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Cheap flights from Des Moines to Louisville from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 5/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
4:20 pm - 9:55 pm
DSM
-
SDF
4h 35m
1 stop
Southwest Logo
7:15 pm - 10:10 pm
SDF
-
DSM
3h 55m
1 stop
$264Southwest
Mon, Mar 30 - Tue, Apr 7
Southwest Logo
4:20 pm - 9:55 pm
DSM
-
SDF
4h 35m
1 stop
Southwest Logo
3:45 pm - 10:10 pm
SDF
-
DSM
7h 25m
2 stops
$269Southwest
Mon, Mar 30 - Tue, Apr 7
American Airlines Logo
5:00 am - 11:30 am
DSM
-
SDF
5h 30m
1 stop
American Airlines Logo
6:12 pm - 10:19 pm
SDF
-
DSM
5h 07m
1 stop
$302American Airlines
Thu, Feb 26 - Sun, Mar 1
Southwest Logo
5:35 am - 3:50 pm
DSM
-
SDF
9h 15m
2 stops
Southwest Logo
3:45 pm - 10:10 pm
SDF
-
DSM
7h 25m
2 stops
$321Southwest
Mon, Mar 30 - Tue, Apr 7
Delta Logo
6:30 pm - 11:59 pm
DSM
-
SDF
4h 29m
1 stop
Delta Logo
6:00 am - 10:16 am
SDF
-
DSM
5h 16m
1 stop
$327Delta
Fri, May 8 - Sun, May 10
United Airlines Logo
1:05 pm - 6:36 pm
DSM
-
SDF
4h 31m
1 stop
United Airlines Logo
7:15 am - 10:37 am
SDF
-
DSM
4h 22m
1 stop
$328United Airlines
Wed, May 13 - Sun, May 17
Southwest Logo
5:25 am - 9:55 am
DSM
-
SDF
3h 30m
1 stop
Southwest Logo
2:40 pm - 11:05 pm
SDF
-
DSM
9h 25m
1 stop
$352Southwest
Thu, May 21 - Mon, May 25
Southwest Logo
5:30 am - 2:45 pm
DSM
-
SDF
8h 15m
2 stops
Southwest Logo
8:30 am - 11:30 am
SDF
-
DSM
4h 00m
1 stop
$377Southwest
Wed, May 13 - Sun, May 17
United Airlines Logo
1:29 pm - 10:37 pm
DSM
-
SDF
8h 08m
1 stop
United Airlines Logo
9:00 am - 4:22 pm
SDF
-
DSM
8h 22m
1 stop
$389United Airlines
Sat, Feb 14 - Wed, Feb 18
Southwest Logo
6:15 pm - 12:05 am
DSM
-
SDF
4h 50m
2 stops
Southwest Logo
1:40 pm - 11:35 pm
SDF
-
DSM
10h 55m
2 stops
$403Southwest
Thu, Feb 26 - Sun, Mar 1

Southwest flights from Des Moines to Louisville

Our best Southwest deals on Des Moines to Louisville flight tickets
Southwest
Mar 30
DSM4:20 pmDes Moines
4h 35m
1 stop
SDF9:55 pmLouisville Intl
Apr 7
SDF7:15 pmLouisville Intl
3h 55m
1 stop
DSM10:10 pmDes Moines
$264
Southwest
Mar 30
DSM4:20 pmDes Moines
4h 35m
1 stop
SDF9:55 pmLouisville Intl
Apr 7
SDF3:45 pmLouisville Intl
7h 25m
2 stops
DSM10:10 pmDes Moines
$269
Southwest
Mar 30
DSM5:35 amDes Moines
9h 15m
2 stops
SDF3:50 pmLouisville Intl
Apr 7
SDF3:45 pmLouisville Intl
7h 25m
2 stops
DSM10:10 pmDes Moines
$321

United Airlines flights from Des Moines to Louisville

Our best United Airlines deals on Des Moines to Louisville flight tickets
United Airlines
May 13
DSM1:05 pmDes Moines
4h 31m
1 stop
SDF6:36 pmLouisville Intl
May 17
SDF7:15 amLouisville Intl
4h 22m
1 stop
DSM10:37 amDes Moines
$328
United Airlines
Feb 14
DSM3:24 pmDes Moines
3h 45m
1 stop
SDF8:09 pmLouisville Intl
Feb 18
SDF9:00 amLouisville Intl
6h 27m
1 stop
DSM2:27 pmDes Moines
$389
United Airlines
Feb 14
DSM3:24 pmDes Moines
22h 23m
2 stops
SDF2:47 pmLouisville Intl
Feb 18
SDF9:00 amLouisville Intl
8h 22m
1 stop
DSM4:22 pmDes Moines
$466

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 3/30

4:20 pm-9:55 pm

1 stop4h 35m

Louisville Intl

Tue 4/7

7:15 pm-10:10 pm

1 stop3h 55m

$264

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 3/30

4:20 pm-9:55 pm

1 stop4h 35m

Louisville Intl

Tue 4/7

3:45 pm-10:10 pm

2 stops7h 25m

$269

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 2/26

5:00 am-11:30 am

1 stop5h 30m

Louisville Intl

Sun 3/1

6:12 pm-10:19 pm

1 stop5h 07m

$302

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 3/30

5:35 am-3:50 pm

2 stops9h 15m

Louisville Intl

Tue 4/7

3:45 pm-10:10 pm

2 stops7h 25m

$321

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 5/8

6:30 pm-11:59 pm

1 stop4h 29m

Louisville Intl

Sun 5/10

6:00 am-10:16 am

1 stop5h 16m

$327

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 5/13

1:05 pm-6:36 pm

1 stop4h 31m

Louisville Intl

Sun 5/17

7:15 am-10:37 am

1 stop4h 22m

$328

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 5/21

5:25 am-9:55 am

1 stop3h 30m

Louisville Intl

Mon 5/25

2:40 pm-11:05 pm

1 stop9h 25m

$352

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 5/13

5:30 am-2:45 pm

2 stops8h 15m

Louisville Intl

Sun 5/17

8:30 am-11:30 am

1 stop4h 00m

$377

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 2/14

1:29 pm-10:37 pm

1 stop8h 08m

Louisville Intl

Wed 2/18

9:00 am-4:22 pm

1 stop8h 22m

$389

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 2/26

6:15 pm-12:05 am

2 stops4h 50m

Louisville Intl

Sun 3/1

1:40 pm-11:35 pm

2 stops10h 55m

$403

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of March, then departing from Des Moines during the month January is also very affordable. Most momondo users find prices during this month for around $276.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to Louisville flight.

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 3h 45m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 45m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $129Free CancellationRating
7.9
8,128 reviews
Search Delta flights
United AirlinesPriceFrom $148Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights
American AirlinesPriceFrom $260Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Corydon
Elizabeth
Charlestown
Brandenburg
Springfield
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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