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Cheap flights from Columbus to Des Moines from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus to Des Moines departing on 5/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbus to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:08 am - 4:31 pm
CMH
-
DSM
9h 23m
1 stop
American Airlines Logo
8:56 am - 2:12 pm
DSM
-
CMH
4h 16m
1 stop
$284American Airlines
Tue, Apr 21 - Thu, Apr 23
United Airlines Logo
10:39 am - 2:25 pm
CMH
-
DSM
4h 46m
1 stop
United Airlines Logo
1:10 pm - 11:40 pm
DSM
-
CMH
9h 30m
2 stops
$310United Airlines
Tue, Apr 21 - Thu, Apr 23
Delta Logo
6:41 pm - 10:32 pm
CMH
-
DSM
4h 51m
1 stop
Delta Logo
11:49 am - 5:34 pm
DSM
-
CMH
4h 45m
1 stop
$325Delta
Mon, May 11 - Thu, May 14
Multiple Airlines Logo
5:45 am - 9:25 am
CMH
-
DSM
28h 40m
1 stop
Multiple Airlines Logo
8:21 pm - 11:42 am
DSM
-
CMH
14h 21m
2 stops
$329Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
American Airlines Logo
6:00 am - 10:26 am
CMH
-
DSM
5h 26m
1 stop
American Airlines Logo
11:09 am - 5:45 pm
DSM
-
CMH
5h 36m
1 stop
$330American Airlines
Mon, May 11 - Thu, May 14
Multiple Airlines Logo
5:45 am - 9:25 am
CMH
-
DSM
28h 40m
1 stop
Multiple Airlines Logo
8:21 pm - 11:42 am
DSM
-
CMH
14h 21m
2 stops
$332Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
Multiple Airlines Logo
11:39 am - 10:51 pm
CMH
-
DSM
12h 12m
1 stop
Multiple Airlines Logo
7:00 am - 10:44 am
DSM
-
CMH
26h 44m
2 stops
$335Multiple Airlines
Thu, Mar 5 - Sun, Mar 8
Multiple Airlines Logo
5:45 am - 9:25 am
CMH
-
DSM
28h 40m
1 stop
Multiple Airlines Logo
8:21 pm - 11:42 am
DSM
-
CMH
14h 21m
2 stops
$338Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
Southwest Logo
4:10 pm - 10:10 pm
CMH
-
DSM
7h 00m
2 stops
Southwest Logo
5:25 am - 12:40 pm
DSM
-
CMH
6h 15m
2 stops
$341Southwest
Tue, Apr 21 - Thu, Apr 23
Multiple Airlines Logo
11:39 am - 2:18 pm
CMH
-
DSM
27h 39m
2 stops
Multiple Airlines Logo
7:27 pm - 7:28 pm
DSM
-
CMH
23h 01m
1 stop
$348Multiple Airlines
Wed, Feb 25 - Sun, Mar 1

American Airlines flights from Columbus to Des Moines

Our best American Airlines deals on Columbus to Des Moines flight tickets
American Airlines
Apr 21
CMH8:08 amColumbus
9h 23m
1 stop
DSM4:31 pmDes Moines
Apr 23
DSM8:56 amDes Moines
4h 16m
1 stop
CMH2:12 pmColumbus
$284
American Airlines
May 11
CMH6:00 amColumbus
5h 26m
1 stop
DSM10:26 amDes Moines
May 14
DSM11:09 amDes Moines
5h 36m
1 stop
CMH5:45 pmColumbus
$330
American Airlines
Apr 6
CMH3:45 pmColumbus
8h 57m
1 stop
DSM11:42 pmDes Moines
Apr 10
DSM8:56 amDes Moines
4h 16m
1 stop
CMH2:12 pmColumbus
$367

United Airlines flights from Columbus to Des Moines

Our best United Airlines deals on Columbus to Des Moines flight tickets
United Airlines
Apr 21
CMH10:39 amColumbus
4h 46m
1 stop
DSM2:25 pmDes Moines
Apr 23
DSM1:10 pmDes Moines
9h 30m
2 stops
CMH11:40 pmColumbus
$310
United Airlines
Mar 26
CMH6:00 amColumbus
9h 24m
2 stops
DSM2:24 pmDes Moines
Mar 29
DSM8:04 amDes Moines
4h 08m
1 stop
CMH1:12 pmColumbus
$351
United Airlines
Mar 6
CMH6:00 amColumbus
8h 23m
2 stops
DSM1:23 pmDes Moines
Mar 9
DSM6:49 pmDes Moines
3h 58m
1 stop
CMH11:47 pmColumbus
$361

momondo Fare Finder

 
Customize your flight search to find flights from Columbus to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Columbus to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/21

8:08 am-4:31 pm

1 stop9h 23m

Des Moines

Thu 4/23

8:56 am-2:12 pm

1 stop4h 16m

$284

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/21

10:39 am-2:25 pm

1 stop4h 46m

Des Moines

Thu 4/23

1:10 pm-11:40 pm

2 stops9h 30m

$310

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Mon 5/11

6:41 pm-10:32 pm

1 stop4h 51m

Des Moines

Thu 5/14

11:49 am-5:34 pm

1 stop4h 45m

$325

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Fri 3/6

5:45 am-9:25 am

1 stop28h 40m

Des Moines

Mon 3/9

8:21 pm-11:42 am

2 stops14h 21m

$329

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Mon 5/11

6:00 am-10:26 am

1 stop5h 26m

Des Moines

Thu 5/14

11:09 am-5:45 pm

1 stop5h 36m

$330

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Fri 3/6

5:45 am-9:25 am

1 stop28h 40m

Des Moines

Mon 3/9

8:21 pm-11:42 am

2 stops14h 21m

$332

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Thu 3/5

11:39 am-10:51 pm

1 stop12h 12m

Des Moines

Sun 3/8

7:00 am-10:44 am

2 stops26h 44m

$335

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Fri 3/6

5:45 am-9:25 am

1 stop28h 40m

Des Moines

Mon 3/9

8:21 pm-11:42 am

2 stops14h 21m

$338

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/21

4:10 pm-10:10 pm

2 stops7h 00m

Des Moines

Thu 4/23

5:25 am-12:40 pm

2 stops6h 15m

$341

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Wed 2/25

11:39 am-2:18 pm

2 stops27h 39m

Des Moines

Sun 3/1

7:27 pm-7:28 pm

1 stop23h 01m

$348

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Columbus to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then May is your next best option. Flight prices from Columbus to Des Moines during May average around $298.

Cheap Columbus to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus to Des Moines

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Columbus to Des Moines takes 4h 28m
There are no direct flights from Columbus to Des Moines. There are no popular flight routes from Columbus to Des Moines.
Search flight deals

  • How far is Columbus to Des Moines by plane?

    A flight from Columbus to Des Moines will travel around 566.8 mi. 4h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Columbus to Des Moines Airport?

    Prices for flights from Columbus to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Columbus to Des Moines Airport?

  • How old do you have to be to fly from Columbus to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbus to Des Moines

Compare and see reviews for airlines that fly from Columbus to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $143Free CancellationRating
7.9
8,186 reviews
Search Delta flights
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,275 reviews
Search American Airlines flights
United AirlinesPriceFrom $243Free CancellationRating
7.4
9,283 reviews
Search United Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,283 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Columbus with this policy.

How can momondo help me find flights from Columbus to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Columbus. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbus to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Columbus are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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