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Cheap flights from Des Moines to St. Louis from $118

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 9/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:40 am - 10:30 amDSM  Des Moines-STL Lambert-St Louis
4h 50m1 stop Chicago Midway
Southwest Logo
3:15 pm - 10:15 pmSTL  Lambert-St Louis-DSM Des Moines
7h 00m2 stops Atlanta Hartsfield-Jackson Chicago Midway
$215Southwest
Thu, Sep 10 - Fri, Sep 11
Southwest Logo
5:40 am - 6:25 pmDSM  Des Moines-STL Lambert-St Louis
12h 45m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
3:45 pm - 10:15 pmSTL  Lambert-St Louis-DSM Des Moines
6h 30m2 stops Nashville Intl Chicago Midway
$221Southwest
Thu, Sep 10 - Fri, Sep 11
United Airlines Logo
6:24 am - 11:57 amDSM  Des Moines-STL Lambert-St Louis
5h 33m1 stop Chicago O'Hare Intl
United Airlines Logo
8:00 am - 12:16 pmSTL  Lambert-St Louis-DSM Des Moines
4h 16m1 stop Chicago O'Hare Intl
$227United Airlines
Thu, Sep 10 - Fri, Sep 11
American Airlines Logo
7:58 pm - 12:27 amDSM  Des Moines-STL Lambert-St Louis
4h 29m1 stop Chicago O'Hare Intl
American Airlines Logo
7:27 am - 1:59 pmSTL  Lambert-St Louis-DSM Des Moines
6h 32m1 stop Chicago O'Hare Intl
$235American Airlines
Thu, Sep 10 - Sat, Sep 12
United Airlines Logo
8:00 am - 12:13 pmDSM  Des Moines-STL Lambert-St Louis
4h 13m1 stop Chicago O'Hare Intl
United Airlines Logo
6:50 pm - 10:25 pmSTL  Lambert-St Louis-DSM Des Moines
3h 35m1 stop Chicago O'Hare Intl
$235United Airlines
Thu, Oct 22 - Mon, Oct 26
Southwest Logo
5:40 am - 9:15 amDSM  Des Moines-STL Lambert-St Louis
3h 35m1 stop Chicago Midway
Southwest Logo
2:25 pm - 9:55 pmSTL  Lambert-St Louis-DSM Des Moines
7h 30m1 stop Denver Intl
$235Southwest
Mon, Sep 28 - Mon, Oct 5
Southwest Logo
5:40 am - 6:25 pmDSM  Des Moines-STL Lambert-St Louis
12h 45m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
8:25 am - 11:30 amSTL  Lambert-St Louis-DSM Des Moines
3h 05m1 stop Chicago Midway
$240Southwest
Thu, Sep 10 - Sat, Sep 12
American Airlines Logo
7:49 pm - 12:14 amDSM  Des Moines-STL Lambert-St Louis
4h 25m1 stop Chicago O'Hare Intl
American Airlines Logo
8:07 pm - 12:20 amSTL  Lambert-St Louis-DSM Des Moines
4h 13m1 stop Chicago O'Hare Intl
$266American Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
7:49 pm - 12:14 amDSM  Des Moines-STL Lambert-St Louis
4h 25m1 stop Chicago O'Hare Intl
American Airlines Logo
6:00 am - 10:00 amSTL  Lambert-St Louis-DSM Des Moines
4h 00m1 stop Chicago O'Hare Intl
$266American Airlines
Fri, Sep 4 - Tue, Sep 8
United Airlines Logo
11:32 am - 3:38 pmDSM  Des Moines-STL Lambert-St Louis
4h 06m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 10:30 amSTL  Lambert-St Louis-DSM Des Moines
4h 30m1 stop Chicago O'Hare Intl
$271United Airlines
Wed, Sep 23 - Thu, Sep 24

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Southwest flights from Des Moines to St. Louis

