What is the cheapest airline that flies from Des Moines to Buffalo?

United Airlines, Southwest, and American Airlines are the most popular carriers operating from Des Moines to Buffalo

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

As of September 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Buffalo Airport.

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$163 Cheap Flights from Des Moines to Buffalo in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Buffalo

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:20 am - 10:25 amDSM Des Moines-BUF Buffalo

4h 05m1 stop Chicago Midway

4:35 pm - 7:45 pmBUF Buffalo-DSM Des Moines

4h 10m1 stop Chicago Midway

$325Southwest

Sat, Nov 7 - Sat, Nov 14

5:20 am - 2:55 pmDSM Des Moines-BUF Buffalo

8h 35m2 stops Chicago Midway Baltimore/Washington

4:35 pm - 7:45 pmBUF Buffalo-DSM Des Moines

4h 10m1 stop Chicago Midway

$330Southwest

Sat, Nov 7 - Sat, Nov 14

5:20 am - 2:55 pmDSM Des Moines-BUF Buffalo

8h 35m2 stops Chicago Midway Baltimore/Washington

1:10 pm - 7:45 pmBUF Buffalo-DSM Des Moines

7h 35m2 stops Baltimore/Washington Chicago Midway

$335Southwest

Sat, Nov 7 - Sat, Nov 14

5:25 am - 10:25 amDSM Des Moines-BUF Buffalo

4h 00m1 stop Chicago Midway

4:55 pm - 10:05 pmBUF Buffalo-DSM Des Moines

6h 10m1 stop Denver Intl

$350Southwest

Fri, Nov 6 - Mon, Nov 9

1:58 pm - 9:37 pmDSM Des Moines-BUF Buffalo

6h 39m1 stop Chicago O'Hare Intl

4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines

9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl

$376American Airlines

Fri, Nov 6 - Mon, Nov 9

1:58 pm - 10:33 pmDSM Des Moines-BUF Buffalo

7h 35m2 stops Chicago O'Hare Intl New York LaGuardia

4:16 pm - 12:26 amBUF Buffalo-DSM Des Moines

9h 10m2 stops Boston Logan Intl Chicago O'Hare Intl

$381American Airlines

Fri, Nov 6 - Mon, Nov 9

5:50 pm - 11:59 pmDSM Des Moines-BUF Buffalo

5h 09m1 stop Detroit Metropolitan Wayne County

6:15 am - 9:42 amBUF Buffalo-DSM Des Moines

4h 27m1 stop Detroit Metropolitan Wayne County

$381Delta

Sun, Oct 25 - Tue, Oct 27

6:02 am - 2:25 pmDSM Des Moines-BUF Buffalo

7h 23m1 stop Washington, D.C. Reagan-National

8:00 am - 12:45 pmBUF Buffalo-DSM Des Moines

5h 45m1 stop Philadelphia

$381American Airlines

Sun, Oct 25 - Tue, Oct 27

6:02 am - 2:25 pmDSM Des Moines-BUF Buffalo

7h 23m1 stop Washington, D.C. Reagan-National

5:40 pm - 12:14 amBUF Buffalo-DSM Des Moines

7h 34m2 stops New York LaGuardia Chicago O'Hare Intl

$386American Airlines

Sun, Oct 25 - Tue, Oct 27

5:10 am - 1:00 pmDSM Des Moines-BUF Buffalo

6h 50m2 stops Chicago Midway Baltimore/Washington

7:00 pm - 10:00 pmBUF Buffalo-DSM Des Moines

4h 00m1 stop Chicago Midway

$386Southwest

Thu, Oct 15 - Tue, Oct 20

Cheap last minute flights

Enter your travel dates to find the best prices.

