Cheap flights from Knoxville (TYS) from $45

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Route

Depart

Return

Price

Cheapest one-way

Quickest one-way

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - SFB Orlando Sanford Intl

TYSSFB

Knoxville McGhee Tyson

Sat 11/14

4:55 pm-6:32 pm

Nonstop1h 37m

$45

KnoxvilleBoston

TYS Knoxville McGhee Tyson - BOS Boston Logan Intl

TYSBOS

Knoxville McGhee Tyson

Sat 11/7

6:00 am-8:19 am

Nonstop2h 19m

$47

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Mon 12/7

1:58 pm-12:14 am

2 stops34h 16m

$76

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Mon 12/7

1:58 pm-12:45 am

1 stop10h 47m

$77

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Sat 12/12

5:17 pm-9:14 pm

1 stop3h 57m

$93

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Wed 11/25

12:40 pm-2:25 pm

Nonstop1h 45m

$93

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Wed 12/9

1:00 pm-2:50 pm

Nonstop1h 50m

$93

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 11/3

7:14 pm-11:34 pm

1 stop4h 20m

$96

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 12/8

12:32 pm-4:40 pm

1 stop4h 08m

$102

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Mon 11/9

7:22 pm-12:40 am

1 stop5h 18m

$102

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 14 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$49

Flights from Knoxville to

Boston

from$60

Flights from Knoxville to

Denver

from$92

Flights from Knoxville to

Fort Lauderdale

from$61

Flights from Knoxville to

Jacksonville

from$41

Flights from Knoxville to

Key West

from$82

Flights from Knoxville to

Las Vegas

from$115

Flights from Knoxville to

Memphis

from$42

Flights from Knoxville to

New Haven

from$74

Flights from Knoxville to

Philadelphia

from$148

Flights from Knoxville to

Punta Gorda

from$99

Flights from Knoxville to

Sarasota

from$40

Flights from Knoxville to

Tampa

from$67

Flights from Knoxville to

Valparaiso, Florida

from$105

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

4:55 pm - 6:32 pmTYS Knoxville McGhee Tyson-SFB Orlando Sanford Intl

1h 37mnonstop

$45Allegiant Air

Sat, Nov 14

6:00 am - 8:19 amTYS Knoxville McGhee Tyson-BOS Boston Logan Intl

2h 19mnonstop

$47Allegiant Air

Sat, Nov 7

1:58 pm - 12:14 amTYS Knoxville McGhee Tyson-MCO Orlando

34h 16m2 stops Philadelphia Atlanta Hartsfield-Jackson

$76Multiple Airlines

Mon, Dec 7

1:58 pm - 12:45 amTYS Knoxville McGhee Tyson-MCO Orlando

10h 47m1 stop Philadelphia

$77Multiple Airlines

Mon, Dec 7

5:17 pm - 9:14 pmTYS Knoxville McGhee Tyson-MCO Orlando

3h 57m1 stop Charlotte Douglas

$93American Airlines

Sat, Dec 12

12:40 pm - 2:25 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 45mnonstop

$93Southwest

Wed, Nov 25

1:00 pm - 2:50 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 50mnonstop

$93Southwest

Wed, Dec 9

7:14 pm - 11:34 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 20m1 stop Charlotte Douglas

$96American Airlines

Tue, Nov 3

12:32 pm - 4:40 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 08m1 stop Atlanta Hartsfield-Jackson

$102Delta

Tue, Dec 8

7:22 pm - 12:40 amTYS Knoxville McGhee Tyson-MCO Orlando

5h 18m1 stop Atlanta Hartsfield-Jackson

$102Delta

Mon, Nov 9

Last-minute flight deals from Knoxville

Enter your travel dates to find the best prices.

4:14 pm - 6:15 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

8:00 am - 10:05 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$117Allegiant Air