Our best Southwest deals on Des Moines to St. Louis flight tickets
Southwest
Sep 10
DSM5:40 amDes Moines
4h 50m
1 stop
STL10:30 amLambert-St Louis
Sep 11
STL3:15 pmLambert-St Louis
7h 00m
2 stops
DSM10:15 pmDes Moines
$215
Southwest
Sep 10
DSM5:40 amDes Moines
12h 45m
2 stops
STL6:25 pmLambert-St Louis
Sep 11
STL3:45 pmLambert-St Louis
6h 30m
2 stops
DSM10:15 pmDes Moines
$221
Southwest
Sep 10
DSM5:40 amDes Moines
12h 45m
2 stops
STL6:25 pmLambert-St Louis
Sep 12
STL8:25 amLambert-St Louis
3h 05m
1 stop
DSM11:30 amDes Moines
$240

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Sep 18
DSM5:59 pmDes Moines
5h 17m
1 stop
STL11:16 pmLambert-St Louis
Sep 19
STL6:15 amLambert-St Louis
4h 02m
1 stop
DSM10:17 amDes Moines
$280
Delta
Sep 26
DSM10:57 amDes Moines
5h 50m
1 stop
STL4:47 pmLambert-St Louis
Sep 27
STL6:15 amLambert-St Louis
4h 02m
1 stop
DSM10:17 amDes Moines
$326
Delta
Sep 18
DSM5:59 pmDes Moines
5h 17m
1 stop
STL11:16 pmLambert-St Louis
Sep 21
STL8:46 amLambert-St Louis
5h 20m
1 stop
DSM2:06 pmDes Moines
$329

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 9/10

5:40 am-10:30 am

1 stop4h 50m

Lambert-St Louis

Fri 9/11

3:15 pm-10:15 pm

2 stops7h 00m

$215

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 9/10

5:40 am-6:25 pm

2 stops12h 45m

Lambert-St Louis

Fri 9/11

3:45 pm-10:15 pm

2 stops6h 30m

$221

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 9/10

6:24 am-11:57 am

1 stop5h 33m

Lambert-St Louis

Fri 9/11

8:00 am-12:16 pm

1 stop4h 16m

$227

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 9/10

7:58 pm-12:27 am

1 stop4h 29m

Lambert-St Louis

Sat 9/12

7:27 am-1:59 pm

1 stop6h 32m

$235
Quickest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 10/22

8:00 am-12:13 pm

1 stop4h 13m

Lambert-St Louis

Mon 10/26

6:50 pm-10:25 pm

1 stop3h 35m

$235

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Mon 9/28

5:40 am-9:15 am

1 stop3h 35m

Lambert-St Louis

Mon 10/5

2:25 pm-9:55 pm

1 stop7h 30m

$235

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 9/10

5:40 am-6:25 pm

2 stops12h 45m

Lambert-St Louis

Sat 9/12

8:25 am-11:30 am

1 stop3h 05m

$240

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 9/4

7:49 pm-12:14 am

1 stop4h 25m

Lambert-St Louis

Mon 9/7

8:07 pm-12:20 am

1 stop4h 13m

$266

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 9/4

7:49 pm-12:14 am

1 stop4h 25m

Lambert-St Louis

Tue 9/8

6:00 am-10:00 am

1 stop4h 00m

$266

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 9/23

11:32 am-3:38 pm

1 stop4h 06m

Lambert-St Louis

Thu 9/24

6:00 am-10:30 am

1 stop4h 30m

$271

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, November is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. The month of July is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $0.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $357. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $413. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $368 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $404 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to St. Louis flights?

There is only 1 cabin class available to choose from on Des Moines to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$118

Fastest flight time

3h 25m

Direct flights

None
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $118. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $215.
The fastest flight from Des Moines to St. Louis takes 3h 25m
There are no direct flights from Des Moines to St. Louis. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.
Search flight deals

Frequently asked questions about flying from Des Moines to St. Louis

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 3h 25m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $107Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
American AirlinesPriceFrom $158Free CancellationRating
7.1
11,946 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Maryland Heights
St. Peters
Hermann
Collinsville
Florissant
Alton
O'Fallon
Farmington
Clayton
Fenton
Festus
Wentzville
Eureka
Edwardsville
Litchfield
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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