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Cheap flights from Tampa to Knoxville from $80

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Tampa to Knoxville departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:45 am - 3:33 pm
TPA
-
TYS
8h 48m
1 stop
Frontier Logo
8:08 pm - 5:37 am
TYS
-
TPA
9h 29m
1 stop
$195Frontier
Sun, May 17 - Fri, May 22
Multiple Airlines Logo
6:46 pm - 10:36 am
TPA
-
TYS
15h 50m
1 stop
Multiple Airlines Logo
2:56 pm - 9:59 pm
TYS
-
TPA
7h 03m
1 stop
$197Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
Multiple Airlines Logo
8:00 am - 1:16 pm
TPA
-
TYS
5h 16m
1 stop
Multiple Airlines Logo
3:00 pm - 7:19 am
TYS
-
TPA
16h 19m
1 stop
$206Multiple Airlines
Mon, Mar 30 - Tue, Mar 31
Multiple Airlines Logo
10:54 pm - 11:39 pm
TPA
-
TYS
24h 45m
1 stop
Multiple Airlines Logo
4:25 pm - 9:59 pm
TYS
-
TPA
5h 34m
1 stop
$208Multiple Airlines
Wed, Apr 1 - Wed, Apr 8
Multiple Airlines Logo
10:54 pm - 12:45 pm
TPA
-
TYS
13h 51m
2 stops
Multiple Airlines Logo
2:56 pm - 9:59 pm
TYS
-
TPA
7h 03m
1 stop
$211Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
Multiple Airlines Logo
6:46 pm - 12:45 pm
TPA
-
TYS
17h 59m
2 stops
Multiple Airlines Logo
2:56 pm - 9:59 pm
TYS
-
TPA
7h 03m
1 stop
$217Multiple Airlines
Tue, Mar 31 - Tue, Apr 7
Multiple Airlines Logo
10:54 pm - 10:26 pm
TPA
-
TYS
23h 32m
1 stop
Multiple Airlines Logo
3:00 pm - 9:59 pm
TYS
-
TPA
6h 59m
1 stop
$219Multiple Airlines
Wed, Mar 25 - Tue, Mar 31
Multiple Airlines Logo
10:54 pm - 11:39 pm
TPA
-
TYS
24h 45m
1 stop
Multiple Airlines Logo
9:00 am - 5:41 pm
TYS
-
TPA
8h 41m
1 stop
$223Multiple Airlines
Wed, Apr 1 - Mon, Apr 6
Multiple Airlines Logo
8:00 am - 1:16 pm
TPA
-
TYS
5h 16m
1 stop
Multiple Airlines Logo
3:00 pm - 12:26 am
TYS
-
TPA
9h 26m
2 stops
$234Multiple Airlines
Mon, Mar 30 - Tue, Mar 31
Frontier Logo
6:00 am - 3:28 pm
TPA
-
TYS
9h 28m
1 stop
Frontier Logo
4:20 pm - 5:50 am
TYS
-
TPA
13h 30m
1 stop
$235Frontier
Fri, Apr 3 - Fri, Apr 10

Southwest flights from Tampa to Knoxville

Our best Southwest deals on Tampa to Knoxville flight tickets
Southwest
Mar 31
TPA10:05 amTampa
10h 00m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
Apr 7
TYS7:05 amKnoxville McGhee Tyson
9h 45m
2 stops
TPA4:50 pmTampa
$278
Southwest
Apr 29
TPA7:25 amTampa
6h 55m
1 stop
TYS2:20 pmKnoxville McGhee Tyson
May 1
TYS8:05 amKnoxville McGhee Tyson
7h 30m
1 stop
TPA3:35 pmTampa
$283
Southwest
Mar 30
TPA2:00 pmTampa
8h 10m
2 stops
TYS10:10 pmKnoxville McGhee Tyson
Mar 31
TYS6:35 amKnoxville McGhee Tyson
7h 45m
2 stops
TPA2:20 pmTampa
$285

American Airlines flights from Tampa to Knoxville

Our best American Airlines deals on Tampa to Knoxville flight tickets
American Airlines
Mar 31
TPA5:33 pmTampa
6h 26m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 7
TYS5:00 amKnoxville McGhee Tyson
5h 09m
1 stop
TPA10:09 amTampa
$267
American Airlines
Mar 31
TPA6:35 pmTampa
4h 13m
1 stop
TYS10:48 pmKnoxville McGhee Tyson
Apr 7
TYS5:00 amKnoxville McGhee Tyson
5h 09m
1 stop
TPA10:09 amTampa
$291
American Airlines
May 6
TPA7:45 pmTampa
4h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 10
TYS5:00 amKnoxville McGhee Tyson
5h 49m
1 stop
TPA10:49 amTampa
$293

momondo Fare Finder

 
Customize your flight search to find flights from Tampa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Tampa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Sun 5/17

