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Cheap flights from Columbus to Des Moines from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus to Des Moines departing on 4/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Columbus to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:08 pm - 1:09 pm
CMH
-
DSM
18h 01m
1 stop
Multiple Airlines Logo
2:36 pm - 11:05 am
DSM
-
CMH
19h 29m
2 stops
$276Multiple Airlines
Thu, Apr 30 - Sun, May 3
Delta Logo
8:33 am - 1:55 pm
CMH
-
DSM
6h 22m
1 stop
Delta Logo
5:45 pm - 12:05 am
DSM
-
CMH
5h 20m
1 stop
$299Delta
Tue, Apr 14 - Wed, Apr 15
United Airlines Logo
7:53 pm - 11:24 pm
CMH
-
DSM
4h 31m
1 stop
United Airlines Logo
7:05 pm - 1:28 am
DSM
-
CMH
5h 23m
1 stop
$301United Airlines
Tue, May 12 - Wed, May 13
United Airlines Logo
10:39 am - 2:25 pm
CMH
-
DSM
4h 46m
1 stop
United Airlines Logo
6:20 am - 2:11 pm
DSM
-
CMH
6h 51m
2 stops
$304United Airlines
Tue, Apr 14 - Wed, Apr 15
Delta Logo
7:10 am - 10:16 am
CMH
-
DSM
4h 06m
1 stop
Delta Logo
6:31 pm - 12:43 am
DSM
-
CMH
5h 12m
1 stop
$307Delta
Fri, Apr 17 - Fri, Apr 17
Delta Logo
7:12 am - 11:05 am
CMH
-
DSM
4h 53m
1 stop
Delta Logo
6:31 pm - 12:43 am
DSM
-
CMH
5h 12m
1 stop
$308Delta
Tue, Apr 21 - Wed, Apr 22
Southwest Logo
7:15 am - 2:05 pm
CMH
-
DSM
7h 50m
2 stops
Southwest Logo
5:30 am - 12:40 pm
DSM
-
CMH
6h 10m
2 stops
$311Southwest
Tue, Apr 14 - Wed, Apr 15
United Airlines Logo
6:10 am - 12:29 pm
CMH
-
DSM
7h 19m
2 stops
United Airlines Logo
7:16 pm - 11:59 pm
DSM
-
CMH
3h 43m
1 stop
$312United Airlines
Fri, Apr 17 - Fri, Apr 17
United Airlines Logo
5:36 am - 9:23 am
CMH
-
DSM
4h 47m
1 stop
United Airlines Logo
7:05 pm - 1:13 am
DSM
-
CMH
5h 08m
1 stop
$326United Airlines
Thu, Apr 30 - Sun, May 3
United Airlines Logo
10:38 am - 11:44 pm
CMH
-
DSM
14h 06m
2 stops
United Airlines Logo
7:05 pm - 11:59 pm
DSM
-
CMH
3h 54m
1 stop
$327United Airlines
Tue, May 12 - Wed, May 13

Southwest flights from Columbus to Des Moines

Our best Southwest deals on Columbus to Des Moines flight tickets
Southwest
Apr 14
CMH7:15 amColumbus
7h 50m
2 stops
DSM2:05 pmDes Moines
Apr 15
DSM5:30 amDes Moines
6h 10m
2 stops
CMH12:40 pmColumbus
$311
Southwest
Jun 7
CMH8:05 pmColumbus
4h 40m
1 stop
DSM11:45 pmDes Moines
Jun 8
DSM4:40 pmDes Moines
5h 50m
2 stops
CMH11:30 pmColumbus
$350
Southwest
Jun 7
CMH4:40 pmColumbus
8h 05m
2 stops
DSM11:45 pmDes Moines
Jun 8
DSM4:40 pmDes Moines
5h 50m
2 stops
CMH11:30 pmColumbus
$355

