Which layover airport has the shortest connection time from Des Moines to Buffalo?

Chicago (ORD) has the shortest average layover time for this route: 1h 07m.

What is the cheapest airline that flies from Des Moines to Buffalo?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Des Moines to Buffalo

What airlines fly to Buffalo?

Delta, United Airlines and American Airlines are the top three most popular airlines that fly to Buffalo from Des Moines according to our data. Delta is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 3 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between Des Moines and Buffalo?

Chicago (ORD) was the most common stop: 75% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from Des Moines to Buffalo?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 23m.

Which layover airport offers the lowest fares from Des Moines to Buffalo?

Flights via Detroit (DTW) offer the lowest average round-trip price of $331.

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

As of November 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$169 Cheap Flights from Des Moines to Buffalo in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Des Moines to Buffalo

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

3:17 pm - 11:02 pmDSM-BUF

6h 45m1 stop

12:01 pm - 5:48 pmBUF-DSM

6h 47m1 stop

$352Delta

Find Deal

Wed, Dec 10 - Sat, Dec 20

5:45 am - 4:53 pmDSM-BUF

10h 08m2 stops

5:35 pm - 9:40 pmBUF-DSM

5h 05m1 stop

$357United Airlines

Find Deal

Sat, Dec 13 - Sat, Dec 20

8:02 am - 1:17 pmDSM-BUF

4h 15m1 stop

7:00 am - 12:14 pmBUF-DSM

6h 14m1 stop

$360United Airlines

Find Deal

Mon, Nov 24 - Fri, Nov 28

11:26 am - 10:58 pmDSM-BUF

10h 32m2 stops

7:00 am - 10:30 amBUF-DSM

4h 30m1 stop

$365United Airlines

Find Deal

Mon, Nov 24 - Fri, Nov 28

1:17 pm - 10:57 pmDSM-BUF

8h 40m2 stops

6:00 am - 1:21 pmBUF-DSM

8h 21m1 stop

$367American Airlines

Find Deal

Wed, Dec 17 - Mon, Dec 22

11:23 am - 5:18 pmDSM-BUF

4h 55m1 stop

12:01 pm - 5:48 pmBUF-DSM

6h 47m1 stop

$371Delta

Find Deal

Thu, Dec 11 - Sat, Dec 20

5:43 pm - 10:58 pmDSM-BUF

4h 15m1 stop

6:00 am - 10:38 amBUF-DSM

5h 38m1 stop

$387Delta

Find Deal

Fri, Dec 12 - Sun, Dec 21

6:33 am - 11:46 amDSM-BUF

4h 13m1 stop

11:46 am - 9:59 pmBUF-DSM

11h 13m2 stops

$388American Airlines

Find Deal

Tue, Mar 3 - Thu, Mar 5

6:15 am - 3:50 pmDSM-BUF

8h 35m2 stops

3:10 pm - 12:05 amBUF-DSM

9h 55m2 stops

$409Southwest

Find Deal

Wed, Dec 17 - Mon, Dec 22

6:25 am - 4:20 pmDSM-BUF

8h 55m2 stops

5:50 am - 10:55 amBUF-DSM

6h 05m2 stops

$425Southwest

Find Deal

Sat, Dec 13 - Sat, Dec 20

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

Delta

Dec 10

DSM3:17 pmDes Moines

6h 45m

1 stop

BUF11:02 pmBuffalo

Dec 20

BUF12:01 pmBuffalo

6h 47m

1 stop

DSM5:48 pmDes Moines

$352

Find similar

Delta

Dec 11

DSM11:23 amDes Moines

4h 55m

1 stop

BUF5:18 pmBuffalo

Dec 20

BUF12:01 pmBuffalo

6h 47m

1 stop

DSM5:48 pmDes Moines

$371

Find similar

Delta

Dec 12

DSM5:43 pmDes Moines

4h 15m

1 stop

BUF10:58 pmBuffalo

Dec 21

BUF6:00 amBuffalo

5h 38m

1 stop

DSM10:38 amDes Moines

$387

Find similar

United Airlines flights from Des Moines to Buffalo

Our best United Airlines deals on Des Moines to Buffalo flight tickets

United Airlines

Dec 13

DSM5:45 amDes Moines

10h 08m

2 stops

BUF4:53 pmBuffalo

Dec 20

BUF5:35 pmBuffalo

5h 05m

1 stop

DSM9:40 pmDes Moines

$357

Find similar

United Airlines

Nov 24

DSM8:02 amDes Moines

4h 15m

1 stop

BUF1:17 pmBuffalo

Nov 28

BUF7:00 amBuffalo

6h 14m

1 stop

DSM12:14 pmDes Moines

$360

Find similar

United Airlines

Nov 24

DSM11:26 amDes Moines

10h 32m

2 stops

BUF10:58 pmBuffalo

Nov 28

BUF7:00 amBuffalo

4h 30m

1 stop

DSM10:30 amDes Moines

$365

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 12/10

3:17 pm-11:02 pm

1 stop6h 45m

Buffalo

Sat 12/20

12:01 pm-5:48 pm

1 stop6h 47m

$352

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 12/13

5:45 am-4:53 pm

2 stops10h 08m

Buffalo

Sat 12/20

5:35 pm-9:40 pm

1 stop5h 05m

$357

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 11/24

8:02 am-1:17 pm

1 stop4h 15m

Buffalo

Fri 11/28

7:00 am-12:14 pm

1 stop6h 14m

$360

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 11/24

11:26 am-10:58 pm

2 stops10h 32m

Buffalo

Fri 11/28

7:00 am-10:30 am

1 stop4h 30m

$365

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 12/17

1:17 pm-10:57 pm

2 stops8h 40m

Buffalo

Mon 12/22

6:00 am-1:21 pm

1 stop8h 21m

$367

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/11

11:23 am-5:18 pm

1 stop4h 55m

Buffalo

Sat 12/20

12:01 pm-5:48 pm

1 stop6h 47m

$371

