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Cheap flights from Des Moines to Buffalo from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Buffalo departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Buffalo (DSM-BUF)

Cheap round-trip flights

Delta Logo
6:20 am - 11:43 amDSM-BUF
4h 23m1 stop
Delta Logo
6:00 am - 10:18 amBUF-DSM
5h 18m1 stop
$237Delta
Find Deal
Thu, Dec 4 - Tue, Dec 9
American Airlines Logo
12:44 pm - 6:34 pmDSM-BUF
4h 50m1 stop
American Airlines Logo
6:00 am - 12:39 pmBUF-DSM
7h 39m2 stops
$242American Airlines
Find Deal
Mon, Aug 25 - Wed, Aug 27
American Airlines Logo
8:00 am - 5:55 pmDSM-BUF
8h 55m2 stops
American Airlines Logo
6:45 pm - 11:06 pmBUF-DSM
5h 21m1 stop
$243American Airlines
Find Deal
Tue, Sep 16 - Tue, Sep 23
American Airlines Logo
5:00 am - 11:06 amDSM-BUF
5h 06m1 stop
American Airlines Logo
7:30 am - 1:51 pmBUF-DSM
7h 21m1 stop
$259American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5
American Airlines Logo
6:11 pm - 12:12 amDSM-BUF
5h 01m1 stop
American Airlines Logo
6:49 pm - 11:06 pmBUF-DSM
5h 17m1 stop
$281American Airlines
Find Deal
Sun, Sep 7 - Fri, Sep 12
Delta Logo
5:25 pm - 11:03 pmDSM-BUF
4h 38m1 stop
Delta Logo
10:15 am - 4:02 pmBUF-DSM
6h 47m1 stop
$288Delta
Find Deal
Fri, Dec 5 - Tue, Dec 9
Southwest Logo
8:20 am - 8:40 pmDSM-BUF
11h 20m2 stops
Southwest Logo
10:50 am - 9:00 pmBUF-DSM
11h 10m2 stops
$349Southwest
Find Deal
Fri, Dec 5 - Sun, Dec 7
Southwest Logo
8:20 am - 8:40 pmDSM-BUF
11h 20m2 stops
Southwest Logo
10:40 am - 9:00 pmBUF-DSM
11h 20m1 stop
$350Southwest
Find Deal
Fri, Dec 5 - Sun, Dec 7
United Airlines Logo
6:30 am - 2:12 pmDSM-BUF
6h 42m2 stops
United Airlines Logo
7:07 am - 12:19 pmBUF-DSM
6h 12m1 stop
$405United Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5
United Airlines Logo
8:00 am - 5:55 pmDSM-BUF
8h 55m2 stops
United Airlines Logo
5:50 pm - 9:40 pmBUF-DSM
4h 50m1 stop
$482United Airlines
Find Deal
Fri, Jan 2 - Mon, Jan 5

Southwest flights from Des Moines to Buffalo

Our best Southwest deals on Des Moines to Buffalo flight tickets
Southwest
Dec 5
DSM8:20 amDes Moines
11h 20m
2 stops
BUF8:40 pmBuffalo
Dec 7
BUF10:50 amBuffalo
11h 10m
2 stops
DSM9:00 pmDes Moines
$349
Find similar
Southwest
Dec 5
DSM8:20 amDes Moines
11h 20m
2 stops
BUF8:40 pmBuffalo
Dec 7
BUF10:40 amBuffalo
11h 20m
1 stop
DSM9:00 pmDes Moines
$350
Find similar
Southwest
Aug 24
DSM6:10 amDes Moines
8h 20m
2 stops
BUF3:30 pmBuffalo
Aug 30
BUF7:10 amBuffalo
6h 15m
1 stop
DSM12:25 pmDes Moines
$362
Find similar

