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Cheap flights from Des Moines to St. Louis from $58

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 2/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
10:57 am - 4:47 pmDSM-STL
5h 50m1 stop
Delta Logo
5:29 pm - 9:19 pmSTL-DSM
3h 50m1 stop
$157Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
10:57 am - 8:45 pmDSM-STL
9h 48m2 stops
Delta Logo
5:29 pm - 9:19 pmSTL-DSM
3h 50m1 stop
$162Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
10:57 am - 8:45 pmDSM-STL
9h 48m2 stops
Delta Logo
7:10 am - 4:59 pmSTL-DSM
9h 49m2 stops
$203Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
Southwest Logo
6:10 am - 7:30 amDSM-STL
1h 20mnonstop
Southwest Logo
3:00 pm - 9:20 pmSTL-DSM
6h 20m1 stop
$329Southwest
Find Deal
Fri, Jan 23 - Sun, Jan 25
Delta Logo
10:54 am - 8:45 pmDSM-STL
9h 51m2 stops
Delta Logo
3:31 pm - 9:24 pmSTL-DSM
5h 53m1 stop
$334Delta
Find Deal
Fri, Jan 23 - Sun, Jan 25
Delta Logo
6:32 pm - 11:44 pmDSM-STL
5h 12m1 stop
Delta Logo
6:00 am - 10:21 amSTL-DSM
4h 21m1 stop
$351Delta
Find Deal
Mon, Dec 1 - Tue, Dec 2
American Airlines Logo
8:58 am - 4:25 pmDSM-STL
7h 27m1 stop
American Airlines Logo
7:58 pm - 11:44 pmSTL-DSM
3h 46m1 stop
$369American Airlines
Find Deal
Thu, Nov 27 - Mon, Dec 1
Delta Logo
10:57 am - 8:45 pmDSM-STL
9h 48m2 stops
Delta Logo
6:00 am - 4:59 pmSTL-DSM
10h 59m2 stops
$378Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
4:59 pm - 11:23 pmDSM-STL
6h 24m1 stop
Delta Logo
5:12 pm - 10:34 pmSTL-DSM
5h 22m1 stop
$392Delta
Find Deal
Mon, Dec 1 - Tue, Dec 2
Southwest Logo
6:35 am - 12:20 pmDSM-STL
5h 45m1 stop
Southwest Logo
10:15 am - 11:25 amSTL-DSM
1h 10mnonstop
$395Southwest
Find Deal
Mon, Dec 1 - Tue, Dec 2

United Airlines flights from Des Moines to St. Louis

Our best United Airlines deals on Des Moines to St. Louis flight tickets
United Airlines
Nov 24
DSM8:02 amDes Moines
7h 44m
1 stop
STL3:46 pmLambert-St Louis
Nov 27
STL8:00 amLambert-St Louis
6h 19m
1 stop
DSM2:19 pmDes Moines
$489
Find similar
United Airlines
Nov 24
DSM8:02 amDes Moines
7h 44m
1 stop
STL3:46 pmLambert-St Louis
Nov 27
STL8:25 amLambert-St Louis
26h 05m
2 stops
DSM10:30 amDes Moines
$687
Find similar
United Airlines
Nov 27
DSM8:02 amDes Moines
26h 05m
2 stops
STL10:07 amLambert-St Louis
Dec 1
STL5:24 pmLambert-St Louis
4h 08m
1 stop
DSM9:32 pmDes Moines
$726
Find similar

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Mar 3
DSM10:57 amDes Moines
4h 01m
1 stop
STL2:58 pmLambert-St Louis
Mar 4
STL6:00 amLambert-St Louis
4h 43m
1 stop
DSM10:43 amDes Moines
$157
Find similar
Delta
Mar 3
DSM10:57 amDes Moines
9h 48m
2 stops
STL8:45 pmLambert-St Louis
Mar 4
STL6:00 amLambert-St Louis
4h 43m
1 stop
DSM10:43 amDes Moines
$162
Find similar
Delta
Mar 3
DSM10:57 amDes Moines
9h 48m
2 stops
STL8:45 pmLambert-St Louis
Mar 4
STL7:10 amLambert-St Louis
9h 49m
2 stops
DSM4:59 pmDes Moines
$203
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-4:47 pm

1 stop5h 50m

Lambert-St Louis

Wed 3/4

5:29 pm-9:19 pm

1 stop3h 50m

$157

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-8:45 pm

2 stops9h 48m

Lambert-St Louis

Wed 3/4

5:29 pm-9:19 pm

1 stop3h 50m

$162

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-8:45 pm

2 stops9h 48m

Lambert-St Louis

Wed 3/4

7:10 am-4:59 pm

2 stops9h 49m

$203

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/23

6:10 am-7:30 am

Nonstop1h 20m

Lambert-St Louis

Sun 1/25

3:00 pm-9:20 pm

1 stop6h 20m

$329

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/23

10:54 am-8:45 pm

2 stops9h 51m

Lambert-St Louis

Sun 1/25

3:31 pm-9:24 pm

1 stop5h 53m

$334

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 12/1

6:32 pm-11:44 pm

1 stop5h 12m

Lambert-St Louis

Tue 12/2

6:00 am-10:21 am

1 stop4h 21m

$351

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 11/27

8:58 am-4:25 pm

1 stop7h 27m

Lambert-St Louis

Mon 12/1

7:58 pm-11:44 pm

1 stop3h 46m

$369

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-8:45 pm

2 stops9h 48m

Lambert-St Louis

Wed 3/4

6:00 am-4:59 pm

2 stops10h 59m

$378

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 12/1

4:59 pm-11:23 pm

1 stop6h 24m

Lambert-St Louis

Tue 12/2

5:12 pm-10:34 pm

1 stop5h 22m

$392

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 12/1

6:35 am-12:20 pm

1 stop5h 45m

Lambert-St Louis

Tue 12/2

10:15 am-11:25 am

Nonstop1h 10m

$395

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $182. The month of August is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $225.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $375. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $427. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $394 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $413 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$185

Fastest flight time

1h 05m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $185. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $310.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $97. Generally, Southwest has 12 flights on this route every week with an average price of $267. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Wentzville
Fenton
Collinsville
St. Peters
Alton
Farmington
Festus
Glencoe
Edwardsville
Clayton
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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