What airlines fly to South Carolina?

Southwest, American Airlines and Allegiant Air are the top three most popular airlines that fly to South Carolina from Harrisburg according to our data. Southwest is the first choice among our users, with 47% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Harrisburg to South Carolina?

Allegiant Air, American Airlines, and United Airlines are the most popular carriers operating from Harrisburg to South Carolina

When did momondo last update prices for flights from Harrisburg Airport to South Carolina?

Prices for flights from Harrisburg Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Harrisburg Airport to South Carolina?

As of October 2026, there are 4 operators available to choose from for flights from Harrisburg Airport to South Carolina.

How old do you have to be to fly from Harrisburg Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Harrisburg Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$49 Cheap Flights from Harrisburg to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Harrisburg to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

4:05 pm - 5:35 pmMDT Harrisburg-MYR Myrtle Beach Intl

1h 30mnonstop

6:25 pm - 8:01 pmMYR Myrtle Beach Intl-MDT Harrisburg

1h 36mnonstop

$125Allegiant Air

Sun, Oct 25 - Thu, Oct 29

3:58 pm - 5:28 pmMDT Harrisburg-MYR Myrtle Beach Intl

1h 30mnonstop

6:25 pm - 8:01 pmMYR Myrtle Beach Intl-MDT Harrisburg

1h 36mnonstop

$133Allegiant Air

Sun, Oct 18 - Thu, Oct 22

7:32 pm - 8:38 amMDT Harrisburg-CHS Charleston

13h 06m1 stop Orlando Sanford Intl

9:39 pm - 9:03 amCHS Charleston-MDT Harrisburg

11h 24m1 stop Tampa

$287Multiple Airlines

Mon, Nov 2 - Thu, Nov 5

8:51 pm - 8:45 amMDT Harrisburg-MYR Myrtle Beach Intl

11h 54m1 stop Orlando Sanford Intl

6:25 pm - 8:01 pmMYR Myrtle Beach Intl-MDT Harrisburg

1h 36mnonstop

$296Multiple Airlines

Thu, Oct 22 - Thu, Oct 29

2:38 pm - 7:11 pmMDT Harrisburg-CHS Charleston

4h 33m1 stop Washington, D.C. Dulles Intl

12:30 pm - 6:57 pmCHS Charleston-MDT Harrisburg

6h 27m1 stop Chicago O'Hare Intl

$305United Airlines

Tue, Nov 10 - Sat, Nov 14

6:23 pm - 11:59 pmMDT Harrisburg-CHS Charleston

5h 36m1 stop Atlanta Hartsfield-Jackson

5:49 pm - 11:50 pmCHS Charleston-MDT Harrisburg

6h 01m1 stop Atlanta Hartsfield-Jackson

$305Delta

Tue, Nov 10 - Sat, Nov 14

9:39 am - 3:36 pmMDT Harrisburg-GSP Greenville

5h 57m1 stop Philadelphia

8:35 pm - 12:13 amGSP Greenville-MDT Harrisburg

3h 38m1 stop Charlotte Douglas

$319American Airlines

Thu, Nov 19 - Mon, Nov 23

12:45 pm - 7:09 pmMDT Harrisburg-GSP Greenville

6h 24m1 stop Charlotte Douglas

7:40 pm - 11:22 pmGSP Greenville-MDT Harrisburg

3h 42m1 stop Charlotte Douglas

$319American Airlines

Sat, Dec 12 - Mon, Dec 14

6:33 pm - 11:47 pmMDT Harrisburg-GSP Greenville

5h 14m1 stop Atlanta Hartsfield-Jackson

7:25 pm - 11:48 pmGSP Greenville-MDT Harrisburg

4h 23m1 stop Atlanta Hartsfield-Jackson

$319Delta

Fri, Dec 4 - Mon, Dec 7

6:30 am - 1:46 pmMDT Harrisburg-CHS Charleston

7h 16m1 stop Chicago O'Hare Intl

2:30 pm - 6:28 pmCHS Charleston-MDT Harrisburg

3h 58m1 stop Washington, D.C. Dulles Intl

$368United Airlines

Fri, Jan 15 - Tue, Jan 19

Cheap last minute flights

Enter your travel dates to find the best prices.

