389 per ticket.

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Harrisburg when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Harrisburg for as low as $262 on momondo.

How have Harrisburg to St. Louis flight prices changed over time?

When to book flights from Harrisburg to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to St. Louis (MDT to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to St. Louis

Direct flights

None
There are no direct flights from Harrisburg to St. Louis. There are no popular flight routes from Harrisburg to St. Louis.
Search flight deals

  • How far is Harrisburg to Lambert-St Louis by plane?

    There are 718.1 mi between Harrisburg and Lambert-St Louis. Typically, this will take 4h 15m by plane in normal conditions.

  • When did momondo last update prices for flights from Harrisburg Airport to Lambert-St Louis Airport?

    Prices for flights from Harrisburg Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Harrisburg Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Harrisburg Airport to Lambert-St Louis Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Harrisburg Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Harrisburg to St. Louis?

Best airlines flying from Harrisburg to St. Louis

Compare and see reviews for airlines that fly from Harrisburg to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $238Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,945 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Farmington
Festus
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to St. Louis?

Finding the right flight to St. Louis from Harrisburg is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Harrisburg to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Harrisburg to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from Harrisburg to St. Louis?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Harrisburg to St. Louis.

I’m not ready to book a flight from Harrisburg to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from Harrisburg are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your St. Louis trip

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