Cheap flights from Knoxville (TYS) from $114

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Fly to

Route

Depart

Return

Price

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Mon 4/13

4:20 pm-5:52 pm

Nonstop3h 32m

$48

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Thu 4/23

4:28 pm-6:00 pm

Nonstop3h 32m

$49

KnoxvilleFort Lauderdale

TYS - FLL

TYSFLL

Knoxville McGhee Tyson

Mon 4/13

7:30 am-9:29 am

Nonstop1h 59m

$50

KnoxvilleFort Lauderdale

TYS - FLL

TYSFLL

Knoxville McGhee Tyson

Thu 3/12

9:43 pm-11:43 pm

Nonstop2h 00m

$53

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 4/14

7:05 am-12:50 pm

1 stop6h 45m

$81

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Tue 4/14

7:05 am-4:05 pm

2 stops10h 00m

$86

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Wed 3/25

5:40 am-10:51 am

1 stop8h 11m

$180

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Mon 5/4

5:56 pm-10:42 pm

1 stop7h 46m

$188

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Mon 3/23

6:21 pm-11:09 pm

1 stop7h 48m

$193

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Wed 5/27

5:57 pm-11:59 pm

1 stop9h 02m

$219

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 10 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Boston

from$62

Flights from Knoxville to

Denver

from$81

Flights from Knoxville to

Fort Lauderdale

from$60

Flights from Knoxville to

Jacksonville

from$47

Flights from Knoxville to

Key West

from$84

Flights from Knoxville to

Las Vegas

from$102

Flights from Knoxville to

Punta Gorda

from$118

Flights from Knoxville to

Sarasota

from$40

Flights from Knoxville to

Tampa

from$53

Flights from Knoxville to

Valparaiso, Florida

from$53

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

4:20 pm - 5:52 pm

TYS

DEN

3h 32mnonstop

$48Frontier

Mon, Apr 13

4:28 pm - 6:00 pm

TYS

DEN

3h 32mnonstop

$49Frontier

Thu, Apr 23

7:30 am - 9:29 am

TYS

FLL

1h 59mnonstop

$50Allegiant Air

Mon, Apr 13

9:43 pm - 11:43 pm

TYS

FLL

2h 00mnonstop

$53Allegiant Air

Thu, Mar 12

7:05 am - 12:50 pm

TYS

ORD

6h 45m

1 stop

$81Southwest

Tue, Apr 14

7:05 am - 4:05 pm

TYS

ORD

10h 00m

2 stops

$86Southwest

Tue, Apr 14

5:40 am - 10:51 am

TYS

SEA

8h 11m

1 stop

$180American Airlines

Wed, Mar 25

5:56 pm - 10:42 pm

TYS

SEA

7h 46m

1 stop

$188United Airlines

Mon, May 4

6:21 pm - 11:09 pm

TYS

SEA

7h 48m

1 stop

$193American Airlines

Mon, Mar 23

5:57 pm - 11:59 pm

TYS

SEA

9h 02m

1 stop

$219United Airlines

Wed, May 27

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

According to searches, the most popular destinations for domestic flights from Knoxville McGhee Tyson among momondo users are New York, Phoenix, Boston, Chicago and Washington, D.C..

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Sarasota at $40. The next cheapest destinations are Jacksonville, Valparaiso, Tampa, Washington, D.C. and Orlando.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Allegiant Air, American Airlines, and Delta. For example, Allegiant Air flights from Knoxville to South Bend, start at $31, American Airlines flights from Knoxville to Washington, D.C. cost around $38, and Delta flights from Knoxville to Valparaiso, Florida are around $67.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $40 to Sarasota. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $81 to travel from Knoxville to Sarasota.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago and Chicago O'Hare Intl Airport are currently the destinations served most frequently from Knoxville, with 38, 24 and 24 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Miami, for which the starting price of a first class seat can be as low as $500.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of February 2026, there are 23 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.