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Cheap flights from Des Moines to Cleveland from $182

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Cleveland departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Cleveland

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
2:40 pm - 8:25 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 45m1 stop Chicago Midway
Southwest Logo
7:15 pm - 10:00 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
3h 45m1 stop Chicago Midway
$238Southwest
Wed, Sep 23 - Wed, Sep 30
Southwest Logo
2:40 pm - 8:25 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 45m1 stop Chicago Midway
Southwest Logo
12:50 pm - 9:05 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
9h 15m2 stops Chicago Midway Denver Intl
$243Southwest
Wed, Sep 23 - Wed, Sep 30
Multiple Airlines Logo
1:02 pm - 6:19 amDSM  Des Moines-CLE Cleveland Hopkins Intl
16h 17m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
3:45 pm - 2:42 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
23h 57m2 stops Atlanta Hartsfield-Jackson Philadelphia
$277Multiple Airlines
Mon, Oct 5 - Wed, Oct 7
Delta Logo
6:00 am - 1:40 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
6h 40m1 stop Detroit Metropolitan Wayne County
Delta Logo
11:00 am - 3:16 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
5h 16m1 stop Atlanta Hartsfield-Jackson
$309Delta
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
11:32 am - 5:11 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 39m1 stop Chicago O'Hare Intl
United Airlines Logo
7:00 am - 12:20 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
6h 20m1 stop Chicago O'Hare Intl
$322United Airlines
Wed, Sep 2 - Mon, Sep 7
United Airlines Logo
8:00 am - 1:13 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 13m1 stop Chicago O'Hare Intl
United Airlines Logo
7:00 am - 12:20 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
6h 20m1 stop Chicago O'Hare Intl
$322United Airlines
Tue, Sep 1 - Thu, Sep 3
Delta Logo
6:00 am - 1:40 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
6h 40m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:30 am - 9:38 amCLE  Cleveland Hopkins Intl-DSM Des Moines
4h 08m1 stop Detroit Metropolitan Wayne County
$322Delta
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
7:33 am - 2:20 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
5h 47m1 stop Chicago O'Hare Intl
American Airlines Logo
1:04 pm - 7:21 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
7h 17m1 stop Chicago O'Hare Intl
$322American Airlines
Sat, Sep 5 - Sat, Sep 12
Delta Logo
2:58 pm - 8:46 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:00 pm - 6:05 pmCLE  Cleveland Hopkins Intl-DSM Des Moines
6h 05m1 stop Atlanta Hartsfield-Jackson
$335Delta
Thu, Dec 3 - Mon, Dec 7
American Airlines Logo
6:55 am - 12:21 pmDSM  Des Moines-CLE Cleveland Hopkins Intl
4h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
8:44 pm - 12:20 amCLE  Cleveland Hopkins Intl-DSM Des Moines
4h 36m1 stop Chicago O'Hare Intl
$355American Airlines
Fri, Aug 28 - Tue, Sep 1

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United Airlines flights from Des Moines to Cleveland

Our best United Airlines deals on Des Moines to Cleveland flight tickets
United Airlines
Sep 1
DSM8:00 amDes Moines
4h 13m
1 stop
CLE1:13 pmCleveland Hopkins Intl
Sep 3
CLE7:00 amCleveland Hopkins Intl
6h 20m
1 stop
DSM12:20 pmDes Moines
$322
United Airlines
Sep 6
DSM6:00 amDes Moines
6h 09m
1 stop
CLE1:09 pmCleveland Hopkins Intl
Sep 13
CLE6:08 pmCleveland Hopkins Intl
4h 20m
1 stop
DSM9:28 pmDes Moines
$353
United Airlines
Aug 24
DSM6:00 amDes Moines
4h 16m
1 stop
CLE11:16 amCleveland Hopkins Intl
Aug 27
CLE8:23 amCleveland Hopkins Intl
6h 53m
1 stop
DSM2:16 pmDes Moines
$368

Southwest flights from Des Moines to Cleveland

Our best Southwest deals on Des Moines to Cleveland flight tickets
Southwest
Sep 23
DSM2:40 pmDes Moines
4h 45m
1 stop
CLE8:25 pmCleveland Hopkins Intl
Sep 30
CLE7:15 pmCleveland Hopkins Intl
3h 45m
1 stop
DSM10:00 pmDes Moines
$238
Southwest
Sep 23
DSM2:40 pmDes Moines
4h 45m
1 stop
CLE8:25 pmCleveland Hopkins Intl
Sep 30
CLE12:50 pmCleveland Hopkins Intl
9h 15m
2 stops
DSM9:05 pmDes Moines
$243
Southwest
Sep 23
DSM6:10 amDes Moines
6h 00m
2 stops
CLE1:10 pmCleveland Hopkins Intl
Sep 30
CLE12:50 pmCleveland Hopkins Intl
9h 15m
2 stops
DSM9:05 pmDes Moines
$311

