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Cheap flights from Buffalo to Greenville from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Greenville departing on 12/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 11:59 amBUF-GSP
5h 59m1 stop
American Airlines Logo
7:39 pm - 11:44 pmGSP-BUF
4h 05m1 stop
$296American Airlines
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Tue, Dec 2 - Tue, Dec 9
Southwest Logo
3:40 pm - 7:40 pmBUF-GSP
4h 00m1 stop
Southwest Logo
4:45 pm - 10:00 pmGSP-BUF
5h 15m1 stop
$297Southwest
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
5:24 pm - 11:04 pmBUF-GSP
5h 40m2 stops
American Airlines Logo
6:53 pm - 10:57 pmGSP-BUF
4h 04m1 stop
$302American Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
5:30 am - 10:15 amBUF-GSP
4h 45m1 stop
American Airlines Logo
7:38 am - 12:33 pmGSP-BUF
4h 55m1 stop
$342American Airlines
Find Deal
Thu, Nov 27 - Fri, Nov 28
American Airlines Logo
5:30 am - 10:15 amBUF-GSP
4h 45m1 stop
American Airlines Logo
7:45 am - 3:00 pmGSP-BUF
7h 15m2 stops
$347American Airlines
Find Deal
Thu, Nov 27 - Fri, Nov 28
Southwest Logo
6:15 am - 4:05 pmBUF-GSP
9h 50m2 stops
Southwest Logo
7:40 am - 8:40 pmGSP-BUF
13h 00m2 stops
$348Southwest
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Wed, Dec 3 - Wed, Dec 10
United Airlines Logo
6:00 am - 11:19 amBUF-GSP
5h 19m1 stop
United Airlines Logo
12:19 pm - 11:34 pmGSP-BUF
11h 15m2 stops
$432United Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
Delta Logo
10:22 am - 2:44 pmBUF-GSP
4h 22m1 stop
Delta Logo
6:00 am - 11:00 amGSP-BUF
5h 00m1 stop
$434Delta
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Tue, Nov 18 - Sat, Nov 22
Delta Logo
6:25 pm - 11:45 pmBUF-GSP
5h 20m1 stop
Delta Logo
6:45 am - 11:00 amGSP-BUF
4h 15m1 stop
$444Delta
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Tue, Nov 11 - Thu, Nov 13
United Airlines Logo
10:37 am - 2:14 pmBUF-GSP
3h 37m1 stop
United Airlines Logo
6:25 am - 11:32 amGSP-BUF
5h 07m1 stop
$502United Airlines
Find Deal
Thu, Nov 27 - Sat, Nov 29

American Airlines flights from Buffalo to Greenville

Our best American Airlines deals on Buffalo to Greenville flight tickets
American Airlines
Dec 2
BUF6:00 amBuffalo
5h 59m
1 stop
GSP11:59 amGreenville
Dec 9
GSP7:39 pmGreenville
4h 05m
1 stop
BUF11:44 pmBuffalo
$296
Find similar
American Airlines
Dec 3
BUF5:24 pmBuffalo
5h 40m
2 stops
GSP11:04 pmGreenville
Dec 10
GSP6:53 pmGreenville
4h 04m
1 stop
BUF10:57 pmBuffalo
$302
Find similar
American Airlines
Nov 27
BUF5:30 amBuffalo
4h 45m
1 stop
GSP10:15 amGreenville
Nov 28
GSP7:38 amGreenville
4h 55m
1 stop
BUF12:33 pmBuffalo
$342
Find similar

Southwest flights from Buffalo to Greenville

Our best Southwest deals on Buffalo to Greenville flight tickets
Southwest
Dec 3
BUF3:40 pmBuffalo
4h 00m
1 stop
GSP7:40 pmGreenville
Dec 10
GSP4:45 pmGreenville
5h 15m
1 stop
BUF10:00 pmBuffalo
$297
Find similar
Southwest
Dec 3
BUF6:15 amBuffalo
9h 50m
2 stops
GSP4:05 pmGreenville
Dec 10
GSP7:40 amGreenville
13h 00m
2 stops
BUF8:40 pmBuffalo
$348
Find similar
Southwest
Nov 22
BUF6:10 pmBuffalo
4h 25m
1 stop
GSP10:35 pmGreenville
Nov 28
GSP8:00 amGreenville
4h 00m
1 stop
BUF12:00 pmBuffalo
$404
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Buffalo to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 12/2

6:00 am-11:59 am

1 stop5h 59m

Greenville

Tue 12/9

7:39 pm-11:44 pm

1 stop4h 05m

$296

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 12/3

3:40 pm-7:40 pm

1 stop4h 00m

Greenville

Wed 12/10

4:45 pm-10:00 pm

1 stop5h 15m

$297

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 12/3

5:24 pm-11:04 pm

2 stops5h 40m

Greenville

Wed 12/10

6:53 pm-10:57 pm

1 stop4h 04m

$302

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Thu 11/27

5:30 am-10:15 am

1 stop4h 45m

Greenville

Fri 11/28

7:38 am-12:33 pm

1 stop4h 55m

$342

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Thu 11/27

5:30 am-10:15 am

1 stop4h 45m

Greenville

Fri 11/28

7:45 am-3:00 pm

2 stops7h 15m

$347

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 12/3

6:15 am-4:05 pm

2 stops9h 50m

Greenville

Wed 12/10

7:40 am-8:40 pm

2 stops13h 00m

$348

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 12/2

6:00 am-11:19 am

1 stop5h 19m

Greenville

Tue 12/9

12:19 pm-11:34 pm

2 stops11h 15m

$432

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 11/18

10:22 am-2:44 pm

1 stop4h 22m

Greenville

Sat 11/22

6:00 am-11:00 am

1 stop5h 00m

$434

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Tue 11/11

6:25 pm-11:45 pm

1 stop5h 20m

Greenville

Thu 11/13

6:45 am-11:00 am

1 stop4h 15m

$444

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Thu 11/27

10:37 am-2:14 pm

1 stop3h 37m

Greenville

Sat 11/29

6:25 am-11:32 am

1 stop5h 07m

$502

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Buffalo to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Greenville?

What is the cheapest month to fly to Greenville?

The month of June is another great option to travel to Greenville, with average flight prices from Buffalo averaging around $311.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Buffalo. The lowest ticket price found for a Saturday departure recently was $365. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $539. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Buffalo to Greenville during this time can be as low as $282. Flights to Greenville are more costly in the morning, with an average ticket price of $396. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How have Buffalo to Greenville flight prices changed over time?

When to book flights from Buffalo to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Greenville (BUF to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Greenville

Direct flights

None
There are no direct flights from Buffalo to Greenville. There are no popular flight routes from Buffalo to Greenville.
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  • How far is Buffalo to Greenville by plane?

    A flight from Buffalo to Greenville will travel around 585.9 mi. A reasonable flight in good conditions will take 3h 37m.

  • When did momondo last update prices for flights from Buffalo Airport to Greenville Airport?

    Prices for flights from Buffalo Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Buffalo Airport to Greenville Airport?

  • How old do you have to be to fly from Buffalo Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Greenville?

Best airlines flying from Buffalo to Greenville

Compare and see reviews for airlines that fly from Buffalo to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,003 reviews
Search Delta flights
SouthwestPriceFrom $277Free CancellationRating
8.0
4,239 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Buffalo to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Buffalo to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Greenville?

Once all potential Buffalo to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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