Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to St. Louis from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 2/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
12:04 pm - 4:37 pm
DSM
-
STL
4h 33m1 stop
Delta Logo
6:35 am - 11:24 am
STL
-
DSM
4h 49m1 stop
$159Delta
Wed, Jan 14 - Thu, Jan 15
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
Delta Logo
6:00 am - 10:41 am
STL
-
DSM
4h 41m1 stop
$164Delta
Thu, Jan 22 - Mon, Jan 26
Delta Logo
10:30 am - 4:45 pm
DSM
-
STL
6h 15m1 stop
Delta Logo
6:35 am - 3:40 pm
STL
-
DSM
9h 05m2 stops
$194Delta
Wed, Feb 11 - Wed, Feb 18
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
Delta Logo
6:10 am - 10:19 am
STL
-
DSM
4h 09m1 stop
$214Delta
Mon, Jan 26 - Mon, Feb 2
Multiple Airlines Logo
7:32 pm - 1:09 pm
DSM
-
STL
17h 37m1 stop
Multiple Airlines Logo
10:11 pm - 10:51 pm
STL
-
DSM
24h 40m1 stop
$241Multiple Airlines
Thu, Feb 12 - Thu, Feb 19
American Airlines Logo
7:44 pm - 11:35 pm
DSM
-
STL
3h 51m1 stop
American Airlines Logo
5:12 am - 10:34 am
STL
-
DSM
5h 22m1 stop
$244American Airlines
Fri, Mar 6 - Fri, Mar 13
Frontier Logo
7:32 pm - 1:09 pm
DSM
-
STL
17h 37m1 stop
Frontier Logo
10:11 pm - 6:19 pm
STL
-
DSM
20h 08m2 stops
$248Frontier
Thu, Feb 12 - Thu, Feb 19
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
Delta Logo
6:35 am - 3:41 pm
STL
-
DSM
9h 06m2 stops
$265Delta
Thu, Jan 22 - Mon, Jan 26
Southwest Logo
3:20 pm - 4:35 pm
DSM
-
STL
1h 15mnonstop
Southwest Logo
1:45 pm - 2:55 pm
STL
-
DSM
1h 10mnonstop
$267Southwest
Wed, Jan 21 - Sat, Jan 24
United Airlines Logo
8:00 am - 2:30 pm
DSM
-
STL
6h 30m1 stop
United Airlines Logo
4:15 pm - 11:44 pm
STL
-
DSM
7h 29m1 stop
$274United Airlines
Sun, Jan 18 - Tue, Jan 20

United Airlines flights from Des Moines to St. Louis

Our best United Airlines deals on Des Moines to St. Louis flight tickets
United Airlines
Jan 18
DSM8:00 amDes Moines
6h 30m
1 stop
STL2:30 pmLambert-St Louis
Jan 20
STL4:15 pmLambert-St Louis
7h 29m
1 stop
DSM11:44 pmDes Moines
$274
Find similar
United Airlines
Apr 3
DSM1:10 pmDes Moines
6h 21m
1 stop
STL7:31 pmLambert-St Louis
Apr 5
STL8:21 amLambert-St Louis
6h 04m
1 stop
DSM2:25 pmDes Moines
$329
Find similar
United Airlines
Feb 10
DSM3:35 pmDes Moines
17h 47m
3 stops
STL9:22 amLambert-St Louis
Feb 17
STL7:41 amLambert-St Louis
6h 46m
1 stop
DSM2:27 pmDes Moines
$416
Find similar

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Jan 14
DSM12:04 pmDes Moines
4h 33m
1 stop
STL4:37 pmLambert-St Louis
Jan 15
STL6:35 amLambert-St Louis
4h 49m
1 stop
DSM11:24 amDes Moines
$159
Find similar
Delta
Jan 22
DSM10:59 amDes Moines
9h 44m
2 stops
STL8:43 pmLambert-St Louis
Jan 26
STL6:00 amLambert-St Louis
4h 41m
1 stop
DSM10:41 amDes Moines
$164
Find similar
Delta
Feb 11
DSM10:30 amDes Moines
6h 15m
1 stop
STL4:45 pmLambert-St Louis
Feb 18
STL6:35 amLambert-St Louis
9h 05m
2 stops
DSM3:40 pmDes Moines
$194
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 30, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/14

12:04 pm-4:37 pm

1 stop4h 33m

Lambert-St Louis

Thu 1/15

6:35 am-11:24 am

1 stop4h 49m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/22

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Mon 1/26

6:00 am-10:41 am

1 stop4h 41m

$164

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/11

10:30 am-4:45 pm

1 stop6h 15m

Lambert-St Louis

Wed 2/18

6:35 am-3:40 pm

2 stops9h 05m

$194

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 1/26

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Mon 2/2

6:10 am-10:19 am

1 stop4h 09m

$214

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/12

7:32 pm-1:09 pm

1 stop17h 37m

Lambert-St Louis

Thu 2/19

10:11 pm-10:51 pm

1 stop24h 40m

$241

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/6

7:44 pm-11:35 pm

1 stop3h 51m

Lambert-St Louis

Fri 3/13

5:12 am-10:34 am

1 stop5h 22m

$244

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/12

7:32 pm-1:09 pm

1 stop17h 37m

Lambert-St Louis

Thu 2/19

10:11 pm-6:19 pm

2 stops20h 08m

$248

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/22

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Mon 1/26

6:35 am-3:41 pm

2 stops9h 06m

$265

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/21

3:20 pm-4:35 pm

Nonstop1h 15m

Lambert-St Louis

Sat 1/24

1:45 pm-2:55 pm

Nonstop1h 10m

$267

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 1/18

8:00 am-2:30 pm

1 stop6h 30m

Lambert-St Louis

Tue 1/20

4:15 pm-11:44 pm

1 stop7h 29m

$274

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $363. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $418. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $386 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $407 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$199

Fastest flight time

1h 05m

Direct flights

Wed, Thu, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $199. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $377.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Wednesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Des Moines there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,251 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $97. Generally, Southwest has 8 flights on this route every week with an average price of $254. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Collinsville
St. Peters
Wentzville
Alton
Farmington
Clayton
Glencoe
Eureka
Festus
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 1/29
Thu 2/5
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States