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Cheap flights from Fort Myers to Knoxville from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Fort Myers to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:24 pm - 10:25 pm
RSW
-
TYS
6h 01m
1 stop
American Airlines Logo
7:04 am - 2:12 pm
TYS
-
RSW
7h 08m
1 stop
$278American Airlines
จ., พ.ค. 11 - อ., พ.ค. 12
Delta Logo
8:00 am - 2:33 pm
RSW
-
TYS
6h 33m
1 stop
Delta Logo
7:33 pm - 12:27 am
TYS
-
RSW
4h 54m
1 stop
$281Delta
อ., พ.ค. 19 - อ., พ.ค. 19
American Airlines Logo
6:15 am - 10:36 am
RSW
-
TYS
4h 21m
1 stop
American Airlines Logo
5:03 am - 9:08 am
TYS
-
RSW
4h 05m
1 stop
$282American Airlines
อ., มิ.ย. 2 - อ., ส.ค. 4
Southwest Logo
10:15 am - 8:20 pm
RSW
-
TYS
10h 05m
2 stops
Southwest Logo
8:15 am - 3:40 pm
TYS
-
RSW
7h 25m
1 stop
$283Southwest
จ., พ.ค. 11 - อ., พ.ค. 12
Southwest Logo
12:55 pm - 9:15 pm
RSW
-
TYS
8h 20m
2 stops
Southwest Logo
8:15 am - 8:35 pm
TYS
-
RSW
12h 20m
2 stops
$288Southwest
จ., พ.ค. 11 - อ., พ.ค. 12
Southwest Logo
6:10 am - 5:00 pm
RSW
-
TYS
10h 50m
1 stop
Southwest Logo
8:10 am - 9:10 pm
TYS
-
RSW
13h 00m
2 stops
$293Southwest
พ., มิ.ย. 17 - พ., ก.ค. 8
Delta Logo
5:46 pm - 12:01 am
RSW
-
TYS
6h 15m
1 stop
Delta Logo
7:33 pm - 12:27 am
TYS
-
RSW
4h 54m
1 stop
$294Delta
ส., พ.ค. 23 - พ., พ.ค. 27
Southwest Logo
12:55 pm - 7:40 pm
RSW
-
TYS
6h 45m
1 stop
Southwest Logo
7:00 am - 5:00 pm
TYS
-
RSW
10h 00m
2 stops
$297Southwest
อ., มิ.ย. 2 - อ., ส.ค. 4
Southwest Logo
12:55 pm - 8:50 pm
RSW
-
TYS
7h 55m
2 stops
Southwest Logo
8:00 am - 7:50 pm
TYS
-
RSW
11h 50m
2 stops
$302Southwest
อ., มิ.ย. 2 - อ., ส.ค. 4
American Airlines Logo
7:41 pm - 11:55 pm
RSW
-
TYS
4h 14m
1 stop
American Airlines Logo
3:58 pm - 8:55 pm
TYS
-
RSW
4h 57m
1 stop
$305American Airlines
จ., พ.ค. 4 - ศ., พ.ค. 8

Southwest flights from Fort Myers to Knoxville

Our best Southwest deals on Fort Myers to Knoxville flight tickets
Southwest
May 11
RSW10:15 amFort Myers SW Florida Intl
10h 05m
2 stops
TYS8:20 pmKnoxville McGhee Tyson
May 12
TYS8:15 amKnoxville McGhee Tyson
7h 25m
1 stop
RSW3:40 pmFort Myers SW Florida Intl
$283
Southwest
May 11
RSW12:55 pmFort Myers SW Florida Intl
8h 20m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
May 12
TYS8:15 amKnoxville McGhee Tyson
12h 20m
2 stops
RSW8:35 pmFort Myers SW Florida Intl
$288
Southwest
Jun 17
RSW6:10 amFort Myers SW Florida Intl
10h 50m
1 stop
TYS5:00 pmKnoxville McGhee Tyson
Jul 8
TYS8:10 amKnoxville McGhee Tyson
13h 00m
2 stops
RSW9:10 pmFort Myers SW Florida Intl
$293

