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Cheap flights from Detroit Metropolitan Wayne County Airport to St. Louis from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to St. Louis departing on 2/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:07 pm - 7:50 am
DTW
-
STL
16h 43m1 stop
Frontier Logo
8:36 pm - 11:52 am
STL
-
DTW
14h 16m1 stop
$154Frontier
Sat, Feb 21 - Sun, Feb 22
Multiple Airlines Logo
4:43 pm - 10:02 am
DTW
-
STL
18h 19m1 stop
Multiple Airlines Logo
5:11 pm - 1:52 pm
STL
-
DTW
19h 41m1 stop
$155Multiple Airlines
Thu, Jan 8 - Mon, Jan 12
Frontier Logo
6:07 pm - 7:50 am
DTW
-
STL
14h 43m1 stop
Frontier Logo
8:36 pm - 11:52 am
STL
-
DTW
14h 16m1 stop
$157Frontier
Thu, Feb 19 - Sun, Feb 22
Frontier Logo
4:43 pm - 10:02 am
DTW
-
STL
18h 19m1 stop
Frontier Logo
7:43 pm - 9:56 pm
STL
-
DTW
25h 13m2 stops
$164Frontier
Thu, Jan 8 - Mon, Jan 12
Multiple Airlines Logo
6:13 pm - 2:48 pm
DTW
-
STL
21h 35m1 stop
Multiple Airlines Logo
5:11 pm - 1:52 pm
STL
-
DTW
19h 41m1 stop
$168Multiple Airlines
Thu, Jan 8 - Mon, Jan 12
American Airlines Logo
9:40 am - 4:23 pm
DTW
-
STL
7h 43m1 stop
American Airlines Logo
6:00 am - 5:25 pm
STL
-
DTW
10h 25m1 stop
$177American Airlines
Wed, Dec 31 - Wed, Jan 7
Frontier Logo
3:16 pm - 10:23 am
DTW
-
STL
20h 07m1 stop
Frontier Logo
5:42 pm - 10:54 am
STL
-
DTW
16h 12m1 stop
$184Frontier
Thu, Jan 22 - Mon, Jan 26
Frontier Logo
5:14 pm - 2:46 pm
DTW
-
STL
22h 32m1 stop
Frontier Logo
1:03 pm - 11:59 pm
STL
-
DTW
9h 56m1 stop
$192Frontier
Fri, Jan 30 - Sun, Feb 1
Frontier Logo
12:35 pm - 9:47 am
DTW
-
STL
22h 12m1 stop
Frontier Logo
7:43 pm - 11:10 am
STL
-
DTW
14h 27m1 stop
$198Frontier
Thu, Feb 26 - Wed, Mar 4
Multiple Airlines Logo
6:00 am - 10:33 pm
DTW
-
STL
17h 33m2 stops
Multiple Airlines Logo
10:42 am - 11:40 am
STL
-
DTW
23h 58m1 stop
$202Multiple Airlines
Thu, Feb 19 - Sun, Feb 22

Frontier flights from Detroit Metropolitan Wayne County Airport to St. Louis

Our best Frontier deals on Detroit Metropolitan Wayne County Airport to St. Louis flight tickets
Frontier
Feb 21
DTW4:07 pmDetroit Metropolitan Wayne County
16h 43m
1 stop
STL7:50 amLambert-St Louis
Feb 22
STL8:36 pmLambert-St Louis
14h 16m
1 stop
DTW11:52 amDetroit Metropolitan Wayne County
$154
Find similar
Frontier
Feb 19
DTW6:07 pmDetroit Metropolitan Wayne County
14h 43m
1 stop
STL7:50 amLambert-St Louis
Feb 22
STL8:36 pmLambert-St Louis
14h 16m
1 stop
DTW11:52 amDetroit Metropolitan Wayne County
$157
Find similar
Frontier
Jan 8
DTW4:43 pmDetroit Metropolitan Wayne County
18h 19m
1 stop
STL10:02 amLambert-St Louis
Jan 12
STL7:43 pmLambert-St Louis
25h 13m
2 stops
DTW9:56 pmDetroit Metropolitan Wayne County
$164
Find similar

American Airlines flights from Detroit Metropolitan Wayne County Airport to St. Louis

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to St. Louis flight tickets
American Airlines
Dec 31
DTW9:40 amDetroit Metropolitan Wayne County
7h 43m
1 stop
STL4:23 pmLambert-St Louis
Jan 7
STL6:00 amLambert-St Louis
10h 25m
1 stop
DTW5:25 pmDetroit Metropolitan Wayne County
$177
Find similar
American Airlines
Jan 7
DTW1:08 pmDetroit Metropolitan Wayne County
9h 07m
1 stop
STL9:15 pmLambert-St Louis
Jan 10
STL11:55 amLambert-St Louis
7h 49m
1 stop
DTW8:44 pmDetroit Metropolitan Wayne County
$211
Find similar
American Airlines
Feb 26
DTW11:29 amDetroit Metropolitan Wayne County
6h 36m
1 stop
STL5:05 pmLambert-St Louis
Mar 4
STL10:23 amLambert-St Louis
6h 49m
1 stop
DTW6:12 pmDetroit Metropolitan Wayne County
$223
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 2/21