Wed, Oct 14 - Wed, Oct 21

7:36 pm - 9:09 pmTYS Knoxville McGhee Tyson-SFB Orlando Sanford Intl

1h 33mnonstop

8:02 pm - 9:39 pmSFB Orlando Sanford Intl-TYS Knoxville McGhee Tyson

1h 37mnonstop

$123Allegiant Air

Thu, Oct 15 - Mon, Oct 19

4:14 pm - 6:15 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

5:36 pm - 11:29 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

17h 53m1 stop Washington, D.C. Dulles Intl

$155Multiple Airlines

Wed, Oct 14 - Wed, Oct 21

7:00 am - 8:41 amTYS Knoxville McGhee Tyson-MCO Orlando

1h 41mnonstop

8:56 am - 2:07 pmMCO Orlando-TYS Knoxville McGhee Tyson

5h 11m1 stop Key West

$202Multiple Airlines

Fri, Oct 16 - Mon, Oct 19

6:00 am - 6:56 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 56mnonstop

6:59 am - 9:45 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 46mnonstop

$359United Airlines

Wed, Oct 14 - Wed, Oct 21

7:45 pm - 12:23 amTYS Knoxville McGhee Tyson-MCO Orlando

4h 38m1 stop Atlanta Hartsfield-Jackson

5:30 am - 9:34 amMCO Orlando-TYS Knoxville McGhee Tyson

4h 04m1 stop Atlanta Hartsfield-Jackson

$360Delta

Thu, Oct 15 - Thu, Oct 29

10:48 am - 4:05 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

6h 17m1 stop Charlotte Douglas

9:05 pm - 11:59 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 54mnonstop

$369American Airlines

Wed, Oct 14 - Wed, Oct 21

2:38 pm - 8:38 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

7h 00m1 stop Atlanta Hartsfield-Jackson

5:27 am - 10:54 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

4h 27m1 stop Atlanta Hartsfield-Jackson

$379Delta

Wed, Oct 14 - Wed, Oct 21

8:30 am - 10:20 amTYS Knoxville McGhee Tyson-EWR Newark

1h 50mnonstop

6:00 am - 11:30 amEWR Newark-TYS Knoxville McGhee Tyson

5h 30m1 stop Washington, D.C. Dulles Intl

$384United Airlines

Fri, Oct 16 - Sun, Nov 15

11:35 am - 12:37 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 02mnonstop

8:20 am - 11:05 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 45mnonstop

$389American Airlines

Fri, Oct 16 - Sun, Oct 18

Cheapest international flights from Knoxville

Enter your travel dates to find the best prices.

