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Cheap flights from Buffalo to Greenville from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Greenville departing on 1/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Buffalo to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 11:08 am
BUF
-
GSP
5h 08m1 stop
Delta Logo
11:35 am - 5:01 pm
GSP
-
BUF
5h 26m1 stop
$271Delta
Wed, Feb 25 - Tue, Mar 3
American Airlines Logo
3:53 pm - 11:08 pm
BUF
-
GSP
7h 15m2 stops
American Airlines Logo
10:30 am - 4:00 pm
GSP
-
BUF
5h 30m1 stop
$276American Airlines
Wed, Feb 25 - Tue, Mar 3
American Airlines Logo
11:27 am - 6:27 pm
BUF
-
GSP
7h 00m1 stop
American Airlines Logo
6:05 am - 10:57 am
GSP
-
BUF
4h 52m1 stop
$293American Airlines
Mon, Jan 12 - Mon, Jan 19
American Airlines Logo
3:53 pm - 11:08 pm
BUF
-
GSP
7h 15m2 stops
American Airlines Logo
5:29 pm - 11:27 pm
GSP
-
BUF
5h 58m2 stops
$295American Airlines
Wed, Feb 25 - Tue, Mar 3
American Airlines Logo
4:01 pm - 11:26 pm
BUF
-
GSP
7h 25m2 stops
American Airlines Logo
6:05 am - 10:57 am
GSP
-
BUF
4h 52m1 stop
$298American Airlines
Mon, Jan 12 - Mon, Jan 19
American Airlines Logo
6:53 pm - 11:26 pm
BUF
-
GSP
4h 33m1 stop
American Airlines Logo
6:00 am - 11:21 am
GSP
-
BUF
5h 21m1 stop
$303American Airlines
Mon, Jan 12 - Mon, Jan 19
American Airlines Logo
11:27 am - 10:19 pm
BUF
-
GSP
10h 52m1 stop
American Airlines Logo
6:00 am - 12:08 pm
GSP
-
BUF
6h 08m1 stop
$308American Airlines
Fri, Feb 6 - Tue, Feb 10
American Airlines Logo
4:17 pm - 10:19 pm
BUF
-
GSP
6h 02m1 stop
American Airlines Logo
6:23 pm - 10:55 pm
GSP
-
BUF
4h 32m1 stop
$311American Airlines
Fri, Jan 16 - Sun, Jan 18
American Airlines Logo
6:00 am - 6:27 pm
BUF
-
GSP
12h 27m1 stop
American Airlines Logo
8:09 am - 12:08 pm
GSP
-
BUF
3h 59m1 stop
$321American Airlines
Fri, Feb 6 - Tue, Feb 10
American Airlines Logo
4:01 pm - 11:26 pm
BUF
-
GSP
7h 25m2 stops
American Airlines Logo
6:00 am - 11:21 am
GSP
-
BUF
5h 21m1 stop
$324American Airlines
Fri, Feb 6 - Tue, Feb 10

Delta flights from Buffalo to Greenville

Our best Delta deals on Buffalo to Greenville flight tickets
Delta
Dec 25
BUF6:00 amBuffalo
5h 58m
1 stop
GSP11:58 amGreenville
Dec 25
GSP5:45 pmGreenville
5h 52m
1 stop
BUF11:37 pmBuffalo
$255
Find similar
Delta
Feb 25
BUF6:00 amBuffalo
5h 08m
1 stop
GSP11:08 amGreenville
Mar 3
GSP11:35 amGreenville
5h 26m
1 stop
BUF5:01 pmBuffalo
$271
Find similar
Delta
Dec 25
BUF6:00 amBuffalo
5h 58m
1 stop
GSP11:58 amGreenville
Dec 28
GSP6:23 pmGreenville
5h 05m
1 stop
BUF11:28 pmBuffalo
$416
Find similar

