Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Fort Myers to Knoxville from $143

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Fort Myers to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:07 am - 5:34 pm
RSW
-
TYS
6h 27m
1 stop
American Airlines Logo
7:00 am - 1:05 pm
TYS
-
RSW
6h 05m
1 stop
$292American Airlines
Tue, Sep 1 - Sun, Sep 6
American Airlines Logo
7:10 am - 11:44 am
RSW
-
TYS
4h 34m
1 stop
American Airlines Logo
7:00 am - 1:05 pm
TYS
-
RSW
6h 05m
1 stop
$299American Airlines
Tue, Sep 1 - Sun, Sep 6
American Airlines Logo
7:10 am - 11:44 am
RSW
-
TYS
4h 34m
1 stop
American Airlines Logo
7:00 am - 1:05 pm
TYS
-
RSW
6h 05m
1 stop
$302American Airlines
Tue, Sep 1 - Sun, Sep 6
American Airlines Logo
6:34 pm - 10:58 pm
RSW
-
TYS
4h 24m
1 stop
American Airlines Logo
7:00 am - 1:05 pm
TYS
-
RSW
6h 05m
1 stop
$305American Airlines
Mon, Aug 24 - Sat, Aug 29
American Airlines Logo
7:41 pm - 11:51 pm
RSW
-
TYS
4h 10m
1 stop
American Airlines Logo
6:07 pm - 10:53 pm
TYS
-
RSW
4h 46m
1 stop
$309American Airlines
Fri, Jul 3 - Mon, Jul 6
Southwest Logo
8:55 am - 7:55 pm
RSW
-
TYS
11h 00m
2 stops
Southwest Logo
6:50 am - 1:10 pm
TYS
-
RSW
6h 20m
1 stop
$310Southwest
Mon, Aug 24 - Sat, Aug 29
Southwest Logo
6:10 am - 12:05 pm
RSW
-
TYS
5h 55m
2 stops
Southwest Logo
7:30 am - 6:20 pm
TYS
-
RSW
10h 50m
1 stop
$313Southwest
Tue, Jul 7 - Thu, Jul 9
Delta Logo
6:50 am - 1:24 pm
RSW
-
TYS
6h 34m
1 stop
Delta Logo
5:30 am - 9:56 am
TYS
-
RSW
4h 26m
1 stop
$316Delta
Thu, Sep 3 - Tue, Sep 8
Southwest Logo
6:10 am - 12:05 pm
RSW
-
TYS
5h 55m
2 stops
Southwest Logo
6:40 am - 6:20 pm
TYS
-
RSW
11h 40m
2 stops
$318Southwest
Tue, Jul 7 - Thu, Jul 9
American Airlines Logo
7:41 pm - 11:51 pm
RSW
-
TYS
4h 10m
1 stop
American Airlines Logo
6:07 pm - 10:53 pm
TYS
-
RSW
4h 46m
1 stop
$319American Airlines
Thu, Jul 2 - Mon, Jul 6

American Airlines flights from Fort Myers to Knoxville

Our best American Airlines deals on Fort Myers to Knoxville flight tickets
American Airlines
Sep 1
RSW11:07 amFort Myers SW Florida Intl
6h 27m
1 stop
TYS5:34 pmKnoxville McGhee Tyson
Sep 6
TYS7:00 amKnoxville McGhee Tyson
6h 05m
1 stop
RSW1:05 pmFort Myers SW Florida Intl
$292
American Airlines
Sep 1
RSW7:10 amFort Myers SW Florida Intl
4h 34m
1 stop
TYS11:44 amKnoxville McGhee Tyson
Sep 6
TYS7:00 amKnoxville McGhee Tyson
6h 05m
1 stop
RSW1:05 pmFort Myers SW Florida Intl
$299
American Airlines
Sep 1
RSW7:10 amFort Myers SW Florida Intl
4h 34m
1 stop
TYS11:44 amKnoxville McGhee Tyson
Sep 6
TYS7:00 amKnoxville McGhee Tyson
6h 05m
1 stop
RSW1:05 pmFort Myers SW Florida Intl
$302

Southwest flights from Fort Myers to Knoxville

Our best Southwest deals on Fort Myers to Knoxville flight tickets
Southwest
Jul 1
RSW6:10 amFort Myers SW Florida Intl
10h 50m
1 stop
TYS5:00 pmKnoxville McGhee Tyson
Jul 15
TYS12:45 pmKnoxville McGhee Tyson
9h 20m
1 stop
RSW10:05 pmFort Myers SW Florida Intl
$293
Southwest
Aug 24
RSW8:55 amFort Myers SW Florida Intl
11h 00m
2 stops
TYS7:55 pmKnoxville McGhee Tyson
Aug 29
TYS6:50 amKnoxville McGhee Tyson
6h 20m
1 stop
RSW1:10 pmFort Myers SW Florida Intl
$310
Southwest
Jul 7
RSW6:10 amFort Myers SW Florida Intl
5h 55m
2 stops
TYS12:05 pmKnoxville McGhee Tyson
Jul 9
TYS7:30 amKnoxville McGhee Tyson
10h 50m
1 stop
RSW6:20 pmFort Myers SW Florida Intl
$313

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 22, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 9/1

11:07 am-5:34 pm

1 stop6h 27m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-1:05 pm

1 stop6h 05m

$292

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 9/1

7:10 am-11:44 am

1 stop4h 34m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-1:05 pm

1 stop6h 05m

$299

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 9/1

7:10 am-11:44 am

1 stop4h 34m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-1:05 pm

1 stop6h 05m

$302

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 8/24

6:34 pm-10:58 pm

1 stop4h 24m

Knoxville McGhee Tyson

Sat 8/29

7:00 am-1:05 pm

1 stop6h 05m

$305
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 7/3

7:41 pm-11:51 pm

1 stop4h 10m

Knoxville McGhee Tyson

Mon 7/6

6:07 pm-10:53 pm

1 stop4h 46m

$309

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 8/24

8:55 am-7:55 pm

2 stops11h 00m

Knoxville McGhee Tyson

Sat 8/29

6:50 am-1:10 pm

1 stop6h 20m

$310

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 7/7

6:10 am-12:05 pm

2 stops5h 55m

Knoxville McGhee Tyson

Thu 7/9

7:30 am-6:20 pm

1 stop10h 50m

$313

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 9/3

6:50 am-1:24 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 9/8

5:30 am-9:56 am

1 stop4h 26m

$316

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 7/7

6:10 am-12:05 pm

2 stops5h 55m

Knoxville McGhee Tyson

Thu 7/9

6:40 am-6:20 pm

2 stops11h 40m

$318

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 7/2

7:41 pm-11:51 pm

1 stop4h 10m

Knoxville McGhee Tyson

Mon 7/6

6:07 pm-10:53 pm

1 stop4h 46m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Fort Myers and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $319. If you aren’t able to travel during the month of September, then book flights to Knoxville from Fort Myers during February instead. Flights to Knoxville in February, while not as cheap as those in September, still average around $333.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Fastest flight time

3h 37m

Direct flights

None
The fastest flight from Fort Myers to Knoxville takes 3h 37m
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
Search flight deals

Frequently asked questions about flying from Fort Myers to Knoxville

  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 3h 37m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
8,449 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,644 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 6/21
Sun 6/28
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States