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Cheap flights from Des Moines to Louisville from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Louisville departing on 10/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:55 am - 3:49 pmDSM-SDF
3h 54m1 stop
Delta Logo
6:00 am - 10:23 amSDF-DSM
5h 23m1 stop
$203Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
2:08 pm - 9:48 pmDSM-SDF
6h 40m1 stop
American Airlines Logo
6:28 pm - 10:59 pmSDF-DSM
5h 31m1 stop
$216American Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13
Delta Logo
10:15 am - 5:42 pmDSM-SDF
6h 27m1 stop
Delta Logo
6:00 am - 10:23 amSDF-DSM
5h 23m1 stop
$251Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
4:02 pm - 12:22 amDSM-SDF
7h 20m2 stops
American Airlines Logo
6:34 pm - 10:59 pmSDF-DSM
5h 25m1 stop
$256American Airlines
Find Deal
Sat, Nov 15 - Tue, Nov 18
American Airlines Logo
1:17 pm - 9:49 pmDSM-SDF
7h 32m2 stops
American Airlines Logo
7:04 pm - 11:35 pmSDF-DSM
5h 31m1 stop
$258American Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
Delta Logo
4:00 pm - 10:55 pmDSM-SDF
5h 55m1 stop
Delta Logo
6:00 am - 10:23 amSDF-DSM
5h 23m1 stop
$261Delta
Find Deal
Fri, Jan 16 - Tue, Jan 20
Southwest Logo
8:20 am - 9:30 pmDSM-SDF
12h 10m1 stop
Southwest Logo
1:55 pm - 11:35 pmSDF-DSM
10h 40m2 stops
$325Southwest
Find Deal
Fri, Dec 5 - Sun, Dec 7
Southwest Logo
6:15 am - 4:35 pmDSM-SDF
9h 20m2 stops
Southwest Logo
1:55 pm - 11:35 pmSDF-DSM
10h 40m2 stops
$338Southwest
Find Deal
Fri, Dec 5 - Sun, Dec 7
United Airlines Logo
3:17 pm - 8:28 pmDSM-SDF
4h 11m1 stop
United Airlines Logo
9:00 am - 2:20 pmSDF-DSM
6h 20m1 stop
$387United Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
United Airlines Logo
8:15 am - 11:32 amDSM-SDF
26h 17m2 stops
United Airlines Logo
7:00 am - 10:53 amSDF-DSM
4h 53m1 stop
$420United Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13

Delta flights from Des Moines to Louisville

Our best Delta deals on Des Moines to Louisville flight tickets
Delta
Mar 3
DSM10:55 amDes Moines
3h 54m
1 stop
SDF3:49 pmLouisville Intl
Mar 4
SDF6:00 amLouisville Intl
5h 23m
1 stop
DSM10:23 amDes Moines
$203
Find similar
Delta
Mar 3
DSM10:15 amDes Moines
6h 27m
1 stop
SDF5:42 pmLouisville Intl
Mar 4
SDF6:00 amLouisville Intl
5h 23m
1 stop
DSM10:23 amDes Moines
$251
Find similar
Delta
Jan 16
DSM4:00 pmDes Moines
5h 55m
1 stop
SDF10:55 pmLouisville Intl
Jan 20
SDF6:00 amLouisville Intl
5h 23m
1 stop
DSM10:23 amDes Moines
$261
Find similar

American Airlines flights from Des Moines to Louisville

Our best American Airlines deals on Des Moines to Louisville flight tickets
American Airlines
Dec 11
DSM2:08 pmDes Moines
6h 40m
1 stop
SDF9:48 pmLouisville Intl
Dec 13
SDF6:28 pmLouisville Intl
5h 31m
1 stop
DSM10:59 pmDes Moines
$216
Find similar
American Airlines
Nov 15
DSM4:02 pmDes Moines
7h 20m
2 stops
SDF12:22 amLouisville Intl
Nov 18
SDF6:34 pmLouisville Intl
5h 25m
1 stop
DSM10:59 pmDes Moines
$256
Find similar
American Airlines
Dec 3
DSM1:17 pmDes Moines
7h 32m
2 stops
SDF9:49 pmLouisville Intl
Dec 10
SDF7:04 pmLouisville Intl
5h 31m
1 stop
DSM11:35 pmDes Moines
$258
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 21, 2025.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

