What is the cheapest airline that flies from Des Moines to Buffalo?

United Airlines, Southwest, and American Airlines are the most popular carriers operating from Des Moines to Buffalo

What airlines fly to Buffalo?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Buffalo from Des Moines according to our data. American Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 3 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

As of May 2026, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$111 Cheap Flights from Des Moines to Buffalo in 2026

Q: What is the typical price of a round-trip flight between Des Moines and Buffalo?

Prices are currently low for flights on this route. Typical prices usually range from $596 to $480. The lowest price recently found on this route was $361.

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Find the cheapest flights from Des Moines to Buffalo

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:12 pm - 11:33 am

DSM

BUF

41h 21m

2 stops

8:57 pm - 9:26 pm

BUF

DSM

25h 29m

1 stop

$361Multiple Airlines

Thu, Aug 13 - Sun, Aug 23

6:33 pm - 12:02 am

DSM

BUF

4h 29m

1 stop

6:00 am - 12:56 pm

BUF

DSM

7h 56m

1 stop

$365American Airlines

Fri, Jul 3 - Wed, Jul 8

6:33 pm - 12:02 am

DSM

BUF

4h 29m

1 stop

6:00 am - 12:56 pm

BUF

DSM

7h 56m

2 stops

$370American Airlines

Fri, Jul 3 - Wed, Jul 8

7:09 pm - 12:38 am

DSM

BUF

4h 29m

1 stop

6:26 am - 12:52 pm

BUF

DSM

7h 26m

1 stop

$372American Airlines

Thu, Jun 11 - Wed, Jun 17

5:30 am - 10:20 am

DSM

BUF

3h 50m

1 stop

8:00 pm - 11:05 pm

BUF

DSM

4h 05m

1 stop

$375Southwest

Wed, May 27 - Fri, May 29

7:09 pm - 12:38 am

DSM

BUF

4h 29m

1 stop

6:02 am - 12:52 pm

BUF

DSM

7h 50m

2 stops

$377American Airlines

Thu, Jun 11 - Wed, Jun 17

6:33 am - 12:19 pm

DSM

BUF

4h 46m

1 stop

6:02 am - 12:52 pm

BUF

DSM

7h 50m

2 stops

$380American Airlines

Wed, May 27 - Fri, May 29

7:09 pm - 12:38 am

DSM

BUF

4h 29m

1 stop

1:56 pm - 8:43 pm

BUF

DSM

7h 47m

1 stop

$381American Airlines

Wed, Jun 10 - Thu, Jun 11

6:10 am - 2:20 pm

DSM

BUF

7h 10m

2 stops

10:50 am - 8:45 pm

BUF

DSM

10h 55m

2 stops

$384Southwest

Wed, Sep 16 - Sat, Sep 19

2:40 pm - 8:35 pm

DSM

BUF

4h 55m

1 stop

5:40 am - 1:45 pm

BUF

DSM

9h 05m

2 stops

$386Southwest

Wed, Sep 16 - Fri, Sep 18

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets

Southwest

May 27

DSM5:30 amDes Moines

3h 50m

1 stop

BUF10:20 amBuffalo

May 29

BUF8:00 pmBuffalo

4h 05m

1 stop

DSM11:05 pmDes Moines

$375

Southwest

Sep 16

DSM6:10 amDes Moines

7h 10m

2 stops

BUF2:20 pmBuffalo

Sep 19

BUF10:50 amBuffalo

10h 55m

2 stops

DSM8:45 pmDes Moines

$384

Southwest

Sep 16

DSM2:40 pmDes Moines

4h 55m

1 stop

BUF8:35 pmBuffalo

Sep 18

BUF5:40 amBuffalo

9h 05m

2 stops

DSM1:45 pmDes Moines

$386

American Airlines flights from Des Moines to Buffalo

Our best American Airlines deals on Des Moines to Buffalo flight tickets

American Airlines

Jul 3

DSM6:33 pmDes Moines

4h 29m

1 stop

BUF12:02 amBuffalo

Jul 8

BUF6:00 amBuffalo

7h 56m

1 stop

DSM12:56 pmDes Moines

$365

American Airlines

Jul 3

DSM6:33 pmDes Moines

4h 29m

1 stop

BUF12:02 amBuffalo

Jul 8

BUF6:00 amBuffalo

7h 56m

2 stops

DSM12:56 pmDes Moines

$370

American Airlines

Jun 11

DSM7:09 pmDes Moines

4h 29m

1 stop

BUF12:38 amBuffalo

Jun 17

BUF6:26 amBuffalo

7h 26m

1 stop

DSM12:52 pmDes Moines

$372

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 8/13

5:12 pm-11:33 am

2 stops41h 21m

Buffalo

Sun 8/23

8:57 pm-9:26 pm

1 stop25h 29m

$361

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/3

6:33 pm-12:02 am

1 stop4h 29m

Buffalo

Wed 7/8

6:00 am-12:56 pm

1 stop7h 56m

$365

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 7/3

6:33 pm-12:02 am

1 stop4h 29m

Buffalo

Wed 7/8

6:00 am-12:56 pm

2 stops7h 56m

$370

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/11

7:09 pm-12:38 am

1 stop4h 29m

Buffalo

Wed 6/17

6:26 am-12:52 pm

1 stop7h 26m

