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Cheap flights from Des Moines to Columbia from $157

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Columbia departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Columbia

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:50 pm - 8:10 pm
DSM
-
CAE
5h 20m
1 stop
American Airlines Logo
4:15 pm - 11:59 pm
CAE
-
DSM
8h 44m
1 stop
$325American Airlines
Sat, Apr 11 - Sat, Apr 18
American Airlines Logo
1:50 pm - 8:10 pm
DSM
-
CAE
5h 20m
1 stop
American Airlines Logo
4:15 pm - 11:59 pm
CAE
-
DSM
8h 44m
1 stop
$326American Airlines
Sat, Apr 11 - Sat, Apr 18
American Airlines Logo
1:50 pm - 8:10 pm
DSM
-
CAE
5h 20m
1 stop
American Airlines Logo
10:49 am - 7:33 pm
CAE
-
DSM
9h 44m
2 stops
$330American Airlines
Sat, Apr 11 - Sat, Apr 18
American Airlines Logo
1:50 pm - 8:10 pm
DSM
-
CAE
5h 20m
1 stop
American Airlines Logo
5:00 am - 1:46 pm
CAE
-
DSM
9h 46m
2 stops
$331American Airlines
Sat, Apr 11 - Sat, Apr 18
United Airlines Logo
5:00 am - 1:41 pm
DSM
-
CAE
7h 41m
1 stop
United Airlines Logo
6:30 am - 10:37 am
CAE
-
DSM
5h 07m
1 stop
$339United Airlines
Sat, May 2 - Wed, May 6
United Airlines Logo
11:40 am - 11:59 pm
DSM
-
CAE
11h 19m
2 stops
United Airlines Logo
6:30 am - 10:37 am
CAE
-
DSM
5h 07m
1 stop
$344United Airlines
Sat, May 2 - Wed, May 6
United Airlines Logo
1:35 pm - 11:59 pm
DSM
-
CAE
9h 24m
2 stops
United Airlines Logo
10:34 am - 8:16 pm
CAE
-
DSM
10h 42m
2 stops
$349United Airlines
Sat, May 2 - Wed, May 6
Delta Logo
7:35 am - 3:40 pm
DSM
-
CAE
7h 05m
1 stop
Delta Logo
4:28 pm - 10:38 pm
CAE
-
DSM
7h 10m
1 stop
$354Delta
Thu, Mar 5 - Mon, Mar 9
United Airlines Logo
10:02 am - 7:03 pm
DSM
-
CAE
8h 01m
2 stops
United Airlines Logo
10:34 am - 8:16 pm
CAE
-
DSM
10h 42m
2 stops
$399United Airlines
Sat, May 2 - Wed, May 6
United Airlines Logo
8:00 am - 2:56 pm
DSM
-
CAE
5h 56m
1 stop
United Airlines Logo
6:15 am - 4:07 pm
CAE
-
DSM
10h 52m
2 stops
$412United Airlines
Thu, Mar 5 - Mon, Mar 9

Delta flights from Des Moines to Columbia

Our best Delta deals on Des Moines to Columbia flight tickets
Delta
Mar 5
DSM7:35 amDes Moines
7h 05m
1 stop
CAE3:40 pmColumbia Metropolitan
Mar 9
CAE4:28 pmColumbia Metropolitan
7h 10m
1 stop
DSM10:38 pmDes Moines
$354
Delta
Apr 5
DSM5:20 pmDes Moines
5h 28m
1 stop
CAE11:48 pmColumbia Metropolitan
Apr 7
CAE5:34 amColumbia Metropolitan
6h 14m
1 stop
DSM10:48 amDes Moines
$497
Delta
Mar 22
DSM5:20 pmDes Moines
5h 28m
1 stop
CAE11:48 pmColumbia Metropolitan
Mar 28
CAE9:58 amColumbia Metropolitan
7h 56m
2 stops
DSM4:54 pmDes Moines
$499

American Airlines flights from Des Moines to Columbia

Our best American Airlines deals on Des Moines to Columbia flight tickets
American Airlines
Apr 11
DSM1:50 pmDes Moines
5h 20m
1 stop
CAE8:10 pmColumbia Metropolitan
Apr 18
CAE4:15 pmColumbia Metropolitan
8h 44m
1 stop
DSM11:59 pmDes Moines
$325
American Airlines
Apr 11
DSM1:50 pmDes Moines
5h 20m
1 stop
CAE8:10 pmColumbia Metropolitan
Apr 18
CAE4:15 pmColumbia Metropolitan
8h 44m
1 stop
DSM11:59 pmDes Moines
$326
American Airlines
Apr 11
DSM1:50 pmDes Moines
5h 20m
1 stop
CAE8:10 pmColumbia Metropolitan
Apr 18
CAE10:49 amColumbia Metropolitan
9h 44m
2 stops
DSM7:33 pmDes Moines
$330

