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Cheap flights from Chicago to Missouri from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Missouri departing on 12/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Contour Logo
11:50 am - 1:25 pmORD-CGI
1h 35mnonstop
Contour Logo
9:30 am - 11:10 amCGI-ORD
1h 40mnonstop
$126Contour
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Tue, Nov 18 - Sat, Nov 22
Southwest Logo
11:25 am - 12:35 pmMDW-STL
1h 10mnonstop
Southwest Logo
3:20 pm - 8:00 pmSTL-MDW
4h 40m1 stop
$127Southwest
Find Deal
Tue, Dec 9 - Tue, Dec 9
United Airlines Logo
1:00 pm - 2:29 pmORD-STL
1h 29mnonstop
United Airlines Logo
8:21 am - 9:54 amSTL-ORD
1h 33mnonstop
$127United Airlines
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Thu, Feb 12 - Sat, Feb 14
Frontier Logo
6:00 am - 9:07 amORD-STL
27h 07m1 stop
Frontier Logo
3:14 pm - 12:08 amSTL-ORD
8h 54m1 stop
$129Frontier
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Mon, Nov 17 - Thu, Nov 20
Frontier Logo
7:51 pm - 10:02 amORD-STL
14h 11m1 stop
Frontier Logo
10:42 am - 12:01 amSTL-ORD
13h 19m1 stop
$142Frontier
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Thu, Jan 8 - Sun, Jan 11
United Airlines Logo
2:14 pm - 3:40 pmORD-STL
1h 26mnonstop
United Airlines Logo
6:42 pm - 8:12 pmSTL-ORD
1h 30mnonstop
$144United Airlines
Find Deal
Tue, Dec 9 - Wed, Dec 10
American Airlines Logo
11:12 am - 12:44 pmORD-STL
1h 32mnonstop
American Airlines Logo
5:40 pm - 7:20 pmSTL-ORD
1h 40mnonstop
$156American Airlines
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Tue, Dec 9 - Tue, Dec 9
Delta Logo
6:46 pm - 11:25 pmORD-STL
4h 39m1 stop
Delta Logo
6:35 am - 1:07 pmSTL-ORD
6h 32m1 stop
$157Delta
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Sat, Jan 17 - Sun, Jan 18
Delta Logo
1:35 pm - 8:41 pmORD-STL
7h 06m1 stop
Delta Logo
11:23 am - 9:04 pmSTL-ORD
9h 41m2 stops
$162Delta
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Wed, Dec 31 - Tue, Jan 13
American Airlines Logo
2:48 pm - 4:19 pmORD-STL
1h 31mnonstop
American Airlines Logo
5:15 am - 6:45 amSTL-ORD
1h 30mnonstop
$170American Airlines
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Thu, Dec 4 - Mon, Dec 8

Southwest flights from Chicago to Missouri

Our best Southwest deals on Chicago to Missouri flight tickets
Southwest
Dec 9
MDW11:25 amChicago Midway
1h 10m
STL12:35 pmLambert-St Louis
Dec 9
STL3:20 pmLambert-St Louis
4h 40m
1 stop
MDW8:00 pmChicago Midway
$127
Find similar
Southwest
Dec 9
MDW6:20 amChicago Midway
1h 15m
STL7:35 amLambert-St Louis
Dec 9
STL10:35 amLambert-St Louis
6h 15m
2 stops
MDW4:50 pmChicago Midway
$132
Find similar
Southwest
Dec 9
MDW9:05 pmChicago Midway
1h 15m
STL10:20 pmLambert-St Louis
Dec 11
STL7:35 pmLambert-St Louis
1h 10m
MDW8:45 pmChicago Midway
$144
Find similar

United Airlines flights from Chicago to Missouri

Our best United Airlines deals on Chicago to Missouri flight tickets
United Airlines
Feb 12
ORD1:00 pmChicago O'Hare Intl
1h 29m
STL2:29 pmLambert-St Louis
Feb 14
STL8:21 amLambert-St Louis
1h 33m
ORD9:54 amChicago O'Hare Intl
$127
Find similar
United Airlines
Dec 9
ORD2:14 pmChicago O'Hare Intl
1h 26m
STL3:40 pmLambert-St Louis
Dec 10
STL6:42 pmLambert-St Louis
1h 30m
ORD8:12 pmChicago O'Hare Intl
$144
Find similar
United Airlines
Jan 14
ORD1:00 pmChicago O'Hare Intl
1h 30m
STL2:30 pmLambert-St Louis
Jan 17
STL11:20 amLambert-St Louis
1h 35m
ORD12:55 pmChicago O'Hare Intl
$167
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Chicago to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoCape Girardeau

