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Cheap flights from Chicago to Knoxville from $53

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Knoxville departing on 11/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Allegiant Air Logo
2:45 pm - 5:09 pmMDW-TYS
1h 24mnonstop
Allegiant Air Logo
7:02 pm - 7:34 pmTYS-MDW
1h 32mnonstop
$125Allegiant Air
Find Deal
Fri, Oct 24 - Mon, Oct 27
Allegiant Air Logo
2:45 pm - 5:09 pmMDW-TYS
1h 24mnonstop
Allegiant Air Logo
7:02 pm - 7:34 pmTYS-MDW
1h 32mnonstop
$127Allegiant Air
Find Deal
Fri, Oct 24 - Mon, Oct 27
Multiple Airlines Logo
2:57 pm - 5:22 pmMDW-TYS
1h 25mnonstop
Multiple Airlines Logo
2:22 pm - 8:31 pmTYS-MDW
7h 09m1 stop
$181Multiple Airlines
Find Deal
Fri, Nov 7 - Mon, Nov 17
Multiple Airlines Logo
2:57 pm - 5:22 pmMDW-TYS
1h 25mnonstop
Multiple Airlines Logo
7:17 pm - 11:30 amTYS-MDW
17h 13m1 stop
$184Multiple Airlines
Find Deal
Fri, Nov 7 - Thu, Nov 13
American Airlines Logo
2:07 pm - 4:53 pmORD-TYS
1h 46mnonstop
American Airlines Logo
7:59 am - 9:05 amTYS-ORD
2h 06mnonstop
$189American Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
American Airlines Logo
9:43 am - 12:31 pmORD-TYS
1h 48mnonstop
American Airlines Logo
6:16 pm - 7:20 pmTYS-ORD
2h 04mnonstop
$190American Airlines
Find Deal
Wed, Oct 29 - Wed, Nov 5
United Airlines Logo
8:00 pm - 10:50 pmORD-TYS
1h 50mnonstop
United Airlines Logo
7:00 am - 7:55 amTYS-ORD
1h 55mnonstop
$192United Airlines
Find Deal
Sun, Oct 12 - Sun, Oct 19
United Airlines Logo
8:00 pm - 10:50 pmORD-TYS
1h 50mnonstop
United Airlines Logo
7:00 am - 7:55 amTYS-ORD
1h 55mnonstop
$194United Airlines
Find Deal
Fri, Oct 3 - Tue, Oct 7
Delta Logo
1:25 pm - 9:13 pmORD-TYS
6h 48m1 stop
Delta Logo
8:05 pm - 12:01 amTYS-ORD
4h 56m1 stop
$209Delta
Find Deal
Sat, Nov 8 - Fri, Nov 14
Delta Logo
9:25 am - 4:55 pmORD-TYS
6h 30m1 stop
Delta Logo
8:10 pm - 11:58 pmTYS-ORD
4h 48m1 stop
$214Delta
Find Deal
Thu, Oct 2 - Mon, Oct 6

Allegiant Air flights from Chicago to Knoxville

Our best Allegiant Air deals on Chicago to Knoxville flight tickets
Allegiant Air
Oct 24
MDW2:45 pmChicago Midway
1h 24m
TYS5:09 pmKnoxville McGhee Tyson
Oct 27
TYS7:02 pmKnoxville McGhee Tyson
1h 32m
MDW7:34 pmChicago Midway
$125
Find similar
Allegiant Air
Sep 19
MDW7:50 pmChicago Midway
1h 31m
TYS10:21 pmKnoxville McGhee Tyson
Sep 26
TYS6:24 pmKnoxville McGhee Tyson
1h 36m
MDW7:00 pmChicago Midway
$126
Find similar
Allegiant Air
Oct 24
MDW2:45 pmChicago Midway
1h 24m
TYS5:09 pmKnoxville McGhee Tyson
Oct 27
TYS7:02 pmKnoxville McGhee Tyson
1h 32m
MDW7:34 pmChicago Midway
$127
Find similar

United Airlines flights from Chicago to Knoxville

Our best United Airlines deals on Chicago to Knoxville flight tickets
United Airlines
Oct 12
ORD8:00 pmChicago O'Hare Intl
1h 50m
TYS10:50 pmKnoxville McGhee Tyson
Oct 19
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$192
Find similar
United Airlines
Oct 3
ORD8:00 pmChicago O'Hare Intl
1h 50m
TYS10:50 pmKnoxville McGhee Tyson
Oct 7
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$194
Find similar
United Airlines
Oct 7
ORD7:15 amChicago O'Hare Intl
1h 55m
TYS10:10 amKnoxville McGhee Tyson
Oct 17
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$211
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Chicago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 10/24

