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Cheap flights from Syracuse to St. Louis from $242

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Syracuse to St. Louis departing on 6/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Syracuse to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:21 am - 11:57 pm
SYR
-
STL
14h 36m
1 stop
Multiple Airlines Logo
4:19 pm - 6:35 pm
STL
-
SYR
25h 16m
1 stop
$283Multiple Airlines
Fri, May 29 - Thu, Jun 4
Multiple Airlines Logo
12:22 pm - 8:55 am
SYR
-
STL
21h 33m
2 stops
Multiple Airlines Logo
4:19 pm - 6:35 pm
STL
-
SYR
25h 16m
1 stop
$284Multiple Airlines
Fri, May 29 - Thu, Jun 4
American Airlines Logo
7:30 pm - 11:59 pm
SYR
-
STL
5h 29m
1 stop
American Airlines Logo
5:00 pm - 11:57 pm
STL
-
SYR
5h 57m
1 stop
$291American Airlines
Thu, May 28 - Tue, Jun 2
Multiple Airlines Logo
7:26 pm - 8:55 am
SYR
-
STL
38h 29m
2 stops
Multiple Airlines Logo
4:19 pm - 6:35 pm
STL
-
SYR
25h 16m
1 stop
$294Multiple Airlines
Thu, May 28 - Thu, Jun 4
Delta Logo
6:12 am - 9:31 am
SYR
-
STL
4h 19m
1 stop
Delta Logo
3:57 pm - 11:13 pm
STL
-
SYR
6h 16m
1 stop
$300Delta
Wed, Jul 8 - Mon, Jul 13
Delta Logo
6:00 am - 9:49 am
SYR
-
STL
4h 49m
1 stop
Delta Logo
5:36 pm - 11:00 pm
STL
-
SYR
4h 24m
1 stop
$304Delta
Sun, May 24 - Sat, May 30
Delta Logo
6:54 pm - 11:56 pm
SYR
-
STL
6h 02m
1 stop
Delta Logo
5:22 pm - 11:09 pm
STL
-
SYR
4h 47m
1 stop
$309Delta
Mon, Jun 8 - Mon, Jun 15
Delta Logo
12:59 pm - 5:56 pm
SYR
-
STL
5h 57m
1 stop
Delta Logo
9:21 am - 5:59 pm
STL
-
SYR
7h 38m
1 stop
$317Delta
Thu, Jun 4 - Mon, Jun 8
American Airlines Logo
7:26 pm - 11:56 pm
SYR
-
STL
5h 30m
1 stop
American Airlines Logo
5:51 am - 11:00 am
STL
-
SYR
4h 09m
1 stop
$339American Airlines
Fri, May 15 - Tue, May 19
Delta Logo
7:03 pm - 11:59 pm
SYR
-
STL
5h 56m
1 stop
Delta Logo
5:36 pm - 11:43 pm
STL
-
SYR
5h 07m
1 stop
$344Delta
Thu, Jun 4 - Mon, Jun 8

American Airlines flights from Syracuse to St. Louis

Our best American Airlines deals on Syracuse to St. Louis flight tickets
American Airlines
May 28
SYR7:30 pmSyracuse Hancock Intl
5h 29m
1 stop
STL11:59 pmLambert-St Louis
Jun 2
STL5:00 pmLambert-St Louis
5h 57m
1 stop
SYR11:57 pmSyracuse Hancock Intl
$291
American Airlines
May 12
SYR6:00 amSyracuse Hancock Intl
4h 25m
1 stop
STL9:25 amLambert-St Louis
May 19
STL7:00 amLambert-St Louis
6h 04m
1 stop
SYR2:04 pmSyracuse Hancock Intl
$324
American Airlines
May 15
SYR7:26 pmSyracuse Hancock Intl
5h 30m
1 stop
STL11:56 pmLambert-St Louis
May 19
STL5:51 amLambert-St Louis
4h 09m
1 stop
SYR11:00 amSyracuse Hancock Intl
$339

