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Cheap flights from Des Moines to Cleveland from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Cleveland departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Cleveland

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:16 pm - 11:52 am
DSM
-
CLE
20h 36m
1 stop
Frontier Logo
12:08 pm - 1:31 pm
CLE
-
DSM
26h 23m
1 stop
$141Frontier
Fri, May 15 - Thu, May 21
Frontier Logo
2:16 pm - 11:52 am
DSM
-
CLE
20h 36m
1 stop
Frontier Logo
12:47 pm - 1:31 pm
CLE
-
DSM
25h 44m
1 stop
$220Frontier
Fri, May 8 - Sun, May 10
Multiple Airlines Logo
6:00 am - 11:07 pm
DSM
-
CLE
16h 07m
1 stop
Multiple Airlines Logo
7:24 pm - 3:15 pm
CLE
-
DSM
20h 51m
2 stops
$228Multiple Airlines
Mon, May 11 - Wed, May 13
Multiple Airlines Logo
7:45 am - 11:50 am
DSM
-
CLE
27h 05m
2 stops
Multiple Airlines Logo
8:07 pm - 12:59 pm
CLE
-
DSM
17h 52m
1 stop
$249Multiple Airlines
Sun, May 10 - Tue, May 19
Multiple Airlines Logo
2:16 pm - 11:42 am
DSM
-
CLE
20h 26m
1 stop
Multiple Airlines Logo
8:07 pm - 12:59 pm
CLE
-
DSM
17h 52m
1 stop
$251Multiple Airlines
Mon, May 11 - Tue, May 19
Multiple Airlines Logo
7:45 am - 2:44 pm
DSM
-
CLE
29h 59m
1 stop
Multiple Airlines Logo
8:07 pm - 12:59 pm
CLE
-
DSM
17h 52m
1 stop
$252Multiple Airlines
Sun, May 10 - Tue, May 19
Delta Logo
5:56 pm - 10:20 pm
DSM
-
CLE
3h 24m
1 stop
Delta Logo
6:00 am - 10:16 am
CLE
-
DSM
5h 16m
1 stop
$257Delta
Tue, May 12 - Wed, May 20
Delta Logo
6:15 am - 1:23 pm
DSM
-
CLE
6h 08m
1 stop
Delta Logo
6:00 am - 10:16 am
CLE
-
DSM
5h 16m
1 stop
$263Delta
Tue, May 12 - Tue, May 19
Multiple Airlines Logo
10:30 am - 9:41 pm
DSM
-
CLE
10h 11m
1 stop
Multiple Airlines Logo
8:07 pm - 12:59 pm
CLE
-
DSM
17h 52m
1 stop
$264Multiple Airlines
Wed, May 13 - Tue, May 19
Multiple Airlines Logo
10:30 am - 7:32 pm
DSM
-
CLE
32h 02m
2 stops
Multiple Airlines Logo
8:07 pm - 12:59 pm
CLE
-
DSM
17h 52m
1 stop
$265Multiple Airlines
Wed, May 13 - Tue, May 19

Frontier flights from Des Moines to Cleveland

Our best Frontier deals on Des Moines to Cleveland flight tickets
Frontier
May 15
DSM2:16 pmDes Moines
20h 36m
1 stop
CLE11:52 amCleveland Hopkins Intl
May 21
CLE12:08 pmCleveland Hopkins Intl
26h 23m
1 stop
DSM1:31 pmDes Moines
$141
Frontier
May 8
DSM2:16 pmDes Moines
20h 36m
1 stop
CLE11:52 amCleveland Hopkins Intl
May 10
CLE12:47 pmCleveland Hopkins Intl
25h 44m
1 stop
DSM1:31 pmDes Moines
$220

Delta flights from Des Moines to Cleveland

Our best Delta deals on Des Moines to Cleveland flight tickets
Delta
May 12
DSM5:56 pmDes Moines
3h 24m
1 stop
CLE10:20 pmCleveland Hopkins Intl
May 20
CLE6:00 amCleveland Hopkins Intl
5h 16m
1 stop
DSM10:16 amDes Moines
$257
Delta
May 12
DSM6:15 amDes Moines
6h 08m
1 stop
CLE1:23 pmCleveland Hopkins Intl
May 19
CLE6:00 amCleveland Hopkins Intl
5h 16m
1 stop
DSM10:16 amDes Moines
$263
Delta
May 11
DSM5:28 pmDes Moines
4h 42m
1 stop
CLE11:10 pmCleveland Hopkins Intl
May 20
CLE6:35 amCleveland Hopkins Intl
4h 11m
1 stop
DSM9:46 amDes Moines
$290