4:07 pm-7:50 am

1 stop16h 43m

Lambert-St Louis

Sun 2/22

8:36 pm-11:52 am

1 stop14h 16m

$154

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/8

4:43 pm-10:02 am

1 stop18h 19m

Lambert-St Louis

Mon 1/12

5:11 pm-1:52 pm

1 stop19h 41m

$155

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 2/19

6:07 pm-7:50 am

1 stop14h 43m

Lambert-St Louis

Sun 2/22

8:36 pm-11:52 am

1 stop14h 16m

$157

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/8

4:43 pm-10:02 am

1 stop18h 19m

Lambert-St Louis

Mon 1/12

7:43 pm-9:56 pm

2 stops25h 13m

$164

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/8

6:13 pm-2:48 pm

1 stop21h 35m

Lambert-St Louis

Mon 1/12

5:11 pm-1:52 pm

1 stop19h 41m

$168

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 12/31

9:40 am-4:23 pm

1 stop7h 43m

Lambert-St Louis

Wed 1/7

6:00 am-5:25 pm

1 stop10h 25m

$177

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 1/22

3:16 pm-10:23 am

1 stop20h 07m

Lambert-St Louis

Mon 1/26

5:42 pm-10:54 am

1 stop16h 12m

$184

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 1/30

5:14 pm-2:46 pm

1 stop22h 32m

Lambert-St Louis

Sun 2/1

1:03 pm-11:59 pm

1 stop9h 56m

$192

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 2/26

12:35 pm-9:47 am

1 stop22h 12m

Lambert-St Louis

Wed 3/4

7:43 pm-11:10 am

1 stop14h 27m

$198

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 2/19

6:00 am-10:33 pm

2 stops17h 33m

Lambert-St Louis

Sun 2/22

10:42 am-11:40 am

1 stop23h 58m

$202

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, July is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $121. The month of August is another great option to travel to St. Louis, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $154.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Friday when prices can be found for as low as $299. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $384. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Detroit Metropolitan Wayne County Airport at noon is the least expensive time of day to depart. momondo users have found prices as low as $298 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $329 per ticket.

What is the cheapest Detroit Metropolitan Wayne County to Lambert-St Louis flight route?

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit Metropolitan Wayne County - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $269 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit Metropolitan Wayne County Airport for as low as $69 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to Lambert-St Louis flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to St. Louis.

How have Detroit Metropolitan Wayne County Airport to St. Louis flight prices changed over time?

As of December 2025, prices for Detroit Metropolitan Wayne County Airport to St. Louis flights are approximately 27% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to St. Louis (DTW to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to St. Louis

Best Price Found

$229

Fastest flight time

1h 35m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Detroit Metropolitan Wayne County Airport in the past 72 hours is $229. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to St. Louis found on momondo in the last 72 hours is $332.
The fastest flight from Detroit Metropolitan Wayne County Airport to St. Louis takes 1h 35m
Direct flights go from Detroit Metropolitan Wayne County Airport to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Lambert-St Louis by plane?

    The distance between Detroit Metropolitan Wayne County and Lambert-St Louis is about 436.9 mi. In terms of flight time, this usually takes a little over 1h 40m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Lambert-St Louis Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The necessary travel and health documents for your Lambert-St Louis Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to St. Louis?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to St. Louis?

Best airlines flying from Detroit Metropolitan Wayne County Airport to St. Louis

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $36Free CancellationRating
6.3
8,161 reviews
Search Spirit Airlines flights
FrontierPriceFrom $111Free CancellationRating
5.8
3,092 reviews
Search Frontier flights
DeltaPriceFrom $136Free CancellationRating
7.9
8,011 reviews
Search Delta flights
SouthwestPriceFrom $137Free CancellationRating
8.0
4,252 reviews
Search Southwest flights

  • Southwest Flights From Detroit Metropolitan Wayne County Airport to St. Louis

    The lowest priced Southwest flight from Detroit Metropolitan Wayne County Airport to St. Louis from the last 72 hours was $137. Generally, Southwest has 5 flights on this route every week with an average price of $292. Southwest is rated 8.0/10 by our users.

  • Delta Flights From Detroit Metropolitan Wayne County Airport to St. Louis

    Delta is also a popular choice for this route. Delta flight deals for Detroit Metropolitan Wayne County Airport to St. Louis start from as low as $136 round-trip, depending on your selected dates, with average Delta deals seen on momondo around $308. Delta operates 12 flights to St. Louis from Detroit Metropolitan Wayne County Airport in an average week. Users have rated it 7.9/10 across 8,011 reviews.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
Collinsville
St. Peters
Alton
Farmington
Clayton
Festus
Glencoe
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Detroit.

Can I find flights from Detroit to St. Louis with flexible booking policies on momondo?

All flight searches from Detroit to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to St. Louis?

Once all potential Detroit to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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