Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Louisville from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:05 am - 1:43 pmDSM  Des Moines-SDF Louisville Intl
5h 38m1 stop Chicago O'Hare Intl
American Airlines Logo
10:29 am - 1:59 pmSDF  Louisville Intl-DSM Des Moines
4h 30m1 stop Chicago O'Hare Intl
$233American Airlines
Sat, Sep 12 - Tue, Sep 15
Delta Logo
5:59 pm - 11:43 pmDSM  Des Moines-SDF Louisville Intl
4h 44m1 stop Minneapolis St Paul
Delta Logo
9:45 am - 1:49 pmSDF  Louisville Intl-DSM Des Moines
5h 04m1 stop Atlanta Hartsfield-Jackson
$233Delta
Tue, Sep 15 - Thu, Sep 17
United Airlines Logo
11:23 am - 5:02 pmDSM  Des Moines-SDF Louisville Intl
4h 39m1 stop Chicago O'Hare Intl
United Airlines Logo
2:15 pm - 5:33 pmSDF  Louisville Intl-DSM Des Moines
4h 18m1 stop Chicago O'Hare Intl
$233United Airlines
Wed, Nov 11 - Sat, Nov 14
Delta Logo
6:54 pm - 11:59 pmDSM  Des Moines-SDF Louisville Intl
4h 05m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:00 am - 10:11 amSDF  Louisville Intl-DSM Des Moines
4h 11m1 stop Minneapolis St Paul
$233Delta
Tue, Oct 27 - Sat, Oct 31
Delta Logo
11:31 am - 7:30 pmDSM  Des Moines-SDF Louisville Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:09 am - 1:49 pmSDF  Louisville Intl-DSM Des Moines
6h 40m1 stop Atlanta Hartsfield-Jackson
$233Delta
Thu, Sep 10 - Wed, Sep 16
Southwest Logo
5:40 am - 10:25 amDSM  Des Moines-SDF Louisville Intl
3h 45m1 stop Chicago Midway
Southwest Logo
5:30 am - 11:50 amSDF  Louisville Intl-DSM Des Moines
7h 20m2 stops Baltimore/Washington Chicago Midway
$238Southwest
Thu, Sep 10 - Wed, Sep 16
Southwest Logo
5:30 am - 10:10 amDSM  Des Moines-SDF Louisville Intl
3h 40m1 stop Chicago Midway
Southwest Logo
1:15 pm - 9:05 pmSDF  Louisville Intl-DSM Des Moines
8h 50m2 stops Chicago Midway Denver Intl
$238Southwest
Sat, Sep 12 - Tue, Sep 15
United Airlines Logo
6:00 am - 1:11 pmDSM  Des Moines-SDF Louisville Intl
6h 11m1 stop Chicago O'Hare Intl
United Airlines Logo
5:45 pm - 9:23 pmSDF  Louisville Intl-DSM Des Moines
4h 38m1 stop Chicago O'Hare Intl
$257United Airlines
Wed, Sep 2 - Wed, Sep 2
American Airlines Logo
1:55 pm - 9:25 pmDSM  Des Moines-SDF Louisville Intl
6h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
6:45 pm - 12:20 amSDF  Louisville Intl-DSM Des Moines
6h 35m1 stop Chicago O'Hare Intl
$268American Airlines
Wed, Sep 2 - Sun, Sep 6
American Airlines Logo
1:55 pm - 9:25 pmDSM  Des Moines-SDF Louisville Intl
6h 30m1 stop Chicago O'Hare Intl
American Airlines Logo
6:28 am - 10:00 amSDF  Louisville Intl-DSM Des Moines
4h 32m1 stop Chicago O'Hare Intl
$279American Airlines
Tue, Aug 25 - Sat, Aug 29

