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Cheap flights from Des Moines to Santo Domingo from $397

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 1/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:58 pm - 3:35 pm
DSM
-
SDQ
22h 37m1 stop
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$397Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 3:35 pm
DSM
-
SDQ
22h 37m1 stop
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$398Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 3:35 pm
DSM
-
SDQ
22h 37m1 stop
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$401Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 3:35 pm
DSM
-
SDQ
22h 37m1 stop
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$408Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
4:30 pm - 9:59 am
DSM
-
SDQ
39h 29m2 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$423Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
4:30 pm - 9:59 am
DSM
-
SDQ
39h 29m2 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$427Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
4:30 pm - 9:59 am
DSM
-
SDQ
39h 29m2 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$430Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 4:26 pm
DSM
-
SDQ
23h 28m2 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$446Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 4:26 pm
DSM
-
SDQ
23h 28m3 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$455Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
2:58 pm - 4:26 pm
DSM
-
SDQ
23h 28m3 stops
Multiple Airlines Logo
4:40 pm - 10:46 pm
SDQ
-
DSM
8h 06m1 stop
$460Multiple Airlines
Thu, Jan 22 - Thu, Jan 29

American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
Jan 22
DSM7:00 amDes Moines
13h 39m
2 stops
SDQ10:39 pmSanto Domingo Las Americas
Jan 29
SDQ4:47 pmSanto Domingo Las Americas
8h 42m
1 stop
DSM11:29 pmDes Moines
$523
Find similar
American Airlines
Jan 23
DSM4:00 pmDes Moines
18h 21m
2 stops
SDQ12:21 pmSanto Domingo Las Americas
Jan 30
SDQ1:23 pmSanto Domingo Las Americas
11h 45m
2 stops
DSM11:08 pmDes Moines
$532
Find similar
American Airlines
Jan 23
DSM5:51 pmDes Moines
18h 09m
2 stops
SDQ2:00 pmSanto Domingo Las Americas
Jan 30
SDQ6:00 amSanto Domingo Las Americas
13h 06m
2 stops
DSM5:06 pmDes Moines
$533
Find similar

Delta flights from Des Moines to Santo Domingo

Our best Delta deals on Des Moines to Santo Domingo flight tickets
Delta
Jan 21
DSM5:35 amDes Moines
6h 46m
1 stop
SDQ2:21 pmSanto Domingo Las Americas
Jan 28
SDQ7:30 amSanto Domingo Las Americas
15h 24m
2 stops
DSM8:54 pmDes Moines
$522
Find similar
Delta
Jan 22
DSM5:35 amDes Moines
6h 46m
1 stop
SDQ2:21 pmSanto Domingo Las Americas
Jan 29
SDQ3:46 pmSanto Domingo Las Americas
8h 43m
1 stop
DSM10:29 pmDes Moines
$528
Find similar
Delta
Jan 22
DSM6:24 amDes Moines
10h 50m
2 stops
SDQ7:14 pmSanto Domingo Las Americas
Jan 26
SDQ8:45 pmSanto Domingo Las Americas
15h 56m
2 stops
DSM10:41 amDes Moines
$542
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-3:35 pm

1 stop22h 37m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$397

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-3:35 pm

1 stop22h 37m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$398

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-3:35 pm

1 stop22h 37m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$401

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-3:35 pm

1 stop22h 37m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$408

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

4:30 pm-9:59 am

2 stops39h 29m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$423

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

4:30 pm-9:59 am

2 stops39h 29m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$427

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

4:30 pm-9:59 am

2 stops39h 29m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$430

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-4:26 pm

2 stops23h 28m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$446

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-4:26 pm

3 stops23h 28m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$455

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 1/22

2:58 pm-4:26 pm

3 stops23h 28m

Santo Domingo Las Americas

Thu 1/29

4:40 pm-10:46 pm

1 stop8h 06m

$460

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Des Moines to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $613. The most expensive day to fly to Santo Domingo is Friday, with ticket prices averaging around $823.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $674. Try not to purchase tickets in the morning because they tend to be around $690. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Fastest flight time

10h 11m

Direct flights

None
The fastest flight from Des Moines to Santo Domingo takes 10h 11m
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
Search flight deals

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 6h 46m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $524Free CancellationRating
7.9
8,011 reviews
Search Delta flights
American AirlinesPriceFrom $529Free CancellationRating
7.2
11,045 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

I’m not ready to book a flight from Des Moines to Santo Domingo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Santo Domingo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santo Domingo and let you know when they change.

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