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Cheap flights from Des Moines to Cleveland from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Cleveland departing on 11/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Cleveland

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:32 pm - 11:51 pmDSM-CLE
8h 19m1 stop
Frontier Logo
6:00 am - 1:56 pmCLE-DSM
8h 56m1 stop
$218Frontier
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Fri, Oct 31 - Thu, Nov 6
Multiple Airlines Logo
8:30 am - 12:22 pmDSM-CLE
26h 52m2 stops
Multiple Airlines Logo
6:00 am - 1:56 pmCLE-DSM
8h 56m1 stop
$261Multiple Airlines
Find Deal
Fri, Oct 31 - Thu, Nov 6
American Airlines Logo
6:00 am - 12:05 pmDSM-CLE
5h 05m1 stop
American Airlines Logo
8:35 pm - 11:50 pmCLE-DSM
4h 15m1 stop
$292American Airlines
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Fri, Oct 31 - Fri, Nov 7
American Airlines Logo
6:00 am - 3:19 pmDSM-CLE
8h 19m2 stops
American Airlines Logo
4:15 pm - 11:30 pmCLE-DSM
8h 15m1 stop
$297American Airlines
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Fri, Oct 31 - Fri, Nov 7
Delta Logo
4:59 pm - 11:29 pmDSM-CLE
5h 30m1 stop
Delta Logo
5:22 am - 9:41 amCLE-DSM
5h 19m1 stop
$357Delta
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Fri, Nov 14 - Sun, Nov 16
United Airlines Logo
3:15 pm - 10:01 pmDSM-CLE
5h 46m1 stop
United Airlines Logo
8:40 am - 12:14 pmCLE-DSM
4h 34m1 stop
$402United Airlines
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Mon, Oct 27 - Fri, Oct 31
United Airlines Logo
1:05 pm - 6:25 pmDSM-CLE
4h 20m1 stop
United Airlines Logo
6:00 am - 2:20 pmCLE-DSM
9h 20m2 stops
$407United Airlines
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Wed, Nov 26 - Wed, Dec 3
Southwest Logo
6:25 am - 5:15 pmDSM-CLE
9h 50m2 stops
Southwest Logo
3:25 pm - 11:35 pmCLE-DSM
9h 10m2 stops
$423Southwest
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Fri, Oct 31 - Thu, Nov 6
Delta Logo
5:56 pm - 10:16 pmDSM-CLE
3h 20m1 stop
Delta Logo
7:05 am - 10:26 amCLE-DSM
4h 21m1 stop
$427Delta
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Tue, Oct 28 - Sat, Nov 1
Southwest Logo
10:15 am - 9:55 pmDSM-CLE
10h 40m2 stops
Southwest Logo
5:00 am - 10:00 amCLE-DSM
6h 00m2 stops
$458Southwest
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Tue, Oct 28 - Sun, Nov 2

American Airlines flights from Des Moines to Cleveland

Our best American Airlines deals on Des Moines to Cleveland flight tickets
American Airlines
Oct 31
DSM6:00 amDes Moines
5h 05m
1 stop
CLE12:05 pmCleveland Hopkins Intl
Nov 7
CLE8:35 pmCleveland Hopkins Intl
4h 15m
1 stop
DSM11:50 pmDes Moines
$292
Find similar
American Airlines
Oct 31
DSM6:00 amDes Moines
8h 19m
2 stops
CLE3:19 pmCleveland Hopkins Intl
Nov 7
CLE4:15 pmCleveland Hopkins Intl
8h 15m
1 stop
DSM11:30 pmDes Moines
$297
Find similar

Delta flights from Des Moines to Cleveland

Our best Delta deals on Des Moines to Cleveland flight tickets
Delta
Nov 14
DSM4:59 pmDes Moines
5h 30m
1 stop
CLE11:29 pmCleveland Hopkins Intl
Nov 16
CLE5:22 amCleveland Hopkins Intl
5h 19m
1 stop
DSM9:41 amDes Moines
$357
Find similar
Delta
Oct 28
DSM5:56 pmDes Moines
3h 20m
1 stop
CLE10:16 pmCleveland Hopkins Intl
Nov 1
CLE7:05 amCleveland Hopkins Intl
4h 21m
1 stop
DSM10:26 amDes Moines
$427
Find similar
Delta
Nov 14
DSM2:45 pmDes Moines
8h 12m
2 stops
CLE11:57 pmCleveland Hopkins Intl
Nov 16
CLE5:22 amCleveland Hopkins Intl
5h 58m
2 stops
DSM10:20 amDes Moines
$1,434
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cleveland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Des Moines to Cleveland that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 10/31

