Cheap flights from Knoxville (TYS) from $45

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Fly to

Route

Depart

Return

Price

Cheapest one-way

Quickest one-way

KnoxvilleFort Lauderdale

TYS Knoxville McGhee Tyson - FLL Fort Lauderdale

TYSFLL

Knoxville McGhee Tyson

Fri 10/23

9:28 pm-11:29 pm

Nonstop2h 01m

$45

KnoxvilleDenver

TYS Knoxville McGhee Tyson - DEN Denver Intl

TYSDEN

Knoxville McGhee Tyson

Thu 11/12

6:30 am-7:40 am

Nonstop3h 10m

$50

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Fri 10/23

12:57 pm-5:21 pm

2 stops28h 24m

$80

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Fri 10/23

12:57 pm-9:30 pm

2 stops32h 33m

$86

KnoxvilleHouston

TYS Knoxville McGhee Tyson - HOU Houston Hobby

TYSHOU

Knoxville McGhee Tyson

Wed 9/16

3:00 pm-11:15 pm

1 stop9h 15m

$89

KnoxvilleHouston

TYS Knoxville McGhee Tyson - HOU Houston Hobby

TYSHOU

Knoxville McGhee Tyson

Wed 9/16

7:00 am-1:45 pm

2 stops7h 45m

$94

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Sat 10/10

7:58 pm-12:32 am

1 stop4h 34m

$101

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Sat 10/3

7:15 pm-11:59 pm

1 stop4h 44m

$102

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Thu 9/17

5:40 am-8:57 am

1 stop3h 17m

$102

KnoxvilleOrlando

TYS Knoxville McGhee Tyson - MCO Orlando

TYSMCO

Knoxville McGhee Tyson

Mon 10/12

7:45 pm-12:23 am

1 stop4h 38m

$102

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 13 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$46

Flights from Knoxville to

Boston

from$62

Flights from Knoxville to

Denver

from$74

Flights from Knoxville to

Fort Lauderdale

from$58

Flights from Knoxville to

Jacksonville

from$39

Flights from Knoxville to

Key West

from$63

Flights from Knoxville to

Las Vegas

from$78

Flights from Knoxville to

Miami

from$101

Flights from Knoxville to

Philadelphia

from$60

Flights from Knoxville to

Punta Gorda

from$52

Flights from Knoxville to

Sarasota

from$33

Flights from Knoxville to

Tampa

from$46

Flights from Knoxville to

Valparaiso, Florida

from$102

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

$45Allegiant Air

Fri, Oct 23

6:30 am - 7:40 amTYS Knoxville McGhee Tyson-DEN Denver Intl

3h 10mnonstop

$50Allegiant Air

Thu, Nov 12

12:57 pm - 5:21 pmTYS Knoxville McGhee Tyson-MCO Orlando

28h 24m2 stops Philadelphia Atlanta Hartsfield-Jackson

$80Multiple Airlines

Fri, Oct 23

12:57 pm - 9:30 pmTYS Knoxville McGhee Tyson-MCO Orlando

32h 33m2 stops Philadelphia Atlanta Hartsfield-Jackson

$86Multiple Airlines

Fri, Oct 23

3:00 pm - 11:15 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

9h 15m1 stop Denver Intl

$89Southwest

Wed, Sep 16

7:00 am - 1:45 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

7h 45m2 stops Nashville Intl Birmingham

$94Southwest

Wed, Sep 16

7:58 pm - 12:32 amTYS Knoxville McGhee Tyson-MCO Orlando

4h 34m1 stop Charlotte Douglas

$101American Airlines

Sat, Oct 10

7:15 pm - 11:59 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 44m1 stop Miami

$102American Airlines

Sat, Oct 3

5:40 am - 8:57 amTYS Knoxville McGhee Tyson-MCO Orlando

3h 17m1 stop Atlanta Hartsfield-Jackson

$102Delta

Thu, Sep 17

7:45 pm - 12:23 amTYS Knoxville McGhee Tyson-MCO Orlando

4h 38m1 stop Atlanta Hartsfield-Jackson

$102Delta

Mon, Oct 12

Last-minute flight deals from Knoxville

Enter your travel dates to find the best prices.

