Cheap flights from Knoxville (TYS) from $74

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Fly to

Route

Depart

Return

Price

Cheapest one-way

KnoxvilleHouston

TYS Knoxville McGhee Tyson - HOU Houston Hobby

TYSHOU

Knoxville McGhee Tyson

Fri 8/21

1:26 pm-2:46 pm

Nonstop2h 20m

$41

KnoxvilleDenver

TYS Knoxville McGhee Tyson - DEN Denver Intl

TYSDEN

Knoxville McGhee Tyson

Thu 11/12

6:30 am-7:40 am

Nonstop3h 10m

$46

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Fri 9/11

1:54 pm-8:31 pm

1 stop6h 37m

$79

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 11/10

1:00 pm-2:50 pm

Nonstop1h 50m

$87

Quickest one-way

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Wed 10/21

1:00 pm-2:45 pm

Nonstop1h 45m

$87

KnoxvilleChicago

TYS Knoxville McGhee Tyson - ORD Chicago O'Hare Intl

TYSORD

Knoxville McGhee Tyson

Thu 11/12

8:55 am-3:24 pm

1 stop7h 29m

$87

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Sat 9/26

7:15 pm-11:59 pm

1 stop4h 44m

$90

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 2/9

5:36 pm-11:59 pm

1 stop6h 23m

$90

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Sat 11/14

4:03 pm-8:40 pm

1 stop4h 37m

$96

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 10/13

6:23 pm-10:17 pm

1 stop3h 54m

$96

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 15 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$59

Flights from Knoxville to

Baltimore

from$92

Flights from Knoxville to

Boston

from$68

Flights from Knoxville to

Fort Lauderdale

from$53

Flights from Knoxville to

Jacksonville

from$29

Flights from Knoxville to

Key West

from$63

Flights from Knoxville to

Las Vegas

from$96

Flights from Knoxville to

Memphis

from$40

Flights from Knoxville to

Nashville

from$123

Flights from Knoxville to

New Haven

from$149

Flights from Knoxville to

Philadelphia

from$62

Flights from Knoxville to

Punta Gorda

from$56

Flights from Knoxville to

Sarasota

from$33

Flights from Knoxville to

Tampa

from$62

Flights from Knoxville to

Valparaiso, Florida

from$56

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

1:26 pm - 2:46 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

$41Allegiant Air

Fri, Aug 21

6:30 am - 7:40 amTYS Knoxville McGhee Tyson-DEN Denver Intl

3h 10mnonstop

$46Allegiant Air

Thu, Nov 12

1:54 pm - 8:31 pmTYS Knoxville McGhee Tyson-MCO Orlando

6h 37m1 stop Philadelphia

$79Multiple Airlines

Fri, Sep 11

1:00 pm - 2:50 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 50mnonstop

$87Southwest

Tue, Nov 10

1:00 pm - 2:45 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 45mnonstop

$87Southwest

Wed, Oct 21

8:55 am - 3:24 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

7h 29m1 stop Fort Lauderdale

$87Multiple Airlines

Thu, Nov 12

7:15 pm - 11:59 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 44m1 stop Miami

$90American Airlines

Sat, Sep 26

5:36 pm - 11:59 pmTYS Knoxville McGhee Tyson-MCO Orlando

6h 23m1 stop Miami

$90American Airlines

Tue, Feb 9

4:03 pm - 8:40 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 37m1 stop Atlanta Hartsfield-Jackson

$96Delta

Sat, Nov 14

6:23 pm - 10:17 pmTYS Knoxville McGhee Tyson-MCO Orlando

3h 54m1 stop Atlanta Hartsfield-Jackson

$96Delta

Tue, Oct 13

Last-minute flight deals from Knoxville

Enter your travel dates to find the best prices.

6:29 pm - 8:07 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 38mnonstop

5:23 pm - 7:05 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 42mnonstop

$97Allegiant Air

Mon, Aug 17 - Fri, Aug 21

3:49 pm - 5:51 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 02mnonstop

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$144Allegiant Air

Wed, Aug 19 - Wed, Aug 26

7:30 am - 1:22 pmTYS Knoxville McGhee Tyson-MCO Orlando

5h 52m1 stop Key West

5:23 pm - 7:05 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 42mnonstop

$186Multiple Airlines

Mon, Aug 17 - Fri, Aug 21

8:15 am - 1:34 pmTYS Knoxville McGhee Tyson-MCO Orlando

29h 19m2 stops Tampa St. Petersburg Huntsville

8:57 pm - 10:44 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 47mnonstop

$216Multiple Airlines

Sun, Aug 16 - Mon, Aug 17

6:12 pm - 11:57 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

6h 45m1 stop Atlanta Hartsfield-Jackson

11:22 am - 5:42 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

5h 20m1 stop Detroit Metropolitan Wayne County

$339Delta

Wed, Aug 19 - Mon, Aug 24

5:15 am - 10:06 amTYS Knoxville McGhee Tyson-MCO Orlando

4h 51m1 stop Charlotte Douglas

11:31 am - 6:53 pmMCO Orlando-TYS Knoxville McGhee Tyson

7h 22m1 stop Miami

$351American Airlines

Sat, Aug 15 - Mon, Aug 17

4:22 pm - 9:00 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 38m1 stop Charlotte Douglas

10:57 am - 5:34 pmMCO Orlando-TYS Knoxville McGhee Tyson

6h 37m1 stop Charlotte Douglas

$351American Airlines

Sat, Aug 15 - Mon, Aug 17

7:15 am - 1:08 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

6h 53m1 stop Detroit Metropolitan Wayne County

1:50 pm - 7:11 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

4h 21m1 stop Atlanta Hartsfield-Jackson

$369Delta

Wed, Aug 19 - Sat, Aug 22

1:00 pm - 4:59 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

4h 59m1 stop Washington, D.C. Dulles Intl

6:59 am - 9:57 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 58mnonstop

$374United Airlines

Wed, Aug 19 - Mon, Aug 24

1:53 pm - 2:54 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 01mnonstop

2:10 pm - 4:58 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 48mnonstop

$389United Airlines

Wed, Aug 19 - Mon, Aug 24

Cheapest international flights from Knoxville

Enter your travel dates to find the best prices.

