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Cheap flights from Des Moines to St. Louis from $165

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:28 pm - 11:03 amDSM  Des Moines-STL Lambert-St Louis
14h 35m1 stop Denver Intl
Frontier Logo
7:58 pm - 7:40 pmSTL  Lambert-St Louis-DSM Des Moines
23h 42m1 stop Denver Intl
$212Frontier
Thu, Nov 26 - Wed, Dec 2
American Airlines Logo
7:31 pm - 12:19 amDSM  Des Moines-STL Lambert-St Louis
4h 48m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 8:46 amSTL  Lambert-St Louis-DSM Des Moines
3h 46m1 stop Chicago O'Hare Intl
$271American Airlines
Tue, Oct 27 - Tue, Nov 3
Southwest Logo
4:25 pm - 7:45 pmDSM  Des Moines-STL Lambert-St Louis
3h 20m1 stop Chicago Midway
Southwest Logo
6:30 am - 2:15 pmSTL  Lambert-St Louis-DSM Des Moines
7h 45m1 stop Denver Intl
$271Southwest
Mon, Nov 9 - Wed, Nov 11
United Airlines Logo
8:00 am - 2:29 pmDSM  Des Moines-STL Lambert-St Louis
6h 29m1 stop Chicago O'Hare Intl
United Airlines Logo
1:08 pm - 5:28 pmSTL  Lambert-St Louis-DSM Des Moines
4h 20m1 stop Chicago O'Hare Intl
$271United Airlines
Wed, Oct 28 - Wed, Nov 4
Southwest Logo
4:25 pm - 7:45 pmDSM  Des Moines-STL Lambert-St Louis
3h 20m1 stop Chicago Midway
Southwest Logo
2:20 pm - 10:05 pmSTL  Lambert-St Louis-DSM Des Moines
7h 45m2 stops Atlanta Hartsfield-Jackson Chicago Midway
$276Southwest
Mon, Nov 9 - Wed, Nov 11
Multiple Airlines Logo
8:28 pm - 11:03 amDSM  Des Moines-STL Lambert-St Louis
14h 35m1 stop Denver Intl
Multiple Airlines Logo
6:13 pm - 9:50 amSTL  Lambert-St Louis-DSM Des Moines
39h 37m2 stops Orlando Nashville Intl
$276Multiple Airlines
Thu, Nov 26 - Wed, Dec 2
Southwest Logo
6:35 pm - 11:15 pmDSM  Des Moines-STL Lambert-St Louis
4h 40m1 stop Denver Intl
Southwest Logo
2:20 pm - 10:05 pmSTL  Lambert-St Louis-DSM Des Moines
7h 45m2 stops Atlanta Hartsfield-Jackson Chicago Midway
$276Southwest
Wed, Oct 28 - Wed, Nov 4
United Airlines Logo
8:00 am - 2:18 pmDSM  Des Moines-STL Lambert-St Louis
6h 18m1 stop Chicago O'Hare Intl
United Airlines Logo
6:58 pm - 11:17 pmSTL  Lambert-St Louis-DSM Des Moines
4h 19m1 stop Chicago O'Hare Intl
$307United Airlines
Fri, Dec 25 - Fri, Dec 25
American Airlines Logo
7:24 pm - 11:54 pmDSM  Des Moines-STL Lambert-St Louis
4h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
5:29 pm - 12:19 amSTL  Lambert-St Louis-DSM Des Moines
6h 50m1 stop Chicago O'Hare Intl
$329American Airlines
Fri, Nov 27 - Tue, Dec 1
American Airlines Logo
7:31 pm - 12:19 amDSM  Des Moines-STL Lambert-St Louis
4h 48m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 8:56 amSTL  Lambert-St Louis-DSM Des Moines
3h 56m1 stop Chicago O'Hare Intl
$329American Airlines
Fri, Oct 23 - Mon, Oct 26

