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Cheap flights from Chicago to Florence from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 10/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:00 am - 10:25 amORD-MSL
28h 25m1 stop
Multiple Airlines Logo
7:25 am - 5:12 pmMSL-ORD
9h 47m1 stop
$367Multiple Airlines
Find Deal
Sun, Oct 26 - Thu, Oct 30
Multiple Airlines Logo
8:14 am - 10:25 amORD-MSL
26h 11m2 stops
Multiple Airlines Logo
7:25 am - 5:12 pmMSL-ORD
9h 47m1 stop
$382Multiple Airlines
Find Deal
Sun, Oct 26 - Thu, Oct 30
Contour Logo
2:10 pm - 10:25 amORD-MSL
44h 15m2 stops
Contour Logo
2:15 pm - 6:45 pmMSL-ORD
28h 30m2 stops
$471Contour
Find Deal
Sun, Oct 26 - Thu, Oct 30
Multiple Airlines Logo
1:26 pm - 7:10 pmORD-MSL
29h 44m3 stops
Multiple Airlines Logo
7:25 am - 6:45 pmMSL-ORD
11h 20m2 stops
$546Multiple Airlines
Find Deal
Sun, Oct 26 - Thu, Oct 30
Multiple Airlines Logo
1:26 pm - 7:10 pmORD-MSL
29h 44m3 stops
Multiple Airlines Logo
2:15 pm - 4:23 pmMSL-ORD
26h 08m3 stops
$584Multiple Airlines
Find Deal
Sun, Oct 26 - Thu, Oct 30

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, Alabama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Chicago to Florence, Alabama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 10/26

6:00 am-10:25 am

1 stop28h 25m

Florence Muscle Shoals

Thu 10/30

7:25 am-5:12 pm

1 stop9h 47m

$367

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 10/26

8:14 am-10:25 am

2 stops26h 11m

Florence Muscle Shoals

Thu 10/30

7:25 am-5:12 pm

1 stop9h 47m

$382

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 10/26

2:10 pm-10:25 am

2 stops44h 15m

Florence Muscle Shoals

Thu 10/30

2:15 pm-6:45 pm

2 stops28h 30m

$471

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 10/26

1:26 pm-7:10 pm

3 stops29h 44m

Florence Muscle Shoals

Thu 10/30

7:25 am-6:45 pm

2 stops11h 20m

$546

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Sun 10/26

1:26 pm-7:10 pm

3 stops29h 44m

Florence Muscle Shoals

Thu 10/30

2:15 pm-4:23 pm

3 stops26h 08m

$584

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 10/31

11:53 am-7:10 pm

1 stop7h 17m

$129

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 10/31

2:10 pm-12:50 pm

2 stops46h 40m

$193

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 10/31

9:08 pm-12:50 pm

3 stops39h 42m

$238

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, Alabama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Chicago to Florence Muscle Shoals?

Contour is the most popular carrier operating from Chicago to Florence Muscle Shoals

What airlines fly to Florence, Alabama?

United Airlines, American Airlines and Denver Air Connection are the top three most popular airlines that fly to Florence, Alabama from Chicago according to our data. United Airlines is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Florence, Alabama. Keep in mind that there are 3 different airlines that fly to Florence, Alabama on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, Alabama

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, Alabama according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, Alabama (CHI to MSL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, Alabama

Direct flights

None
There are no direct flights from Chicago to Florence, Alabama. There are no popular flight routes from Chicago to Florence, Alabama.
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  • How far is Chicago to Florence Muscle Shoals by plane?

    There are 488.6 mi between Chicago and Florence Muscle Shoals. By plane, this route typically takes 26h 11m.

  • When did momondo last update prices for flights from Chicago to Florence Muscle Shoals Airport?

    Prices for flights from Chicago to Florence Muscle Shoals Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago to Florence Muscle Shoals Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago to Florence Muscle Shoals Airport.

  • What documentation or ID do you need to fly to Florence Muscle Shoals Airport?

    The required travel and health documents for your Florence Muscle Shoals Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Muscle Shoals Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Muscle Shoals
Sheffield

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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