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Cheap flights from Des Moines to Santo Domingo from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:58 pm - 6:49 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
27h 51m2 stops Philadelphia San Juan Luis Munoz Marin Intl
Multiple Airlines Logo
4:35 pm - 1:14 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
21h 39m1 stop Boston Logan Intl
$648Multiple Airlines
Sun, Sep 27 - Sun, Oct 4
American Airlines Logo
4:14 pm - 9:21 amDSM  Des Moines-SDQ Santo Domingo Las Americas
16h 07m2 stops Dallas/Fort Worth Miami
American Airlines Logo
2:15 pm - 11:41 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
10h 26m2 stops Miami Washington, D.C. Reagan-National
$712American Airlines
Fri, Sep 25 - Fri, Oct 2
American Airlines Logo
1:30 pm - 9:21 amDSM  Des Moines-SDQ Santo Domingo Las Americas
18h 51m2 stops Charlotte Douglas Miami
American Airlines Logo
9:30 am - 11:12 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
14h 42m2 stops Miami Dallas/Fort Worth
$714American Airlines
Wed, Sep 23 - Wed, Sep 30
Delta Logo
5:45 am - 1:27 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
6h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 10:26 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
8h 33m1 stop Atlanta Hartsfield-Jackson
$720Delta
Fri, Sep 25 - Fri, Oct 2
Delta Logo
5:45 am - 1:27 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
6h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:35 pm - 10:46 amSDQ  Santo Domingo Las Americas-DSM Des Moines
16h 11m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$725Delta
Fri, Sep 25 - Fri, Oct 2
American Airlines Logo
2:44 pm - 9:21 amDSM  Des Moines-SDQ Santo Domingo Las Americas
17h 37m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
2:15 pm - 11:41 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
10h 26m2 stops Miami Washington, D.C. Reagan-National
$725American Airlines
Sat, Sep 19 - Tue, Sep 22
American Airlines Logo
7:58 pm - 1:11 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
16h 13m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
10:21 am - 11:12 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
13h 51m2 stops Miami Dallas/Fort Worth
$730American Airlines
Sat, Sep 26 - Sat, Oct 3
Delta Logo
5:45 am - 1:27 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
6h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:53 pm - 10:26 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
8h 33m1 stop Atlanta Hartsfield-Jackson
$740Delta
Sat, Sep 19 - Tue, Sep 22
Delta Logo
5:45 am - 1:27 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
6h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:35 pm - 10:46 amSDQ  Santo Domingo Las Americas-DSM Des Moines
16h 11m2 stops New York John F Kennedy Intl Atlanta Hartsfield-Jackson
$745Delta
Sat, Sep 19 - Tue, Sep 22
Delta Logo
5:45 am - 6:07 pmDSM  Des Moines-SDQ Santo Domingo Las Americas
11h 22m2 stops Atlanta Hartsfield-Jackson New York John F Kennedy Intl
Delta Logo
2:53 pm - 10:26 pmSDQ  Santo Domingo Las Americas-DSM Des Moines
8h 33m1 stop Atlanta Hartsfield-Jackson
$785Delta
Sat, Sep 26 - Sat, Oct 3

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American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
Sep 25
DSM4:14 pmDes Moines
16h 07m
2 stops
SDQ9:21 amSanto Domingo Las Americas
Oct 2
SDQ2:15 pmSanto Domingo Las Americas
10h 26m
2 stops
DSM11:41 pmDes Moines
$712
American Airlines
Sep 23
DSM1:30 pmDes Moines
18h 51m
2 stops
SDQ9:21 amSanto Domingo Las Americas
Sep 30
SDQ9:30 amSanto Domingo Las Americas
14h 42m
2 stops
DSM11:12 pmDes Moines
$714
American Airlines
Sep 19
DSM2:44 pmDes Moines
17h 37m
2 stops
SDQ9:21 amSanto Domingo Las Americas
Sep 22
SDQ2:15 pmSanto Domingo Las Americas
10h 26m
2 stops
DSM11:41 pmDes Moines
$725

Delta flights from Des Moines to Santo Domingo

Our best Delta deals on Des Moines to Santo Domingo flight tickets
Delta
Sep 25
DSM5:45 amDes Moines
6h 42m
1 stop
SDQ1:27 pmSanto Domingo Las Americas
Oct 2
SDQ2:53 pmSanto Domingo Las Americas
8h 33m
1 stop
DSM10:26 pmDes Moines
$720
Delta
Sep 19
DSM5:45 amDes Moines
6h 42m
1 stop
SDQ1:27 pmSanto Domingo Las Americas
Sep 22
SDQ2:53 pmSanto Domingo Las Americas
8h 33m
1 stop
DSM10:26 pmDes Moines
$740
Delta
Sep 19
DSM5:45 amDes Moines
6h 42m
1 stop
SDQ1:27 pmSanto Domingo Las Americas
Sep 22
SDQ7:35 pmSanto Domingo Las Americas
16h 11m
2 stops
DSM10:46 amDes Moines
$745

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sun 9/27

1:58 pm-6:49 pm

2 stops27h 51m

Santo Domingo Las Americas

Sun 10/4

4:35 pm-1:14 pm

1 stop21h 39m

$648

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Fri 9/25

4:14 pm-9:21 am

2 stops16h 07m

Santo Domingo Las Americas

Fri 10/2

2:15 pm-11:41 pm

2 stops10h 26m

$712

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Wed 9/23

1:30 pm-9:21 am

2 stops18h 51m

Santo Domingo Las Americas

Wed 9/30

9:30 am-11:12 pm

2 stops14h 42m

$714
Quickest round-trip

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Fri 9/25

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Fri 10/2

2:53 pm-10:26 pm

1 stop8h 33m

$720

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Fri 9/25

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Fri 10/2

7:35 pm-10:46 am

2 stops16h 11m

$725

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sat 9/19

2:44 pm-9:21 am

2 stops17h 37m

Santo Domingo Las Americas

Tue 9/22

2:15 pm-11:41 pm

2 stops10h 26m

$725

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sat 9/26

7:58 pm-1:11 pm

2 stops16h 13m

Santo Domingo Las Americas

Sat 10/3

10:21 am-11:12 pm

2 stops13h 51m

$730

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sat 9/19

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Tue 9/22

2:53 pm-10:26 pm

1 stop8h 33m

$740

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sat 9/19

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Tue 9/22

7:35 pm-10:46 am

2 stops16h 11m

$745

Des MoinesSanto Domingo

DSM Des Moines - SDQ Santo Domingo Las Americas

DSMSDQ

Des Moines

Sat 9/26

5:45 am-6:07 pm

2 stops11h 22m

Santo Domingo Las Americas

Sat 10/3

2:53 pm-10:26 pm

1 stop8h 33m

$785

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Des Moines to Santo Domingo

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Can stopping save me money on Des Moines to Santo Domingo flights?

You could potentially save up to 12% on your flight if you consider stops on a Des Moines to Santo Domingo flight.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Fastest flight time

10h 24m

Direct flights

None
The fastest flight from Des Moines to Santo Domingo takes 10h 24m
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
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Frequently asked questions about flying from Des Moines to Santo Domingo

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 10h 24m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $542Free CancellationRating
7.1
11,915 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

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