Cheap flights from Knoxville (TYS) from $92

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Fly to

Route

Depart

Return

Price

Cheapest one-way

Quickest one-way

KnoxvilleOrlando

TYS - SFB

TYSSFB

Knoxville McGhee Tyson

Wed 7/1

5:18 pm-6:53 pm

Nonstop1h 35m

$44

KnoxvilleOrlando

TYS - SFB

TYSSFB

Knoxville McGhee Tyson

Sat 7/4

6:00 am-7:35 am

Nonstop1h 35m

$47

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

Sun 9/6

7:00 am-8:05 am

Nonstop3h 05m

$48

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

Fri 8/21

1:26 pm-2:46 pm

Nonstop2h 20m

$48

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Wed 8/12

8:19 pm-8:52 pm

1 stop25h 33m

$118

KnoxvilleLos Angeles

TYS - LAX

TYSLAX

Knoxville McGhee Tyson

Wed 8/12

8:19 pm-12:11 am

1 stop6h 52m

$120

KnoxvilleDallas

TYS - DFW

TYSDFW

Knoxville McGhee Tyson

Tue 7/28

5:40 am-8:54 am

1 stop4h 14m

$132

KnoxvilleLos Angeles

TYS - LAX

TYSLAX

Knoxville McGhee Tyson

Tue 6/30

5:37 am-12:01 pm

1 stop9h 24m

$180

KnoxvilleLos Angeles

TYS - LAX

TYSLAX

Knoxville McGhee Tyson

Sat 7/4

2:30 pm-7:20 pm

2 stops7h 50m

$185

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Tue 7/28

3:59 pm-10:33 pm

1 stop9h 34m

$195

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 13 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$49

Flights from Knoxville to

Baltimore

from$106

Flights from Knoxville to

Boston

from$71

Flights from Knoxville to

Denver

from$114

Flights from Knoxville to

Fort Lauderdale

from$65

Flights from Knoxville to

Jacksonville

from$47

Flights from Knoxville to

Key West

from$61

Flights from Knoxville to

Las Vegas

from$124

Flights from Knoxville to

Philadelphia

from$44

Flights from Knoxville to

Punta Gorda

from$132

Flights from Knoxville to

Sarasota

from$59

Flights from Knoxville to

Tampa

from$50

Flights from Knoxville to

Valparaiso, Florida

from$59

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

5:18 pm - 6:53 pm

TYS

SFB

1h 35mnonstop

$44Allegiant Air

Wed, Jul 1

6:00 am - 7:35 am

TYS

SFB

1h 35mnonstop

$47Allegiant Air

Sat, Jul 4

7:00 am - 8:05 am

TYS

DEN

3h 05mnonstop

$48Allegiant Air

Sun, Sep 6

1:26 pm - 2:46 pm

TYS

HOU

2h 20mnonstop

$48Allegiant Air

Fri, Aug 21

8:19 pm - 8:52 pm

TYS

ORD

25h 33m

1 stop

$118Frontier

Wed, Aug 12

8:19 pm - 12:11 am

TYS

LAX

6h 52m

1 stop

$120Frontier

Wed, Aug 12

5:40 am - 8:54 am

TYS

DFW

4h 14m

1 stop

$132Delta

Tue, Jul 28

5:37 am - 12:01 pm

TYS

LAX

9h 24m

1 stop

$180American Airlines

Tue, Jun 30

2:30 pm - 7:20 pm

TYS

LAX

7h 50m

2 stops

$185Southwest

Sat, Jul 4

3:59 pm - 10:33 pm

TYS

SEA

9h 34m

1 stop

$195Delta

Tue, Jul 28

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Jacksonville, Orlando, Fort Lauderdale, Washington, D.C., and Chicago the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Houston at $24. The next cheapest destinations are Orlando, Washington, D.C., Philadelphia, Jacksonville and Austin.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Allegiant Air, American Airlines, and Delta. For example, Allegiant Air flights from Knoxville to South Bend, start at $31, American Airlines flights from Knoxville to Washington, D.C. cost around $50, and Delta flights from Knoxville to Valparaiso, Florida are around $68.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $24 to Houston Hobby Airport. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $120 to travel from Knoxville to Houston Hobby Airport.

Which destinations have the most frequent flights from Knoxville?

Chicago, Chicago O'Hare Intl Airport and Washington, D.C. are currently the destinations served most frequently from Knoxville, with 31, 31 and 24 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Dallas/Fort Worth Airport, for which the starting price of a first class seat can be as low as $836.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of June 2026, there are 24 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.