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Cheap flights from Des Moines to Louisville from $204

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:16 pm - 11:50 pm
DSM
-
SDF
5h 34m1 stop
Delta Logo
6:23 am - 10:51 am
SDF
-
DSM
5h 28m1 stop
$251Delta
Wed, Jan 21 - Wed, Jan 28
American Airlines Logo
11:42 am - 10:12 pm
DSM
-
SDF
9h 30m2 stops
American Airlines Logo
7:40 am - 3:15 pm
SDF
-
DSM
8h 35m1 stop
$257American Airlines
Wed, Jan 21 - Wed, Jan 28
American Airlines Logo
11:42 am - 9:16 pm
DSM
-
SDF
8h 34m2 stops
American Airlines Logo
7:00 am - 3:45 pm
SDF
-
DSM
9h 45m2 stops
$262American Airlines
Wed, Jan 21 - Wed, Jan 28
American Airlines Logo
7:00 am - 12:32 pm
DSM
-
SDF
4h 32m1 stop
American Airlines Logo
6:32 am - 9:39 am
SDF
-
DSM
4h 07m1 stop
$327American Airlines
Sun, Feb 8 - Sun, Feb 15
American Airlines Logo
11:42 am - 10:12 pm
DSM
-
SDF
9h 30m2 stops
American Airlines Logo
12:00 pm - 5:57 pm
SDF
-
DSM
6h 57m1 stop
$332American Airlines
Sun, Feb 8 - Sun, Feb 15
American Airlines Logo
11:42 am - 10:12 pm
DSM
-
SDF
9h 30m2 stops
American Airlines Logo
10:00 am - 5:57 pm
SDF
-
DSM
8h 57m2 stops
$337American Airlines
Sun, Feb 8 - Sun, Feb 15
Multiple Airlines Logo
8:05 am - 11:59 pm
DSM
-
SDF
38h 54m2 stops
Multiple Airlines Logo
9:21 pm - 9:13 pm
SDF
-
DSM
24h 52m1 stop
$391Multiple Airlines
Fri, Dec 19 - Sun, Dec 21
Delta Logo
11:02 am - 3:46 pm
DSM
-
SDF
3h 44m1 stop
Delta Logo
6:40 am - 10:22 am
SDF
-
DSM
4h 42m1 stop
$393Delta
Fri, Mar 13 - Sun, Mar 15
United Airlines Logo
8:00 am - 1:13 pm
DSM
-
SDF
4h 13m1 stop
United Airlines Logo
2:00 pm - 6:05 pm
SDF
-
DSM
5h 05m1 stop
$407United Airlines
Mon, Dec 22 - Fri, Dec 26
Delta Logo
6:50 am - 11:57 am
DSM
-
SDF
4h 07m1 stop
Delta Logo
12:21 pm - 5:15 pm
SDF
-
DSM
5h 54m1 stop
$452Delta
Fri, Dec 19 - Sun, Dec 21

American Airlines flights from Des Moines to Louisville

Our best American Airlines deals on Des Moines to Louisville flight tickets
American Airlines
Jan 21
DSM11:42 amDes Moines
9h 30m
2 stops
SDF10:12 pmLouisville Intl
Jan 28
SDF7:40 amLouisville Intl
8h 35m
1 stop
DSM3:15 pmDes Moines
$257
Find similar
American Airlines
Jan 21
DSM11:42 amDes Moines
8h 34m
2 stops
SDF9:16 pmLouisville Intl
Jan 28
SDF7:00 amLouisville Intl
9h 45m
2 stops
DSM3:45 pmDes Moines
$262
Find similar
American Airlines
Feb 8
DSM7:00 amDes Moines
4h 32m
1 stop
SDF12:32 pmLouisville Intl
Feb 15
SDF6:32 amLouisville Intl
4h 07m
1 stop
DSM9:39 amDes Moines
$327
Find similar

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Jan 21
DSM5:16 pmDes Moines
5h 34m
1 stop
SDF11:50 pmLouisville Intl
Jan 28
SDF6:23 amLouisville Intl
5h 28m
1 stop
DSM10:51 amDes Moines
$251
Find similar
Delta
Dec 19
DSM6:50 amDes Moines
4h 07m
1 stop
SDF11:57 amLouisville Intl
Dec 21
SDF12:21 pmLouisville Intl
5h 54m
1 stop
DSM5:15 pmDes Moines
$452
Find similar
Delta
Dec 13
DSM3:00 pmDes Moines
5h 31m
1 stop
SDF9:31 pmLouisville Intl
Dec 17
SDF12:58 pmLouisville Intl
5h 49m
1 stop
DSM5:47 pmDes Moines
$497
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 1/21

5:16 pm-11:50 pm

1 stop5h 34m

Louisville Intl

Wed 1/28

6:23 am-10:51 am

1 stop5h 28m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 1/21

11:42 am-10:12 pm

2 stops9h 30m

Louisville Intl

Wed 1/28

7:40 am-3:15 pm

1 stop8h 35m

$257

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 1/21

11:42 am-9:16 pm

2 stops8h 34m

Louisville Intl

Wed 1/28

7:00 am-3:45 pm

2 stops9h 45m

$262

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 2/8

7:00 am-12:32 pm

1 stop4h 32m

Louisville Intl

Sun 2/15

6:32 am-9:39 am

1 stop4h 07m

$327

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 2/8

11:42 am-10:12 pm

2 stops9h 30m

Louisville Intl

Sun 2/15

12:00 pm-5:57 pm

1 stop6h 57m

$332

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sun 2/8

11:42 am-10:12 pm

2 stops9h 30m

Louisville Intl

Sun 2/15

10:00 am-5:57 pm

2 stops8h 57m

$337

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 12/19

8:05 am-11:59 pm

2 stops38h 54m

Louisville Intl

Sun 12/21

9:21 pm-9:13 pm

1 stop24h 52m

$391

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 3/13

11:02 am-3:46 pm

1 stop3h 44m

Louisville Intl

Sun 3/15

6:40 am-10:22 am

1 stop4h 42m

$393

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 12/22

8:00 am-1:13 pm

1 stop4h 13m

Louisville Intl

Fri 12/26

2:00 pm-6:05 pm

1 stop5h 05m

$407

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 12/19

6:50 am-11:57 am

1 stop4h 07m

Louisville Intl

Sun 12/21

12:21 pm-5:15 pm

1 stop5h 54m

$452

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of October, then departing from Des Moines during the month February is also very affordable. Most momondo users find prices during this month for around $308.

What is the cheapest day to depart on your flight to Louisville?

On average, the least expensive day to fly to Louisville from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $333. However, this price may fluctuate depending on the airline, the season, and holidays. Flights from Des Moines to Louisville on a Sunday will generally be more expensive and average around $457. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Louisville?

Our data shows that the cheapest Des Moines to Louisville flights are usually those with departure times at noon. Our users have found flights to Louisville at noon for as low as $322. In the morning is when there is more demand to fly to Louisville, so prices are often more expensive at around $396 per ticket.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 28% on your flight if you consider stops on a Des Moines to Louisville flight.

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

3h 44m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 3h 44m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 4h 07m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $148Free CancellationRating
7.4
9,076 reviews
Search United Airlines flights
DeltaPriceFrom $196Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Corydon
Elizabeth
Charlestown
Springfield
Brandenburg
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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