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Cheap flights from Des Moines to Santo Domingo from $231

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Santo Domingo departing on 4/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Santo Domingo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:30 am - 1:29 pm
DSM
-
SDQ
27h 59m
1 stop
Multiple Airlines Logo
2:35 pm - 4:00 pm
SDQ
-
DSM
26h 25m
1 stop
$430Multiple Airlines
Sun, Apr 19 - Wed, Apr 22
Multiple Airlines Logo
8:30 am - 1:29 pm
DSM
-
SDQ
27h 59m
1 stop
Multiple Airlines Logo
2:35 pm - 1:46 pm
SDQ
-
DSM
24h 11m
2 stops
$505Multiple Airlines
Sun, Apr 19 - Wed, Apr 22
Multiple Airlines Logo
7:45 am - 1:29 pm
DSM
-
SDQ
28h 44m
1 stop
Multiple Airlines Logo
2:35 pm - 10:57 pm
SDQ
-
DSM
33h 22m
2 stops
$522Multiple Airlines
Thu, May 7 - Thu, May 14
Multiple Airlines Logo
8:30 am - 1:29 pm
DSM
-
SDQ
27h 59m
1 stop
Multiple Airlines Logo
2:35 pm - 10:42 pm
SDQ
-
DSM
33h 07m
2 stops
$555Multiple Airlines
Sun, Apr 19 - Sun, Apr 26
American Airlines Logo
3:20 pm - 9:20 am
DSM
-
SDQ
17h 00m
2 stops
American Airlines Logo
6:00 am - 4:31 pm
SDQ
-
DSM
11h 31m
2 stops
$623American Airlines
Tue, May 5 - Tue, May 12
American Airlines Logo
5:00 am - 4:55 pm
DSM
-
SDQ
10h 55m
2 stops
American Airlines Logo
4:00 pm - 8:26 am
SDQ
-
DSM
17h 26m
2 stops
$626American Airlines
Wed, May 6 - Wed, May 13
American Airlines Logo
5:50 am - 10:55 pm
DSM
-
SDQ
16h 05m
1 stop
American Airlines Logo
1:45 pm - 9:58 pm
SDQ
-
DSM
9h 13m
1 stop
$629American Airlines
Mon, Jun 1 - Tue, Jun 16
American Airlines Logo
7:10 am - 10:55 pm
DSM
-
SDQ
14h 45m
2 stops
American Airlines Logo
7:35 pm - 12:52 pm
SDQ
-
DSM
18h 17m
2 stops
$633American Airlines
Mon, Jun 1 - Tue, Jun 16
Delta Logo
5:27 am - 1:24 pm
DSM
-
SDQ
6h 57m
1 stop
Delta Logo
2:49 pm - 10:32 pm
SDQ
-
DSM
8h 43m
1 stop
$639Delta
Thu, May 7 - Thu, May 14
American Airlines Logo
6:00 am - 10:55 pm
DSM
-
SDQ
15h 55m
2 stops
American Airlines Logo
5:55 pm - 1:11 pm
SDQ
-
DSM
20h 16m
2 stops
$640American Airlines
Thu, May 7 - Thu, May 14

American Airlines flights from Des Moines to Santo Domingo

Our best American Airlines deals on Des Moines to Santo Domingo flight tickets
American Airlines
May 5
DSM3:20 pmDes Moines
17h 00m
2 stops
SDQ9:20 amSanto Domingo Las Americas
May 12
SDQ6:00 amSanto Domingo Las Americas
11h 31m
2 stops
DSM4:31 pmDes Moines
$623
American Airlines
May 6
DSM5:00 amDes Moines
10h 55m
2 stops
SDQ4:55 pmSanto Domingo Las Americas
May 13
SDQ4:00 pmSanto Domingo Las Americas
17h 26m
2 stops
DSM8:26 amDes Moines
$626
American Airlines
Jun 1
DSM5:50 amDes Moines
16h 05m
1 stop
SDQ10:55 pmSanto Domingo Las Americas
Jun 16
SDQ1:45 pmSanto Domingo Las Americas
9h 13m
1 stop
DSM9:58 pmDes Moines
$629

