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Cheap flights from Des Moines to Columbia from $299

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Columbia departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Columbia

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:37 pm - 9:59 pm
DSM
-
CAE
7h 22m
1 stop
American Airlines Logo
3:25 pm - 8:43 pm
CAE
-
DSM
6h 18m
1 stop
$299American Airlines
Thu, May 28 - Thu, Jun 4
Delta Logo
6:41 pm - 11:46 pm
DSM
-
CAE
4h 05m
1 stop
Delta Logo
7:17 pm - 10:32 pm
CAE
-
DSM
4h 15m
1 stop
$300Delta
Wed, May 27 - Sun, May 31
Delta Logo
6:41 pm - 11:49 pm
DSM
-
CAE
4h 08m
1 stop
Delta Logo
7:17 pm - 10:32 pm
CAE
-
DSM
4h 15m
1 stop
$347Delta
Fri, May 22 - Mon, May 25
Delta Logo
5:27 am - 1:14 pm
DSM
-
CAE
6h 47m
1 stop
Delta Logo
5:38 am - 11:08 am
CAE
-
DSM
6h 30m
1 stop
$354Delta
Sun, May 10 - Sun, May 17
American Airlines Logo
5:00 am - 2:05 pm
DSM
-
CAE
8h 05m
2 stops
American Airlines Logo
7:21 pm - 11:57 pm
CAE
-
DSM
5h 36m
1 stop
$358American Airlines
Wed, May 27 - Mon, Jun 1
American Airlines Logo
6:02 am - 2:05 pm
DSM
-
CAE
7h 03m
2 stops
American Airlines Logo
3:25 pm - 8:43 pm
CAE
-
DSM
6h 18m
1 stop
$368American Airlines
Thu, May 28 - Thu, Jun 4
United Airlines Logo
5:00 am - 2:16 pm
DSM
-
CAE
8h 16m
2 stops
United Airlines Logo
6:25 am - 10:22 am
CAE
-
DSM
4h 57m
1 stop
$371United Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
7:10 am - 3:25 pm
DSM
-
CAE
7h 15m
1 stop
American Airlines Logo
8:30 pm - 12:10 am
CAE
-
DSM
4h 40m
1 stop
$398American Airlines
Tue, Jun 9 - Sun, Jun 14
United Airlines Logo
8:04 am - 2:49 pm
DSM
-
CAE
5h 45m
1 stop
United Airlines Logo
10:34 am - 7:26 pm
CAE
-
DSM
9h 52m
2 stops
$424United Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
5:00 am - 2:05 pm
DSM
-
CAE
8h 05m
2 stops
American Airlines Logo
6:03 pm - 12:08 am
CAE
-
DSM
7h 05m
2 stops
$462American Airlines
Wed, May 27 - Mon, Jun 1

American Airlines flights from Des Moines to Columbia

Our best American Airlines deals on Des Moines to Columbia flight tickets
American Airlines
May 28
DSM1:37 pmDes Moines
7h 22m
1 stop
CAE9:59 pmColumbia Metropolitan
Jun 4
CAE3:25 pmColumbia Metropolitan
6h 18m
1 stop
DSM8:43 pmDes Moines
$299
American Airlines
May 27
DSM5:00 amDes Moines
8h 05m
2 stops
CAE2:05 pmColumbia Metropolitan
Jun 1
CAE7:21 pmColumbia Metropolitan
5h 36m
1 stop
DSM11:57 pmDes Moines
$358
American Airlines
May 28
DSM6:02 amDes Moines
7h 03m
2 stops
CAE2:05 pmColumbia Metropolitan
Jun 4
CAE3:25 pmColumbia Metropolitan
6h 18m
1 stop
DSM8:43 pmDes Moines
$368

