What is the cheapest airline that flies from Des Moines to Buffalo?

Delta, Southwest, and American Airlines are the most popular carriers operating from Des Moines to Buffalo

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

As of November 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Buffalo Airport.

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$174 Cheap Flights from Des Moines to Buffalo in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Buffalo

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Cheap round-trip flights

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6:09 am - 11:24 amDSM Des Moines-BUF Buffalo

4h 15m1 stop Detroit Metropolitan Wayne County

6:10 am - 9:50 amBUF Buffalo-DSM Des Moines

4h 40m1 stop Detroit Metropolitan Wayne County

$325Delta

Wed, Dec 9 - Wed, Dec 16

5:24 am - 11:42 amDSM Des Moines-BUF Buffalo

5h 18m1 stop Washington, D.C. Reagan-National

4:21 pm - 12:33 amBUF Buffalo-DSM Des Moines

9h 12m2 stops Boston Logan Intl Chicago O'Hare Intl

$330American Airlines

Wed, Dec 9 - Wed, Dec 16

9:23 am - 6:00 pmDSM Des Moines-BUF Buffalo

7h 37m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National

4:21 pm - 12:33 amBUF Buffalo-DSM Des Moines

9h 12m2 stops Boston Logan Intl Chicago O'Hare Intl

$335American Airlines

Wed, Dec 9 - Wed, Dec 16

6:09 am - 11:24 amDSM Des Moines-BUF Buffalo

4h 15m1 stop Detroit Metropolitan Wayne County

6:10 am - 9:50 amBUF Buffalo-DSM Des Moines

4h 40m1 stop Detroit Metropolitan Wayne County

$347Delta

Wed, Dec 9 - Wed, Dec 16

5:24 am - 11:42 amDSM Des Moines-BUF Buffalo

5h 18m1 stop Washington, D.C. Reagan-National

4:21 pm - 12:33 amBUF Buffalo-DSM Des Moines

9h 12m2 stops Boston Logan Intl Chicago O'Hare Intl

$352American Airlines

Wed, Dec 9 - Wed, Dec 16

2:05 pm - 11:11 pmDSM Des Moines-BUF Buffalo

8h 06m2 stops Chicago O'Hare Intl Boston Logan Intl

5:26 am - 1:35 pmBUF Buffalo-DSM Des Moines

9h 09m2 stops New York LaGuardia Chicago O'Hare Intl

$357American Airlines

Wed, Dec 9 - Wed, Dec 16

1:23 pm - 10:57 pmDSM Des Moines-BUF Buffalo

8h 34m1 stop Denver Intl

6:30 am - 12:39 pmBUF Buffalo-DSM Des Moines

7h 09m1 stop Chicago O'Hare Intl

$425United Airlines

Mon, Dec 14 - Wed, Dec 16

1:15 pm - 11:34 pmDSM Des Moines-BUF Buffalo

9h 19m2 stops Chicago O'Hare Intl Newark

10:30 am - 2:14 pmBUF Buffalo-DSM Des Moines

4h 44m1 stop Chicago O'Hare Intl

$430United Airlines

Mon, Dec 14 - Wed, Dec 16

1:15 pm - 11:34 pmDSM Des Moines-BUF Buffalo

9h 19m2 stops Chicago O'Hare Intl Newark

11:23 am - 7:19 pmBUF Buffalo-DSM Des Moines

8h 56m2 stops Newark Chicago O'Hare Intl

$435United Airlines

Mon, Dec 14 - Wed, Dec 16

1:23 pm - 10:57 pmDSM Des Moines-BUF Buffalo

8h 34m1 stop Denver Intl

1:53 pm - 5:14 pmBUF Buffalo-DSM Des Moines

4h 21m1 stop Chicago O'Hare Intl

$462United Airlines

Mon, Dec 14 - Wed, Dec 16

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United Airlines flights from Des Moines to Buffalo

