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Cheap flights from Des Moines to Columbia from $274

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Columbia departing on 9/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Columbia

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:10 pm - 11:49 pm-
6h 39m
Delta Logo
6:00 am - 10:46 am-
5h 46m
$295Delta
Sat, Sep 12 - Sat, Sep 19
American Airlines Logo
5:56 pm - 12:03 am-
5h 07m
American Airlines Logo
6:47 pm - 11:41 pm-
5h 54m
$295American Airlines
Wed, Sep 9 - Fri, Sep 11
American Airlines Logo
5:56 pm - 12:03 am-
5h 07m
American Airlines Logo
6:47 pm - 11:41 pm-
5h 54m
$297American Airlines
Wed, Sep 16 - Wed, Sep 23
American Airlines Logo
2:21 pm - 10:52 pm-
7h 31m
American Airlines Logo
6:46 pm - 11:44 pm-
5h 58m
$307American Airlines
Tue, Aug 25 - Tue, Sep 8
United Airlines Logo
6:00 am - 2:21 pm-
7h 21m
United Airlines Logo
6:25 am - 10:31 am-
5h 06m
$312United Airlines
Tue, Aug 25 - Tue, Sep 8
United Airlines Logo
8:00 am - 1:40 pm-
4h 40m
United Airlines Logo
10:22 am - 5:28 pm-
8h 06m
$337United Airlines
Sat, Sep 12 - Sat, Sep 19
United Airlines Logo
5:45 am - 5:03 pm-
10h 18m
United Airlines Logo
10:22 am - 5:28 pm-
8h 06m
$342United Airlines
Sat, Sep 12 - Sat, Sep 19
Delta Logo
5:40 am - 11:09 am-
4h 29m
Delta Logo
11:57 am - 3:15 pm-
4h 18m
$359Delta
Mon, Aug 24 - Tue, Sep 8
Delta Logo
5:40 am - 1:14 pm-
6h 34m
Delta Logo
7:30 am - 10:46 am-
4h 16m
$359Delta
Wed, Aug 26 - Tue, Sep 8
Delta Logo
5:40 am - 11:09 am-
4h 29m
Delta Logo
11:57 am - 3:15 pm-
4h 18m
$459Delta
Tue, Aug 25 - Tue, Sep 8

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American Airlines flights from Des Moines to Columbia

Our best American Airlines deals on Des Moines to Columbia flight tickets
American Airlines
Sep 9
DSM5:56 pmDes Moines
5h 07m
1 stop
CAE12:03 amColumbia Metropolitan
Sep 11
CAE6:47 pmColumbia Metropolitan
5h 54m
1 stop
DSM11:41 pmDes Moines
$295
American Airlines
Sep 16
DSM5:56 pmDes Moines
5h 07m
1 stop
CAE12:03 amColumbia Metropolitan
Sep 23
CAE6:47 pmColumbia Metropolitan
5h 54m
1 stop
DSM11:41 pmDes Moines
$297
American Airlines
Aug 25
DSM2:21 pmDes Moines
7h 31m
1 stop
CAE10:52 pmColumbia Metropolitan
Sep 8
CAE6:46 pmColumbia Metropolitan
5h 58m
1 stop
DSM11:44 pmDes Moines
$307

United Airlines flights from Des Moines to Columbia

Our best United Airlines deals on Des Moines to Columbia flight tickets
United Airlines
Aug 25
DSM6:00 amDes Moines
7h 21m
2 stops
CAE2:21 pmColumbia Metropolitan
Sep 8
CAE6:25 amColumbia Metropolitan
5h 06m
1 stop
DSM10:31 amDes Moines
$312
United Airlines
Sep 12
DSM8:00 amDes Moines
4h 40m
1 stop
CAE1:40 pmColumbia Metropolitan
Sep 19
CAE10:22 amColumbia Metropolitan
8h 06m
2 stops
DSM5:28 pmDes Moines
$337
United Airlines
Sep 12
DSM5:45 amDes Moines
10h 18m
2 stops
CAE5:03 pmColumbia Metropolitan
Sep 19
CAE10:22 amColumbia Metropolitan
8h 06m
2 stops
DSM5:28 pmDes Moines
$342