7:45 am - 7:30 amTYS Knoxville McGhee Tyson-MAD Madrid Barajas

17h 45m1 stop Washington, D.C. Dulles Intl

12:40 pm - 7:33 pmMAD Madrid Barajas-TYS Knoxville McGhee Tyson

12h 53m1 stop Washington, D.C. Dulles Intl

$562Multiple Airlines

Thu, Nov 12 - Thu, Nov 19

2:14 pm - 9:45 amAVL Asheville Regional-MAD Madrid Barajas

13h 31m1 stop Atlanta Hartsfield-Jackson

12:20 pm - 10:43 pmMAD Madrid Barajas-AVL Asheville Regional

16h 23m1 stop Atlanta Hartsfield-Jackson

$734Delta

Sun, Nov 15 - Tue, Dec 15

10:23 am - 9:30 amAVL Asheville Regional-MAD Madrid Barajas

17h 07m1 stop Newark

6:05 am - 9:13 pmMAD Madrid Barajas-AVL Asheville Regional

21h 08m2 stops Frankfurt am Main Chicago O'Hare Intl

$735United Airlines

Sun, Feb 21 - Thu, Mar 4

5:38 pm - 5:35 pmCHA Chattanooga Lovell Field-CPH Kastrup Copenhagen

17h 57m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss

11:35 am - 5:03 pmCPH Kastrup Copenhagen-CHA Chattanooga Lovell Field

35h 28m2 stops Toronto Pearson Intl Chicago O'Hare Intl

$763United Airlines

Mon, Feb 1 - Fri, Feb 5

5:38 pm - 5:35 pmCHA Chattanooga Lovell Field-CPH Kastrup Copenhagen

17h 57m2 stops Chicago O'Hare Intl Munich Franz Josef Strauss

11:35 am - 5:03 pmCPH Kastrup Copenhagen-CHA Chattanooga Lovell Field

35h 28m2 stops Toronto Pearson Intl Chicago O'Hare Intl

$764United Airlines

Mon, Feb 1 - Fri, Feb 5

1:54 pm - 10:30 amTRI Blountville Tri Cities TN/VA-CPH Kastrup Copenhagen

14h 36m1 stop Atlanta Hartsfield-Jackson

1:50 pm - 10:28 pmCPH Kastrup Copenhagen-TRI Blountville Tri Cities TN/VA

14h 38m1 stop Atlanta Hartsfield-Jackson

$801Scandinavian Airlines

Fri, Nov 13 - Mon, Nov 16

6:15 am - 7:15 pmAVL Asheville Regional-HND Tokyo Haneda

23h 00m2 stops Chicago O'Hare Intl Seattle/Tacoma Intl

6:25 pm - 9:53 amHND Tokyo Haneda-AVL Asheville Regional

29h 28m2 stops San Francisco Chicago O'Hare Intl

$812United Airlines

Wed, Jan 13 - Fri, Jan 15

5:33 pm - 9:10 pmAVL Asheville Regional-HND Tokyo Haneda

37h 37m1 stop Chicago O'Hare Intl

7:40 pm - 9:53 amHND Tokyo Haneda-AVL Asheville Regional

28h 13m2 stops Los Angeles Chicago O'Hare Intl

$817United Airlines

Tue, Jan 12 - Fri, Jan 15

6:35 am - 6:25 pmAVL Asheville Regional-HND Tokyo Haneda

21h 50m1 stop Dallas/Fort Worth

8:25 pm - 9:52 pmHND Tokyo Haneda-AVL Asheville Regional

15h 27m1 stop Dallas/Fort Worth

$823American Airlines

Wed, Feb 10 - Thu, Feb 18

6:30 am - 6:10 pmCHA Chattanooga Lovell Field-IST Istanbul

27h 40m2 stops Chicago O'Hare Intl Frankfurt am Main

6:30 am - 10:45 pmIST Istanbul-CHA Chattanooga Lovell Field

24h 15m2 stops Frankfurt am Main Chicago O'Hare Intl

$832United Airlines

Mon, Feb 1 - Fri, Feb 5

Cheapest domestic flights from Knoxville

Enter your travel dates to find the best prices.

9:10 am - 11:05 amTYS Knoxville McGhee Tyson-EWR Newark

1h 55mnonstop

11:55 am - 1:58 pmEWR Newark-TYS Knoxville McGhee Tyson

2h 03mnonstop

$88Allegiant Air

Wed, Nov 4 - Wed, Nov 11

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

3:09 pm - 5:14 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$92Allegiant Air

Fri, Oct 23 - Tue, Oct 27

9:10 am - 11:05 amTYS Knoxville McGhee Tyson-EWR Newark

1h 55mnonstop

11:55 am - 1:58 pmEWR Newark-TYS Knoxville McGhee Tyson

2h 03mnonstop

$94Allegiant Air

Wed, Nov 4 - Wed, Nov 11

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

3:09 pm - 5:14 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$95Allegiant Air

Fri, Oct 23 - Tue, Oct 27

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

3:09 pm - 5:14 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$100Allegiant Air

Fri, Oct 23 - Tue, Oct 27

8:55 am - 11:00 amTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

3:13 pm - 5:18 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$103Allegiant Air

Thu, Nov 5 - Tue, Nov 10

8:55 am - 11:00 amTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

3:13 pm - 5:18 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$106Allegiant Air

Thu, Nov 5 - Tue, Nov 10

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

6:20 am - 8:25 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$109Allegiant Air

Fri, Oct 23 - Sun, Oct 25

4:14 pm - 6:15 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

8:00 am - 10:05 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$110Allegiant Air

Wed, Oct 28 - Wed, Nov 4

9:10 am - 11:05 amTYS Knoxville McGhee Tyson-EWR Newark

1h 55mnonstop

11:55 am - 1:58 pmEWR Newark-TYS Knoxville McGhee Tyson

2h 03mnonstop

$116Allegiant Air

Wed, Oct 21 - Wed, Oct 28

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Jacksonville, Sarasota, Orlando, Fort Lauderdale, and Washington, D.C. the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Sarasota at $40. The next cheapest destinations are Jacksonville, Memphis, Austin, Boston and Chicago.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Delta, Allegiant Air, and American Airlines. For example, Delta flights from Knoxville to Memphis, start at $42, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport cost around $46, and American Airlines flights from Knoxville to Washington, D.C. are around $54.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $40 to Sarasota. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $86 to travel from Knoxville to Sarasota.

Which destinations have the most frequent flights from Knoxville?

Chicago, Chicago O'Hare Intl Airport and Atlanta are currently the destinations served most frequently from Knoxville, with 24, 24 and 24 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, Delta and United Airlines frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to New York LaGuardia Airport, for which the starting price of a first class seat can be as low as $691.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of October 2026, there are 27 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.