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Cheap flights from Chicago to Florence from $382

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Florence departing on 4/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Contour Logo
11:20 am - 7:10 pm
ORD
-
MSL
7h 50m
2 stops
Contour Logo
1:00 pm - 4:15 pm
MSL
-
ORD
27h 15m
2 stops
$382Contour
Thu, Apr 2 - Mon, Apr 6
Multiple Airlines Logo
11:28 am - 7:10 pm
ORD
-
MSL
31h 42m
3 stops
Multiple Airlines Logo
7:25 am - 12:24 am
MSL
-
ORD
16h 59m
2 stops
$397Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
11:28 am - 7:10 pm
ORD
-
MSL
31h 42m
3 stops
Multiple Airlines Logo
7:25 am - 10:23 am
MSL
-
ORD
26h 58m
3 stops
$419Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
6:31 pm - 11:50 am
ORD
-
MSL
17h 19m
1 stop
Multiple Airlines Logo
1:00 pm - 5:15 pm
MSL
-
ORD
28h 15m
2 stops
$427Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Multiple Airlines Logo
4:36 pm - 11:50 am
ORD
-
MSL
19h 14m
2 stops
Multiple Airlines Logo
7:25 am - 11:17 am
MSL
-
ORD
27h 52m
2 stops
$428Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Multiple Airlines Logo
4:36 pm - 11:50 am
ORD
-
MSL
19h 14m
2 stops
Multiple Airlines Logo
7:25 am - 11:17 am
MSL
-
ORD
27h 52m
3 stops
$464Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Contour Logo
11:20 am - 7:10 pm
ORD
-
MSL
7h 50m
2 stops
Contour Logo
1:00 pm - 10:40 am
MSL
-
ORD
21h 40m
2 stops
$512Contour
Thu, Apr 2 - Sun, Apr 5
Multiple Airlines Logo
11:25 am - 11:50 am
ORD
-
MSL
24h 25m
3 stops
Multiple Airlines Logo
7:25 am - 11:17 am
MSL
-
ORD
27h 52m
3 stops
$532Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Contour Logo
11:20 am - 7:10 pm
ORD
-
MSL
7h 50m
2 stops
Contour Logo
1:00 pm - 4:15 pm
MSL
-
ORD
27h 15m
2 stops
$542Contour
Thu, Apr 2 - Mon, Apr 6
Contour Logo
11:20 am - 11:50 am
ORD
-
MSL
24h 30m
2 stops
Contour Logo
7:25 am - 10:40 am
MSL
-
ORD
27h 15m
2 stops
$577Contour
Thu, Apr 2 - Sun, Apr 5

momondo Fare Finder

 
Customize your flight search to find flights from Chicago to Florence, Alabama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Chicago to Florence, Alabama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Thu 4/2

11:20 am-7:10 pm

2 stops7h 50m

Florence Muscle Shoals

Mon 4/6

1:00 pm-4:15 pm

2 stops27h 15m

$382

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Wed 4/15

11:28 am-7:10 pm

3 stops31h 42m

Florence Muscle Shoals

Wed 4/22

7:25 am-12:24 am

2 stops16h 59m

$397

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Wed 4/15

11:28 am-7:10 pm

3 stops31h 42m

Florence Muscle Shoals

Wed 4/22

7:25 am-10:23 am

3 stops26h 58m

$419

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 4/3

6:31 pm-11:50 am

1 stop17h 19m

Florence Muscle Shoals

Tue 4/7

1:00 pm-5:15 pm

2 stops28h 15m

$427

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 4/3

4:36 pm-11:50 am

2 stops19h 14m

Florence Muscle Shoals

Tue 4/7

7:25 am-11:17 am

2 stops27h 52m

$428

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 4/3

4:36 pm-11:50 am

2 stops19h 14m

Florence Muscle Shoals

Tue 4/7

7:25 am-11:17 am

3 stops27h 52m

$464
Quickest round-trip

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Thu 4/2

11:20 am-7:10 pm

2 stops7h 50m

Florence Muscle Shoals

Sun 4/5

1:00 pm-10:40 am

2 stops21h 40m

$512

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Fri 4/3

11:25 am-11:50 am

3 stops24h 25m

Florence Muscle Shoals

Tue 4/7

7:25 am-11:17 am

3 stops27h 52m

$532

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Thu 4/2

11:20 am-7:10 pm

2 stops7h 50m

Florence Muscle Shoals

Mon 4/6

1:00 pm-4:15 pm

2 stops27h 15m

$542

ChicagoFlorence

ORD - MSL

ORDMSL

Chicago O'Hare Intl

Thu 4/2

11:20 am-11:50 am

2 stops24h 30m

Florence Muscle Shoals

Sun 4/5

7:25 am-10:40 am

2 stops27h 15m

$577

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Chicago to Florence, Alabama

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, Alabama?

United Airlines, American Airlines and Denver Air Connection are the top three most popular airlines that fly to Florence, Alabama from Chicago according to our data. United Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to Florence, Alabama. Keep in mind that there are 3 different airlines that fly to Florence, Alabama on a routine basis, so you have a few additional options to choose from.

When to book flights from Chicago to Florence, Alabama

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Florence, Alabama according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Florence, Alabama (CHI to MSL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Florence, Alabama

Fastest flight time

7h 50m

Direct flights

None
The fastest flight from Chicago to Florence, Alabama takes 7h 50m
There are no direct flights from Chicago to Florence, Alabama. There are no popular flight routes from Chicago to Florence, Alabama.
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  • How far is Chicago to Florence Muscle Shoals by plane?

    There are 488.6 mi between Chicago and Florence Muscle Shoals. By plane, this route typically takes 7h 50m.

  • When did momondo last update prices for flights from Chicago to Florence Muscle Shoals Airport?

    Prices for flights from Chicago to Florence Muscle Shoals Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Chicago to Florence Muscle Shoals Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago to Florence Muscle Shoals Airport.

  • What documentation or ID do you need to fly to Florence Muscle Shoals Airport?

    The required travel and health documents for your Florence Muscle Shoals Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Muscle Shoals Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Muscle Shoals
Sheffield

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Chicago to Florence.

I’m not ready to book a flight from Chicago to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Chicago are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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