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Cleveland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Des Moines to Cleveland that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Wed 9/23

2:40 pm-8:25 pm

1 stop4h 45m

Cleveland Hopkins Intl

Wed 9/30

7:15 pm-10:00 pm

1 stop3h 45m

$238

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Wed 9/23

2:40 pm-8:25 pm

1 stop4h 45m

Cleveland Hopkins Intl

Wed 9/30

12:50 pm-9:05 pm

2 stops9h 15m

$243

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Mon 10/5

1:02 pm-6:19 am

1 stop16h 17m

Cleveland Hopkins Intl

Wed 10/7

3:45 pm-2:42 pm

2 stops23h 57m

$277

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Sat 8/29

6:00 am-1:40 pm

1 stop6h 40m

Cleveland Hopkins Intl

Tue 9/1

11:00 am-3:16 pm

1 stop5h 16m

$309

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Wed 9/2

11:32 am-5:11 pm

1 stop4h 39m

Cleveland Hopkins Intl

Mon 9/7

7:00 am-12:20 pm

1 stop6h 20m

$322

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Tue 9/1

8:00 am-1:13 pm

1 stop4h 13m

Cleveland Hopkins Intl

Thu 9/3

7:00 am-12:20 pm

1 stop6h 20m

$322

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Wed 9/2

6:00 am-1:40 pm

1 stop6h 40m

Cleveland Hopkins Intl

Wed 9/9

6:30 am-9:38 am

1 stop4h 08m

$322

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Sat 9/5

7:33 am-2:20 pm

1 stop5h 47m

Cleveland Hopkins Intl

Sat 9/12

1:04 pm-7:21 pm

1 stop7h 17m

$322

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Thu 12/3

2:58 pm-8:46 pm

1 stop4h 48m

Cleveland Hopkins Intl

Mon 12/7

1:00 pm-6:05 pm

1 stop6h 05m

$335

Des MoinesCleveland

DSM Des Moines - CLE Cleveland Hopkins Intl

DSMCLE

Des Moines

Fri 8/28

6:55 am-12:21 pm

1 stop4h 26m

Cleveland Hopkins Intl

Tue 9/1

8:44 pm-12:20 am

1 stop4h 36m

$355

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Cleveland from

How to get the cheapest flight ticket from Des Moines to Cleveland

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Cleveland?

Prices are currently low for flights on this route.

Typical prices usually range from $550 to $803.
The lowest price recently found on this route was $238.

What is the cheapest month to fly to Cleveland?

In general, January is the cheapest month to fly from Des Moines to Cleveland. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you’re not able to fly to Cleveland in January, then November is your next best option. Flight prices from Des Moines to Cleveland during November average around $296.

How have Des Moines to Cleveland flight prices changed over time?

As of August 2026, prices for Des Moines to Cleveland flights are approximately 2% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to Cleveland

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Cleveland according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Cleveland (DSM to CLE) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Cleveland

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from Des Moines to Cleveland takes 4h 15m
There are no direct flights from Des Moines to Cleveland. There are no popular flight routes from Des Moines to Cleveland.
Search flight deals

Frequently asked questions about flying from Des Moines to Cleveland

  • How far is Des Moines to Cleveland Hopkins Intl by plane?

    The distance between Des Moines and Cleveland Hopkins Intl is about 616.3 mi. Flights usually cover this in 4h 15m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Prices for flights from Des Moines Airport to Cleveland Hopkins Intl Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Cleveland Hopkins Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Cleveland Hopkins Intl Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Cleveland Hopkins Intl Airport.

  • What documentation or ID do you need to fly to Cleveland Hopkins Intl Airport?

    The travel and health documents required for your trip to Cleveland Hopkins Intl Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Cleveland Hopkins Intl Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Cleveland?

Best airlines flying from Des Moines to Cleveland

Compare and see reviews for airlines that fly from Des Moines to Cleveland with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $256Free CancellationRating
7.1
11,897 reviews
Search American Airlines flights
DeltaPriceFrom $296Free CancellationRating
7.8
8,497 reviews
Search Delta flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
10,095 reviews
Search United Airlines flights

Traveling to a place near Cleveland?

Book flights to Cleveland if you plan to visit one of these locations
Sandusky
Mansfield
Beachwood
Westlake
Mentor
Independence
Elyria
Kent
Willoughby
Geneva-on-the-Lake
Painesville
Medina
Wooster
Macedonia
Streetsboro
Lakewood
Strongsville
Avon
North Olmsted
Ashland

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Cleveland?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Cleveland. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Cleveland with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Cleveland flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Cleveland?

momondo helps you find the best flight between Des Moines and Cleveland by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Cleveland right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Cleveland flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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