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Cheap flights from Chicago to Missouri from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Missouri departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Chicago to Missouri

Cheap round-trip flights

Southwest Logo
9:40 am - 10:55 amMDW-STL
1h 15mnonstop
Southwest Logo
5:40 am - 6:50 amSTL-MDW
1h 10mnonstop
$97Southwest
Find Deal
Thu, Oct 9 - Mon, Oct 13
American Airlines Logo
12:21 pm - 1:44 pmORD-STL
1h 23mnonstop
American Airlines Logo
7:16 am - 8:43 amSTL-ORD
1h 27mnonstop
$97American Airlines
Find Deal
Tue, Oct 21 - Mon, Oct 27
American Airlines Logo
6:53 pm - 8:26 pmORD-STL
1h 33mnonstop
American Airlines Logo
6:00 am - 7:23 amSTL-ORD
1h 23mnonstop
$98American Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
Southwest Logo
9:40 am - 10:55 amMDW-STL
1h 15mnonstop
Southwest Logo
6:45 pm - 11:15 pmSTL-MDW
4h 30m1 stop
$107Southwest
Find Deal
Thu, Oct 9 - Mon, Oct 13
United Airlines Logo
2:20 pm - 3:44 pmORD-STL
1h 24mnonstop
United Airlines Logo
5:28 pm - 6:53 pmSTL-ORD
1h 25mnonstop
$134United Airlines
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Wed, Oct 22 - Fri, Oct 24
United Airlines Logo
2:20 pm - 3:44 pmORD-STL
1h 24mnonstop
United Airlines Logo
9:20 am - 10:50 amSTL-ORD
1h 30mnonstop
$146United Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
Contour Logo
4:30 pm - 6:05 pmORD-CGI
1h 35mnonstop
Contour Logo
9:30 am - 11:10 amCGI-ORD
1h 40mnonstop
$158Contour
Find Deal
Wed, Oct 8 - Mon, Oct 13
Contour Logo
4:30 pm - 6:05 pmORD-CGI
1h 35mnonstop
Contour Logo
9:30 am - 11:10 amCGI-ORD
1h 40mnonstop
$161Contour
Find Deal
Fri, Oct 3 - Tue, Oct 7
Southern / Mokulele Logo
1:10 pm - 4:35 pmORD-STL
3h 25m1 stop
Southern / Mokulele Logo
9:20 am - 7:24 amSTL-ORD
22h 04m1 stop
$167Southern / Mokulele
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Tue, Oct 14 - Tue, Oct 21
Southern / Mokulele Logo
1:10 pm - 12:00 pmORD-STL
22h 50m1 stop
Southern / Mokulele Logo
1:00 pm - 7:24 amSTL-ORD
18h 24m1 stop
$168Southern / Mokulele
Find Deal
Thu, Oct 2 - Sun, Oct 5

Southern / Mokulele flights from Chicago to Missouri

Our best Southern / Mokulele deals on Chicago to Missouri flight tickets
Southern / Mokulele
Oct 14
ORD1:10 pmChicago O'Hare Intl
3h 25m
1 stop
STL4:35 pmLambert-St Louis
Oct 21
STL9:20 amLambert-St Louis
22h 04m
1 stop
ORD7:24 amChicago O'Hare Intl
$167
Find similar
Southern / Mokulele
Oct 2
ORD1:10 pmChicago O'Hare Intl
22h 50m
1 stop
STL12:00 pmLambert-St Louis
Oct 5
STL1:00 pmLambert-St Louis
18h 24m
1 stop
ORD7:24 amChicago O'Hare Intl
$168
Find similar
Southern / Mokulele
Oct 12
ORD1:10 pmChicago O'Hare Intl
3h 25m
1 stop
STL4:35 pmLambert-St Louis
Oct 13
STL1:00 pmLambert-St Louis
3h 19m
1 stop
ORD4:19 pmChicago O'Hare Intl
$169
Find similar

Frontier flights from Chicago to Missouri

Our best Frontier deals on Chicago to Missouri flight tickets
Frontier
Oct 31
ORD5:25 amChicago O'Hare Intl
7h 52m
1 stop
STL1:17 pmLambert-St Louis
Oct 31
STL4:52 pmLambert-St Louis
6h 47m
1 stop
ORD11:39 pmChicago O'Hare Intl
$139
Find similar
Frontier
Oct 21
ORD7:15 amChicago O'Hare Intl
25h 52m
1 stop
STL9:07 amLambert-St Louis
Oct 25
STL7:52 pmLambert-St Louis
13h 44m
1 stop
ORD9:36 amChicago O'Hare Intl
$140
Find similar
Frontier
Nov 6
ORD5:01 amChicago O'Hare Intl
5h 11m
1 stop
STL10:12 amLambert-St Louis
Nov 7
STL4:56 pmLambert-St Louis
7h 15m
1 stop
ORD12:11 amChicago O'Hare Intl
$143
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 18, 2025.
Use the filters below to find and compare flights from Chicago to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 10/9

