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Cheap flights from Detroit to Greenville from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to Greenville departing on 9/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
4:55 pm - 1:07 pm
GSP
-
DTW
20h 12m
1 stop
$211Multiple Airlines
Wed, Aug 19 - Mon, Aug 24
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
12:06 pm - 1:07 pm
GSP
-
DTW
25h 01m
1 stop
$226Multiple Airlines
Wed, Aug 19 - Mon, Aug 24
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
12:06 pm - 1:07 pm
GSP
-
DTW
25h 01m
1 stop
$232Multiple Airlines
Wed, Sep 2 - Mon, Sep 7
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
8:13 pm - 1:07 pm
GSP
-
DTW
16h 54m
2 stops
$239Multiple Airlines
Wed, Aug 19 - Mon, Aug 24
Multiple Airlines Logo
9:12 am - 7:33 pm
DTW
-
GSP
10h 21m
2 stops
Multiple Airlines Logo
3:35 pm - 12:55 pm
GSP
-
DTW
21h 20m
1 stop
$242Multiple Airlines
Fri, Jul 31 - Sun, Aug 2
Multiple Airlines Logo
11:00 am - 2:56 pm
DTW
-
GSP
27h 56m
1 stop
Multiple Airlines Logo
3:18 pm - 1:07 pm
GSP
-
DTW
21h 49m
1 stop
$243Multiple Airlines
Thu, Sep 3 - Mon, Sep 7
Multiple Airlines Logo
9:12 am - 5:39 pm
DTW
-
GSP
8h 27m
1 stop
Multiple Airlines Logo
3:35 pm - 12:55 pm
GSP
-
DTW
21h 20m
1 stop
$248Multiple Airlines
Fri, Jul 31 - Sun, Aug 2
Multiple Airlines Logo
11:00 am - 6:30 pm
DTW
-
GSP
7h 30m
1 stop
Multiple Airlines Logo
7:03 pm - 1:07 pm
GSP
-
DTW
18h 04m
2 stops
$256Multiple Airlines
Mon, Sep 21 - Mon, Sep 28
Multiple Airlines Logo
10:08 am - 5:39 pm
DTW
-
GSP
7h 31m
1 stop
Multiple Airlines Logo
8:37 am - 12:55 pm
GSP
-
DTW
28h 18m
1 stop
$259Multiple Airlines
Mon, Aug 10 - Thu, Aug 13
Multiple Airlines Logo
11:00 am - 9:27 am
DTW
-
GSP
22h 27m
2 stops
Multiple Airlines Logo
12:11 pm - 1:07 pm
GSP
-
DTW
24h 56m
1 stop
$260Multiple Airlines
Wed, Sep 16 - Mon, Sep 21

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Southwest flights from Detroit to Greenville

Our best Southwest deals on Detroit to Greenville flight tickets
Southwest
Aug 4
DTW6:25 amDetroit Metropolitan Wayne County
10h 20m
2 stops
GSP4:45 pmGreenville
Aug 18
GSP8:15 amGreenville
4h 05m
1 stop
DTW12:20 pmDetroit Metropolitan Wayne County
$277
Southwest
Aug 5
DTW6:00 amDetroit Metropolitan Wayne County
6h 25m
1 stop
GSP12:25 pmGreenville
Aug 10
GSP1:05 pmGreenville
5h 30m
1 stop
DTW6:35 pmDetroit Metropolitan Wayne County
$299
Southwest
Aug 11
DTW2:45 pmDetroit Metropolitan Wayne County
4h 40m
1 stop
GSP7:25 pmGreenville
Aug 15
GSP6:45 amGreenville
7h 15m
1 stop
DTW2:00 pmDetroit Metropolitan Wayne County
$305

Delta flights from Detroit to Greenville

Our best Delta deals on Detroit to Greenville flight tickets
Delta
Jun 15
DTW8:05 pmDetroit Metropolitan Wayne County
1h 43m
GSP9:48 pmGreenville
Jun 30
GSP7:10 amGreenville
1h 50m
DTW9:00 amDetroit Metropolitan Wayne County
$549
Delta
Jun 15
DTW6:59 pmDetroit Metropolitan Wayne County
5h 00m
1 stop
GSP11:59 pmGreenville
Jun 30
GSP7:10 amGreenville
1h 50m
DTW9:00 amDetroit Metropolitan Wayne County
$559
Delta
Jun 16
DTW9:25 amDetroit Metropolitan Wayne County
4h 48m
1 stop
GSP2:13 pmGreenville
Jun 30
GSP5:16 pmGreenville
6h 42m
1 stop
DTW11:58 pmDetroit Metropolitan Wayne County
$569

