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Cheap flights from Fort Myers to Knoxville from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 3/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Fort Myers to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
1:00 pm - 7:40 pm
RSW
-
TYS
6h 40m
1 stop
Southwest Logo
6:40 am - 4:15 pm
TYS
-
RSW
9h 35m
1 stop
$259Southwest
Wed, Apr 22 - Sat, Apr 25
Southwest Logo
1:00 pm - 7:40 pm
RSW
-
TYS
6h 40m
1 stop
Southwest Logo
6:40 am - 6:45 pm
TYS
-
RSW
12h 05m
2 stops
$265Southwest
Wed, Apr 22 - Sat, Apr 25
Southwest Logo
6:45 am - 5:10 pm
RSW
-
TYS
10h 25m
2 stops
Southwest Logo
6:40 am - 6:45 pm
TYS
-
RSW
12h 05m
2 stops
$275Southwest
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
7:39 pm - 11:49 pm
RSW
-
TYS
4h 10m
1 stop
American Airlines Logo
3:40 pm - 10:42 pm
TYS
-
RSW
7h 02m
1 stop
$279American Airlines
Sat, May 23 - Wed, May 27
Delta Logo
5:50 am - 9:27 am
RSW
-
TYS
3h 37m
1 stop
Delta Logo
7:32 pm - 12:27 am
TYS
-
RSW
4h 55m
1 stop
$299Delta
Fri, May 29 - Mon, Jun 1
Multiple Airlines Logo
5:24 pm - 3:28 pm
RSW
-
TYS
22h 04m
1 stop
Multiple Airlines Logo
6:00 am - 6:19 pm
TYS
-
RSW
12h 19m
1 stop
$313Multiple Airlines
Thu, Apr 9 - Sun, Apr 12
Delta Logo
8:00 am - 2:33 pm
RSW
-
TYS
6h 33m
1 stop
Delta Logo
7:32 pm - 12:27 am
TYS
-
RSW
4h 55m
1 stop
$319Delta
Thu, May 28 - Mon, Jun 1
Southwest Logo
9:00 am - 6:10 pm
RSW
-
TYS
9h 10m
2 stops
Southwest Logo
12:15 pm - 9:45 pm
TYS
-
RSW
9h 30m
1 stop
$329Southwest
Thu, May 28 - Mon, Jun 1
Multiple Airlines Logo
7:36 pm - 12:25 pm
RSW
-
TYS
16h 49m
2 stops
Multiple Airlines Logo
6:00 am - 6:19 pm
TYS
-
RSW
12h 19m
1 stop
$330Multiple Airlines
Thu, Apr 9 - Sun, Apr 12
American Airlines Logo
6:00 am - 11:20 am
RSW
-
TYS
5h 20m
1 stop
American Airlines Logo
5:00 am - 9:30 am
TYS
-
RSW
4h 30m
1 stop
$338American Airlines
Thu, Mar 5 - Thu, Mar 12

Delta flights from Fort Myers to Knoxville

Our best Delta deals on Fort Myers to Knoxville flight tickets
Delta
May 29
RSW5:50 amFort Myers SW Florida Intl
3h 37m
1 stop
TYS9:27 amKnoxville McGhee Tyson
Jun 1
TYS7:32 pmKnoxville McGhee Tyson
4h 55m
1 stop
RSW12:27 amFort Myers SW Florida Intl
$299
Delta
May 28
RSW5:50 amFort Myers SW Florida Intl
5h 22m
1 stop
TYS11:12 amKnoxville McGhee Tyson
Jun 1
TYS7:32 pmKnoxville McGhee Tyson
4h 55m
1 stop
RSW12:27 amFort Myers SW Florida Intl
$319
Delta
Jun 12
RSW7:56 pmFort Myers SW Florida Intl
3h 50m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Jun 14
TYS5:30 amKnoxville McGhee Tyson
4h 28m
1 stop
RSW9:58 amFort Myers SW Florida Intl
$339

American Airlines flights from Fort Myers to Knoxville

Our best American Airlines deals on Fort Myers to Knoxville flight tickets
American Airlines
May 23
RSW7:39 pmFort Myers SW Florida Intl
4h 10m
1 stop
TYS11:49 pmKnoxville McGhee Tyson
May 27
TYS3:40 pmKnoxville McGhee Tyson
7h 02m
1 stop
RSW10:42 pmFort Myers SW Florida Intl
$279
American Airlines
Mar 5
RSW6:00 amFort Myers SW Florida Intl
5h 20m
1 stop
TYS11:20 amKnoxville McGhee Tyson
Mar 12
TYS5:00 amKnoxville McGhee Tyson
4h 30m
1 stop
RSW9:30 amFort Myers SW Florida Intl
$338
American Airlines
Apr 17
RSW7:41 pmFort Myers SW Florida Intl
4h 14m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Apr 20
TYS5:00 amKnoxville McGhee Tyson
4h 36m
1 stop
RSW9:36 amFort Myers SW Florida Intl
$401

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 4/22

1:00 pm-7:40 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-4:15 pm

1 stop9h 35m

$259

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 4/22

1:00 pm-7:40 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-6:45 pm

2 stops12h 05m

$265

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 4/22

6:45 am-5:10 pm

2 stops10h 25m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-6:45 pm

2 stops12h 05m

$275

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 5/23

7:39 pm-11:49 pm

1 stop4h 10m

Knoxville McGhee Tyson

Wed 5/27

3:40 pm-10:42 pm

1 stop7h 02m

$279

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 5/29

5:50 am-9:27 am

1 stop3h 37m

Knoxville McGhee Tyson

Mon 6/1

7:32 pm-12:27 am

1 stop4h 55m

$299

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 4/9

5:24 pm-3:28 pm

1 stop22h 04m

Knoxville McGhee Tyson

Sun 4/12

6:00 am-6:19 pm

1 stop12h 19m

$313

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 5/28

8:00 am-2:33 pm

1 stop6h 33m

Knoxville McGhee Tyson

Mon 6/1

7:32 pm-12:27 am

1 stop4h 55m

$319

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 5/28

9:00 am-6:10 pm

2 stops9h 10m

Knoxville McGhee Tyson

Mon 6/1

12:15 pm-9:45 pm

1 stop9h 30m

$329

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 4/9

7:36 pm-12:25 pm

2 stops16h 49m

Knoxville McGhee Tyson

Sun 4/12

6:00 am-6:19 pm

1 stop12h 19m

$330

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 3/5

6:00 am-11:20 am

1 stop5h 20m

Knoxville McGhee Tyson

Thu 3/12

5:00 am-9:30 am

1 stop4h 30m

$338

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $228. If you aren’t able to travel during the month of March, then book flights to Knoxville from Fort Myers during September instead. Flights to Knoxville in September, while not as cheap as those in March, still average around $288.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Fastest flight time

3h 29m

Direct flights

None
The fastest flight from Fort Myers to Knoxville takes 3h 29m
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
Search flight deals

  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 3h 29m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,237 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,151 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

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