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Cheap flights from Des Moines to Louisville from $137

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:32 am - 4:38 pm
DSM
-
SDF
4h 06m
1 stop
United Airlines Logo
10:23 am - 2:16 pm
SDF
-
DSM
4h 53m
1 stop
$265United Airlines
Wed, Aug 26 - Sat, Aug 29
Southwest Logo
6:10 am - 4:20 pm
DSM
-
SDF
9h 10m
2 stops
Southwest Logo
8:45 am - 11:50 am
SDF
-
DSM
4h 05m
1 stop
$270Southwest
Tue, Aug 11 - Tue, Aug 18
United Airlines Logo
1:24 pm - 8:31 pm
DSM
-
SDF
6h 07m
1 stop
United Airlines Logo
5:15 am - 10:31 am
SDF
-
DSM
6h 16m
1 stop
$273United Airlines
Wed, Oct 21 - Sat, Oct 24
Southwest Logo
6:10 am - 4:20 pm
DSM
-
SDF
9h 10m
2 stops
Southwest Logo
5:30 am - 11:50 am
SDF
-
DSM
7h 20m
2 stops
$275Southwest
Tue, Aug 11 - Tue, Aug 18
Southwest Logo
5:35 am - 10:00 am
DSM
-
SDF
3h 25m
1 stop
Southwest Logo
11:20 am - 8:35 pm
SDF
-
DSM
10h 15m
2 stops
$278Southwest
Wed, Oct 21 - Sat, Oct 24
Southwest Logo
6:10 am - 4:20 pm
DSM
-
SDF
9h 10m
2 stops
Southwest Logo
8:20 am - 7:25 pm
SDF
-
DSM
12h 05m
2 stops
$281Southwest
Wed, Aug 26 - Sat, Aug 29
Southwest Logo
5:35 am - 5:20 pm
DSM
-
SDF
10h 45m
2 stops
Southwest Logo
11:20 am - 8:35 pm
SDF
-
DSM
10h 15m
2 stops
$289Southwest
Wed, Oct 21 - Sat, Oct 24
Delta Logo
6:37 pm - 12:26 am
DSM
-
SDF
4h 49m
1 stop
Delta Logo
6:49 am - 10:13 am
SDF
-
DSM
4h 24m
1 stop
$310Delta
Tue, Jul 28 - Fri, Jul 31
Southwest Logo
6:10 am - 11:20 am
DSM
-
SDF
4h 10m
1 stop
Southwest Logo
3:20 pm - 10:10 pm
SDF
-
DSM
7h 50m
2 stops
$315Southwest
Tue, Sep 22 - Fri, Sep 25
Delta Logo
5:56 pm - 11:56 pm
DSM
-
SDF
5h 00m
1 stop
Delta Logo
2:34 pm - 8:39 pm
SDF
-
DSM
7h 05m
1 stop
$318Delta
Fri, Aug 14 - Mon, Aug 17

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Southwest flights from Des Moines to Louisville

Our best Southwest deals on Des Moines to Louisville flight tickets
Southwest
Aug 11
DSM2:40 pmDes Moines
4h 55m
1 stop
SDF8:35 pmLouisville Intl
Aug 18
SDF8:45 amLouisville Intl
4h 05m
1 stop
DSM11:50 amDes Moines
$265
Southwest
Aug 11
DSM6:10 amDes Moines
9h 10m
2 stops
SDF4:20 pmLouisville Intl
Aug 18
SDF8:45 amLouisville Intl
4h 05m
1 stop
DSM11:50 amDes Moines
$270
Southwest
Aug 11
DSM6:10 amDes Moines
9h 10m
2 stops
SDF4:20 pmLouisville Intl
Aug 18
SDF5:30 amLouisville Intl
7h 20m
2 stops
DSM11:50 amDes Moines
$275

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Jul 28
DSM6:37 pmDes Moines
4h 49m
1 stop
SDF12:26 amLouisville Intl
Jul 31
SDF6:49 amLouisville Intl
4h 24m
1 stop
DSM10:13 amDes Moines
$310
Delta
Aug 14
DSM5:56 pmDes Moines
5h 00m
1 stop
SDF11:56 pmLouisville Intl
Aug 17
SDF2:34 pmLouisville Intl
7h 05m
1 stop
DSM8:39 pmDes Moines
$318
Delta
Jul 14
DSM6:37 pmDes Moines
4h 49m
1 stop
SDF12:26 amLouisville Intl
Jul 17
SDF4:47 pmLouisville Intl
6h 42m
1 stop
DSM10:29 pmDes Moines
$330

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 28, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 8/26

11:32 am-4:38 pm

1 stop4h 06m

Louisville Intl

Sat 8/29

10:23 am-2:16 pm

1 stop4h 53m

$265

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 8/11

6:10 am-4:20 pm

2 stops9h 10m

Louisville Intl

Tue 8/18

8:45 am-11:50 am

1 stop4h 05m

$270

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/21

1:24 pm-8:31 pm

1 stop6h 07m

Louisville Intl

Sat 10/24

5:15 am-10:31 am

1 stop6h 16m

$273

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 8/11

6:10 am-4:20 pm

2 stops9h 10m

Louisville Intl

Tue 8/18

5:30 am-11:50 am

2 stops7h 20m

$275

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/21

5:35 am-10:00 am

1 stop3h 25m

Louisville Intl

Sat 10/24

11:20 am-8:35 pm

2 stops10h 15m

$278

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 8/26

6:10 am-4:20 pm

2 stops9h 10m

Louisville Intl

Sat 8/29

8:20 am-7:25 pm

2 stops12h 05m

$281

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/21

5:35 am-5:20 pm

2 stops10h 45m

Louisville Intl

Sat 10/24

11:20 am-8:35 pm

2 stops10h 15m

$289

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 7/28

6:37 pm-12:26 am

1 stop4h 49m

Louisville Intl

Fri 7/31

6:49 am-10:13 am

1 stop4h 24m

$310

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 9/22

6:10 am-11:20 am

1 stop4h 10m

Louisville Intl

Fri 9/25

3:20 pm-10:10 pm

2 stops7h 50m

$315

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 8/14

5:56 pm-11:56 pm

1 stop5h 00m

Louisville Intl

Mon 8/17

2:34 pm-8:39 pm

1 stop7h 05m

$318

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of January, then departing from Des Moines during the month October is also very affordable. Most momondo users find prices during this month for around $298.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 16% on your flight if you consider stops on a Des Moines to Louisville flight.

How have Des Moines to Louisville flight prices changed over time?

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 3h 45m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

Frequently asked questions about flying from Des Moines to Louisville

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 45m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $109Free CancellationRating
7.4
9,899 reviews
Search United Airlines flights
DeltaPriceFrom $129Free CancellationRating
7.8
8,455 reviews
Search Delta flights
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,776 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
Shepherdsville
New Albany
Elizabeth
Charlestown
Corydon
Brandenburg
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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