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Cheap flights from Des Moines to St. Louis from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 8/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

American Airlines Logo
5:14 pm - 11:51 pmDSM-STL
6h 37m1 stop
American Airlines Logo
8:50 am - 3:24 pmSTL-DSM
6h 34m1 stop
$157American Airlines
Find Deal
Thu, Aug 28 - Thu, Sep 4
American Airlines Logo
8:17 am - 1:51 pmDSM-STL
5h 34m1 stop
American Airlines Logo
9:56 am - 3:33 pmSTL-DSM
5h 37m1 stop
$159American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
4:09 pm - 10:50 pmDSM-STL
6h 41m1 stop
American Airlines Logo
8:03 pm - 11:28 pmSTL-DSM
3h 25m1 stop
$167American Airlines
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Fri, Sep 5 - Sun, Sep 7
Delta Logo
10:18 am - 4:45 pmDSM-STL
6h 27m1 stop
Delta Logo
10:45 am - 8:59 pmSTL-DSM
10h 14m2 stops
$172Delta
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Wed, Aug 27 - Wed, Sep 3
Southwest Logo
5:30 pm - 6:35 pmDSM-STL
1h 05mnonstop
Southwest Logo
10:10 am - 11:20 amSTL-DSM
1h 10mnonstop
$203Southwest
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Thu, Sep 18 - Sun, Sep 21
Delta Logo
6:30 pm - 11:14 pmDSM-STL
4h 44m1 stop
Delta Logo
2:15 pm - 8:30 pmSTL-DSM
6h 15m1 stop
$208Delta
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Mon, Aug 11 - Fri, Aug 15
Delta Logo
11:23 am - 4:06 pmDSM-STL
4h 43m1 stop
Delta Logo
6:40 am - 5:12 pmSTL-DSM
10h 32m2 stops
$213Delta
Find Deal
Thu, Aug 28 - Thu, Sep 4
Southwest Logo
6:00 am - 7:05 amDSM-STL
1h 05mnonstop
Southwest Logo
1:55 pm - 3:00 pmSTL-DSM
1h 05mnonstop
$214Southwest
Find Deal
Mon, Aug 11 - Sat, Aug 16
Frontier Logo
3:30 pm - 8:52 amDSM-STL
17h 22m2 stops
Frontier Logo
7:52 pm - 7:59 pmSTL-DSM
24h 07m1 stop
$294Frontier
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Wed, Oct 22 - Sun, Oct 26
United Airlines Logo
5:12 pm - 3:47 pmDSM-STL
22h 35m2 stops
United Airlines Logo
5:00 am - 10:29 amSTL-DSM
5h 29m1 stop
$421United Airlines
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Mon, Aug 11 - Fri, Aug 15

Southwest flights from Des Moines to St. Louis

Our best Southwest deals on Des Moines to St. Louis flight tickets
Southwest
Sep 18
DSM5:30 pmDes Moines
1h 05m
STL6:35 pmLambert-St Louis
Sep 21
STL10:10 amLambert-St Louis
1h 10m
DSM11:20 amDes Moines
$203
Find similar
Southwest
Aug 11
DSM6:00 amDes Moines
1h 05m
STL7:05 amLambert-St Louis
Aug 16
STL1:55 pmLambert-St Louis
1h 05m
DSM3:00 pmDes Moines
$214
Find similar
Southwest
Aug 16
DSM6:10 amDes Moines
10h 50m
1 stop
STL5:00 pmLambert-St Louis
Aug 18
STL10:00 amLambert-St Louis
1h 05m
DSM11:05 amDes Moines
$220
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American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Aug 28
DSM5:14 pmDes Moines
6h 37m
1 stop
STL11:51 pmLambert-St Louis
Sep 4
STL8:50 amLambert-St Louis
6h 34m
1 stop
DSM3:24 pmDes Moines
$157
Find similar
American Airlines
Aug 27
DSM8:17 amDes Moines
5h 34m
1 stop
STL1:51 pmLambert-St Louis
Sep 3
STL9:56 amLambert-St Louis
5h 37m
1 stop
DSM3:33 pmDes Moines
$159
Find similar
American Airlines
Sep 5
DSM4:09 pmDes Moines
6h 41m
1 stop
STL10:50 pmLambert-St Louis
Sep 7
STL8:03 pmLambert-St Louis
3h 25m
1 stop
DSM11:28 pmDes Moines
$167
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $257. The month of June is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $291.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $381. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $435. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $401 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $414 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There are 1 cabin classes available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Des Moines to St. Louis.

How have Des Moines to St. Louis flight prices changed over time?

As of July 2025, prices for Des Moines to St. Louis flights are approximately 76% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$49

Fastest flight time

1h 05m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $49. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $157.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
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  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?

Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,863 reviews
Search United Airlines flights

  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $97. Generally, Southwest has 10 flights on this route every week with an average price of $310. Southwest is rated 8.0/10 by our users.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
Collinsville
Fenton
O'Fallon
Farmington
Alton
St. Peters
Wentzville
Festus
Glencoe
Clayton
Edwardsville
Eureka
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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