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Des Moines to Columbia that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 9/12

4:10 pm-11:49 pm

1 stop6h 39m

Columbia Metropolitan

Sat 9/19

6:00 am-10:46 am

1 stop5h 46m

$295

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 9/9

5:56 pm-12:03 am

1 stop5h 07m

Columbia Metropolitan

Fri 9/11

6:47 pm-11:41 pm

1 stop5h 54m

$295

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 9/16

5:56 pm-12:03 am

1 stop5h 07m

Columbia Metropolitan

Wed 9/23

6:47 pm-11:41 pm

1 stop5h 54m

$297

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 8/25

2:21 pm-10:52 pm

1 stop7h 31m

Columbia Metropolitan

Tue 9/8

6:46 pm-11:44 pm

1 stop5h 58m

$307

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 8/25

6:00 am-2:21 pm

2 stops7h 21m

Columbia Metropolitan

Tue 9/8

6:25 am-10:31 am

1 stop5h 06m

$312

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 9/12

8:00 am-1:40 pm

1 stop4h 40m

Columbia Metropolitan

Sat 9/19

10:22 am-5:28 pm

2 stops8h 06m

$337

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 9/12

5:45 am-5:03 pm

2 stops10h 18m

Columbia Metropolitan

Sat 9/19

10:22 am-5:28 pm

2 stops8h 06m

$342
Quickest round-trip

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Mon 8/24

5:40 am-11:09 am

1 stop4h 29m

Columbia Metropolitan

Tue 9/8

11:57 am-3:15 pm

1 stop4h 18m

$359

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 8/26

5:40 am-1:14 pm

1 stop6h 34m

Columbia Metropolitan

Tue 9/8

7:30 am-10:46 am

1 stop4h 16m

$359

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 8/25

5:40 am-11:09 am

1 stop4h 29m

Columbia Metropolitan

Tue 9/8

11:57 am-3:15 pm

1 stop4h 18m

$459

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Columbia

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Columbia?

The cheapest month to fly to Columbia from Des Moines is in November. Flight prices, which tend to average around $0, are often lower during this time because this is during the off-season. If you’re not able to fly to Columbia in November, then February is your next best option. Flight prices from Des Moines to Columbia during February average around $0.

When to book flights from Des Moines to Columbia

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Columbia according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Columbia (DSM to CAE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Columbia

Fastest flight time

4h 52m

Direct flights

None
The fastest flight from Des Moines to Columbia takes 4h 52m
There are no direct flights from Des Moines to Columbia. There are no popular flight routes from Des Moines to Columbia.
Search flight deals

Frequently asked questions about flying from Des Moines to Columbia

  • How far is Des Moines to Columbia Metropolitan by plane?

    There are 862.4 mi between Des Moines and Columbia Metropolitan. By plane, this route typically takes 4h 52m.

  • When did momondo last update prices for flights from Des Moines Airport to Columbia Metropolitan Airport?

    Prices for flights from Des Moines Airport to Columbia Metropolitan Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Columbia Metropolitan Airport?

  • How old do you have to be to fly from Des Moines Airport to Columbia Metropolitan Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Columbia Metropolitan Airport.

  • What documentation or ID do you need to fly to Columbia Metropolitan Airport?

    The travel and health documents required for your trip to Columbia Metropolitan Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Columbia Metropolitan Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Columbia?

Best airlines flying from Des Moines to Columbia

Compare and see reviews for airlines that fly from Des Moines to Columbia with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.8
8,483 reviews
Search Delta flights
American AirlinesPriceFrom $296Free CancellationRating
7.1
11,845 reviews
Search American Airlines flights

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Orangeburg
Lexington
West Columbia
Irmo
Swansea

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Columbia?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbia from Des Moines.

Can I find flights from Des Moines to Columbia with flexible booking policies on momondo?

All flight searches from Des Moines to Columbia on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Columbia?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Columbia from Des Moines.

I’m not ready to book a flight from Des Moines to Columbia right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Columbia, momondo offers a useful price alert feature which will track prices for flights to Columbia from Des Moines and alert you when they change.

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