Cheap flights from Knoxville (TYS) from $52

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Route

Depart

Return

Price

Cheapest one-way

KnoxvilleDenver

TYS Knoxville McGhee Tyson - DEN Denver Intl

TYSDEN

Knoxville McGhee Tyson

Thu 11/12

6:30 am-7:40 am

Nonstop3h 10m

$52

KnoxvilleDenver

TYS Knoxville McGhee Tyson - DEN Denver Intl

TYSDEN

Knoxville McGhee Tyson

Thu 11/12

6:30 am-7:40 am

Nonstop3h 10m

$57

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Fri 10/16

3:54 pm-7:28 pm

2 stops27h 34m

$89

Quickest one-way

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 10/20

1:00 pm-2:45 pm

Nonstop1h 45m

$97

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 1/5

1:00 pm-2:50 pm

Nonstop1h 50m

$97

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Mon 11/2

2:12 pm-5:24 pm

2 stops27h 12m

$98

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Wed 10/7

4:49 pm-8:56 pm

1 stop4h 07m

$107

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 1/5

12:00 pm-6:36 pm

1 stop6h 36m

$107

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Tue 10/20

5:40 am-9:59 am

1 stop4h 19m

$107

KnoxvilleDallas

TYS Knoxville McGhee Tyson - DFW Dallas/Fort Worth

TYSDFW

Knoxville McGhee Tyson

Wed 11/11

7:30 pm-9:12 pm

Nonstop2h 42m

$127

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 13 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$46

Flights from Knoxville to

Boston

from$56

Flights from Knoxville to

Denver

from$71

Flights from Knoxville to

Fort Lauderdale

from$67

Flights from Knoxville to

Jacksonville

from$39

Flights from Knoxville to

Key West

from$92

Flights from Knoxville to

Las Vegas

from$78

Flights from Knoxville to

Miami

from$101

Flights from Knoxville to

Philadelphia

from$60

Flights from Knoxville to

Punta Gorda

from$52

Flights from Knoxville to

Sarasota

from$33

Flights from Knoxville to

Tampa

from$46

Flights from Knoxville to

Valparaiso, Florida

from$102

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

6:30 am - 7:40 amTYS Knoxville McGhee Tyson-DEN Denver Intl

3h 10mnonstop

$52Allegiant Air

Thu, Nov 12

6:30 am - 7:40 amTYS Knoxville McGhee Tyson-DEN Denver Intl

3h 10mnonstop

$57Allegiant Air

Thu, Nov 12

3:54 pm - 7:28 pmTYS Knoxville McGhee Tyson-MCO Orlando

27h 34m2 stops Philadelphia Atlanta Hartsfield-Jackson

$89Multiple Airlines

Fri, Oct 16

1:00 pm - 2:45 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 45mnonstop

$97Southwest

Tue, Oct 20

1:00 pm - 2:50 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 50mnonstop

$97Southwest

Tue, Jan 5

2:12 pm - 5:24 pmTYS Knoxville McGhee Tyson-MCO Orlando

27h 12m2 stops Philadelphia Atlanta Hartsfield-Jackson

$98Multiple Airlines

Mon, Nov 2

4:49 pm - 8:56 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 07m1 stop Charlotte Douglas

$107American Airlines

Wed, Oct 7

12:00 pm - 6:36 pmTYS Knoxville McGhee Tyson-MCO Orlando

6h 36m1 stop Atlanta Hartsfield-Jackson

$107Delta

Tue, Jan 5

5:40 am - 9:59 amTYS Knoxville McGhee Tyson-MCO Orlando

4h 19m1 stop Atlanta Hartsfield-Jackson

$107Delta

Tue, Oct 20

7:30 pm - 9:12 pmTYS Knoxville McGhee Tyson-DFW Dallas/Fort Worth

2h 42mnonstop

$127American Airlines

Wed, Nov 11

Last-minute flight deals from Knoxville

Enter your travel dates to find the best prices.

4:18 pm - 6:01 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 43mnonstop

12:59 pm - 2:42 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 43mnonstop

$113Allegiant Air

Mon, Sep 14 - Wed, Sep 30

4:18 pm - 6:01 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 43mnonstop

6:51 pm - 8:39 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 48mnonstop

$117Allegiant Air

Mon, Sep 14 - Mon, Sep 21

4:18 pm - 6:01 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 43mnonstop

5:19 pm - 11:39 pmMCO Orlando-TYS Knoxville McGhee Tyson

30h 20m2 stops Atlanta Hartsfield-Jackson Jacksonville

$160Multiple Airlines

Mon, Sep 14 - Wed, Sep 30

4:18 pm - 6:01 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 43mnonstop

9:53 pm - 11:39 pmMCO Orlando-TYS Knoxville McGhee Tyson

25h 46m3 stops Cleveland Hopkins Intl Atlanta Hartsfield-Jackson Jacksonville

$217Multiple Airlines

Mon, Sep 14 - Wed, Sep 30

8:15 pm - 9:30 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 15mnonstop

1:24 pm - 4:11 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 47mnonstop

$339American Airlines

Mon, Sep 14 - Sat, Sep 19

8:15 pm - 9:30 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 15mnonstop

1:19 pm - 9:06 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

6h 47m1 stop Charlotte Douglas

$349American Airlines

Mon, Sep 14 - Sat, Sep 19

12:45 pm - 2:35 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 50mnonstop

2:50 pm - 7:00 pmMCO Orlando-TYS Knoxville McGhee Tyson

4h 10m1 stop Nashville Intl

$392Southwest

Tue, Sep 15 - Tue, Sep 29

12:45 pm - 2:35 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 50mnonstop

11:25 am - 1:05 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 40mnonstop

$392Southwest

Tue, Sep 15 - Tue, Sep 29

7:15 am - 8:44 amTYS Knoxville McGhee Tyson-IAH Houston George Bush Intcntl

2h 29mnonstop

8:17 am - 11:34 amIAH Houston George Bush Intcntl-TYS Knoxville McGhee Tyson

2h 17mnonstop

$394United Airlines

Sun, Sep 13 - Sun, Sep 20

1:10 pm - 7:53 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

19h 43m2 stops Washington, D.C. Dulles Intl Dayton

10:30 am - 1:18 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 48mnonstop

$429United Airlines

Fri, Sep 11 - Sat, Sep 12

Cheapest international flights from Knoxville

Enter your travel dates to find the best prices.

