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Cheap flights from Denver to Florence from $519

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Florence departing on 11/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Denver to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:59 pm - 9:54 amDEN-FLO
7h 55m1 stop
American Airlines Logo
6:33 pm - 11:20 pmFLO-DEN
6h 47m1 stop
$519American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
American Airlines Logo
11:59 pm - 9:54 amDEN-FLO
7h 55m1 stop
American Airlines Logo
5:15 am - 1:55 pmFLO-DEN
10h 40m2 stops
$524American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
American Airlines Logo
10:24 am - 10:53 pmDEN-FLO
10h 29m2 stops
American Airlines Logo
11:11 am - 5:45 pmFLO-DEN
8h 34m2 stops
$529American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
American Airlines Logo
10:13 am - 6:07 pmDEN-FLO
5h 54m1 stop
American Airlines Logo
6:33 pm - 11:20 pmFLO-DEN
6h 47m1 stop
$561American Airlines
Find Deal
Thu, Nov 20 - Sun, Nov 23
American Airlines Logo
4:10 pm - 11:41 pmDEN-FLO
5h 31m1 stop
American Airlines Logo
5:15 am - 1:58 pmFLO-DEN
10h 43m2 stops
$566American Airlines
Find Deal
Thu, Nov 20 - Sun, Nov 23
American Airlines Logo
8:00 am - 6:07 pmDEN-FLO
8h 07m1 stop
American Airlines Logo
11:11 am - 5:52 pmFLO-DEN
8h 41m2 stops
$631American Airlines
Find Deal
Thu, Nov 20 - Sat, Nov 22
American Airlines Logo
6:00 am - 6:07 pmDEN-FLO
10h 07m2 stops
American Airlines Logo
5:15 am - 1:58 pmFLO-DEN
10h 43m2 stops
$655American Airlines
Find Deal
Thu, Nov 20 - Sun, Nov 23
American Airlines Logo
12:26 pm - 11:41 pmDEN-FLO
9h 15m2 stops
American Airlines Logo
11:11 am - 10:04 pmFLO-DEN
12h 53m2 stops
$720American Airlines
Find Deal
Thu, Nov 20 - Sat, Nov 22
American Airlines Logo
7:32 am - 11:38 pmDEN-FLO
14h 06m2 stops
American Airlines Logo
5:13 am - 10:19 pmFLO-DEN
19h 06m2 stops
$738American Airlines
Find Deal
Tue, Mar 31 - Wed, Apr 1
American Airlines Logo
7:15 am - 2:05 pmDEN-FLO
4h 50m1 stop
American Airlines Logo
11:09 am - 10:19 pmFLO-DEN
13h 10m2 stops
$838American Airlines
Find Deal
Tue, Mar 31 - Wed, Apr 1

American Airlines flights from Denver to Florence, South Carolina

Our best American Airlines deals on Denver to Florence, South Carolina flight tickets
American Airlines
Nov 4
DEN11:59 pmDenver Intl
7h 55m
1 stop
FLO9:54 amFlorence
Nov 8
FLO6:33 pmFlorence
6h 47m
1 stop
DEN11:20 pmDenver Intl
$519
Find similar
American Airlines
Nov 4
DEN11:59 pmDenver Intl
7h 55m
1 stop
FLO9:54 amFlorence
Nov 8
FLO5:15 amFlorence
10h 40m
2 stops
DEN1:55 pmDenver Intl
$524
Find similar
American Airlines
Nov 4
DEN10:24 amDenver Intl
10h 29m
2 stops
FLO10:53 pmFlorence
Nov 8
FLO11:11 amFlorence
8h 34m
2 stops
DEN5:45 pmDenver Intl
$529
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Denver to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 11/4

11:59 pm-9:54 am

1 stop7h 55m

Florence

Sat 11/8

6:33 pm-11:20 pm

1 stop6h 47m

$519

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 11/4

11:59 pm-9:54 am

1 stop7h 55m

Florence

Sat 11/8

5:15 am-1:55 pm

2 stops10h 40m

$524

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 11/4

10:24 am-10:53 pm

2 stops10h 29m

Florence

Sat 11/8

11:11 am-5:45 pm

2 stops8h 34m

$529

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 11/20

10:13 am-6:07 pm

1 stop5h 54m

Florence

Sun 11/23

6:33 pm-11:20 pm

1 stop6h 47m

$561

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 11/20

4:10 pm-11:41 pm

1 stop5h 31m

Florence

Sun 11/23

5:15 am-1:58 pm

2 stops10h 43m

$566

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 11/20

8:00 am-6:07 pm

1 stop8h 07m

Florence

Sat 11/22

11:11 am-5:52 pm

2 stops8h 41m

$631

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 11/20

6:00 am-6:07 pm

2 stops10h 07m

Florence

Sun 11/23

5:15 am-1:58 pm

2 stops10h 43m

$655

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 11/20

12:26 pm-11:41 pm

2 stops9h 15m

Florence

Sat 11/22

11:11 am-10:04 pm

2 stops12h 53m

$720

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 3/31

7:32 am-11:38 pm

2 stops14h 06m

Florence

Wed 4/1

5:13 am-10:19 pm

2 stops19h 06m

$738

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 3/31

7:15 am-2:05 pm

1 stop4h 50m

Florence

Wed 4/1

11:09 am-10:19 pm

2 stops13h 10m

$838

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Denver to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Denver is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $353. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from Denver because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $499.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from Denver to Florence, South Carolina in the morning for as low as $429. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $561 per ticket.

When to book flights from Denver to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Florence, South Carolina (DEN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Florence, South Carolina

Direct flights

None
There are no direct flights from Denver to Florence, South Carolina. There are no popular flight routes from Denver to Florence, South Carolina.
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  • How far is Denver Intl to Florence by plane?

    The straight-line distance from Denver Intl to Florence is 1437.7 mi. In terms of flight time, this usually takes a little over 4h 50m.

  • When did momondo last update prices for flights from Denver Intl Airport to Florence Airport?

    Prices for flights from Denver Intl Airport to Florence Airport refresh daily.

  • How many operators does momondo search for flights from Denver Intl Airport to Florence Airport?

  • How old do you have to be to fly from Denver Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Denver Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Denver to Florence, South Carolina?

Best airlines flying from Denver to Florence, South Carolina

Compare and see reviews for airlines that fly from Denver to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $365Free CancellationRating
7.2
11,024 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Florence?

Finding the right flight to Florence from Denver is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Denver to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Denver which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Denver to Florence?

momondo helps you find the best flight between Denver and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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