2:49 pm - 4:31 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 42mnonstop

6:51 pm - 8:39 pmMCO Orlando-TYS Knoxville McGhee Tyson

1h 48mnonstop

$117Allegiant Air

Mon, Aug 31 - Mon, Sep 14

10:54 am - 12:59 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$135Allegiant Air

Thu, Sep 3 - Sun, Sep 6

2:49 pm - 4:31 pmTYS Knoxville McGhee Tyson-MCO Orlando

1h 42mnonstop

9:05 am - 7:34 pmMCO Orlando-TYS Knoxville McGhee Tyson

10h 29m1 stop Philadelphia

$195Multiple Airlines

Mon, Aug 31 - Mon, Sep 14

12:52 pm - 11:53 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

11h 01m1 stop Jacksonville

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$204Multiple Airlines

Thu, Sep 3 - Sun, Sep 6

1:16 pm - 2:18 pmTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

2h 02mnonstop

7:29 pm - 10:17 pmORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 48mnonstop

$349American Airlines

Thu, Sep 3 - Mon, Sep 7

7:00 am - 7:56 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 56mnonstop

6:59 am - 9:57 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 58mnonstop

$349United Airlines

Fri, Sep 4 - Sun, Sep 6

4:22 pm - 9:04 pmTYS Knoxville McGhee Tyson-MCO Orlando

4h 42m1 stop Charlotte Douglas

5:31 pm - 9:50 pmMCO Orlando-TYS Knoxville McGhee Tyson

4h 19m1 stop Charlotte Douglas

$351American Airlines

Tue, Sep 1 - Sat, Sep 5

4:38 pm - 8:08 pmTYS Knoxville McGhee Tyson-IAH Houston George Bush Intcntl

4h 30m1 stop Atlanta Hartsfield-Jackson

2:44 pm - 10:27 pmIAH Houston George Bush Intcntl-TYS Knoxville McGhee Tyson

6h 43m1 stop Atlanta Hartsfield-Jackson

$357Delta

Tue, Sep 1 - Tue, Sep 8

7:30 am - 12:16 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

5h 46m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:44 amHOU Houston Hobby-TYS Knoxville McGhee Tyson

3h 44m1 stop Atlanta Hartsfield-Jackson

$357Delta

Thu, Sep 3 - Fri, Sep 11

7:00 am - 7:56 amTYS Knoxville McGhee Tyson-ORD Chicago O'Hare Intl

1h 56mnonstop

6:59 am - 9:57 amORD Chicago O'Hare Intl-TYS Knoxville McGhee Tyson

1h 58mnonstop

$369United Airlines

Fri, Sep 4 - Sun, Sep 6

Cheapest international flights from Knoxville

Enter your travel dates to find the best prices.