United Airlines flights from Des Moines to Columbia

Our best United Airlines deals on Des Moines to Columbia flight tickets
United Airlines
May 27
DSM5:00 amDes Moines
8h 16m
2 stops
CAE2:16 pmColumbia Metropolitan
May 31
CAE6:25 amColumbia Metropolitan
4h 57m
1 stop
DSM10:22 amDes Moines
$371
United Airlines
Apr 23
DSM5:30 amDes Moines
10h 25m
2 stops
CAE4:55 pmColumbia Metropolitan
May 9
CAE2:20 pmColumbia Metropolitan
6h 06m
1 stop
DSM7:26 pmDes Moines
$389
United Airlines
Apr 28
DSM8:04 amDes Moines
5h 45m
1 stop
CAE2:49 pmColumbia Metropolitan
May 2
CAE10:34 amColumbia Metropolitan
9h 52m
2 stops
DSM7:26 pmDes Moines
$424

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Des Moines to Columbia that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 5/28

1:37 pm-9:59 pm

1 stop7h 22m

Columbia Metropolitan

Thu 6/4

3:25 pm-8:43 pm

1 stop6h 18m

$299
Quickest round-trip

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 5/27

6:41 pm-11:46 pm

1 stop4h 05m

Columbia Metropolitan

Sun 5/31

7:17 pm-10:32 pm

1 stop4h 15m

$300

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 5/22

6:41 pm-11:49 pm

1 stop4h 08m

Columbia Metropolitan

Mon 5/25

7:17 pm-10:32 pm

1 stop4h 15m

$347

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sun 5/10

5:27 am-1:14 pm

1 stop6h 47m

Columbia Metropolitan

Sun 5/17

5:38 am-11:08 am

1 stop6h 30m

$354

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 5/27

5:00 am-2:05 pm

2 stops8h 05m

Columbia Metropolitan

Mon 6/1

7:21 pm-11:57 pm

1 stop5h 36m

$358

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 5/28

6:02 am-2:05 pm

2 stops7h 03m

Columbia Metropolitan

Thu 6/4

3:25 pm-8:43 pm

1 stop6h 18m

$368

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 5/27

5:00 am-2:16 pm

2 stops8h 16m

Columbia Metropolitan

Sun 5/31

6:25 am-10:22 am

1 stop4h 57m

$371

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 6/9

7:10 am-3:25 pm

1 stop7h 15m

Columbia Metropolitan

Sun 6/14

8:30 pm-12:10 am

1 stop4h 40m

$398

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 4/28

8:04 am-2:49 pm

1 stop5h 45m

Columbia Metropolitan

Sat 5/2

10:34 am-7:26 pm

2 stops9h 52m

$424

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 5/27

5:00 am-2:05 pm

2 stops8h 05m

Columbia Metropolitan

Mon 6/1

6:03 pm-12:08 am

2 stops7h 05m

$462

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Columbia from

How to get the cheapest flight ticket from Des Moines to Columbia

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Columbia?

When to book flights from Des Moines to Columbia

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Columbia according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Columbia (DSM to CAE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Columbia

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Des Moines to Columbia takes 4h 05m
There are no direct flights from Des Moines to Columbia. There are no popular flight routes from Des Moines to Columbia.
Search flight deals

Frequently asked questions about flying from Des Moines to Columbia

  • How far is Des Moines to Columbia Metropolitan by plane?

    There are 862.4 mi between Des Moines and Columbia Metropolitan. By plane, this route typically takes 4h 05m.

  • When did momondo last update prices for flights from Des Moines Airport to Columbia Metropolitan Airport?

    Prices for flights from Des Moines Airport to Columbia Metropolitan Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Columbia Metropolitan Airport?

  • How old do you have to be to fly from Des Moines Airport to Columbia Metropolitan Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Columbia Metropolitan Airport.

  • What documentation or ID do you need to fly to Columbia Metropolitan Airport?

    The travel and health documents required for your trip to Columbia Metropolitan Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Columbia Metropolitan Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Columbia?

Best airlines flying from Des Moines to Columbia

Compare and see reviews for airlines that fly from Des Moines to Columbia with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,580 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,404 reviews
Search Delta flights

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Orangeburg
Lexington
West Columbia
Irmo
Swansea

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Columbia?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbia from Des Moines.

Can I find flights from Des Moines to Columbia with flexible booking policies on momondo?

All flight searches from Des Moines to Columbia on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Columbia?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Columbia from Des Moines.

I’m not ready to book a flight from Des Moines to Columbia right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Columbia, momondo offers a useful price alert feature which will track prices for flights to Columbia from Des Moines and alert you when they change.

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