ORD - CGI

ORDCGI

Chicago O'Hare Intl

Tue 11/18

11:50 am-1:25 pm

Nonstop1h 35m

Cape Girardeau

Sat 11/22

9:30 am-11:10 am

Nonstop1h 40m

$126

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Tue 12/9

11:25 am-12:35 pm

Nonstop1h 10m

Lambert-St Louis

Tue 12/9

3:20 pm-8:00 pm

1 stop4h 40m

$127

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 2/12

1:00 pm-2:29 pm

Nonstop1h 29m

Lambert-St Louis

Sat 2/14

8:21 am-9:54 am

Nonstop1h 33m

$127

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Mon 11/17

6:00 am-9:07 am

1 stop27h 07m

Lambert-St Louis

Thu 11/20

3:14 pm-12:08 am

1 stop8h 54m

$129

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 1/8

7:51 pm-10:02 am

1 stop14h 11m

Lambert-St Louis

Sun 1/11

10:42 am-12:01 am

1 stop13h 19m

$142

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Tue 12/9

2:14 pm-3:40 pm

Nonstop1h 26m

Lambert-St Louis

Wed 12/10

6:42 pm-8:12 pm

Nonstop1h 30m

$144

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Tue 12/9

11:12 am-12:44 pm

Nonstop1h 32m

Lambert-St Louis

Tue 12/9

5:40 pm-7:20 pm

Nonstop1h 40m

$156

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Sat 1/17

6:46 pm-11:25 pm

1 stop4h 39m

Lambert-St Louis

Sun 1/18

6:35 am-1:07 pm

1 stop6h 32m

$157

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 12/31

1:35 pm-8:41 pm

1 stop7h 06m

Lambert-St Louis

Tue 1/13

11:23 am-9:04 pm

2 stops9h 41m

$162

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 12/4

2:48 pm-4:19 pm

Nonstop1h 31m

Lambert-St Louis

Mon 12/8

5:15 am-6:45 am

Nonstop1h 30m

$170

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Chicago to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, August is the cheapest month to fly from Chicago to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $257. If you aren’t able to travel to Missouri during the month of August, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $269.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Chicago to Missouri is on a Thursday when prices can be found for as low as $297. Flights from Chicago to Missouri on a Monday will generally be more expensive and average around $446. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Chicago to Missouri at noon for as low as $305. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the afternoon, with an average ticket price of $428. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago to Missouri flight route?

Fly from Chicago O'Hare Intl to Cape Girardeau for the best Chicago - Missouri flight prices

How far in advance should I book a flight to Missouri?

You are more likely to see cheaper flights to Missouri from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $275 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Chicago for as low as $142 on momondo.

What cabin class options are available on Chicago to Missouri flights?

There are 4 cabin classes available to choose from on Chicago to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Missouri flights?

No. A direct flight is the cheapest option for a flight between Chicago to Missouri.

Cheap Chicago to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Missouri

Best Price Found

$64

Fastest flight time

1h 10m

Direct flights

Every day

Airports in Missouri

3 airports
The best one-way flight to Missouri from Chicago in the past 72 hours is $64. The best round-trip flight deal from Chicago to Missouri found on momondo in the last 72 hours is $129.
The fastest flight from Chicago to Missouri takes 1h 10m
Direct flights go from Chicago to Missouri every day.
There are 3 airports near Missouri: Kansas City (MCI), Columbia Regional (COU), Lambert-St Louis (STL)
Search flight deals

  • When did momondo last update prices for flights from Chicago to Missouri?

    Prices for flights from Chicago to Missouri were last updated today.

  • How many operators does momondo search for flights from Chicago to Missouri?

  • How old do you have to be to fly from Chicago to Missouri?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Chicago to Missouri?

Best airlines flying from Chicago to Missouri

Compare and see reviews for airlines that fly from Chicago to Missouri with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,237 reviews
Search Southwest flights
ContourPriceFrom $114Free CancellationRating
7.5
40 reviews
Search Contour flights
American AirlinesPriceFrom $115Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
Southern / MokulelePriceFrom $145Free CancellationRating
0.0
0 reviews
Search Southern / Mokulele flights
United AirlinesPriceFrom $152Free CancellationRating
7.4
8,999 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Missouri?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Missouri. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Missouri with flexible booking policies on momondo?

Flights from Chicago to Missouri with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Missouri?

momondo provides multiple filters to help you find the best flight to Missouri from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Missouri right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Chicago to Missouri now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Missouri and let you know when they change.

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