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Cheap flights from Des Moines to Buffalo from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 9/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:35 pm - 10:35 pmDSM  Des Moines-BUF Buffalo
4h 00m1 stop Detroit Metropolitan Wayne County
Delta Logo
6:20 am - 9:38 amBUF  Buffalo-DSM Des Moines
4h 18m1 stop Detroit Metropolitan Wayne County
$269Delta
Sat, Sep 26 - Sat, Oct 3
Delta Logo
5:35 pm - 10:35 pmDSM  Des Moines-BUF Buffalo
4h 00m1 stop Detroit Metropolitan Wayne County
Delta Logo
12:02 pm - 5:19 pmBUF  Buffalo-DSM Des Moines
6h 17m1 stop Detroit Metropolitan Wayne County
$269Delta
Sat, Sep 26 - Wed, Sep 30
American Airlines Logo
6:05 am - 12:46 pmDSM  Des Moines-BUF Buffalo
5h 41m1 stop Philadelphia
American Airlines Logo
5:57 pm - 11:04 pmBUF  Buffalo-DSM Des Moines
6h 07m1 stop Washington, D.C. Reagan-National
$269American Airlines
Sat, Oct 17 - Wed, Oct 21
American Airlines Logo
2:44 pm - 10:10 pmDSM  Des Moines-BUF Buffalo
6h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
6:10 am - 12:31 pmBUF  Buffalo-DSM Des Moines
7h 21m1 stop Philadelphia
$269American Airlines
Sat, Sep 26 - Wed, Sep 30
United Airlines Logo
11:27 am - 4:43 pmDSM  Des Moines-BUF Buffalo
4h 16m1 stop Chicago O'Hare Intl
United Airlines Logo
7:00 am - 10:31 amBUF  Buffalo-DSM Des Moines
4h 31m1 stop Chicago O'Hare Intl
$269United Airlines
Sat, Sep 26 - Thu, Oct 1
United Airlines Logo
1:26 pm - 11:11 pmDSM  Des Moines-BUF Buffalo
8h 45m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
10:46 am - 2:15 pmBUF  Buffalo-DSM Des Moines
4h 29m1 stop Chicago O'Hare Intl
$274United Airlines
Sat, Oct 17 - Wed, Oct 21
American Airlines Logo
2:44 pm - 10:10 pmDSM  Des Moines-BUF Buffalo
6h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
5:18 pm - 12:04 amBUF  Buffalo-DSM Des Moines
7h 46m2 stops Philadelphia Chicago O'Hare Intl
$274American Airlines
Sat, Sep 26 - Wed, Sep 30
Southwest Logo
5:50 am - 5:35 pmDSM  Des Moines-BUF Buffalo
10h 45m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
4:25 pm - 9:55 pmBUF  Buffalo-DSM Des Moines
6h 30m2 stops Baltimore/Washington Chicago Midway
$280Southwest
Sat, Oct 17 - Wed, Oct 21
American Airlines Logo
2:44 pm - 10:10 pmDSM  Des Moines-BUF Buffalo
6h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
5:57 pm - 10:20 pmBUF  Buffalo-DSM Des Moines
5h 23m1 stop Washington, D.C. Reagan-National
$297American Airlines
Sat, Sep 26 - Fri, Oct 30
Southwest Logo
5:40 am - 10:50 amDSM  Des Moines-BUF Buffalo
4h 10m1 stop Chicago Midway
Southwest Logo
7:35 pm - 10:55 pmBUF  Buffalo-DSM Des Moines
4h 20m1 stop Chicago Midway
$343Southwest
Sun, Sep 27 - Fri, Oct 30

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United Airlines flights from Des Moines to Buffalo

Our best United Airlines deals on Des Moines to Buffalo flight tickets
United Airlines
Oct 29
DSM1:27 pmDes Moines
8h 11m
1 stop
BUF10:38 pmBuffalo
Oct 31
BUF5:49 pmBuffalo
6h 01m
1 stop
DSM10:50 pmDes Moines
$349
United Airlines
Sep 25
DSM1:27 pmDes Moines
8h 16m
1 stop
BUF10:43 pmBuffalo
Oct 30
BUF6:30 amBuffalo
4h 56m
1 stop
DSM10:26 amDes Moines
$352
United Airlines
Oct 29
DSM1:27 pmDes Moines
8h 11m
1 stop
BUF10:38 pmBuffalo
Oct 31
BUF5:49 pmBuffalo
6h 01m
1 stop
DSM10:50 pmDes Moines
$386

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets
Southwest
Oct 17
DSM5:50 amDes Moines
10h 45m
2 stops
BUF5:35 pmBuffalo
Oct 21
BUF4:25 pmBuffalo
6h 30m
2 stops
DSM9:55 pmDes Moines
$280
Southwest
Sep 27
DSM5:40 amDes Moines
4h 10m
1 stop
BUF10:50 amBuffalo
Oct 30
BUF7:35 pmBuffalo
4h 20m
1 stop
DSM10:55 pmDes Moines
$343
Southwest
Sep 26
DSM5:30 amDes Moines
9h 10m
2 stops
BUF3:40 pmBuffalo
Oct 3
BUF8:50 amBuffalo
4h 10m
1 stop
DSM12:00 pmDes Moines
$348

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

5:35 pm-10:35 pm

1 stop4h 00m

Buffalo

Sat 10/3

6:20 am-9:38 am

1 stop4h 18m

$269

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

5:35 pm-10:35 pm

1 stop4h 00m

Buffalo

Wed 9/30

12:02 pm-5:19 pm

1 stop6h 17m

$269

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 10/17

6:05 am-12:46 pm

1 stop5h 41m

Buffalo

Wed 10/21

5:57 pm-11:04 pm

1 stop6h 07m

$269

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

2:44 pm-10:10 pm

1 stop6h 26m

Buffalo

Wed 9/30

6:10 am-12:31 pm

1 stop7h 21m

$269

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

11:27 am-4:43 pm

1 stop4h 16m

Buffalo

Thu 10/1

7:00 am-10:31 am

1 stop4h 31m

$269

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 10/17

1:26 pm-11:11 pm

2 stops8h 45m

Buffalo

Wed 10/21

10:46 am-2:15 pm

1 stop4h 29m

$274

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

2:44 pm-10:10 pm

1 stop6h 26m

Buffalo

Wed 9/30

5:18 pm-12:04 am

2 stops7h 46m

$274

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 10/17

5:50 am-5:35 pm

2 stops10h 45m

Buffalo

Wed 10/21

4:25 pm-9:55 pm

2 stops6h 30m

$280

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sat 9/26

2:44 pm-10:10 pm

1 stop6h 26m

Buffalo

Fri 10/30

5:57 pm-10:20 pm

1 stop5h 23m

$297

Des MoinesBuffalo

DSM Des Moines - BUF Buffalo

DSMBUF

Des Moines

Sun 9/27

5:40 am-10:50 am

1 stop4h 10m

Buffalo

Fri 10/30

7:35 pm-10:55 pm

1 stop4h 20m

$343

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of November, then book flights to Buffalo from Des Moines during October instead. Flights to Buffalo in October, while not as cheap as those in November, still average around $250.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Fastest flight time

4h 22m

Direct flights

None
The fastest flight from Des Moines to Buffalo takes 4h 22m
There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.
Search flight deals

Frequently asked questions about flying from Des Moines to Buffalo

  • How far is Des Moines to Buffalo by plane?

    The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 4h 22m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

    Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

  • How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Buffalo?

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.8
8,502 reviews
Search Delta flights
American AirlinesPriceFrom $238Free CancellationRating
7.1
11,929 reviews
Search American Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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