Cheap flights from Knoxville (TYS) from $123

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Fly to

Route

Depart

Return

Price

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 3/2

2:06 pm-3:50 pm

Nonstop1h 44m

$48

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 2/23

2:06 pm-3:51 pm

Nonstop1h 45m

$53

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Wed 4/1

8:30 am-10:06 am

Nonstop1h 36m

$54

KnoxvilleOrlando

TYS - MCO

TYSMCO

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-5:33 am

1 stop9h 20m

$74

KnoxvilleHouston

TYS - IAH

TYSIAH

Knoxville McGhee Tyson

Mon 2/23

8:13 pm-7:14 pm

1 stop24h 01m

$86

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Sat 4/11

5:44 am-10:51 am

1 stop8h 07m

$193

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

Sun 2/15

5:40 am-11:48 am

1 stop7h 08m

$194

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Tue 3/3

6:45 am-1:49 pm

2 stops10h 04m

$224

KnoxvilleSeattle

TYS - SEA

TYSSEA

Knoxville McGhee Tyson

Sat 2/21

2:21 pm-8:56 pm

1 stop9h 35m

$258

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

Sat 2/14

5:00 pm-10:28 pm

1 stop6h 28m

$319

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 10 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Boston

from$50

Flights from Knoxville to

Denver

from$78

Flights from Knoxville to

Fort Lauderdale

from$53

Flights from Knoxville to

Jacksonville

from$53

Flights from Knoxville to

Key West

from$88

Flights from Knoxville to

Las Vegas

from$163

Flights from Knoxville to

Punta Gorda

from$59

Flights from Knoxville to

Sarasota

from$80

Flights from Knoxville to

Tampa

from$53

Flights from Knoxville to

Valparaiso, Florida

from$53

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

2:06 pm - 3:50 pm

TYS

MCO

1h 44mnonstop

$48Allegiant Air

Mon, Mar 2

2:06 pm - 3:51 pm

TYS

MCO

1h 45mnonstop

$53Allegiant Air

Mon, Feb 23

8:30 am - 10:06 am

TYS

MCO

1h 36mnonstop

$54Allegiant Air

Wed, Apr 1

8:13 pm - 5:33 am

TYS

MCO

9h 20m

1 stop

$74Frontier

Mon, Feb 23

8:13 pm - 7:14 pm

TYS

IAH

24h 01m

1 stop

$86Frontier

Mon, Feb 23

5:44 am - 10:51 am

TYS

SEA

8h 07m

1 stop

$193American Airlines

Sat, Apr 11

5:40 am - 11:48 am

TYS

HOU

7h 08m

1 stop

$194American Airlines

Sun, Feb 15

6:45 am - 1:49 pm

TYS

SEA

10h 04m

2 stops

$224United Airlines

Tue, Mar 3

2:21 pm - 8:56 pm

TYS

SEA

9h 35m

1 stop

$258United Airlines

Sat, Feb 21

5:00 pm - 10:28 pm

TYS

HOU

6h 28m

1 stop

$319Delta

Sat, Feb 14

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Jacksonville, New York, Phoenix, Chicago, and Washington, D.C. the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Washington, D.C. at $42. The next cheapest destinations are Boston, Jacksonville, Valparaiso, Tampa and Fort Lauderdale.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Allegiant Air, American Airlines, and Delta. For example, Allegiant Air flights from Knoxville to South Bend, start at $31, American Airlines flights from Knoxville to Washington, D.C. cost around $38, and Delta flights from Knoxville to Chicago Midway Airport are around $60.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $42 to Washington, D.C. Dulles Intl Airport. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $789 to travel from Knoxville to Washington, D.C. Dulles Intl Airport.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago and Chicago O'Hare Intl Airport are currently the destinations served most frequently from Knoxville, with 36, 21 and 21 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, Delta and United Airlines frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Washington, D.C. Reagan-National Airport, for which the starting price of a first class seat can be as low as $400.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of February 2026, there are 23 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.