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Cheap flights from Buffalo to Florence from $473

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Florence departing on 3/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:40 pm - 11:57 pm
BUF
-
FLO
4h 17m
1 stop
American Airlines Logo
6:20 pm - 9:47 am
FLO
-
BUF
15h 27m
2 stops
$473American Airlines
Sun, Mar 15 - Mon, Mar 23
American Airlines Logo
1:57 pm - 11:57 pm
BUF
-
FLO
10h 00m
2 stops
American Airlines Logo
6:20 pm - 9:47 am
FLO
-
BUF
15h 27m
2 stops
$478American Airlines
Sun, Mar 15 - Mon, Mar 23
American Airlines Logo
1:32 pm - 5:50 pm
BUF
-
FLO
4h 18m
1 stop
American Airlines Logo
6:20 pm - 11:50 pm
FLO
-
BUF
5h 30m
1 stop
$501American Airlines
Sun, Mar 15 - Mon, Mar 23

American Airlines flights from Buffalo to Florence, South Carolina

Our best American Airlines deals on Buffalo to Florence, South Carolina flight tickets
American Airlines
Mar 15
BUF7:40 pmBuffalo
4h 17m
1 stop
FLO11:57 pmFlorence
Mar 23
FLO6:20 pmFlorence
15h 27m
2 stops
BUF9:47 amBuffalo
$473
American Airlines
Mar 15
BUF1:57 pmBuffalo
10h 00m
2 stops
FLO11:57 pmFlorence
Mar 23
FLO6:20 pmFlorence
15h 27m
2 stops
BUF9:47 amBuffalo
$478
American Airlines
Mar 15
BUF1:32 pmBuffalo
4h 18m
1 stop
FLO5:50 pmFlorence
Mar 23
FLO6:20 pmFlorence
5h 30m
1 stop
BUF11:50 pmBuffalo
$501

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from Buffalo to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Sun 3/15

7:40 pm-11:57 pm

1 stop4h 17m

Florence

Mon 3/23

6:20 pm-9:47 am

2 stops15h 27m

$473

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Sun 3/15

1:57 pm-11:57 pm

2 stops10h 00m

Florence

Mon 3/23

6:20 pm-9:47 am

2 stops15h 27m

$478

BuffaloFlorence

BUF - FLO

BUFFLO

Buffalo

Sun 3/15

1:32 pm-5:50 pm

1 stop4h 18m

Florence

Mon 3/23

6:20 pm-11:50 pm

1 stop5h 30m

$501

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Buffalo to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Buffalo according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Buffalo to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Florence, South Carolina (BUF to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Florence, South Carolina

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from Buffalo to Florence, South Carolina takes 4h 17m
There are no direct flights from Buffalo to Florence, South Carolina. There are no popular flight routes from Buffalo to Florence, South Carolina.
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  • How far is Buffalo to Florence by plane?

    Buffalo and Florence are 602.0 mi apart from one another. Flights usually cover this in 4h 17m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Buffalo Airport to Florence Airport?

    Prices for flights from Buffalo Airport to Florence Airport were last updated today.

  • How old do you have to be to fly from Buffalo Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Florence?

It is quick and easy to find Buffalo to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Buffalo to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Buffalo with this policy.

How can momondo help me find flights from Buffalo to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Buffalo.

I’m not ready to book a flight from Buffalo to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Buffalo to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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