6:15 am - 1:31 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

7h 16m1 stop Fort Lauderdale

12:59 am - 9:21 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

20h 22m1 stop Philadelphia

$271Multiple Airlines

Thu, Oct 15 - Sun, Oct 18

10:55 am - 1:25 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

25h 30m1 stop Fort Lauderdale

8:45 am - 10:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

26h 20m1 stop Fort Lauderdale

$281Multiple Airlines

Wed, Nov 4 - Tue, Nov 10

7:36 pm - 9:18 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

13h 42m1 stop Orlando Sanford Intl

12:59 am - 9:21 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

20h 22m1 stop Philadelphia

$282Multiple Airlines

Thu, Oct 15 - Sun, Oct 18

10:28 am - 5:43 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

7h 15m1 stop Orlando

4:34 pm - 11:30 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

6h 56m1 stop Jacksonville

$288Multiple Airlines

Wed, Oct 7 - Sun, Oct 11

10:28 am - 5:43 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

7h 15m1 stop Orlando

4:34 pm - 11:30 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

6h 56m1 stop Jacksonville

$294Multiple Airlines

Wed, Oct 7 - Sun, Oct 11

6:00 am - 3:38 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

9h 38m1 stop Miami

6:20 am - 10:59 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

16h 39m1 stop Miami

$310American Airlines

Thu, Oct 22 - Wed, Oct 28

7:30 pm - 9:38 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

13h 08m1 stop Miami

7:38 am - 8:15 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

13h 37m1 stop Miami

$315American Airlines

Wed, Jan 20 - Mon, Jan 25

7:58 pm - 12:09 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

16h 11m1 stop Charlotte Douglas

11:35 am - 11:59 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

13h 24m1 stop Miami

$316American Airlines

Mon, Oct 5 - Mon, Nov 2

7:58 pm - 12:09 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

16h 11m1 stop Charlotte Douglas

6:55 pm - 11:59 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

6h 04m1 stop Miami

$318American Airlines

Mon, Oct 5 - Mon, Nov 2

6:00 am - 1:28 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

7h 28m1 stop Miami

7:30 am - 8:17 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

13h 47m1 stop Miami

$321American Airlines

Wed, Oct 14 - Mon, Nov 9

Cheapest domestic flights from Knoxville

Enter your travel dates to find the best prices.

1:31 pm - 2:51 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

4:27 pm - 7:34 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$98Allegiant Air

Fri, Sep 25 - Mon, Sep 28

12:49 pm - 2:09 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

5:09 pm - 8:16 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$99Allegiant Air

Fri, Nov 6 - Mon, Nov 9

8:10 am - 10:05 amTYS Knoxville McGhee Tyson-EWR Newark

1h 55mnonstop

11:55 am - 1:58 pmEWR Newark-TYS Knoxville McGhee Tyson

2h 03mnonstop

$105Allegiant Air

Wed, Oct 14 - Wed, Oct 21

2:54 pm - 4:11 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 17mnonstop

3:51 pm - 6:55 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 04mnonstop

$106Allegiant Air

Fri, Oct 23 - Mon, Oct 26

8:10 am - 10:05 amTYS Knoxville McGhee Tyson-EWR Newark

1h 55mnonstop

11:55 am - 1:58 pmEWR Newark-TYS Knoxville McGhee Tyson

2h 03mnonstop

$106Allegiant Air

Wed, Oct 14 - Wed, Oct 21

1:31 pm - 2:51 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

4:27 pm - 7:34 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$110Allegiant Air

Fri, Sep 25 - Mon, Sep 28

1:31 pm - 2:51 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 20mnonstop

4:27 pm - 7:34 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 07mnonstop

$117Allegiant Air

Fri, Sep 25 - Mon, Sep 28

2:54 pm - 4:11 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 17mnonstop

3:51 pm - 6:55 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 04mnonstop

$119Allegiant Air

Fri, Oct 23 - Mon, Oct 26

7:00 am - 8:41 amTYS Knoxville McGhee Tyson-MCO Orlando

1h 41mnonstop

9:31 am - 11:14 amMCO Orlando-TYS Knoxville McGhee Tyson

1h 43mnonstop

$123Allegiant Air

Fri, Oct 16 - Mon, Oct 19

8:25 am - 10:11 amTYS Knoxville McGhee Tyson-MCO Orlando

1h 46mnonstop

11:43 am - 1:31 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 48mnonstop

$124Allegiant Air

Fri, Nov 13 - Mon, Nov 16

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Jacksonville, Phoenix, Key West, Washington, D.C., and New York the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Sarasota at $33. The next cheapest destinations are Jacksonville, Orlando, Tampa, Austin and Houston.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Delta, Allegiant Air, and American Airlines. For example, Delta flights from Knoxville to Memphis, start at $41, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport cost around $46, and American Airlines flights from Knoxville to Washington, D.C. are around $50.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $33 to Sarasota. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $64 to travel from Knoxville to Sarasota.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Washington, D.C. and Washington, D.C. Dulles Intl Airport are currently the destinations served most frequently from Knoxville, with 26, 18 and 17 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $437.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of September 2026, there are 24 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.