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Cheap flights from Des Moines to Louisville from $114

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 9/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville (DSM-SDF)

Cheap round-trip flights

Delta Logo
2:13 pm - 7:11 pmDSM-SDF
3h 58m1 stop
Delta Logo
7:09 am - 1:28 pmSDF-DSM
7h 19m1 stop
$237Delta
Find Deal
Wed, Oct 8 - Wed, Oct 15
American Airlines Logo
6:09 pm - 11:03 pmDSM-SDF
3h 54m1 stop
American Airlines Logo
7:35 am - 1:05 pmSDF-DSM
6h 30m1 stop
$247American Airlines
Find Deal
Mon, Sep 22 - Thu, Sep 25
Logo
7:30 am - 2:02 pmDSM-SDF
29h 32m1 stop
Logo
5:31 pm - 7:57 pmSDF-DSM
27h 26m2 stops
$296
Find Deal
Wed, Oct 8 - Wed, Oct 15
American Airlines Logo
3:48 pm - 10:25 pmDSM-SDF
5h 37m1 stop
American Airlines Logo
5:25 am - 12:31 pmSDF-DSM
8h 06m1 stop
$297American Airlines
Find Deal
Fri, Oct 31 - Sun, Nov 2
Southwest Logo
6:20 am - 6:05 pmDSM-SDF
10h 45m2 stops
Southwest Logo
1:45 pm - 9:50 pmSDF-DSM
9h 05m2 stops
$307Southwest
Find Deal
Tue, Oct 21 - Wed, Oct 22
Southwest Logo
10:15 am - 11:35 pmDSM-SDF
12h 20m1 stop
Southwest Logo
3:50 pm - 9:50 pmSDF-DSM
7h 00m2 stops
$308Southwest
Find Deal
Tue, Oct 21 - Wed, Oct 22
American Airlines Logo
7:30 am - 6:37 pmDSM-SDF
10h 07m2 stops
American Airlines Logo
5:25 am - 12:31 pmSDF-DSM
8h 06m1 stop
$342American Airlines
Find Deal
Fri, Oct 31 - Sun, Nov 2
Delta Logo
3:50 pm - 10:42 pmDSM-SDF
5h 52m1 stop
Delta Logo
12:48 pm - 4:22 pmSDF-DSM
4h 34m1 stop
$367Delta
Find Deal
Tue, Sep 9 - Sat, Sep 13
United Airlines Logo
6:15 am - 1:30 pmDSM-SDF
6h 15m1 stop
United Airlines Logo
5:52 pm - 9:45 pmSDF-DSM
4h 53m1 stop
$427United Airlines
Find Deal
Wed, Sep 10 - Mon, Sep 15
United Airlines Logo
3:25 pm - 8:28 pmDSM-SDF
4h 03m1 stop
United Airlines Logo
1:40 pm - 9:45 pmSDF-DSM
9h 05m2 stops
$448United Airlines
Find Deal
Wed, Sep 10 - Mon, Sep 15

American Airlines flights from Des Moines to Louisville

Our best American Airlines deals on Des Moines to Louisville flight tickets
American Airlines
Sep 3
DSM7:03 amDes Moines
8h 45m
2 stops
SDF4:48 pmLouisville Intl
Sep 5
SDF1:09 pmLouisville Intl
4h 40m
1 stop
DSM4:49 pmDes Moines
$232
Find similar
American Airlines
Sep 22
DSM6:09 pmDes Moines
3h 54m
1 stop
SDF11:03 pmLouisville Intl
Sep 25
SDF7:35 amLouisville Intl
6h 30m
1 stop
DSM1:05 pmDes Moines
$247
Find similar
American Airlines
Oct 31
DSM3:48 pmDes Moines
5h 37m
1 stop
SDF10:25 pmLouisville Intl
Nov 2
SDF5:25 amLouisville Intl
8h 06m
1 stop
DSM12:31 pmDes Moines
$297
Find similar

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Oct 8
DSM2:13 pmDes Moines
3h 58m
1 stop
SDF7:11 pmLouisville Intl
Oct 15
SDF7:09 amLouisville Intl
7h 19m
1 stop
DSM1:28 pmDes Moines
$237
Find similar
Delta
Sep 9
DSM3:50 pmDes Moines
5h 52m
1 stop
SDF10:42 pmLouisville Intl
Sep 13
SDF12:48 pmLouisville Intl
4h 34m
1 stop
DSM4:22 pmDes Moines
$367
Find similar
Delta
Aug 28
DSM10:47 amDes Moines
6h 29m
1 stop
SDF6:16 pmLouisville Intl
Aug 30
SDF4:25 pmLouisville Intl
5h 34m
1 stop
DSM8:59 pmDes Moines
$487
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/8

2:13 pm-7:11 pm

1 stop3h 58m

Louisville Intl

Wed 10/15

7:09 am-1:28 pm

1 stop7h 19m

$237

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 9/22

6:09 pm-11:03 pm

1 stop3h 54m

Louisville Intl

Thu 9/25

7:35 am-1:05 pm

1 stop6h 30m

$247

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 10/8

7:30 am-2:02 pm

1 stop29h 32m

Louisville Intl

Wed 10/15

5:31 pm-7:57 pm

2 stops27h 26m

$296

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 10/31

3:48 pm-10:25 pm

1 stop5h 37m

Louisville Intl

Sun 11/2

5:25 am-12:31 pm

1 stop8h 06m

$297

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 10/21

6:20 am-6:05 pm

2 stops10h 45m

Louisville Intl

Wed 10/22

1:45 pm-9:50 pm

2 stops9h 05m

$307

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 10/21

10:15 am-11:35 pm

1 stop12h 20m

Louisville Intl

Wed 10/22

3:50 pm-9:50 pm

2 stops7h 00m

$308

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 10/31

7:30 am-6:37 pm

2 stops10h 07m

Louisville Intl

Sun 11/2

5:25 am-12:31 pm

1 stop8h 06m

$342

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 9/9

3:50 pm-10:42 pm

1 stop5h 52m

Louisville Intl

Sat 9/13

12:48 pm-4:22 pm

1 stop4h 34m

$367

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 9/10

6:15 am-1:30 pm

1 stop6h 15m

Louisville Intl

Mon 9/15

5:52 pm-9:45 pm

1 stop4h 53m

$427

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 9/10

3:25 pm-8:28 pm

1 stop4h 03m

Louisville Intl

Mon 9/15

1:40 pm-9:45 pm

2 stops9h 05m

$448

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Louisville?

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of February, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $327.

What is the cheapest day to depart on your flight to Louisville?

On average, the least expensive day to fly to Louisville from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $333. However, this price may fluctuate depending on the airline, the season, and holidays. Flights from Des Moines to Louisville on a Sunday will generally be more expensive and average around $457. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Louisville?

Our data shows that the cheapest Des Moines to Louisville flights are usually those with departure times at noon. Our users have found flights to Louisville at noon for as low as $322. In the morning is when there is more demand to fly to Louisville, so prices are often more expensive at around $396 per ticket.

How have Des Moines to Louisville flight prices changed over time?

As of August 2025, prices for Des Moines to Louisville flights are approximately 29% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Direct flights

None
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 23m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $264Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $306Free CancellationRating
7.4
8,945 reviews
Search United Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Bardstown
West Baden Springs
Jeffersonville
Shepherdsville
New Albany
Corydon
Elizabeth
Charlestown
Springfield
Brandenburg
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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