Delta flights from Fort Myers to Knoxville

Our best Delta deals on Fort Myers to Knoxville flight tickets
Delta
May 19
RSW8:00 amFort Myers SW Florida Intl
6h 33m
1 stop
TYS2:33 pmKnoxville McGhee Tyson
May 19
TYS7:33 pmKnoxville McGhee Tyson
4h 54m
1 stop
RSW12:27 amFort Myers SW Florida Intl
$281
Delta
May 23
RSW5:46 pmFort Myers SW Florida Intl
6h 15m
1 stop
TYS12:01 amKnoxville McGhee Tyson
May 27
TYS7:33 pmKnoxville McGhee Tyson
4h 54m
1 stop
RSW12:27 amFort Myers SW Florida Intl
$294
Delta
May 23
RSW5:35 amFort Myers SW Florida Intl
3h 59m
1 stop
TYS9:34 amKnoxville McGhee Tyson
May 27
TYS1:59 pmKnoxville McGhee Tyson
4h 56m
1 stop
RSW6:55 pmFort Myers SW Florida Intl
$311

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated เมษายน 5, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

จ. 5/11

4:24 pm-10:25 pm

1 stop6h 01m

Knoxville McGhee Tyson

อ. 5/12

7:04 am-2:12 pm

1 stop7h 08m

$278

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

อ. 5/19

8:00 am-2:33 pm

1 stop6h 33m

Knoxville McGhee Tyson

อ. 5/19

7:33 pm-12:27 am

1 stop4h 54m

$281
Quickest round-trip

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

อ. 6/2

6:15 am-10:36 am

1 stop4h 21m

Knoxville McGhee Tyson

อ. 8/4

5:03 am-9:08 am

1 stop4h 05m

$282

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

จ. 5/11

10:15 am-8:20 pm

2 stops10h 05m

Knoxville McGhee Tyson

อ. 5/12

8:15 am-3:40 pm

1 stop7h 25m

$283

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

จ. 5/11

12:55 pm-9:15 pm

2 stops8h 20m

Knoxville McGhee Tyson

อ. 5/12

8:15 am-8:35 pm

2 stops12h 20m

$288

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

พ. 6/17

6:10 am-5:00 pm

1 stop10h 50m

Knoxville McGhee Tyson

พ. 7/8

8:10 am-9:10 pm

2 stops13h 00m

$293

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

ส. 5/23

5:46 pm-12:01 am

1 stop6h 15m

Knoxville McGhee Tyson

พ. 5/27

7:33 pm-12:27 am

1 stop4h 54m

$294

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

อ. 6/2

12:55 pm-7:40 pm

1 stop6h 45m

Knoxville McGhee Tyson

อ. 8/4

7:00 am-5:00 pm

2 stops10h 00m

$297

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

อ. 6/2

12:55 pm-8:50 pm

2 stops7h 55m

Knoxville McGhee Tyson

อ. 8/4

8:00 am-7:50 pm

2 stops11h 50m

$302

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

จ. 5/4

7:41 pm-11:55 pm

1 stop4h 14m

Knoxville McGhee Tyson

ศ. 5/8

3:58 pm-8:55 pm

1 stop4h 57m

$305

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Fort Myers and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $319. If you aren’t able to travel during the month of September, then book flights to Knoxville from Fort Myers during May instead. Flights to Knoxville in May, while not as cheap as those in September, still average around $328.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Fastest flight time

3h 58m

Direct flights

None
The fastest flight from Fort Myers to Knoxville takes 3h 58m
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
Search flight deals

Frequently asked questions about flying from Fort Myers to Knoxville

  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 3h 58m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,555 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,386 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

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1 adult
อ. 5/5
อ. 5/12
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