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Cheap flights from Des Moines to St. Louis from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 10/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Southwest Logo
8:35 am - 9:40 amDSM-STL
1h 05mnonstop
Southwest Logo
9:40 pm - 10:50 pmSTL-DSM
1h 10mnonstop
$97Southwest
Find Deal
Sat, Sep 27 - Mon, Sep 29
Southwest Logo
6:10 am - 7:30 amDSM-STL
1h 20mnonstop
Southwest Logo
10:15 am - 11:25 amSTL-DSM
1h 10mnonstop
$137Southwest
Find Deal
Thu, Jan 8 - Mon, Jan 12
American Airlines Logo
11:58 am - 6:11 pmDSM-STL
6h 13m1 stop
American Airlines Logo
2:15 pm - 8:11 pmSTL-DSM
5h 56m1 stop
$159American Airlines
Find Deal
Sat, Oct 25 - Mon, Oct 27
American Airlines Logo
5:42 pm - 11:05 pmDSM-STL
5h 23m1 stop
American Airlines Logo
9:58 am - 4:17 pmSTL-DSM
6h 19m1 stop
$160American Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
Delta Logo
5:44 am - 12:21 pmDSM-STL
6h 37m1 stop
Delta Logo
6:00 am - 10:14 amSTL-DSM
4h 14m1 stop
$177Delta
Find Deal
Sat, Sep 27 - Mon, Sep 29
Delta Logo
5:32 pm - 11:24 pmDSM-STL
5h 52m1 stop
Delta Logo
6:40 am - 5:16 pmSTL-DSM
10h 36m2 stops
$182Delta
Find Deal
Mon, Oct 20 - Mon, Oct 27
United Airlines Logo
11:31 am - 3:44 pmDSM-STL
4h 13m1 stop
United Airlines Logo
5:24 pm - 9:32 pmSTL-DSM
4h 08m1 stop
$217United Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
Frontier Logo
2:37 pm - 9:22 amDSM-STL
18h 45m2 stops
Frontier Logo
8:40 pm - 1:47 pmSTL-DSM
17h 07m1 stop
$261Frontier
Find Deal
Wed, Oct 22 - Wed, Oct 29
Frontier Logo
2:37 pm - 9:22 amDSM-STL
18h 45m2 stops
Frontier Logo
8:40 pm - 1:47 pmSTL-DSM
17h 07m1 stop
$265Frontier
Find Deal
Wed, Oct 22 - Wed, Oct 29
United Airlines Logo
11:30 am - 10:35 pmDSM-STL
11h 05m2 stops
United Airlines Logo
1:35 pm - 8:45 pmSTL-DSM
7h 10m1 stop
$407United Airlines
Find Deal
Wed, Oct 22 - Wed, Oct 29

American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Oct 25
DSM11:58 amDes Moines
6h 13m
1 stop
STL6:11 pmLambert-St Louis
Oct 27
STL2:15 pmLambert-St Louis
5h 56m
1 stop
DSM8:11 pmDes Moines
$159
Find similar
American Airlines
Oct 21
DSM5:42 pmDes Moines
5h 23m
1 stop
STL11:05 pmLambert-St Louis
Oct 28
STL9:58 amLambert-St Louis
6h 19m
1 stop
DSM4:17 pmDes Moines
$160
Find similar
American Airlines
Mar 3
DSM4:27 pmDes Moines
5h 17m
1 stop
STL9:44 pmLambert-St Louis
Mar 4
STL6:04 amLambert-St Louis
4h 59m
1 stop
DSM11:03 amDes Moines
$219
Find similar

United Airlines flights from Des Moines to St. Louis

Our best United Airlines deals on Des Moines to St. Louis flight tickets
United Airlines
Oct 21
DSM11:31 amDes Moines
4h 13m
1 stop
STL3:44 pmLambert-St Louis
Oct 28
STL5:24 pmLambert-St Louis
4h 08m
1 stop
DSM9:32 pmDes Moines
$217
Find similar
United Airlines
Oct 22
DSM11:30 amDes Moines
11h 05m
2 stops
STL10:35 pmLambert-St Louis
Oct 29
STL1:35 pmLambert-St Louis
7h 10m
1 stop
DSM8:45 pmDes Moines
$407
Find similar
United Airlines
Sep 19
DSM1:10 pmDes Moines
10h 34m
2 stops
STL11:44 pmLambert-St Louis
Sep 21
STL8:10 amLambert-St Louis
6h 00m
1 stop
DSM2:10 pmDes Moines
$534
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 8, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/27

8:35 am-9:40 am

Nonstop1h 05m

Lambert-St Louis

Mon 9/29

9:40 pm-10:50 pm

Nonstop1h 10m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/8

6:10 am-7:30 am

Nonstop1h 20m

Lambert-St Louis

Mon 1/12

10:15 am-11:25 am

Nonstop1h 10m

$137

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 10/25

11:58 am-6:11 pm

1 stop6h 13m

Lambert-St Louis

Mon 10/27

2:15 pm-8:11 pm

1 stop5h 56m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/21

5:42 pm-11:05 pm

1 stop5h 23m

Lambert-St Louis

Tue 10/28

9:58 am-4:17 pm

1 stop6h 19m

$160

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/27

5:44 am-12:21 pm

1 stop6h 37m

Lambert-St Louis

Mon 9/29

6:00 am-10:14 am

1 stop4h 14m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/20

5:32 pm-11:24 pm

1 stop5h 52m

Lambert-St Louis

Mon 10/27

6:40 am-5:16 pm

2 stops10h 36m

$182

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 10/21

11:31 am-3:44 pm

1 stop4h 13m

Lambert-St Louis

Tue 10/28

5:24 pm-9:32 pm

1 stop4h 08m

$217

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/22

2:37 pm-9:22 am

2 stops18h 45m

Lambert-St Louis

Wed 10/29

8:40 pm-1:47 pm

1 stop17h 07m

$261

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/22

2:37 pm-9:22 am

2 stops18h 45m

Lambert-St Louis

Wed 10/29

8:40 pm-1:47 pm

1 stop17h 07m

$265

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/22

11:30 am-10:35 pm

2 stops11h 05m

Lambert-St Louis

Wed 10/29

1:35 pm-8:45 pm

1 stop7h 10m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $182. The month of August is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $249.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $377. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $433. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $399 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $412 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

As of September 2025, prices for Des Moines to St. Louis flights are approximately 85% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$163

Fastest flight time

1h 05m

Direct flights

Mon, Tue, Wed, Thu, Fri and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $163. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $283.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Monday, Tuesday, Wednesday, Thursday, Friday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $97. Generally, Southwest has 9 flights on this route every week with an average price of $309. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Farmington
Festus
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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