10:55 am-3:49 pm

1 stop3h 54m

Louisville Intl

Wed 3/4

6:00 am-10:23 am

1 stop5h 23m

$203

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 12/11

2:08 pm-9:48 pm

1 stop6h 40m

Louisville Intl

Sat 12/13

6:28 pm-10:59 pm

1 stop5h 31m

$216

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Tue 3/3

10:15 am-5:42 pm

1 stop6h 27m

Louisville Intl

Wed 3/4

6:00 am-10:23 am

1 stop5h 23m

$251

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Sat 11/15

4:02 pm-12:22 am

2 stops7h 20m

Louisville Intl

Tue 11/18

6:34 pm-10:59 pm

1 stop5h 25m

$256

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Wed 12/3

1:17 pm-9:49 pm

2 stops7h 32m

Louisville Intl

Wed 12/10

7:04 pm-11:35 pm

1 stop5h 31m

$258

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 1/16

4:00 pm-10:55 pm

1 stop5h 55m

Louisville Intl

Tue 1/20

6:00 am-10:23 am

1 stop5h 23m

$261

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 12/5

8:20 am-9:30 pm

1 stop12h 10m

Louisville Intl

Sun 12/7

1:55 pm-11:35 pm

2 stops10h 40m

$325

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Fri 12/5

6:15 am-4:35 pm

2 stops9h 20m

Louisville Intl

Sun 12/7

1:55 pm-11:35 pm

2 stops10h 40m

$338

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 12/4

3:17 pm-8:28 pm

1 stop4h 11m

Louisville Intl

Thu 12/11

9:00 am-2:20 pm

1 stop6h 20m

$387

Des MoinesLouisville

DSM - SDF

DSMSDF

Des Moines

Thu 12/11

8:15 am-11:32 am

2 stops26h 17m

Louisville Intl

Sat 12/13

7:00 am-10:53 am

1 stop4h 53m

$420

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from Des Moines to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Louisville?

If you are unable to visit Louisville during the month of August, then departing from Des Moines during the month February is also very affordable. Most momondo users find prices during this month for around $317.

What is the cheapest day to depart on your flight to Louisville?

On average, the least expensive day to fly to Louisville from Des Moines is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $333. However, this price may fluctuate depending on the airline, the season, and holidays. Flights from Des Moines to Louisville on a Sunday will generally be more expensive and average around $457. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Louisville?

Our data shows that the cheapest Des Moines to Louisville flights are usually those with departure times at noon. Our users have found flights to Louisville at noon for as low as $322. In the morning is when there is more demand to fly to Louisville, so prices are often more expensive at around $396 per ticket.

Can stopping save me money on Des Moines to Louisville flights?

You could potentially save up to 21% on your flight if you consider stops on a Des Moines to Louisville flight.

How have Des Moines to Louisville flight prices changed over time?

As of October 2025, prices for Des Moines to Louisville flights are approximately 65% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Louisville (DSM to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Louisville

Direct flights

None
There are no direct flights from Des Moines to Louisville. There are no popular flight routes from Des Moines to Louisville.
Search flight deals

  • How far is Des Moines to Louisville Intl by plane?

    Louisville Intl is 476.1 mi away from Des Moines. By plane, this route typically takes 3h 41m.

  • When did momondo last update prices for flights from Des Moines Airport to Louisville Intl Airport?

    Prices for flights from Des Moines Airport to Louisville Intl Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Louisville Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The necessary travel and health documents for your Louisville Intl Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Louisville?

Best airlines flying from Des Moines to Louisville

Compare and see reviews for airlines that fly from Des Moines to Louisville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $148Free CancellationRating
7.4
8,991 reviews
Search United Airlines flights
DeltaPriceFrom $196Free CancellationRating
7.9
7,978 reviews
Search Delta flights
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,023 reviews
Search American Airlines flights

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
West Baden Springs
Bardstown
Jeffersonville
Shepherdsville
New Albany
Corydon
Elizabeth
Charlestown
Springfield
Georgetown
Brandenburg

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Louisville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Louisville. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Louisville with flexible booking policies on momondo?

Yes. All flights to Louisville from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Louisville?

momondo provides multiple filters to help you find the best flight to Louisville from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Louisville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Louisville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Louisville and let you know when they change.

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