Delta flights from Syracuse to St. Louis

Our best Delta deals on Syracuse to St. Louis flight tickets
Delta
Jul 8
SYR6:12 amSyracuse Hancock Intl
4h 19m
1 stop
STL9:31 amLambert-St Louis
Jul 13
STL3:57 pmLambert-St Louis
6h 16m
1 stop
SYR11:13 pmSyracuse Hancock Intl
$300
Delta
May 24
SYR6:00 amSyracuse Hancock Intl
4h 49m
1 stop
STL9:49 amLambert-St Louis
May 30
STL5:36 pmLambert-St Louis
4h 24m
1 stop
SYR11:00 pmSyracuse Hancock Intl
$304
Delta
Jun 8
SYR6:54 pmSyracuse Hancock Intl
6h 02m
1 stop
STL11:56 pmLambert-St Louis
Jun 15
STL5:22 pmLambert-St Louis
4h 47m
1 stop
SYR11:09 pmSyracuse Hancock Intl
$309

momondo Fare Finder

 
Customize your flight search to find flights from Syracuse to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 3, 2026.
Use the filters below to find and compare flights from Syracuse to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 5/29

10:21 am-11:57 pm

1 stop14h 36m

Lambert-St Louis

Thu 6/4

4:19 pm-6:35 pm

1 stop25h 16m

$283

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 5/29

12:22 pm-8:55 am

2 stops21h 33m

Lambert-St Louis

Thu 6/4

4:19 pm-6:35 pm

1 stop25h 16m

$284

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 5/28

7:30 pm-11:59 pm

1 stop5h 29m

Lambert-St Louis

Tue 6/2

5:00 pm-11:57 pm

1 stop5h 57m

$291

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 5/28

7:26 pm-8:55 am

2 stops38h 29m

Lambert-St Louis

Thu 6/4

4:19 pm-6:35 pm

1 stop25h 16m

$294

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Wed 7/8

6:12 am-9:31 am

1 stop4h 19m

Lambert-St Louis

Mon 7/13

3:57 pm-11:13 pm

1 stop6h 16m

$300
Quickest round-trip

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Sun 5/24

6:00 am-9:49 am

1 stop4h 49m

Lambert-St Louis

Sat 5/30

5:36 pm-11:00 pm

1 stop4h 24m

$304

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Mon 6/8

6:54 pm-11:56 pm

1 stop6h 02m

Lambert-St Louis

Mon 6/15

5:22 pm-11:09 pm

1 stop4h 47m

$309

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 6/4

12:59 pm-5:56 pm

1 stop5h 57m

Lambert-St Louis

Mon 6/8

9:21 am-5:59 pm

1 stop7h 38m

$317

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Fri 5/15

7:26 pm-11:56 pm

1 stop5h 30m

Lambert-St Louis

Tue 5/19

5:51 am-11:00 am

1 stop4h 09m

$339

SyracuseSt. Louis

SYR - STL

SYRSTL

Syracuse Hancock Intl

Thu 6/4

7:03 pm-11:59 pm

1 stop5h 56m

Lambert-St Louis

Mon 6/8

5:36 pm-11:43 pm

1 stop5h 07m

$344

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Syracuse to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Syracuse and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, January is the cheapest month to fly from Syracuse to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $283. The month of February is another great option to travel to St. Louis, with average flight prices from Syracuse averaging around $309.

How far in advance should I book a flight from Syracuse to St. Louis?

You are more likely to see cheaper flights to St. Louis from Syracuse when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $352 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Syracuse for as low as $290 on momondo.

How have Syracuse to St. Louis flight prices changed over time?

When to book flights from Syracuse to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Syracuse to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Syracuse to St. Louis (SYR to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Syracuse to St. Louis

Fastest flight time

4h 21m

Direct flights

None
The fastest flight from Syracuse to St. Louis takes 4h 21m
There are no direct flights from Syracuse to St. Louis. There are no popular flight routes from Syracuse to St. Louis.
Search flight deals

Frequently asked questions about flying from Syracuse to St. Louis

  • How far is Syracuse Hancock Intl to Lambert-St Louis by plane?

    The distance between Syracuse Hancock Intl and Lambert-St Louis is about 793.6 mi. By plane, this route typically takes 4h 21m.

  • When did momondo last update prices for flights from Syracuse Hancock Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Syracuse Hancock Intl Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Syracuse Hancock Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Syracuse Hancock Intl Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Syracuse Hancock Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Syracuse to St. Louis?

Best airlines flying from Syracuse to St. Louis

Compare and see reviews for airlines that fly from Syracuse to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $218Free CancellationRating
7.4
9,681 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,672 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,460 reviews
Search Delta flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Wentzville
Alton
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Syracuse to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Syracuse to St. Louis for you.

Can I find flights from Syracuse to St. Louis with flexible booking policies on momondo?

Flights from Syracuse to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Syracuse to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Syracuse.

I’m not ready to book a flight from Syracuse to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Syracuse. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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