2:32 pm-11:51 pm

1 stop8h 19m

Cleveland Hopkins Intl

Thu 11/6

6:00 am-1:56 pm

1 stop8h 56m

$218

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 10/31

8:30 am-12:22 pm

2 stops26h 52m

Cleveland Hopkins Intl

Thu 11/6

6:00 am-1:56 pm

1 stop8h 56m

$261

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 10/31

6:00 am-12:05 pm

1 stop5h 05m

Cleveland Hopkins Intl

Fri 11/7

8:35 pm-11:50 pm

1 stop4h 15m

$292

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 10/31

6:00 am-3:19 pm

2 stops8h 19m

Cleveland Hopkins Intl

Fri 11/7

4:15 pm-11:30 pm

1 stop8h 15m

$297

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 11/14

4:59 pm-11:29 pm

1 stop5h 30m

Cleveland Hopkins Intl

Sun 11/16

5:22 am-9:41 am

1 stop5h 19m

$357

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Mon 10/27

3:15 pm-10:01 pm

1 stop5h 46m

Cleveland Hopkins Intl

Fri 10/31

8:40 am-12:14 pm

1 stop4h 34m

$402

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Wed 11/26

1:05 pm-6:25 pm

1 stop4h 20m

Cleveland Hopkins Intl

Wed 12/3

6:00 am-2:20 pm

2 stops9h 20m

$407

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 10/31

6:25 am-5:15 pm

2 stops9h 50m

Cleveland Hopkins Intl

Thu 11/6

3:25 pm-11:35 pm

2 stops9h 10m

$423

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Tue 10/28

5:56 pm-10:16 pm

1 stop3h 20m

Cleveland Hopkins Intl

Sat 11/1

7:05 am-10:26 am

1 stop4h 21m

$427

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Tue 10/28

10:15 am-9:55 pm

2 stops10h 40m

Cleveland Hopkins Intl

Sun 11/2

5:00 am-10:00 am

2 stops6h 00m

$458

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Cleveland

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Cleveland?

In general, September is the cheapest month to fly from Des Moines to Cleveland. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $316. If you’re not able to fly to Cleveland in September, then April is your next best option. Flight prices from Des Moines to Cleveland during April average around $341.

What is the cheapest day to depart on your flight to Cleveland?

The cheapest day to depart from Des Moines to Cleveland is on a Tuesday when prices can be found for as low as $325. Be sure to avoid booking your departure on a Monday as prices are generally higher than usual. According to our data, the average ticket price to Cleveland on Monday is $518.

What is the cheapest time of day to depart on your flight to Cleveland?

Our data shows that the cheapest Des Moines to Cleveland flights are usually those with departure times in the evening. Our users have found flights to Cleveland in the evening for as low as $192. In contrast, the most expensive time of day to depart to Cleveland is in the morning when prices are around $408.

When to book flights from Des Moines to Cleveland

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Cleveland according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Cleveland (DSM to CLE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cleveland

Direct flights

None
There are no direct flights from Des Moines to Cleveland. There are no popular flight routes from Des Moines to Cleveland.
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  • How far is Des Moines to Cleveland Hopkins Intl by plane?

    The distance between Des Moines and Cleveland Hopkins Intl is about 616.3 mi. Flights usually cover this in 3h 20m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Cleveland Hopkins Intl Airport.

  • What documentation or ID do you need to fly to Cleveland Hopkins Intl Airport?

    The travel and health documents required for your trip to Cleveland Hopkins Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Cleveland Hopkins Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Cleveland?

Best airlines flying from Des Moines to Cleveland

Compare and see reviews for airlines that fly from Des Moines to Cleveland with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $256Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
SouthwestPriceFrom $281Free CancellationRating
8.0
4,238 reviews
Search Southwest flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
8,976 reviews
Search United Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
7,975 reviews
Search Delta flights

Traveling to a place near Cleveland?

Book flights to Cleveland if you plan to visit one of these locations
Sandusky
Beachwood
Mansfield
Elyria
Geneva-on-the-Lake
Mentor
Independence
Westlake
Wooster
Kent
Willoughby
North Olmsted
Streetsboro
Ashland
Cuyahoga Falls
Medina
Lakewood
Painesville
Kelleys Island
Avon

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cleveland?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Cleveland. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Cleveland with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Cleveland flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Cleveland?

momondo helps you find the best flight between Des Moines and Cleveland by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cleveland right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Cleveland flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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