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Cheap flights from Des Moines to Santo Domingo from $246

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 7/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:35 am - 5:29 am
DSM
-
SDQ
20h 54m
1 stop
Multiple Airlines Logo
6:10 am - 1:50 pm
SDQ
-
DSM
8h 40m
1 stop
$594Multiple Airlines
Fri, Jun 5 - Fri, Jun 12
Multiple Airlines Logo
5:02 pm - 11:06 am
DSM
-
SDQ
17h 04m
1 stop
Multiple Airlines Logo
12:21 pm - 10:52 pm
SDQ
-
DSM
11h 31m
1 stop
$599Multiple Airlines
Sun, Jun 21 - Sun, Jun 28
Multiple Airlines Logo
7:35 am - 9:40 pm
DSM
-
SDQ
37h 05m
2 stops
Multiple Airlines Logo
6:10 am - 1:50 pm
SDQ
-
DSM
8h 40m
1 stop
$605Multiple Airlines
Fri, Jun 5 - Fri, Jun 12
Multiple Airlines Logo
10:01 pm - 10:53 am
DSM
-
SDQ
35h 52m
2 stops
Multiple Airlines Logo
12:18 pm - 9:27 pm
SDQ
-
DSM
10h 09m
1 stop
$612Multiple Airlines
Fri, Jul 3 - Thu, Jul 9
American Airlines Logo
4:48 pm - 9:24 am
DSM
-
SDQ
15h 36m
2 stops
American Airlines Logo
7:00 am - 6:22 pm
SDQ
-
DSM
12h 22m
2 stops
$665American Airlines
Fri, Jun 5 - Fri, Jun 12
American Airlines Logo
8:02 pm - 1:15 pm
DSM
-
SDQ
16h 13m
2 stops
American Airlines Logo
1:45 pm - 9:58 pm
SDQ
-
DSM
9h 13m
1 stop
$705American Airlines
Mon, Jun 1 - Tue, Jun 16
Multiple Airlines Logo
9:27 am - 10:15 pm
DSM
-
SDQ
11h 48m
2 stops
Multiple Airlines Logo
6:59 am - 1:50 pm
SDQ
-
DSM
31h 51m
1 stop
$712Multiple Airlines
Sun, Jun 21 - Sun, Jun 28
American Airlines Logo
1:30 pm - 12:45 pm
DSM
-
SDQ
22h 15m
1 stop
American Airlines Logo
1:45 pm - 9:58 pm
SDQ
-
DSM
9h 13m
1 stop
$713American Airlines
Mon, Jun 1 - Tue, Jun 16
American Airlines Logo
5:00 am - 9:25 pm
DSM
-
SDQ
15h 25m
2 stops
American Airlines Logo
10:27 am - 12:09 am
SDQ
-
DSM
14h 42m
2 stops
$730American Airlines
Fri, Jul 3 - Thu, Jul 9
United Airlines Logo
5:00 am - 10:46 pm
DSM
-
SDQ
16h 46m
2 stops
United Airlines Logo
3:20 pm - 10:20 am
SDQ
-
DSM
20h 00m
2 stops
$735United Airlines
Sat, Sep 26 - Tue, Sep 29

American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
Jun 5
DSM4:48 pmDes Moines
15h 36m
2 stops
SDQ9:24 amSanto Domingo Las Americas
Jun 12
SDQ7:00 amSanto Domingo Las Americas
12h 22m
2 stops
DSM6:22 pmDes Moines
$665
American Airlines
Jun 1
DSM8:02 pmDes Moines
16h 13m
2 stops
SDQ1:15 pmSanto Domingo Las Americas
Jun 16
SDQ1:45 pmSanto Domingo Las Americas
9h 13m
1 stop
DSM9:58 pmDes Moines
$705
American Airlines
Jun 1
DSM1:30 pmDes Moines
22h 15m
1 stop
SDQ12:45 pmSanto Domingo Las Americas
Jun 16
SDQ1:45 pmSanto Domingo Las Americas
9h 13m
1 stop
DSM9:58 pmDes Moines
$713

Delta flights from Des Moines to Santo Domingo

Our best Delta deals on Des Moines to Santo Domingo flight tickets
Delta
Jul 3
DSM5:35 amDes Moines
6h 41m
1 stop
SDQ1:16 pmSanto Domingo Las Americas
Jul 9
SDQ2:42 pmSanto Domingo Las Americas
8h 47m
1 stop
DSM10:29 pmDes Moines
$745
Delta
Jun 20
DSM5:35 amDes Moines
6h 41m
1 stop
SDQ1:16 pmSanto Domingo Las Americas
Jun 27
SDQ2:41 pmSanto Domingo Las Americas
8h 50m
1 stop
DSM10:31 pmDes Moines
$1,048

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 6/5

7:35 am-5:29 am

1 stop20h 54m

Santo Domingo Las Americas

Fri 6/12

6:10 am-1:50 pm

1 stop8h 40m

$594

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 6/21

5:02 pm-11:06 am

1 stop17h 04m

Santo Domingo Las Americas

Sun 6/28

12:21 pm-10:52 pm

1 stop11h 31m

$599

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 6/5

7:35 am-9:40 pm

2 stops37h 05m

Santo Domingo Las Americas

Fri 6/12

6:10 am-1:50 pm

1 stop8h 40m

$605

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 7/3

10:01 pm-10:53 am

2 stops35h 52m

Santo Domingo Las Americas

Thu 7/9

12:18 pm-9:27 pm

1 stop10h 09m

$612

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 6/5

4:48 pm-9:24 am

2 stops15h 36m

Santo Domingo Las Americas

Fri 6/12

7:00 am-6:22 pm

2 stops12h 22m

$665
Quickest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/1

8:02 pm-1:15 pm

2 stops16h 13m

Santo Domingo Las Americas

Tue 6/16

1:45 pm-9:58 pm

1 stop9h 13m

$705

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 6/21

9:27 am-10:15 pm

2 stops11h 48m

Santo Domingo Las Americas

Sun 6/28

6:59 am-1:50 pm

1 stop31h 51m

$712

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/1

1:30 pm-12:45 pm

1 stop22h 15m

Santo Domingo Las Americas

Tue 6/16

1:45 pm-9:58 pm

1 stop9h 13m

$713

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 7/3

5:00 am-9:25 pm

2 stops15h 25m

Santo Domingo Las Americas

Thu 7/9

10:27 am-12:09 am

2 stops14h 42m

$730

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sat 9/26

5:00 am-10:46 pm

2 stops16h 46m

Santo Domingo Las Americas

Tue 9/29

3:20 pm-10:20 am

2 stops20h 00m

$735

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Santo Domingo

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Can stopping save me money on Des Moines to Santo Domingo flights?

You could potentially save up to 15% on your flight if you consider stops on a Des Moines to Santo Domingo flight.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Fastest flight time

6h 57m

Direct flights

None
The fastest flight from Des Moines to Santo Domingo takes 6h 57m
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
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Frequently asked questions about flying from Des Moines to Santo Domingo

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 6h 57m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $514Free CancellationRating
7.9
8,454 reviews
Search Delta flights
American AirlinesPriceFrom $613Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

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If you are not ready to book a flight from Des Moines to Santo Domingo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santo Domingo and let you know when they change.

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