American Airlines flights from Buffalo to Greenville

Our best American Airlines deals on Buffalo to Greenville flight tickets
American Airlines
Feb 25
BUF3:53 pmBuffalo
7h 15m
2 stops
GSP11:08 pmGreenville
Mar 3
GSP10:30 amGreenville
5h 30m
1 stop
BUF4:00 pmBuffalo
$276
Find similar
American Airlines
Jan 12
BUF11:27 amBuffalo
7h 00m
1 stop
GSP6:27 pmGreenville
Jan 19
GSP6:05 amGreenville
4h 52m
1 stop
BUF10:57 amBuffalo
$293
Find similar
American Airlines
Feb 25
BUF3:53 pmBuffalo
7h 15m
2 stops
GSP11:08 pmGreenville
Mar 3
GSP5:29 pmGreenville
5h 58m
2 stops
BUF11:27 pmBuffalo
$295
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Buffalo to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 2/25

6:00 am-11:08 am

1 stop5h 08m

Greenville

Tue 3/3

11:35 am-5:01 pm

1 stop5h 26m

$271

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 2/25

3:53 pm-11:08 pm

2 stops7h 15m

Greenville

Tue 3/3

10:30 am-4:00 pm

1 stop5h 30m

$276

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 1/12

11:27 am-6:27 pm

1 stop7h 00m

Greenville

Mon 1/19

6:05 am-10:57 am

1 stop4h 52m

$293

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Wed 2/25

3:53 pm-11:08 pm

2 stops7h 15m

Greenville

Tue 3/3

5:29 pm-11:27 pm

2 stops5h 58m

$295

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 1/12

4:01 pm-11:26 pm

2 stops7h 25m

Greenville

Mon 1/19

6:05 am-10:57 am

1 stop4h 52m

$298

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Mon 1/12

6:53 pm-11:26 pm

1 stop4h 33m

Greenville

Mon 1/19

6:00 am-11:21 am

1 stop5h 21m

$303

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Fri 2/6

11:27 am-10:19 pm

1 stop10h 52m

Greenville

Tue 2/10

6:00 am-12:08 pm

1 stop6h 08m

$308

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Fri 1/16

4:17 pm-10:19 pm

1 stop6h 02m

Greenville

Sun 1/18

6:23 pm-10:55 pm

1 stop4h 32m

$311

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Fri 2/6

6:00 am-6:27 pm

1 stop12h 27m

Greenville

Tue 2/10

8:09 am-12:08 pm

1 stop3h 59m

$321

BuffaloGreenville

BUF - GSP

BUFGSP

Buffalo

Fri 2/6

4:01 pm-11:26 pm

2 stops7h 25m

Greenville

Tue 2/10

6:00 am-11:21 am

1 stop5h 21m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Buffalo to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of June is another great option to travel to Greenville, with average flight prices from Buffalo averaging around $311.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Buffalo. The lowest ticket price found for a Saturday departure recently was $365. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $539. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Buffalo to Greenville during this time can be as low as $282. Flights to Greenville are more costly in the morning, with an average ticket price of $396. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How have Buffalo to Greenville flight prices changed over time?

When to book flights from Buffalo to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Greenville (BUF to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Greenville

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Buffalo to Greenville takes 4h 28m
There are no direct flights from Buffalo to Greenville. There are no popular flight routes from Buffalo to Greenville.
Search flight deals

  • How far is Buffalo to Greenville by plane?

    A flight from Buffalo to Greenville will travel around 585.9 mi. A reasonable flight in good conditions will take 4h 28m.

  • When did momondo last update prices for flights from Buffalo Airport to Greenville Airport?

    Prices for flights from Buffalo Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Buffalo Airport to Greenville Airport?

  • How old do you have to be to fly from Buffalo Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Buffalo Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Buffalo to Greenville?

Best airlines flying from Buffalo to Greenville

Compare and see reviews for airlines that fly from Buffalo to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
8,005 reviews
Search Delta flights
SouthwestPriceFrom $277Free CancellationRating
7.9
4,250 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Buffalo to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Buffalo to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Greenville?

Once all potential Buffalo to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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