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Cheap flights from Chicago to Knoxville from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Knoxville departing on 2/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Chicago to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
8:19 pm - 11:03 pm
ORD
-
TYS
1h 44mnonstop
United Airlines Logo
10:49 am - 11:53 am
TYS
-
ORD
2h 04mnonstop
$189United Airlines
Wed, Apr 15 - Tue, Apr 21
United Airlines Logo
2:06 pm - 4:52 pm
ORD
-
TYS
1h 46mnonstop
United Airlines Logo
7:00 am - 7:55 am
TYS
-
ORD
1h 55mnonstop
$198United Airlines
Fri, Apr 3 - Mon, Apr 6
United Airlines Logo
7:45 pm - 10:29 pm
ORD
-
TYS
1h 44mnonstop
United Airlines Logo
7:00 am - 7:55 am
TYS
-
ORD
1h 55mnonstop
$199United Airlines
Tue, Mar 31 - Sat, Apr 4
American Airlines Logo
8:02 am - 10:45 am
ORD
-
TYS
1h 43mnonstop
American Airlines Logo
7:51 am - 8:59 am
TYS
-
ORD
2h 08mnonstop
$204American Airlines
Wed, Feb 25 - Sat, Feb 28
Delta Logo
8:52 am - 4:42 pm
ORD
-
TYS
6h 50m
1 stop
Delta Logo
4:38 pm - 8:16 pm
TYS
-
ORD
4h 38m
1 stop
$209Delta
Wed, Apr 15 - Tue, Apr 21
Delta Logo
6:07 pm - 11:57 pm
MDW
-
TYS
4h 50m
1 stop
Delta Logo
5:40 am - 9:56 am
TYS
-
MDW
5h 16m
1 stop
$209Delta
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
7:25 am - 10:12 am
ORD
-
TYS
1h 47mnonstop
United Airlines Logo
1:53 pm - 2:55 pm
TYS
-
ORD
2h 02mnonstop
$213United Airlines
Wed, Feb 25 - Thu, Mar 5
Southwest Logo
3:35 pm - 8:05 pm
MDW
-
TYS
3h 30m
1 stop
Southwest Logo
12:30 pm - 7:55 pm
TYS
-
MDW
8h 25m
2 stops
$214Southwest
Tue, Mar 24 - Tue, Mar 31
Southwest Logo
10:30 am - 8:05 pm
MDW
-
TYS
8h 35m
2 stops
Southwest Logo
7:50 am - 4:25 pm
TYS
-
MDW
9h 35m
2 stops
$219Southwest
Tue, Mar 24 - Tue, Mar 31
Multiple Airlines Logo
6:05 am - 9:27 pm
MDW
-
TYS
14h 22m
2 stops
Multiple Airlines Logo
5:05 pm - 12:14 pm
TYS
-
MDW
20h 09m
1 stop
$251Multiple Airlines
Thu, Mar 12 - Mon, Mar 16

Southwest flights from Chicago to Knoxville

Our best Southwest deals on Chicago to Knoxville flight tickets
Southwest
Mar 24
MDW3:35 pmChicago Midway
3h 30m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
Mar 31
TYS12:30 pmKnoxville McGhee Tyson
8h 25m
2 stops
MDW7:55 pmChicago Midway
$214
Southwest
Mar 24
MDW10:30 amChicago Midway
8h 35m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
Mar 31
TYS7:50 amKnoxville McGhee Tyson
9h 35m
2 stops
MDW4:25 pmChicago Midway
$219
Southwest
Apr 7
ORD5:55 amChicago O'Hare Intl
10h 15m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
Apr 11
TYS6:40 amKnoxville McGhee Tyson
9h 50m
1 stop
ORD3:30 pmChicago O'Hare Intl
$220

American Airlines flights from Chicago to Knoxville

Our best American Airlines deals on Chicago to Knoxville flight tickets
American Airlines
Feb 25
ORD8:02 amChicago O'Hare Intl
1h 43m
TYS10:45 amKnoxville McGhee Tyson
Feb 28
TYS7:51 amKnoxville McGhee Tyson
2h 08m
ORD8:59 amChicago O'Hare Intl
$204
American Airlines
Apr 17
ORD5:24 pmChicago O'Hare Intl
1h 54m
TYS8:18 pmKnoxville McGhee Tyson
Apr 19
TYS8:48 pmKnoxville McGhee Tyson
2h 09m
ORD9:57 pmChicago O'Hare Intl
$233
American Airlines
Apr 17
ORD6:30 pmChicago O'Hare Intl
1h 51m
TYS9:21 pmKnoxville McGhee Tyson
Apr 19
TYS5:00 amKnoxville McGhee Tyson
6h 12m
1 stop
ORD10:12 amChicago O'Hare Intl
$243

