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Cheap flights from Fort Myers to Knoxville from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Fort Myers to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:40 am - 3:20 pm
RSW
-
TYS
6h 40m1 stop
American Airlines Logo
5:14 pm - 11:58 pm
TYS
-
RSW
6h 44m1 stop
$238American Airlines
sáb., ene. 10 - sáb., ene. 17
Delta Logo
5:35 am - 9:24 am
RSW
-
TYS
3h 49m1 stop
Delta Logo
5:40 am - 11:55 am
TYS
-
RSW
6h 15m1 stop
$279Delta
sáb., feb. 7 - dom., feb. 8
Southwest Logo
5:25 am - 11:50 am
RSW
-
TYS
6h 25m1 stop
Southwest Logo
1:20 pm - 9:55 pm
TYS
-
RSW
8h 35m1 stop
$284Southwest
mié., mar. 11 - lun., mar. 16
Southwest Logo
9:40 am - 8:05 pm
RSW
-
TYS
10h 25m2 stops
Southwest Logo
1:20 pm - 9:55 pm
TYS
-
RSW
8h 35m1 stop
$290Southwest
mié., mar. 11 - lun., mar. 16
American Airlines Logo
11:10 am - 4:49 pm
RSW
-
TYS
5h 39m1 stop
American Airlines Logo
4:00 pm - 7:59 pm
TYS
-
RSW
3h 59m1 stop
$299American Airlines
jue., ene. 22 - lun., ene. 26
Southwest Logo
7:15 am - 5:40 pm
RSW
-
TYS
10h 25m2 stops
Southwest Logo
1:20 pm - 11:20 pm
TYS
-
RSW
10h 00m2 stops
$308Southwest
mié., mar. 11 - lun., mar. 16
Delta Logo
7:56 pm - 11:46 pm
RSW
-
TYS
3h 50m1 stop
Delta Logo
7:20 pm - 11:02 pm
TYS
-
RSW
3h 42m1 stop
$319Delta
vie., may. 22 - lun., may. 25
Southwest Logo
9:00 am - 6:10 pm
RSW
-
TYS
9h 10m2 stops
Southwest Logo
6:35 am - 4:15 pm
TYS
-
RSW
9h 40m1 stop
$329Southwest
jue., may. 14 - lun., may. 18
Southwest Logo
12:55 pm - 9:15 pm
RSW
-
TYS
8h 20m2 stops
Southwest Logo
8:15 am - 3:40 pm
TYS
-
RSW
7h 25m1 stop
$343Southwest
lun., abr. 27 - mié., abr. 29
Southwest Logo
12:55 pm - 9:15 pm
RSW
-
TYS
8h 20m2 stops
Southwest Logo
7:05 am - 5:35 pm
TYS
-
RSW
10h 30m2 stops
$348Southwest
lun., abr. 27 - mié., abr. 29

Delta flights from Fort Myers to Knoxville

Our best Delta deals on Fort Myers to Knoxville flight tickets
Delta
Feb 7
RSW5:35 amFort Myers SW Florida Intl
3h 49m
1 stop
TYS9:24 amKnoxville McGhee Tyson
Feb 8
TYS5:40 amKnoxville McGhee Tyson
6h 15m
1 stop
RSW11:55 amFort Myers SW Florida Intl
$279
Find similar
Delta
May 22
RSW7:56 pmFort Myers SW Florida Intl
3h 50m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
May 25
TYS7:20 pmKnoxville McGhee Tyson
3h 42m
1 stop
RSW11:02 pmFort Myers SW Florida Intl
$319
Find similar
Delta
Jan 1
RSW5:35 amFort Myers SW Florida Intl
4h 56m
1 stop
TYS10:31 amKnoxville McGhee Tyson
Jan 4
TYS6:59 pmKnoxville McGhee Tyson
5h 39m
1 stop
RSW12:38 amFort Myers SW Florida Intl
$377
Find similar

United Airlines flights from Fort Myers to Knoxville

Our best United Airlines deals on Fort Myers to Knoxville flight tickets
United Airlines
Jan 16
RSW2:35 pmFort Myers SW Florida Intl
19h 57m
1 stop
TYS10:32 amKnoxville McGhee Tyson
Jan 19
TYS6:45 amKnoxville McGhee Tyson
28h 33m
1 stop
RSW11:18 amFort Myers SW Florida Intl
$495
Find similar
United Airlines
Feb 5
RSW9:20 amFort Myers SW Florida Intl
11h 32m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Feb 8
TYS6:45 amKnoxville McGhee Tyson
10h 07m
1 stop
RSW4:52 pmFort Myers SW Florida Intl
$515
Find similar
United Airlines
Jan 22
RSW5:55 pmFort Myers SW Florida Intl
26h 57m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Jan 26
TYS7:20 pmKnoxville McGhee Tyson
18h 31m
2 stops
RSW1:51 pmFort Myers SW Florida Intl
$517
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

sáb. 1/10

8:40 am-3:20 pm

1 stop6h 40m

Knoxville McGhee Tyson

sáb. 1/17

5:14 pm-11:58 pm

1 stop6h 44m

$238

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

sáb. 2/7

5:35 am-9:24 am

1 stop3h 49m

Knoxville McGhee Tyson

dom. 2/8

5:40 am-11:55 am

1 stop6h 15m

$279

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

mié. 3/11

5:25 am-11:50 am

1 stop6h 25m

Knoxville McGhee Tyson

lun. 3/16

1:20 pm-9:55 pm

1 stop8h 35m

$284

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

mié. 3/11

9:40 am-8:05 pm

2 stops10h 25m

Knoxville McGhee Tyson

lun. 3/16

1:20 pm-9:55 pm

1 stop8h 35m

$290

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 1/22

11:10 am-4:49 pm

1 stop5h 39m

Knoxville McGhee Tyson

lun. 1/26

4:00 pm-7:59 pm

1 stop3h 59m

$299

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

mié. 3/11

7:15 am-5:40 pm

2 stops10h 25m

Knoxville McGhee Tyson

lun. 3/16

1:20 pm-11:20 pm

2 stops10h 00m

$308

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

vie. 5/22

7:56 pm-11:46 pm

1 stop3h 50m

Knoxville McGhee Tyson

lun. 5/25

7:20 pm-11:02 pm

1 stop3h 42m

$319

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

jue. 5/14

9:00 am-6:10 pm

2 stops9h 10m

Knoxville McGhee Tyson

lun. 5/18

6:35 am-4:15 pm

1 stop9h 40m

$329

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

lun. 4/27

12:55 pm-9:15 pm

2 stops8h 20m

Knoxville McGhee Tyson

mié. 4/29

8:15 am-3:40 pm

1 stop7h 25m

$343

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

lun. 4/27

12:55 pm-9:15 pm

2 stops8h 20m

Knoxville McGhee Tyson

mié. 4/29

7:05 am-5:35 pm

2 stops10h 30m

$348

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $228. If you aren’t able to travel during the month of March, then book flights to Knoxville from Fort Myers during September instead. Flights to Knoxville in September, while not as cheap as those in March, still average around $268.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Fort Myers to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $273. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Fort Myers to Knoxville for around $368.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Fort Myers to Knoxville when you can find flight prices for as low as $282. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $466.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Fastest flight time

3h 46m

Direct flights

None
The fastest flight from Fort Myers to Knoxville takes 3h 46m
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
Search flight deals

  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 3h 46m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

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