Cheap flights from Knoxville (TYS) from $82

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Fly to

Route

Depart

Return

Price

KnoxvilleDenver

TYS - DEN

TYSDEN

Knoxville McGhee Tyson

dom 12/14

4:52 pm-6:23 pm

Nonstop3h 31m

$53

KnoxvilleOrlando

TYS - SFB

TYSSFB

Knoxville McGhee Tyson

dom 12/7

8:30 am-10:05 am

Nonstop1h 35m

$54

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

dom 2/1

1:39 pm-2:07 pm

1 stop25h 28m

$77

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

dom 12/7

5:23 pm-6:45 pm

1 stop25h 22m

$86

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

seg 4/27

6:35 am-1:45 pm

2 stops8h 10m

$140

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

ter 12/30

6:20 pm-11:46 pm

1 stop6h 26m

$144

KnoxvilleHouston

TYS - IAH

TYSIAH

Knoxville McGhee Tyson

seg 12/29

6:20 pm-11:50 pm

1 stop6h 30m

$144

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

seg 4/27

6:45 pm-12:05 am

1 stop6h 20m

$189

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

seg 12/15

5:40 am-9:34 am

1 stop4h 54m

$234

KnoxvilleHouston

TYS - HOU

TYSHOU

Knoxville McGhee Tyson

seg 12/29

6:59 pm-11:11 pm

1 stop5h 12m

$270

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

Where can I directly fly to from Knoxville?

Currently, 13 destinations can be reached directly via flights from Knoxville.

Flights from Knoxville to

Austin

from$57

Flights from Knoxville to

Baltimore

from$257

Flights from Knoxville to

Boston

from$101

Flights from Knoxville to

Denver

from$65

Flights from Knoxville to

Fort Lauderdale

from$74

Flights from Knoxville to

Jacksonville

from$92

Flights from Knoxville to

Key West

from$90

Flights from Knoxville to

Las Vegas

from$97

Flights from Knoxville to

Memphis

from$31

Flights from Knoxville to

Punta Gorda

from$85

Flights from Knoxville to

Sarasota

from$46

Flights from Knoxville to

Tampa

from$48

Flights from Knoxville to

Valparaiso, Florida

from$106

Find the cheapest flights from Knoxville

One-way

Last minute

International

Domestic

Cheap one-way flights from Knoxville

Enter your travel dates to find the best prices.

4:52 pm - 6:23 pmTYS-DEN

3h 31mnonstop

$53Frontier

Find Deal

dom, dez 14

8:30 am - 10:05 amTYS-SFB

1h 35mnonstop

$54Allegiant Air

Find Deal

dom, dez 7

1:39 pm - 2:07 pmTYS-ORD

25h 28m1 stop

$77Multiple Airlines

Find Deal

dom, fev 1

5:23 pm - 6:45 pmTYS-MIA

25h 22m1 stop

$86Multiple Airlines

Find Deal

dom, dez 7

6:35 am - 1:45 pmTYS-HOU

8h 10m2 stops

$140Southwest

Find Deal

seg, abr 27

6:20 pm - 11:46 pmTYS-HOU

6h 26m1 stop

$144American Airlines

Find Deal

ter, dez 30

6:20 pm - 11:50 pmTYS-IAH

6h 30m1 stop

$144American Airlines

Find Deal

seg, dez 29

6:45 pm - 12:05 amTYS-HOU

6h 20m1 stop

$189Southwest

Find Deal

seg, abr 27

5:40 am - 9:34 amTYS-HOU

4h 54m1 stop

$234Delta

Find Deal

seg, dez 15

6:59 pm - 11:11 pmTYS-HOU

5h 12m1 stop

$270Delta

Find Deal

seg, dez 29

Flights from Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Knoxville to help you craft the best travel plan.

Prices

Other information

What are the most popular domestic flights out of Knoxville McGhee Tyson?

According to searches, the most popular destinations for domestic flights from Knoxville McGhee Tyson among momondo users are Chicago, Key West, Jacksonville, Phoenix and New York.

What are the cheapest cities to fly to from Knoxville?

The cheapest city to fly to from Knoxville currently is Memphis at $31. The next cheapest destinations are Washington, D.C., Sarasota, Houston, Tampa and Chicago.

Frequently asked questions regarding flights from Knoxville

Which airlines are currently offering the cheapest flights from Knoxville?

Our data suggests that currently, the cheapest flights from Knoxville are being offered by American Airlines, Delta, and Allegiant Air. For example, American Airlines flights from Knoxville to South Bend, start at $31, Delta flights from Knoxville to Washington, D.C. Dulles Intl Airport cost around $43, and Allegiant Air flights from Knoxville to Gulf Shores are around $72.

What is the cheapest flight available from Knoxville?

Currently, the cheapest flight from Knoxville found by our users is for $31 to Memphis. Prices will vary according to several factors such as the departure date and time, but on average you can expect to pay around $96 to travel from Knoxville to Memphis.

Which destinations have the most frequent flights from Knoxville?

Atlanta, Chicago and Chicago O'Hare Intl Airport are currently the destinations served most frequently from Knoxville, with 31, 30 and 30 flights per day on average, respectively.

Which airlines can you fly with from Knoxville?

Airlines including American Airlines, Delta and United Airlines frequently fly from Knoxville. You can view other airlines by performing a quick search in the form above.

What is the cheapest first class flight from Knoxville?

If you are looking for a cheap first class flight, consider flights to Chicago O'Hare Intl Airport, for which the starting price of a first class seat can be as low as $379.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport?

Prices for flights from Knoxville McGhee Tyson Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport?

As of November 2025, there are 24 operators available to choose from for flights from Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.