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Cheap flights from Des Moines to St. Louis from $70

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 5/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:30 am - 11:30 am
DSM
-
STL
6h 00m
1 stop
Southwest Logo
3:55 pm - 9:15 pm
STL
-
DSM
5h 20m
1 stop
$279Southwest
Wed, Apr 29 - Wed, May 6
Southwest Logo
5:30 am - 9:30 am
DSM
-
STL
4h 00m
1 stop
Southwest Logo
3:10 pm - 10:10 pm
STL
-
DSM
7h 00m
2 stops
$284Southwest
Wed, Apr 29 - Wed, May 6
Southwest Logo
5:30 am - 11:30 am
DSM
-
STL
6h 00m
1 stop
Southwest Logo
5:40 am - 11:30 am
STL
-
DSM
5h 50m
1 stop
$288Southwest
Tue, Apr 21 - Sat, Apr 25
Southwest Logo
5:30 am - 3:15 pm
DSM
-
STL
9h 45m
2 stops
Southwest Logo
3:10 pm - 10:10 pm
STL
-
DSM
7h 00m
2 stops
$289Southwest
Wed, Apr 29 - Wed, May 6
Southwest Logo
5:30 am - 3:15 pm
DSM
-
STL
9h 45m
2 stops
Southwest Logo
5:40 am - 11:30 am
STL
-
DSM
5h 50m
1 stop
$293Southwest
Tue, Apr 21 - Sat, Apr 25
Delta Logo
4:00 pm - 9:29 pm
DSM
-
STL
5h 29m
1 stop
Delta Logo
5:36 pm - 9:03 pm
STL
-
DSM
3h 27m
1 stop
$297Delta
Sat, May 16 - Sat, May 23
Southwest Logo
6:55 am - 1:00 pm
DSM
-
STL
6h 05m
2 stops
Southwest Logo
6:10 am - 1:30 pm
STL
-
DSM
7h 20m
2 stops
$298Southwest
Tue, Apr 21 - Sat, Apr 25
Delta Logo
11:57 am - 6:00 pm
DSM
-
STL
6h 03m
1 stop
Delta Logo
6:45 am - 3:44 pm
STL
-
DSM
8h 59m
2 stops
$302Delta
Sat, May 16 - Sat, May 23
Southwest Logo
6:55 am - 1:00 pm
DSM
-
STL
6h 05m
2 stops
Southwest Logo
9:55 am - 11:05 pm
STL
-
DSM
13h 10m
2 stops
$304Southwest
Tue, May 5 - Thu, May 7
Southwest Logo
1:45 pm - 9:05 pm
DSM
-
STL
7h 20m
1 stop
Southwest Logo
5:25 am - 11:25 am
STL
-
DSM
6h 00m
1 stop
$307Southwest
Thu, Apr 30 - Sun, May 3

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
May 16
DSM4:00 pmDes Moines
5h 29m
1 stop
STL9:29 pmLambert-St Louis
May 23
STL5:36 pmLambert-St Louis
3h 27m
1 stop
DSM9:03 pmDes Moines
$297
Delta
May 16
DSM11:57 amDes Moines
6h 03m
1 stop
STL6:00 pmLambert-St Louis
May 23
STL6:45 amLambert-St Louis
8h 59m
2 stops
DSM3:44 pmDes Moines
$302
Delta
Apr 16
DSM6:31 pmDes Moines
5h 05m
1 stop
STL11:36 pmLambert-St Louis
Apr 23
STL6:20 amLambert-St Louis
3h 56m
1 stop
DSM10:16 amDes Moines
$311

United Airlines flights from Des Moines to St. Louis

Our best United Airlines deals on Des Moines to St. Louis flight tickets
United Airlines
Jun 2
DSM6:00 amDes Moines
6h 11m
1 stop
STL12:11 pmLambert-St Louis
Jun 3
STL6:00 amLambert-St Louis
4h 27m
1 stop
DSM10:27 amDes Moines
$349
United Airlines
Jun 2
DSM1:35 pmDes Moines
7h 08m
1 stop
STL8:43 pmLambert-St Louis
Jun 3
STL6:00 amLambert-St Louis
4h 27m
1 stop
DSM10:27 amDes Moines
$359
United Airlines
Apr 6
DSM3:21 pmDes Moines
5h 52m
1 stop
STL9:13 pmLambert-St Louis
Apr 8
STL7:45 amLambert-St Louis
4h 44m
1 stop
DSM12:29 pmDes Moines
$365

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-11:30 am

1 stop6h 00m

Lambert-St Louis

Wed 5/6

3:55 pm-9:15 pm

1 stop5h 20m

$279

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-9:30 am

1 stop4h 00m

Lambert-St Louis

Wed 5/6

3:10 pm-10:10 pm

2 stops7h 00m

$284

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/21

5:30 am-11:30 am

1 stop6h 00m

Lambert-St Louis

Sat 4/25

5:40 am-11:30 am

1 stop5h 50m

$288

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-3:15 pm

2 stops9h 45m

Lambert-St Louis

Wed 5/6

3:10 pm-10:10 pm

2 stops7h 00m

$289

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/21

5:30 am-3:15 pm

2 stops9h 45m

Lambert-St Louis

Sat 4/25

5:40 am-11:30 am

1 stop5h 50m

$293
Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/16

4:00 pm-9:29 pm

1 stop5h 29m

Lambert-St Louis

Sat 5/23

5:36 pm-9:03 pm

1 stop3h 27m

$297

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/21

6:55 am-1:00 pm

2 stops6h 05m

Lambert-St Louis

Sat 4/25

6:10 am-1:30 pm

2 stops7h 20m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/16

11:57 am-6:00 pm

1 stop6h 03m

Lambert-St Louis

Sat 5/23

6:45 am-3:44 pm

2 stops8h 59m

$302

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 5/5

6:55 am-1:00 pm

2 stops6h 05m

Lambert-St Louis

Thu 5/7

9:55 am-11:05 pm

2 stops13h 10m

$304

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 4/30

1:45 pm-9:05 pm

1 stop7h 20m

Lambert-St Louis

Sun 5/3

5:25 am-11:25 am

1 stop6h 00m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and St. Louis?

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $350. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $418. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $364 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $396 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$462

Fastest flight time

4h 15m

Direct flights

None
The best flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $462
The fastest flight from Des Moines to St. Louis takes 4h 15m
There are no direct flights from Des Moines to St. Louis. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to St. Louis

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 4h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $107Free CancellationRating
8.0
4,337 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Clayton
Festus
Eureka
Edwardsville
Litchfield
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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