Cheap flights from Fort Myers to Knoxville from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 11/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:35 am - 9:13 amRSW-TYS
3h 38m1 stop
Delta Logo
10:05 am - 1:57 pmTYS-RSW
3h 52m1 stop
$248Delta
Find Deal
Wed, Feb 18 - Sat, Feb 21
Delta Logo
5:35 am - 11:07 amRSW-TYS
5h 32m1 stop
Delta Logo
10:05 am - 3:41 pmTYS-RSW
5h 36m1 stop
$259Delta
Find Deal
Tue, Feb 10 - Tue, Feb 17
American Airlines Logo
8:34 am - 2:00 pmRSW-TYS
5h 26m1 stop
American Airlines Logo
7:23 pm - 11:29 pmTYS-RSW
4h 06m1 stop
$261American Airlines
Find Deal
Fri, Dec 12 - Mon, Dec 15
Delta Logo
7:49 pm - 11:41 pmRSW-TYS
3h 52m1 stop
Delta Logo
6:05 pm - 9:35 pmTYS-RSW
3h 30m1 stop
$269Delta
Find Deal
Mon, Nov 24 - Thu, Nov 27
Delta Logo
5:35 am - 9:13 amRSW-TYS
3h 38m1 stop
Delta Logo
10:05 am - 3:41 pmTYS-RSW
5h 36m1 stop
$279Delta
Find Deal
Thu, Feb 12 - Wed, Feb 18
American Airlines Logo
8:05 am - 2:19 pmRSW-TYS
6h 14m1 stop
American Airlines Logo
7:20 pm - 11:29 pmTYS-RSW
4h 09m1 stop
$329American Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
Multiple Airlines Logo
5:12 pm - 11:53 amRSW-TYS
18h 41m2 stops
Multiple Airlines Logo
10:15 am - 7:23 pmTYS-RSW
9h 08m2 stops
$349Multiple Airlines
Find Deal
Wed, Dec 3 - Sat, Dec 6
Multiple Airlines Logo
3:23 pm - 11:48 amRSW-TYS
20h 25m2 stops
Multiple Airlines Logo
11:24 am - 2:18 pmTYS-RSW
26h 54m3 stops
$351Multiple Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
United Airlines Logo
12:30 pm - 9:02 pmRSW-TYS
8h 32m1 stop
United Airlines Logo
6:45 am - 6:02 pmTYS-RSW
11h 17m2 stops
$374United Airlines
Find Deal
Fri, Jan 23 - Sun, Jan 25
United Airlines Logo
9:00 am - 9:02 pmRSW-TYS
12h 02m2 stops
United Airlines Logo
6:45 am - 6:02 pmTYS-RSW
11h 17m2 stops
$379United Airlines
Find Deal
Fri, Jan 23 - Sun, Jan 25

United Airlines flights from Fort Myers to Knoxville

Our best United Airlines deals on Fort Myers to Knoxville flight tickets
United Airlines
Jan 23
RSW12:30 pmFort Myers SW Florida Intl
8h 32m
1 stop
TYS9:02 pmKnoxville McGhee Tyson
Jan 25
TYS6:45 amKnoxville McGhee Tyson
11h 17m
2 stops
RSW6:02 pmFort Myers SW Florida Intl
United Airlines
Jan 23
RSW9:00 amFort Myers SW Florida Intl
12h 02m
2 stops
TYS9:02 pmKnoxville McGhee Tyson
Jan 25
TYS6:45 amKnoxville McGhee Tyson
11h 17m
2 stops
RSW6:02 pmFort Myers SW Florida Intl
United Airlines
Oct 31
RSW6:40 pmFort Myers SW Florida Intl
18h 37m
2 stops
TYS1:17 pmKnoxville McGhee Tyson
Nov 4
TYS9:50 amKnoxville McGhee Tyson
6h 10m
1 stop
RSW4:00 pmFort Myers SW Florida Intl