2:44 pm - 10:10 pmDSM Des Moines-BUF Buffalo

6h 26m1 stop Chicago O'Hare Intl

7:53 pm - 11:58 pmBUF Buffalo-DSM Des Moines

5h 05m1 stop Charlotte Douglas

$662American Airlines

Sat, Oct 3 - Sat, Oct 10

6:00 am - 3:24 pmDSM Des Moines-BUF Buffalo

8h 24m2 stops Philadelphia Boston Logan Intl

7:53 pm - 11:58 pmBUF Buffalo-DSM Des Moines

5h 05m1 stop Charlotte Douglas

$667American Airlines

Sat, Oct 3 - Sat, Oct 10

5:50 am - 5:35 pmDSM Des Moines-BUF Buffalo

10h 45m2 stops Chicago Midway Baltimore/Washington

10:30 am - 8:50 pmBUF Buffalo-DSM Des Moines

11h 20m2 stops Orlando Chicago Midway

$692Southwest

Sat, Oct 3 - Sat, Oct 10

2:29 pm - 10:10 pmDSM Des Moines-BUF Buffalo

6h 41m1 stop Chicago O'Hare Intl

5:17 pm - 10:43 pmBUF Buffalo-DSM Des Moines

6h 26m1 stop Philadelphia

$912American Airlines

Fri, Oct 2 - Mon, Oct 5

9:15 am - 8:47 pmDSM Des Moines-BUF Buffalo

10h 32m2 stops Denver Intl Chicago O'Hare Intl

7:00 am - 10:31 amBUF Buffalo-DSM Des Moines

4h 31m1 stop Chicago O'Hare Intl

$917United Airlines

Fri, Oct 2 - Mon, Oct 5

5:10 am - 12:00 pmDSM Des Moines-BUF Buffalo

5h 50m2 stops Chicago Midway Baltimore/Washington

2:50 pm - 10:10 pmBUF Buffalo-DSM Des Moines

8h 20m2 stops Baltimore/Washington Denver Intl

$952Southwest

Fri, Oct 2 - Mon, Oct 5

2:13 pm - 12:07 amDSM Des Moines-BUF Buffalo

8h 54m1 stop Washington, D.C. Reagan-National

10:43 am - 9:36 pmBUF Buffalo-DSM Des Moines

11h 53m1 stop Philadelphia

$970American Airlines

Thu, Oct 1 - Sat, Oct 3

2:44 pm - 10:10 pmDSM Des Moines-BUF Buffalo

6h 26m1 stop Chicago O'Hare Intl

6:30 am - 12:04 pmBUF Buffalo-DSM Des Moines

6h 34m1 stop Charlotte Douglas

$1,017American Airlines

Tue, Sep 29 - Thu, Oct 1

8:00 am - 1:11 pmDSM Des Moines-BUF Buffalo

4h 11m1 stop Chicago O'Hare Intl

3:05 pm - 11:35 pmBUF Buffalo-DSM Des Moines

9h 30m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$1,022United Airlines

Tue, Sep 29 - Thu, Oct 1

5:45 am - 4:43 pmDSM Des Moines-BUF Buffalo

9h 58m2 stops Denver Intl Chicago O'Hare Intl

7:00 am - 10:31 amBUF Buffalo-DSM Des Moines

4h 31m1 stop Chicago O'Hare Intl

$1,022United Airlines

Thu, Oct 1 - Sat, Oct 3

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets

Southwest

Nov 6

DSM5:25 amDes Moines

4h 00m

1 stop

BUF10:25 amBuffalo

Nov 9

BUF4:55 pmBuffalo

6h 10m

1 stop

DSM10:05 pmDes Moines

$350

Southwest

Oct 15

DSM5:10 amDes Moines

6h 50m

2 stops

BUF1:00 pmBuffalo

Oct 20

BUF7:00 pmBuffalo

4h 00m

1 stop

DSM10:00 pmDes Moines

$386

Southwest

Nov 20

DSM5:25 amDes Moines

4h 00m

1 stop

BUF10:25 amBuffalo

Nov 22

BUF9:15 amBuffalo

10h 20m

1 stop

DSM6:35 pmDes Moines

$417

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

Delta

Oct 25

DSM5:50 pmDes Moines

5h 09m

1 stop

BUF11:59 pmBuffalo

Oct 27

BUF6:15 amBuffalo

4h 27m

1 stop

DSM9:42 amDes Moines

$381

Delta

Dec 29

DSM6:15 amDes Moines

4h 12m

1 stop

BUF11:27 amBuffalo

Jan 4

BUF5:55 pmBuffalo

3h 57m

1 stop

DSM8:52 pmDes Moines

$396

Delta

Oct 16

DSM5:50 pmDes Moines

5h 09m

1 stop

BUF11:59 pmBuffalo

Oct 25

BUF6:15 amBuffalo

4h 27m

1 stop

DSM9:42 amDes Moines

$406

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 11/7

5:20 am-10:25 am

1 stop4h 05m

Buffalo

Sat 11/14

4:35 pm-7:45 pm

1 stop4h 10m

$325

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 11/7

5:20 am-2:55 pm

2 stops8h 35m

Buffalo

Sat 11/14

4:35 pm-7:45 pm

1 stop4h 10m

$330

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 11/7

5:20 am-2:55 pm

2 stops8h 35m

Buffalo

Sat 11/14

1:10 pm-7:45 pm

2 stops7h 35m

$335

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Fri 11/6

5:25 am-10:25 am

1 stop4h 00m

Buffalo

Mon 11/9

4:55 pm-10:05 pm

1 stop6h 10m

$350

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Fri 11/6

1:58 pm-9:37 pm

1 stop6h 39m

Buffalo

Mon 11/9

4:16 pm-12:26 am

2 stops9h 10m

$376

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Fri 11/6

