Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to St. Louis from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:16 pm - 7:23 pm
DSM
-
STL
5h 07m
1 stop
Frontier Logo
8:08 pm - 1:31 pm
STL
-
DSM
17h 23m
1 stop
$242Frontier
Wed, May 27 - Sun, May 31
United Airlines Logo
6:00 am - 12:11 pm
DSM
-
STL
6h 11m
1 stop
United Airlines Logo
6:00 am - 10:30 am
STL
-
DSM
4h 30m
1 stop
$305United Airlines
Tue, Jun 16 - Thu, Jun 18
Southwest Logo
6:30 pm - 11:10 pm
DSM
-
STL
4h 40m
1 stop
Southwest Logo
6:30 pm - 11:30 pm
STL
-
DSM
5h 00m
1 stop
$309Southwest
Wed, Jun 3 - Fri, Jun 5
Southwest Logo
5:20 am - 2:45 pm
DSM
-
STL
9h 25m
2 stops
Southwest Logo
5:50 am - 11:25 am
STL
-
DSM
5h 35m
1 stop
$310Southwest
Wed, Jul 1 - Sun, Jul 5
Frontier Logo
2:16 pm - 7:23 pm
DSM
-
STL
5h 07m
1 stop
Frontier Logo
8:08 pm - 1:31 pm
STL
-
DSM
17h 23m
1 stop
$313Frontier
Fri, May 29 - Tue, Jun 2
Southwest Logo
5:30 am - 9:30 am
DSM
-
STL
4h 00m
1 stop
Southwest Logo
2:30 pm - 11:30 pm
STL
-
DSM
9h 00m
2 stops
$314Southwest
Wed, Jun 3 - Fri, Jun 5
Southwest Logo
6:50 am - 7:15 pm
DSM
-
STL
12h 25m
2 stops
Southwest Logo
2:20 pm - 10:05 pm
STL
-
DSM
7h 45m
2 stops
$315Southwest
Sat, Oct 31 - Tue, Nov 3
American Airlines Logo
4:48 pm - 11:59 pm
DSM
-
STL
7h 11m
1 stop
American Airlines Logo
5:58 pm - 12:01 am
STL
-
DSM
6h 03m
1 stop
$317American Airlines
Sat, Jun 27 - Sun, Jul 5
Southwest Logo
5:30 am - 12:50 pm
DSM
-
STL
7h 20m
2 stops
Southwest Logo
2:30 pm - 11:30 pm
STL
-
DSM
9h 00m
2 stops
$319Southwest
Wed, Jun 3 - Fri, Jun 5
Southwest Logo
6:55 pm - 11:45 pm
DSM
-
STL
4h 50m
1 stop
Southwest Logo
10:15 am - 10:45 pm
STL
-
DSM
12h 30m
2 stops
$320Southwest
Sat, Jun 13 - Wed, Jun 17

Southwest flights from Des Moines to St. Louis

Our best Southwest deals on Des Moines to St. Louis flight tickets
Southwest
Jun 3
DSM6:30 pmDes Moines
4h 40m
1 stop
STL11:10 pmLambert-St Louis
Jun 5
STL6:30 pmLambert-St Louis
5h 00m
1 stop
DSM11:30 pmDes Moines
$309
Southwest
Jul 1
DSM5:20 amDes Moines
9h 25m
2 stops
STL2:45 pmLambert-St Louis
Jul 5
STL5:50 amLambert-St Louis
5h 35m
1 stop
DSM11:25 amDes Moines
$310
Southwest
Jun 3
DSM5:30 amDes Moines
4h 00m
1 stop
STL9:30 amLambert-St Louis
Jun 5
STL2:30 pmLambert-St Louis
9h 00m
2 stops
DSM11:30 pmDes Moines
$314

American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Jun 27
DSM7:02 pmDes Moines
4h 57m
1 stop
STL11:59 pmLambert-St Louis
Jul 5
STL5:58 pmLambert-St Louis
6h 03m
1 stop
DSM12:01 amDes Moines
$317
American Airlines
Jun 3
DSM8:12 pmDes Moines
4h 02m
1 stop
STL12:14 amLambert-St Louis
Jun 5
STL8:36 amLambert-St Louis
7h 27m
1 stop
DSM4:03 pmDes Moines
$323
American Airlines
May 31
DSM8:02 pmDes Moines
3h 52m
1 stop
STL11:54 pmLambert-St Louis
Jun 4
STL7:20 pmLambert-St Louis
4h 38m
1 stop
DSM11:58 pmDes Moines
$447

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 5/27

2:16 pm-7:23 pm

1 stop5h 07m

Lambert-St Louis

Sun 5/31

8:08 pm-1:31 pm

1 stop17h 23m

$242

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 6/16

6:00 am-12:11 pm

1 stop6h 11m

Lambert-St Louis

Thu 6/18

6:00 am-10:30 am

1 stop4h 30m

$305
Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 6/3

6:30 pm-11:10 pm

1 stop4h 40m

Lambert-St Louis

Fri 6/5

6:30 pm-11:30 pm

1 stop5h 00m

$309

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 7/1

5:20 am-2:45 pm

2 stops9h 25m

Lambert-St Louis

Sun 7/5

5:50 am-11:25 am

1 stop5h 35m

$310

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 5/29

2:16 pm-7:23 pm

1 stop5h 07m

Lambert-St Louis

Tue 6/2

8:08 pm-1:31 pm

1 stop17h 23m

$313

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 6/3

5:30 am-9:30 am

1 stop4h 00m

Lambert-St Louis

Fri 6/5

2:30 pm-11:30 pm

2 stops9h 00m

$314

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 10/31

6:50 am-7:15 pm

2 stops12h 25m

Lambert-St Louis

Tue 11/3

2:20 pm-10:05 pm

2 stops7h 45m

$315

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/27

4:48 pm-11:59 pm

1 stop7h 11m

Lambert-St Louis

Sun 7/5

5:58 pm-12:01 am

1 stop6h 03m

$317

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 6/3

5:30 am-12:50 pm

2 stops7h 20m

Lambert-St Louis

Fri 6/5

2:30 pm-11:30 pm

2 stops9h 00m

$319

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/13

6:55 pm-11:45 pm

1 stop4h 50m

Lambert-St Louis

Wed 6/17

10:15 am-10:45 pm

2 stops12h 30m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, November is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of September is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $182.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $356. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $409. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $359 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $388 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$462

Fastest flight time

3h 28m

Direct flights

None
The best flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $462
The fastest flight from Des Moines to St. Louis takes 3h 28m
There are no direct flights from Des Moines to St. Louis. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to St. Louis

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 3h 28m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $107Free CancellationRating
8.0
4,294 reviews
Search Southwest flights
American AirlinesPriceFrom $158Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 6/15
Mon 6/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States