7:04 pm - 3:18 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

20h 14m1 stop Fort Lauderdale

4:34 pm - 11:30 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

6h 56m1 stop Jacksonville

$238Multiple Airlines

Tue, Oct 13 - Sun, Oct 18

7:04 pm - 11:38 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

28h 34m1 stop Fort Lauderdale

5:12 pm - 10:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

16h 53m1 stop Fort Lauderdale

$241Multiple Airlines

Tue, Oct 13 - Tue, Oct 20

6:55 pm - 1:34 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

18h 39m1 stop Fort Lauderdale

7:50 am - 11:39 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

15h 49m1 stop Jacksonville

$260Multiple Airlines

Sat, Sep 26 - Thu, Oct 1

6:56 pm - 4:11 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

21h 15m1 stop Fort Lauderdale

6:35 am - 10:04 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

27h 29m1 stop Fort Lauderdale

$261Multiple Airlines

Sat, Aug 29 - Tue, Sep 1

4:41 pm - 1:31 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

20h 50m1 stop Fort Lauderdale

5:12 pm - 9:25 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

16h 13m1 stop Fort Lauderdale

$276Multiple Airlines

Sat, Oct 24 - Sat, Oct 31

3:57 pm - 12:38 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

7h 41m1 stop Fort Lauderdale

6:12 pm - 8:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

14h 53m1 stop Fort Lauderdale

$282Multiple Airlines

Sat, Nov 7 - Sat, Nov 14

1:54 pm - 12:01 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

10h 07m1 stop Philadelphia

7:50 am - 11:39 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

15h 49m1 stop Jacksonville

$283Multiple Airlines

Fri, Sep 25 - Thu, Oct 1

8:20 am - 5:43 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

9h 23m1 stop Orlando

6:55 pm - 7:34 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

24h 39m1 stop Philadelphia

$293Multiple Airlines

Fri, Sep 11 - Sun, Sep 20

5:40 pm - 3:17 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

21h 37m1 stop Fort Lauderdale

10:30 am - 8:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

21h 35m1 stop Fort Lauderdale

$294Multiple Airlines

Mon, Sep 28 - Sat, Oct 3

1:55 pm - 2:59 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

13h 04m1 stop Philadelphia

6:35 am - 10:04 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

27h 29m1 stop Fort Lauderdale

$298Multiple Airlines

Fri, Aug 28 - Tue, Sep 1

Cheapest domestic flights from Knoxville

Enter your travel dates to find the best prices.

1:26 pm - 2:46 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

3:36 pm - 6:43 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$74Allegiant Air

Fri, Aug 21 - Mon, Aug 24

1:26 pm - 2:46 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

3:36 pm - 6:43 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$80Allegiant Air

Fri, Aug 21 - Mon, Aug 24

10:54 am - 12:59 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

8:10 am - 10:14 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$84Allegiant Air

Thu, Sep 10 - Sat, Sep 12

10:54 am - 12:59 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

11:00 am - 1:04 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$85Allegiant Air

Thu, Sep 10 - Sat, Sep 12

1:26 pm - 2:46 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

3:36 pm - 6:43 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$87Allegiant Air

Fri, Aug 21 - Mon, Aug 24

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$90Allegiant Air

Sat, Sep 19 - Sun, Sep 27

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

8:10 am - 10:14 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$92Allegiant Air

Sat, Sep 5 - Sat, Sep 12

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

5:19 pm - 7:24 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$93Allegiant Air

Sat, Sep 19 - Mon, Oct 5

4:52 pm - 6:54 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 02mnonstop

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$97Allegiant Air

Thu, Aug 27 - Sun, Aug 30

6:29 pm - 8:07 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 38mnonstop

5:23 pm - 7:05 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 42mnonstop

$97Allegiant Air

Mon, Aug 17 - Fri, Aug 21

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

According to searches, the most popular destinations for domestic flights from Knoxville McGhee Tyson among momondo users are Orlando, Jacksonville, Washington, D.C., Fort Lauderdale and Chicago.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Jacksonville at $29. The next cheapest destinations are Gulf Shores, Sarasota, Memphis, Orlando and Washington, D.C..

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Allegiant Air, American Airlines, and Delta. For example, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport, start at $44, American Airlines flights from Knoxville to Washington, D.C. cost around $50, and Delta flights from Knoxville to Memphis are around $76.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $29 to Jacksonville. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $75 to travel from Knoxville to Jacksonville.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago and Chicago O'Hare Intl Airport are currently the destinations served most frequently from Knoxville, with 34, 25 and 25 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Charlotte, for which the starting price of a first class seat can be as low as $596.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of August 2026, there are 24 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.