Delta flights from Des Moines to Santo Domingo

Our best Delta deals on Des Moines to Santo Domingo flight tickets
Delta
May 7
DSM5:27 amDes Moines
6h 57m
1 stop
SDQ1:24 pmSanto Domingo Las Americas
May 14
SDQ2:49 pmSanto Domingo Las Americas
8h 43m
1 stop
DSM10:32 pmDes Moines
$639
Delta
May 8
DSM6:15 amDes Moines
10h 46m
2 stops
SDQ6:01 pmSanto Domingo Las Americas
May 15
SDQ7:35 pmSanto Domingo Las Americas
16h 33m
2 stops
DSM11:08 amDes Moines
$643
Delta
Apr 19
DSM6:10 amDes Moines
11h 24m
2 stops
SDQ6:34 pmSanto Domingo Las Americas
Apr 22
SDQ6:05 amSanto Domingo Las Americas
11h 57m
2 stops
DSM5:02 pmDes Moines
$673

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 4/19

8:30 am-1:29 pm

1 stop27h 59m

Santo Domingo Las Americas

Wed 4/22

2:35 pm-4:00 pm

1 stop26h 25m

$430

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 4/19

8:30 am-1:29 pm

1 stop27h 59m

Santo Domingo Las Americas

Wed 4/22

2:35 pm-1:46 pm

2 stops24h 11m

$505

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 5/7

7:45 am-1:29 pm

1 stop28h 44m

Santo Domingo Las Americas

Thu 5/14

2:35 pm-10:57 pm

2 stops33h 22m

$522

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sun 4/19

8:30 am-1:29 pm

1 stop27h 59m

Santo Domingo Las Americas

Sun 4/26

2:35 pm-10:42 pm

2 stops33h 07m

$555

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 5/5

3:20 pm-9:20 am

2 stops17h 00m

Santo Domingo Las Americas

Tue 5/12

6:00 am-4:31 pm

2 stops11h 31m

$623

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Wed 5/6

5:00 am-4:55 pm

2 stops10h 55m

Santo Domingo Las Americas

Wed 5/13

4:00 pm-8:26 am

2 stops17h 26m

$626

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/1

5:50 am-10:55 pm

1 stop16h 05m

Santo Domingo Las Americas

Tue 6/16

1:45 pm-9:58 pm

1 stop9h 13m

$629

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 6/1

7:10 am-10:55 pm

2 stops14h 45m

Santo Domingo Las Americas

Tue 6/16

7:35 pm-12:52 pm

2 stops18h 17m

$633
Quickest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 5/7

5:27 am-1:24 pm

1 stop6h 57m

Santo Domingo Las Americas

Thu 5/14

2:49 pm-10:32 pm

1 stop8h 43m

$639

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 5/7

6:00 am-10:55 pm

2 stops15h 55m

Santo Domingo Las Americas

Thu 5/14

5:55 pm-1:11 pm

2 stops20h 16m

$640

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Santo Domingo from

How to get the cheapest flight ticket from Des Moines to Santo Domingo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Santo Domingo?

Can stopping save me money on Des Moines to Santo Domingo flights?

You could potentially save up to 23% on your flight if you consider stops on a Des Moines to Santo Domingo flight.

When to book flights from Des Moines to Santo Domingo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Santo Domingo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Santo Domingo (DSM to SDQ) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Santo Domingo

Fastest flight time

6h 35m

Direct flights

None
The fastest flight from Des Moines to Santo Domingo takes 6h 35m
There are no direct flights from Des Moines to Santo Domingo. There are no popular flight routes from Des Moines to Santo Domingo.
Search flight deals

  • How far is Des Moines to Santo Domingo Las Americas by plane?

    There are 2118.5 mi between Des Moines and Santo Domingo Las Americas. By plane, this route typically takes 6h 35m.

  • When did momondo last update prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

    Prices for flights from Des Moines Airport to Santo Domingo Las Americas Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Santo Domingo Las Americas Airport?

  • How old do you have to be to fly from Des Moines Airport to Santo Domingo Las Americas Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Santo Domingo Las Americas Airport.

  • What documentation or ID do you need to fly to Santo Domingo Las Americas Airport?

    The necessary travel and health documents for your Santo Domingo Las Americas Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Santo Domingo?

Best airlines flying from Des Moines to Santo Domingo

Compare and see reviews for airlines that fly from Des Moines to Santo Domingo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $514Free CancellationRating
7.9
8,327 reviews
Search Delta flights
American AirlinesPriceFrom $613Free CancellationRating
7.1
11,493 reviews
Search American Airlines flights

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Santo Domingo?

It is quick and easy to find Des Moines to Santo Domingo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Santo Domingo that suits you.

Can I find flights from Des Moines to Santo Domingo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santo Domingo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Santo Domingo?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Des Moines to Santo Domingo.

I’m not ready to book a flight from Des Moines to Santo Domingo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Santo Domingo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Santo Domingo and let you know when they change.

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