Cheap flights from Knoxville (TYS) from $108

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Fly to

Route

Depart

Return

Price

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 1/12

12:55 pm-2:43 pm

Nonstop1h 48m

$55

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 2/9

12:55 pm-2:43 pm

Nonstop1h 48m

$64

KnoxvilleNewark

TYS - EWR

TYSEWR

Knoxville McGhee Tyson

Mon 2/23

7:15 am-9:05 am

Nonstop1h 50m

$64

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 1/12

12:55 pm-2:43 pm

Nonstop1h 48m

$65

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-9:49 pm

Nonstop3h 31m

$74

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Sun 1/18

8:18 pm-9:49 pm

Nonstop3h 31m

$80

KnoxvilleDallas

TYS - DFW

TYSDFW

Knoxville McGhee Tyson

Wed 1/14

4:47 pm-11:35 pm

1 stop7h 48m

$89

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Sun 1/18

1:39 pm-7:03 pm

2 stops29h 24m

$92

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Thu 6/11

7:20 pm-11:45 pm

1 stop6h 25m

$125

KnoxvilleLos Angeles

TYS - LAX

TYSLAX

Knoxville McGhee Tyson

Tue 1/20

2:25 pm-9:41 pm

1 stop10h 16m

$139

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 10 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$66

Flights from Knoxville to

Boston

from$61

Flights from Knoxville to

Fort Lauderdale

from$53

Flights from Knoxville to

Jacksonville

from$44

Flights from Knoxville to

Key West

from$77

Flights from Knoxville to

Las Vegas

from$89

Flights from Knoxville to

Punta Gorda

from$67

Flights from Knoxville to

Sarasota

from$49

Flights from Knoxville to

Tampa

from$56

Flights from Knoxville to

Valparaiso, Florida

from$106

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

12:55 pm - 2:43 pm

TYS

MCO

1h 48mnonstop

$55Allegiant Air

Mon, Jan 12

12:55 pm - 2:43 pm

TYS

MCO

1h 48mnonstop

$64Allegiant Air

Mon, Feb 9

7:15 am - 9:05 am

TYS

EWR

1h 50mnonstop

$64Allegiant Air

Mon, Feb 23

12:55 pm - 2:43 pm

TYS

MCO

1h 48mnonstop

$65Allegiant Air

Mon, Jan 12

8:18 pm - 9:49 pm

TYS

DEN

3h 31mnonstop

$74Frontier

Thu, Jan 15

8:18 pm - 9:49 pm

TYS

DEN

3h 31mnonstop

$80Frontier

Sun, Jan 18

4:47 pm - 11:35 pm

TYS

DFW

7h 48m1 stop

$89Multiple Airlines

Wed, Jan 14

1:39 pm - 7:03 pm

TYS

MCO

29h 24m2 stops

$92Multiple Airlines

Sun, Jan 18

7:20 pm - 11:45 pm

TYS

DEN

6h 25m1 stop

$125Delta

Thu, Jun 11

2:25 pm - 9:41 pm

TYS

LAX

10h 16m1 stop

$139United Airlines

Tue, Jan 20

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Key West, New York, Phoenix, Chicago, and Washington, D.C. the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Houston at $39. The next cheapest destinations are Washington, D.C., Jacksonville, Sarasota, Fort Lauderdale and Denver.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by American Airlines, Allegiant Air, and Delta. For example, American Airlines flights from Knoxville to South Bend, start at $31, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport cost around $44, and Delta flights from Knoxville to Chicago Midway Airport are around $60.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $39 to Houston Hobby Airport. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $159 to travel from Knoxville to Houston Hobby Airport.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago and Chicago O'Hare Intl Airport are currently the destinations served most frequently from Knoxville, with 29, 24 and 24 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, Delta and United Airlines frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $489.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of December 2025, there are 24 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.