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Cheap flights from Des Moines to Buffalo from $168

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:16 pm - 9:36 pm
DSM
-
BUF
6h 20m
1 stop
American Airlines Logo
11:31 am - 4:31 pm
BUF
-
DSM
6h 00m
1 stop
$335American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
12:00 pm - 9:20 pm
DSM
-
BUF
8h 20m
2 stops
American Airlines Logo
6:00 am - 11:30 am
BUF
-
DSM
6h 30m
1 stop
$356American Airlines
Tue, Apr 7 - Tue, Apr 14
American Airlines Logo
12:00 pm - 5:30 pm
DSM
-
BUF
4h 30m
1 stop
American Airlines Logo
5:42 pm - 9:54 pm
BUF
-
DSM
5h 12m
1 stop
$358American Airlines
Sat, May 2 - Sat, May 9
Southwest Logo
5:35 am - 2:15 pm
DSM
-
BUF
7h 40m
2 stops
Southwest Logo
3:25 pm - 8:55 pm
BUF
-
DSM
6h 30m
1 stop
$362Southwest
Sat, May 2 - Sat, May 9
Southwest Logo
5:25 am - 10:15 am
DSM
-
BUF
3h 50m
1 stop
Southwest Logo
3:25 pm - 8:55 pm
BUF
-
DSM
6h 30m
1 stop
$366Southwest
Thu, Apr 16 - Sat, Apr 18
Southwest Logo
5:25 am - 10:15 am
DSM
-
BUF
3h 50m
1 stop
Southwest Logo
3:10 pm - 10:10 pm
BUF
-
DSM
8h 00m
1 stop
$370Southwest
Thu, Apr 9 - Wed, Apr 15
American Airlines Logo
6:02 am - 2:19 pm
DSM
-
BUF
7h 17m
1 stop
American Airlines Logo
7:34 pm - 12:06 am
BUF
-
DSM
5h 32m
1 stop
$375American Airlines
Wed, Jul 8 - Wed, Jul 22
United Airlines Logo
8:04 am - 1:13 pm
DSM
-
BUF
4h 09m
1 stop
United Airlines Logo
7:00 am - 4:15 pm
BUF
-
DSM
10h 15m
2 stops
$379United Airlines
Thu, Apr 16 - Sat, Apr 18
United Airlines Logo
5:00 am - 2:25 pm
DSM
-
BUF
8h 25m
2 stops
United Airlines Logo
7:00 am - 10:27 am
BUF
-
DSM
4h 27m
1 stop
$380United Airlines
Wed, Jul 8 - Wed, Jul 22
American Airlines Logo
8:52 am - 5:41 pm
DSM
-
BUF
7h 49m
2 stops
American Airlines Logo
6:00 am - 12:56 pm
BUF
-
DSM
7h 56m
2 stops
$386American Airlines
Wed, Jul 8 - Wed, Jul 22

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets
Southwest
May 2
DSM5:35 amDes Moines
7h 40m
2 stops
BUF2:15 pmBuffalo
May 9
BUF3:25 pmBuffalo
6h 30m
1 stop
DSM8:55 pmDes Moines
$362
Southwest
Apr 16
DSM5:25 amDes Moines
3h 50m
1 stop
BUF10:15 amBuffalo
Apr 18
BUF3:25 pmBuffalo
6h 30m
1 stop
DSM8:55 pmDes Moines
$366
Southwest
Apr 9
DSM5:25 amDes Moines
3h 50m
1 stop
BUF10:15 amBuffalo
Apr 15
BUF3:10 pmBuffalo
8h 00m
1 stop
DSM10:10 pmDes Moines
$370

American Airlines flights from Des Moines to Buffalo

Our best American Airlines deals on Des Moines to Buffalo flight tickets
American Airlines
Apr 7
DSM2:16 pmDes Moines
6h 20m
1 stop
BUF9:36 pmBuffalo
Apr 14
BUF11:31 amBuffalo
6h 00m
1 stop
DSM4:31 pmDes Moines
$335
American Airlines
Apr 7
DSM12:00 pmDes Moines
8h 20m
2 stops
BUF9:20 pmBuffalo
Apr 14
BUF6:00 amBuffalo
6h 30m
1 stop
DSM11:30 amDes Moines
$356
American Airlines
May 2
DSM12:00 pmDes Moines
4h 30m
1 stop
BUF5:30 pmBuffalo
May 9
BUF5:42 pmBuffalo
5h 12m
1 stop
DSM9:54 pmDes Moines
$358

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 4/7

2:16 pm-9:36 pm

1 stop6h 20m

Buffalo

Tue 4/14

11:31 am-4:31 pm

1 stop6h 00m

$335

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 4/7

12:00 pm-9:20 pm

2 stops8h 20m

Buffalo

Tue 4/14

6:00 am-11:30 am

1 stop6h 30m

$356
Quickest round-trip

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 5/2

12:00 pm-5:30 pm

1 stop4h 30m

Buffalo

Sat 5/9

5:42 pm-9:54 pm

1 stop5h 12m

$358

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sat 5/2

5:35 am-2:15 pm

2 stops7h 40m

Buffalo

Sat 5/9

3:25 pm-8:55 pm

1 stop6h 30m

$362

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 4/16

5:25 am-10:15 am

1 stop3h 50m

Buffalo

Sat 4/18

3:25 pm-8:55 pm

1 stop6h 30m

$366

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 4/9

5:25 am-10:15 am

1 stop3h 50m

Buffalo

Wed 4/15

3:10 pm-10:10 pm

1 stop8h 00m

$370

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 7/8

6:02 am-2:19 pm

1 stop7h 17m

Buffalo

Wed 7/22

7:34 pm-12:06 am

1 stop5h 32m

$375

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 4/16

8:04 am-1:13 pm

1 stop4h 09m

Buffalo

Sat 4/18

7:00 am-4:15 pm

2 stops10h 15m

$379

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 7/8

5:00 am-2:25 pm

2 stops8h 25m

Buffalo

Wed 7/22

7:00 am-10:27 am

1 stop4h 27m

$380

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Wed 7/8

8:52 am-5:41 pm

2 stops7h 49m

Buffalo

Wed 7/22

6:00 am-12:56 pm

2 stops7h 56m

$386

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of October, then book flights to Buffalo from Des Moines during September instead. Flights to Buffalo in September, while not as cheap as those in October, still average around $300.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Des Moines to Buffalo takes 3h 50m
There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.
Search flight deals

  • How far is Des Moines to Buffalo by plane?

    The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 3h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

    Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

  • How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Buffalo?

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
8,312 reviews
Search Delta flights
American AirlinesPriceFrom $238Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights
United AirlinesPriceFrom $341Free CancellationRating
7.4
9,452 reviews
Search United Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Orchard Park
Williamsville
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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