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from Chicago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/15

8:19 pm-11:03 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Tue 4/21

10:49 am-11:53 am

Nonstop2h 04m

$189

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Fri 4/3

2:06 pm-4:52 pm

Nonstop1h 46m

Knoxville McGhee Tyson

Mon 4/6

7:00 am-7:55 am

Nonstop1h 55m

$198

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 3/31

7:45 pm-10:29 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Sat 4/4

7:00 am-7:55 am

Nonstop1h 55m

$199

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 2/25

8:02 am-10:45 am

Nonstop1h 43m

Knoxville McGhee Tyson

Sat 2/28

7:51 am-8:59 am

Nonstop2h 08m

$204

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/15

8:52 am-4:42 pm

1 stop6h 50m

Knoxville McGhee Tyson

Tue 4/21

4:38 pm-8:16 pm

1 stop4h 38m

$209

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 3/24

6:07 pm-11:57 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 3/31

5:40 am-9:56 am

1 stop5h 16m

$209

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 2/25

7:25 am-10:12 am

Nonstop1h 47m

Knoxville McGhee Tyson

Thu 3/5

1:53 pm-2:55 pm

Nonstop2h 02m

$213

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 3/24

3:35 pm-8:05 pm

1 stop3h 30m

Knoxville McGhee Tyson

Tue 3/31

12:30 pm-7:55 pm

2 stops8h 25m

$214

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Tue 3/24

10:30 am-8:05 pm

2 stops8h 35m

Knoxville McGhee Tyson

Tue 3/31

7:50 am-4:25 pm

2 stops9h 35m

$219

ChicagoKnoxville

MDW - TYS

MDWTYS

Chicago Midway

Thu 3/12

6:05 am-9:27 pm

2 stops14h 22m

Knoxville McGhee Tyson

Mon 3/16

5:05 pm-12:14 pm

1 stop20h 09m

$251

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Chicago, with most prices found around $232. If you aren’t able to travel during the month of September, then book flights to Knoxville from Chicago during June instead. Flights to Knoxville in June, while not as cheap as those in September, still average around $246.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $255. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Knoxville for around $327.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago to Knoxville when you can find flight prices for as low as $266. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $297.

What is the cheapest Chicago to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $316 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago for as low as $224 on momondo.

What cabin class options are available on Chicago to Knoxville McGhee Tyson flights?

There are 4 cabin classes available to choose from on Chicago to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Chicago to Knoxville.

How have Chicago to Knoxville flight prices changed over time?

As of February 2026, prices for Chicago to Knoxville flights are approximately 29% more expensive when compared to flights at the same time last year.

When to book flights from Chicago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Knoxville (CHI to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Knoxville

Best Price Found

$163

Fastest flight time

1h 26m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago in the past 72 hours is $163. The best round-trip flight deal from Chicago to Knoxville found on momondo in the last 72 hours is $230.
The fastest flight from Chicago to Knoxville takes 1h 26m
Direct flights go from Chicago to Knoxville every day.
There is 1 airport in Knoxville. From Chicago there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Chicago to Knoxville McGhee Tyson by plane?

    There are 454.2 mi between Chicago and Knoxville McGhee Tyson. 1h 26m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago to Knoxville?

  • What is the most popular airline from Chicago to Knoxville?

Best airlines flying from Chicago to Knoxville

Compare and see reviews for airlines that fly from Chicago to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
711 reviews
Search Allegiant Air flights
DeltaPriceFrom $138Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $188Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
9,259 reviews
Search United Airlines flights

  • United Airlines Flights From Chicago to Knoxville

    United Airlines flies from Chicago to Knoxville around 16 times per week, with 9,259 momondo users rating the airline 7.4/10. The cheapest United Airlines deal from Chicago to Knoxville in the last 72 hours was $189 (round-trip), much lower than the average airfare cost of $323 for United Airlines flights on this route.

  • American Airlines Flights From Chicago to Knoxville

    The best American Airlines deal for Chicago to Knoxville flight tickets found on momondo in the last 72 hours was $188, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $309 round-trip. American Airlines operates 7 flights out of Chicago into Knoxville in an average week, so prices vary by time and availability. 11,258 American Airlines reviews by users on momondo have scored the airline at 7.2/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Chicago with this policy.

How can momondo help me find flights from Chicago to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Chicago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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