Delta flights from Fort Myers to Knoxville

Our best Delta deals on Fort Myers to Knoxville flight tickets
Delta
Feb 18
RSW5:35 amFort Myers SW Florida Intl
3h 38m
1 stop
TYS9:13 amKnoxville McGhee Tyson
Feb 21
TYS10:05 amKnoxville McGhee Tyson
3h 52m
1 stop
RSW1:57 pmFort Myers SW Florida Intl
Delta
Feb 10
RSW5:35 amFort Myers SW Florida Intl
5h 32m
1 stop
TYS11:07 amKnoxville McGhee Tyson
Feb 17
TYS10:05 amKnoxville McGhee Tyson
5h 36m
1 stop
RSW3:41 pmFort Myers SW Florida Intl
Delta
Nov 24
RSW7:49 pmFort Myers SW Florida Intl
3h 52m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
Nov 27
TYS6:05 pmKnoxville McGhee Tyson
3h 30m
1 stop
RSW9:35 pmFort Myers SW Florida Intl

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 21, 2025.
Use the filters below to find and compare flights from Fort Myers to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 2/18

5:35 am-9:13 am

1 stop3h 38m

Knoxville McGhee Tyson

Sat 2/21

10:05 am-1:57 pm

1 stop3h 52m

$248

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Tue 2/10

5:35 am-11:07 am

1 stop5h 32m

Knoxville McGhee Tyson

Tue 2/17

10:05 am-3:41 pm

1 stop5h 36m

$259

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 12/12

8:34 am-2:00 pm

1 stop5h 26m

Knoxville McGhee Tyson

Mon 12/15

7:23 pm-11:29 pm

1 stop4h 06m

$261

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Mon 11/24

7:49 pm-11:41 pm

1 stop3h 52m

Knoxville McGhee Tyson

Thu 11/27

6:05 pm-9:35 pm

1 stop3h 30m

$269

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Thu 2/12

5:35 am-9:13 am

1 stop3h 38m

Knoxville McGhee Tyson

Wed 2/18

10:05 am-3:41 pm

1 stop5h 36m

$279

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 11/8

8:05 am-2:19 pm

1 stop6h 14m

Knoxville McGhee Tyson

Tue 11/11

7:20 pm-11:29 pm

1 stop4h 09m

$329

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Wed 12/3

5:12 pm-11:53 am

2 stops18h 41m

Knoxville McGhee Tyson

Sat 12/6

10:15 am-7:23 pm

2 stops9h 08m

$349

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Sat 11/8

3:23 pm-11:48 am

2 stops20h 25m

Knoxville McGhee Tyson

Tue 11/11

11:24 am-2:18 pm

3 stops26h 54m

$351

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 1/23

12:30 pm-9:02 pm

1 stop8h 32m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-6:02 pm

2 stops11h 17m

$374

Fort MyersKnoxville

RSW - TYS

RSWTYS

Fort Myers SW Florida Intl

Fri 1/23

9:00 am-9:02 pm

2 stops12h 02m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-6:02 pm

2 stops11h 17m

$379

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Fort Myers to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Fort Myers, with most prices found around $253. If you aren’t able to travel during the month of March, then book flights to Knoxville from Fort Myers during September instead. Flights to Knoxville in September, while not as cheap as those in March, still average around $268.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Fort Myers to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $273. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Fort Myers to Knoxville for around $368.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Fort Myers to Knoxville when you can find flight prices for as low as $282. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $466.

How have Fort Myers to Knoxville flight prices changed over time?

When to book flights from Fort Myers to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Knoxville (RSW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Knoxville

Direct flights

None
There are no direct flights from Fort Myers to Knoxville. There are no popular flight routes from Fort Myers to Knoxville.
  • How far is Fort Myers SW Florida Intl to Knoxville McGhee Tyson by plane?

    Fort Myers SW Florida Intl and Knoxville McGhee Tyson are 654.7 mi apart from one another. In terms of flight time, this usually takes a little over 3h 38m.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Fort Myers to Knoxville?

Best airlines flying from Fort Myers to Knoxville

Compare and see reviews for airlines that fly from Fort Myers to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,023 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
7,978 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Knoxville for you.

Can I find flights from Fort Myers to Knoxville with flexible booking policies on momondo?

Flights from Fort Myers to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Fort Myers to Knoxville?

momondo helps you find the best flight between Fort Myers and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Fort Myers to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Fort Myers and alert you when they change.

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1 adult
Thu 11/20
Thu 11/27

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