$372

Quickest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 5/27

5:30 am-10:20 am

1 stop3h 50m

Buffalo

Fri 5/29

8:00 pm-11:05 pm

1 stop4h 05m

$375

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 6/11

7:09 pm-12:38 am

1 stop4h 29m

Buffalo

Wed 6/17

6:02 am-12:52 pm

2 stops7h 50m

$377

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 5/27

6:33 am-12:19 pm

1 stop4h 46m

Buffalo

Fri 5/29

6:02 am-12:52 pm

2 stops7h 50m

$380

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 6/10

7:09 pm-12:38 am

1 stop4h 29m

Buffalo

Thu 6/11

1:56 pm-8:43 pm

1 stop7h 47m

$381

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 9/16

6:10 am-2:20 pm

2 stops7h 10m

Buffalo

Sat 9/19

10:50 am-8:45 pm

2 stops10h 55m

$384

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 9/16

2:40 pm-8:35 pm

1 stop4h 55m

Buffalo

Fri 9/18

5:40 am-1:45 pm

2 stops9h 05m

$386

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the typical price of a round-trip flight between Des Moines and Buffalo?

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of June, then book flights to Buffalo from Des Moines during October instead. Flights to Buffalo in October, while not as cheap as those in June, still average around $244.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Fastest flight time	3h 55m
Direct flights	None

The fastest flight from Des Moines to Buffalo takes 3h 55m

There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.

Search flight deals

Frequently asked questions about flying from Des Moines to Buffalo

How far is Des Moines to Buffalo by plane?
The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 3h 55m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?
Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?
As of May 2026, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.
How old do you have to be to fly from Des Moines Airport to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Buffalo is American Airlines, representing 40% of all bookings. The subsequent popular airlines are Delta at 37% and United Airlines at 23%.

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $148	Free Cancellation	Rating 7.9 8,454 reviews	Search Delta flights
American Airlines	PriceFrom $238	Free Cancellation	Rating 7.1 11,664 reviews	Search American Airlines flights
United Airlines	PriceFrom $341	Free Cancellation	Rating 7.4 9,711 reviews	Search United Airlines flights

Batavia

Cheektowaga

Amherst

Tonawanda

Grand Island

Williamsville

Orchard Park

Bowmansville

West Seneca

Lockport

East Aurora

Eden

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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Cheap flights from Des Moines to Buffalo from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 7/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Southwest flights from Des Moines to Buffalo

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Our best American Airlines deals on Des Moines to Buffalo flight tickets

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How to get the cheapest flight ticket from Des Moines to Buffalo

What is the typical price of a round-trip flight between Des Moines and Buffalo?

What is the cheapest month to fly to Buffalo?

What is the cheapest airline that flies from Des Moines to Buffalo?

What airlines fly to Buffalo?

When to book flights from Des Moines to Buffalo

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Fastest flight time

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Frequently asked questions about flying from Des Moines to Buffalo

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

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Why use momondo?

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

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List of cabin classes available on flights landing in Buffalo. Availability may vary depending on flight origin and airline.

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