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Cheap flights from Des Moines to Illinois from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Illinois departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Illinois

Cheap round-trip flights

Southwest Logo
8:25 am - 9:30 amDSM-STL
1h 05mnonstop
Southwest Logo
9:15 pm - 10:20 pmSTL-DSM
1h 05mnonstop
$97Southwest
Find Deal
Wed, Aug 27 - Wed, Sep 3
Southwest Logo
4:35 pm - 5:40 pmDSM-STL
1h 05mnonstop
Southwest Logo
8:10 am - 2:40 pmSTL-DSM
6h 30m1 stop
$107Southwest
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
4:20 pm - 8:32 pmDSM-STL
4h 12m1 stop
American Airlines Logo
3:59 pm - 11:13 pmSTL-DSM
7h 14m1 stop
$158American Airlines
Find Deal
Sat, Sep 13 - Sat, Sep 20
United Airlines Logo
11:35 am - 3:44 pmDSM-STL
4h 09m1 stop
United Airlines Logo
6:35 am - 12:14 pmSTL-DSM
5h 39m1 stop
$159United Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
6:12 pm - 10:50 pmDSM-STL
4h 38m1 stop
American Airlines Logo
7:16 am - 1:07 pmSTL-DSM
5h 51m1 stop
$165American Airlines
Find Deal
Thu, Sep 4 - Sat, Sep 6
United Airlines Logo
6:50 pm - 8:25 pmDSM-ORD
1h 35mnonstop
United Airlines Logo
1:00 pm - 2:20 pmORD-DSM
1h 20mnonstop
$194United Airlines
Find Deal
Mon, Aug 18 - Sat, Sep 6
Frontier Logo
3:30 pm - 9:07 amDSM-STL
17h 37m1 stop
Frontier Logo
7:52 pm - 7:59 pmSTL-DSM
24h 07m1 stop
$195Frontier
Find Deal
Wed, Oct 15 - Sun, Oct 19
Logo
5:49 pm - 10:43 amDSM-ORD
16h 54m2 stops
Logo
6:44 pm - 4:59 pmORD-DSM
22h 15m2 stops
$195
Find Deal
Sun, Sep 7 - Wed, Sep 10
Frontier Logo
3:23 pm - 10:37 amDSM-ORD
19h 14m1 stop
Frontier Logo
6:00 am - 2:23 pmORD-DSM
8h 23m1 stop
$197Frontier
Find Deal
Thu, Aug 21 - Sun, Aug 24
Logo
8:25 am - 9:18 amDSM-ORD
24h 53m2 stops
Logo
5:17 pm - 9:24 amORD-DSM
16h 07m1 stop
$218
Find Deal
Mon, Sep 22 - Tue, Sep 23

United Airlines flights from Des Moines to Illinois

Our best United Airlines deals on Des Moines to Illinois flight tickets
United Airlines
Aug 27
DSM11:35 amDes Moines
4h 09m
1 stop
STL3:44 pmLambert-St Louis
Sep 3
STL6:35 amLambert-St Louis
5h 39m
1 stop
DSM12:14 pmDes Moines
$159
Find similar
United Airlines
Aug 18
DSM6:50 pmDes Moines
1h 35m
ORD8:25 pmChicago O'Hare Intl
Sep 6
ORD1:00 pmChicago O'Hare Intl
1h 20m
DSM2:20 pmDes Moines
$194
Find similar
United Airlines
Aug 21
DSM11:35 amDes Moines
1h 34m
ORD1:09 pmChicago O'Hare Intl
Aug 24
ORD9:12 amChicago O'Hare Intl
1h 27m
DSM10:39 amDes Moines
$241
Find similar

Frontier flights from Des Moines to Illinois

Our best Frontier deals on Des Moines to Illinois flight tickets
Frontier
Oct 15
DSM3:30 pmDes Moines
17h 37m
1 stop
STL9:07 amLambert-St Louis
Oct 19
STL7:52 pmLambert-St Louis
24h 07m
1 stop
DSM7:59 pmDes Moines
$195
Find similar
Frontier
Aug 21
DSM3:23 pmDes Moines
19h 14m
1 stop
ORD10:37 amChicago O'Hare Intl
Aug 24
ORD6:00 amChicago O'Hare Intl
8h 23m
1 stop
DSM2:23 pmDes Moines
$197
Find similar
Frontier
Sep 15
DSM2:25 pmDes Moines
9h 34m
1 stop
ORD11:59 pmChicago O'Hare Intl
Sep 18
ORD6:00 amChicago O'Hare Intl
7h 40m
1 stop
DSM1:40 pmDes Moines
$198
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Illinois that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to Illinois that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 8/27