Delta flights from Columbus to Des Moines

Our best Delta deals on Columbus to Des Moines flight tickets
Delta
Apr 14
CMH8:33 amColumbus
6h 22m
1 stop
DSM1:55 pmDes Moines
Apr 15
DSM5:45 pmDes Moines
5h 20m
1 stop
CMH12:05 amColumbus
$299
Delta
Apr 17
CMH7:10 amColumbus
4h 06m
1 stop
DSM10:16 amDes Moines
Apr 17
DSM6:31 pmDes Moines
5h 12m
1 stop
CMH12:43 amColumbus
$307
Delta
Apr 21
CMH7:12 amColumbus
4h 53m
1 stop
DSM11:05 amDes Moines
Apr 22
DSM6:31 pmDes Moines
5h 12m
1 stop
CMH12:43 amColumbus
$308

momondo Fare Finder

 
Customize your flight search to find flights from Columbus to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from Columbus to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Thu 4/30

8:08 pm-1:09 pm

1 stop18h 01m

Des Moines

Sun 5/3

2:36 pm-11:05 am

2 stops19h 29m

$276

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/14

8:33 am-1:55 pm

1 stop6h 22m

Des Moines

Wed 4/15

5:45 pm-12:05 am

1 stop5h 20m

$299

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 5/12

7:53 pm-11:24 pm

1 stop4h 31m

Des Moines

Wed 5/13

7:05 pm-1:28 am

1 stop5h 23m

$301

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/14

10:39 am-2:25 pm

1 stop4h 46m

Des Moines

Wed 4/15

6:20 am-2:11 pm

2 stops6h 51m

$304
Quickest round-trip

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Fri 4/17

7:10 am-10:16 am

1 stop4h 06m

Des Moines

Fri 4/17

6:31 pm-12:43 am

1 stop5h 12m

$307

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/21

7:12 am-11:05 am

1 stop4h 53m

Des Moines

Wed 4/22

6:31 pm-12:43 am

1 stop5h 12m

$308

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 4/14

7:15 am-2:05 pm

2 stops7h 50m

Des Moines

Wed 4/15

5:30 am-12:40 pm

2 stops6h 10m

$311

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Fri 4/17

6:10 am-12:29 pm

2 stops7h 19m

Des Moines

Fri 4/17

7:16 pm-11:59 pm

1 stop3h 43m

$312

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Thu 4/30

5:36 am-9:23 am

1 stop4h 47m

Des Moines

Sun 5/3

7:05 pm-1:13 am

1 stop5h 08m

$326

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 5/12

10:38 am-11:44 pm

2 stops14h 06m

Des Moines

Wed 5/13

7:05 pm-11:59 pm

1 stop3h 54m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Columbus to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Columbus and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then May is your next best option. Flight prices from Columbus to Des Moines during May average around $287.

Cheap Columbus to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus to Des Moines

Fastest flight time

4h 10m

Direct flights

None
The fastest flight from Columbus to Des Moines takes 4h 10m
There are no direct flights from Columbus to Des Moines. There are no popular flight routes from Columbus to Des Moines.
Search flight deals

  • How far is Columbus to Des Moines by plane?

    A flight from Columbus to Des Moines will travel around 566.8 mi. 4h 10m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Columbus to Des Moines Airport?

    Prices for flights from Columbus to Des Moines Airport are updated daily.

  • How many operators does momondo search for flights from Columbus to Des Moines Airport?

  • How old do you have to be to fly from Columbus to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Columbus to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from Columbus to Des Moines

Compare and see reviews for airlines that fly from Columbus to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $228Free CancellationRating
7.1
11,543 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,364 reviews
Search Delta flights
United AirlinesPriceFrom $249Free CancellationRating
7.4
9,525 reviews
Search United Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,332 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Columbus to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Columbus to Des Moines with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Des Moines from Columbus with this policy.

How can momondo help me find flights from Columbus to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Columbus. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbus to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Columbus are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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