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Oct 13
DSM6:54 pmDes Moines
4h 05m
1 stop
SDF11:59 pmLouisville Intl
Oct 24
SDF7:00 amLouisville Intl
4h 11m
1 stop
DSM10:11 amDes Moines
$233
Delta
Sep 1
DSM11:28 amDes Moines
7h 05m
1 stop
SDF7:33 pmLouisville Intl
Sep 8
SDF6:00 pmLouisville Intl
5h 26m
1 stop
DSM10:26 pmDes Moines
$257
Delta
Nov 16
DSM2:43 pmDes Moines
7h 03m
1 stop
SDF10:46 pmLouisville Intl
Nov 21
SDF7:00 amLouisville Intl
4h 43m
1 stop
DSM10:43 amDes Moines
$295

Southwest flights from Des Moines to Louisville

Our best Southwest deals on Des Moines to Louisville flight tickets
Southwest
Sep 10
DSM5:40 amDes Moines
3h 45m
1 stop
SDF10:25 amLouisville Intl
Sep 16
SDF5:30 amLouisville Intl
7h 20m
2 stops
DSM11:50 amDes Moines
$238
Southwest
Oct 13
DSM3:00 pmDes Moines
4h 10m
1 stop
SDF8:10 pmLouisville Intl
Oct 24
SDF7:05 amLouisville Intl
5h 55m
2 stops
DSM12:00 pmDes Moines
$239
Southwest
Sep 12
DSM5:30 amDes Moines
14h 55m
2 stops
SDF9:25 pmLouisville Intl
Sep 15
SDF1:15 pmLouisville Intl
8h 50m
2 stops
DSM9:05 pmDes Moines
$249

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Sat 9/12

7:05 am-1:43 pm

1 stop5h 38m

Louisville Intl

Tue 9/15

10:29 am-1:59 pm

1 stop4h 30m

$233

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Tue 9/15

5:59 pm-11:43 pm

1 stop4h 44m

Louisville Intl

Thu 9/17

9:45 am-1:49 pm

1 stop5h 04m

$233

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Wed 11/11

11:23 am-5:02 pm

1 stop4h 39m

Louisville Intl

Sat 11/14

2:15 pm-5:33 pm

1 stop4h 18m

$233
Quickest round-trip

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Tue 10/27

6:54 pm-11:59 pm

1 stop4h 05m

Louisville Intl

Sat 10/31

7:00 am-10:11 am

1 stop4h 11m

$233

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Thu 9/10

11:31 am-7:30 pm

1 stop6h 59m

Louisville Intl

Wed 9/16

8:09 am-1:49 pm

1 stop6h 40m

$233

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Thu 9/10

5:40 am-10:25 am

1 stop3h 45m

Louisville Intl

Wed 9/16

5:30 am-11:50 am

2 stops7h 20m

$238

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Sat 9/12

5:30 am-10:10 am

1 stop3h 40m

Louisville Intl

Tue 9/15

1:15 pm-9:05 pm

2 stops8h 50m

$238

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Wed 9/2

6:00 am-1:11 pm

1 stop6h 11m

Louisville Intl

Wed 9/2

5:45 pm-9:23 pm

1 stop4h 38m

$257

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Wed 9/2

1:55 pm-9:25 pm

1 stop6h 30m

Louisville Intl

Sun 9/6

6:45 pm-12:20 am

1 stop6h 35m

$268

Des MoinesLouisville

DSM Des Moines - SDF Louisville Intl

DSMSDF

Des Moines

Tue 8/25

1:55 pm-9:25 pm

1 stop6h 30m

Louisville Intl

Sat 8/29

6:28 am-10:00 am

1 stop4h 32m

$279

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Louisville?

Prices are currently low for flights on this route.

Typical prices usually range from $305 to $466.
The lowest price recently found on this route was $233.

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of January, then departing from Des Moines during the month October is also very affordable. Most momondo users find prices during this month for around $367.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 16% on your flight if you consider stops on a Des Moines to Louisville flight.

How have Des Moines to Louisville flight prices changed over time?

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

3h 30m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 3h 30m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

Frequently asked questions about flying from Des Moines to Louisville

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 30m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,913 reviews
Search American Airlines flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights
DeltaPriceFrom $288Free CancellationRating
7.8
8,505 reviews
Search Delta flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
New Albany
Shepherdsville
Elizabeth
Charlestown
Corydon
Brandenburg
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

An easier way to manage your Louisville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 9/11
Fri 9/18
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States