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/12

5:43 pm-10:58 pm

1 stop4h 15m

Buffalo

Sun 12/21

6:00 am-10:38 am

1 stop5h 38m

$387

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 3/3

6:33 am-11:46 am

1 stop4h 13m

Buffalo

Thu 3/5

11:46 am-9:59 pm

2 stops11h 13m

$388

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 12/17

6:15 am-3:50 pm

2 stops8h 35m

Buffalo

Mon 12/22

3:10 pm-12:05 am

2 stops9h 55m

$409

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 12/13

6:25 am-4:20 pm

2 stops8h 55m

Buffalo

Sat 12/20

5:50 am-10:55 am

2 stops6h 05m

$425

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $321. Flights from Des Moines to Buffalo on a Friday will generally be more expensive and average around $497. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the morning is the cheapest time of day to fly from Des Moines to Buffalo when you can find flight prices for as low as $356. Flying to Buffalo in the morning is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $452 per ticket.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Direct flights	None

There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.

Search flight deals

How far is Des Moines to Buffalo by plane?
The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 4h 05m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?
Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?
As of November 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.
How old do you have to be to fly from Des Moines Airport to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Buffalo is Delta, representing 40% of all bookings. The subsequent popular airlines are American Airlines at 35% and United Airlines at 26%.

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $148	Free Cancellation	Rating 7.9 8,003 reviews	Search Delta flights
American Airlines	PriceFrom $238	Free Cancellation	Rating 7.2 11,040 reviews	Search American Airlines flights
United Airlines	PriceFrom $360	Free Cancellation	Rating 7.4 9,002 reviews	Search United Airlines flights

Batavia

Cheektowaga

Amherst

Tonawanda

Grand Island

Williamsville

Lockport

Orchard Park

West Seneca

East Aurora

Bowmansville

Eden

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Thu 12/4

Thu 12/11

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Airports servicing New York

Popular cities in the United States

Flights to New Yorkfrom $49

Flights to Los Angelesfrom $49

Flights to Miamifrom $49

Flights to Chicagofrom $54

Flights to Orlandofrom $47

Flights to Las Vegasfrom $49

Flights to San Franciscofrom $54

Flights to Washington, D.C.from $54

Flights to Bostonfrom $40

Flights to Atlantafrom $40

Flights to Dallasfrom $49

Flights to Seattlefrom $68

Cheap flights from Des Moines to Buffalo from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Des Moines to Buffalo

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

United Airlines flights from Des Moines to Buffalo

Our best United Airlines deals on Des Moines to Buffalo flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

See travel insights to Buffalo from

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Buffalo?

What is the cheapest time of day to depart on your flight to Buffalo?

What is the cheapest airline that flies from Des Moines to Buffalo?

American Airlines, Delta, and United Airlines are the most popular carriers operating from Des Moines to Buffalo

What airlines fly to Buffalo?

Which airport is the most popular layover for flights between Des Moines and Buffalo?

Chicago (ORD) was the most common stop: 75% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Des Moines to Buffalo?

Flights via Detroit (DTW) offer the lowest average round-trip price of $331.

Which layover airport has the shortest travel time from Des Moines to Buffalo?

Flights connecting via Chicago (ORD) have the shortest average one-way travel time: 4h 23m.

Which layover airport has the shortest connection time from Des Moines to Buffalo?

Chicago (ORD) has the shortest average layover time for this route: 1h 07m.

When to book flights from Des Moines to Buffalo

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Direct flights

How far is Des Moines to Buffalo by plane?

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

What documentation or ID do you need to fly to Buffalo Airport?

What is the most popular airline from Des Moines to Buffalo?

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Traveling to a place near Buffalo?

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

How can momondo help me find flights from Des Moines to Buffalo?

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing New York