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Cheap flights from Des Moines to Louisville from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:45 pm - 8:25 pm
DSM
-
SDF
3h 40m
1 stop
Southwest Logo
8:45 am - 11:30 am
SDF
-
DSM
3h 45m
1 stop
$307Southwest
Tue, Jun 9 - Tue, Jun 16
Delta Logo
6:37 pm - 12:26 am
DSM
-
SDF
4h 49m
1 stop
Delta Logo
7:05 am - 1:34 pm
SDF
-
DSM
7h 29m
1 stop
$317Delta
Wed, Jul 15 - Thu, Jul 23
Southwest Logo
6:25 am - 8:25 pm
DSM
-
SDF
13h 00m
2 stops
Southwest Logo
8:45 am - 11:30 am
SDF
-
DSM
3h 45m
1 stop
$318Southwest
Tue, Jun 9 - Tue, Jun 16
Delta Logo
6:08 am - 1:39 pm
DSM
-
SDF
6h 31m
1 stop
Delta Logo
5:26 pm - 8:41 pm
SDF
-
DSM
4h 15m
1 stop
$327Delta
Tue, Jun 30 - Fri, Jul 3
American Airlines Logo
1:51 pm - 10:27 pm
DSM
-
SDF
7h 36m
2 stops
American Airlines Logo
6:43 am - 1:04 pm
SDF
-
DSM
7h 21m
1 stop
$332American Airlines
Tue, Jun 30 - Fri, Jul 3
Southwest Logo
6:25 am - 9:40 pm
DSM
-
SDF
14h 15m
2 stops
Southwest Logo
7:25 am - 10:45 pm
SDF
-
DSM
16h 20m
2 stops
$334Southwest
Tue, Jun 9 - Tue, Jun 16
Delta Logo
6:03 pm - 11:59 pm
DSM
-
SDF
4h 56m
1 stop
Delta Logo
7:05 am - 10:43 am
SDF
-
DSM
4h 38m
1 stop
$337Delta
Mon, Jun 8 - Fri, Jun 12
United Airlines Logo
6:50 pm - 11:56 pm
DSM
-
SDF
4h 06m
1 stop
United Airlines Logo
7:47 pm - 10:51 pm
SDF
-
DSM
4h 04m
1 stop
$341United Airlines
Wed, Jun 10 - Sun, Jun 14
Southwest Logo
4:40 pm - 12:25 am
DSM
-
SDF
6h 45m
2 stops
Southwest Logo
8:05 pm - 11:30 pm
SDF
-
DSM
4h 25m
1 stop
$342Southwest
Mon, Jun 22 - Thu, Jun 25
Southwest Logo
6:25 am - 9:40 pm
DSM
-
SDF
14h 15m
2 stops
Southwest Logo
5:35 am - 10:45 pm
SDF
-
DSM
18h 10m
2 stops
$349Southwest
Tue, Jun 9 - Wed, Jun 10

Southwest flights from Des Moines to Louisville

Our best Southwest deals on Des Moines to Louisville flight tickets
Southwest
Jun 9
DSM3:45 pmDes Moines
3h 40m
1 stop
SDF8:25 pmLouisville Intl
Jun 16
SDF8:45 amLouisville Intl
3h 45m
1 stop
DSM11:30 amDes Moines
$307
Southwest
Jun 9
DSM6:25 amDes Moines
13h 00m
2 stops
SDF8:25 pmLouisville Intl
Jun 16
SDF8:45 amLouisville Intl
3h 45m
1 stop
DSM11:30 amDes Moines
$318
Southwest
Jun 9
DSM6:25 amDes Moines
14h 15m
2 stops
SDF9:40 pmLouisville Intl
Jun 16
SDF7:25 amLouisville Intl
16h 20m
2 stops
DSM10:45 pmDes Moines
$334

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Jul 15
DSM6:37 pmDes Moines
4h 49m
1 stop
SDF12:26 amLouisville Intl
Jul 23
SDF7:05 amLouisville Intl
7h 29m
1 stop
DSM1:34 pmDes Moines
$317
Delta
Jun 30
DSM6:08 amDes Moines
6h 31m
1 stop
SDF1:39 pmLouisville Intl
Jul 3
SDF5:26 pmLouisville Intl
4h 15m
1 stop
DSM8:41 pmDes Moines
$327
Delta
Jun 8
DSM6:03 pmDes Moines
4h 56m
1 stop
SDF11:59 pmLouisville Intl
Jun 12
SDF7:05 amLouisville Intl
4h 38m
1 stop
DSM10:43 amDes Moines
$337

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/9

3:45 pm-8:25 pm

1 stop3h 40m

Louisville Intl

Tue 6/16

8:45 am-11:30 am

1 stop3h 45m

$307

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 7/15

6:37 pm-12:26 am

1 stop4h 49m

Louisville Intl

Thu 7/23

7:05 am-1:34 pm

1 stop7h 29m

$317

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/9

6:25 am-8:25 pm

2 stops13h 00m

Louisville Intl

Tue 6/16

8:45 am-11:30 am

1 stop3h 45m

$318

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/30

6:08 am-1:39 pm

1 stop6h 31m

Louisville Intl

Fri 7/3

5:26 pm-8:41 pm

1 stop4h 15m

$327

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/30

1:51 pm-10:27 pm

2 stops7h 36m

Louisville Intl

Fri 7/3

6:43 am-1:04 pm

1 stop7h 21m

$332

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/9

6:25 am-9:40 pm

2 stops14h 15m

Louisville Intl

Tue 6/16

7:25 am-10:45 pm

2 stops16h 20m

$334

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 6/8

6:03 pm-11:59 pm

1 stop4h 56m

Louisville Intl

Fri 6/12

7:05 am-10:43 am

1 stop4h 38m

$337

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 6/10

6:50 pm-11:56 pm

1 stop4h 06m

Louisville Intl

Sun 6/14

7:47 pm-10:51 pm

1 stop4h 04m

$341

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Mon 6/22

4:40 pm-12:25 am

2 stops6h 45m

Louisville Intl

Thu 6/25

8:05 pm-11:30 pm

1 stop4h 25m

$342

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/9

6:25 am-9:40 pm

2 stops14h 15m

Louisville Intl

Wed 6/10

5:35 am-10:45 pm

2 stops18h 10m

$349

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Louisville?

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of January, then departing from Des Moines during the month October is also very affordable. Most momondo users find prices during this month for around $298.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 22% on your flight if you consider stops on a Des Moines to Louisville flight.

How have Des Moines to Louisville flight prices changed over time?

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

4h 16m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 4h 16m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

Frequently asked questions about flying from Des Moines to Louisville

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 4h 16m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $129Free CancellationRating
7.9
8,450 reviews
Search Delta flights
United AirlinesPriceFrom $148Free CancellationRating
7.4
9,706 reviews
Search United Airlines flights
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
New Albany
Shepherdsville
Brandenburg
Corydon
Elizabeth
Charlestown
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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