3:54 pm - 11:54 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

8h 00m1 stop Philadelphia

8:45 am - 10:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

25h 20m1 stop Fort Lauderdale

$256Multiple Airlines

Fri, Oct 16 - Tue, Oct 20

1:31 pm - 11:13 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

9h 42m1 stop Orlando Sanford Intl

7:00 am - 8:39 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

13h 39m1 stop Orlando

$259Multiple Airlines

Thu, Sep 17 - Mon, Sep 21

1:54 pm - 10:13 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

20h 19m1 stop Philadelphia

7:15 am - 8:35 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

25h 20m1 stop Fort Lauderdale

$261Multiple Airlines

Fri, Sep 25 - Fri, Oct 2

3:08 pm - 12:08 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

9h 00m1 stop Jacksonville

12:59 am - 9:21 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

20h 22m1 stop Philadelphia

$268Multiple Airlines

Thu, Oct 15 - Sun, Oct 18

12:57 pm - 4:16 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

27h 19m1 stop Philadelphia

8:45 am - 10:05 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

26h 20m1 stop Fort Lauderdale

$273Multiple Airlines

Fri, Oct 30 - Tue, Nov 3

12:57 pm - 10:19 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

21h 22m1 stop Philadelphia

10:09 am - 11:14 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

25h 05m1 stop Orlando

$284Multiple Airlines

Fri, Oct 23 - Sun, Oct 25

3:54 pm - 11:54 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

8h 00m1 stop Philadelphia

5:11 pm - 5:33 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

48h 22m2 stops Atlanta Hartsfield-Jackson Jacksonville

$285Multiple Airlines

Fri, Oct 16 - Tue, Oct 20

10:28 am - 1:52 amTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

15h 24m1 stop Orlando

8:45 am - 5:14 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

8h 29m1 stop Fort Lauderdale

$289Multiple Airlines

Wed, Sep 30 - Tue, Oct 6

4:14 pm - 1:31 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

21h 17m1 stop Fort Lauderdale

7:23 am - 1:31 pmSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

7h 08m1 stop Orlando

$307Multiple Airlines

Wed, Oct 14 - Mon, Nov 9

5:40 pm - 3:17 pmTYS Knoxville McGhee Tyson-SJU San Juan Luis Munoz Marin Intl

21h 37m1 stop Fort Lauderdale

7:00 am - 10:14 amSJU San Juan Luis Munoz Marin Intl-TYS Knoxville McGhee Tyson

27h 14m1 stop Fort Lauderdale

$308Multiple Airlines

Mon, Sep 14 - Fri, Sep 18

Cheapest domestic flights from Knoxville

Enter your travel dates to find the best prices.

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

8:00 am - 10:05 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$75Allegiant Air

Fri, Oct 23 - Sat, Oct 31

9:28 pm - 11:29 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

8:00 am - 10:05 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$85Allegiant Air

Fri, Oct 23 - Sat, Oct 31

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

8:00 am - 10:04 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 04mnonstop

$93Allegiant Air

Sat, Sep 19 - Wed, Sep 23

12:57 pm - 2:14 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 17mnonstop

5:04 pm - 8:08 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 04mnonstop

$97Allegiant Air

Fri, Oct 2 - Mon, Oct 19

9:36 pm - 11:37 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

5:19 pm - 7:24 pmFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$99Allegiant Air

Sat, Oct 10 - Mon, Oct 26

12:54 pm - 2:11 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 17mnonstop

5:04 pm - 8:08 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 04mnonstop

$99Allegiant Air

Fri, Oct 9 - Mon, Oct 19

9:05 am - 11:06 amTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 01mnonstop

6:20 am - 8:25 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$105Allegiant Air

Thu, Oct 22 - Sun, Oct 25

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

6:30 am - 8:35 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$106Allegiant Air

Sat, Sep 26 - Sat, Oct 3

6:55 pm - 9:00 pmTYS Knoxville McGhee Tyson-FLL Fort Lauderdale

2h 05mnonstop

6:30 am - 8:35 amFLL Fort Lauderdale-TYS Knoxville McGhee Tyson

2h 05mnonstop

$107Allegiant Air

Sat, Sep 26 - Sat, Oct 3

12:54 pm - 2:11 pmTYS Knoxville McGhee Tyson-HOU Houston Hobby

2h 17mnonstop

5:04 pm - 8:08 pmHOU Houston Hobby-TYS Knoxville McGhee Tyson

2h 04mnonstop

$110Allegiant Air

Fri, Oct 9 - Mon, Oct 19

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

From Knoxville McGhee Tyson, you can take domestic flights to many cities. Searches reveal that momondo users prefer flights to Jacksonville, Chicago, Phoenix, Key West, and New York the most.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Sarasota at $33. The next cheapest destinations are Jacksonville, Orlando, Tampa, Austin and Houston.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by Delta, Allegiant Air, and American Airlines. For example, Delta flights from Knoxville to Memphis, start at $41, Allegiant Air flights from Knoxville to Washington, D.C. Dulles Intl Airport cost around $46, and American Airlines flights from Knoxville to Washington, D.C. are around $50.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $33 to Sarasota. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $70 to travel from Knoxville to Sarasota.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago O'Hare Intl Airport and Chicago are currently the destinations served most frequently from Knoxville, with 25, 20 and 20 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, United Airlines and Delta frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $437.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of August 2026, there are 25 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.