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Cheap flights from Columbus to Des Moines from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus to Des Moines departing on 7/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Columbus to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:50 pm - 10:45 pm
CMH
-
DSM
3h 55m
1 stop
Southwest Logo
5:20 am - 10:15 am
DSM
-
CMH
3h 55m
1 stop
$338Southwest
Wed, Jun 10 - Tue, Jun 16
Southwest Logo
7:50 pm - 10:45 pm
CMH
-
DSM
3h 55m
1 stop
Southwest Logo
5:20 am - 5:20 pm
DSM
-
CMH
11h 00m
2 stops
$343Southwest
Wed, Jun 10 - Tue, Jun 16
Southwest Logo
1:35 pm - 10:45 pm
CMH
-
DSM
10h 10m
2 stops
Southwest Logo
5:20 am - 5:20 pm
DSM
-
CMH
11h 00m
2 stops
$348Southwest
Wed, Jun 10 - Tue, Jun 16
American Airlines Logo
5:25 pm - 11:48 pm
CMH
-
DSM
7h 23m
1 stop
American Airlines Logo
6:34 pm - 12:02 am
DSM
-
CMH
4h 28m
1 stop
$356American Airlines
Sat, Sep 5 - Wed, Sep 9
Delta Logo
10:53 am - 4:54 pm
CMH
-
DSM
7h 01m
1 stop
Delta Logo
6:08 am - 1:27 pm
DSM
-
CMH
6h 19m
1 stop
$362Delta
Wed, Jun 17 - Sun, Jun 21
Southwest Logo
7:50 pm - 10:45 pm
CMH
-
DSM
3h 55m
1 stop
Southwest Logo
4:40 pm - 9:10 pm
DSM
-
CMH
3h 30m
1 stop
$363Southwest
Wed, Jun 10 - Mon, Jun 15
Southwest Logo
1:35 pm - 10:45 pm
CMH
-
DSM
10h 10m
2 stops
Southwest Logo
4:40 pm - 9:10 pm
DSM
-
CMH
3h 30m
1 stop
$368Southwest
Wed, Jun 10 - Mon, Jun 15
Southwest Logo
9:00 am - 11:30 am
CMH
-
DSM
3h 30m
1 stop
Southwest Logo
6:10 am - 6:00 pm
DSM
-
CMH
10h 50m
2 stops
$373Southwest
Sat, Sep 5 - Wed, Sep 9
Southwest Logo
8:10 pm - 11:30 pm
CMH
-
DSM
4h 20m
1 stop
Southwest Logo
4:40 pm - 9:10 pm
DSM
-
CMH
3h 30m
1 stop
$375Southwest
Mon, Jun 22 - Mon, Jul 6
Delta Logo
10:54 am - 4:47 pm
CMH
-
DSM
6h 53m
1 stop
Delta Logo
5:56 pm - 10:37 pm
DSM
-
CMH
3h 41m
1 stop
$381Delta
Thu, Aug 20 - Sun, Aug 23

Delta flights from Columbus to Des Moines

Our best Delta deals on Columbus to Des Moines flight tickets
Delta
Jun 17
CMH10:53 amColumbus
7h 01m
1 stop
DSM4:54 pmDes Moines
Jun 21
DSM6:08 amDes Moines
6h 19m
1 stop
CMH1:27 pmColumbus
$362
Delta
Aug 20
CMH10:54 amColumbus
6h 53m
1 stop
DSM4:47 pmDes Moines
Aug 23
DSM5:56 pmDes Moines
3h 41m
1 stop
CMH10:37 pmColumbus
$381
Delta
Aug 21
CMH6:00 amColumbus
5h 34m
1 stop
DSM10:34 amDes Moines
Aug 23
DSM2:45 pmDes Moines
6h 52m
1 stop
CMH10:37 pmColumbus
$387

Southwest flights from Columbus to Des Moines

Our best Southwest deals on Columbus to Des Moines flight tickets
Southwest
Jun 10
CMH7:50 pmColumbus
3h 55m
1 stop
DSM10:45 pmDes Moines
Jun 16
DSM5:20 amDes Moines
3h 55m
1 stop
CMH10:15 amColumbus
$338
Southwest
Jun 10
CMH7:50 pmColumbus
3h 55m
1 stop
DSM10:45 pmDes Moines
Jun 16
DSM5:20 amDes Moines
11h 00m
2 stops
CMH5:20 pmColumbus
$343
Southwest
Jun 10
CMH1:35 pmColumbus
10h 10m
2 stops
DSM10:45 pmDes Moines
Jun 16
DSM5:20 amDes Moines
11h 00m
2 stops
CMH5:20 pmColumbus
$348

momondo Fare Finder

 
Customize your flight search to find flights from Columbus to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Columbus to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/10

7:50 pm-10:45 pm

1 stop3h 55m

Des Moines

Tue 6/16

5:20 am-10:15 am

1 stop3h 55m

$338

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/10

7:50 pm-10:45 pm

1 stop3h 55m

Des Moines

Tue 6/16

5:20 am-5:20 pm

2 stops11h 00m

$343

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/10

1:35 pm-10:45 pm

2 stops10h 10m

Des Moines

Tue 6/16

5:20 am-5:20 pm

2 stops11h 00m

$348

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Sat 9/5

5:25 pm-11:48 pm

1 stop7h 23m

Des Moines

Wed 9/9

6:34 pm-12:02 am

1 stop4h 28m

$356

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/17

10:53 am-4:54 pm

1 stop7h 01m

Des Moines

Sun 6/21

6:08 am-1:27 pm

1 stop6h 19m

$362
Quickest round-trip

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/10

7:50 pm-10:45 pm

1 stop3h 55m

Des Moines

Mon 6/15

4:40 pm-9:10 pm

1 stop3h 30m

$363

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 6/10

1:35 pm-10:45 pm

2 stops10h 10m

Des Moines

Mon 6/15

4:40 pm-9:10 pm

1 stop3h 30m

$368

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Sat 9/5

9:00 am-11:30 am

1 stop3h 30m

Des Moines

Wed 9/9

6:10 am-6:00 pm

2 stops10h 50m

$373

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Mon 6/22

8:10 pm-11:30 pm

1 stop4h 20m

Des Moines

Mon 7/6

4:40 pm-9:10 pm

1 stop3h 30m

$375

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Thu 8/20

10:54 am-4:47 pm

1 stop6h 53m

Des Moines

Sun 8/23

5:56 pm-10:37 pm

1 stop3h 41m

$381

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Columbus to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Columbus and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in October, then May is your next best option. Flight prices from Columbus to Des Moines during May average around $216.

Cheap Columbus to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus to Des Moines

Fastest flight time

3h 38m

Direct flights

None
The fastest flight from Columbus to Des Moines takes 3h 38m
There are no direct flights from Columbus to Des Moines. There are no popular flight routes from Columbus to Des Moines.
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Frequently asked questions about flying from Columbus to Des Moines

  • How far is Columbus to Des Moines by plane?

    A flight from Columbus to Des Moines will travel around 566.8 mi. 3h 38m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Columbus to Des Moines Airport?

    Prices for flights from Columbus to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Columbus to Des Moines Airport?

  • How old do you have to be to fly from Columbus to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbus to Des Moines

Compare and see reviews for airlines that fly from Columbus to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,455 reviews
Search Delta flights
United AirlinesPriceFrom $249Free CancellationRating
7.4
9,727 reviews
Search United Airlines flights
SouthwestPriceFrom $367Free CancellationRating
8.0
4,296 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Columbus with this policy.

How can momondo help me find flights from Columbus to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Columbus. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbus to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Columbus are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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