Cheap flights from the United States to South America from $105

In general, September is the cheapest month to fly from United States to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $556. If you aren’t able to travel during the month of September, then book flights to South America from United States during October instead. Flights to South America in October, while not as cheap as those in September, still average around $564.

The cheapest day to depart from United States to South America is on a Monday when prices can be found for as low as $889. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from United States to South America for around $1,002.

Our data shows that the cheapest United States to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $914. If you have a flexible travel schedule, then try to avoid flying in the evening when prices are $976 on average. Flights to South America from United States in the evening are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Miami to Medellín Jose Maria Cordova Intl for the best United States - South America flight prices

You are more likely to see cheaper flights to South America from United States when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $685 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from United States for as low as $616 on momondo.

There are 4 cabin classes available to choose from on United States to South America flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Copa Airlines, United Airlines, and Delta are the most popular carriers operating from United States to South America

Avianca, LATAM Airlines and Copa Airlines are the top three most popular airlines that fly to South America from United States according to our data. Avianca is the first choice among our users, with 29% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 20 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

The number of flights available between United States and South America is 86 per day as of July 2026. The most frequent departure time is 5:00PM, with 39% of daily flights leaving in the evening.

608 flights are operational weekly from United States to South America as of July 2026. The most popular departure day for this route is Wed, with 17% of flights per week taking off on this day.