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Cheap flights from Des Moines to Columbia from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Columbia departing on 11/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Columbia

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:07 am - 2:15 pmDSM-CAE
7h 08m1 stop
American Airlines Logo
8:00 pm - 12:21 amCAE-DSM
5h 21m1 stop
$254American Airlines
Find Deal
Thu, Oct 30 - Sun, Nov 2
American Airlines Logo
7:06 am - 3:33 pmDSM-CAE
7h 27m1 stop
American Airlines Logo
3:02 pm - 9:13 pmCAE-DSM
7h 11m1 stop
$259American Airlines
Find Deal
Fri, Oct 31 - Sat, Nov 1
American Airlines Logo
5:00 am - 3:04 pmDSM-CAE
9h 04m2 stops
American Airlines Logo
8:00 pm - 12:21 amCAE-DSM
5h 21m1 stop
$284American Airlines
Find Deal
Thu, Oct 30 - Sun, Nov 2
Delta Logo
5:15 pm - 11:54 pmDSM-CAE
5h 39m1 stop
Delta Logo
5:40 am - 10:23 amCAE-DSM
5h 43m1 stop
$294Delta
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
11:32 am - 7:16 pmDSM-CAE
6h 44m1 stop
American Airlines Logo
10:10 am - 3:45 pmCAE-DSM
6h 35m1 stop
$296American Airlines
Find Deal
Wed, Dec 24 - Thu, Jan 8
Delta Logo
10:15 am - 5:58 pmDSM-CAE
6h 43m2 stops
Delta Logo
5:40 am - 10:23 amCAE-DSM
5h 43m1 stop
$299Delta
Find Deal
Wed, Mar 25 - Sat, Mar 28
United Airlines Logo
3:15 pm - 9:30 pmDSM-CAE
5h 15m1 stop
United Airlines Logo
5:24 pm - 9:32 pmCAE-DSM
5h 08m1 stop
$329United Airlines
Find Deal
Fri, Oct 31 - Sat, Nov 1
United Airlines Logo
3:15 pm - 9:30 pmDSM-CAE
5h 15m1 stop
United Airlines Logo
10:34 am - 11:44 pmCAE-DSM
14h 10m2 stops
$334United Airlines
Find Deal
Fri, Oct 31 - Sat, Nov 1
United Airlines Logo
3:15 pm - 9:05 pmDSM-CAE
4h 50m1 stop
United Airlines Logo
5:25 pm - 9:36 pmCAE-DSM
5h 11m1 stop
$349United Airlines
Find Deal
Fri, Apr 3 - Tue, Apr 7
Delta Logo
6:20 am - 5:58 pmDSM-CAE
10h 38m2 stops
Delta Logo
6:50 pm - 10:28 pmCAE-DSM
4h 38m1 stop
$363Delta
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Thu, Feb 26 - Mon, Mar 2

American Airlines flights from Des Moines to Columbia

Our best American Airlines deals on Des Moines to Columbia flight tickets
American Airlines
Oct 30
DSM6:07 amDes Moines
7h 08m
1 stop
CAE2:15 pmColumbia Metropolitan
Nov 2
CAE8:00 pmColumbia Metropolitan
5h 21m
1 stop
DSM12:21 amDes Moines
$254
Find similar
American Airlines
Oct 31
DSM7:06 amDes Moines
7h 27m
1 stop
CAE3:33 pmColumbia Metropolitan
Nov 1
CAE3:02 pmColumbia Metropolitan
7h 11m
1 stop
DSM9:13 pmDes Moines
$259
Find similar
American Airlines
Oct 30
DSM5:00 amDes Moines
9h 04m
2 stops
CAE3:04 pmColumbia Metropolitan
Nov 2
CAE8:00 pmColumbia Metropolitan
5h 21m
1 stop
DSM12:21 amDes Moines
$284
Find similar

Delta flights from Des Moines to Columbia

Our best Delta deals on Des Moines to Columbia flight tickets
Delta
Mar 25
DSM5:15 pmDes Moines
5h 39m
1 stop
CAE11:54 pmColumbia Metropolitan
Mar 28
CAE5:40 amColumbia Metropolitan
5h 43m
1 stop
DSM10:23 amDes Moines
$294
Find similar
Delta
Mar 25
DSM10:15 amDes Moines
8h 59m
2 stops
CAE8:14 pmColumbia Metropolitan
Mar 28
CAE5:40 amColumbia Metropolitan
5h 43m
1 stop
DSM10:23 amDes Moines
$299
Find similar
Delta
Feb 26
DSM6:20 amDes Moines
10h 38m
2 stops
CAE5:58 pmColumbia Metropolitan
Mar 2
CAE6:50 pmColumbia Metropolitan
4h 38m
1 stop
DSM10:28 pmDes Moines
$363
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Des Moines to Columbia that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 10/30