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cleveland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Des Moines to Cleveland that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 5/15

2:16 pm-11:52 am

1 stop20h 36m

Cleveland Hopkins Intl

Thu 5/21

12:08 pm-1:31 pm

1 stop26h 23m

$141

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Fri 5/8

2:16 pm-11:52 am

1 stop20h 36m

Cleveland Hopkins Intl

Sun 5/10

12:47 pm-1:31 pm

1 stop25h 44m

$220

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Mon 5/11

6:00 am-11:07 pm

1 stop16h 07m

Cleveland Hopkins Intl

Wed 5/13

7:24 pm-3:15 pm

2 stops20h 51m

$228

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Sun 5/10

7:45 am-11:50 am

2 stops27h 05m

Cleveland Hopkins Intl

Tue 5/19

8:07 pm-12:59 pm

1 stop17h 52m

$249

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Mon 5/11

2:16 pm-11:42 am

1 stop20h 26m

Cleveland Hopkins Intl

Tue 5/19

8:07 pm-12:59 pm

1 stop17h 52m

$251

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Sun 5/10

7:45 am-2:44 pm

1 stop29h 59m

Cleveland Hopkins Intl

Tue 5/19

8:07 pm-12:59 pm

1 stop17h 52m

$252
Quickest round-trip

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Tue 5/12

5:56 pm-10:20 pm

1 stop3h 24m

Cleveland Hopkins Intl

Wed 5/20

6:00 am-10:16 am

1 stop5h 16m

$257

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Tue 5/12

6:15 am-1:23 pm

1 stop6h 08m

Cleveland Hopkins Intl

Tue 5/19

6:00 am-10:16 am

1 stop5h 16m

$263

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Wed 5/13

10:30 am-9:41 pm

1 stop10h 11m

Cleveland Hopkins Intl

Tue 5/19

8:07 pm-12:59 pm

1 stop17h 52m

$264

Des MoinesCleveland

DSM - CLE

DSMCLE

Des Moines

Wed 5/13

10:30 am-7:32 pm

2 stops32h 02m

Cleveland Hopkins Intl

Tue 5/19

8:07 pm-12:59 pm

1 stop17h 52m

$265

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Cleveland from

How to get the cheapest flight ticket from Des Moines to Cleveland

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

How have Des Moines to Cleveland flight prices changed over time?

As of April 2026, prices for Des Moines to Cleveland flights are approximately 112% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Cleveland

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Cleveland according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Cleveland (DSM to CLE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cleveland

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Des Moines to Cleveland takes 3h 55m
There are no direct flights from Des Moines to Cleveland. There are no popular flight routes from Des Moines to Cleveland.
Search flight deals

Frequently asked questions about flying from Des Moines to Cleveland

  • How far is Des Moines to Cleveland Hopkins Intl by plane?

    The distance between Des Moines and Cleveland Hopkins Intl is about 616.3 mi. Flights usually cover this in 3h 55m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Cleveland Hopkins Intl Airport.

  • What documentation or ID do you need to fly to Cleveland Hopkins Intl Airport?

    The travel and health documents required for your trip to Cleveland Hopkins Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Cleveland Hopkins Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Cleveland?

Best airlines flying from Des Moines to Cleveland

Compare and see reviews for airlines that fly from Des Moines to Cleveland with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $108Free CancellationRating
7.9
8,430 reviews
Search Delta flights
SouthwestPriceFrom $256Free CancellationRating
8.0
4,330 reviews
Search Southwest flights
American AirlinesPriceFrom $256Free CancellationRating
7.1
11,647 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
9,625 reviews
Search United Airlines flights

Traveling to a place near Cleveland?

Book flights to Cleveland if you plan to visit one of these locations
Sandusky
Mansfield
Beachwood
Independence
Elyria
Westlake
Mentor
Geneva-on-the-Lake
Kent
Painesville
Willoughby
Streetsboro
Cuyahoga Falls
Lakewood
Wooster
Kelleys Island
Avon
North Olmsted
Medina
Ashland

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cleveland?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Cleveland. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Cleveland with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Cleveland flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Cleveland?

momondo helps you find the best flight between Des Moines and Cleveland by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cleveland right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Cleveland flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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