Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Santo Domingo from $440

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 3/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:23 pm - 1:25 pm
DSM
-
SDQ
23h 02m
1 stop
Multiple Airlines Logo
3:35 pm - 1:46 pm
SDQ
-
DSM
47h 11m
2 stops
$440Multiple Airlines
Tue, Mar 24 - Tue, Mar 31
Multiple Airlines Logo
10:26 am - 1:50 am
DSM
-
SDQ
14h 24m
2 stops
Multiple Airlines Logo
3:55 am - 1:46 pm
SDQ
-
DSM
10h 51m
1 stop
$457Multiple Airlines
Fri, Mar 27 - Sat, Apr 4
Multiple Airlines Logo
7:27 pm - 1:10 pm
DSM
-
SDQ
39h 43m
2 stops
Multiple Airlines Logo
3:32 pm - 10:51 pm
SDQ
-
DSM
9h 19m
1 stop
$489Multiple Airlines
Thu, Feb 26 - Thu, Mar 5
American Airlines Logo
7:00 am - 3:03 pm
DSM
-
SDQ
7h 03m
1 stop
American Airlines Logo
2:15 pm - 11:56 pm
SDQ
-
DSM
10h 41m
1 stop
$539American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
6:40 am - 10:53 pm
DSM
-
SDQ
15h 13m
2 stops
American Airlines Logo
6:00 am - 7:57 pm
SDQ
-
DSM
14h 57m
2 stops
$543American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
7:00 am - 10:59 pm
DSM
-
SDQ
14h 59m
2 stops
American Airlines Logo
7:38 pm - 12:56 pm
SDQ
-
DSM
18h 18m
2 stops
$553American Airlines
Mon, May 25 - Mon, Jun 1
Delta Logo
10:40 am - 12:32 am
DSM
-
SDQ
11h 52m
2 stops
Delta Logo
7:30 am - 8:49 pm
SDQ
-
DSM
15h 19m
2 stops
$613Delta
Thu, Feb 26 - Thu, Mar 5
Multiple Airlines Logo
9:59 pm - 2:32 pm
DSM
-
SDQ
15h 33m
2 stops
Multiple Airlines Logo
3:37 pm - 11:24 pm
SDQ
-
DSM
8h 47m
1 stop
$622Multiple Airlines
Mon, May 25 - Mon, Jun 1
Multiple Airlines Logo
7:35 am - 5:29 am
DSM
-
SDQ
20h 54m
1 stop
Multiple Airlines Logo
3:37 pm - 11:24 pm
SDQ
-
DSM
8h 47m
1 stop
$638Multiple Airlines
Mon, May 25 - Mon, Jun 1
American Airlines Logo
7:00 am - 10:53 pm
DSM
-
SDQ
14h 53m
1 stop
American Airlines Logo
6:00 am - 11:56 pm
SDQ
-
DSM
18h 56m
1 stop
$658American Airlines
Fri, Mar 27 - Sun, Apr 5

American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
Mar 24
DSM7:00 amDes Moines
7h 03m
1 stop
SDQ3:03 pmSanto Domingo Las Americas
Mar 31
SDQ2:15 pmSanto Domingo Las Americas
10h 41m
1 stop
DSM11:56 pmDes Moines
$539
American Airlines
Mar 24
DSM6:40 amDes Moines
15h 13m
2 stops
SDQ10:53 pmSanto Domingo Las Americas
Mar 31
SDQ6:00 amSanto Domingo Las Americas
14h 57m
2 stops
DSM7:57 pmDes Moines
$543
American Airlines
May 25
DSM7:00 amDes Moines
14h 59m
2 stops
SDQ10:59 pmSanto Domingo Las Americas
Jun 1
SDQ7:38 pmSanto Domingo Las Americas
18h 18m
2 stops
DSM12:56 pmDes Moines
$553

United Airlines flights from Des Moines to Santo Domingo

Our best United Airlines deals on Des Moines to Santo Domingo flight tickets
United Airlines
Feb 1
DSM8:00 amDes Moines
13h 46m
2 stops
SDQ11:46 pmSanto Domingo Las Americas
Feb 5
SDQ2:53 pmSanto Domingo Las Americas
22h 02m
2 stops
DSM10:55 amDes Moines
$703
United Airlines
Mar 15
DSM6:49 pmDes Moines
18h 17m
2 stops
SDQ2:06 pmSanto Domingo Las Americas
Mar 22
SDQ1:53 pmSanto Domingo Las Americas
21h 37m
2 stops
DSM10:30 amDes Moines
$1,167
United Airlines
Mar 14
DSM6:49 pmDes Moines
18h 17m
2 stops
SDQ2:06 pmSanto Domingo Las Americas
Mar 21
SDQ3:18 pmSanto Domingo Las Americas
27h 50m
2 stops
DSM6:08 pmDes Moines
$1,257

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 3/24

1:23 pm-1:25 pm

1 stop23h 02m

Santo Domingo Las Americas

Tue 3/31

3:35 pm-1:46 pm

2 stops47h 11m

$440

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 3/27

10:26 am-1:50 am

2 stops14h 24m

Santo Domingo Las Americas

Sat 4/4

3:55 am-1:46 pm

1 stop10h 51m

$457

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 2/26

7:27 pm-1:10 pm

2 stops39h 43m

Santo Domingo Las Americas

Thu 3/5

3:32 pm-10:51 pm

1 stop9h 19m

$489

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 3/24

7:00 am-3:03 pm

1 stop7h 03m

Santo Domingo Las Americas

Tue 3/31

2:15 pm-11:56 pm

1 stop10h 41m

$539

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 3/24

6:40 am-10:53 pm

2 stops15h 13m

Santo Domingo Las Americas

Tue 3/31

6:00 am-7:57 pm

2 stops14h 57m

$543

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 5/25

7:00 am-10:59 pm

2 stops14h 59m

Santo Domingo Las Americas

Mon 6/1

7:38 pm-12:56 pm

2 stops18h 18m

$553

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 2/26

10:40 am-12:32 am

2 stops11h 52m

Santo Domingo Las Americas

Thu 3/5

7:30 am-8:49 pm

2 stops15h 19m

$613

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 5/25

9:59 pm-2:32 pm

2 stops15h 33m

Santo Domingo Las Americas

Mon 6/1

3:37 pm-11:24 pm

1 stop8h 47m

$622

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 5/25

7:35 am-5:29 am

1 stop20h 54m

Santo Domingo Las Americas

Mon 6/1

3:37 pm-11:24 pm

1 stop8h 47m

$638

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 3/27

7:00 am-10:53 pm

1 stop14h 53m

Santo Domingo Las Americas

Sun 4/5

6:00 am-11:56 pm

1 stop18h 56m

$658

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Des Moines to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Des Moines to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Santo Domingo flight.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Fastest flight time

13h 37m

Direct flights

None
The fastest flight from Des Moines to Santo Domingo takes 13h 37m
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
Search flight deals

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 13h 37m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $524Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $542Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

I’m not ready to book a flight from Des Moines to Santo Domingo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Santo Domingo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santo Domingo and let you know when they change.

An easier way to manage your Santo Domingo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 2/28
Sat 3/7
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the Dominican Republic