Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Des Moines to Santo Domingo from $300

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 12/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Logo
7:30 am - 2:48 pmDSM-SDQ
30h 18m2 stops
Logo
3:54 pm - 9:51 amSDQ-DSM
18h 57m1 stop
$470
Find Deal
Wed, Oct 8 - Wed, Oct 15
Logo
7:30 am - 2:48 pmDSM-SDQ
30h 18m2 stops
Logo
3:54 pm - 9:51 amSDQ-DSM
18h 57m1 stop
$485
Find Deal
Wed, Oct 8 - Wed, Oct 15
Logo
10:51 am - 4:07 pmDSM-SDQ
28h 16m1 stop
Logo
3:54 pm - 5:14 pmSDQ-DSM
26h 20m2 stops
$513
Find Deal
Thu, Oct 9 - Thu, Oct 16
American Airlines Logo
5:00 am - 3:20 pmDSM-SDQ
9h 20m2 stops
American Airlines Logo
7:00 am - 5:02 pmSDQ-DSM
11h 02m2 stops
$518American Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
Logo
10:51 am - 4:07 pmDSM-SDQ
28h 16m1 stop
Logo
3:54 pm - 5:14 pmSDQ-DSM
26h 20m2 stops
$522
Find Deal
Thu, Oct 9 - Thu, Oct 16
American Airlines Logo
5:00 am - 8:30 pmDSM-SDQ
14h 30m2 stops
American Airlines Logo
10:25 am - 10:03 pmSDQ-DSM
12h 38m2 stops
$525American Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 15
United Airlines Logo
8:00 am - 1:50 amDSM-SDQ
16h 50m2 stops
United Airlines Logo
5:45 am - 5:24 pmSDQ-DSM
12h 39m2 stops
$649United Airlines
Find Deal
Sat, Oct 11 - Sat, Oct 18
Delta Logo
5:47 am - 1:41 pmDSM-SDQ
6h 54m1 stop
Delta Logo
2:56 pm - 10:30 pmSDQ-DSM
8h 34m1 stop
$664Delta
Find Deal
Thu, Oct 9 - Thu, Oct 16
Delta Logo
5:47 am - 1:41 pmDSM-SDQ
6h 54m1 stop
Delta Logo
2:56 pm - 10:30 pmSDQ-DSM
8h 34m1 stop
$730Delta
Find Deal
Wed, Oct 8 - Wed, Oct 15
United Airlines Logo
6:30 am - 1:50 amDSM-SDQ
18h 20m2 stops
United Airlines Logo
5:45 am - 9:50 pmSDQ-DSM
17h 05m2 stops
$764United Airlines
Find Deal
Thu, Oct 9 - Thu, Oct 16

American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
Oct 8
DSM5:00 amDes Moines
9h 20m
2 stops
SDQ3:20 pmSanto Domingo Las Americas
Oct 15
SDQ7:00 amSanto Domingo Las Americas
11h 02m
2 stops
DSM5:02 pmDes Moines
$518
Find similar
American Airlines
Oct 8
DSM5:00 amDes Moines
14h 30m
2 stops
SDQ8:30 pmSanto Domingo Las Americas
Oct 15
SDQ10:25 amSanto Domingo Las Americas
12h 38m
2 stops
DSM10:03 pmDes Moines
$525
Find similar
American Airlines
Oct 10
DSM6:00 amDes Moines
13h 30m
2 stops
SDQ8:30 pmSanto Domingo Las Americas
Oct 17
SDQ2:35 pmSanto Domingo Las Americas
10h 24m
2 stops
DSM11:59 pmDes Moines
$528
Find similar

United Airlines flights from Des Moines to Santo Domingo

Our best United Airlines deals on Des Moines to Santo Domingo flight tickets
United Airlines
Oct 11
DSM8:00 amDes Moines
16h 50m
2 stops
SDQ1:50 amSanto Domingo Las Americas
Oct 18
SDQ5:45 amSanto Domingo Las Americas
12h 39m
2 stops
DSM5:24 pmDes Moines
$649
Find similar
United Airlines
Oct 9
DSM6:30 amDes Moines
18h 20m
2 stops
SDQ1:50 amSanto Domingo Las Americas
Oct 16
SDQ5:45 amSanto Domingo Las Americas
17h 05m
2 stops
DSM9:50 pmDes Moines
$764
Find similar
United Airlines
Oct 9
DSM8:00 amDes Moines
16h 50m
2 stops
SDQ1:50 amSanto Domingo Las Americas
Oct 16
SDQ5:45 amSanto Domingo Las Americas
17h 05m
2 stops
DSM9:50 pmDes Moines
$994
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 27, 2025.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 10/8

7:30 am-2:48 pm

2 stops30h 18m

Santo Domingo Las Americas

Wed 10/15

3:54 pm-9:51 am

1 stop18h 57m

$470

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 10/8

7:30 am-2:48 pm

2 stops30h 18m

Santo Domingo Las Americas

Wed 10/15

3:54 pm-9:51 am

1 stop18h 57m

$485

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

10:51 am-4:07 pm

1 stop28h 16m

Santo Domingo Las Americas

Thu 10/16

3:54 pm-5:14 pm

2 stops26h 20m

$513

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 10/8

5:00 am-3:20 pm

2 stops9h 20m

Santo Domingo Las Americas

Wed 10/15

7:00 am-5:02 pm

2 stops11h 02m

$518

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

10:51 am-4:07 pm

1 stop28h 16m

Santo Domingo Las Americas

Thu 10/16

3:54 pm-5:14 pm

2 stops26h 20m

$522

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 10/8

5:00 am-8:30 pm

2 stops14h 30m

Santo Domingo Las Americas

Wed 10/15

10:25 am-10:03 pm

2 stops12h 38m

$525

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sat 10/11

8:00 am-1:50 am

2 stops16h 50m

Santo Domingo Las Americas

Sat 10/18

5:45 am-5:24 pm

2 stops12h 39m

$649

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

5:47 am-1:41 pm

1 stop6h 54m

Santo Domingo Las Americas

Thu 10/16

2:56 pm-10:30 pm

1 stop8h 34m

$664

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 10/8

5:47 am-1:41 pm

1 stop6h 54m

Santo Domingo Las Americas

Wed 10/15

2:56 pm-10:30 pm

1 stop8h 34m

$730

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/9

6:30 am-1:50 am

2 stops18h 20m

Santo Domingo Las Americas

Thu 10/16

5:45 am-9:50 pm

2 stops17h 05m

$764

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Des Moines to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santo Domingo?

Our data shows that Tuesday is the least expensive day to fly to Santo Domingo. Tickets to fly out on this day can be as low as $613. The most expensive day to fly to Santo Domingo is Friday, with ticket prices averaging around $823.

What is the cheapest time of day to depart on your flight to Santo Domingo?

The cheapest time of day to fly to Santo Domingo is in the afternoon when flights can be purchased for as low as $674. Try not to purchase tickets in the morning because they tend to be around $690. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Direct flights

None
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
Search flight deals

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 6h 54m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $524Free CancellationRating
7.9
7,977 reviews
Search Delta flights
American AirlinesPriceFrom $529Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

I’m not ready to book a flight from Des Moines to Santo Domingo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Santo Domingo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santo Domingo and let you know when they change.

An easier way to manage your Santo Domingo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 9/1
Mon 9/8
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the Dominican Republic