6:07 am-2:15 pm

1 stop7h 08m

Columbia Metropolitan

Sun 11/2

8:00 pm-12:21 am

1 stop5h 21m

$254

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 10/31

7:06 am-3:33 pm

1 stop7h 27m

Columbia Metropolitan

Sat 11/1

3:02 pm-9:13 pm

1 stop7h 11m

$259

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 10/30

5:00 am-3:04 pm

2 stops9h 04m

Columbia Metropolitan

Sun 11/2

8:00 pm-12:21 am

1 stop5h 21m

$284

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 3/25

5:15 pm-11:54 pm

1 stop5h 39m

Columbia Metropolitan

Sat 3/28

5:40 am-10:23 am

1 stop5h 43m

$294

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 12/24

11:32 am-7:16 pm

1 stop6h 44m

Columbia Metropolitan

Thu 1/8

10:10 am-3:45 pm

1 stop6h 35m

$296

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 3/25

10:15 am-5:58 pm

2 stops6h 43m

Columbia Metropolitan

Sat 3/28

5:40 am-10:23 am

1 stop5h 43m

$299

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 10/31

3:15 pm-9:30 pm

1 stop5h 15m

Columbia Metropolitan

Sat 11/1

5:24 pm-9:32 pm

1 stop5h 08m

$329

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 10/31

3:15 pm-9:30 pm

1 stop5h 15m

Columbia Metropolitan

Sat 11/1

10:34 am-11:44 pm

2 stops14h 10m

$334

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 4/3

3:15 pm-9:05 pm

1 stop4h 50m

Columbia Metropolitan

Tue 4/7

5:25 pm-9:36 pm

1 stop5h 11m

$349

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 2/26

6:20 am-5:58 pm

2 stops10h 38m

Columbia Metropolitan

Mon 3/2

6:50 pm-10:28 pm

1 stop4h 38m

$363

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Columbia from

How to get the cheapest flight ticket from Des Moines to Columbia

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Columbia?

The cheapest month to fly to Columbia from Des Moines is in August. Flight prices, which tend to average around $248, are often lower during this time because this is during the off-season. If you’re not able to fly to Columbia in August, then February is your next best option. Flight prices from Des Moines to Columbia during February average around $316.

What is the cheapest day to depart on your flight to Columbia?

On average, the least expensive day to fly to Columbia from Des Moines is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $258. However, this price may fluctuate depending on the airline, the season, and holidays. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Columbia on Monday is $422.

What is the cheapest time of day to depart on your flight to Columbia?

In the afternoon is the cheapest time of day to fly from Des Moines to Columbia when you can find flight prices for as low as $321. Flying to Columbia in the afternoon is an ideal time because this is during off-peak travel hours. Flights at noon are often more expensive with an average ticket price of $386.

When to book flights from Des Moines to Columbia

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Columbia according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Columbia (DSM to CAE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Columbia

Direct flights

None
There are no direct flights from Des Moines to Columbia. There are no popular flight routes from Des Moines to Columbia.
Search flight deals

  • How far is Des Moines to Columbia Metropolitan by plane?

    There are 862.4 mi between Des Moines and Columbia Metropolitan. By plane, this route typically takes 4h 17m.

  • When did momondo last update prices for flights from Des Moines Airport to Columbia Metropolitan Airport?

    Prices for flights from Des Moines Airport to Columbia Metropolitan Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Columbia Metropolitan Airport?

  • How old do you have to be to fly from Des Moines Airport to Columbia Metropolitan Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Columbia Metropolitan Airport.

  • What documentation or ID do you need to fly to Columbia Metropolitan Airport?

    The travel and health documents required for your trip to Columbia Metropolitan Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Columbia Metropolitan Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Columbia?

Best airlines flying from Des Moines to Columbia

Compare and see reviews for airlines that fly from Des Moines to Columbia with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
7,975 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Columbia?

Book flights to Columbia if you plan to visit one of these locations
Orangeburg
Lexington
West Columbia
Irmo
Swansea

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Columbia?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Columbia from Des Moines.

Can I find flights from Des Moines to Columbia with flexible booking policies on momondo?

All flight searches from Des Moines to Columbia on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Columbia?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Columbia from Des Moines.

I’m not ready to book a flight from Des Moines to Columbia right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Columbia, momondo offers a useful price alert feature which will track prices for flights to Columbia from Des Moines and alert you when they change.

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