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Cheap flights from Denver to Florence from $329

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Denver to Florence departing on 8/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Denver to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:57 pm - 11:37 pm
DEN
-
FLO
5h 40m
1 stop
American Airlines Logo
3:22 pm - 7:19 pm
FLO
-
DEN
5h 57m
1 stop
$329American Airlines
Tue, Aug 4 - Sat, Aug 8
American Airlines Logo
6:15 am - 2:56 pm
DEN
-
FLO
6h 41m
1 stop
American Airlines Logo
3:22 pm - 7:19 pm
FLO
-
DEN
5h 57m
1 stop
$429American Airlines
Sat, Aug 8 - Sat, Aug 15
American Airlines Logo
6:30 am - 2:09 pm
DEN
-
FLO
5h 39m
1 stop
American Airlines Logo
2:34 pm - 8:22 pm
FLO
-
DEN
7h 48m
1 stop
$459American Airlines
Fri, Oct 23 - Fri, Oct 30
American Airlines Logo
1:20 pm - 10:59 pm
DEN
-
FLO
7h 39m
1 stop
American Airlines Logo
6:22 am - 4:53 pm
FLO
-
DEN
12h 31m
2 stops
$469American Airlines
Thu, Aug 13 - Thu, Aug 20
American Airlines Logo
7:16 am - 11:37 pm
DEN
-
FLO
14h 21m
2 stops
American Airlines Logo
3:22 pm - 7:19 pm
FLO
-
DEN
5h 57m
1 stop
$474American Airlines
Tue, Aug 4 - Sat, Aug 8
American Airlines Logo
8:00 am - 11:57 pm
DEN
-
FLO
13h 57m
2 stops
American Airlines Logo
2:34 pm - 8:22 pm
FLO
-
DEN
7h 48m
1 stop
$551American Airlines
Fri, Oct 23 - Fri, Oct 30
American Airlines Logo
2:19 pm - 11:57 pm
DEN
-
FLO
7h 38m
1 stop
American Airlines Logo
2:34 pm - 8:22 pm
FLO
-
DEN
7h 48m
1 stop
$560American Airlines
Fri, Oct 23 - Thu, Oct 29
American Airlines Logo
3:57 pm - 11:58 pm
DEN
-
FLO
6h 01m
1 stop
American Airlines Logo
6:22 am - 12:30 pm
FLO
-
DEN
8h 08m
1 stop
$573American Airlines
Sun, Aug 9 - Sat, Aug 15
American Airlines Logo
6:41 am - 2:10 pm
DEN
-
FLO
5h 29m
1 stop
American Airlines Logo
3:22 pm - 7:19 pm
FLO
-
DEN
5h 57m
1 stop
$574American Airlines
Sat, Aug 1 - Wed, Aug 5
American Airlines Logo
1:56 pm - 11:37 pm
DEN
-
FLO
7h 41m
1 stop
American Airlines Logo
3:22 pm - 7:19 pm
FLO
-
DEN
5h 57m
1 stop
$606American Airlines
Fri, Jul 31 - Wed, Aug 5

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American Airlines flights from Denver to Florence, South Carolina

Our best American Airlines deals on Denver to Florence, South Carolina flight tickets
American Airlines
Aug 17
DEN6:15 amDenver Intl
6h 41m
1 stop
FLO2:56 pmFlorence
Aug 24
FLO3:22 pmFlorence
5h 57m
1 stop
DEN7:19 pmDenver Intl
$329
American Airlines
Aug 8
DEN6:15 amDenver Intl
6h 41m
1 stop
FLO2:56 pmFlorence
Aug 15
FLO3:22 pmFlorence
5h 57m
1 stop
DEN7:19 pmDenver Intl
$429
American Airlines
Oct 23
DEN6:30 amDenver Intl
5h 39m
1 stop
FLO2:09 pmFlorence
Oct 30
FLO2:34 pmFlorence
7h 48m
1 stop
DEN8:22 pmDenver Intl
$459

momondo Fare Finder

 
Customize your flight search to find flights from Denver to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 19, 2026.
Use the filters below to find and compare flights from Denver to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 8/4

3:57 pm-11:37 pm

1 stop5h 40m

Florence

Sat 8/8

3:22 pm-7:19 pm

1 stop5h 57m

$329

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 8/8

6:15 am-2:56 pm

1 stop6h 41m

Florence

Sat 8/15

3:22 pm-7:19 pm

1 stop5h 57m

$429

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

6:30 am-2:09 pm

1 stop5h 39m

Florence

Fri 10/30

2:34 pm-8:22 pm

1 stop7h 48m

$459

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 8/13

1:20 pm-10:59 pm

1 stop7h 39m

Florence

Thu 8/20

6:22 am-4:53 pm

2 stops12h 31m

$469

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 8/4

7:16 am-11:37 pm

2 stops14h 21m

Florence

Sat 8/8

3:22 pm-7:19 pm

1 stop5h 57m

$474

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

8:00 am-11:57 pm

2 stops13h 57m

Florence

Fri 10/30

2:34 pm-8:22 pm

1 stop7h 48m

$551

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 10/23

2:19 pm-11:57 pm

1 stop7h 38m

Florence

Thu 10/29

2:34 pm-8:22 pm

1 stop7h 48m

$560

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 8/9

3:57 pm-11:58 pm

1 stop6h 01m

Florence

Sat 8/15

6:22 am-12:30 pm

1 stop8h 08m

$573
Quickest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sat 8/1

6:41 am-2:10 pm

1 stop5h 29m

Florence

Wed 8/5

3:22 pm-7:19 pm

1 stop5h 57m

$574

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 7/31

1:56 pm-11:37 pm

1 stop7h 41m

Florence

Wed 8/5

3:22 pm-7:19 pm

1 stop5h 57m

$606

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Denver to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Denver according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Denver to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Denver to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Denver to Florence, South Carolina (DEN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Denver to Florence, South Carolina

Fastest flight time

7h 41m

Direct flights

None
The fastest flight from Denver to Florence, South Carolina takes 7h 41m
There are no direct flights from Denver to Florence, South Carolina. There are no popular flight routes from Denver to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Denver to Florence, South Carolina

  • How far is Denver Intl to Florence by plane?

    The straight-line distance from Denver Intl to Florence is 1437.7 mi. In terms of flight time, this usually takes a little over 7h 41m.

  • When did momondo last update prices for flights from Denver Intl Airport to Florence Airport?

    Prices for flights from Denver Intl Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Denver Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Denver Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Denver to Florence?

Finding the right flight to Florence from Denver is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Denver to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Denver which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Denver to Florence?

momondo helps you find the best flight between Denver and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Denver to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Denver to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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