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Detroit to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 8/19

11:00 am-7:57 am

1 stop20h 57m

Greenville

Mon 8/24

4:55 pm-1:07 pm

1 stop20h 12m

$211

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 8/19

11:00 am-7:57 am

1 stop20h 57m

Greenville

Mon 8/24

12:06 pm-1:07 pm

1 stop25h 01m

$226

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 9/2

11:00 am-7:57 am

1 stop20h 57m

Greenville

Mon 9/7

12:06 pm-1:07 pm

1 stop25h 01m

$232

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 8/19

11:00 am-7:57 am

1 stop20h 57m

Greenville

Mon 8/24

8:13 pm-1:07 pm

2 stops16h 54m

$239

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 7/31

9:12 am-7:33 pm

2 stops10h 21m

Greenville

Sun 8/2

3:35 pm-12:55 pm

1 stop21h 20m

$242

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 9/3

11:00 am-2:56 pm

1 stop27h 56m

Greenville

Mon 9/7

3:18 pm-1:07 pm

1 stop21h 49m

$243

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 7/31

9:12 am-5:39 pm

1 stop8h 27m

Greenville

Sun 8/2

3:35 pm-12:55 pm

1 stop21h 20m

$248
Quickest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 9/21

11:00 am-6:30 pm

1 stop7h 30m

Greenville

Mon 9/28

7:03 pm-1:07 pm

2 stops18h 04m

$256

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 8/10

10:08 am-5:39 pm

1 stop7h 31m

Greenville

Thu 8/13

8:37 am-12:55 pm

1 stop28h 18m

$259

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 9/16

11:00 am-9:27 am

2 stops22h 27m

Greenville

Mon 9/21

12:11 pm-1:07 pm

1 stop24h 56m

$260

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and Greenville?

What is the cheapest month to fly to Greenville?

The month of May is another great option to travel to Greenville, with average flight prices from Detroit averaging around $266.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Detroit. The lowest ticket price found for a Saturday departure recently was $469. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $693. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit to Greenville during this time can be as low as $489. Flights to Greenville are more costly in the evening, with an average ticket price of $569. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit - Greenville flight prices

What cabin class options are available on Detroit to Greenville flights?

There are 4 cabin classes available to choose from on Detroit to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to Greenville flights?

You could potentially save up to 31% on your flight if you consider stops on a Detroit to Greenville flight.

When to book flights from Detroit to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to Greenville (DTT to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to Greenville

Best Price Found

$333

Fastest flight time

1h 41m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sat

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit in the past 72 hours is $333. The best round-trip flight deal from Detroit to Greenville found on momondo in the last 72 hours is $509.
The fastest flight from Detroit to Greenville takes 1h 41m
Direct flights go from Detroit to Greenville on Monday, Tuesday, Wednesday, Thursday, Friday and Saturday. The only airline offering direct flights is Delta.
There is 1 airport in Greenville. From Detroit there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Detroit to Greenville

  • How far is Detroit to Greenville by plane?

    There are 518.0 mi between Detroit and Greenville. By plane, this route typically takes 1h 41m.

  • When did momondo last update prices for flights from Detroit to Greenville Airport?

    Prices for flights from Detroit to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Detroit to Greenville Airport?

  • How old do you have to be to fly from Detroit to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Detroit to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Detroit to Greenville?

  • What is the most popular airline from Detroit to Greenville?

Best airlines flying from Detroit to Greenville

Compare and see reviews for airlines that fly from Detroit to Greenville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $293Free CancellationRating
7.9
4,234 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,399 reviews
Search Delta flights

  • Delta Flights From Detroit to Greenville

    The lowest priced Delta flight from Detroit to Greenville from the last 72 hours was $399. Generally, Delta has 17 flights on this route every week with an average price of $559. Delta is rated 7.9/10 by our users.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Flights from Detroit to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to Greenville?

Once you have performed a search for Detroit to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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