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Cheap flights from Des Moines to Buffalo from $194

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 1/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:01 pm - 11:48 pm
DSM
-
BUF
5h 47m1 stop
American Airlines Logo
6:32 pm - 11:08 pm
BUF
-
DSM
5h 36m1 stop
$311American Airlines
mar., janv. 6 - mar., janv. 13
American Airlines Logo
4:25 pm - 11:41 pm
DSM
-
BUF
6h 16m1 stop
American Airlines Logo
11:27 am - 9:04 pm
BUF
-
DSM
10h 37m2 stops
$316American Airlines
mar., janv. 6 - mar., janv. 13
Delta Logo
10:21 am - 4:59 pm
DSM
-
BUF
5h 38m1 stop
Delta Logo
6:03 am - 9:41 am
BUF
-
DSM
4h 38m1 stop
$341Delta
jeu., janv. 29 - jeu., févr. 5
American Airlines Logo
6:00 am - 3:17 pm
DSM
-
BUF
8h 17m2 stops
American Airlines Logo
5:27 pm - 10:11 pm
BUF
-
DSM
5h 44m1 stop
$347American Airlines
jeu., janv. 29 - jeu., févr. 5
United Airlines Logo
3:35 pm - 8:29 pm
DSM
-
BUF
3h 54m1 stop
United Airlines Logo
5:23 pm - 9:50 pm
BUF
-
DSM
5h 27m1 stop
$351United Airlines
jeu., janv. 15 - jeu., janv. 22
American Airlines Logo
1:16 pm - 10:40 pm
DSM
-
BUF
8h 24m2 stops
American Airlines Logo
6:00 am - 3:44 pm
BUF
-
DSM
10h 44m2 stops
$353American Airlines
jeu., janv. 29 - jeu., févr. 5
American Airlines Logo
11:42 am - 10:40 pm
DSM
-
BUF
9h 58m2 stops
American Airlines Logo
11:27 am - 9:04 pm
BUF
-
DSM
10h 37m2 stops
$355American Airlines
mar., janv. 6 - mar., janv. 13
United Airlines Logo
3:35 pm - 8:29 pm
DSM
-
BUF
3h 54m1 stop
United Airlines Logo
6:00 am - 2:33 pm
BUF
-
DSM
9h 33m2 stops
$356United Airlines
jeu., janv. 15 - jeu., janv. 22
Delta Logo
5:16 pm - 11:28 pm
DSM
-
BUF
5h 12m1 stop
Delta Logo
6:00 am - 10:41 am
BUF
-
DSM
5h 41m1 stop
$387Delta
jeu., janv. 29 - jeu., févr. 5
Southwest Logo
5:20 am - 2:05 pm
DSM
-
BUF
7h 45m2 stops
Southwest Logo
1:20 pm - 9:10 pm
BUF
-
DSM
8h 50m2 stops
$389Southwest
jeu., janv. 15 - jeu., janv. 22

American Airlines flights from Des Moines to Buffalo

Our best American Airlines deals on Des Moines to Buffalo flight tickets
American Airlines
Jan 6
DSM5:01 pmDes Moines
5h 47m
1 stop
BUF11:48 pmBuffalo
Jan 13
BUF6:32 pmBuffalo
5h 36m
1 stop
DSM11:08 pmDes Moines
$311
Find similar
American Airlines
Jan 6
DSM4:25 pmDes Moines
6h 16m
1 stop
BUF11:41 pmBuffalo
Jan 13
BUF11:27 amBuffalo
10h 37m
2 stops
DSM9:04 pmDes Moines
$316
Find similar
American Airlines
Jan 6
DSM11:42 amDes Moines
9h 58m
2 stops
BUF10:40 pmBuffalo
Jan 13
BUF11:27 amBuffalo
10h 37m
2 stops
DSM9:04 pmDes Moines
$355
Find similar

United Airlines flights from Des Moines to Buffalo

Our best United Airlines deals on Des Moines to Buffalo flight tickets
United Airlines
Jan 15
DSM3:35 pmDes Moines
3h 54m
1 stop
BUF8:29 pmBuffalo
Jan 22
BUF5:23 pmBuffalo
5h 27m
1 stop
DSM9:50 pmDes Moines
$351
Find similar
United Airlines
Jan 15
DSM3:35 pmDes Moines
3h 54m
1 stop
BUF8:29 pmBuffalo
Jan 22
BUF6:00 amBuffalo
9h 33m
2 stops
DSM2:33 pmDes Moines
$356
Find similar
United Airlines
Jan 16
DSM3:35 pmDes Moines
3h 54m
1 stop
BUF8:29 pmBuffalo
Jan 23
BUF8:30 amBuffalo
7h 03m
1 stop
DSM2:33 pmDes Moines
$387
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated décembre 18, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mar. 1/6

5:01 pm-11:48 pm

1 stop5h 47m

Buffalo

mar. 1/13

6:32 pm-11:08 pm

1 stop5h 36m

$311

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mar. 1/6

4:25 pm-11:41 pm

1 stop6h 16m

Buffalo

mar. 1/13

11:27 am-9:04 pm

2 stops10h 37m

$316

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/29

10:21 am-4:59 pm

1 stop5h 38m

Buffalo

jeu. 2/5

6:03 am-9:41 am

1 stop4h 38m

$341

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/29

6:00 am-3:17 pm

2 stops8h 17m

Buffalo

jeu. 2/5

5:27 pm-10:11 pm

1 stop5h 44m

$347

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/15

3:35 pm-8:29 pm

1 stop3h 54m

Buffalo

jeu. 1/22

5:23 pm-9:50 pm

1 stop5h 27m

$351

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/29

1:16 pm-10:40 pm

2 stops8h 24m

Buffalo

jeu. 2/5

6:00 am-3:44 pm

2 stops10h 44m

$353

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

mar. 1/6

11:42 am-10:40 pm

2 stops9h 58m

Buffalo

mar. 1/13

11:27 am-9:04 pm

2 stops10h 37m

$355

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/15

3:35 pm-8:29 pm

1 stop3h 54m

Buffalo

jeu. 1/22

6:00 am-2:33 pm

2 stops9h 33m

$356

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/29

5:16 pm-11:28 pm

1 stop5h 12m

Buffalo

jeu. 2/5

6:00 am-10:41 am

1 stop5h 41m

$387

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

jeu. 1/15

5:20 am-2:05 pm

2 stops7h 45m

Buffalo

jeu. 1/22

1:20 pm-9:10 pm

2 stops8h 50m

$389

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $321. Flights from Des Moines to Buffalo on a Friday will generally be more expensive and average around $497. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the morning is the cheapest time of day to fly from Des Moines to Buffalo when you can find flight prices for as low as $356. Flying to Buffalo in the morning is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $452 per ticket.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Des Moines to Buffalo takes 3h 50m
There are no direct flights from Des Moines to Buffalo. There are no popular flight routes from Des Moines to Buffalo.
Search flight deals

  • How far is Des Moines to Buffalo by plane?

    The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 3h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

    Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

  • How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Buffalo?

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $238Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
United AirlinesPriceFrom $360Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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