American Airlines flights from Des Moines to Buffalo

Our best American Airlines deals on Des Moines to Buffalo flight tickets
American Airlines
Aug 25
DSM12:44 pmDes Moines
4h 50m
1 stop
BUF6:34 pmBuffalo
Aug 27
BUF6:00 amBuffalo
7h 39m
2 stops
DSM12:39 pmDes Moines
$242
Find similar
American Airlines
Sep 16
DSM8:00 amDes Moines
8h 55m
2 stops
BUF5:55 pmBuffalo
Sep 23
BUF6:45 pmBuffalo
5h 21m
1 stop
DSM11:06 pmDes Moines
$243
Find similar
American Airlines
Oct 2
DSM5:00 amDes Moines
5h 06m
1 stop
BUF11:06 amBuffalo
Oct 5
BUF7:30 amBuffalo
7h 21m
1 stop
DSM1:51 pmDes Moines
$259
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 4, 2025.
Use the filters below to find and compare flights from Des Moines to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 12/4

6:20 am-11:43 am

1 stop4h 23m

Buffalo

Tue 12/9

6:00 am-10:18 am

1 stop5h 18m

$237

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Mon 8/25

12:44 pm-6:34 pm

1 stop4h 50m

Buffalo

Wed 8/27

6:00 am-12:39 pm

2 stops7h 39m

$242

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Tue 9/16

8:00 am-5:55 pm

2 stops8h 55m

Buffalo

Tue 9/23

6:45 pm-11:06 pm

1 stop5h 21m

$243

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 10/2

5:00 am-11:06 am

1 stop5h 06m

Buffalo

Sun 10/5

7:30 am-1:51 pm

1 stop7h 21m

$259

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Sun 9/7

6:11 pm-12:12 am

1 stop5h 01m

Buffalo

Fri 9/12

6:49 pm-11:06 pm

1 stop5h 17m

$281

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/5

5:25 pm-11:03 pm

1 stop4h 38m

Buffalo

Tue 12/9

10:15 am-4:02 pm

1 stop6h 47m

$288

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/5

8:20 am-8:40 pm

2 stops11h 20m

Buffalo

Sun 12/7

10:50 am-9:00 pm

2 stops11h 10m

$349

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 12/5

8:20 am-8:40 pm

2 stops11h 20m

Buffalo

Sun 12/7

10:40 am-9:00 pm

1 stop11h 20m

$350

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Thu 10/2

6:30 am-2:12 pm

2 stops6h 42m

Buffalo

Sun 10/5

7:07 am-12:19 pm

1 stop6h 12m

$405

Des MoinesBuffalo

DSM - BUF

DSMBUF

Des Moines

Fri 1/2

8:00 am-5:55 pm

2 stops8h 55m

Buffalo

Mon 1/5

5:50 pm-9:40 pm

1 stop4h 50m

$482

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $321. Flights from Des Moines to Buffalo on a Friday will generally be more expensive and average around $497. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the morning is the cheapest time of day to fly from Des Moines to Buffalo when you can find flight prices for as low as $356. Flying to Buffalo in the morning is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $452 per ticket.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Best Price Found

$119

Fastest flight time

3h 49m

Direct flights

None

Airports in Buffalo

1 airport
The best one-way flight to Buffalo from Des Moines in the past 72 hours is $119. The best round-trip flight deal from Des Moines to Buffalo found on momondo in the last 72 hours is $237.
The fastest flight from Des Moines to Buffalo takes 3h 49m
There are no direct flights from Des Moines to Buffalo. Popular non-direct route for this connection is Des Moines Airport - Buffalo Airport.
There is 1 airport near Buffalo: Buffalo (BUF)
Search flight deals

  • How far is Des Moines to Buffalo by plane?

    The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 3h 49m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

    Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

  • How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Buffalo?

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
8.0
7,987 reviews
Search Delta flights
American AirlinesPriceFrom $276Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $341Free CancellationRating
7.4
8,912 reviews
Search United Airlines flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Williamsville
Amherst
Tonawanda
Cheektowaga
Grand Island
Lockport
Orchard Park
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.

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