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Cheap flights from Des Moines to St. Louis from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
1:55 pm - 11:20 pm
DSM
-
STL
9h 25m
1 stop
Southwest Logo
5:40 am - 11:45 am
STL
-
DSM
6h 05m
1 stop
$149Southwest
Tue, Mar 31 - Mon, Apr 13
American Airlines Logo
5:01 pm - 10:17 pm
DSM
-
STL
5h 16m
1 stop
American Airlines Logo
8:03 pm - 11:49 pm
STL
-
DSM
3h 46m
1 stop
$181American Airlines
Sat, May 2 - Mon, May 4
American Airlines Logo
10:04 am - 1:50 pm
DSM
-
STL
3h 46m
1 stop
American Airlines Logo
5:12 am - 10:44 am
STL
-
DSM
5h 32m
1 stop
$182American Airlines
Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
7:44 pm - 11:48 pm
DSM
-
STL
4h 04m
1 stop
American Airlines Logo
5:12 am - 10:34 am
STL
-
DSM
5h 22m
1 stop
$188American Airlines
Thu, Mar 5 - Sun, Mar 8
American Airlines Logo
11:09 am - 4:41 pm
DSM
-
STL
5h 32m
1 stop
American Airlines Logo
5:46 am - 10:26 am
STL
-
DSM
4h 40m
1 stop
$189American Airlines
Fri, May 1 - Mon, May 4
Delta Logo
6:55 am - 11:48 am
DSM
-
STL
4h 53m
1 stop
Delta Logo
3:05 pm - 9:10 pm
STL
-
DSM
6h 05m
1 stop
$191Delta
Sat, Mar 28 - Sat, Apr 4
American Airlines Logo
7:44 pm - 11:35 pm
DSM
-
STL
3h 51m
1 stop
American Airlines Logo
5:12 am - 10:44 am
STL
-
DSM
5h 32m
1 stop
$193American Airlines
Fri, Mar 6 - Sat, Mar 7
American Airlines Logo
7:44 pm - 11:35 pm
DSM
-
STL
3h 51m
1 stop
American Airlines Logo
5:12 am - 10:34 am
STL
-
DSM
5h 22m
1 stop
$195American Airlines
Fri, Mar 6 - Sun, Mar 8
Southwest Logo
4:20 pm - 11:10 pm
DSM
-
STL
6h 50m
1 stop
Southwest Logo
4:45 pm - 11:15 pm
STL
-
DSM
6h 30m
1 stop
$196Southwest
Thu, Mar 26 - Mon, Mar 30
Delta Logo
10:57 am - 2:54 pm
DSM
-
STL
3h 57m
1 stop
Delta Logo
6:10 am - 10:17 am
STL
-
DSM
4h 07m
1 stop
$198Delta
Tue, Mar 3 - Thu, Mar 5

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Mar 28
DSM6:55 amDes Moines
4h 53m
1 stop
STL11:48 amLambert-St Louis
Apr 4
STL3:05 pmLambert-St Louis
6h 05m
1 stop
DSM9:10 pmDes Moines
$191
Delta
Mar 3
DSM10:57 amDes Moines
3h 57m
1 stop
STL2:54 pmLambert-St Louis
Mar 5
STL6:10 amLambert-St Louis
4h 07m
1 stop
DSM10:17 amDes Moines
$198
Delta
Mar 3
DSM5:24 amDes Moines
5h 38m
1 stop
STL11:02 amLambert-St Louis
Mar 3
STL3:40 pmLambert-St Louis
5h 40m
1 stop
DSM9:20 pmDes Moines
$205

American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
May 2
DSM5:01 pmDes Moines
5h 16m
1 stop
STL10:17 pmLambert-St Louis
May 4
STL8:03 pmLambert-St Louis
3h 46m
1 stop
DSM11:49 pmDes Moines
$181
American Airlines
Mar 28
DSM10:04 amDes Moines
3h 46m
1 stop
STL1:50 pmLambert-St Louis
Apr 4
STL5:12 amLambert-St Louis
5h 32m
1 stop
DSM10:44 amDes Moines
$182
American Airlines
Mar 5
DSM7:44 pmDes Moines
4h 04m
1 stop
STL11:48 pmLambert-St Louis
Mar 8
STL5:12 amLambert-St Louis
5h 22m
1 stop
DSM10:34 amDes Moines
$188

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/31

1:55 pm-11:20 pm

1 stop9h 25m

Lambert-St Louis

Mon 4/13

5:40 am-11:45 am

1 stop6h 05m

$149

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/2

5:01 pm-10:17 pm

1 stop5h 16m

Lambert-St Louis

Mon 5/4

8:03 pm-11:49 pm

1 stop3h 46m

$181

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 3/28

10:04 am-1:50 pm

1 stop3h 46m

Lambert-St Louis

Sat 4/4

5:12 am-10:44 am

1 stop5h 32m

$182

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 3/5

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Sun 3/8

5:12 am-10:34 am

1 stop5h 22m

$188

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 5/1

11:09 am-4:41 pm

1 stop5h 32m

Lambert-St Louis

Mon 5/4

5:46 am-10:26 am

1 stop4h 40m

$189

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 3/28

6:55 am-11:48 am

1 stop4h 53m

Lambert-St Louis

Sat 4/4

3:05 pm-9:10 pm

1 stop6h 05m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/6

7:44 pm-11:35 pm

1 stop3h 51m

Lambert-St Louis

Sat 3/7

5:12 am-10:44 am

1 stop5h 32m

$193

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/6

7:44 pm-11:35 pm

1 stop3h 51m

Lambert-St Louis

Sun 3/8

5:12 am-10:34 am

1 stop5h 22m

$195

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 3/26

4:20 pm-11:10 pm

1 stop6h 50m

Lambert-St Louis

Mon 3/30

4:45 pm-11:15 pm

1 stop6h 30m

$196

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-2:54 pm

1 stop3h 57m

Lambert-St Louis

Thu 3/5

6:10 am-10:17 am

1 stop4h 07m

$198

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $358. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $419. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $377 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $399 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$187

Fastest flight time

1h 05m

Direct flights

Thu

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $187. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $348.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Thursday. There are no airlines offering direct flights.
There is 1 airport in St. Louis. From Des Moines there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,283 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $97. Generally, Southwest has 9 flights on this route every week with an average price of $253. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Collinsville
St. Peters
Fenton
Wentzville
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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