Cheap flights from Chicago to Missouri from $59

In general, October is the cheapest month to fly from Chicago to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $299. If you aren’t able to travel to Missouri during the month of October, then flying in December is also cheap. Prices for this month can be found on momondo for an average of $316.

The cheapest day to depart from Chicago to Missouri is on a Saturday when prices can be found for as low as $294. Flights from Chicago to Missouri on a Monday will generally be more expensive and average around $543. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

According to our data, the cheapest time of day to fly to Missouri is at noon. momondo users have found flights departing from Chicago to Missouri at noon for as low as $357. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the afternoon, with an average ticket price of $524. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Chicago O'Hare Intl to Lambert-St Louis for the best Chicago - Missouri flight prices

You are more likely to see cheaper flights to Missouri from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $442 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Chicago for as low as $167 on momondo.

There are 4 cabin classes available to choose from on Chicago to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, Delta, and Contour are the most popular carriers operating from Chicago to Missouri

United Airlines, American Airlines and Southwest are the top three most popular airlines that fly to Missouri from Chicago according to our data. United Airlines is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 5 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

As of September 2026, there are 105 flights per day flying from Chicago to Missouri. The most common time of day flights depart is 5:00PM, with 43% of flights taking off in the afternoon.

736 flights are operational weekly from Chicago to Missouri as of September 2026. The most popular departure day for this route is Sun, with 21% of flights per week taking off on this day.