Our best United Airlines deals on Des Moines to Buffalo flight tickets

United Airlines

Dec 14

DSM1:23 pmDes Moines

8h 34m

1 stop

BUF10:57 pmBuffalo

Dec 16

BUF6:30 amBuffalo

7h 09m

1 stop

DSM12:39 pmDes Moines

$425

United Airlines

Dec 14

DSM1:15 pmDes Moines

9h 19m

2 stops

BUF11:34 pmBuffalo

Dec 16

BUF10:30 amBuffalo

4h 44m

1 stop

DSM2:14 pmDes Moines

$430

United Airlines

Dec 14

DSM1:15 pmDes Moines

9h 19m

2 stops

BUF11:34 pmBuffalo

Dec 16

BUF11:23 amBuffalo

8h 56m

2 stops

DSM7:19 pmDes Moines

$435

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

Delta

Dec 9

DSM6:09 amDes Moines

4h 15m

1 stop

BUF11:24 amBuffalo

Dec 16

BUF6:10 amBuffalo

4h 40m

1 stop

DSM9:50 amDes Moines

$325

Delta

Dec 9

DSM6:09 amDes Moines

4h 15m

1 stop

BUF11:24 amBuffalo

Dec 16

BUF6:10 amBuffalo

4h 40m

1 stop

DSM9:50 amDes Moines

$347

Delta

Nov 25

DSM6:13 amDes Moines

4h 21m

1 stop

BUF11:34 amBuffalo

Nov 29

BUF12:00 pmBuffalo

5h 49m

1 stop

DSM4:49 pmDes Moines

$607

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

6:09 am-11:24 am

1 stop4h 15m

Buffalo

Wed 12/16

6:10 am-9:50 am

1 stop4h 40m

$325

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

5:24 am-11:42 am

1 stop5h 18m

Buffalo

Wed 12/16

4:21 pm-12:33 am

2 stops9h 12m

$330

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

9:23 am-6:00 pm

2 stops7h 37m

Buffalo

Wed 12/16

4:21 pm-12:33 am

2 stops9h 12m

$335

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

6:09 am-11:24 am

1 stop4h 15m

Buffalo

Wed 12/16

6:10 am-9:50 am

1 stop4h 40m

$347

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

5:24 am-11:42 am

1 stop5h 18m

Buffalo

Wed 12/16

4:21 pm-12:33 am

2 stops9h 12m

$352

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Wed 12/9

2:05 pm-11:11 pm

2 stops8h 06m

Buffalo

Wed 12/16

5:26 am-1:35 pm

2 stops9h 09m

$357

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Mon 12/14

1:23 pm-10:57 pm

1 stop8h 34m

Buffalo

Wed 12/16

6:30 am-12:39 pm

1 stop7h 09m

$425

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Mon 12/14

1:15 pm-11:34 pm

2 stops9h 19m

Buffalo

Wed 12/16

10:30 am-2:14 pm

1 stop4h 44m

$430

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Mon 12/14

1:15 pm-11:34 pm

2 stops9h 19m

Buffalo

Wed 12/16

11:23 am-7:19 pm

2 stops8h 56m

$435

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Mon 12/14

1:23 pm-10:57 pm

1 stop8h 34m

Buffalo

Wed 12/16

1:53 pm-5:14 pm

1 stop4h 21m

$462

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Des Moines during January instead. Flights to Buffalo in January, while not as cheap as those in November, still average around $0.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Best Price Found	$174
Fastest flight time	4h 15m
Direct flights	None

The best one-way flight to Buffalo from Des Moines in the past 72 hours is $174. The best round-trip flight deal from Des Moines to Buffalo found on momondo in the last 72 hours is $325.

The fastest flight from Des Moines to Buffalo takes 4h 15m

There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.

Search flight deals

Frequently asked questions about flying from Des Moines to Buffalo

How far is Des Moines to Buffalo by plane?
The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 4h 15m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?
Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?
As of November 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Buffalo Airport.
How old do you have to be to fly from Des Moines Airport to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Buffalo is American Airlines, representing 100% of all bookings.

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $284	Free Cancellation	Rating 7.0 12,228 reviews		Search American Airlines flights

Batavia

Cheektowaga

Amherst

Williamsville

Tonawanda

Bowmansville

Lockport

Orchard Park

West Seneca

Grand Island

East Aurora

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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Cheap flights from Des Moines to Buffalo from $174

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 12/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Des Moines to Buffalo

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How to get the cheapest flight ticket from Des Moines to Buffalo

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When to book flights from Des Moines to Buffalo

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

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Frequently asked questions about flying from Des Moines to Buffalo

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

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Why use momondo?

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

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Airlines are sorted and displayed according to clicks in the past 7 days on momondo

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List of cabin classes available on flights landing in Buffalo. Availability may vary depending on flight origin and airline.

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