1:58 pm-10:33 pm

2 stops7h 35m

Buffalo

Mon 11/9

4:16 pm-12:26 am

2 stops9h 10m

$381

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sun 10/25

5:50 pm-11:59 pm

1 stop5h 09m

Buffalo

Tue 10/27

6:15 am-9:42 am

1 stop4h 27m

$381

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sun 10/25

6:02 am-2:25 pm

1 stop7h 23m

Buffalo

Tue 10/27

8:00 am-12:45 pm

1 stop5h 45m

$381

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sun 10/25

6:02 am-2:25 pm

1 stop7h 23m

Buffalo

Tue 10/27

5:40 pm-12:14 am

2 stops7h 34m

$386

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Thu 10/15

5:10 am-1:00 pm

2 stops6h 50m

Buffalo

Tue 10/20

7:00 pm-10:00 pm

1 stop4h 00m

$386

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Des Moines during October instead. Flights to Buffalo in October, while not as cheap as those in November, still average around $250.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Best Price Found	$163
Fastest flight time	4h 05m
Direct flights	None

The best one-way flight to Buffalo from Des Moines in the past 72 hours is $163. The best round-trip flight deal from Des Moines to Buffalo found on momondo in the last 72 hours is $325.

The fastest flight from Des Moines to Buffalo takes 4h 05m

There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.

Search flight deals

Frequently asked questions about flying from Des Moines to Buffalo

How far is Des Moines to Buffalo by plane?
The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 4h 05m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?
Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?
As of September 2026, there is 1 operator available to choose from for flights from Des Moines Airport to Buffalo Airport.
How old do you have to be to fly from Des Moines Airport to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Buffalo is American Airlines, representing 100% of all bookings.

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $250	Free Cancellation	Rating 7.0 12,099 reviews		Search American Airlines flights

Batavia

Cheektowaga

Amherst

Williamsville

Tonawanda

Bowmansville

Lockport

West Seneca

Orchard Park

Grand Island

East Aurora

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Start using Trips

Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

1 adult

Wed 10/28

Wed 11/4

Email me momondo's favorite deals

By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States

Nearby airports

Airlines

Cabin classes

Other United States destinations

Other flights from Des Moines

Complete your trip

Feeling lucky

Cheap flights from Des Moines to Buffalo from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 10/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Find the cheapest flights from Des Moines to Buffalo

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

See travel insights to Buffalo from

How to get the cheapest flight ticket from Des Moines to Buffalo

What is the cheapest month to fly to Buffalo?

What is the cheapest airline that flies from Des Moines to Buffalo?

When to book flights from Des Moines to Buffalo

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Des Moines to Buffalo

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Traveling to a place near Buffalo?

Why use momondo?

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing New York

Fly your favorite airline to Buffalo

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Buffalo

List of cabin classes available on flights landing in Buffalo. Availability may vary depending on flight origin and airline.

Popular cities in the United States

Popular flights according to clicks in the last 7 days on momondo

Fly to other destinations from Des Moines

According to popular flight searches on momondo this year

Complete your trip to Buffalo

Explore popular destinations other users love

According to popular flight searches on momondo this year