6:00 am - 11:35 amMDT Harrisburg-CHS Charleston

5h 35m1 stop Atlanta Hartsfield-Jackson

12:40 pm - 5:19 pmCHS Charleston-MDT Harrisburg

4h 39m1 stop Atlanta Hartsfield-Jackson

$381Delta

Wed, Oct 7 - Wed, Oct 14

6:00 am - 10:10 amMDT Harrisburg-CHS Charleston

4h 10m1 stop Atlanta Hartsfield-Jackson

5:35 pm - 11:39 pmCHS Charleston-MDT Harrisburg

6h 04m1 stop Atlanta Hartsfield-Jackson

$381Delta

Wed, Oct 7 - Wed, Oct 14

10:02 am - 2:03 pmMDT Harrisburg-CAE Columbia Metropolitan

4h 01m1 stop Charlotte Douglas

5:00 am - 9:11 amCAE Columbia Metropolitan-MDT Harrisburg

4h 11m1 stop Charlotte Douglas

$389American Airlines

Thu, Oct 8 - Sun, Oct 11

7:00 pm - 11:56 pmMDT Harrisburg-CAE Columbia Metropolitan

4h 56m1 stop Charlotte Douglas

5:00 am - 9:11 amCAE Columbia Metropolitan-MDT Harrisburg

4h 11m1 stop Charlotte Douglas

$389American Airlines

Fri, Oct 9 - Sun, Oct 11

6:43 am - 12:06 pmMDT Harrisburg-CAE Columbia Metropolitan

5h 23m1 stop Philadelphia

5:00 am - 9:11 amCAE Columbia Metropolitan-MDT Harrisburg

4h 11m1 stop Charlotte Douglas

$389American Airlines

Thu, Oct 8 - Mon, Oct 12

6:06 pm - 10:51 pmMDT Harrisburg-CHS Charleston

4h 45m1 stop Atlanta Hartsfield-Jackson

6:29 pm - 11:39 pmCHS Charleston-MDT Harrisburg

5h 10m1 stop Atlanta Hartsfield-Jackson

$405Delta

Fri, Oct 9 - Sat, Oct 10

2:55 pm - 7:05 pmMDT Harrisburg-CHS Charleston

4h 10m1 stop Washington, D.C. Dulles Intl

7:53 pm - 11:29 pmCHS Charleston-MDT Harrisburg

3h 36m1 stop Washington, D.C. Dulles Intl

$620United Airlines

Wed, Oct 7 - Wed, Oct 14

4:41 pm - 4:11 pmMDT Harrisburg-CHS Charleston

23h 30m2 stops Tampa St. Petersburg Fort Lauderdale

6:00 am - 3:51 pmCHS Charleston-MDT Harrisburg

9h 51m1 stop Tampa

$653Multiple Airlines

Wed, Oct 7 - Wed, Oct 14

6:30 am - 1:33 pmMDT Harrisburg-GSP Greenville

7h 03m1 stop Chicago O'Hare Intl

6:00 am - 11:29 pmGSP Greenville-MDT Harrisburg

17h 29m2 stops Newark Washington, D.C. Dulles Intl

$718United Airlines

Sat, Oct 10 - Sun, Oct 11

9:11 pm - 11:44 amMDT Harrisburg-MYR Myrtle Beach Intl

14h 33m1 stop Tampa St. Petersburg

1:51 pm - 10:30 amMYR Myrtle Beach Intl-MDT Harrisburg

20h 39m2 stops Columbus Rickenbacker Punta Gorda

$725Multiple Airlines

Fri, Oct 9 - Mon, Oct 12

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United Airlines flights from Harrisburg to South Carolina