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American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Oct 27
DSM7:31 pmDes Moines
4h 48m
1 stop
STL12:19 amLambert-St Louis
Nov 3
STL5:00 amLambert-St Louis
3h 46m
1 stop
DSM8:46 amDes Moines
$271
American Airlines
Oct 23
DSM7:31 pmDes Moines
4h 48m
1 stop
STL12:19 amLambert-St Louis
Oct 26
STL5:00 amLambert-St Louis
3h 56m
1 stop
DSM8:56 amDes Moines
$329
American Airlines
Oct 23
DSM7:31 pmDes Moines
4h 48m
1 stop
STL12:19 amLambert-St Louis
Oct 25
STL5:00 amLambert-St Louis
3h 56m
1 stop
DSM8:56 amDes Moines
$344

Southwest flights from Des Moines to St. Louis

Our best Southwest deals on Des Moines to St. Louis flight tickets
Southwest
Oct 27
DSM5:35 amDes Moines
9h 25m
2 stops
STL3:00 pmLambert-St Louis
Nov 3
STL8:25 amLambert-St Louis
5h 50m
1 stop
DSM2:15 pmDes Moines
$276
Southwest
Oct 27
DSM5:35 amDes Moines
9h 20m
2 stops
STL2:55 pmLambert-St Louis
Nov 3
STL2:20 pmLambert-St Louis
7h 40m
2 stops
DSM10:00 pmDes Moines
$281
Southwest
Nov 26
DSM5:10 amDes Moines
8h 35m
2 stops
STL1:45 pmLambert-St Louis
Dec 2
STL2:20 pmLambert-St Louis
7h 45m
2 stops
DSM10:05 pmDes Moines
$299

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 11/26

8:28 pm-11:03 am

1 stop14h 35m

Lambert-St Louis

Wed 12/2

7:58 pm-7:40 pm

1 stop23h 42m

$212
Quickest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Tue 10/27

7:31 pm-12:19 am

1 stop4h 48m

Lambert-St Louis

Tue 11/3

5:00 am-8:46 am

1 stop3h 46m

$271

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Mon 11/9

4:25 pm-7:45 pm

1 stop3h 20m

Lambert-St Louis

Wed 11/11

6:30 am-2:15 pm

1 stop7h 45m

$271

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 10/28

8:00 am-2:29 pm

1 stop6h 29m

Lambert-St Louis

Wed 11/4

1:08 pm-5:28 pm

1 stop4h 20m

$271

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Mon 11/9

4:25 pm-7:45 pm

1 stop3h 20m

Lambert-St Louis

Wed 11/11

2:20 pm-10:05 pm

2 stops7h 45m

$276

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 11/26

8:28 pm-11:03 am

1 stop14h 35m

Lambert-St Louis

Wed 12/2

6:13 pm-9:50 am

2 stops39h 37m

$276

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 10/28

6:35 pm-11:15 pm

1 stop4h 40m

Lambert-St Louis

Wed 11/4

2:20 pm-10:05 pm

2 stops7h 45m

$276

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 12/25

8:00 am-2:18 pm

1 stop6h 18m

Lambert-St Louis

Fri 12/25

6:58 pm-11:17 pm

1 stop4h 19m

$307

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 11/27

7:24 pm-11:54 pm

1 stop4h 30m

Lambert-St Louis

Tue 12/1

5:29 pm-12:19 am

1 stop6h 50m

$329

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 10/23

7:31 pm-12:19 am

1 stop4h 48m

Lambert-St Louis

Mon 10/26

5:00 am-8:56 am

1 stop3h 56m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, November is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of July is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $0.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $364. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $462. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $396 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $414 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to St. Louis flights?

There is only 1 cabin class available to choose from on Des Moines to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$165

Fastest flight time

4h 40m

Direct flights

None
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $165. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $212.
The fastest flight from Des Moines to St. Louis takes 4h 40m
There are no direct flights from Des Moines to St. Louis. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to St. Louis

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 4h 40m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $116Free CancellationRating
7.9
4,216 reviews
Search Southwest flights
American AirlinesPriceFrom $158Free CancellationRating
7.0
12,131 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Maryland Heights
Fairview Heights
St. Peters
Alton
Collinsville
Florissant
Farmington
Clayton
Hermann
Festus
O'Fallon
Fenton
Edwardsville
Wentzville
Eureka
Litchfield
Grafton
Waterloo

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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