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Cheap flights from Fort Myers to Knoxville from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Fort Myers to Knoxville (RSW-TYS)

Cheap round-trip flights

American Airlines Logo
5:23 pm - 10:54 pmRSW-TYS
5h 31m1 stop
American Airlines Logo
4:15 pm - 8:41 pmTYS-RSW
4h 26m1 stop
$249American Airlines
Find Deal
jue., nov. 20 - dom., nov. 23
American Airlines Logo
7:34 pm - 12:07 amRSW-TYS
4h 33m1 stop
American Airlines Logo
5:19 pm - 10:33 pmTYS-RSW
5h 14m1 stop
$254American Airlines
Find Deal
jue., sep. 18 - lun., sep. 22
American Airlines Logo
9:19 am - 2:39 pmRSW-TYS
5h 20m1 stop
American Airlines Logo
5:05 am - 10:24 amTYS-RSW
5h 19m1 stop
$259American Airlines
Find Deal
jue., sep. 4 - lun., sep. 8
Delta Logo
8:14 am - 2:43 pmRSW-TYS
6h 29m1 stop
Delta Logo
5:44 am - 10:08 amTYS-RSW
4h 24m1 stop
$313Delta
Find Deal
vie., oct. 17 - mié., oct. 22
United Airlines Logo
5:08 pm - 11:44 pmRSW-TYS
6h 36m1 stop
United Airlines Logo
5:45 am - 2:19 pmTYS-RSW
8h 34m2 stops
$324United Airlines
Find Deal
sáb., nov. 8 - mar., nov. 11
United Airlines Logo
12:42 pm - 8:33 pmRSW-TYS
7h 51m1 stop
United Airlines Logo
9:50 am - 11:38 pmTYS-RSW
13h 48m2 stops
$336United Airlines
Find Deal
jue., nov. 20 - lun., nov. 24
United Airlines Logo
5:08 pm - 11:44 pmRSW-TYS
6h 36m1 stop
United Airlines Logo
5:45 am - 5:53 pmTYS-RSW
12h 08m2 stops
$344United Airlines
Find Deal
mié., nov. 19 - dom., nov. 23
Delta Logo
1:00 pm - 6:13 pmRSW-TYS
5h 13m1 stop
Delta Logo
7:15 pm - 12:35 amTYS-RSW
5h 20m1 stop
$354Delta
Find Deal
jue., nov. 13 - dom., nov. 16
Logo
7:00 am - 10:21 pmRSW-TYS
15h 21m1 stop
Logo
9:00 am - 3:56 pmTYS-RSW
30h 56m2 stops
$382
Find Deal
vie., sep. 19 - lun., sep. 29
Logo
4:44 pm - 11:18 amRSW-TYS
18h 34m3 stops
Logo
4:31 pm - 11:51 amTYS-RSW
19h 20m3 stops
$393
Find Deal
mié., sep. 3 - mié., sep. 10

United Airlines flights from Fort Myers to Knoxville

Our best United Airlines deals on Fort Myers to Knoxville flight tickets
United Airlines
Nov 8
RSW5:08 pmFort Myers SW Florida Intl
6h 36m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Nov 11
TYS5:45 amKnoxville McGhee Tyson
8h 34m
2 stops
RSW2:19 pmFort Myers SW Florida Intl
$324
Find similar
United Airlines
Sep 4
RSW5:14 pmFort Myers SW Florida Intl
6h 30m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 6
TYS7:00 amKnoxville McGhee Tyson
11h 07m
2 stops
RSW6:07 pmFort Myers SW Florida Intl
$334
Find similar
United Airlines
Nov 20
RSW12:42 pmFort Myers SW Florida Intl
7h 51m
1 stop
TYS8:33 pmKnoxville McGhee Tyson
Nov 24
TYS9:50 amKnoxville McGhee Tyson
13h 48m
2 stops
RSW11:38 pmFort Myers SW Florida Intl
$336
Find similar

American Airlines flights from Fort Myers to Knoxville

Our best American Airlines deals on Fort Myers to Knoxville flight tickets
American Airlines
Nov 20
RSW5:23 pmFort Myers SW Florida Intl
5h 31m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Nov 23
TYS4:15 pmKnoxville McGhee Tyson
4h 26m
1 stop
RSW8:41 pmFort Myers SW Florida Intl
$249
Find similar
American Airlines
Sep 18
RSW7:34 pmFort Myers SW Florida Intl
4h 33m
1 stop
TYS12:07 amKnoxville McGhee Tyson
Sep 22
TYS5:19 pmKnoxville McGhee Tyson
5h 14m
1 stop
RSW10:33 pmFort Myers SW Florida Intl
$254
Find similar
American Airlines
Sep 4
RSW9:19 amFort Myers SW Florida Intl
5h 20m
1 stop
TYS2:39 pmKnoxville McGhee Tyson
Sep 8
TYS5:05 amKnoxville McGhee Tyson
5h 19m
1 stop
RSW10:24 amFort Myers SW Florida Intl
$259
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agosto 21, 2025.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 11/20

5:23 pm-10:54 pm

1 stop5h 31m

Knoxville McGhee Tyson

dom. 11/23

4:15 pm-8:41 pm

1 stop4h 26m

$249

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 9/18

7:34 pm-12:07 am

1 stop4h 33m

Knoxville McGhee Tyson

lun. 9/22

5:19 pm-10:33 pm

1 stop5h 14m

$254

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 9/4

9:19 am-2:39 pm

1 stop5h 20m

Knoxville McGhee Tyson

lun. 9/8

5:05 am-10:24 am

1 stop5h 19m

$259

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

vie. 10/17

8:14 am-2:43 pm

1 stop6h 29m

Knoxville McGhee Tyson

mié. 10/22

5:44 am-10:08 am

1 stop4h 24m

$313

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

sáb. 11/8

5:08 pm-11:44 pm

1 stop6h 36m

Knoxville McGhee Tyson

mar. 11/11

5:45 am-2:19 pm

2 stops8h 34m

$324

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 11/20

12:42 pm-8:33 pm

1 stop7h 51m

Knoxville McGhee Tyson

lun. 11/24

9:50 am-11:38 pm

2 stops13h 48m

$336

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

mié. 11/19

5:08 pm-11:44 pm

1 stop6h 36m

Knoxville McGhee Tyson

dom. 11/23

5:45 am-5:53 pm

2 stops12h 08m

$344

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 11/13

1:00 pm-6:13 pm

1 stop5h 13m

Knoxville McGhee Tyson

dom. 11/16

7:15 pm-12:35 am

1 stop5h 20m

$354

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

vie. 9/19

7:00 am-10:21 pm

1 stop15h 21m

Knoxville McGhee Tyson

lun. 9/29

9:00 am-3:56 pm

2 stops30h 56m

$382

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

mié. 9/3

4:44 pm-11:18 am

3 stops18h 34m

Knoxville McGhee Tyson

mié. 9/10

4:31 pm-11:51 am

3 stops19h 20m

$393

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $248. If you aren’t able to travel during the month of September, then book flights to Knoxville from Fort Myers during March instead. Flights to Knoxville in March, while not as cheap as those in September, still average around $253.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Fort Myers to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $273. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Fort Myers to Knoxville for around $368.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Fort Myers to Knoxville when you can find flight prices for as low as $282. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $466.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Fort Myers when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Fort Myers for as low as $212 on momondo.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Direct flights

None
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
Search flight deals

  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 4h 18m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $223Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

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