9:40 am-10:55 am

Nonstop1h 15m

Lambert-St Louis

Mon 10/13

5:40 am-6:50 am

Nonstop1h 10m

$97

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Tue 10/21

12:21 pm-1:44 pm

Nonstop1h 23m

Lambert-St Louis

Mon 10/27

7:16 am-8:43 am

Nonstop1h 27m

$97

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 10/9

6:53 pm-8:26 pm

Nonstop1h 33m

Lambert-St Louis

Mon 10/13

6:00 am-7:23 am

Nonstop1h 23m

$98

ChicagoSt. Louis

MDW - STL

MDWSTL

Chicago Midway

Thu 10/9

9:40 am-10:55 am

Nonstop1h 15m

Lambert-St Louis

Mon 10/13

6:45 pm-11:15 pm

1 stop4h 30m

$107

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Wed 10/22

2:20 pm-3:44 pm

Nonstop1h 24m

Lambert-St Louis

Fri 10/24

5:28 pm-6:53 pm

Nonstop1h 25m

$134

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 10/9

2:20 pm-3:44 pm

Nonstop1h 24m

Lambert-St Louis

Mon 10/13

9:20 am-10:50 am

Nonstop1h 30m

$146

ChicagoCape Girardeau

ORD - CGI

ORDCGI

Chicago O'Hare Intl

Wed 10/8

4:30 pm-6:05 pm

Nonstop1h 35m

Cape Girardeau

Mon 10/13

9:30 am-11:10 am

Nonstop1h 40m

$158

ChicagoCape Girardeau

ORD - CGI

ORDCGI

Chicago O'Hare Intl

Fri 10/3

4:30 pm-6:05 pm

Nonstop1h 35m

Cape Girardeau

Tue 10/7

9:30 am-11:10 am

Nonstop1h 40m

$161

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Tue 10/14

1:10 pm-4:35 pm

1 stop3h 25m

Lambert-St Louis

Tue 10/21

9:20 am-7:24 am

1 stop22h 04m

$167

ChicagoSt. Louis

ORD - STL

ORDSTL

Chicago O'Hare Intl

Thu 10/2

1:10 pm-12:00 pm

1 stop22h 50m

Lambert-St Louis

Sun 10/5

1:00 pm-7:24 am

1 stop18h 24m

$168

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Chicago to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, August is the cheapest month to fly from Chicago to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $257. If you aren’t able to travel to Missouri during the month of August, then flying in April is also cheap. Prices for this month can be found on momondo for an average of $269.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Chicago to Missouri is on a Friday when prices can be found for as low as $277. Flights from Chicago to Missouri on a Monday will generally be more expensive and average around $453. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the evening. momondo users have found flights departing from Chicago to Missouri in the evening for as low as $277. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $331. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago to Missouri flight route?

Fly from Chicago O'Hare Intl to Lambert-St Louis for the best Chicago - Missouri flight prices

How far in advance should I book a flight to Missouri?

You are more likely to see cheaper flights to Missouri from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Missouri for around $283 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Missouri from Chicago for as low as $142 on momondo.

What cabin class options are available on Chicago to Missouri flights?

There are 4 cabin classes available to choose from on Chicago to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Missouri flights?

No. A direct flight is the cheapest option for a flight between Chicago to Missouri.

Cheap Chicago to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Missouri

Best Price Found

$81

Fastest flight time

1h 10m

Direct flights

Every day

Airports in Missouri

2 airports
The best one-way flight to Missouri from Chicago in the past 72 hours is $81. The best round-trip flight deal from Chicago to Missouri found on momondo in the last 72 hours is $138.
The fastest flight from Chicago to Missouri takes 1h 10m
Direct flights go from Chicago to Missouri every day.
There are 2 airports near Missouri: Columbia Regional (COU), Lambert-St Louis (STL)
Search flight deals

  • When did momondo last update prices for flights from Chicago to Missouri?

    Prices for flights from Chicago to Missouri were last updated today.

  • How many operators does momondo search for flights from Chicago to Missouri?

  • How old do you have to be to fly from Chicago to Missouri?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Chicago to Missouri?

Best airlines flying from Chicago to Missouri

Compare and see reviews for airlines that fly from Chicago to Missouri with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
ContourPriceFrom $114Free CancellationRating
7.2
36 reviews
Search Contour flights
American AirlinesPriceFrom $116Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Southern / MokulelePriceFrom $118Free CancellationRating
6.3
25 reviews
Search Southern / Mokulele flights
United AirlinesPriceFrom $152Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Missouri?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Missouri. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Missouri with flexible booking policies on momondo?

Flights from Chicago to Missouri with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Missouri?

momondo provides multiple filters to help you find the best flight to Missouri from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Missouri right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Chicago to Missouri now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Missouri and let you know when they change.

An easier way to manage your Missouri trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Sat 10/18
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