Cheap flights from Detroit to Greenville from $119

The month of August is another great option to travel to Greenville, with average flight prices from Detroit averaging around $415.

According to our data, Wednesday is the cheapest day to fly to Greenville from Detroit. The lowest ticket price found for a Wednesday departure recently was $449. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $779. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit to Greenville during this time can be as low as $449. Flights to Greenville are more costly in the afternoon, with an average ticket price of $548. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit - Greenville flight prices

There are 3 cabin classes available to choose from on Detroit to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 33% on your flight if you consider stops on a Detroit to Greenville flight.

United Airlines, American Airlines, and Southwest are the most popular carriers operating from Detroit to Greenville

Delta, American Airlines and Frontier are the top three most popular airlines that fly to Greenville from Detroit according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 6 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

As of November 2026, 1 flights take off from Detroit and land in Greenville each day. The most common flight departure time for this route is 4:00PM, with 37% of daily flights taking off in the afternoon.

The number of flights available between Detroit and Greenville is 10 per week as of November 2026. The most frequent departure day is Fri, with 100% of weekly flights leaving on this day.