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Des Moines to Columbia that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 4/11

1:50 pm-8:10 pm

1 stop5h 20m

Columbia Metropolitan

Sat 4/18

4:15 pm-11:59 pm

1 stop8h 44m

$325

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 4/11

1:50 pm-8:10 pm

1 stop5h 20m

Columbia Metropolitan

Sat 4/18

4:15 pm-11:59 pm

1 stop8h 44m

$326

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 4/11

1:50 pm-8:10 pm

1 stop5h 20m

Columbia Metropolitan

Sat 4/18

10:49 am-7:33 pm

2 stops9h 44m

$330

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 4/11

1:50 pm-8:10 pm

1 stop5h 20m

Columbia Metropolitan

Sat 4/18

5:00 am-1:46 pm

2 stops9h 46m

$331

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 5/2

5:00 am-1:41 pm

1 stop7h 41m

Columbia Metropolitan

Wed 5/6

6:30 am-10:37 am

1 stop5h 07m

$339

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 5/2

11:40 am-11:59 pm

2 stops11h 19m

Columbia Metropolitan

Wed 5/6

6:30 am-10:37 am

1 stop5h 07m

$344

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 5/2

1:35 pm-11:59 pm

2 stops9h 24m

Columbia Metropolitan

Wed 5/6

10:34 am-8:16 pm

2 stops10h 42m

$349

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 3/5

7:35 am-3:40 pm

1 stop7h 05m

Columbia Metropolitan

Mon 3/9

4:28 pm-10:38 pm

1 stop7h 10m

$354

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 5/2

10:02 am-7:03 pm

2 stops8h 01m

Columbia Metropolitan

Wed 5/6

10:34 am-8:16 pm

2 stops10h 42m

$399

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 3/5

8:00 am-2:56 pm

1 stop5h 56m

Columbia Metropolitan

Mon 3/9

6:15 am-4:07 pm

2 stops10h 52m

$412

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Columbia from

How to get the cheapest flight ticket from Des Moines to Columbia

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Columbia Metropolitan?

United Airlines and Delta are the most popular carriers operating from Des Moines to Columbia Metropolitan

What airlines fly to Columbia?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Columbia from Des Moines according to our data. American Airlines is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Columbia. Keep in mind that there are 3 different airlines that fly to Columbia on a routine basis, so you have a few additional options to choose from.

When to book flights from Des Moines to Columbia

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Columbia according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Columbia (DSM to CAE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Columbia

Fastest flight time

5h 28m

Direct flights

None
The fastest flight from Des Moines to Columbia takes 5h 28m
There are no direct flights from Des Moines to Columbia. There are no popular flight routes from Des Moines to Columbia.
Search flight deals

  • How far is Des Moines to Columbia Metropolitan by plane?

    There are 862.4 mi between Des Moines and Columbia Metropolitan. By plane, this route typically takes 5h 28m.

  • When did momondo last update prices for flights from Des Moines Airport to Columbia Metropolitan Airport?

    Prices for flights from Des Moines Airport to Columbia Metropolitan Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Columbia Metropolitan Airport?

  • How old do you have to be to fly from Des Moines Airport to Columbia Metropolitan Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Columbia Metropolitan Airport.

  • What documentation or ID do you need to fly to Columbia Metropolitan Airport?

    The travel and health documents required for your trip to Columbia Metropolitan Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Columbia Metropolitan Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Columbia?

Best airlines flying from Des Moines to Columbia

Compare and see reviews for airlines that fly from Des Moines to Columbia with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,367 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,245 reviews
Search Delta flights

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Orangeburg
Lexington
West Columbia
Irmo
Swansea

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Columbia?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbia from Des Moines.

Can I find flights from Des Moines to Columbia with flexible booking policies on momondo?

All flight searches from Des Moines to Columbia on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Columbia?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Columbia from Des Moines.

I’m not ready to book a flight from Des Moines to Columbia right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Columbia, momondo offers a useful price alert feature which will track prices for flights to Columbia from Des Moines and alert you when they change.

An easier way to manage your Columbia trip

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