Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis from $78

In general, September is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $307. The month of November is another great option to travel to St. Louis, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $341.

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $386. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $484. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Detroit Metropolitan Wayne County Airport at noon is the least expensive time of day to depart. momondo users have found prices as low as $347 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $450 per ticket.

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit Metropolitan Wayne County - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit Metropolitan Wayne County Airport for as low as $279 on momondo.

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County Airport to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 22% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to St. Louis flight.

As of September 2026, prices for Detroit Metropolitan Wayne County Airport to St. Louis flights are approximately 20% more expensive when compared to flights at the same time last year.

Delta and Southwest are the most popular carriers operating from Detroit Metropolitan Wayne County to Lambert-St Louis

Delta, Southwest and Frontier are the top three most popular airlines that fly to St. Louis from Detroit Metropolitan Wayne County Airport according to our data. Delta is the first choice among our users, with 57% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

As of September 2026, 13 flights take off from Detroit Metropolitan Wayne County Airport and land in St. Louis each day. The most common flight departure time for this route is 7:00PM, with 48% of daily flights taking off in the afternoon.

As of September 2026, there are 97 flights per week flying from Detroit Metropolitan Wayne County Airport to St. Louis. The most common day of the week flights depart is Sun, with 18% of flights taking off on this day.