Cheap flights from Chicago to Knoxville from $42

The month of June is, on average, the cheapest month to fly to Knoxville from Chicago, with most prices found around $257. If you aren’t able to travel during the month of June, then book flights to Knoxville from Chicago during January instead. Flights to Knoxville in January, while not as cheap as those in June, still average around $289.

The cheapest day to depart from Chicago to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $272. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Knoxville for around $408.

At noon is the cheapest time of day to fly from Chicago to Knoxville when you can find flight prices for as low as $242. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $347.

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $331 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago for as low as $195 on momondo.

There are 4 cabin classes available to choose from on Chicago to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Chicago to Knoxville.

As of September 2026, prices for Chicago to Knoxville flights are approximately 57% more expensive when compared to flights at the same time last year.

Allegiant Air and Southwest are the most popular carriers operating from Chicago to Knoxville McGhee Tyson

American Airlines, United Airlines and Allegiant Air are the top three most popular airlines that fly to Knoxville from Chicago according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 5 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

22 flights are operational daily from Chicago to Knoxville as of September 2026. The most popular departure time for this route is 4:00PM, with 41% of flights per day taking off in the afternoon.

The number of flights available between Chicago and Knoxville is 157 per week as of September 2026. The most frequent departure day is Thu, with 19% of weekly flights leaving on this day.