6:45 am-3:33 pm

1 stop8h 48m

Knoxville McGhee Tyson

Fri 5/22

8:08 pm-5:37 am

1 stop9h 29m

$195

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Tue 3/31

6:46 pm-10:36 am

1 stop15h 50m

Knoxville McGhee Tyson

Tue 4/7

2:56 pm-9:59 pm

1 stop7h 03m

$197

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Mon 3/30

8:00 am-1:16 pm

1 stop5h 16m

Knoxville McGhee Tyson

Tue 3/31

3:00 pm-7:19 am

1 stop16h 19m

$206

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Wed 4/1

10:54 pm-11:39 pm

1 stop24h 45m

Knoxville McGhee Tyson

Wed 4/8

4:25 pm-9:59 pm

1 stop5h 34m

$208

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Tue 3/31

10:54 pm-12:45 pm

2 stops13h 51m

Knoxville McGhee Tyson

Tue 4/7

2:56 pm-9:59 pm

1 stop7h 03m

$211

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Tue 3/31

6:46 pm-12:45 pm

2 stops17h 59m

Knoxville McGhee Tyson

Tue 4/7

2:56 pm-9:59 pm

1 stop7h 03m

$217

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Wed 3/25

10:54 pm-10:26 pm

1 stop23h 32m

Knoxville McGhee Tyson

Tue 3/31

3:00 pm-9:59 pm

1 stop6h 59m

$219

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Wed 4/1

10:54 pm-11:39 pm

1 stop24h 45m

Knoxville McGhee Tyson

Mon 4/6

9:00 am-5:41 pm

1 stop8h 41m

$223
Quickest round-trip

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Mon 3/30

8:00 am-1:16 pm

1 stop5h 16m

Knoxville McGhee Tyson

Tue 3/31

3:00 pm-12:26 am

2 stops9h 26m

$234

TampaKnoxville

TPA - TYS

TPATYS

Tampa

Fri 4/3

6:00 am-3:28 pm

1 stop9h 28m

Knoxville McGhee Tyson

Fri 4/10

4:20 pm-5:50 am

1 stop13h 30m

$235

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Tampa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Tampa, with most prices found around $267. If you aren’t able to travel during the month of January, then book flights to Knoxville from Tampa during September instead. Flights to Knoxville in September, while not as cheap as those in January, still average around $287.

What is the cheapest Tampa to Knoxville McGhee Tyson flight route?

Fly from Tampa to Knoxville McGhee Tyson for the best Tampa - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Tampa when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $316 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Tampa for as low as $152 on momondo.

What cabin class options are available on Tampa to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Tampa to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Tampa to Knoxville flights?

You could potentially save up to 14% on your flight if you consider stops on a Tampa to Knoxville flight.

How have Tampa to Knoxville flight prices changed over time?

As of March 2026, prices for Tampa to Knoxville flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from Tampa to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Tampa to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Tampa to Knoxville (TPA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Tampa to Knoxville

Fastest flight time

3h 41m

Direct flights

Sun

Airports in Knoxville

1 airport
The fastest flight from Tampa to Knoxville takes 3h 41m
Direct flights go from Tampa to Knoxville on Sunday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From Tampa there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Tampa to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 559.5 mi away from Tampa. By plane, this route typically takes 3h 41m.

  • When did momondo last update prices for flights from Tampa Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Tampa Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Tampa Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Tampa Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Tampa Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Tampa to Knoxville?

  • What is the most popular airline from Tampa to Knoxville?

Best airlines flying from Tampa to Knoxville

Compare and see reviews for airlines that fly from Tampa to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $85Free CancellationRating
7.3
714 reviews
Search Allegiant Air flights
DeltaPriceFrom $198Free CancellationRating
7.9
8,269 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,398 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Tampa to Knoxville?

Finding the right flight to Knoxville from Tampa is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Tampa to Knoxville with flexible booking policies on momondo?

All flight searches from Tampa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Tampa to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Tampa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Tampa to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Tampa to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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