8:25 am-9:30 am

Nonstop1h 05m

Lambert-St Louis

Wed 9/3

9:15 pm-10:20 pm

Nonstop1h 05m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 8/27

4:35 pm-5:40 pm

Nonstop1h 05m

Lambert-St Louis

Wed 9/3

8:10 am-2:40 pm

1 stop6h 30m

$107

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/13

4:20 pm-8:32 pm

1 stop4h 12m

Lambert-St Louis

Sat 9/20

3:59 pm-11:13 pm

1 stop7h 14m

$158

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 8/27

11:35 am-3:44 pm

1 stop4h 09m

Lambert-St Louis

Wed 9/3

6:35 am-12:14 pm

1 stop5h 39m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/4

6:12 pm-10:50 pm

1 stop4h 38m

Lambert-St Louis

Sat 9/6

7:16 am-1:07 pm

1 stop5h 51m

$165

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Mon 8/18

6:50 pm-8:25 pm

Nonstop1h 35m

Chicago O'Hare Intl

Sat 9/6

1:00 pm-2:20 pm

Nonstop1h 20m

$194

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/15

3:30 pm-9:07 am

1 stop17h 37m

Lambert-St Louis

Sun 10/19

7:52 pm-7:59 pm

1 stop24h 07m

$195

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sun 9/7

5:49 pm-10:43 am

2 stops16h 54m

Chicago O'Hare Intl

Wed 9/10

6:44 pm-4:59 pm

2 stops22h 15m

$195

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 8/21

3:23 pm-10:37 am

1 stop19h 14m

Chicago O'Hare Intl

Sun 8/24

6:00 am-2:23 pm

1 stop8h 23m

$197

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Mon 9/22

8:25 am-9:18 am

2 stops24h 53m

Chicago O'Hare Intl

Tue 9/23

5:17 pm-9:24 am

1 stop16h 07m

$218

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Illinois from

How to get the cheapest flight ticket from Des Moines to Illinois

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Illinois?

The cheapest month to fly to Illinois from Des Moines is in May. Flight prices, which tend to average around $224, are often lower during this time because this is during the off-season. If you aren’t able to travel to Illinois during the month of May, then flying in September is also cheap. Prices for this month can be found on momondo for an average of $229.

What is the cheapest day to depart on your flight to Illinois?

The cheapest day to depart from Des Moines to Illinois is on a Friday when prices can be found for as low as $571. Flights from Des Moines to Illinois on a Tuesday will generally be more expensive and average around $840. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Illinois?

Our most recent data shows that the best time of day to fly to Illinois is in the morning. Flights from Des Moines to Illinois during this time can be as low as $559. Flights at noon are often more expensive with an average ticket price of $1,156.

What is the cheapest Des Moines to Illinois flight route?

Fly from Des Moines to Chicago O'Hare Intl for the best Des Moines - Illinois flight prices

How far in advance should I book a flight to Illinois?

You are more likely to see cheaper flights to Illinois from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Illinois for around $256 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Illinois from Des Moines for as low as $186 on momondo.

What cabin class options are available on Des Moines to Illinois flights?

There are 4 cabin classes available to choose from on Des Moines to Illinois flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Illinois flights?

You could potentially save up to 58% on your flight if you consider stops on a Des Moines to Illinois flight.

Cheap Des Moines to Illinois flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Illinois

Best Price Found

$49

Fastest flight time

1h 05m

Direct flights

Every day

Airports in Illinois

3 airports
The best one-way flight to Illinois from Des Moines in the past 72 hours is $49. The best round-trip flight deal from Des Moines to Illinois found on momondo in the last 72 hours is $97.
The fastest flight from Des Moines to Illinois takes 1h 05m
Direct flights go from Des Moines to Illinois every day.
There are 3 airports near Illinois: Chicago O'Hare Intl (ORD), Chicago Midway (MDW), Lambert-St Louis (STL)
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Illinois?

    Prices for flights from Des Moines Airport to Illinois refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Illinois?

  • How old do you have to be to fly from Des Moines Airport to Illinois?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Illinois.

  • What documentation or ID do you need to fly to Illinois?

    The necessary travel and health documents for your Illinois trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Illinois?

Best airlines flying from Des Moines to Illinois

Compare and see reviews for airlines that fly from Des Moines to Illinois with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $180Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Illinois?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Illinois. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Illinois with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Illinois flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Illinois?

momondo helps you find the best flight between Des Moines and Illinois by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Illinois right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Des Moines to Illinois now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Illinois and let you know when they change.

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