2:45 pm-5:09 pm

Nonstop1h 24m

Knoxville McGhee Tyson

Mon 10/27

7:02 pm-7:34 pm

Nonstop1h 32m

$125

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 10/24

2:45 pm-5:09 pm

Nonstop1h 24m

Knoxville McGhee Tyson

Mon 10/27

7:02 pm-7:34 pm

Nonstop1h 32m

$127

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 11/7

2:57 pm-5:22 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Mon 11/17

2:22 pm-8:31 pm

1 stop7h 09m

$181

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Fri 11/7

2:57 pm-5:22 pm

Nonstop1h 25m

Knoxville McGhee Tyson

Thu 11/13

7:17 pm-11:30 am

1 stop17h 13m

$184

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 11/8

2:07 pm-4:53 pm

Nonstop1h 46m

Knoxville McGhee Tyson

Tue 11/11

7:59 am-9:05 am

Nonstop2h 06m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 10/29

9:43 am-12:31 pm

Nonstop1h 48m

Knoxville McGhee Tyson

Wed 11/5

6:16 pm-7:20 pm

Nonstop2h 04m

$190

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sun 10/12

8:00 pm-10:50 pm

Nonstop1h 50m

Knoxville McGhee Tyson

Sun 10/19

7:00 am-7:55 am

Nonstop1h 55m

$192

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 10/3

8:00 pm-10:50 pm

Nonstop1h 50m

Knoxville McGhee Tyson

Tue 10/7

7:00 am-7:55 am

Nonstop1h 55m

$194

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Sat 11/8

1:25 pm-9:13 pm

1 stop6h 48m

Knoxville McGhee Tyson

Fri 11/14

8:05 pm-12:01 am

1 stop4h 56m

$209

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Thu 10/2

9:25 am-4:55 pm

1 stop6h 30m

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-11:58 pm

1 stop4h 48m

$214

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Chicago, with most prices found around $244. If you aren’t able to travel during the month of January, then book flights to Knoxville from Chicago during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $244.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $266. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Knoxville for around $313.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago to Knoxville when you can find flight prices for as low as $267. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $293.

What is the cheapest Chicago to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $305 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago for as low as $222 on momondo.

What cabin class options are available on Chicago to Knoxville McGhee Tyson flights?

There are 4 cabin classes available to choose from on Chicago to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Chicago to Knoxville.

How have Chicago to Knoxville flight prices changed over time?

As of September 2025, prices for Chicago to Knoxville flights are approximately 9% more expensive when compared to flights at the same time last year.

When to book flights from Chicago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Knoxville (CHI to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Knoxville

Best Price Found

$52

Fastest flight time

1h 24m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago in the past 72 hours is $52. The best round-trip flight deal from Chicago to Knoxville found on momondo in the last 72 hours is $91.
The fastest flight from Chicago to Knoxville takes 1h 24m
Direct flights go from Chicago to Knoxville every day.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Chicago to Knoxville McGhee Tyson by plane?

    There are 454.2 mi between Chicago and Knoxville McGhee Tyson. 1h 24m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago to Knoxville?

  • What is the most popular airline from Chicago to Knoxville?

Best airlines flying from Chicago to Knoxville

Compare and see reviews for airlines that fly from Chicago to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $77Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $180Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $190Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
DeltaPriceFrom $193Free CancellationRating
7.9
7,957 reviews
Search Delta flights

  • United Airlines Flights From Chicago to Knoxville

    United Airlines flies from Chicago to Knoxville around 22 times per week, with 8,924 momondo users rating the airline 7.4/10. The cheapest United Airlines deal from Chicago to Knoxville in the last 72 hours was $190 (round-trip), much lower than the average airfare cost of $335 for United Airlines flights on this route.

  • Allegiant Air Flights From Chicago to Knoxville

    The best Allegiant Air deal for Chicago to Knoxville flight tickets found on momondo in the last 72 hours was $77, round-trip. It should be noted that an average Allegiant Air flight deal for this route in this time was higher, at $115 round-trip. Allegiant Air operates 1 flight out of Chicago into Knoxville in an average week, so prices vary by time and availability. 699 Allegiant Air reviews by users on momondo have scored the airline at 7.2/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Chicago with this policy.

How can momondo help me find flights from Chicago to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Chicago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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