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Cheap flights from Des Moines to Louisville from $307

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 6/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:45 pm - 8:25 pm
DSM
-
SDF
3h 40m
1 stop
Southwest Logo
8:45 am - 11:25 am
SDF
-
DSM
3h 40m
1 stop
$307Southwest
Wed, Jun 10 - Sun, Jun 14
Southwest Logo
5:20 am - 10:05 am
DSM
-
SDF
3h 45m
1 stop
Southwest Logo
5:25 am - 11:25 am
SDF
-
DSM
7h 00m
2 stops
$312Southwest
Wed, Jun 10 - Sun, Jun 14
American Airlines Logo
5:01 pm - 12:23 am
DSM
-
SDF
6h 22m
1 stop
American Airlines Logo
6:00 am - 10:26 am
SDF
-
DSM
5h 26m
1 stop
$314American Airlines
Fri, May 8 - Fri, May 15
Southwest Logo
5:35 am - 10:05 am
DSM
-
SDF
3h 30m
1 stop
Southwest Logo
7:15 pm - 10:10 pm
SDF
-
DSM
3h 55m
1 stop
$317Southwest
Sat, May 30 - Tue, Jun 2
United Airlines Logo
1:35 pm - 10:59 pm
DSM
-
SDF
8h 24m
1 stop
United Airlines Logo
3:25 pm - 8:30 pm
SDF
-
DSM
6h 05m
1 stop
$320United Airlines
Sat, May 23 - Wed, May 27
Southwest Logo
5:35 am - 10:05 am
DSM
-
SDF
3h 30m
1 stop
Southwest Logo
3:45 pm - 10:10 pm
SDF
-
DSM
7h 25m
2 stops
$322Southwest
Sat, May 30 - Tue, Jun 2
Delta Logo
6:31 pm - 11:59 pm
DSM
-
SDF
4h 28m
1 stop
Delta Logo
6:00 am - 11:05 am
SDF
-
DSM
6h 05m
1 stop
$332Delta
Fri, Apr 24 - Sun, Apr 26
Delta Logo
6:07 am - 1:39 pm
DSM
-
SDF
6h 32m
1 stop
Delta Logo
5:59 pm - 8:59 pm
SDF
-
DSM
4h 00m
1 stop
$347Delta
Tue, Jun 30 - Fri, Jul 3
Southwest Logo
5:35 am - 11:20 pm
DSM
-
SDF
16h 45m
2 stops
Southwest Logo
4:40 pm - 10:10 pm
SDF
-
DSM
6h 30m
2 stops
$349Southwest
Sat, May 30 - Tue, Jun 2
American Airlines Logo
3:20 pm - 11:11 pm
DSM
-
SDF
6h 51m
1 stop
American Airlines Logo
6:00 am - 10:26 am
SDF
-
DSM
5h 26m
1 stop
$352American Airlines
Fri, Apr 17 - Sun, Apr 19

Southwest flights from Des Moines to Louisville

Our best Southwest deals on Des Moines to Louisville flight tickets
Southwest
Jun 10
DSM3:45 pmDes Moines
3h 40m
1 stop
SDF8:25 pmLouisville Intl
Jun 14
SDF8:45 amLouisville Intl
3h 40m
1 stop
DSM11:25 amDes Moines
$307
Southwest
Jun 10
DSM5:20 amDes Moines
3h 45m
1 stop
SDF10:05 amLouisville Intl
Jun 14
SDF5:25 amLouisville Intl
7h 00m
2 stops
DSM11:25 amDes Moines
$312
Southwest
May 30
DSM5:35 amDes Moines
3h 30m
1 stop
SDF10:05 amLouisville Intl
Jun 2
SDF7:15 pmLouisville Intl
3h 55m
1 stop
DSM10:10 pmDes Moines
$317

United Airlines flights from Des Moines to Louisville

Our best United Airlines deals on Des Moines to Louisville flight tickets
United Airlines
May 23
DSM1:35 pmDes Moines
8h 24m
1 stop
SDF10:59 pmLouisville Intl
May 27
SDF3:25 pmLouisville Intl
6h 05m
1 stop
DSM8:30 pmDes Moines
$320
United Airlines
Apr 18
DSM7:16 pmDes Moines
3h 43m
1 stop
SDF11:59 pmLouisville Intl
Apr 22
SDF9:07 amLouisville Intl
4h 22m
1 stop
DSM12:29 pmDes Moines
$359
United Airlines
May 23
DSM6:00 amDes Moines
13h 25m
2 stops
SDF8:25 pmLouisville Intl
May 27
SDF5:20 amLouisville Intl
6h 07m
1 stop
DSM10:27 amDes Moines
$403

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 6/10

3:45 pm-8:25 pm

1 stop3h 40m

Louisville Intl

Sun 6/14

8:45 am-11:25 am

1 stop3h 40m

$307

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 6/10

5:20 am-10:05 am

1 stop3h 45m

Louisville Intl

Sun 6/14

5:25 am-11:25 am

2 stops7h 00m

$312

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 5/8

5:01 pm-12:23 am

1 stop6h 22m

Louisville Intl

Fri 5/15

6:00 am-10:26 am

1 stop5h 26m

$314

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 5/30

5:35 am-10:05 am

1 stop3h 30m

Louisville Intl

Tue 6/2

7:15 pm-10:10 pm

1 stop3h 55m

$317

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 5/23

1:35 pm-10:59 pm

1 stop8h 24m

Louisville Intl

Wed 5/27

3:25 pm-8:30 pm

1 stop6h 05m

$320

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 5/30

5:35 am-10:05 am

1 stop3h 30m

Louisville Intl

Tue 6/2

3:45 pm-10:10 pm

2 stops7h 25m

$322

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 4/24

6:31 pm-11:59 pm

1 stop4h 28m

Louisville Intl

Sun 4/26

6:00 am-11:05 am

1 stop6h 05m

$332

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 6/30

6:07 am-1:39 pm

1 stop6h 32m

Louisville Intl

Fri 7/3

5:59 pm-8:59 pm

1 stop4h 00m

$347

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 5/30

5:35 am-11:20 pm

2 stops16h 45m

Louisville Intl

Tue 6/2

4:40 pm-10:10 pm

2 stops6h 30m

$349

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 4/17

3:20 pm-11:11 pm

1 stop6h 51m

Louisville Intl

Sun 4/19

6:00 am-10:26 am

1 stop5h 26m

$352

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of January, then departing from Des Moines during the month October is also very affordable. Most momondo users find prices during this month for around $305.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 15% on your flight if you consider stops on a Des Moines to Louisville flight.

How have Des Moines to Louisville flight prices changed over time?

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Fastest flight time

3h 40m

Direct flights

None
The fastest flight from Des Moines to Louisville takes 3h 40m
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 40m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $129Free CancellationRating
7.9
8,327 reviews
Search Delta flights
United AirlinesPriceFrom $148Free CancellationRating
7.4
9,478 reviews
Search United Airlines flights
American AirlinesPriceFrom $260Free CancellationRating
7.1
11,493 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Bardstown
West Baden Springs
Jeffersonville
New Albany
Shepherdsville
Corydon
Brandenburg
Elizabeth
Charlestown
Springfield
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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