Cheap flights from Knoxville (TYS) from $55

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Fly to

Route

Depart

Return

Price

Cheapest one-way

Quickest one-way

KnoxvilleWashington, D.C.

TYS - IAD

TYSIAD

Knoxville McGhee Tyson

Fri 7/17

12:53 pm-2:26 pm

Nonstop1h 33m

$39

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-8:58 pm

Nonstop1h 38m

$40

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Fri 7/31

7:20 pm-8:58 pm

Nonstop1h 38m

$41

KnoxvilleWashington, D.C.

TYS - IAD

TYSIAD

Knoxville McGhee Tyson

Thu 7/30

9:11 pm-7:38 pm

1 stop22h 27m

$108

KnoxvilleWashington, D.C.

TYS - IAD

TYSIAD

Knoxville McGhee Tyson

Mon 8/17

6:29 pm-10:07 am

1 stop15h 38m

$109

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 7/10

8:19 pm-8:52 pm

1 stop25h 33m

$124

KnoxvilleHouston

TYS - IAH

TYSIAH

Knoxville McGhee Tyson

Mon 7/20

8:19 pm-12:40 am

1 stop29h 21m

$129

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

Fri 7/31

6:40 am-10:05 am

1 stop4h 25m

$145

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

Thu 8/27

7:10 am-3:05 pm

2 stops8h 55m

$150

KnoxvilleLas Vegas

TYS - LAS

TYSLAS

Knoxville McGhee Tyson

Tue 8/25

7:15 am-1:15 pm

1 stop9h 00m

$156

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 16 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Atlanta

from$153

Flights from Knoxville to

Austin

from$43

Flights from Knoxville to

Baltimore

from$145

Flights from Knoxville to

Boston

from$68

Flights from Knoxville to

Denver

from$106

Flights from Knoxville to

Fort Lauderdale

from$59

Flights from Knoxville to

Jacksonville

from$39

Flights from Knoxville to

Key West

from$79

Flights from Knoxville to

Las Vegas

from$106

Flights from Knoxville to

Nashville

from$139

Flights from Knoxville to

Philadelphia

from$39

Flights from Knoxville to

Punta Gorda

from$60

Flights from Knoxville to

Sarasota

from$65

Flights from Knoxville to

Tampa

from$48

Flights from Knoxville to

Tampa

from$257

Flights from Knoxville to

Valparaiso, Florida

from$40

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

12:53 pm - 2:26 pm

TYS

IAD

1h 33mnonstop

$39Allegiant Air

Fri, Jul 17

7:20 pm - 8:58 pm

TYS

MCO

1h 38mnonstop

$40Allegiant Air

Mon, Aug 3

7:20 pm - 8:58 pm

TYS

MCO

1h 38mnonstop

$41Allegiant Air

Fri, Jul 31

9:11 pm - 7:38 pm

TYS

IAD

22h 27m

1 stop

$108Multiple Airlines

Thu, Jul 30

6:29 pm - 10:07 am

TYS

IAD

15h 38m

1 stop

$109Multiple Airlines

Mon, Aug 17

8:19 pm - 8:52 pm

TYS

ORD

25h 33m

1 stop

$124Frontier

Fri, Jul 10

8:19 pm - 12:40 am

TYS

IAH

29h 21m

1 stop

$129Frontier

Mon, Jul 20

6:40 am - 10:05 am

TYS

HOU

4h 25m

1 stop

$145Southwest

Fri, Jul 31

7:10 am - 3:05 pm

TYS

HOU

8h 55m

2 stops

$150Southwest

Thu, Aug 27

7:15 am - 1:15 pm

TYS

LAS

9h 00m

1 stop

$156United Airlines

Tue, Aug 25

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

According to searches, the most popular destinations for domestic flights from Knoxville McGhee Tyson among momondo users are Orlando, Jacksonville, Sarasota, Fort Lauderdale and Chicago.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Washington, D.C. at $38. The next cheapest destinations are Jacksonville, Philadelphia, Valparaiso, Austin and Tampa.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Allegiant Air, American Airlines, and Delta. For example, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport, start at $44, American Airlines flights from Knoxville to Washington, D.C. cost around $50, and Delta flights from Knoxville to Valparaiso, Florida are around $76.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $38 to Washington, D.C. Dulles Intl Airport. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $1,956 to travel from Knoxville to Washington, D.C. Dulles Intl Airport.

Which destinations have the most frequent flights from Knoxville?

Chicago, Chicago O'Hare Intl Airport and Washington, D.C. are currently the destinations served most frequently from Knoxville, with 34, 33 and 22 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $582.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of July 2026, there are 25 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.