Our best United Airlines deals on Harrisburg to South Carolina flight tickets

United Airlines

Nov 10

MDT2:38 pmHarrisburg

4h 33m

1 stop

CHS7:11 pmCharleston

Nov 14

CHS12:30 pmCharleston

6h 27m

1 stop

MDT6:57 pmHarrisburg

$305

United Airlines

Jan 15

MDT6:30 amHarrisburg

7h 16m

1 stop

CHS1:46 pmCharleston

Jan 19

CHS2:30 pmCharleston

3h 58m

1 stop

MDT6:28 pmHarrisburg

$368

United Airlines

Jan 9

MDT10:35 amHarrisburg

3h 38m

1 stop

CHS2:13 pmCharleston

Jan 13

CHS6:00 amCharleston

7h 30m

1 stop

MDT1:30 pmHarrisburg

$405

American Airlines flights from Harrisburg to South Carolina

Our best American Airlines deals on Harrisburg to South Carolina flight tickets

American Airlines

Nov 19

MDT9:39 amHarrisburg

5h 57m

1 stop

GSP3:36 pmGreenville

Nov 23

GSP8:35 pmGreenville

3h 38m

1 stop

MDT12:13 amHarrisburg

$319

American Airlines

Nov 20

MDT7:05 pmHarrisburg

4h 39m

1 stop

CHS11:44 pmCharleston

Nov 24

CHS5:05 amCharleston

4h 18m

1 stop

MDT9:23 amHarrisburg

$322

American Airlines

Oct 21

MDT12:18 pmHarrisburg

5h 36m

1 stop

CHS5:54 pmCharleston

Oct 24

CHS6:44 pmCharleston

4h 15m

1 stop

MDT10:59 pmHarrisburg

$339

momondo Fare Finder

Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

HarrisburgMyrtle Beach

MDT Harrisburg - MYR Myrtle Beach Intl

MDTMYR

Harrisburg

Sun 10/25

4:05 pm-5:35 pm

Nonstop1h 30m

Myrtle Beach Intl

Thu 10/29

6:25 pm-8:01 pm

Nonstop1h 36m

$125

HarrisburgMyrtle Beach

MDT Harrisburg - MYR Myrtle Beach Intl

MDTMYR

Harrisburg

Sun 10/18

3:58 pm-5:28 pm

Nonstop1h 30m

Myrtle Beach Intl

Thu 10/22

6:25 pm-8:01 pm

Nonstop1h 36m

$133

HarrisburgCharleston

MDT Harrisburg - CHS Charleston

MDTCHS

Harrisburg

Mon 11/2

7:32 pm-8:38 am

1 stop13h 06m

Charleston

Thu 11/5

9:39 pm-9:03 am

1 stop11h 24m

$287

HarrisburgMyrtle Beach

MDT Harrisburg - MYR Myrtle Beach Intl

MDTMYR

Harrisburg

Thu 10/22

8:51 pm-8:45 am

1 stop11h 54m

Myrtle Beach Intl

Thu 10/29

6:25 pm-8:01 pm

Nonstop1h 36m

$296

HarrisburgCharleston

MDT Harrisburg - CHS Charleston

MDTCHS

Harrisburg

Tue 11/10

2:38 pm-7:11 pm

1 stop4h 33m

Charleston

Sat 11/14

12:30 pm-6:57 pm

1 stop6h 27m

$305

HarrisburgCharleston

MDT Harrisburg - CHS Charleston

MDTCHS

Harrisburg

Tue 11/10

6:23 pm-11:59 pm

1 stop5h 36m

Charleston

Sat 11/14

5:49 pm-11:50 pm

1 stop6h 01m

$305

HarrisburgGreenville

MDT Harrisburg - GSP Greenville

MDTGSP

Harrisburg

Thu 11/19

9:39 am-3:36 pm

1 stop5h 57m

Greenville

Mon 11/23

8:35 pm-12:13 am

1 stop3h 38m

$319

HarrisburgGreenville

MDT Harrisburg - GSP Greenville

MDTGSP

Harrisburg

Sat 12/12

12:45 pm-7:09 pm

1 stop6h 24m

Greenville

Mon 12/14

7:40 pm-11:22 pm

1 stop3h 42m

$319

HarrisburgGreenville

MDT Harrisburg - GSP Greenville

MDTGSP

Harrisburg

Fri 12/4

6:33 pm-11:47 pm

1 stop5h 14m

Greenville

Mon 12/7

7:25 pm-11:48 pm

1 stop4h 23m

$319

HarrisburgCharleston

MDT Harrisburg - CHS Charleston

MDTCHS

Harrisburg

Fri 1/15

6:30 am-1:46 pm

1 stop7h 16m

Charleston

Tue 1/19

2:30 pm-6:28 pm

1 stop3h 58m

$368

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Harrisburg to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Harrisburg is in June. Flight prices, which tend to average around $199, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of June, then book flights to South Carolina from Harrisburg during April instead. Flights to South Carolina in April, while not as cheap as those in June, still average around $257.

What is the cheapest Harrisburg to South Carolina flight route?

Fly from Harrisburg to Myrtle Beach Intl for the best Harrisburg - South Carolina flight prices

What cabin class options are available on Harrisburg to South Carolina flights?

There is only 1 cabin class available to choose from on Harrisburg to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Harrisburg to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Harrisburg to South Carolina.

Cheap Harrisburg to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to South Carolina

Best Price Found	$49
Fastest flight time	1h 30m
Direct flights	Mon and Fri
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Harrisburg in the past 72 hours is $49. The best round-trip flight deal from Harrisburg to South Carolina found on momondo in the last 72 hours is $125.

The fastest flight from Harrisburg to South Carolina takes 1h 30m

Direct flights go from Harrisburg to South Carolina on Monday and Friday. There are no airlines offering direct flights.

There are 57 airports in South Carolina. From Harrisburg there are direct flights to Myrtle Beach Intl (MYR).

Search flight deals

Frequently asked questions about flying from Harrisburg to South Carolina

When did momondo last update prices for flights from Harrisburg Airport to South Carolina?
Prices for flights from Harrisburg Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Harrisburg Airport to South Carolina?
As of October 2026, there are 4 operators available to choose from for flights from Harrisburg Airport to South Carolina.
How old do you have to be to fly from Harrisburg Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Harrisburg Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Harrisburg to South Carolina?
Based on momondo bookings for flights between Harrisburg and South Carolina, the leading plane model is Airbus A320-100/200, making up 42.62% of the total bookings. Other popular models include Boeing 737 MAX 8 with 36.07%, Airbus A319 with 9.84%, and Airbus A321-100/200 with 1.64%.

Best airlines flying from Harrisburg to South Carolina

Compare and see reviews for airlines that fly from Harrisburg to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Allegiant Air	PriceFrom $122	Free Cancellation	Rating 7.3 678 reviews	Search Allegiant Air flights
United Airlines	PriceFrom $228	Free Cancellation	Rating 7.4 10,279 reviews	Search United Airlines flights
American Airlines	PriceFrom $254	Free Cancellation	Rating 7.0 12,128 reviews	Search American Airlines flights
Delta	PriceFrom $269	Free Cancellation	Rating 7.8 8,631 reviews	Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Harrisburg to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Harrisburg to South Carolina with flexible booking policies on momondo?

Flights from Harrisburg to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Harrisburg to South Carolina?

Once all potential Harrisburg to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Harrisburg to South Carolina right now. Can momondo alert me if prices change?

Price alerts on flights to South Carolina from Harrisburg are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.