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Cheap flights from Des Moines to St. Louis from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 7/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:00 pm - 11:55 pm
DSM
-
STL
4h 55m
1 stop
Southwest Logo
6:30 am - 11:50 am
STL
-
DSM
5h 20m
1 stop
$209Southwest
Tue, Jul 28 - Tue, Aug 4
Southwest Logo
5:20 am - 2:50 pm
DSM
-
STL
9h 30m
2 stops
Southwest Logo
3:45 pm - 9:55 pm
STL
-
DSM
6h 10m
1 stop
$214Southwest
Tue, Jul 28 - Tue, Aug 4
Delta Logo
6:55 am - 10:23 am
DSM
-
STL
3h 28m
1 stop
Delta Logo
6:20 am - 10:18 am
STL
-
DSM
3h 58m
1 stop
$215Delta
Thu, Aug 13 - Thu, Aug 20
Southwest Logo
5:20 am - 2:45 pm
DSM
-
STL
9h 25m
2 stops
Southwest Logo
3:05 pm - 9:55 pm
STL
-
DSM
6h 50m
2 stops
$219Southwest
Tue, Jul 28 - Tue, Aug 4
Southwest Logo
12:10 pm - 7:45 pm
DSM
-
STL
7h 35m
2 stops
Southwest Logo
8:30 am - 7:25 pm
STL
-
DSM
10h 55m
2 stops
$225Southwest
Sat, Aug 15 - Sat, Aug 22
Southwest Logo
5:40 am - 3:20 pm
DSM
-
STL
9h 40m
2 stops
Southwest Logo
5:40 am - 11:20 am
STL
-
DSM
5h 40m
1 stop
$230Southwest
Thu, Aug 20 - Thu, Oct 1
American Airlines Logo
7:49 pm - 12:14 am
DSM
-
STL
4h 25m
1 stop
American Airlines Logo
6:00 am - 9:56 am
STL
-
DSM
3h 56m
1 stop
$235American Airlines
Thu, Aug 13 - Thu, Aug 20
Southwest Logo
3:50 pm - 10:05 pm
DSM
-
STL
6h 15m
1 stop
Southwest Logo
10:10 am - 10:10 pm
STL
-
DSM
12h 00m
2 stops
$246Southwest
Thu, Aug 13 - Thu, Aug 20
Southwest Logo
5:40 am - 3:20 pm
DSM
-
STL
9h 40m
2 stops
Southwest Logo
10:15 am - 11:30 pm
STL
-
DSM
13h 15m
2 stops
$251Southwest
Thu, Aug 20 - Thu, Oct 1
Southwest Logo
5:30 am - 12:35 pm
DSM
-
STL
7h 05m
2 stops
Southwest Logo
5:45 am - 11:30 am
STL
-
DSM
5h 45m
1 stop
$267Southwest
Sat, Aug 8 - Sat, Aug 15

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Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Aug 13
DSM6:55 amDes Moines
3h 28m
1 stop
STL10:23 amLambert-St Louis
Aug 20
STL6:20 amLambert-St Louis
3h 58m
1 stop
DSM10:18 amDes Moines
$215
Delta
Jul 30
DSM5:52 pmDes Moines
5h 30m
1 stop
STL11:22 pmLambert-St Louis
Aug 6
STL6:20 amLambert-St Louis
3h 58m
1 stop
DSM10:18 amDes Moines
$280
Delta
Jul 30
DSM5:52 pmDes Moines
5h 30m
1 stop
STL11:22 pmLambert-St Louis
Aug 2
STL6:30 amLambert-St Louis
7h 35m
2 stops
DSM2:05 pmDes Moines
$487

American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Aug 13
DSM7:49 pmDes Moines
4h 25m
1 stop
STL12:14 amLambert-St Louis
Aug 20
STL6:00 amLambert-St Louis
3h 56m
1 stop
DSM9:56 amDes Moines
$235
American Airlines
Jul 26
DSM5:00 amDes Moines
3h 37m
1 stop
STL8:37 amLambert-St Louis
Jul 28
STL5:58 pmLambert-St Louis
6h 03m
1 stop
DSM12:01 amDes Moines
$277
American Airlines
Jul 30
DSM7:03 pmDes Moines
5h 13m
1 stop
STL12:16 amLambert-St Louis
Aug 2
STL5:58 pmLambert-St Louis
6h 03m
1 stop
DSM12:01 amDes Moines
$397

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/28

7:00 pm-11:55 pm

1 stop4h 55m

Lambert-St Louis

Tue 8/4

6:30 am-11:50 am

1 stop5h 20m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/28

5:20 am-2:50 pm

2 stops9h 30m

Lambert-St Louis

Tue 8/4

3:45 pm-9:55 pm

1 stop6h 10m

$214
Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/13

6:55 am-10:23 am

1 stop3h 28m

Lambert-St Louis

Thu 8/20

6:20 am-10:18 am

1 stop3h 58m

$215

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/28

5:20 am-2:45 pm

2 stops9h 25m

Lambert-St Louis

Tue 8/4

3:05 pm-9:55 pm

2 stops6h 50m

$219

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 8/15

12:10 pm-7:45 pm

2 stops7h 35m

Lambert-St Louis

Sat 8/22

8:30 am-7:25 pm

2 stops10h 55m

$225

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/20

5:40 am-3:20 pm

2 stops9h 40m

Lambert-St Louis

Thu 10/1

5:40 am-11:20 am

1 stop5h 40m

$230

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/13

7:49 pm-12:14 am

1 stop4h 25m

Lambert-St Louis

Thu 8/20

6:00 am-9:56 am

1 stop3h 56m

$235

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/13

3:50 pm-10:05 pm

1 stop6h 15m

Lambert-St Louis

Thu 8/20

10:10 am-10:10 pm

2 stops12h 00m

$246

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/20

5:40 am-3:20 pm

2 stops9h 40m

Lambert-St Louis

Thu 10/1

10:15 am-11:30 pm

2 stops13h 15m

$251

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 8/8

5:30 am-12:35 pm

2 stops7h 05m

Lambert-St Louis

Sat 8/15

5:45 am-11:30 am

1 stop5h 45m

$267

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, November is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of May is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $116.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $355. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $409. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $354 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $392 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to St. Louis flights?

There is only 1 cabin class available to choose from on Des Moines to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$462

Fastest flight time

3h 28m

Direct flights

None
The best flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $462
The fastest flight from Des Moines to St. Louis takes 3h 28m
There are no direct flights from Des Moines to St. Louis. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to St. Louis

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 3h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $107Free CancellationRating
7.9
4,250 reviews
Search Southwest flights
American AirlinesPriceFrom $158Free CancellationRating
7.1
11,768 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
Maryland Heights
Florissant
O'Fallon
St. Peters
Collinsville
Alton
Fenton
Farmington
Wentzville
Clayton
Festus
Eureka
Litchfield
Edwardsville
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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